| increased density of helicobacter pylori on antral biopsy is associated with severity of acute and chronic inflammation and likelihood of duodenal ulceration. | an increased risk of ulcers and severity of inflammation with increased degree of helicobacter pylori (hp) infection (biological gradient) would support the hypothesis that hp causes ulcers. a blinded pathologist evaluated antral biopsies obtained at endoscopy in 903 patients. the level of hp infection was assessed on warthin starry stain, and the severity of acute and chronic inflammation on hematoxylin and eosin graded from 0 to 3. the presence of duodenal ulcers was associated with increasing ... | 1992 | 1553928 |
| serum pepsinogen i levels of gastric ulcer patients are determined by the location of the ulcer crater. | to examine the relation between gastric ulcer (gu) location and serum pepsinogen i (pgi) level, we measured this marker in 284 endoscopically proved gu patients. their ulcer locations were further divided according to johnson's criteria modified to the corpus (type 1a), gastric angle (type 1b), combined with duodenal ulcer (type 2) and prepyloric area (type 3). the number of each subset were 96, 81, 58 and 49, respectively. mean serum pgi level (99.6 +/- 44.8 ng/ml) of all gu patients showed no ... | 1992 | 1555752 |
| production of a conserved adhesin by the human gastroduodenal pathogen helicobacter pylori. | an adhesin protein with an approximate subunit molecular weight of 19,600 has been purified from the gastric pathogen helicobacter pylori. the protein was loosely associated with the cell surface and was removed by gentle stirring or shearing. released aggregates of the 19.6-kda protein were removed from suspension by ultracentrifugation and separated from contaminating membranes by washing in 1.0% sodium dodecyl sulfate (sds). the sds-insoluble protein was purified further by mono q anion-excha ... | 1992 | 1556073 |
| helicobacter pylori associated phospholipase a2 activity: a factor in peptic ulcer production? | to examine the potential role of the lipolytic enzyme phospholipase a2, produced by helicobacter pylori in ulcer formation. | 1992 | 1556229 |
| secretion of intravenously administered antibiotics in gastric juice: implications for management of helicobacter pylori. | to study whether differences in eradication rates of antibiotics may be explained by differences in secretion of antibiotics in gastric juice. | 1992 | 1556230 |
| effect of physical environment on survival of helicobacter pylori. | to determine the effects of physical conditions on survival of helicobacter pylori in aquatic environments. survival for prolonged time intervals would implicate environmental water as a possible source of infection. | 1992 | 1556231 |
| helicobacter pylori infection and duodenal ulcer disease. | | 1992 | 1556517 |
| effect of treatment of helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. a randomized, controlled study. | to determine the effect of treating helicobacter pylori infection on the recurrence of gastric and duodenal ulcer disease. | 1992 | 1558340 |
| helicobacter pylori: selection of patients for treatment. | | 1992 | 1558351 |
| current trends in the pharmacotherapy for peptic ulcer disease. | a variety of options are available for the medical treatment of peptic ulcer disease, including antacids, histamine2 receptor antagonists, omeprazole, prostaglandin analogues, and sucralfate and bismuth formulations. seventy percent to 90% of peptic duodenal and gastric ulcers will heal after 4 to 8 weeks of therapy. combination regimens using these agents have not been demonstrated to be superior to single-agent therapy. aggressive acid suppression with "high-dose" histamine2 receptor antagonis ... | 1992 | 1558429 |
| endoscopy in peptic ulcer disease: diagnosis, prognosis and management. | | 1992 | 1559493 |
| igg subclass response to helicobacter pylori in patients with chronic active gastritis and duodenal ulcer. | the igg subclass response is determined by the type of bacteria producing the infection and by genetic factors of the host. patients with a helicobacter pylori infection develop a specific immune response that is mainly of the iga and igg class. we measured the igg subclass response in 20 patients with chronic active gastritis without a history of duodenal ulcer and 20 patients with chronic active gastritis and duodenal ulcer diagnosed by endoscopy and histology. a control group included 20 h. p ... | 1992 | 1561526 |
| helicobacter pylori and duodenal ulcer. evidence suggesting causation. | | 1992 | 1563322 |
| helicobacter pylori infection in patients with upper gastrointestinal symptoms in arba minch hospital: southwestern ethiopia. | a prospective study was conducted to determine the frequency of occurrence of helicobacter pylori infection in outpatients presenting with upper gastro intestinal symptoms to arba minch hospital over a one year period. four hundred and forty four patient, 309 males and 135 females, underwent upper gastro intestinal fiberoptic endoscopy between march 1989 and april 1990. the age range was 14 to 75 years (mean = 35). all 444 patients were examined and tested for infection. sixty per cent had abnor ... | 1992 | 1563364 |
| elevated risk of helicobacter pylori infection in submarine crews. | in a prospective study designed to elucidate the route of transmission of helicobacter pylori, the seroprevalence and incidence of helicobacter pylori infection was determined in the following branches of the armed forces presumed to be at increased risk of acquiring transmissible diseases by the fecal-oral or oral-oral route: german submarine crews (n = 64, mean age 26.2 years) and regular officers of the french infantry (n = 51, mean age 26.5 years) who had served for a minimum of three years. ... | 1992 | 1563394 |
| [gastropathies with nodules and enlarged folds]. | | 1992 | 1563607 |
| further evidence of the toxic effect of ammonia produced by helicobacter pylori urease on human epithelial cells. | former studies have shown that helicobacter pylori can induce vacuolation of vacuolation of epithelial cells in vitro and possibly in vivo, either by direct action of a cytotoxin or by the action of its strong urease, which breaks down the urea physiologically present in the stomach into cytotoxic ammonia. we have developed a test using hep2 cells with adherent h. pylori bacteria in order to compare the effects of an h. pylori urease-negative variant with those of its urease-positive parent stra ... | 1992 | 1563774 |
| characterization of helicobacter pylori urease mutants. | the association between helicobacter pylori, gastritis, and peptic ulcer is well established, and the association of infection with gastric cancer has been noted in several developing countries. however, the pathogenic mechanism(s) leading to disease states has not been elucidated. the h. pylori urease is thought to be a determinant of pathogenicity, since the enzyme is produced by all h. pylori clinical isolates. evidence indicates that some h. pylori strains are more cytotoxic than others, wit ... | 1992 | 1563778 |
| identification and purification of a cpn60 heat shock protein homolog from helicobacter pylori. | helicobacter pylori is associated with gastritis and peptic ulcer disease in humans. we have identified a homolog of the chaperonin cpn60 family of heat shock proteins in h. pylori, referred to as hp54k. hp54k, purified from water-extractable h. pylori proteins, migrated as a single band at 54 kda by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. its native molecular mass was 740 kda; thus, hp54k apparently comprises a 14-mer. the n-terminal 33 residues of hp54k exhibited 60.6, 57.6, ... | 1992 | 1563786 |
| ultrastructural study of helicobacter pylori adherence properties in gnotobiotic piglets. | ultrastructural examination of gastric mucosa from helicobacter pylori-infected gnotobiotic piglets identified four general adherence patterns comparable to those observed in human patients. intimate associations between the bacterial and mucosal cell membranes, including cuplike invaginations and adherence pedestals, were present and were accompanied by alterations to microvilli and cell membrane morphology. | 1992 | 1563801 |
| adherence and internalization of helicobacter pylori by hep-2 cells. | helicobacter pylori colonizes the mucous layer of the stomach and the surface of gastric mucous cells. although h. pylori is not generally thought of as invasive, it has been observed in the lamina propria and within vacuoles in the cytoplasm of epithelial cells. the authors report that isolates of h. pylori can enter into the cytoplasm of tissue culture epithelial cell lines such as hep-2 cells. intracellular uptake of h. pylori by hep-2 cells is rapid and appears to require both the n-acetylne ... | 1992 | 1568565 |
| difference in expression of helicobacter pylori gastritis in antrum and body. | seven hundred seventy biopsy specimens obtained from 10 different sites in stomachs of 77 patients were examined for the presence of active chronic gastritis (acg) and helicobacter pylori to investigate the characteristics of gastritis in the antrum and body. forty-eight patients with acg at one or more sites were all h. pylori positive. h. pylori was not found in 20 patients who had chronic gastritis with no activity or in 9 patients who had histologically normal mucosa. in patients with acg in ... | 1992 | 1568567 |
| helicobacter pylori and peptic ulcers: the present position. | | 1992 | 1568643 |
| [helicobacter pylori-associated hypertrophic gastritis. imitation of ménétrier disease]. | a 42-year-old man developed giant fold gastritis that was associated with massive helicobacter pylori colonization, highly active, high-grade gastritis and severe hypoproteinemia with gastric protein-loss syndrome. histology revealed marked focal foveolar hyperplasia of the body and fundic mucosa. combination treatment with amoxicillin and omeprazole resulted in the eradication of the helicobacter pylori. concomitantly, the foveolar hyperplasia, gastritis and the giant folds regressed completely ... | 1992 | 1568688 |
| pathologic changes of gastric mucosa colonized by helicobacter pylori. | one hundred eighty-nine consecutive gastric biopsies showing colonization by helicobacter pylori (hp) were studied. epigastric pain and bleeding were the clinical presentations in 167 cases (88.4%). major endoscopic findings were gastritis (n = 72, 38.1%) and ulceration (n = 101, 53.4%). duodenal ulcer was associated with 32 (44.4%) and 29 (28.7%) cases of gastritis and gastric ulcer, respectively. histologically, the hp-colonized gastric epithelium showed characteristic degenerative changes tha ... | 1992 | 1568749 |
| drug resistance of helicobacter pylori: memorandum from a meeting at the sixth international workshop on campylobacter, helicobacter, and related organisms. | | 1992 | 1569352 |
| more on pathogenic mechanisms of helicobacter pylori. | | 1992 | 1571456 |
| beta-2-microglobulin and helicobacter pylori infection in uraemic dialysed patients. | chronic gastritis in patients with chronic renal failure may have different causes and mechanisms. recent observations suggest that severe gastritis often found in uraemic patients might be related to helicobacter pylori (hp) infection. in chronic gastritis hp has been found in the mucus and on the epithelial cell surface of gastric foveolas. significant infiltration of the subepithelial gastric layer by polymorphonuclear leucocytes has been described. moreover, beta-2-microglobulin deposits hav ... | 1992 | 1571503 |
| a comparison of diagnostic tests to determine helicobacter pylori infection. | twenty-five helicobacter pylori positive and 25 h. pylori negative subjects as defined by culture and phase contrast microscopy of antral biopsy specimens obtained from routine upper endoscopy were studied. antral biopsies were examined by rapid urease test, phase contrast microscopy, culture and histology. venous blood was tested for h. pylori specific igg antibodies by an elisa technique. within 7 days of endoscopy the patients also had a [14c]-urea breath test. the sensitivity and specificity ... | 1992 | 1571505 |
| partial characterization of a cell-free hemolytic factor produced by helicobacter pylori. | maximum cell-free hemolytic activity of helicobacter pylori cultured in broth containing 10% horse serum occurred only after the stationary phase of growth was reached, unlike many hemolysins produced by gram-negative bacteria which are active during exponential growth. this characteristic of the h. pylori hemolytic factor suggested that it might also possess protease activity. however, because no evidence of albumin degradation was found, the hemolysis by cell-free concentrates of h. pylori app ... | 1992 | 1575989 |
| helicobacter pylori and gastric ulcer therapy: reflections and uncertainties. | the relationship between helicobacter pylori (hp) and gastric ulcer therapy is examined by analyzing both the data that suggest that eradication of hp renders the gastric mucosa less susceptible to development of gastric ulcer as well as the substantial body of evidence that does not support this contention. the results reported in clinical trials with colloidal bismuth citrate, antimicrobial agents (furazolidone), and combinations of anti-ulcer and antimicrobial agents (h2-antagonist+cefixime, ... | 1992 | 1576367 |
| cholesterol binding of helicobacter pylori. | h. pylori cells grown on cholesterol-free medium adsorb cholesterol from serum, egg yolk, and vdrl reagent. the binding of cholesterol does not influence the hydrophobicity of the cells. the haemagglutinating activity is slightly diminished. the cell-bound haemolytic activity is completely inhibited. the affinity of h. pylori for cholesterol probably acts as factor of chemotaxis and adherence. | 1992 | 1576402 |
| the role of helicobacter pylori in the pathogenesis of acid-peptic disease. | helicobacter pylori (h pylori) is likely the most common cause of chronic active gastritis in humans. also, h pylori has been found in up to 100% of patients with peptic ulcer disease. recent studies have shown that long-term infection by h pylori is associated with an increased risk of developing gastric carcinoma. the mechanism(s), however, by which h pylori causes gastritis or leads to the development of peptic ulcers and gastric cancer is not well understood. the prevalence of h pylori gradu ... | 1992 | 1576460 |
| mechanisms of gastric and duodenal damage and protection. | by binding to the cyclooxygenase enzyme, non-steroidal, anti-inflammatory drugs (nsaids) inhibit synthesis of prostanoids characteristic of the cell under consideration. for the gastric mucosa, the main products are prostaglandin (pg) e2 or pgi2; for platelets the main product is thromboxane. aspirin irreversibly acetylates the cyclooxygenase enzyme. consequently, it has more prolonged effects, particularly in cells like platelets, which are not rapidly turned over. prostaglandin-dependent prote ... | 1992 | 1577394 |
| evaluation of different solid media used for cultivation of helicobacter (campylobacter) pylori. | the ability of nine blood containing media to support the growth of h. pylori was compared. eighteen strains of h. pylori isolated from antral biopsies were cultivated in two dilutions, for colony counts on the media to be tested. columbia base chocolate agar without additives was found to be the best medium for growth of h. pylori. however, all other fresh blood containing media also supported the growth of this organism satisfactorily. | 1992 | 1577515 |
| helicobacter pylori infection and chronic gastritis in gastric cancer. | to investigate the prevalence of helicobacter pylori associated chronic gastritis in patients with gastric cancer. | 1992 | 1577969 |
| urease activity of helicobacter pylori. | | 1992 | 1577984 |
| [relation between helicobacter pylori and intractable gastric ulcer--pas positive intramucosal mucus as an index]. | helicobacter pylori (hp) is considered to be one of the causes of gastric mucosal injury. using biopsy specimens from the gastric mucosa of patients with gastritis or gastric ulcer, the intramucosal mucus was quantified by computer image analysis to evaluate its relationship with hp. in gastric mucosa positive for hp, the mucus content within the gastric mucosa was significantly decreased. ammonia was administered based on its assumed role in decreasing the mucus content of the gastric mucosa, a ... | 1992 | 1578801 |
| [short-term therapy with high dosage omeprazole and amoxicillin for helicobacter pylori eradication. a pilot study]. | in an open study, 50 patients with helicobacter pylori-associated ulcer disease or severe functional dyspepsia were treated over one week with 2 x 40 mg omeprazole in the morning and evening preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. fourty-seven patients (ulcer disease: n = 40, functional dyspepsia: n = 7) completed the study without contravening the protocol. the proportion of helicobacter pylori eradication four weeks after cessation of study medic ... | 1992 | 1579087 |
| [polymorphism in helicobacter pylori--a key function in recurrence of infection?]. | despite the fact that helicobacter (h.) pylori is ubiquitous throughout the world, little is known at present about the source of infection and mode of transmission. person-to-person transmission may be of importance. the fact that helicobacter pylori can revert to a coccoid form stimulated speculation about its role in transmission and as a possible cause of reinfection in duodenal ulcer disease. various antibacterial agents (bismuth subcitrate 32 mg/l bismuth subsalicylate 64 mg/l, amoxicillin ... | 1992 | 1579096 |
| helicobacter pylori and gastroduodenal disease. | helicobacter pylori infection is now recognized as the primary cause of active chronic gastritis in humans. most infected persons remain asymptomatic, but are at increased risk for the development of peptic ulcer disease and possibly gastric cancer. the pathogenesis of this infection is not well understood, but motility and urease activity are virulence factors in an animal model. the eradication of h. pylori infection is associated with resolution of gastritis and a decreased rate of duodenal u ... | 1992 | 1580578 |
| helicobacter pylori and peptic ulcer disease in sri lanka. | the variation in the healing and the relapse rates of peptic ulcer disease has led to the search for other factors in the pathogensis of peptic ulcer disease. helicobacter pylori is believed to be responsible for these different patterns of healing. the results of a study to detect helicobacter pylori in sri lankan patients having duodenal ulcer, gastric ulcer, gastritis and non-ulcer dyspepsia are presented in this paper. the method employed was the urease test which detects the urease enzyme o ... | 1992 | 1581990 |
| helicobacter pylori: the african enigma. | | 1992 | 1582581 |
| influence of age and helicobacter pylori infection on serum pepsinogens in healthy blood transfusion donors. | in a healthy population pepsinogen a and pepsinogen c increase with advancing age. as pepsinogen a and c are raised in chronic superficial gastritis which is caused by h pylori infection, we investigated whether h pylori is responsible for the age related increase of pepsinogen a and c. in h pylori positive blood transfusion donors serum pepsinogen a (mean (sd) 73 (35) micrograms/ml v 52 (19) micrograms/ml, p much less than 0.01) and c (mean (sd) 24 (13) micrograms/ml v 10 (7) micrograms/ml, p m ... | 1992 | 1582585 |
| assay of urease-inhibiting activity in serum from children infected with helicobacter pylori. | in order to provide a basis for obtaining further information concerning the host response to helicobacter pylori urease, four assay methods for detecting urease-inhibiting activity in serum were examined. a quantitative assay, established in a cobas bio centrifugal fast analyzer and based on detection of the consumption of nadh by glutamate dehydrogenase stimulated by ammonia production, was considered most suitable for large-scale serological work. serum samples from 63 children (aged 5 to 16 ... | 1992 | 1583144 |
| new plate medium for growth and detection of urease activity of helicobacter pylori. | a new medium for detection of urease activity and isolation of helicobacter pylori is proposed. this medium, containing columbia agar base, was supplemented with isovitalex, hemin, urea, and phenol red (nonselective medium [nsm]). both bacterial growth and color change were evaluated and compared with growth in the same medium supplemented with cefsulodin, vancomycin, polymyxin b sulfate, and amphotericin b (selective medium [sm]). twenty-five recent clinical isolates and antral biopsy specimens ... | 1992 | 1583148 |
| characterization of a 25,000-dalton helicobacter pylori protein, cross-reacting with a campylobacter jejuni protein. | extract obtained by ultrasonic disruption of helicobacter pylori bacteria contained a protein with subunit molecular mass of 25 kd which bound antibodies in sera from patients with h. pylori-associated disease. the protein was purified by gel permeation and elution from sds-polyacrylamide gel slices, and was used to raise an anti-25-kd protein-specific rabbit serum. using the antiserum in experiments, the results indicated the following: the protein exists as covalently linked dimers (45 kd) of ... | 1992 | 1586485 |
| triple therapy against helicobacter pylori. | | 1992 | 1586557 |
| helicobacter pylori and gastritis. | | 1992 | 1587206 |
| [serological screening for helicobacter pylori. can a blood test make gastroscopy superfluous?]. | | 1992 | 1587222 |
| mechanism of gastric mucosal damage induced by ammonia. | the mechanism for helicobacter pylori-induced gastric mucosal injury remains obscure. h. pylori has high urease activity to produce ammonia from urea in the stomach. in this study, the effects of ammonia on (a) gastric mucosal integrity, (b) gastric mucosal hemodynamics, (c) mucosal cellular viability, (d) mitochondrial respiration, and (e) energy metabolism of gastric mucosal were investigated. ammonia (ph 10.3) at concentrations of greater than 125 mmol/l caused acute macroscopic gastric mucos ... | 1992 | 1587407 |
| long-term nonsteroidal anti-inflammatory drug use and gastroduodenal injury: the role of helicobacter pylori. | to evaluate the association of helicobacter pylori infection with gastroduodenal ulceration and symptoms in rheumatoid arthritis patients chronically ingesting nonsteroidal anti-inflammatory drugs (nsaids), a population-based study was performed. residents of olmsted county, minnesota, and surrounding counties, 40 years of age and over with active rheumatoid arthritis taking therapeutic dose of nsaids daily for 6 months or more were evaluated (n = 50). an endoscopic score from 0 to 5 was assigne ... | 1992 | 1587409 |
| gastric secretion in normal subjects. | | 1992 | 1587448 |
| the glycerolipid receptor for helicobacter pylori (and exoenzyme s) is phosphatidylethanolamine. | we have previously shown that helicobacter pylori specifically binds to a glycerolipid species preferentially found in the antrum of the human stomach. we now show by high-pressure liquid chromatographic analysis that this species is a form of phosphatidylethanolamine and that h. pylori specifically binds to bona fide phosphatidylethanolamine as detected by a thin-layer chromatogram overlay procedure. considerable variation in the binding of h. pylori to phosphatidylethanolamine from different s ... | 1992 | 1587616 |
| purification and characterization of the vacuolating toxin from helicobacter pylori. | a vacuolating toxin was purified to homogeneity from broth culture supernatant of the human gastric bacterium, helicobacter pylori. the procedure for isolating the toxin included ammonium sulfate precipitation, hydrophobic interactive chromatography, size exclusion chromatography, and anion exchange chromatography, which together resulted in a greater than 5000-fold purification of toxin activity. the molecular mass of the purified, denatured toxin was 87,000 +/- 320 daltons, and the native toxi ... | 1992 | 1587837 |
| helicobacter pylori infection: comparison among four different therapeutic regimens. | helicobacter pylori is both virulent and pathogenic, yet it is not clear what is the best way to treat the infection. this study compares the ability of 4 regimens of colloidal bismuth subcitrate (cbs) 120 mg q.i.d. for 4 weeks, combined with one or two antibiotics, to eradicate helicobacter pylori and assesses the outcome of eradication on antral gastritis and on symptoms of non-ulcer dyspepsia in 140 consecutive subjects (44 duodenal ulcers and 96 non ulcer dyspepsia). endoscopy with antral bi ... | 1992 | 1589252 |
| helicobacter pylori eradication with doxycycline-metronidazole-bismuth subcitrate triple therapy. | triple therapy containing tetracycline hcl is currently among the most efficient combination therapies for eradication of helicobacter pylori. substitution of doxycycline for tetracycline hcl offers advantages of less frequent dosing and extrarenal excretion. in this study patients with duodenal ulcer or non-ulcer dyspepsia positive for h. pylori were randomized to either doxycycline or tetracycline hcl triple therapy in conjunction with bismuth subcitrate and metronidazole. of the 34 patients t ... | 1992 | 1589705 |
| oxyntic and antral gastritis in the people's republic of china: diagnosis and relationship to helicobacter pylori. | this study investigates the relationship between gastritis and helicobacter pylori infection in the chinese population. particular focus was placed upon the grading of gastritis, using the recently developed "sydney system." five diagnostic procedures were used to establish h. pylori status, all of which were found to be highly sensitive and specific. histological chronic gastritis was reported in 93/108 (86.1%) of the patients examined, h. pylori infection being present in 73/93 (78.5%), and in ... | 1992 | 1590312 |
| metronidazole resistance among helicobacter pylori strains in malaysia. | | 1992 | 1590330 |
| role of metronidazole resistance in therapy of helicobacter pylori infections. | susceptibility to metronidazole was determined by disk diffusion tests for 559 strains of helicobacter pylori isolated from patients. the overall metronidazole resistance was 26%. in males metronidazole-resistant strains made 18% of all h. pylori strains, and in females the corresponding figure was 40% (p less than 0.001). mics of metronidazole were determined for h. pylori strains from 86 patients undertaking triple therapy, i.e., treatment with colloidal bismuth subcitrate, amoxicillin, and me ... | 1992 | 1590683 |
| bactericidal activity of antimicrobial agents against slowly growing helicobacter pylori. | the doubling times of bacteria at sites of colonization or infection are considerably longer than those in laboratory culture media, and slow growth reduces the susceptibility of bacteria to antimicrobial agents. helicobacter pylori is susceptible to a wide range of antimicrobial agents in vitro; however, tests for inhibitory activity do not adequately predict which antimicrobial agents will eradicate slowly growing h. pylori from the stomachs of patients. the chemostat can be used to compare th ... | 1992 | 1590687 |
| helicobacter pylori lipopolysaccharide effect on the synthesis and secretion of gastric sulfomucin. | the effect of h. pylori lipopolysaccharide on the synthesis and secretion of sulfated mucin in gastric mucosa was investigated using mucosal segments incubated in the presence of [3h]proline, [3h]glucosamine and [35s]na2so4. the lipopolysaccharide, while showing no discernible effect on the apomucin synthesis was found to inhibit the process of mucin glycosylation and sulfation, which at 100 micrograms/ml lipopolysaccharide reached the optimal inhibition of 65%. the analysis of mucin secretory r ... | 1992 | 1590801 |
| electron microscopic evidence of treponema pallidum and helicobacter pylori in gastric tissue. | | 1992 | 1595613 |
| stability of ph gradients in vivo across the stomach in helicobacter pylori gastritis, dyspepsia, and health. | a layer of water-insoluble mucus gel is secreted by the gastric epithelium, and is believed to form an important barrier to acid injury. it is postulated that helicobacter pylori can alter ph gradients by damaging the mucus layer, but no data on ph gradients in vivo in patients with h. pylori gastritis have been published. we aimed to construct a map of mucus-bicarbonate layer ph gradients in health and disease. fourteen healthy asymptomatic volunteers (mean age, 46 yr) and 14 symptomatic patien ... | 1992 | 1595645 |
| effect of sucralfate on the degradation of human gastric mucus by helicobacter pylori protease and lipases. | among the factors implicated in the weakening of mucus perimeter of gastric mucosal defense is helicobacter pylori, the pathogenic action of which appears to be exerted through the elaborated protease and lipase enzymes. we present evidence that the activities of these enzymes are inhibited by an antiulcer agent, sucralfate. the grown colonies of bacteria were washed with saline, filtered through sterilization filter, and the filtrate used as the enzyme source. in the absence of sucralfate, the ... | 1992 | 1595646 |
| large hiatal hernias, anemia, and linear gastric erosion: studies of etiology and medical therapy. | patients with large diaphragmatic hiatal hernias occasionally manifest severe iron deficiency anemia. the etiology is believed to be that of small erosions at the waist of the hernia which bleed slowly. our study attempts to determine the incidence of this condition in clinical practice, and whether acid plays a role in the pathophysiology. sixteen such patients were identified prospectively in a series of 5219 consecutive patients (0.31%) accrued over a 5-yr interval. anemia was the presenting ... | 1992 | 1595651 |
| long-term omeprazole monotherapy is ineffective against helicobacter pylori infection. | | 1992 | 1595667 |
| in vitro activity of antifungal azoles against helicobacter pylori. | | 1992 | 1597211 |
| in vitro susceptibility of helicobacter pylori to nitecapone. | | 1992 | 1597212 |
| helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion. | the effect of helicobacter pylori lipopolysaccharide on guinea pig gastric mucosal pepsinogen secretion has been examined using an ussing chamber technique. luminal addition of h. pylori lipopolysaccharide resulted in a fifty-fold stimulation of pepsinogen secretion compared to a twelve-fold increase with e. coli lipopolysaccharide. electron microscopy showed marked degranulation of zymogen granules but no evidence of chief cell disruption. | 1992 | 1600038 |
| sucralfate diminishes basal acid output without affecting gastrin, h. pylori or gastritis in duodenal ulcer patients. | twelve patients with active duodenal ulcer disease and helicobacter pylori infection were treated with 1 g sucralfate q.d.s. for 1 month. ulcers healed in 8 of the 12 patients without an alteration in the h. pylori-associated antral gastritis. sucralfate produced a significant fall in basal acid output in all the patients, from a median of 4.8 (range 2.1-12.1) to 1.6 (0.4-8) mmol/h, p less than 0.01, whereas peak acid output was unchanged from 41 (21-59) before to 38 (24-55) mmol/h after treatme ... | 1992 | 1600044 |
| review article: the treatment of helicobacter pylori infection. | the discovery of helicobacter pylori has stimulated great interest in its role in gastritis, non-ulcer dyspepsia and peptic ulceration. treatment regimens to eradicate this organism from gastric mucosa have also received considerable attention. current recommendations limit the use of triple drug combinations only to specific patient groups. | 1992 | 1600047 |
| does a previous course of tripotassium dicitrato bismuthate affect the subsequent chances of successful helicobacter pylori eradication? | we have performed a retrospective study of 103 patients with either peptic ulcer or non-ulcer dyspepsia, infected with metronidazole-sensitive strains of helicobacter pylori (h. pylori), who were treated with a combination of tripotassium dicitrato bismuthate and metronidazole for a period of at least two weeks. dual therapy with tripotassium dicitrato bismuthate plus metronidazole showed similarly high eradication rates (greater than or equal to 80%) of h. pylori from patients irrespective of a ... | 1992 | 1600049 |
| short report: twenty-four-hour hyperpepsinogenaemia in helicobacter pylori-positive subjects is abolished by eradication of the infection. | twenty-four-hour plasma pepsinogen i and ii concentrations were determined in 8 healthy subjects with antibody to helicobacter pylori, before and after treatment with tripotassium dicitrato bismuthate, amoxycillin and metronidazole, therapy was successful in the 5 subjects with active h. pylori infection. in these subjects, median integrated 24-h plasma pepsinogen i and ii concentrations significantly decreased from 2288 and 357 micrograms.h/l before treatment, respectively, to 1811 and 171 micr ... | 1992 | 1600055 |
| detection of helicobacter pylori-like organisms in the stomach of some food-source animals using a monoclonal antibody. | to investigate a possible animal reservoir of helicobacter pylori, 15 pigs, 15 rabbits and 5 cows slaughtered for consumption were studied. raised serum igg levels were found in 93% of the pigs and 87% of the rabbits, but levels were normal in the cattle. in the controlled testings three of 22 humans had elevated igg to h pylori and in all three h pylori was detected by the use of monoclonal antibody. helicobacter pylori were identified in gastric brushings by a monoclonal antibody in 8 out of 1 ... | 1992 | 1600192 |
| seroepidemiology of helicobacter pylori infection in vegans and meat-eaters. | an enzyme-linked immunosorbent assay has been used to diagnose serologically the prevalence of helicobacter pylori infection in asian life-long vegans. there was no difference in the seropositivity between these individuals and a group of age- and sex-matched asian meat-eaters, indicating the meat consumption is not a risk factor for h. pylori infection. however, both asian groups had a higher prevalence of infection than age- and sex-matched caucasian meat-eaters. additionally, the asian indivi ... | 1992 | 1601079 |
| adherence of helicobacter pylori to hep-2 cells. | the adherence of 25 strains of helicobacter pylori was evaluated in hep-2 cells. these bacterial isolates, obtained from chilean patients with gastric disorders, were also tested for haemagglutination of human red blood cells. adherence of hep-2 cells was expressed as a common property of all strains, irrespective of whether the cultures were grown on semi-solid or in liquid media. previous reports that haemagglutinating activity was present in cells grown only on semi-solid media were confirmed ... | 1992 | 1602147 |
| helicobacter pyrlori in malawi, central africa. | a total of 160 adult malawians with epigastric pain for longer than 2 weeks was investigated by endoscopy and serologically for evidence of infection with helicobacter pylori. the organism was demonstrated histologically and/or by culture in 141 (88%) patients. with histological means and/or culture as the 'gold standard', the histological technique was 100% sensitive while culture was only 81% sensitive. all isolates tested were sensitive to amoxycillin and tetracycline; 74% were resistant to m ... | 1992 | 1602148 |
| helicobacter pylori and non-ulcer dyspepsia in zambia. | | 1992 | 1604727 |
| [is stomach cancer an infectious disease?]. | | 1992 | 1604913 |
| [evaluation of two commercial kits for detection of helicobacter pylori specific antibodies in patients undergoing gastroscopy. a seroprevalence study in an asymptomatic population]. | we evaluate two different commercially available kits for detecting specific antibodies against helicobacter pylori in a group of 48 patients with gastrointestinal symptoms that underwent an endoscopic procedure. we also study the seroprevalence of anti-h. pylori antibodies in asimptomatic individuals from our area. | 1992 | 1606220 |
| is helicobacter pylori the cause of dyspepsia? | to determine the association between infection with helicobacter pylori and dyspepsia. | 1992 | 1606428 |
| symptoms, gastritis, and helicobacter pylori in patients referred for endoscopy. | acute helicobacter pylori infection is associated with dyspeptic symptoms but chronic infection has not clearly been shown to cause symptoms. to define further the role of h. pylori infection and gastritis in dyspepsia, we interviewed all patients about to undergo upper endoscopy, recorded the primary indication for endoscopy, noted the endoscopic findings, and obtained antral biopsies. among non-ulcer patients there was a strong correlation of acute gastritis with h. pylori. gastritis and h. py ... | 1992 | 1607089 |
| pyloric adenocarcinoma in a ferret. | pyloric adenocarcinoma was diagnosed in a ferret with clinical signs of gastric distention. the development of this tumor may be related to helicobacter mustelae infection in the gastric mucosa of ferrets. pyloric adenocarcinoma has only recently been reported in ferrets and should be considered as a differential diagnosis for gastric distention in this species. | 1992 | 1607319 |
| epidemiology of helicobacter pylori in southern china: identification of early childhood as the critical period for acquisition. | a large cross-sectional study to investigate the prevalence and possible modes of transmission of helicobacter pylori was done in southern china. serum samples (1727) were collected from guangzhou city and three rural areas of guangdong province, and the prevalence of h. pylori infection was determined using an elisa. each subject completed a questionnaire. the overall prevalence of h. pylori infection was 44.2%; a significantly higher prevalence was found in guangzhou (52.4%) than in the rural ... | 1992 | 1607687 |
| [studying the role of helicobacter pylori infection in recurrent abdominal pain in children]. | the authors studied the role of helicobacter pylori at recurrent abdominal pain in childhood. helicobacter pylori infection hasn't been found at the 42 examined children. the endoscopy showed esophagitis in 34 cases. the quick urease test, the histological examination, and the bacterial culture are proposed to carry out in ulcus duodeni, gastritis typ. b ulcus ventriculi and not necessary to carry out if the endoscopy shows only esophagitis--emphasize the authors. | 1992 | 1608607 |
| helicobacter colonization and histopathological profile of chronic gastritis in patients with or without dyspepsia, mucosal erosion and peptic ulcer: a morphological approach to the study of ulcerogenesis in man. | helicobacter pylori colonization and the incidence, severity, activity and topography of gastritis were investigated systematically in antrum and corpus mucosal biopsies of 1177 subjects undergoing endoscopy in the absence of gastric complaints (asymptomatic, 49) or for non-ulcer dyspepsia (nud; 631 patients, 72 of whom had gastric and/or duodenal erosions), active gastric ulcer (gu, 76 patients), active duodenal ulcer (du, 138 patients), and healed gastric (hgu, 39 cases) or duodenal ulcer (hdu ... | 1992 | 1609509 |
| helicobacter pylori and peptic ulcer disease. | | 1992 | 1610319 |
| taxonomy of campylobacter, arcobacter, and helicobacter: a review. | | 1992 | 1611203 |
| 'gastrospirillum hominis', another gastric spiral bacterium. | 'gastrospirillum hominis' is a 'new' tightly coiled gram-negative bacterium carrying bundles of sheathed polar flagella. it has been rather infrequently detected in antral and, even more rarely, in fundic mucosa samples removed at endoscopy from patients investigated for helicobacter pylori colonization. until now, it has remained noncultivable but has successfully been maintained in laboratory mice. its identity with similar bacteria found in the stomachs of cats, dogs, monkeys, pigs, and other ... | 1992 | 1611710 |
| [helicobacter pylori: from harmless commensal to clinically significant disease factor]. | | 1992 | 1611970 |
| the importance of determining both urea and ammonium levels in gastric juice for rapid diagnosis of helicobacter pylori infection. | | 1992 | 1612043 |
| helicobacter pylori and non-ulcer dyspepsia. | | 1992 | 1612344 |
| diagnostic efficiency of an ultra-rapid endoscopy room test for helicobacter pylori. | | 1992 | 1612370 |
| subtypes of intestinal metaplasia and helicobacter pylori. | to determine whether there is a relationship between the presence of h pylori and the various subtypes of intestinal metaplasia in the gastric antrum, 2274 antral gastroscopic biopsies from 533 patients were examined. h pylori was found in 289 patients. intestinal metaplasia in general was found in 135 patients. type i intestinal metaplasia was found in 133 patients (98.5%), type ii in 106 patients (78.5%) and type iii in 21 patients (15.6%). ninety eight of these 135 patients (72.6%) were h pyl ... | 1992 | 1612473 |
| suppression of helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. | helicobacter pylori increases gastrin release in duodenal ulcer patients. this may be through disruption or changes in the mucus layer affecting the access of luminal stimulants to gastrin releasing cells. the effect of suppressing h pylori on gastrin release stimulated by a non-luminal stimulus, gastrin releasing peptide (grp), was examined. eleven patients with active duodenal ulcer disease and colonised with h pylori received an intravenous infusion of grp (2.9 pmol/kg/minute for 30 minutes) ... | 1992 | 1612474 |
| ecology of helicobacter pylori in peru: infection rates in coastal, high altitude, and jungle communities. the gastrointestinal physiology working group of the cayetano heredia and the johns hopkins university. | we have examined endoscopic clinic patients in three widely different geographic regions of peru (the coast, the sierra of the andes mountains, and the amazon jungle) for the presence of helicobacter pylori infection associated with active gastritis. the overall rates of infection were high (80% or greater) in all three zones and rates for men were approximately 10% higher than for women in the same zone. men and women in the sierra and jungle areas had significantly higher rates of infection th ... | 1992 | 1612475 |
| purification of recombinant helicobacter pylori urease apoenzyme encoded by urea and ureb. | helicobacter pylori, a gram-negative, microaerophilic, spiral-shaped bacterium, is an etiologic agent of human gastritis and peptic ulceration and is highly restricted to the gastric mucosa of humans. urease, synthesized at up to 6% of the soluble cell protein, hydrolyzes urea, thereby releasing ammonia, which may neutralize acid, allowing survival of the bacterium and initial colonization of the gastric mucosa. the urease protein is encoded by two subunit genes, urea and ureb; however, accessor ... | 1992 | 1612735 |
| an ultrastructural study of helicobacter mustelae and evidence of a specific association with gastric mucosa. | the ultrastructure of helicobacter mustelae, a natural inhabitant of the ferret stomach, has been studied and compared with the human gastroduodenal pathogen h. pylori. h. mustelae is a short, slightly curved rod, 2 microns x 0.5 micron, with four or more sheathed flagella. the most common flagellar configuration is a single flagellum at one terminus, bipolar arrangement at the other end and a lateral flagellum. dense inclusion bodies were observed below the flagellar insertion sites. it is sugg ... | 1992 | 1613782 |
| [causes of functional dyspepsia]. | | 1992 | 1618112 |