| the hepatitis viral status in patients with hepatocellular carcinoma: a study of 3843 patients from taiwan liver cancer network. | hepatocellular carcinoma (hcc) is the leading cancer death in taiwan. chronic viral hepatitis infections have long been considered as the most important risk factors for hcc in taiwan. the previously published reports were either carried out by individual investigators with small patient numbers or by large endemic studies with limited viral marker data. through collaboration with 5 medical centers across taiwan, taiwan liver cancer network (tlcn) was established in 2005. all participating cente ... | 2016 | 27082566 |
| effects of arsenic in drinking water on risk of hepatitis or cirrhosis in persons with and without chronic viral hepatitis. | arsenic in drinking water is associated with hepatomegaly and death from liver cancer. however, confounding factors related to liver diseases have not been carefully studied. we examined associations between exposure of arsenic in drinking water and risk of hepatitis and cirrhosis, and the interaction with chronic viral hepatitis, in people living in the lanyang basin of northeastern taiwan, where well water has an arsenic content that ranges from undetectable to 3590 μg/l. | 2016 | 27060428 |
| the application of liver stiffness measurement in residents without overt liver diseases through a community-based screening program. | the application of liver stiffness measurement (lsm) by transient elastography (te) in general population remains to clarify. this cohort study aimed to examine the usefulness of te and to identify factors associated with significant liver fibrosis in community-based population.we conducted a hepatitis screening program in 2 remote villages of southern taiwan. all residents participated voluntarily and received questionnaire evaluation, blood tests, abdominal sonography, and lsm by te. residents ... | 2016 | 27015215 |
| anti-hiv seropositivity was related to hbsag seropositivity among injecting drug users in taiwan. | in taiwan, the number of new cases of human immunodeficiency virus (hiv) infection via drug injection has been increasing since 2003. due to hiv and hepatitis b virus (hbv) having similar transmission routes, hbv and hiv infections among injecting drug users (idus) has become an important public health issue. the aim of this study was explore the prevalence of hbv infection among idus with and without hiv infection, and examine whether hiv infection is associated with hbv infection among idus in ... | 2016 | 26944329 |
| early detection of unhealthy behaviors, the prevalence and receipt of antiviral treatment for disabled adult hepatitis b and c carriers. | evidence indicates that hepatitis b virus (hbv) and hepatitis c virus (hcv) infections are the leading causes of liver cirrhosis and hepatocellular carcinoma. antiviral treatments have recently been reported as successful cures. however, the prevalence rates of hbv or hcv infection, unhealthy behaviors and receipt of adequate treatment in disabled adults have not been described. the aim of this study was to examine the prevalence of hbv or hcv carriers, receipt of antiviral treatment, and early ... | 2016 | 26873327 |
| mediation effect of hepatitis b and c on mortality. | hepatitis b (hbv) and c (hcv) viruses cause many liver diseases. to move beyond statistical interaction, we aimed to assess the coordinated effect of the two viruses on mortality using mediation analyses. a prospective cohort study of 3837 residents in taiwan examined participants seropositive for hepatitis b, of which 181 subjects (4.7 %) were co-infected by hcv and 589 died during follow-up. mediation analyses for cause-specific mortality were performed using cox proportional hazards model. fo ... | 2016 | 26792787 |
| general and abdominal adiposity and risk of death in hbv versus non-hbv carriers: a 10-year population-based cohort study. | both obesity and hepatitis b virus (hbv) infection increase the risk of death. we investigate the association between general and central obesity and all-cause mortality among adult taiwanese hbv versus non-hbv carriers.a total of 19,850 hbv carriers and non-hepatitis c virus (hcv) carriers, aged 20 years and older at enrollment in 1998 to 1999 in taiwan, were matched to 79,400 non-hbv and non-hcv carriers (1:4). cox proportional-hazards models were used to estimate the relative risks for all-ca ... | 2016 | 26765398 |
| relationship between chronic hepatitis b and metabolic syndrome: a structural equation modeling approach. | investigate the nature of the relationship between chronic hepatitis b virus (hbv) infection and metabolic syndrome among nondiabetic adults. | 2016 | 26719030 |
| hepatitis c virus infection as a risk factor for parkinson disease: a nationwide cohort study. | to determine whether hepatitis c virus (hcv) infection is a risk factor for developing parkinson disease (pd). | 2016 | 26701382 |
| association between chronic hepatitis b virus infection and risk of osteoporosis: a nationwide population-based study. | the effect of hepatitis b virus (hbv) infection on bone mineral density in patients without advanced liver disease remains unclear. hence, we assessed the association between hbv infection and the risk of osteoporosis. from 2000 to 2011, patients older than 20 years with hbv infection were identified from the longitudinal health insurance database 2000. of the 180,730 sampled patients, 36,146 and 144,584 patients were categorized into hbv infection and comparison cohorts, respectively. compared ... | 2015 | 26683953 |
| annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis b virus infection: a population-based analysis. | this study evaluated hospitalization and mortality in patients with chronic hepatitis b virus infection (hbv (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (vaccine (+)). | 2016 | 26614589 |
| incorporating serum level of hepatitis b surface antigen or omitting level of hepatitis b virus dna does not affect calculation of risk for hepatocellular carcinoma in patients without cirrhosis. | tests for hepatitis b virus (hbv) dna are expensive, and levels of hepatitis b surface antigen (hbsag) can help determine the risk for hepatocellular carcinoma (hcc) in patients with chronic hbv infection. we investigated how adding data to knowing the level of hbsag or excluding measurement of hbv dna affected the accuracy of the risk estimation for hepatocellular carcinoma in chronic hepatitis b (reach-b) scoring system in determining the risk for hcc. | 2016 | 26598229 |
| a simple and rapid test-card method to detect hepatitis b surface antigen and antibody: potential application in young children and infants. | hepatitis b surface antigen (hbsag) and hepatitis b surface antibody (anti-hbs) were conventionally determined by enzyme immunoassays. we aimed to apply a rapid, simple, and accurate method to detect hbsag and its antibody. | 2016 | 26560182 |
| mediation analysis of hepatitis b and c in relation to hepatocellular carcinoma risk. | hepatitis b and c viruses are well-established risk factors for hepatocellular carcinoma (hcc) but their coordinated etiologic mechanism remains unclear. we aimed to assess the mediation effect of the two viruses on hcc risk. | 2016 | 26443934 |
| quality of life and its determinants for heroin addicts receiving a methadone maintenance program: comparison with matched referents from the general population. | quality of life (qol) is found to be lower in heroin addicts; however, few studies examine detailed qol performance and related factors in heroin patients attending a methadone maintenance treatment program (mmtp). the study thus aimed to explore qol and its determinants for publicly-funded and self-paid patients attending an mmtp. | 2016 | 26422442 |
| hepatitis c virus infection associated with an increased risk of deep vein thrombosis: a population-based cohort study. | the association between the hepatitis c virus (hcv) infection and the risk of myocardial infarction (mi) and stroke has been previously investigated. however, the association between the hcv infection and the risk of venous thromboembolism (vte) has not been extensively discussed. using the longitudinal health insurance database 2000 (lhid2000), we selected 3686 patients with newly diagnosed hcv infection. we randomly selected 14,744 people with no hcv or hepatitis b virus (hbv) infection as com ... | 2015 | 26402820 |
| efficacy and resistance to telbivudine treatment in chronic hepatitis b patients with favorable predictors: a multicenter study in taiwan. | a subgroup analysis of a globe study identified subgroups of chronic hepatitis b (chb) patients with excellent outcomes to telbivudine (ldt) treatment. the aim of this study was to validate this concept using a real-world clinical population. | 2016 | 26399763 |
| risk of reverse seroconversion of hepatitis b virus surface antigen in rituximab-treated non-hodgkin lymphoma patients: a large cohort retrospective study. | rituximab causes hepatitis b virus (hbv) reactivation in hbv surface antigen (hbsag)-seronegative patients with cd20-positive b-cell non-hodgkin lymphoma (cd20 nhl), especially for those seropositive to the antibody of core antigen (anti-hbc). clinical hepatitis usually develops after reverse seroconversion of hbsag (hbv-rs), indicated by the reappearance of hbsag in serum. because of the relatively high prevalence of anti-hbc seropositivity in unvaccinated hbsag-seronegative adults in an hbv hy ... | 2015 | 26266374 |
| changing incidence patterns of hepatocellular carcinoma among age groups in taiwan. | this study examined and compared the incidence patterns of hepatocellular carcinoma among age groups in taiwan, 30 years after a universal hepatitis b virus immunization program was launched. | 2015 | 26256438 |
| 13-year nationwide cohort study of chronic kidney disease risk among treatment-naïve patients with chronic hepatitis b in taiwan. | chronic hepatitis b virus (hbv) infection and chronic kidney disease (ckd) have high prevalences in taiwan and worldwide. however, the association of untreated chronic hepatitis b virus (hbv) infection with chronic kidney disease (ckd) remains unclear. | 2015 | 26199000 |
| perspectives on dual hepatitis b and c infection in taiwan. | dual hepatitis c virus (hcv) and hepatitis b virus (hbv) infection is not rare in hbv or hcv endemic areas, and can be found in populations at risk of parenteral viral transmission. clinical observatory studies suggest a higher risk of liver disease progression in patients with dual hcv/hbv infection than in hbv or hcv monoinfected patients. recent trials confirmed that combination therapy of peginterferon alfa-2a or alfa-2b and ribavirin was effective and safe in dually infected patients with p ... | 2016 | 26188762 |
| high risk of hepatitis b reactivation among patients with acute myeloid leukemia. | hepatitis b virus (hbv) infections are common and associated with significant morbidity and mortality in cancer patients. however, the incidence and risk factors of hbv reactivation in patients with acute myeloid leukemia (aml) are rarely investigated. | 2015 | 25973905 |
| efficacy of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant transmission of hepatitis b virus. | the efficacy and safety of maternal tenofovir disoproxil fumarate (tdf) in reducing mother-to-infant hepatitis b virus (hbv) transmissions is not clearly understood. we conducted a prospective, multicenter trial and enrolled 118 hepatitis b surface antigen (hbsag)- and hepatitis b e antigen-positive pregnant women with hbv dna ≥7.5 log10 iu/ml. the mothers received no medication (control group, n = 56, hbv dna 8.22 ± 0.39 log10 iu/ml) or tdf 300 mg daily (tdf group, n = 62, hbv dna 8.18 ± 0.47 l ... | 2015 | 25851052 |
| slow decline of hepatitis b burden in general population: results from a population-based survey and longitudinal follow-up study in taiwan. | hepatitis b virus (hbv) infection poses a global public health threat. hbv vaccination has proven highly effective in preventing the infection; however, its long-term impact on the general population has not been addressed. we conducted analysis to determine the total and changing burden of chronic hbv infection and evaluate the serological status between vaccinated and unvaccinated in taiwan. | 2015 | 25795588 |
| incidence of percutaneous injury in taiwan healthcare workers. | reporting of percutaneous injuries (pis) to the chinese exposure prevention information network (epinet) became mandatory for all public and tertiary referral hospitals in taiwan in 2011. we have estimated the number of microbially contaminated pis and the national pi incidence using a retrospective secondary data analysis approach to analyse 2011 data from the chinese epinet to determine the types of pi, mechanisms of occurrence and associated risks. the results revealed a national estimate of ... | 2015 | 25762054 |
| changing hepatitis d virus epidemiology in a hepatitis b virus endemic area with a national vaccination program. | the emergence of hepatitis d virus (hdv) infection in the era of widespread hbv vaccination has not been described before. we aimed to investigate the changing epidemiology of hdv infection among high- and low-risk populations after an outbreak of human immunodeficiency virus (hiv) infection among injection drug users (idus) in taiwan. a prospective, multicenter, cohort study of 2,562 hepatitis b surface antigen (hbsag)-positive individuals was conducted to determine the prevalence, genotype, an ... | 2015 | 25677884 |
| secular trends were considered in the evaluation of universal hepatitis b vaccination in taiwan. | the objective was to evaluate time-trend bias in the context of a series of studies reporting that a national hepatitis b virus vaccination program (launched in mid-1980s) substantially reduced childhood hepatocellular carcinoma (hcc) incidence. | 2015 | 25660961 |
| what can we learn from hepatitis b virus clinical cohorts? | chronic hepatitis, cirrhosis and hepatocellular carcinoma (hcc) are considered to be sequential adverse outcomes in patients with persistent hepatitis b virus (hbv) infection. hbv infection is endemic in taiwan and most hbv carriers acquire the virus early in life. the impact of hbv factors on the natural course of patients with chronic hbv infection has been investigated in three cohort studies. the first risk evaluation of viral load elevation and associated liver disease/cancer-hepatitis b vi ... | 2015 | 25529093 |
| a nationwide cohort study suggests chronic hepatitis b virus infection increases the risk of end-stage renal disease among patients in taiwan. | the association of chronic hepatitis b virus (hbv) infection with end-stage renal disease (esrd) is unclear. to help clarify this we conducted a nationwide cohort study to measure the association by analyzing the claims data from the taiwan national health insurance research database with icd-9 codes used to identify diseases. we identified 17,758 adults who had chronic hbv infection and had not taken nucleos(t)ide analogs from 1999 to 2010 and randomly selected 71,032 matched controls without h ... | 2015 | 25426815 |
| effect of liver cirrhosis on metastasis in colorectal cancer patients: a nationwide population-based cohort study. | the aim of this study is to evaluate the liver metastasis risk among colorectal cancer patients with liver cirrhosis. | 2015 | 25378650 |
| comparison of the elecsys hbsag ii assay and the architect assay for quantification of hepatitis b surface antigen in chronic hepatitis b patients. | hepatitis b virus (hbv) infection is one of the infections with a highest prevalence in taiwan. the most important marker is hepatitis b surface antigen (hbsag). using the new generation of hbsag quantitative assay, hbsag level may have good correlation with viral activity during different phases of chronic hepatitis b virus infection. this study was conducted to compare two assays of hbsag level to find if the same results are obtained in hbsag quantification in treatment-naïve and on-treatment ... | 2016 | 25355387 |
| incidence and risk factors of skin rashes and hepatotoxicity in hiv-infected patients receiving nevirapine-containing combination antiretroviral therapy in taiwan. | to retrospectively investigate the incidence of and factors associated with skin rashes and hepatotoxicity in hiv-infected patients who initiated combination antiretroviral therapy (cart) containing nevirapine plus two nucleos(t)ide reverse-transcriptase inhibitors. | 2014 | 25312984 |
| scoring systems for predicting mortality after liver transplantation. | liver transplantation can prolong survival in patients with end-stage liver disease. we have proposed that the sequential organ failure assessment (sofa) score calculated on post-transplant day 7 has a great discriminative power for predicting 1-year mortality after liver transplantation. the chronic liver failure-sequential organ failure assessment (clif-sofa) score, a modified sofa score, is a newly developed scoring system exclusively for patients with end-stage liver disease. this study was ... | 2014 | 25216239 |
| nationwide longitudinal analysis of acute liver failure in taiwan. | acute liver failure (alf) is uncommon but fatal. current management is based mostly on clinical experience. we aimed to investigate the incidence, etiology, outcomes, and prognostic factors of alf in taiwan. patients with the admission diagnosis of alf between january 2005 and september 2007 were identified from the longitudinal health insurance database of taiwan. alf was further confirmed by disease severity based on laboratory orders, prescriptions, and duration of hospital stay, and acute on ... | 2014 | 25068951 |
| association of adjuvant antiviral therapy with risk of cancer progression and deaths in patients with hepatitis-b-virus-related hepatocellular carcinoma following curative treatment: a nationwide cohort study. | limited information about tumor status and the time at which antiviral therapy was initiated may have influenced effect estimation in previous research. the aim of this study was to investigate the effect of antiviral therapies on hbv-related hcc progression and deaths in patients receiving curative treatment based on clear clinical-pathological cancer status and the association of start time of adjuvant antiviral therapy initiation and outcomes. | 2014 | 25025231 |
| a genome-wide association study on chronic hbv infection and its clinical progression in male han-taiwanese. | it is common to observe the clustering of chronic hepatitis b surface antigen (hbsag) carriers in families. intra-familial transmission of hepatitis b virus (hbv) could be the reason for the familial clustering of hbsag carriers. additionally, genetic and gender factors have been reported to be involved. we conducted a three-stage genome-wide association study to identify genetic factors associated with chronic hbv susceptibility. a total of 1,065 male controls and 1,623 male hbsag carriers were ... | 2014 | 24940741 |
| prevention of liver cancer through the early detection of risk-related behavior among hepatitis b or c carriers. | hepatitis b virus (hbv) and hepatitis c virus (hcv) infections are the leading causes of liver cirrhosis and hepatocellular carcinoma. little is known about the relationship between health-related behaviors and health status among hbv or hcv carriers. | 2016 | 24836958 |
| hepatitis b and c viruses are not risks for pancreatic adenocarcinoma. | to investigate whether hepatitis b virus (hbv) and hepatitis c virus (hcv) increase risk of pancreatic ductal adenocarcinoma (pdac). | 2014 | 24803819 |
| novel quasi-subgenotype d2 of hepatitis b virus identified in taiwanese aborigines. | the hepatitis b virus (hbv) genomes in taiwanese aborigines, whose ancestors have lived in taiwan for over 10,000 years, have not been characterized. in order to characterize of hbv in this special population, serum samples were obtained from serologically hbsag-positive 27 taiwanese aborigines. the pre-s1/s2 region and the full-length 3.2 kb of the hbv genome were amplified by pcr. obtained amplicons were sequenced and confirmed the hbv genotypes by phylogenetic analysis. by phylogenetic analys ... | 2014 | 24792512 |
| association between hbsag positivity and pancreatic cancer: a meta-analysis. | several studies have proposed an association between hepatitis b and pancreatic cancer. although the spectrum of serological tests varied between studies, hepatitis b virus (hbv) surface antigen (hbsag) test results were consistently reported. this meta-analysis evaluates the association between hbsag positivity and pancreatic cancer. | 2014 | 24788082 |
| association of nucleos(t)ide analogue therapy with reduced risk of hepatocellular carcinoma in patients with chronic hepatitis b: a nationwide cohort study. | treatment for hepatitis b virus infection reduces the risk of hepatocellular carcinoma (hcc). however, the long-term protective effects for subgroups of patients with chronic hepatitis b are unclear. | 2014 | 24704525 |
| clinical characteristics of second primary cancer in colorectal cancer patients: the impact of colorectal cancer or other second cancer occurring first. | due to improvements in early detection, treatment, and supportive care, the number of colorectal cancer (crc) survivors is increasing; therefore, careful attention should always be paid to the second primary cancer (spc) in treating these crc patients. the present study attempts to determine the correlation and clinical aspects of crc to other cancers in patients suffering from spc involving crc. | 2014 | 24678904 |
| comparison of characteristics and transarterial chemoembolization outcomes in patients with unresectable hepatocellular carcinoma and different viral etiologies. | to determine any differences in patient characteristics and outcomes after transarterial chemoembolization between different viral etiologies of hepatocellular carcinoma (hcc). | 2014 | 24468045 |
| higher adherence with 3-year entecavir treatment than lamivudine or telbivudine in treatment-naïve taiwanese patients with chronic hepatitis b. | oral nucleos(t)ide analogs (nas) are effective in suppressing hepatitis b virus (hbv) replication in treatment naïve chronic hepatitis b (chb) patients. however, little is known about the treatment modification and adherence on such patients with prolonged na treatment. | 2014 | 24354995 |
| antituberculosis treatment and hepatotoxicity in patients with chronic viral hepatitis. | whether antituberculosis (anti-tb) treatment in patients with chronic viral hepatitis affects the incidence and onset time of drug-induced hepatotoxicity (dih) is still controversial. the aim of this retrospective study was to find out whether chronic viral hepatitis affects the incidence and onset time of dih. | 2014 | 24292367 |
| clinical and virological features of occult hepatitis b in patients with hbsag seroclearance post-treatment or spontaneously. | occult hepatitis b virus (hbv) infection (ohb) may exist in patients experiencing hepatitis b surface antigen (hbsag) seroclearance. | 2014 | 24119014 |
| high hepatitis b virus surface antigen levels and favorable interleukin 28b genotype predict spontaneous hepatitis c virus clearance in uremic patients. | host and viral factors interplay in the spontaneous clearance of hepatitis c virus (hcv) infection. we aimed to explore the roles of il28b genotypes and hepatitis b virus (hbv) infections in spontaneous hcv seroclearance. | 2014 | 24096049 |
| higher rate of hepatitis events in patients with human immunodeficiency virus, hepatitis b, and hepatitis d genotype ii infection: a cohort study in a medical center in southern taiwan. | the epidemiology and impact of hepatitis δ virus (hdv) on hepatic outcomes and virological and immunological responses to highly active antiretroviral therapy (haart) in human immunodeficiency virus (hiv) patients coinfected with hepatitis b virus (hbv) in northern taiwan have been reported. however, the epidemiology and impact of hdv infection in hiv-hbv coinfection patients in southern taiwan remains uncertain. | 2015 | 24064291 |
| evaluation of abdominal ultrasonography mass screening for hepatocellular carcinoma in taiwan. | mass screening with abdominal ultrasonography (aus) has been suggested as a tool to control adult hepatocellular carcinoma (hcc) in individuals, but its efficacy in reducing hcc mortality has never been demonstrated. this study aimed to assess the effectiveness of reducing hcc mortality by mass aus screening for hcc based on a program designed and implemented in the changhua community-based integrated screening (chcis) program with an efficient invitation scheme guided by the risk score. we invi ... | 2014 | 24002724 |
| inverse association between hepatitis b virus infection and fatty liver disease: a large-scale study in populations seeking for check-up. | although many studies have attempted to clarify the association between hepatitis b virus (hbv) infection and fatty liver disease, no prior studies have emphasized the relationship of hbv and fatty liver regarding different demographics of age and body mass index (bmi). | 2013 | 23991037 |
| national antiviral treatment program and the incidence of hepatocellular carcinoma and associated mortality in taiwan: a preliminary report. | taiwan's bureau of national health insurance launched the national antiviral treatment program (natp) in 2003 to reimburse patients for antiviral drugs and interferons for chronic hepatitis b and c. the objective was to examine the impact of the natp on the incidence and mortality due to hepatocellular carcinoma (hcc). | 2013 | 23969591 |
| diabetes mellitus, metabolic syndrome and obesity are not significant risk factors for hepatocellular carcinoma in an hbv- and hcv-endemic area of southern taiwan. | a prominent factor in hepatocellular carcinoma (hcc) is chronic infection with hepatitis b virus (hbv) and hepatitis c virus (hcv). diabetes mellitus (dm), metabolic syndrome (mets), and obesity have also been implicated in hcc development, but these associations are not observed in all hbv- and hcv-endemic areas. we attempted to clarify the role of these factors in hcc development in an hbv- and hcv-endemic area in southern taiwan. a community-based health examination was conducted in 2004 in t ... | 2013 | 23906236 |
| association between gallbladder stones and chronic hepatitis c: ultrasonographic survey in a hepatitis c and b hyperendemic township in taiwan. | gallbladder (gb) stones have been associated with several metabolic factors and liver diseases. this community-based study aimed at investigating the prevalence rate of gb stones and its associated factors in a hepatitis b virus (hbv)/hepatitis c virus (hcv)-endemic township in southern taiwan. a total of 1701 residents (689 males and 1012 females; mean age: 51.2 ± 16.0 years) were enrolled in this prospectively designed screening project. serum biochemistry tests, including testing for levels o ... | 2013 | 23906233 |
| health care service utilization and associated factors among heroin users in northern taiwan. | due to the needs of medical care, the probability of using health care service from heroin users is high. this cross-sectional study investigated the frequency and correlates of health service utilization among heroin users. from june to september 2006, 124 heroin users (110 males and 14 females, mean age: 34.2 ± 8.3 years) who entered two psychiatric hospitals (n = 83) and a detention center (n = 41) in northern taiwan received a face-to-face interview. therefore, socio-demographic characterist ... | 2013 | 23896066 |
| [the impact of hepatitis b knowledge on screening behavior factors in outpatients]. | according to taiwan department of health and world health organization statistics, hepatic tumors are the second leading cause of death from malignant disease in taiwan, with 600,000 deaths from hbv (hepatitis b virus ) infected complication annually. hepatitis b virus infection is thus an important issue in public health policy. | 2013 | 23729341 |
| hepatocellular carcinoma in patients with chronic kidney disease. | to investigate outcomes of hepatocellular carcinomas (hccs) in patients with chronic kidney disease (ckd). | 2013 | 23674847 |
| synergistic effects of family history of hepatocellular carcinoma and hepatitis b virus infection on risk for incident hepatocellular carcinoma. | little is known about the effects of family history of hepatocellular carcinoma (hcc) on hepatitis b progression or risk of hcc. we examined how family hcc history and presence or stage of hepatitis b virus (hbv) infection affect risk for hcc. | 2013 | 23669307 |
| risk stratification of hepatocellular carcinoma in hepatitis b virus e antigen-negative carriers by combining viral biomarkers. | the serum hepatitis b virus (hbv) surface antigen (hbsag) level can predict hepatocellular carcinoma (hcc) development in hepatitis b e antigen (hbeag)-negative patients with an hbv dna level of <2000 iu/ml. however, little is known regarding how well the combination of both viral biomarkers stratifies hcc risk. | 2013 | 23656977 |
| geographic patterns of hepatocellular carcinoma mortality with exposure to iron in groundwater in taiwanese population: an ecological study. | many studies have examined the risk factors for hcc (including hepatitis b virus, hepatitis c virus, aflatoxin, retinol, cigarette smoking, and alcohol consumption). however, data from previous studies on the association between iron exposure, land subsidence, and hcc mortality/incidence were limited, especially in taiwanese population. we aimed to explore the geographical distribution of hcc mortality rates by township-specific data and to evaluate the association between hcc mortality, land su ... | 2013 | 23590585 |
| cost-effectiveness of augmenting universal hepatitis b vaccination with immunoglobin treatment. | to compare the cost-effectiveness of hepatitis b virus (hbv) control strategies combining universal vaccination with hepatitis b immunoglobulin (hbig) treatment for neonates of carrier mothers. | 2013 | 23530168 |
| serum adiponectin levels are associated with hepatitis b viral load in overweight to obese hepatitis b virus carriers. | this study aimed to investigate the association between serum adiponectin and chronic hepatitis b virus (hbv) infection. | 2013 | 23404868 |
| heavy alcohol consumption increases the incidence of hepatocellular carcinoma in hepatitis b virus-related cirrhosis. | taiwan has a high prevalence of hepatitis b viral (hbv) infection and hepatocellular carcinoma (hcc) with increasing consumption of alcohol. we investigated the impact of heavy alcohol consumption and hbv infection on hcc in cirrhotic patients. | 2013 | 23220252 |
| efficacy of hepatitis b vaccine boosters among neonatally vaccinated university freshmen in taiwan. | long-term protection against hepatitis b virus (hbv) after vaccination remains widely debated. we evaluated the efficacy of a modified 3-dose booster protocol in neonatally vaccinated university students in taiwan. | 2013 | 23207141 |
| association between nucleoside analogues and risk of hepatitis b virus–related hepatocellular carcinoma recurrence following liver resection. | tumor recurrence is a major issue for patients with hepatocellular carcinoma (hcc) following curative liver resection. | 2012 | 23162861 |
| factors associated with ckd in the elderly and nonelderly population. | the risk factors for ckd in different age groups remain unknown. this community-based study aimed to identify the risk factors for ckd in elderly and nonelderly patients. | 2013 | 23085726 |
| hepatocellular carcinoma risk prediction model for the general population: the predictive power of transaminases. | risk prediction models for hepatocellular carcinoma are available for individuals with chronic hepatitis b virus (hbv) and hepatitis c virus (hcv) infections who are at high risk but not for the general population with average or unknown risk. we developed five simple risk prediction models based on clinically available data from the general population. | 2012 | 23073549 |
| serum hepatitis b surface antigen levels help predict disease progression in patients with low hepatitis b virus loads. | chronic hepatitis b patients with high viral loads are at increased risk of cirrhosis and hepatocellular carcinoma (hcc). in patients with low viral loads, higher hepatitis b surface antigen (hbsag) levels have been shown to predict hcc development. however, little is known about the difference in risk for other hepatitis b virus (hbv)-related adverse outcomes with varying hbsag levels. a total of 1,068 taiwanese hepatitis b e antigen (hbeag)-negative hbv carriers with serum hbv dna level <2,000 ... | 2013 | 22941922 |
| seroprevalence of hepatitis virus infection in men who have sex with men aged 18-40 years in taiwan. | men who have sex with men (msm) are at increased risk for hepatitis a virus (hav), hepatitis b virus (hbv), and hepatitis c virus (hcv) infections than the general population. comparisons of the seroprevalence rates of these hepatitis viruses between hiv-positive and hiv-negative msm are rarely performed in taiwan. | 2012 | 22939661 |
| combined effects of hepatitis b virus infection and elevated alanine aminotransferase levels on dyslipidemia. | although elevated alanine aminotransferase (alt) levels are associated with lipid profiles, most studies do not consider the role of hepatitis b virus (hbv) infection. this study investigated the combined effects of hbv infection and elevated alt levels on the lipid profiles of taiwanese adults. | 2013 | 22938729 |
| clinical and virological characteristics post hbsag seroclearance in hepatitis b virus carriers with hepatic steatosis versus those without. | it has been suggested hepatic steatosis contributes to seroclearance of hepatitis b surface antigen (hbsag) in chronic hepatitis b virus (hbv) infection. although hbsag seroclearance generally confers favorable outcome, hepatic steatosis may account for progressive liver fibrosis and cirrhosis. further studies are needed to compare clinical and virological characteristics post hbsag seroclearance between subjects with hepatic steatosis and those without. | 2013 | 22903182 |
| chronic hepatitis b infection in adolescents who received primary infantile vaccination. | hepatitis b virus (hbv) infection is a global health issue. universal infantile hepatitis b (hb) vaccination is very efficacious. however, hbv infections among those immunized subjects have been reported. the long-term efficacy of postnatal passive-active hb vaccination in high-risk subjects is not well explored. a total of 8,733 senior high school students who were born after july 1987 were assayed for hepatitis b surface antigen (hbsag) and antibodies to hbsag (anti-hbs). the overall hbsag and ... | 2013 | 22858989 |
| updated thresholds for serum alanine aminotransferase level in a large-scale population study composed of 34 346 subjects. | the sensitivity of current upper limit of normal (uln) of serum alanine aminotransferase (alt) levels for detecting chronic liver disease has been challenged recently. | 2012 | 22817613 |
| toll-like receptor and hepatitis b virus clearance in chronic infected patients: a long-term prospective cohort study in taiwan. | we sought to elucidate the impacts of the toll-like receptors (tlrs) on spontaneous hepatitis b virus (hbv) e antigen (hbeag) and hepatitis b s antigen (hbsag) seroconversion in chronic hbv-infected patients. | 2012 | 22740716 |
| prevalence of hepatitis b and hepatitis c in patients with chronic schizophrenia living in institutions. | preventing and managing hepatitis b virus (hbv) and hepatitis c virus (hcv) infection is an important public health issue worldwide, and taiwan is one of the countries where viral hepatitis is most endemic. previous studies have shown that patients with serious mental illnesses have a higher risk for hepatitis infection. we investigated the prevalence of hbv and hcv among institutionalized patients with chronic schizophrenia in taiwan. | 2012 | 22721622 |
| minimization of hepatitis b infection by a 25-year universal vaccination program. | hepatitis b virus (hbv) infection was hyperendemic in taiwan before the implementation of the universal infant hepatitis b immunization program, which was launched in 1984. five previous seroepidemiologic surveys were conducted at 0, 5, 10, 15, and 20 years after the launch of the vaccination program. | 2012 | 22668640 |
| global dna methylation levels in white blood cells as a biomarker for hepatocellular carcinoma risk: a nested case-control study. | global dna hypomethylation is associated with genomic instability and human cancer and blood dnas collected at the time of cancer diagnosis have been used to examine the relationship between global methylation and cancer risk. to test the hypothesis that global hypomethylation is associated with increased risk of hepatocellular carcinoma (hcc), we conducted a prospective case-control study nested within a community-based cohort with 16 years of follow-up. we measured methylation levels in satell ... | 2012 | 22581841 |
| increased seroprevalence of hbv dna with mutations in the s gene among individuals greater than 18 years old after complete vaccination. | despite the success of a universal vaccination program against hepatitis b virus (hbv) in taiwan, a small but substantial proportion of individuals remain infected by mutant viruses that escape the vaccine. we investigated the seroepidemiology and genotypic characteristic of hbv for long periods after neonatal vaccination. | 2012 | 22580098 |
| twenty-four year single-center experience of hepatitis b virus infection in heart transplantation. | hepatitis b virus (hbv) infection is hyperendemic in taiwan. we have reported the outcome of (1) recipients with hepatitis b surface antigen (hbsag)-positive; hbsag-negative recipients who receive donor hearts from hbsag-positive donors; and treatment with lamivudine of hepatitis b flare-ups after heart transplantation, using case numbers that range from 100 to 200. | 2012 | 22564582 |
| significance and anamnestic response in isolated hepatitis b core antibody-positive individuals 18 years after neonatal hepatitis b virus vaccination in taiwan. | to investigate the significance of isolated hepatitis b core antibody (anti-hbc) and to analyze the response to hepatitis b virus (hbv) booster vaccination in young adults with isolated anti-hbc who had been fully vaccinated with hbv vaccine as infants. | 2012 | 22531558 |
| association between obesity, hypertriglyceridemia and low hepatitis b viral load. | this study aimed to investigate the metabolic risk factors of high hepatitis b viral load. | 2013 | 22531094 |
| natural history of chronic hepatitis b: what exactly has reveal revealed? | chronic hepatitis b virus (hbv) infection is a serious public health problem because of its worldwide prevalence and potential to cause adverse consequences. the risk evaluation of viral load elevation and associated liver disease/cancer-hepatitis b virus (reveal-hbv) study carried out in taiwan was used to investigate the natural history of chronic hepatitis b. the reveal-hbv study has established an hbv viral load paradigm in the natural history of chronic hepatitis b (chb). serum hbv dna leve ... | 2012 | 22510145 |
| fifteen-year population attributable fractions and causal pies of risk factors for newly developed hepatocellular carcinomas in 11,801 men in taiwan. | development of hepatocellular carcinoma (hcc) is a multi-factorial process. chronic infections with hepatitis b virus (hbv) and hepatitis c virus (hcv) are important risk factors of hcc. host factors, such as alcohol drinking, may also play a role. this study aims to provide a synthesis view on the development of hcc by examining multiple risk factors jointly and collectively. causal-pie modeling technique was applied to analyze a cohort of 11,801 male residents (followed up for 15 years) in tai ... | 2012 | 22506050 |
| latent tuberculosis infection treatment for prison inmates: a randomised controlled trial. | a prison in northern taiwan. | 2012 | 22410137 |
| simultaneous liver and kidney transplantation from different living donors. | to present our experience with simultaneous living donor liver and kidney (slk) transplantation from two different living donors. | 2012 | 22410057 |
| effect of age on the incidence of acute hepatitis b after 25 years of a universal newborn hepatitis b immunization program in taiwan. | raising concerns about the waning immunity of cohorts receiving hepatitis b virus (hbv) vaccination in infancy persuaded us to identify the changing incidence of acute hepatitis b (ahb) in children and young adults. | 2012 | 22262790 |
| efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: subset analyses of the phase iii sorafenib asia-pacific trial. | the phase iii sorafenib asia-pacific (ap) trial-conducted in china, taiwan and south korea - confirmed that sorafenib improves overall survival (os) and is safe for patients with advanced hepatocellular carcinoma (hcc). we performed a series of exploratory subset analyses to determine whether baseline status affected response to sorafenib. | 2012 | 22240282 |
| circulating pattern and genomic characteristics of influenza b viruses in taiwan from 2003 to 2014. | influenza b viruses are antigenically classified into yamagata and victoria lineages according to their hemagglutinin (ha) proteins. these two lineages are known to either appear sequentially or cocirculate in taiwan. | 2016 | 27038555 |
| phylogenetic and evolutionary history of influenza b viruses, which caused a large epidemic in 2011-2012, taiwan. | the annual recurrence of the influenza epidemic is considered to be primarily associated with immune escape due to changes to the virus. in 2011-2012, the influenza b epidemic in taiwan was unusually large, and influenza b was predominant for a long time. to investigate the genetic dynamics of influenza b viruses during the 2011-2012 epidemic, we analyzed the sequences of 4,386 influenza b viruses collected in taiwan from 2004 to 2012. the data provided detailed insight into the flux patterns of ... | 2012 | 23071751 |
| characterization of glycan binding specificities of influenza b viruses with correlation with hemagglutinin genotypes and clinical features. | the carbohydrate binding specificities are different among avian and human influenza a viruses and may affect the tissue tropism and transmission of these viruses. the glycan binding biology for influenza b, however, has not been systematically characterized. glycan binding specificities of influenza b viral isolates were analyzed and correlated to hemagglutinin (ha) genotypes and clinical manifestations. a newly developed solution glycan array was applied to characterize the receptor binding sp ... | 2012 | 22337309 |
| fibrosis-4 index helps identify hbv carriers with the lowest risk of hepatocellular carcinoma. | several viral and host risk factors have been used to predict risks of hepatocellular carcinoma (hcc) in patients with chronic infection of hepatitis b virus (hbv). however, little is known whether fibrosis-4 (fib-4) index, a liver fibrosis biomarker, helps identify non-cirrhotic patients with the lowest hcc risk. | 2017 | 28853728 |
| the impact of chronic hepatitis b infection on major adverse cardiovascular events and all-cause mortality in patients with diabetes: a nationwide population-based study from taiwan. | the association between hepatitis b virus (hbv) infection and cardiovascular disease remains uncertain. this study explored long-term hard endpoints (ie, myocardial infarction and ischaemic stroke) and all-cause mortality in diabetic patients with chronic hbv infection in taiwan from 2000 to 2013. | 2017 | 28827251 |
| real-world effectiveness and safety of paritaprevir/ritonavir, ombitasvir, and dasabuvir with or without ribavirin for patients with chronic hepatitis c virus genotype 1b infection in taiwan. | the real-world effectiveness and safety of paritaprevir/ritonavir, ombitasvir, and dasabuvir (prod) remain limited for east asian hepatitis c virus genotype 1b (hcv-1b) patients. we aimed to evaluate the anti-viral responses of prod-based regimens for hcv-1b patients in taiwan. | 2017 | 28762541 |
| influence of metabolic risk factors on risk of hepatocellular carcinoma and liver-related death in men with chronic hepatitis b: a large cohort study. | little is known about the absolute risk of hepatocellular carcinoma (hcc) and liver-disease related death, in association with metabolic risk factors, for patients with hepatitis b virus (hbv) infection. | 2017 | 28711626 |
| genome-wide association analysis identifies a glul haplotype for familial hepatitis b virus-related hepatocellular carcinoma. | a family history of liver cancer increases the risk of developing hepatocellular carcinoma (hcc) by 2-fold to 10-fold among patients with chronic hepatitis b virus (hbv). previous genome-wide association studies have identified many possible susceptible loci associated with sporadic hbv-related hcc. however, despite family history being a well-known risk factor for hbv-related hcc, to the authors' knowledge its genetic mechanisms and associating loci remain largely unknown or unexplored, most li ... | 2017 | 28662289 |
| predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis. | the high seroprevalence of human herpesvirus type 8 (hhv-8) in moderate or severe cirrhotics appears to be associated with male sex, hepatitis b virus (hbv) infection, alcoholism, and disease severity. the status of hhv-8 infection in mild cirrhotics remains unclear. plasma samples collected from 93 mild cirrhotics and 93 age- and sex-matched healthy controls were analyzed for hhv-8 antibody and hhv-8 dna. mild cirrhotics had higher seropositivity for hhv-8 antibodies than healthy controls (p=0. ... | 2017 | 28588294 |
| adult mortality of diseases and injuries attributable to selected metabolic, lifestyle, environmental, and infectious risk factors in taiwan: a comparative risk assessment. | to facilitate priority-setting in health policymaking, we compiled the best available information to estimate the adult mortality (>30 years) burden attributable to 13 metabolic, lifestyle, infectious, and environmental risk factors in taiwan. | 2017 | 28473740 |
| adult mortality of diseases and injuries attributable to selected metabolic, lifestyle, environmental, and infectious risk factors in taiwan: a comparative risk assessment. | to facilitate priority-setting in health policymaking, we compiled the best available information to estimate the adult mortality (>30 years) burden attributable to 13 metabolic, lifestyle, infectious, and environmental risk factors in taiwan. | 2017 | 28468625 |
| phenotypic and genotypic shifts in hepatitis b virus in treatment-naive patients, taiwan, 2008-2012. | we examined the characteristic changes of hepatitis b virus (hbv) in antiviral drug treatment-naive patients referred for pretreatment evaluation in taiwan during 2008-2012. over time, we observed substantial decreases in the prevalence of hbv e antigen (hbeag) and increasing prevalence of the precore g1899a mutation and hbv-dna levels in hbeag-positive patients. | 2017 | 28418295 |
| the isolation and characterization of a new influenza type b virus on taiwan. res rep mr005.09-1201.4.7. | | 1963 | 24547136 |
| efficacy of ledipasvir and sofosbuvir treatment of hcv infection in patients coinfected with hbv. | there have been reports of reactivation of hepatitis b virus (hbv) infection during treatment of hepatitis c virus (hcv) infection with direct-acting antiviral agents. we performed a prospective study of risks and outcomes of hcv infection treatment with ledipasvir and sofosbuvir in patients with hbv infection. | 2018 | 29174546 |