| mapping epitopes of u1-70k autoantibodies at single-amino acid resolution. | the mechanisms underlying development of ribonucleoprotein (rnp) autoantibodies are unclear. the u1-70k protein is the predominant target of rnp autoantibodies, and the rna binding domain has been shown to be the immunodominant autoantigenic region of u1-70k, although the specific epitopes are not known. to precisely map u1-70k epitopes, we developed silicon-based peptide microarrays with >5700 features, corresponding to 843 unique peptides derived from the u1-70k protein. the microarrays featur ... | 2015 | 26333287 |
| immunogenicity and safety of a cell culture-derived inactivated trivalent influenza vaccine (nbp607): a randomized, double-blind, multi-center, phase 3 clinical trial. | cell culture-derived influenza vaccines (ccivs) have several important advantages over egg-based influenza vaccines, including shorter production time, better preservation of wild-type virus antigenicity and large-scale production capacity. | 2015 | 26314625 |
| increased prevalence of influenza b/victoria lineage viruses during early stages of the 2015 influenza season in new south wales, australia: implications for vaccination and planning. | during the early weeks of the 2015 australian influenza season, influenza b accounted for 67% (821/1,234) of all positive influenza tests in new south wales. of 81 successive influenza b viruses characterised, 33 (41%) were from children aged < 16 years; 23/81 (28%) belonged to the b/victoria lineage. this lineage is not contained in the southern hemisphere's 2015 trivalent influenza vaccine. the significant b/victoria lineage activity in the southern hemisphere suggests that the quadrivalent va ... | 2015 | 26290426 |
| phase i clinical evaluation of seasonal influenza hemagglutinin (ha) dna vaccine prime followed by trivalent influenza inactivated vaccine (iiv3) boost. | annual influenza vaccination reduces the risks of influenza when the vaccines are well matched to circulating strains, but development of an approach that induces broader and more durable immune responses would be beneficial. we conducted two companion phase 1 studies, vrc 307 and vrc 309, over sequential seasons (2008-2009 and 2009-2010) in which only the influenza b strain component of the vaccines differed. objectives were safety and immunogenicity of prime-boost vaccination schedules. a sche ... | 2015 | 26275339 |
| retrospective public health impact of a quadrivalent influenza vaccine in the united states. | vaccination is an effective preventive strategy against influenza. however, current trivalent influenza vaccines (tivs) contain only one of the two influenza b lineages that circulate each year. vaccine mismatches are frequent because predicting which one will predominate is difficult. recently licensed quadrivalent influenza vaccines (qivs) containing the two b lineages should address this issue. our study estimates their impact by assessing what would have been the us public health benefit of ... | 2015 | 26256294 |
| an assessment of the expected cost-effectiveness of quadrivalent influenza vaccines in ontario, canada using a static model. | ontario, canada, immunizes against influenza using a trivalent inactivated influenza vaccine (iiv3) under a universal influenza immunization program (uiip). the uiip offers iiv3 free-of-charge to all ontarians over 6 months of age. a newly approved quadrivalent inactivated influenza vaccine (iiv4) offers wider protection against influenza b disease. we explored the expected cost-utility and budget impact of replacing iiv3 with iiv4, within the context of ontario's uiip, using a probabilistic and ... | 2015 | 26222538 |
| an interesting case of viral pericarditis. | a previously healthy 14-year-old girl presented to the emergency department with a 3-day history of upper respiratory symptoms and 2 syncopal episodes. she was initially febrile, tachycardic, and tachypneic; the initial electrocardiogram showed diffuse t-wave inversions and right atrial enlargement. there was no pericardial effusion on bedside and formal echocardiography; the latter, however, revealed a hyperechogenic pericardium. a viral swab was positive for influenza b. treatment with intrave ... | 2016 | 26181497 |
| [susceptibility of influenza b viruses to neuraminidase inhibitors isolated during 2013-2014 influenza season in mainland china]. | data based on the antiviral-resistant phenotyping characteristics of 884 influenza b viruses circulating in mainland china from october 2013 to march 2014 were analyzed to assess the susceptibility of influenza b viruses to neuraminidase inhibitors. all 884 viruses were sensitive to oseltamivir; two viruses (0.23%) had reduced sensitivity to zanamivir and all other viruses were sensitive to zanamivir. among the 38 viruses with a b/victoria lineage, b/shandong-kuiwen/1195/2014 exhibited a half-ma ... | 2015 | 26164940 |
| only a touch of the flu? the simultaneous manifestation of acute necrotizing encephalopathy in two consanguineous patients. | this case report describes the simultaneous manifestation of acute necrotizing encephalopathy in 2 consanguineous patients after infection with influenza b based on the autosomal dominant missense mutation of the ranbp2-gene. differential diagnosis of acute encephalopathy, clinical and radiological clues, and treatment strategies are outlined. | 2015 | 26110162 |
| toward improved influenza control through vaccination. | in august 27/2014, slipe organized the master class "towards improved influenza control through vaccination", a panel with international influenza experts who shared their understanding of the disease and the control measures available, focusing on the most recent information about this serious diseases. in this report dr falleiros and dr bricks summarized the following topics: global influenza epidemiology, presented by dr puig-barbera; influenza vaccine recommendations and coverage in latin am ... | 2015 | 26065453 |
| surveillance of acute respiratory infections among outpatients: a pilot study in isfahan city. | considering that there was not any regional survey in isfahan, iran regarding the epidemiology of acute respiratory tract infections (arti) in different age groups of general population, the aim of this study was to determine the epidemiologic feature of artis in isfahan using multiplex polymerase chain reaction (pcr) method. | 2015 | 25983761 |
| plastic bronchitis arising from solitary influenza b infection: a report of two cases in children. | plastic bronchitis (pb) is characterized by thick, inspissated, tracheobronchial casts. it is classified as either inflammatory or acellular based on the content of the endobronchial casts. pb has never been reported in a healthy child with solitary influenza b infection. this study is a retrospective case series of two children who presented to our institution in acute respiratory distress. emergency rigid bronchoscopy was performed with extraction of casts from the l mainstem bronchus in both ... | 2015 | 25957780 |
| a case of acute kidney injury and disseminated intravascular coagulation associated with influenza b viral infection. | there are few reports of acute kidney injury (aki) associated with influenza viral infection. we treated a case of aki that developed after an influenza b viral infection. a 35-year-old man visited a local physician for a fever and was diagnosed with influenza b. he was prescribed laninamivir, then returned to the physician 5 days later with dyspnea and was referred to hospital a. upon admission, respiratory arrest developed, for which he received tracheal intubation and mechanical ventilation. ... | 2015 | 28509280 |
| oseltamivir-warfarin interaction in hypoplastic left heart syndrome: case report and review. | an 8-year-old boy with hypoplastic left heart syndrome with a previous history of thrombosis within the inferior vena cava receiving stable warfarin dosing for anticoagulation was diagnosed with influenza b. he was subsequently placed on oseltamivir therapy according to the centers for disease control and prevention clinical practice guidelines. during the hospitalization, his international normalized ratio steadily increased to supratherapeutic levels and returned to baseline after discontinuat ... | 2015 | 25917992 |
| live attenuated influenza vaccine tetravalent: a clinical review. | live attenuated influenza vaccine (laiv) has been available as a trivalent formulation in the eu since 2012. influenza b strains from two lineages have co-circulated outside asia in europe, israel and north america since the early 2000s. the trivalent vaccine contained a single influenza b lineage virus chosen primarily on the basis of the previous year's circulating lineage. failure to align the vaccine virus with the circulating virus leaves even vaccinated patients, particularly children, at ... | 2015 | 25864428 |
| cost-effectiveness of quadrivalent influenza vaccine in hong kong - a decision analysis. | trivalent influenza vaccine (tiv) selects one of the 2 co-circulating influenza b lineages whereas quadrivalent influenza vaccine (qiv) includes both lineages. we examined potential cost-effectiveness of qiv versus tiv from perspectives of healthcare provider and society of hong kong. a decision tree was designed to simulate the outcomes of qiv vs. tiv in 6 age groups: 0-4 years, 5-9 years, 10-14 years, 15-64 years, 65-79 y and ≥80 years. direct cost alone, direct and indirect costs, and quality ... | 2015 | 25714506 |
| mild encephalopathy with reversible splenial lesion: an important differential of encephalitis. | mild encephalopathy with a reversible splenial lesion (mers) is a clinico-radiological syndrome characterized by a transient mild encephalopathy and a reversible lesion in the splenium of the corpus callosum on mri. this syndrome has almost universally been described in children from japan and east asia. here we describe seven cases of mers occurring in caucasian australian children from one centre seen over a 3 year period. all patients had a fever-associated encephalopathy (n = 7), which prese ... | 2015 | 25707871 |
| influenza virus surveillance among young children in são paulo, brazil: the impact of vaccination. | this study assessed the presence of influenza virus among young children and the coverage of vaccination from 2010 to 2012 in são paulo, brazil. our results demonstrated a lower rate of influenza detection and a predominance of influenza b. a decrease of coverage vaccination through the surveillance periods was observed. | 2014 | 25477951 |
| descriptive epidemiology of school outbreaks of seasonal influenza b during 2012/2013 in the thames valley, united kingdom. | | 2014 | 25443101 |
| cost-effectiveness analysis of quadrivalent influenza vaccine versus trivalent influenza vaccine for elderly in hong kong. | cost and quality-adjusted life-years (qalys) gained by quadrivalent influenza vaccine (qiv) versus trivalent influenza vaccine (tiv) in hong kong elderly were estimated over 9 seasons. | 2014 | 25420713 |
| case series of rash associated with influenza b in school children. | this case series describes morbilliform and other rash presentations among schoolchildren during a march 2014 outbreak of influenza-like illness (ili) in british columbia, canada. multiplex nucleic acid testing of nasopharyngeal specimens and paired serologic investigations identified that influenza b, characterized as b/massachusetts/02/2012-like (yamagata-lineage), was the only viral aetiology and most likely cause of ili and rash. an association between influenza b and rash has been described ... | 2015 | 25382064 |
| burden of influenza b in 9 european countries: a literature review. | | 2014 | 27202435 |
| impact of influenza b in france. | | 2014 | 27201811 |
| reassortment between influenza b lineages and the emergence of a coadapted pb1-pb2-ha gene complex. | influenza b viruses make a considerable contribution to morbidity attributed to seasonal influenza. currently circulating influenza b isolates are known to belong to two antigenically distinct lineages referred to as b/victoria and b/yamagata. frequent exchange of genomic segments of these two lineages has been noted in the past, but the observed patterns of reassortment have not been formalized in detail. we investigate interlineage reassortments by comparing phylogenetic trees across genomic s ... | 2015 | 25323575 |
| interactions of lipids and detergents with a viral ion channel protein: molecular dynamics simulation studies. | structural studies of membrane proteins have highlighted the likely influence of membrane mimetic environments (i.e., lipid bilayers versus detergent micelles) on the conformation and dynamics of small α-helical membrane proteins. we have used molecular dynamics simulations to compare the conformational dynamics of bm2 (a small α-helical protein from the membrane of influenza b) in a model phospholipid bilayer environment with its behavior in protein-detergent complexes with either the zwitterio ... | 2015 | 25286030 |
| [severe upper abdominal pain during a long distance flight]. | a 43-year-old woman of ghanaian origin presented with severe upper abdominal pain starting on a long distance flight. physical examination revealed tenderness on palpation in the left upper abdomen and flank. there was no report of pre-existing conditions or permanent medication in the medical history. | 2014 | 25254402 |
| influenza vaccine effectiveness estimates for western australia during a period of vaccine and virus strain stability, 2010 to 2012. | during 2010-2012 the strain composition of the influenza vaccine in the southern hemisphere did not change, but the circulating virus type/subtype did. we pooled data for these years from the western australian sentinel medical practice surveillance system for influenza to estimate vaccine effectiveness (ve) by influenza virus type and subtype. a case test-negative design was used with ve estimated as (1-odds ratio)×100%. there were 2182 patients included in the analysis across the 3 years studi ... | 2014 | 25223268 |
| influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel australian hospitals in 2013: the influenza complications alert network. | the national influenza program aims to reduce serious morbidity and mortality from influenza by providing public funding for vaccination to at-risk groups. the influenza complications alert network (flucan) is a sentinel hospital-based surveillance program that operates at 14 sites in all states and territories in australia. this report summarises the epidemiology of hospitalisations with confirmed influenza, estimates vaccine coverage and influenza vaccine protection against hospitalisation wit ... | 2014 | 25222208 |
| using daily syndrome-specific absence data for early detection of school outbreaks: a pilot study in rural china. | this paper describes and preliminarily evaluates the usefulness of the daily syndrome-specific absenteeism surveillance system (dssass) as an early warning system of school outbreaks in rural china. | 2014 | 25200208 |
| risk factors for hospitalization among children with influenza b infection. | data regarding risk factors for hospitalization among children with influenza b infection are limited. we conducted a retrospective study of 184 children with influenza b infection during october 2011 - september 2012 seen at bamrasnaradura infectious diseases institute, thailand; clinical and laboratory data were compared between hospitalized and outpatient children. the numbers of hospitalized and outpatient children were 65 (35%) and 119 (65%), respectively. most children (> 80%) were aged > ... | 2014 | 24974646 |
| high percentage of false-positive results for influenza b obtained with a rapid influenza point-of-care test. | | 2014 | 24795330 |
| analysis of medical consultation interval between the symptom onset and consultation observed in multiple medical facilities in odate city, japan, 2011/2012 and 2012/2013 seasons. | influenza remains one of the most important causes of respiratory infection despite the widespread availability of vaccines. anti-influenza viral agents such as neuraminidase inhibitors are generally efficacious in alleviating the symptoms if they are administered within 2 days of the illness onset. however, few studies have examined the situation of interval between illness onset and medical consultation in influenza outpatients on community level. and the predictors or determinants for longer ... | 2014 | 24725622 |
| molecular epidemiologic and clinical characteristics of influenza b-associated complications among hospitalized patients during an outbreak in taiwan. | to study the resurgence of influenza b/yam in taiwan and summarize clinical findings of influenza b-associated complications among hospitalized patients, in particular the link between clinical and molecular epidemiologic characteristics. | 2014 | 24721164 |
| [case of non-convulsive status epilepticus after influenza virus b infection]. | a 24-year-old woman was referred to our hospital because of impaired consciousness after influenza virus b infection. neurological examination revealed mild disturbance of consciousness without other neurological abnormalities. laboratory tests showed elevated serum crp, il-6 and tnf-α levels. the level of il-6 in the cerebrospinal fluid was also slightly elevated. electroencephalography (eeg) disclosed almost continuous generalized spike and wave complexes and multiple spikes and wave complexes ... | 2014 | 24705838 |
| influenzavirus b-associated acute benign myalgia cruris: an outbreak report and review of the literature. | acute benign myalgia cruris is characterized by transient bilateral calf pain that leads to difficulty walking. a regional outbreak of influenza virus b-associated myalgia cruris was observed during the seasonal influenza outbreak observed in switzerland from week 1 to 13 of 2013. we performed a prospective case finding among the swiss-italian pediatric emergency units and pediatricians. a review of the literature was also performed. the diagnosis of myalgia cruris was made in 49 swiss-italian c ... | 2014 | 24530048 |
| morphology of influenza b/lee/40 determined by cryo-electron microscopy. | cryo-electron microscopy projection image analysis and tomography is used to describe the overall architecture of influenza b/lee/40. algebraic reconstruction techniques with utilization of volume elements (blobs) are employed to reconstruct tomograms of this pleomorphic virus and distinguish viral surface spikes. the purpose of this research is to examine the architecture of influenza type b virions by cryo-electron tomography and projection image analysis. the aims are to explore the degree of ... | 2014 | 24516628 |
| co-infection of influenza b and streptococcus. | | 2014 | 24473695 |
| [preliminary establishment of an electrochemiluminescence immunoassay method for detection of influenza virus b]. | to establish an electrochemiluminescence immunoassay (eclia) for the detection of influenza virus b (flu b), we biotinylated the flu b monoclonal antibody (mab),labeled the paired ab with ruthenium and used the streptavidin-coated microparticles in this study. the ecl intensity was linear with the concentrations of antigen of flu b in the range of 0.55 microg/ml to 17.5 microg/ml, with a detection limit of 0.55 microg/ml (s/n= 3). the precision,sensitivity and specificity were evaluated. the est ... | 2013 | 24459953 |
| safety and immunogenicity of an inactivated quadrivalent influenza vaccine in children 6 months through 8 years of age. | strains of 2 distinct influenza b lineages (victoria and yamagata) have cocirculated in the united states for over a decade, but trivalent influenza vaccines (tivs) contain only 1 b-lineage strain. each season, some or most influenza b disease is caused by the b lineage not represented in that season's tiv. quadrivalent influenza vaccines (qivs) containing a strain from each b lineage should resolve this problem. | 2014 | 24445833 |
| economic burden of seasonal influenza b in france during winter 2010-2011. | in france, 2-15% of the population is affected annually by influenza, which causes significant socioeconomic disruption. nevertheless, despite its importance for policy makers, few published studies have evaluated the impact of influenza b. therefore, we assessed the costs associated with influenza b during 2010-2011 in france. | 2014 | 24443900 |
| influenza-b associated rhabdomyolysis with acute renal failure. | | 2013 | 24413511 |
| whole-genome analysis of influenza b viruses of multiple genotypes cocirculating in india. | systematic influenza virus surveillance has been carried out in india since 2004 and has revealed the cocirculation of type b lineages. the genetic diversity of influenza b viruses was observed when full-genome analysis was performed. in 2010, the cocirculation of multiple genotypes was observed. | 2013 | 24285663 |
| generation of anti-influenza aptamers using the systematic evolution of ligands by exponential enrichment for sensing applications. | the systematic evolution of ligands by exponential enrichment (selex) is a selection process for identifying high-affinity selective molecules from a randomized combinatorial nucleic acid library against a wide range of target molecules. using a pool of n25 rna molecules, the selex process was performed against two targets from influenza viruses, namely, intact influenza b/tokio/53/99 and hemagglutinin of infuluenza b jilin/20/2003. the selection processes were evaluated by surface plasmon fluor ... | 2013 | 24200095 |
| laboratory-confirmed influenza b infection in immunized long-term care facility residents receiving oseltamivir prophylaxis in ontario. | we report on an influenza b outbreak in an ontario long-term care facility in which 2 immunized residents receiving oseltamivir prophylaxis for at least 5 days developed laboratory-confirmed influenza b infection. all isolates were tested for the most common oseltamivir resistance, and none of them had resistance identified. | 2013 | 24113612 |
| unusually high impact of influenza b during the early 2012-2013 influenza season in wales--epidemiology and clinical analysis of the first 100 cases. | influenza b is often regarded as the milder form of the disease. the early 2012-2013 season in wales saw the highest rate of influenza b-associated primary care consultations since 1994-1995 and considerable hospitalisations. | 2013 | 24034594 |
| influenza-b associated rhabdomyolysis and acute renal failure. | we present a 15 year old boy who developed severe rhabdomyolysis and acute renal failure following influenza b infection. his renal function was restored after appropriate therapy for rhabdomyolysis. although rapidly progressive pneumonia, respiratory failure, and acute respiratory distress syndrome are the most common severe complications of influenza b infection, clinicians should be aware that influenza b may be complicated with rhabdomyolysis and acute renal failure in children. | 2013 | 23942401 |
| [vaccination in adult patients with chronic inflammatory rheumatic diseases]. | patients with chronic inflammatory rheumatic diseases often have an intrinsic and therapy associated increased susceptibility to infections which substantially contributes to morbidity and mortality of the patients. a large proportion of these infections are preventable by vaccination. for this reason in 2005 the standing vaccination committee (stiko) recommended for patients with immunosuppression vaccination against pneumococcus, influenza, haemophilus influenza b and meningococcus in addition ... | 2013 | 23929239 |
| evolutionary pattern of reemerging influenza b/victoria lineage viruses in são paulo, brazil, 1996-2012: implications for vaccine composition strategy. | since the 1980s, 2 antigenically distinct influenza b lineages have cocirculated in the world: b/victoria/2/87 (first appeared in the 1980s) and b/yamagata/16/88 (became predominant in the 1990s). b/victoria/2/87 isolates were geographically restricted to eastern asia during 1991-2000. during 2000-2001 and 2001-2002, b/victoria/2/87 isolates reemerged in north america, europe, and south america, and then spread globally. during influenza virus surveillance, season 2002, an outbreak of acute resp ... | 2013 | 23926069 |
| neurological and muscular manifestations associated with influenza b infection in children. | influenza viruses have been associated with various neurological and muscular symptoms. the aim of this study was to evaluate the pediatric neurological and muscular manifestations of influenza b during a 5-month epidemic at a single center. | 2013 | 23859854 |
| [case report; co-infection with mycoplasma and influenza b resulting in a guillain-barré syndrome with anti-galactocerebroside antibody]. | | 2013 | 23847989 |
| the quadrivalent approach to influenza vaccination. | | 2013 | 23847061 |
| [benign acute myositis in a 17-year-old boy]. | we describe the case of a 17-year-old teenager who consulted in an emergency unit for acute lateral chest pain with tumefaction. the boy was healthy and had no medical problems or allergies. upon awakening, he felt faintness and a left lateral chest pain. movement of the left shoulder was difficult. in the emergency department, the clinical examination showed a painful left axillary mass, normal respiratory and heart function, and normal clinical parameters. biological assessment revealed substa ... | 2013 | 23726681 |
| comparison of the reactogenicity of three different immunization schedules including diphtheria, tetanus, pertussis, haemophilus influenza b and polio vaccine in turkey. | in turkey, several changes have been made in the vaccination schedule. vaccines against diphtheria, tetanus, pertussis and poliomyelitis were applied as dtwp and opv until the end of 2006. hib vaccine was added to the schedule and was administered as a separate injection in 2007 as dpt + opv + hib. dtap-ipv/hib combined vaccine replaced them in 2008. the aim of this study was to evaluate the alterations in the frequency of adverse reactions of these different schedules in the consecutive three y ... | 2013 | 23720155 |
| the use of pyrosequencer-generated sequence-signatures to identify the influenza b-lineage and the subclade of the b/yamataga-lineage viruses from currently circulating human influenza b viruses. | influenza b viruses belong to two antigenically and genetically distinct lineages which co-circulate in varying proportions in many countries. | 2013 | 23692962 |
| vaccine adverse events reported during the first ten years (1998-2008) after introduction in the state of rondonia, brazil. | despite good safety records, vaccines given to young children can cause adverse events. we investigated the reported adverse events following immunization (aefi) of vaccines given to children of less than seven years of age during the first ten years (1998 to 2008) in the state of rondonia, brazil. we worked with the events related to bcg (bacillus calmett-guérin), hb (hepatitis b), dtwp/hib (diphtheria-tetanus-pertussis+hemophillus influenza b), dtp (diphtheria-tetanus-pertussis), mmr (mumps, m ... | 2013 | 23509790 |
| early estimates of influenza vaccine effectiveness in navarre, spain: 2012/13 mid-season analysis. | we present estimates of influenza vaccine effectiveness (ve) in navarre, spain, in the early 2012/13 season, which was dominated by influenza b. in a population-based cohort using electronic records from physicians, the adjusted ve in preventing influenzalike illness was 32% (95% confidence interval (ci): 15 to 46). in a nested test-negative case-control analysis the adjusted ve in preventing laboratory-confirmed influenza was 86% (95% ci: 45 to 96). these results suggest a high protective effec ... | 2013 | 23449182 |
| exploring the proton conductance and drug resistance of bm2 channel through molecular dynamics simulations and free energy calculations at different ph conditions. | bm2 channel plays an important role in the replication of influenza virus b. however, few studies attempt to investigate the mechanism of the proton conductance in bm2 channel, as well as the drug resistance of the bm2 channel. the first experimental structure of the bm2 protein channel has recently been solved, enabling us to theoretically study bm2 systems with different protonation states of histidine. by performing molecular dynamics simulations on the bm2 systems with different protonation ... | 2013 | 23286443 |
| safety and immunogenicity of a quadrivalent inactivated influenza vaccine compared to licensed trivalent inactivated influenza vaccines in adults. | to evaluate the safety and immunogenicity of a prototype quadrivalent inactivated influenza vaccine (qiv) containing two influenza b strains, one of each lineage, compared with licensed trivalent inactivated influenza vaccines (tivs) containing either a victoria b-lineage strain (2009-2010 tiv) or a yamagata b-lineage strain (2008-2009 tiv). | 2013 | 23228813 |
| colorimetric viral detection based on sialic acid stabilized gold nanoparticles. | sialic acid reduced and stabilized gold nanoparticles (d=20.1±1.8 nm) were synthesized by a simple one-pot, green method without chemically modifying sialic acid for colorimetric detection of influenza virus. the gold nanoparticles showed target-specific aggregation with viral particles via hemagglutinin-sialic acid binding. a linear correlation was observed between the change in optical density and dilution of chemically inactivated influenza b/victoria and influenza b/yamagata. virus dilution ... | 2013 | 23208092 |
| the economic value of a quadrivalent versus trivalent influenza vaccine. | the recently licensed quadrivalent seasonal influenza vaccine (qiv) may provide better protection than the traditional trivalent influenza vaccine (tiv) as it includes one more influenza b strain. we developed a monte carlo simulation model to determine the economic value of a qiv compared to the tiv for 10 influenza seasons (1999-2009). the addition of the influenza b strain to convert the tiv into a qiv could result in substantial cost-savings to society (median of $3.1 billion) and third part ... | 2012 | 23084849 |
| influenza b lineage circulation and hospitalization rates in a subtropical city, hong kong, 2000-2010. | a need for quadrivalent vaccines to cover both lineages of influenza b has been raised. information on the circulation status of influenza b lineages and the associated hospitalization rates is important to assist evidence-based decision making. this retrospective study revealed the situation in a subtropical city over a 10-year period. | 2013 | 23074315 |
| immunogenicity of a quadrivalent ann arbor strain live attenuated influenza vaccine delivered using a blow-fill-seal device in adults: a randomized, active-controlled study*. | influenza b strains from two distinct lineages (yamagata and victoria) have cocirculated over recent years. current seasonal vaccines contain a single b lineage resulting in frequent mismatches between the vaccine strain and the circulating strain. an ann arbor strain quadrivalent live attenuated influenza vaccine (q/laiv) containing b strains from both lineages is being developed to address this issue. | 2013 | 23061976 |
| molecular characterization of influenza b viruses isolated in east-central china in 2009-2010. | the current circulating influenza b viruses can be divided into two major phylogenetic lineages: the victoria and yamagata lineages. we conducted a survey of influenza b viruses in hubei and zhejiang provinces during 2009-2010. out of 341 throat swabs, 18 influenza b viruses were isolated. five isolates were selected for genetic and phylogenetic analysis. the molecular analyses revealed that all the isolates had similar antigenic characteristics to b/brisbane/60/2008. however, in the three virus ... | 2013 | 23011776 |
| extremely high myoglobin plasma concentrations producing hook effect in a critically ill patient. | a 21-year old female suffered a cardiac arrest after a one week history of viral illness later shown to be caused by influenza b. the patient required extended cardiopulmonary resuscitation and had further complications including compartment syndrome. | 2012 | 22960204 |
| first attack of kleine-levin syndrome triggered by influenza b mimicking influenza-associated encephalopathy. | six days after the onset of influenza b symptoms, a 14-year-old japanese boy presented with encephalopathy-like symptoms, somnolence, irritability, and childishness, which we first considered was an atypical type of influenza-associated encephalopathy because the infection symptoms disappeared by day 4. his encephalopathy-like symptoms gradually improved, although he had repetitive hypersomnia attacks. owing to the patient's clinical presentation and normal interleukin-6 levels in the cerebrospi ... | 2012 | 22728499 |
| advances in studies on the rupestonic acid derivatives as anti-influenza agents. | rupestonic acid (isolated from the chinese traditional medicine artemisia rupestris l.) is a sesquiterpene with multifunctional groups and possess higher activity against influenza virus b. in order to improve the biological activity of rupestonic acid, many derivatives have been synthesized and their anti-influenza activity was screened. this review describes the rupestonic acid derivatives and their anti-influenza activity studied by our researching group. | 2013 | 22625417 |
| immunogenicity and safety of a quadrivalent live attenuated influenza vaccine in children. | influenza b viruses from 2 lineages cocirculate annually. because the single b strain contained in trivalent vaccines may not match the major circulating strain, adding a second b virus could enhance protection. this study compared the safety and immunogenicity of an investigational quadrivalent ann arbor strain live attenuated influenza vaccine (q/laiv) with that of 2 trivalent vaccines (t/laiv), each containing a b strain from a different lineage. | 2012 | 22466322 |
| comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine. | evaluation of the efficacy of influenza vaccines is essential for vaccine development. this study evaluated the neutralizing and hemagglutination-inhibition antibody response in subjects receiving the 2006-07 and 2007-08 seasonal influenza vaccines. elisa-based microneutralization demonstrated a greater mean-fold increase and seroconversion rate than the hemagglutination-inhibition assay. the increase in the antibody titers against influenza h1 were higher than those against influenza h3 and inf ... | 2012 | 22433514 |
| fatal influenza b infections: time to reexamine influenza research priorities. | | 2012 | 22291194 |
| acute infantile encephalopathy predominantly affecting the frontal lobes (aief). | acute infantile encephalopathy predominantly affecting the frontal lobes (aief) is a relatively recent described entity. this article includes case reports of two patients who had bifrontal involvement during acute febrile encephalopathy. case 1 describes a 1-y-old boy who presented with hyperpyrexia and dialeptic seizures. imaging revealed significant bilateral frontal lobe involvement while serology proved presence of influenza b infection. over a period of one wk, he recovered with significan ... | 2012 | 22183762 |
| standardization of denaturing gradient gel electrophoresis (dgge) for discrimination of victoria and yamagata lineages of influenza b. | in this study, a pcr-dgge protocol was standardized in order to distinguish victoria and yamagata influenza b lineages directly from clinical samples. after routine multiplex pcr characterization, amplicons of the haemagglutinin gene bearing a 40bp-length gc clamp were generated by nested-pcr and analyzed by electrophoresis in 6% polyacrylamide gel with a 25-45% urea-formamide gradient. the results showed a perfect correlation between dgge and phylogenetic analyses for all compared samples, besi ... | 2012 | 22079619 |
| trivalent and quadrivalent mf59(®)-adjuvanted influenza vaccine in young children: a dose- and schedule-finding study. | young children are at increased risk for influenza infections and related complications. the protection offered to children by conventional trivalent inactivated influenza vaccines (tiv) is suboptimal, due to poor immunogenicity and a higher exposure to infection and complications in this age group, particularly from influenza b strains. in this dose-ranging, factorial design trial, we report the safety and immunogenicity of different combinations of adjuvanted (ativ) and non-adjuvanted trivalen ... | 2011 | 21906647 |
| protective efficacy of live-attenuated influenza vaccine (multivalent, ann arbor strain): a literature review addressing interference. | selecting the b strain for inclusion in a trivalent seasonal influenza vaccine has been difficult because two distinct influenza b lineages frequently co-circulate, prompting consideration of a quadrivalent vaccine containing two a and two b strains. because interference among wild-type influenza viruses is a well-documented phenomenon and viral replication is required to elicit protection by the licensed live-attenuated influenza vaccine (laiv; medimmune, llc, gaithersburg, md, usa), a potentia ... | 2011 | 21854309 |
| an unbiased approach for analysis of protein glycosylation and application to influenza vaccine hemagglutinin. | here a mass spectrometry-based platform for the analysis of glycoproteins is presented. glycopeptides and released glycans are analyzed, the former by quadrupole orthogonal time-of-flight liquid chromatography/mass spectrometry (qotof lc/ms) and the latter by permethylation analysis using matrix-assisted laser desorption/ionization (maldi)-tof ms. qotof lc/ms analysis reveals the stochastic distribution of glycoforms at occupied sequons, and the latter provides a semiquantitative assessment of o ... | 2011 | 21545787 |
| translational termination-reinitiation in rna viruses. | viruses utilize a number of translational control mechanisms to regulate the relative expression levels of viral proteins on polycistronic mrnas. one such mechanism, that of termination-dependent reinitiation, has been described in a number of both negative- and positive-strand rna viruses. dicistronic rnas which exhibit termination-reinitiation typically have a start codon of the 3'-orf (open reading frame) proximal to the stop codon of the upstream orf. for example, the segment 7 rna of influe ... | 2010 | 21118126 |
| in vitro selection of influenza b viruses with reduced sensitivity to neuraminidase inhibitors. | we and others have previously isolated influenza b viruses with reduced sensitivity to neuraminidase (na) inhibitors (oseltamivir and zanamivir) from patients who were never exposed to these drugs. it was unclear whether the na substitutions found in these influenza b isolates arose spontaneously or were caused by selective pressure. here, we obtained influenza b viruses with reduced na inhibitor sensitivity by in vitro selection with na inhibitors. we found that these viruses possessed the same ... | 2011 | 20636420 |
| translational termination-re-initiation in viral systems. | viruses have evolved a number of translational control mechanisms to regulate the levels of expression of viral proteins on polycistronic mrnas, including programmed ribosomal frameshifting and stop codon readthrough. more recently, another unusual mechanism has been described, that of termination-dependent re-initiation (also known as stop-start). here, the aug start codon of a 3' orf (open reading frame) is proximal to the termination codon of a uorf (upstream orf), and expression of the two o ... | 2008 | 18631147 |
| development of cold agglutinin autoimmune hemolytic anemia during treatment for pediatric acute lymphoblastic leukemia. | autoimmune hemolytic anemia (aiha) is a potentially fatal complication of many lymphoid malignancies. those most often associated with aiha include chronic lymphocytic leukemia, b-cell lymphomas, and burkitt-type acute lymphoblastic leukemia (all) and are clonal populations of mature b cells. there have been no reports of patients with b-cell precursor all who developed aiha while undergoing chemotherapy, but aiha has been reported in a few patients with all after hematopoietic stem cell transpl ... | 2005 | 16012332 |
| [autoimmune thyroiditis--an infectious disease?]. | the aim was to review existing evidence of a possible role of infectious agents in the pathogenesis of autoimmune thyroid disease. autoimmune thyroid disease is a polygenic, multifactorial disease in which genetically susceptible individuals are exposed to an environmental insult resulting in immune system activation. different viruses (influenza b, rubella, retrovirus) have been associated with thyroiditis, but no single agent appears to be causative. there is no firm evidence of infection bein ... | 2002 | 12553108 |
| [immunoglobin subclasses and determination of specific antibodies. what role in the study of children with recurrent pneumonias?]. | recurrent pyogenic infections, including pneumonia, are known to occur in children with a defective immune system. until recently, diagnosis was made by measuring major immunoglobulin isotypes and igg subclasses. recent reports show that in some cases all these measurements are normal, but that there is a defect in the production of specific protein or polysaccharide antibodies. | 2006 | 11234492 |
| reye's syndrome. | reye's syndrome is a rare disorder appearing almost always in childhood. it is characterized by acute encephalopathy and fatty degeneration of the viscera. the mortality is high and many survivors have neurologic sequelae. a viral illness, particularly varicella or influenza b, usually precedes the syndrome. it has been associated with the use of aspirin during such infections. the number of cases has declined in countries where there has been a public education campaign and aspirin products hav ... | 1997 | 9264230 |
| prevalence of antibody to current influenza virus strains in a 1992 canadian serosurvey and crude estimates of 1991-92 season a/beijing/353/89 infections. | the annual influenza serosurvey was conducted to monitor influenza activity and gauge susceptibility to currently circulating and emerging influenza viruses. | 1993 | 22346460 |
| the use of the single radial haemolysis test for assessing antibody response and protective antibody levels in an influenza b vaccine study. | single radial haemolysis (srh) and hai tests were used to determine the levels of antibody in sera obtained from 118 volunteers taking part in a study of influenza b/hong kong/73 subunit vaccine. the two tests gave similar overall results, and showed good correlation, but srh appeared to be more sensitive for the detection of low concentrations of antibody. a greater than or equal to 45% increase in srh zone area was found to be equivalent to a significant increase in antibody titre and on the b ... | 1983 | 6358228 |
| a cluster of cases of reye syndrome associated with chickenpox. | in the spring of 1980, four confirmed, and three possible cases of reye syndrome, each associated with a chickenpox prodromal illness, were identified in las cruces, nm. one patient, a 5-year-old girl, died. cases tended to occur in one section of the community, among children attending two of the 16 elementary schools. a telephone survey of parents with school-aged children (6 to 9 years old) suggested that a significantly greater attack rate of chickenpox occurred in children attending those t ... | 1982 | 7145545 |
| altered octase location in the influenza b/lee virus model for reye's syndrome. | | 1982 | 7150272 |
| surveillance of reye syndrome in the united states, 1977. | between december 1, 1976, and november 30, 1977, 454 cases of reye syndrome were reported to the centers for disease control by 43 states. analysis of data about these cases revealed that reye syndrome primarily affected white children under age 18 years, with a mean age of 7.7 years and bimodal incidence peaks in infancy and at age 6-7 years, was temporally and geographically associated with influenza b for about 75% of cases, but also occurred sporadically and not in association with influenza ... | 1981 | 7304576 |
| electronmicroscopical and immunoelectronmicroscopical examination of the lymphocytes of young and old people after influenza vaccination. | authors examined the lymphocytes of young and old individuals before, 6 days and 6 weeks after influenza vaccination. vaccination was carried out with killed influenza b/hong-kong virus. electronmicroscopic structure of the lymphocytes and membrane bound surface igg and igm were studied. membrane bound surface igg and igm were seen on the small lymphocytes and on the membrane of the medium-sized lymphocytes in young and aged individuals before and after vaccination. in both age groups intracytop ... | 1979 | 37760 |
| clinical trial with "r-75" strain live, attenuated, serum inhibitor-resistant intranasal influenza b vaccine. | the "r-75" strain live, attenuated, serum inhibitor-resistant influenza b vaccine was administered intranasally by drops in two doses 14 days apart to 21 volunteers. each vaccinee was paired with a close associate (roommate or workmate) who similarly received two doses of a placebo solution. although about 50% of both vaccine and placebo recipients complained of symptoms after dosage, the severity of symptoms was greater in vaccine recipients. fourfold serum hemagglutination-inhibiting antibody ... | 1977 | 328526 |
| cytopathological and cytochemical studies in respiratory viruses in tissue-cultured cells. i. infection with influenza a2 and influenza b viruses. | | 1975 | 814092 |
| neuraminidase- and hemagglutinin-inhibiting antibodies in serum and nasal secretions of volunteers immunized with attenuated and inactivated influenza b-eng-13-65 virus vaccines. | | 1970 | 5311581 |
| cytoplasmic inclusions and nuclear changes in cells infected with influenza-b viruses. | | 1968 | 4195915 |
| a twenty-one-year experience with antigenic variation among influenza b viruses. | | 1965 | 14265902 |
| myxoviruses associated with acute laryngotracheobronchitis in toronto, 1962-63. | between november 1962 and march 1963, myxoviruses were isolated from 95 of 224 children (40.5%), most of whom were aged less than three years, who were admitted to the hospital for sick children, toronto, with acute laryngotracheobronchitis (tracheitis or croup). viral isolates included 87 strains of parainfluenza-1, five of parainfluenza-3, and three of influenza a2. an epidemic of influenza a2 afflicted toronto during march 1963, at which time this virus was isolated from tracheitis patients.m ... | 1963 | 14098888 |
| strain specific complement-fixation differentiation of influenza b viruses isolated in tissue culture. | | 1963 | 14120357 |
| [identification of atypical strains of a virus probably belonging to influenza b isolated during the 1962 epidemic]. | | 2016 | 13978103 |
| myxovirus infections in acute laryngotracheobronchitis, toronto, 1961-62. | virological investigations were undertaken on nasopharyngeal secretions from 186 children who were admitted to the hospital for sick children, toronto, with acute laryngotracheobronchitis between december 1961 and march 1962. patients who required tracheotomy for relief of respiratory obstruction were excluded from this series. myxoviruses which were isolated from 47 patients included the following antigenic types: 29 parainfluenza-1, four parainfluenza-2, five parainfluenza-3 and nine influenza ... | 1962 | 20327304 |
| serial propagation of influenza b (lee) virus in a transmissible line of canine kidney cells. | the serial propagation of influenza b (lee) virus has been demonstrated in a transmissible line of canine kidney cells, as evidenced by the presence of cytopathic effects and hemagglutinins in each of six consecutive tissue-culture passages, and by egg infectivity titers of 10-4.3 and 10-4.1 per 0.1 ml in 3rd and 5th tissue culture fluids, respectively. | 1962 | 13901412 |
| [increased sensitivity of 1-layer tissue cultures to influenza b and se-polyoma viruses in a modified method of infection of cell suspensions]. | | 2016 | 13884917 |
| [influenza b viruses]. | | 2016 | 13915025 |
| similarity of outbreaks of asian influenza and influenza b. in a school community. | | 1961 | 19790398 |