| minipig urethra: a suitable animal model in vitro. | the study demonstrates that the minipig urethra is an appropriate animal model for in vitro experiments and therefore promising for long-term animal tests of artificial urinary sphincter systems in vivo. freshly explanted porcine and minipig urethras were connected to a fluid reservoir that simulated the bladder pressure. this bladder pressure was adjusted by changing the water level (hydrostatic pressure). specially designed aluminum sphincters loaded with a fluid-filled container were used to ... | 2012 | 23000561 |
| tissue distribution of clonidine following intraforaminal implantation of biodegradable pellets: potential alternative to epidural steroid for radiculopathy. | epidural steroid injections have shown efficacy in short-term pain relief, but often require repeated injections in order to provide continued pain relief. it has been suggested that a continuous, locally administered dose of an anti-inflammatory compound may provide sustained pain relief at doses lower than those needed with injections. | 2014 | 22996864 |
| importance of atrial surface area and refractory period in sustaining atrial fibrillation: testing the critical mass hypothesis. | the critical mass hypothesis for atrial fibrillation (af) was proposed in 1914; however, there have been few studies defining the relationship between atrial surface area and af. this study evaluated the effect of tissue area and effective refractory period (erp) on the probability of sustaining af in an in vivo model. | 2013 | 22995722 |
| derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells. | the domestic pig is an important large animal model for preclinical testing of novel cell therapies. recently, we produced pluripotency reporter pigs in which the oct4 promoter drives expression of the enhanced green fluorescent protein (egfp). here, we reprogrammed oct4-egfp fibroblasts employing the nonviral sleeping beauty transposon system to deliver the reprogramming factors oct4, sox2, klf4, and cmyc. successful reprogramming to a pluripotent state was indicated by changes in cell morpholo ... | 2013 | 22989381 |
| percutaneous transgastric traction-assisted esophageal endoscopic submucosal dissection: a randomized controlled trial in a porcine model. | endoscopic submucosal dissection (esd) is a technically difficult, hazardous, and time-consuming treatment option for superficial neoplasms of the esophagus. the aim of this pilot study was to determine the effectiveness and safety of percutaneous transgastric traction (ptt)-assisted esd, a method that overcomes the drawbacks of conventional esd, in a porcine model. | 2012 | 22989307 |
| cloning and expression of porcine colony stimulating factor-1 (csf-1) and colony stimulating factor-1 receptor (csf-1r) and analysis of the species specificity of stimulation by csf-1 and interleukin 34. | macrophage colony stimulating factor (csf-1) controls the survival, differentiation and proliferation of cells of the mononuclear phagocyte system. a second ligand for the csf-1r, interleukin 34 (il-34), has been described, but its physiological role is not yet known. the domestic pig provides an alternative to traditional rodent models for evaluating potential therapeutic applications of csf-1r agonists and antagonists. to enable such studies, we cloned and expressed active pig csf-1. to provid ... | 2012 | 22974529 |
| fate and transformation of an estrogen conjugate and its metabolites in agricultural soils. | in the environment, conjugated estrogens are nontoxic but may hydrolyze to their potent unconjugated, 'free' forms. compared to free estrogens, conjugated estrogens would be more mobile in the environment because of their higher water solubility. to identify the fate of a conjugated estrogen in natural agricultural soils, batch experiments were conducted with a (14)c labeled prototype conjugate, 17β-estradiol-3-glucuronide (e2-3g). initially, aqueous dissipation was dominated by biological hydro ... | 2012 | 22967238 |
| in vivo decontamination of the nerve agent vx using the domestic swine model. | the purpose of this in vivo study was to assess a new, putatively optimised method for mass casualty decontamination ("orchids protocol") for effectiveness in removing the chemical warfare agent vx from the skin of anaesthetised, domestic white pigs. orchids protocol consists of a 1.5-minute shower with a mild detergent (argos™) supplemented by physical removal. a standard method of wet decontamination was used for comparison. experimental animals were divided into four groups (a-d). two groups ... | 2012 | 22963275 |
| descriptive and social network analysis of pig transport data recorded by quality assured pig farms in the uk. | the aim of this study was to examine farm-to-farm pig movement connections, and the usage of hauliers and abattoirs, for farms in the united kingdom (uk), to determine the interconnectivity of the pig farm network and the implications this may have for the transmission and control of salmonella, which was chosen as an example of an important endemic disease. data were collected from three quality assurance schemes on the use of abattoirs and livestock hauliers by commercial pig farms, and the su ... | 2013 | 22959427 |
| identification of chromosomal locations associated with tail biting and being a victim of tail-biting behaviour in the domestic pig (sus scrofa domesticus). | the objective of this study was to identify loci associated with tail biting or being a victim of tail biting in norwegian crossbred pigs using a genome-wide association study with plink case-control analysis. dna was extracted from hair or blood samples collected from 98 trios of crossbred pigs located across norway. each trio came from the same pen and consisted of one pig observed to initiate tail biting, one pig which was the victim of tail biting and a control pig which was not involved in ... | 2012 | 22941514 |
| effects of local delivery of tetradecylthioacetic acid within the injured coronary vessel wall. | inflammation is involved in cell proliferation and collagen deposition causing vessel wall remodeling and restenosis after plain balloon angioplasty. local drug delivery of bioactive agents that reduce the incidence of adverse wall remodeling is of considerable interest concerning treatment strategies for coronary vessel disease and could alter the need of repeated revascularization. | 2012 | 22934973 |
| simulation of robotic radical hysterectomy using the porcine model. | this paper describes simulation of robotically-assisted radical hysterectomy using the porcine model. a technique for robotically-assisted radical hysterectomy was developed using 3 domestic pigs. an edited videoclip of the model was assessed by 3 gynecologic oncologists. the steps of the operation are described in detail and shown in a videoclip. overall the procedure simulated that done in the human, both anatomically and surgically. surgical plane development and ureterolysis appears to be ea ... | 2012 | 27638278 |
| [outbreaks of viral hepatitis e in the czech republic?]. | until recently, viral hepatitis e (vhe) has typically been an imported infection, related to travel to developing countries. a number of travel-unrelated vhe cases currently diagnosed in the czech republic. outcomes of the epidemiological investigations of two vhe outbreaks associated with the consumption of pork and pork products at pig-slaughtering feasts are presented. thirteen cases have been reported in the first outbreak and eight cases in the second outbreak. the epidemiological investiga ... | 2012 | 22880260 |
| development of a porcine (sus scofa) embryo-specific microarray: array annotation and validation. | the domestic pig is an important livestock species and there is strong interest in the factors that affect the development of viable embryos and offspring in this species. a limited understanding of the molecular mechanisms involved in early embryonic development has inhibited our ability to fully elucidate these factors. next generation deep sequencing and microarray technologies are powerful tools for delineation of molecular pathways involved in the developing embryo. | 2012 | 22863022 |
| submucosal endoscopy with mucosal resection: a hybrid endoscopic submucosal dissection in the porcine rectum and distal colon. | endoscopic submucosal dissection (esd) has appeal for en bloc resection of large flat colorectal polyps but carries appreciable risk and demands a high level of expertise and training. undermining flat and laterally spreading colorectal polyps by using submucosal endoscopy with the mucosal safety valve flap (semf) may be combined with esd to offer a hybrid technique that is easier and safer. | 2012 | 22854058 |
| vascular response and mechanical integrity of the new biodegradable polymer coated sirolimus-eluting prolim stent implanted in porcine coronary arteries. | although durable polymer coated drug-eluting stents (des) are standard care in percutaneous coronary interventions, new stent platforms employing biodegradable polymer based drug delivery are increasingly being used in clinical practice. | 2012 | 22825946 |
| myocardium at risk can be determined by ex vivo t2-weighted magnetic resonance imaging even in the presence of gadolinium: comparison to myocardial perfusion single photon emission computed tomography. | determination of the myocardium at risk (mar) and final infarct size by cardiac magnetic resonance imaging (cmr) enables calculation of salvaged myocardium in acute infarction. t2-weighted imaging is performed prior to the administration of gadolinium, since gadolinium affects t2 tissue properties. this is, however, difficult in an ex vivo model since gadolinium must be administered for determination of infarct size by cmr. we aimed to test the ability of ex vivo t2-weighted imaging to assess ma ... | 2013 | 22822155 |
| time course of endothelium-dependent and -independent coronary vasomotor response to coronary balloons and stents. comparison of plain and drug-eluting balloons and stents. | this study sought to determine the time dependency of the endothelium-dependent and -independent vascular responses after percutaneous coronary intervention (pci) with drug-eluting (deb) or plain balloons, bare-metal (bms), and drug-eluting (des) stents, or controls. | 2012 | 22814779 |
| antegrade in situ fenestration of aortic stent graft: in-vivo experiments using a pig model. | short proximal neck of an abdominal aortic aneurysm is associated with risk of treatment failure during abdominal aortic repair. important side branches, such as renal arteries, cannot be covered without serious consequences. | 2012 | 22798292 |
| ultrasound-guided percutaneous delivery of tissue-engineered endothelial cells to the adventitia of stented arteries controls the response to vascular injury in a porcine model. | high restenosis rates are a limitation of peripheral vascular interventions. previous studies have shown that surgical implantation of a tissue-engineered endothelium onto the adventitia surface of injured vessels regulates vascular repair. in the present study, we developed a particulate formulation of tissue-engineered endothelium and a method to deliver the formulation perivascular to injured blood vessels using a percutaneous, minimally invasive technique. | 2012 | 22796118 |
| nucleotide variability and linkage disequilibrium patterns in the porcine muc4 gene. | muc4 is a type of membrane anchored glycoprotein and serves as the major constituent of mucus that covers epithelial surfaces of many tissues such as trachea, colon and cervix. muc4 plays important roles in the lubrication and protection of the surface epithelium, cell proliferation and differentiation, immune response, cell adhesion and cancer development. to gain insights into the evolution of the porcine muc4 gene, we surveyed the nucleotide variability and linkage disequilibrium (ld) within ... | 2012 | 22793500 |
| vasomotor response to different endothelium-dependent vasodilators in an animal model. | incomplete re-endothelialization of stents can be revealed as paradoxical vasoconstriction with endothelium-dependent vasodilators. as no consensus exists about the best method or agent, our objective is to analyze the response to different drugs in a coronary swine model. | 2012 | 22781469 |
| microvascularization on collared peccary placenta: a microvascular cast study [corrected] in late pregnancy. | the microvascularization of the collared peccary (tayassu tajacu) placenta was studied by vascular casts and immunolocalization of α-smooth muscle actin and vimentin, to identify the three dimensional organization and vascular flow interrelation in the microvasculature between the maternal and fetal compartments of the placentae. the immunolocalization of vimentin in the vascular endothelium and in the smooth muscle cells of blood vessels showed indented capillaries along the uterine epithelium ... | 2012 | 22775252 |
| heparin does not improve graft function in uncontrolled non-heart-beating lung donation: an experimental study in pigs. | non-heart-beating donation (nhbd) has the potential to increase the number of patients treated with lung transplantation. our study investigated, in a simulated clinical situation in the uncontrolled nhbd setting, whether or not heparin administration after death affects the donor lung function. | 2013 | 22761497 |
| [pure transgastric notes laparoscopy compared to classic laparoscopy]. | notes--natural orifice transluminal endoscopic surgery--represents a new surgical approach. the operation is performed via natural openings of the body without causing any damage to the skin and the abdominal wall. at the department of surgery of the university hospital in pilsen, we have been performing notes since 2008. the first animal experiment was performed in that year by a hybrid notes technique. | 2012 | 22746085 |
| genome-wide single nucleotide polymorphism analysis reveals recent genetic introgression from domestic pigs into northwest european wild boar populations. | present-day genetic introgression from domestic pigs into european wild boar has been suggested in various studies. however, no hybrids have been identified beyond doubt mainly because available methods were unable to quantify the extent of introgression and rule out natural processes. genetic introgression from domestic pigs may have far-reaching ecological consequences by altering traits like the reproduction rate or immunology of wild boar. in this study, we demonstrate a novel approach to in ... | 2013 | 22731769 |
| effects of intravenous sulfide during resuscitated porcine hemorrhagic shock*. | controversial data are available on the effects of hydrogen sulfide during hemorrhage. because the clinical significance of hydrogen sulfide administration in rodents may not be applicable to larger species, we tested the hypothesis whether intravenous na2s (sulfide) would beneficially influence organ dysfunction during long-term, porcine hemorrhage and resuscitation. | 2012 | 22713217 |
| new swine model of infected soft tissue blast injury. | war injuries, especially blast injuries, have a high risk of infection. however, no animal models of infected war injuries have been built in large animals, which retards both the understanding and the treatment optimization of infected war injuries. | 2012 | 22710779 |
| tnf-α blockade improves early post-resuscitation survival and hemodynamics in a swine model of ischemic ventricular fibrillation. | inflammatory cytokines have been implicated in the pathophysiology of post cardiac arrest syndrome, including myocardial dysfunction and hypotension, often leading to multi-organ system dysfunction and death. we hypothesized that administration of infliximab after return of spontaneous circulation (rosc) would ameliorate hypotension and myocardial dysfunction and prolong survival. | 2013 | 22683946 |
| evaluating the feasibility of direct peroral cholangioscopy training with an endoscopic simulator. | direct peroral cholangioscopy (dpocs) was reported to present clinical potential, and creating a target-specific training program for biliary endoscopists who lack experience with dpocs is an important task. | 2012 | 22661276 |
| frequency and characterization of porcine hokovirus (phov) in domestic pigs in eastern china. | this study reports the frequency and age distribution of porcine hokovirus (phov) in domestic pigs and characterizes the strains prevalent in eastern china. a total of 242 tissues from domestic pigs were tested for phov using pcr, and six near-full-length genome sequences were used for phylogenetic analysis. the phov sequences from domestic pigs in china showed a close relationship to sequences of isolates from romania and hong kong. the results provide evidence that there are differences betwee ... | 2012 | 22653537 |
| combined intravenous treatment with ascorbic acid and desferrioxamine to reduce myocardial reperfusion injury in an experimental model resembling the clinical setting of primary pci. | during reperfusion of ischemic myocardium, oxygen-derived free radicals are produced and can cause deleterious effects, known as reperfusion injury. we aimed to determine if a combination of the antioxidant ascorbic acid and an iron-chelating agent desferrioxamine, which reduces the production of the hydroxyl radical via ferrum-catalyzed reactions, can exert a protective action against reperfusion injury. | 2013 | 22653244 |
| epizootiology of trichinellosis in pigs and wild boars in western romania, 1998-2011. | this article reports for the first time data regarding trichinellosis in sacrificed animals (domestic pigs and wild boars) inspected during the period from january 1998 to november 2011 in the largest of the romanian counties. the data were collected from the veterinary public health department of timis county. a total of 5,586,431 domestic pigs on farms, 609,325 pigs in private households, and 823 wild boars were examined during the study period. the results indicated that 681 domestic pigs (0. ... | 2012 | 22651387 |
| an acute animal model of aortic stenosis: initial attempts at leaflet modification. | percutaneous valve insertion is an emerging treatment for aortic stenosis (as). to date, no large animal model exists that replicates human calcific as; moreover, the absence of any valve pathology in currently available animal models prevents their use in any realistic assessment of percutaneous aortic valve therapy. hence, the aim of the present study was to create an acute large animal model in which human calcific as could be simulated. | 2012 | 22645851 |
| cadmium-induced changes in genomic dna-methylation status increase aneuploidy events in a pig robertsonian translocation model. | although cadmium is a well-established human carcinogen, the mechanisms by which it induces cancer are poorly understood. it is suggested that cadmium-mediated carcinogenesis may include the modulation of gene expression and signal-transduction pathways, interference with antioxidant enzymes, inhibition of dna repair and dna methylation, and induction of apoptosis. nevertheless, no predominant mechanism playing a role in metal-induced carcinogenesis has been reported. in the present study, we us ... | 2012 | 22640880 |
| novel approach to therapeutic ercp after long-limb roux-en-y gastric bypass surgery using transgastric self-expandable metal stents: experimental outcomes and first human case study (with videos). | ercp in roux-en-y gastric bypass (rygb) patients is challenging. balloon-assisted enteroscopy (bae) allows access to the excluded stomach with creation of a percutaneous endoscopic gastrostomy (peg). transgastric self-expandable metal stent (sems) placement may allow antegrade ercp in 1 session. | 2012 | 22624815 |
| early superoxide scavenging accelerates renal microvascular rarefaction and damage in the stenotic kidney. | renal artery stenosis (ras), the main cause of chronic renovascular disease (rvd), is associated with significant oxidative stress. chronic rvd induces renal injury partly by promoting renal microvascular (mv) damage and blunting mv repair in the stenotic kidney. we tested the hypothesis that superoxide anion plays a pivotal role in mv dysfunction, reduction of mv density, and progression of renal injury in the stenotic kidney. ras was induced in 14 domestic pigs and observed for 6 wk. seven ras ... | 2012 | 22622460 |
| do pharmacokinetics explain persistent restenosis inhibition by a single dose of paclitaxel? | the purpose of this study was to investigate the elimination of paclitaxel from the arterial wall after a single short administration with a coated balloon. | 2012 | 22619258 |
| reduced aluminum contamination decreases parenteral nutrition associated liver injury. | parenteral nutrition-associated cholestasis remains a significant problem, especially for the surgical neonates. aluminum is a toxic element known to contaminate parenteral nutrition. we hypothesize that parenterally administered aluminum causes liver injury similar to that seen in parenteral nutrition-associated cholestasis. | 2012 | 22595567 |
| on-farm measurement of electrical conductivity for the estimation of ammonium nitrogen concentration in pig slurry. | pig (sus scrofa domesticus) slurry (ps) is commonly applied as fertilizer to agricultural fields. knowledge of ps nitrogen content is essential for good management, but ps nitrogen content is highly variable, not only between farms but also within a farm. laboratory analysis of animal slurries is often expensive and impractical for routine farmer use. therefore, when slurry is spread on land, its fertilizer value is generally unknown, resulting in the risk of pollution. in this work, two rapid a ... | 2013 | 22565270 |
| the choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs. | the correction of hypovolemia with acellular fluids results in acute normovolemic anemia. whether the choice of the infusion fluid has an impact on the maintenance of oxygen (o₂) supply during acute normovolemic anemia has not been investigated so far. | 2012 | 22546374 |
| efficiency of spatio-temporal vaccination regimes in wildlife populations under different viral constraints. | classical swine fever (csf) is considered an endemic disease in european wild boar populations. in view of the high economic impact of the introduction of the virus into domestic pig units, huge efforts are invested in the preventive control of csf in wild boar populations. recent european community guidelines favour oral mass vaccination against csf in wild boar populations. the guidelines are explicit on the temporal structure of the vaccination protocol, but little is known about the efficacy ... | 2012 | 22530786 |
| ischemic postconditioning at the initiation of cardiopulmonary resuscitation facilitates functional cardiac and cerebral recovery after prolonged untreated ventricular fibrillation. | ischemic postconditioning (pc) with "stuttering" reintroduction of blood flow after prolonged ischemia has been shown to offer protection from ischemia reperfusion injury to the myocardium and brain. we hypothesized that four 20-s pauses during the first 3 min of standard cpr would improve post resuscitation cardiac and neurological function, in a porcine model of prolonged untreated cardiac arrest. | 2012 | 22521449 |
| cloning and expression of porcine dicer and the impact of developmental stage and culture conditions on microrna expression in porcine embryos. | microrna (mirna) is a class of small, single-stranded ribonucleic acids that regulate gene expression post-transcriptionally and are involved in somatic cell, germ cell, and embryonic development. as the enzyme responsible for producing mature mirna, dicer is crucial to mirna production. characterization of dicer and its expression at the nucleotide level, as well as the identification of mirna expression in reproductive tissues, have yet to be reported for the domestic pig (sus scrofa), a speci ... | 2012 | 22498362 |
| [the development of a type ii endoleak domesticated pig model with continuous pressure monitor]. | to develop a type ii endoleak porcine model with continuous pressure monitor by the strain-gauge pressure transducer and the patch. | 2012 | 22490355 |
| improved cerebral perfusion pressures and 24-hr neurological survival in a porcine model of cardiac arrest with active compression-decompression cardiopulmonary resuscitation and augmentation of negative intrathoracic pressure. | generation of negative intrathoracic pressure during the decompression phase of cardiopulmonary resuscitation enhances the refilling of the heart. we tested the hypothesis that when compared with closed-chest manual compressions at 80 chest compressions per min, treatment with active compression-decompression cardiopulmonary resuscitation at 80 chest compressions/min combined with augmentation of negative intrathoracic pressure would lower intracranial pressure and increase cerebral perfusion, t ... | 2012 | 22487997 |
| totally stapled gastrojejunal anastomosis using hybrid notes: single 12-mm trocar approach in a porcine model. | the aim of this study was to evaluate the feasibility of a totally stapled gastrojejunal anastomosis performed using one transabdominal 12-mm trocar and a gastroscope in a porcine model. | 2012 | 22476830 |
| δ18o values of sus scrofa blood water and bone phosphate; a marked discrepancy between domestic and wild specimens. | δ¹⁸o analyses of water in the blood of domestic and wild pigs indicated that large isotopic differences exist between domestic and wild specimens of the same species (sus scrofa) living in the same area. similar isotopic differences are found between the δ¹⁸o(po₄³⁻) values of bones from the two groups of animals. when δ¹⁸o values obtained from recent wild boar bones are introduced in the equation of the isotopic scale determined for domestic pigs, totally unreliable δ¹⁸o values of local meteoric ... | 2011 | 22468328 |
| biofunctionalization of the implant surface with different concentrations of a synthetic peptide (p-15). | this study aimed at identifying the ideal concentration of a biofunctional surface coating of dental implants with a synthetic peptide (p-15). in a previous study, p-15 was shown to enhance osseointegration parameters. | 2013 | 22458517 |
| female sex is not associated with improved rates of rosc or short term survival following prolonged porcine ventricular fibrillation. | there may be a survival benefit in female patients experiencing cardiac arrest, which could affect the interpretation of in vivo animal studies. we hypothesized that sex predicts return of spontaneous circulation (rosc) and short-term survival (surv) in porcine studies of prolonged ventricular fibrillation (vf). | 2012 | 22445866 |
| no apparent effect of an experimental narrow confinement on heart activity and cortisol in domestic pigs. | the effects of continuing spatial restraint were examined in domestic pigs. for this purpose, the animals (german landrace barrows) were housed individually in metabolic cages (12 animals) and, as controls, in single pens (six animals). in six replications with two experimental animals and one control animal, we collected saliva each morning (0730 h) for the cortisol analysis, recorded the behaviour and the heart beat for 3 h/day (0800 to 0900 h, 1100 to 1200 h, 1400 to 1500 h). each replication ... | 2011 | 22445410 |
| trapping as an alternative method of eradicating classical swine fever in a wild boar population in bulgaria. | between august and november 2009, eight cases of classical swine fever (csf) occurred in young wild boar in a 25-km2 oak forest3 km south of the river danube in the north-eastern part of bulgaria. the wild boar population within the affected area was estimated to be 156 animals, or approximately six boar per km2. to control and eradicate the disease, and in addition to vaccination and hunting, trapping was used to reduce the boar population to below two animals per km2. in total, 124 wild boar w ... | 2011 | 22435201 |
| development of a microsatellite-based method for the differentiation of european wild boar (sus scrofa scrofa) from domestic pig breeds (sus scrofa domestica) in food. | twenty microsatellites (simple sequence repeats, ssr) were used to discriminate wild boar from domestic pig and to identify mixtures of the two. reference groups of wild boar and pig samples were collected from the uk and europe for genetic assignment tests. bayesian analysis of populations software (baps) gave 100% correct assignment for blind wild boar and pig samples and correctly identified mixed samples. dna was extracted from 12 commercial food samples (11 labeled as containing wild boar) ... | 2012 | 22409233 |
| analysis of biomarkers characteristic of porcine liver injury--from biomolecular logic gates to an animal model. | a biocatalytic cascade for the analysis of the simultaneous increase in the concentration of two biomarkers characteristic of liver injury (alanine transaminase, alt, and lactate dehydrogenase, ldh) was tested on real samples acquired from an animal model (domestic pigs, sus scrofa domesticus) suffering from traumatic liver injury. a two-step reaction biocatalyzed in the presence of both enzyme-biomarkers resulted in the oxidation of nadh followed by optical absorbance measurements. a simple qua ... | 2012 | 22407106 |
| a comparison of biocompatibility and osseointegration of ceramic and titanium implants: an in vivo and in vitro study. | this study compared the biocompatibility in vitro and the osseointegration in vivo of zirconium and titanium implants regarding implant surfaces and the bone-implant contacts. the different implant surfaces and the biocompatibility of zirconium versus titanium implants were determined by vitality and cytotoxic tests in vitro. the contact of the osteoblasts to the implant surface was determined by scanning electron microscopy (sem). the in vivo study for osseointegration was performed in domestic ... | 2012 | 22406235 |
| β-adrenergic agonist infusion during extracorporeal lung perfusion: effects on glucose concentration in the perfusion fluid and on lung function. | we recently showed in a pig model of ex vivo lung perfusion (evlp) that lung edema correlates with glucose consumption. we investigated whether salbutamol, a β-adrenergic receptor agonist known to upregulate fluid transport in the lung, modulates glucose concentration in the perfusate during evlp. | 2012 | 22386450 |
| exploring channeling optimized radiofrequency energy: a review of radiofrequency history and applications in esthetic fields. | because of its high efficiency and safety, radiofrequency (rf) energy is widely used in the dermatological field for heating biological tissue in various esthetic applications, including skin tightening, skin lifting, body contouring, and cellulite reduction. this paper reviews the literature on the use of nonablative rf energy in the esthetic field and its scientific background. the purpose of this article is to describe in detail the extensive use of medical devices based on rf technology, the ... | 2012 | 22382873 |
| simulation of robotic hysterectomy utilizing the porcine model. | this article describes the simulation of robotically assisted hysterectomy utilizing the porcine model. | 2012 | 22381262 |
| the importance of craniofacial sutures in biomechanical finite element models of the domestic pig. | craniofacial sutures are a ubiquitous feature of the vertebrate skull. previous experimental work has shown that bone strain magnitudes and orientations often vary when moving from one bone to another, across a craniofacial suture. this has led to the hypothesis that craniofacial sutures act to modify the strain environment of the skull, possibly as a mode of dissipating high stresses generated during feeding or impact. this study tests the hypothesis that the introduction of craniofacial suture ... | 2012 | 22363727 |
| mri of auto-transplantation of bone marrow-derived stem-progenitor cells for potential repair of injured arteries. | this study was to validate the feasibility of using clinical 3.0t mri to monitor the migration of autotransplanted bone marrow (bm)-derived stem-progenitor cells (spc) to the injured arteries of near-human sized swine for potential cell-based arterial repair. | 2012 | 22363566 |
| disease severity declines over time after a wild boar population has been affected by classical swine fever--legend or actual epidemiological process? | classical swine fever (csf) is a severe multi-systemic disease that can affect both domestic pigs and wild boar. past outbreaks in european wild boar involved high-virulent csf virus (csfv) strains and were mostly self-limiting. in these cases, morbidity and mortality rates were high in the affected regions. in contrast, endemic infections have been observed in several european wild boar populations in recent decades. morbidity and mortality rates were much lower despite the fact that outbreaks ... | 2012 | 22361000 |
| methylation characteristics and developmental potential of guangxi bama minipig (sus scrofa domestica) cloned embryos from donor cells treated with trichostatin a and 5-aza-2'-deoxycytidine. | summary reprogramming of dna methylation in somatic cell nuclear transfer (scnt) embryos is incomplete, and aberrant dna methylation patterns are related to the inefficiency of scnt. to facilitate nuclear reprogramming, this study investigated the effect of treating guangxi bama minipig donor cells with trichostatin a (tsa), 5-aza-2'-deoxycytine (5-aza-dc), or combination of tsa and 5-aza-dc prior to nuclear transfer. analyses showed that there were no major changes in cell-cycle status among al ... | 2013 | 22355002 |
| linkage haplotype for allotypic variants of porcine iga and igg subclass genes. | six putative subclasses of expressed porcine igg have been described from gene sequences and allotypic variants for five of these have been proposed. we tested this hypothesis by studying the transcription of these 11 variants in outbred hemizygous farm pigs. since cγ subclass genes are closely linked, they are most likely inherited as a haplotype. since hemizygous pigs can only express genes encoded on one chromosome, identifying the expressed genes can indicate which allelic variants are linke ... | 2012 | 22350166 |
| non-cholinergic intervention of sarin nerve agent poisoning. | the protective effects of selected anesthetic regimens on sarin (gb) were investigated in domestic swine. at 30% oxygen, the toxicity of this agent in isoflurane anesthetized animals (ld(50)=10.1μg/kg) was similar to literature sited values in awake swine (ld(50)=11.8μg/kg) and slightly higher than that of both ketamine (ld(50)=15.6μg/kg) and propofol (ld(50)=15.3μg/kg) anesthetized swine. use of 100% oxygen in ketamine anesthetized animals resulted in three-fold protective effects compared to 3 ... | 2012 | 22343375 |
| inhibition of neointimal hyperplasia with a novel zotarolimus coated balloon catheter. | non stent based delivery of antiproliferative agents using drug coated balloon catheters may offer additional flexibility and efficacy in a broad range of applications. the lipophilic antiproliferative drug zotarolimus makes it a potential candidate for balloon delivery. the aim of the present study was to evaluate the safety and efficacy of a prototype zotarolimus coated balloon (zcb) catheter in comparison to a zotarolimus eluting stent (zes) in the porcine coronary overstretch model. | 2012 | 22293991 |
| early myocardial injury is an integral component of experimental acute liver failure - a study in two porcine models. | there is accumulating clinical evidence that acute liver failure may be regularly associated with myocardial injury. to test this hypothesis in a standardized experimental setting, we used two porcine models of alf. | 2011 | 22291759 |
| mitochondrial lineages reveal intense gene flow between iberian wild boars and south iberian pig breeds. | the phylogeography of wild boars (wb) and domestic pigs (sus scrofa) has contributed important insights into where and when domestication occurred. the geographic distribution of two core haplotypes (e1a and e1c) of the main european phylogenetic clade suggests that central europe was an early domestication centre, although the complexity of the pattern does not exclude the possibility that multiple domestication events occurred in different regions. to investigate the relationships among wb and ... | 2012 | 22221023 |
| effect of hypertransfusion on the gastrointestinal tract after cardiac arrest in a porcine model. | this study aimed to determine the potential protective effect of inducing hypertransfusion to the gastrointestinal tract following a porcine model of cardiac arrest and cardiopulmonary resuscitation (cpr) by evaluating the influence of gastrointestinal ultrastructure, atpase and serum diamine oxidase. | 2012 | 25215039 |
| performance of a novel dual-electrode bipolar radiofrequency ablation device: a chronic porcine study. | : over recent years, a variety of energy sources, including bipolar radiofrequency, have been used to replace the traditional incisions of the cox-maze procedure for the surgical treatment of atrial fibrillation (af). the purpose of this study was to evaluate the safety and efficacy of a novel dual-electrode bipolar radiofrequency ablation device synergy (atricure, inc., cincinnati, oh usa) for af in a chronic porcine model. | 2011 | 22437797 |
| identification of mitochondrial markers for genetic traceability of european wild boars and iberian and duroc pigs. | iberian pigs and wild boars are the source of highly priced meat and dry-cured products. iberian maternal origin is mandatory for labeled iberian products, making necessary the authentication of their maternal breed origin. discrimination between wild and domestic pig maternal origin may be useful to distinguish labeled wild boar meat obtained from hunting or farming. in order to detect useful polymorphisms to trace iberian, duroc and wild boar maternal lineages, we herein investigated the compl ... | 2009 | 22444897 |
| epicardial ablation on the beating heart: limited efficacy of a novel, cooled radiofrequency ablation device. | objective: to perform a minimally invasive procedure for atrial fibrillation without cardiopulmonary bypass, it is necessary to create transmural lesions on the beating heart. although bipolar radiofrequency clamps can isolate the pulmonary veins, they have difficulty in performing any other left atrial lesions, particularly those of the traditional cox-maze procedure. this study examined the performance of an internally cooled, bipolar radiofrequency device designed for such an application. met ... | 2009 | 22323899 |
| beating heart aortic valve replacement using real-time mri guidance. | : the principal limitations of percutaneous techniques to replace the aortic valve are detailed visualization and durable prostheses. we report the feasibility of using real-time magnetic resonance imaging (mri) to provide precise anatomic detail and visual feedback to implant a proven bioprosthesis. | 2007 | 22436922 |
| rational intraabdominal pressure monitoring: how to do it? | intraabdominal hypertension (iah) is increasingly appreciated by intensivists as an important cause of organ dysfunction, even at pressure levels which were previously thought to be harmless. therefore, the goal of this review is to describe the different methods commonly used in clinical practice for intraabdominal pressure (iap) measurement, the advised methodology for each measurement method, and finally to give a rational approach for iap monitoring in daily clinical practice. | 2007 | 24881697 |
| pheromonal transmission of an aversive experience in domestic pig. | the process of spontaneous learning in an automatic food dispenser by a group of domestic female pigs was studied when one of the animals of the group had an aversive experience. restraining a gilt in the dispenser without access to food resulted in later avoidance of the system by other gilts, especially when the reactions of the restrained animal had been especially violent and associated with urination. the hypothesis of a delayed transmission of an unpleasant experience was tested. the food ... | 1992 | 24254286 |
| social dominance relationships and spacing behavior of swine. | dominance ranks were determined within each of eight pens of domestic swine, susscrofa. data on spacing and orientation of subjects were obtained from 16 mm time-lapse films and 35 mm overhead photographs with the aid of a digitizer assisted fortran program, disangl 2. dominance orders among subjects were relatively linear and stable. no pattern in pen location preferences (fixed space) was found but there were relationships between dominance rank and portable spacing patterns of the subjects. d ... | 1982 | 24895965 |
| introduction of two chromosomal translocations of sus scrofa nigripes and sus scrofa scrofa into the genome of sus scrofa domestica. | hybrids between wild and domestic pigs with two types of translocations in the karyotype were studied. the translocations of type i were first detected in a population of the middle asian wild boars. type ii was identified in a populations of the central european subspecies. a large number of middle asian and central european hybrids and their f1-f3 hybrids from crosses with domestic pigs were viable. by means of differential chromosome staining, the mechanism of the formation of 'synthetic' kar ... | 1978 | 24309902 |
| chromosome translocations in the karyotypes of wild boars sus scrofa l. of the european and the asian areas of ussr. | the karyotypes of the 80 wild boars of the four subspecies, sus scrofa ussuricus heude from the far east of ussr, s. s. nigripes blanf. from kirghizia (the middle asia), s. s. attila thos. from azerbaijan, s. s. ferus from lithuania, byelorussia and central russia, and the 44 domestic pigs of the five different breeds (vietnamese black, siberian omskaja gray, kakhethian-aborigen georgian, mangalica hungarian, landrace swedish), were studied by the giemsa banding method. differential staining by ... | 1975 | 24419506 |
| [contribution to the study of cartilagines corniculata (santorini) and cuneiformis (wrisbergi) in the larynx of sus scrofa domestica]. | | 1948 | 18104325 |