| prediction of volume-responsiveness during one-lung ventilation: a comparison of static, volumetric, and dynamic parameters of cardiac preload. | the aim of this study was to evaluate the ability of static, volumetric, and dynamic parameters of cardiac preload to predict volume responsiveness during one-lung ventilation (olv). | 2013 | 23972740 |
| tissue uptake, distribution, and healing response after delivery of paclitaxel via second-generation iopromide-based balloon coating: a comparison with the first-generation technology in the iliofemoral porcine model. | this study sought to evaluate vascular drug uptake, distribution and response of second-generation paclitaxel coated balloon (pcb) (cotavance, medrad interventional, indianola, pennsylvania) and compare it with first-generation technology, containing identical excipient and drug concentration. | 2013 | 23968706 |
| assessing the risk of african swine fever introduction into the european union by wild boar. | the presence of african swine fever (asf) in the caucasus region and russian federation has increased concerns that wild boars may introduce the asf virus into the european union (eu). this study describes a semi-quantitative approach for evaluating the risk of asf introduction into the eu by wild boar movements based on the following risk estimators: the susceptible population of (1) wild boars and (2) domestic pigs in the country of origin; the outbreak density in (3) wild boars and (4) domest ... | 2015 | 23926953 |
| the effect of soil texture on the degradation of textiles associated with buried bodies. | there are many factors which affect the rate of decomposition in a grave site including; the depth of burial, climatic conditions, physical conditions of the soil (e.g. texture, ph, moisture), and method of burial (e.g. clothing, wrappings). clothing is often studied as a factor that can slow the rate of soft tissue decomposition. in contrast, the effect of soft tissue decomposition on the rate of textile degradation is usually reported as anecdotal evidence rather than being studied under contr ... | 2013 | 23890657 |
| evaluation of experimental myocardial infarction models via electromechanical mapping and magnetic resonance imaging. | the diagnostic characteristics of electromechanical mapping (emm) were evaluated in porcine myocardial infarction (mi) models with the parallel application of cardiac magnetic resonance imaging (cmri) from the aspect of different pathophysiology and localization. balloon occlusion in the left anterior descending coronary artery (lad balloon group) or coil deployment in the lad (lad coil group) or circumflex artery (cx coil group) was applied percutaneously in 16 domestic pigs. regional left vent ... | 2013 | 23888899 |
| comparative radiographic and resonance frequency analyses of the peri-implant tissue after dental implants placement using flap and flapless techniques: an experimental study on domestic pigs. | flapless implant surgery has become very important issue during recent years, mostly thanks to computerization of dentistry and software planning of dental implants placements. the aim of this study was to compare flap and flapless surgical techniques for implant placement through radiographic and radiofrequency analyses. | 2013 | 23885526 |
| dynamics of ninhydrin-reactive nitrogen and ph in gravesoil during the extended postmortem interval. | estimating the postmortem interval of skeletal remains is difficult, as few tools exist to do so. to address this problem, we conducted a field experiment to measure the chemistry of swine (sus scrofa domesticus linnaeus) gravesoil after 1 year and 3 years postmortem. carcasses were placed on the soil surface of a pasture during june in a cold (dfa) climate. significant (p < 0.05) increases in ninhydrin-reactive nitrogen, ph, total nitrogen, and nitrate in gravesoil were detected 1 year postmort ... | 2013 | 23879466 |
| a comparison between rib fracture patterns in peri- and post-mortem compressive injury in a piglet model. | forensic biomechanics is increasingly being used to explain how observed injuries occur. we studied infant rib fractures from a biomechanical and morphological perspective using a porcine model. | 2014 | 23867291 |
| occurrence of osteochondromatosis (multiple cartilaginous exostoses) in a domestic pig (sus scrofa domesticus). | osteochondromatosis is a condition in which multiple benign, cartilage-capped tumors arise from the surface of bones formed by endochondral ossification. the current report describes the presence of 4 prominent exophytic masses, measuring between 4 and 13 cm in diameter, arising from the surface of the ribs, and located within the thoracic cavity, in a 2-year-old female domestic pig (sus scrofa domesticus). histological studies revealed that masses were well-differentiated, cartilage-capped prol ... | 2013 | 23847091 |
| how immunogenetically different are domestic pigs from wild boars: a perspective from single-nucleotide polymorphisms of 19 immunity-related candidate genes. | the coexistence of wild boars and domestic pigs across eurasia makes it feasible to conduct comparative genetic or genomic analyses for addressing how genetically different a domestic species is from its wild ancestor. to test whether there are differences in patterns of genetic variability between wild and domestic pigs at immunity-related genes and to detect outlier loci putatively under selection that may underlie differences in immune responses, here we analyzed 54 single-nucleotide polymorp ... | 2013 | 23846851 |
| adenosine receptor expression in an experimental animal model of myocardial infarction with preserved left ventricular ejection fraction. | adenosine, a purine nucleoside and a "retaliatory metabolite" in ischemia, is ubiquitous in the body and increases 100-fold during ischemia. its biological actions are mediated by four adenosine receptors (ars): a(1), a(2a), a(2b) and a(3). the aim of this study was to determine possible myocardial alterations in ar expression in an experimental animal model of myocardial infarction (mi) with a preserved left ventricular (lv) ejection fraction. lv tissue was collected from sexually mature male f ... | 2014 | 23843027 |
| seasonal variation of carcass decomposition and gravesoil chemistry in a cold (dfa) climate. | it is well known that temperature significantly affects corpse decomposition. yet relatively few taphonomy studies investigate the effects of seasonality on decomposition. here, we propose the use of the köppen-geiger climate classification system and describe the decomposition of swine (sus scrofa domesticus) carcasses during the summer and winter near lincoln, nebraska, usa. decomposition was scored, and gravesoil chemistry (total carbon, total nitrogen, ninhydrin-reactive nitrogen, ammonium, ... | 2013 | 23822087 |
| histopathologic validation of optical coherence tomography findings of non-apposed side-branch struts in porcine arteries. | the presence of uncovered struts overlying side branch is considered to be a potential risk of stent thrombosis. the accuracy in detection of neointimal strut coverage at branch point by optical coherence tomography (oct) has not been validated in comparison with histology. | 2013 | 23813068 |
| high-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine. | we investigated the metabolic and functional myocardial effects of erythropoietin (epo) administered during resuscitation from cardiac arrest using an open-chest pig model of ventricular fibrillation and resuscitation by extracorporeal circulation, after having reported in rats a reversal of postresuscitation myocardial dysfunction associated with activation of mitochondrial protective pathways. ventricular fibrillation was induced in 16 male domestic pigs and left untreated for 8 minutes, after ... | 2013 | 23806450 |
| non-radiological method for three-dimensional implant position evaluation using an intraoral scan method. | this technical innovation presents a method that reproduces the position of a dental implant after insertion without the reuse of x-ray radiation. | 2014 | 23799977 |
| effects of chest compressions on cardiorespiratory function in a non-arrested porcine model. | the effects of chest compressions to hemodynamic and respiratory parameters during hands-only cardiopulmonary resuscitation (cpr) in a non-arrested patient who suddenly collapses are confusing. in this research, we investigated the effects of chest compressions in a non-arrested porcine model. | 2013 | 23786952 |
| squamous cell carcinoma in an aged german landrace sow (sus scrofa domestica). | skin tumors are rarely observed in pigs, and, in particular, only a few cases of squamous cell carcinoma have been reported. the present case report describes the occurrence of a squamous cell carcinoma located in the skin at the center of the udder of a 14-year-old german landrace sow. the tumor was spherical and 17.0 cm in diameter. the tissue of the distal pole had a cauliflowerlike appearance, was black and ulcerated with a malodorous exudation. the sow did not show any signs of reduced gene ... | 2013 | 23758043 |
| the effect of weather conditions on burnt bone fragmentation. | this research assesses how weather conditions, such as temperature and rainfall, affect the fragmentation of burnt bone. the recovery of human remains from fatal fire scenes is often hampered by the fragmentary nature of the material, and through understanding how weather factors affect this fragmentation, it may be possible to adjust recovery timelines and protocols to maximise the quantity and quality of condition of the material recovered. these data are also valuable as a baseline for expect ... | 2013 | 23756520 |
| working and reference memory of pigs (sus scrofa domesticus) in a holeboard spatial discrimination task: the influence of environmental enrichment. | interest in cognitive research in pigs is increasing, but little is known about the impact of environmental conditions on pigs' cognitive capabilities. the present study investigated the effect of environmental enrichment on cognitive performance of pigs in a holeboard spatial task, in which they had to discriminate four baited buckets out of 16. pigs (n = 32) were either housed in stimulus-poor, barren pens, or in larger pens enriched with rooting substrates. pigs were subjected to 30 holeboard ... | 2013 | 23740471 |
| digestive physiology of the pig symposium: intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways. | bile acids have historically been considered to mainly function in cholesterol homeostasis and facilitate fat digestion in the gastrointestinal tract. recent discoveries show that bile acids also function as signaling molecules that exert diverse endocrine and metabolic actions by activating g protein-coupled bile acid receptor 1 (gpbar1/g-protein-coupled bile acid receptor 1 or tgr5), a membrane g protein-coupled receptor, and farnesoid x receptor (fxr), a member of the nuclear hormone receptor ... | 2013 | 23729782 |
| experimental evaluation of pharmacokinetic profile and biological effect of a novel paclitaxel microcrystalline balloon coating in the iliofemoral territory of swine. | new paclitaxel coated balloons (pcb) developments have been proposed to maintain therapeutic levels of drug in the tissue while decreasing particle release. in this series of studies, we evaluated the pharmacokinetic profile and biological effects after paclitaxel delivery via novel microcrystalline pcb coating (mcpcb, pax®, balton) in porcine iliofemoral arteries. | 2014 | 23703720 |
| local hemodynamic disturbance accelerates early thrombosis of small-caliber expanded polytetrafluoroethylene grafts. | small-caliber expanded polytetrafluoroethylene (eptfe) grafts cannot be used widely in the clinical situation because of early thrombosis and occlusion. this unsolved and under-recognized problem warrants further investigation. | 2013 | 23703290 |
| classical swine fever. | classical swine fever is a serious and economically important transboundary disease threatening pig production globally. the infection may occur in backyard pigs, feral pig populations and domestic pigs. whereas there are proven control strategies for the latter pig population, control in backyard pigs with poor biosecurity settings or in wild boar populations of high density still poses a problem in some parts of the world. laboratory diagnostic methods, efficacious vaccines and contingency pla ... | 2013 | 23689894 |
| disposition and excretion of 14c-ahtn (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) and 14c-hhcb (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran) after intravenous administration to sprague-dawley rats and domestic pigs. | 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (ahtn ) and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran (hhcb) are polycyclic musks widely used as fragrance ingredients in consumer products. because their metabolic fate following systemic exposure is not fully characterized, disposition and excretion of (14)c-ahtn- and (14)c-hhcb-derived radioactivity were studied in sprague-dawley rats and domestic pigs following a single intravenous dose. rats admini ... | 2013 | 23685777 |
| a novel non-vascular system to treat resistant hypertension. | to evaluate in a preclinical model the utility of a monopolar electrode catheter delivering radiofrequency (rf) energy placed into the renal pelvis in order to treat resistant hypertension (rh). | 2013 | 23685301 |
| effects of cognitive enrichment on behavioural and physiological reactions of pigs. | cognitive enrichment, a special form of environmental enrichment, addresses the cognitive abilities of animals in captivity. through cognitive interaction with the environment, the animals regain a certain control over their environment, and essential resources, such as food or water, act as a reward for successful coping. it is assumed that this process has important implications for animal welfare, especially in the intensive housing systems of farm animals. this study investigates the effects ... | 2013 | 23680428 |
| us-guided application of nd:yag laser in porcine pancreatic tissue: an ex vivo study and numerical simulation. | laser ablation (la) with a neodymium-doped yttrium aluminum garnet (nd:yag) laser is a minimally invasive approach able to achieve a high rate of complete tissue necrosis. in a previous study we described the feasibility of eus-guided nd:yag pancreas la performed in vivo in a porcine model. | 2013 | 23680175 |
| crushed rephased orthogonal slice selection (cross) for simultaneous acquisition of two orthogonal proton resonance frequency temperature maps. | to evaluate a novel imaging sequence termed crushed rephased orthogonal slice selection (cross) that uses the available time in long echo time (te) gradient echo (gre) imaging-as employed for proton resonance frequency (prf) shift thermometry-to simultaneously acquire two orthogonal magnetic resonance imaging (mri) temperature maps around the target region. | 2013 | 23677906 |
| cloning changes the response to obesity of innate immune factors in blood, liver, and adipose tissues in domestic pigs. | the objective of this study was to evaluate the usefulness of cloned pigs as porcine obesity models reflecting obesity-associated changes in innate immune factor gene expression profiles. liver and adipose tissue expression of 43 innate immune genes as well as serum concentrations of six immune factors were analyzed in lean and diet-induced obese cloned domestic pigs and compared to normal domestic pigs (obese and lean). the number of genes affected by obesity was lower in cloned animals than in ... | 2013 | 23668862 |
| administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. | to compare the early postarrest inflammatory cytokine response between animals administered amiodarone (amio) and lidocaine (lido) intra-arrest during resuscitation from ventricular fibrillation (vf). domestic swine (n=32) were placed under general anesthesia and instrumented before spontaneous vf was induced by balloon occlusion of the left anterior descending coronary artery. after 7 min of vf, standard acls resuscitation was performed and animals were randomized to either bolus amio (5 mg/kg, ... | 2013 | 23659671 |
| [effect of ulinastatin on improving inflammatory response and myocardial and lung tissue injury after cardiopulmonary resuscitation in pigs]. | to evaluate the effects of ulinastatin (uti) on improving inflammatory response and myocardial and lung tissue injury after cardiopulmonary resuscitation (cpr) in porcine model. | 2013 | 23648163 |
| serological and molecular investigation of the prevalence of aujeszky's disease in feral swine (sus scrofa) in the subregions of the pantanal wetland, brazil. | the feral swine (fs) originated from the domestic pig and is present throughout the brazilian wetland plain (the pantanal). aujeszky's disease (ad) was first serologically confirmed in the state of mato grosso do sul (ms) in 2001; however, there was no viral confirmation. the aim of this study was to investigate antibodies against-suhv-1 in the sera of feral swine in the studied areas, detect suhv-1 through pcr and classify the viral genome. among the 218 animals sampled, 186 were analyzed by el ... | 2013 | 23639473 |
| primary proteasome inhibition results in cardiac dysfunction. | the proteasome prevents the intracellular accumulation of proteins and its impairment can lead to structural and functional alterations, as noted for the coronary vasculature in a previous study. utilizing the same model, this study was designed to test the hypothesis that chronic proteasome inhibition (psi) also leads to structural and functional changes of the heart. | 2013 | 23616520 |
| angiotensin receptor blockade has protective effects on the poststenotic porcine kidney. | angiotensin-converting enzyme inhibitors/angiotensin ii receptor blockers (arbs) may induce an acute decrease of glomerular filtration rate (gfr) in the stenotic kidney in renal artery stenosis, but most patients tolerate these drugs well. we hypothesized that angiotensin-converting enzyme inhibitors/arbs stabilize stenotic kidney function during prolonged treatment by conferring protective effects. we tested this in control domestic pigs and pigs with renal artery stenosis untreated or treated ... | 2013 | 23615504 |
| protective effects of ranolazine and propranolol, alone or combined, on the structural and functional alterations of cardiomyocyte mitochondria in a pig model of ischemia/reperfusion. | preventing the consequences of ischemia/reperfusion (i/r)-induced lesions in the clinic requires the administration of pharmacological agents prior to restoring coronary vascularization. the aim of this study was to evaluate the effects of ranolazine and propranolol when administered either alone or combined prior to i/r induction in a pig model. thirty domestic pigs were randomly assigned to five groups of six animals including (i) sham animals; (ii) untreated animals with 45-min ischemia and 1 ... | 2014 | 23607936 |
| activation of indoleamine 2,3-dioxygenase by lps in a porcine model. | indoleamine 2,3-dioxygenase (ido) is a rate-limiting enzyme for the degradation of tryptophan (trp) along the kynurenine (kyn) pathway, and its increased activation is associated with immunologic disorders. because the specific role of ido activation is not yet completely clear, the aim of the present study was to establish a pig model of ido activation for further research. the activation of ido in pigs was induced experimentally by lps stimulation in vivo and ex vivo. ido activation was charac ... | 2014 | 23606516 |
| hepatitis e: a puzzling double-faced disease. | viral hepatitis type e is highly endemic in many developing countries, where large water-borne epidemics caused by viral genotype 1 and - to a lesser degree - by genotype 2 cyclically occur, resulting in high morbidity and mortality, especially among pregnant women. in developed countries, the disease is usually diagnosed in travelers coming back from endemic countries, but an increasing number of sporadic locally acquired hepatitis cases caused by genotype 3 and 4 have recently been reported. t ... | 2013 | 23598800 |
| a lumen sizing workhorse guidewire for peripheral vasculature: two functions in one device. | ideally, guidewires used during peripheral vasculature (pv) interventions could serve both as a therapy delivery platform and a diagnostic tool for real-time vessel sizing (2-in-1 function). | 2014 | 23592431 |
| focused ultrasound to expel calculi from the kidney: safety and efficacy of a clinical prototype device. | focused ultrasound has the potential to expel small stones or residual stone fragments from the kidney, or move obstructing stones to a nonobstructing location. we evaluated the efficacy and safety of ultrasonic propulsion in a live porcine model. | 2013 | 23583535 |
| antegrade side branch access in branched aortic arch endografts: a porcine feasibility study. | to describe the deployment technique for a single side branch arch endograft in a porcine model and prove the concept of transseptal or transapical antegrade access for catheterization and introduction of the mating stent-graft. | 2013 | 23581770 |
| feasibility of endoscopic transumbilical thoracic sympathectomy in a porcine model. | thoracoscopic sympathectomy is an effective treatment for palmar hyperhidrosis. current methods are associated with risks of chronic neuropathic pain and a visible chest scar. we developed a novel surgical technique for the performance of sympathectomy by embryonic natural orifice transumbilical endoscopic surgery with a flexible endoscope in a porcine model. | 2013 | 23579034 |
| highly porous hydroxyapatite with and without local harvested bone in sinus floor augmentation: a histometric study in pigs. | sinus floor augmentation with autologous bone is an accepted treatment option in dental implantology. in this study, an entirely synthetic, nano-structured, hydroxyapatite-based bone substitute material (sbsm, nanobone(®); artoss, rostock, germany) was supplemented with a mixture of locally harvested bone to enhance osteogenesis. | 2014 | 23566297 |
| cranial nerve threshold for thermal injury induced by mri-guided high-intensity focused ultrasound (mrghifu): preliminary results on an optic nerve model. | future clinical applications of magnetic resonance imaging-guided high-intensity focused ultrasound (mrghifu) are moving toward the management of different intracranial pathologies. we sought to validate the production, safety, and efficacy of thermal injury to cranial nerves generated by mrghifu. in this study, five female domestic pigs underwent a standard bifrontal craniectomy under general anesthesia. treatment was then given using an mrghifu system to induce hyperthermic ablative sonication ... | 2013 | 23549530 |
| successive and conditional discrimination learning in pigs. | we studied the ability of pigs to discriminate tone cues using successive and conditional discrimination tasks. pigs (n = 8) were trained in a successive discrimination go/no-go task (experiment 1) to associate a go-cue with a reward at the end of a runway and a no-go-cue with the absence of reward. latency to reach the goal-box was recorded for each cue-type. learning of a conditional discrimination task was compared between low-birthweight (lbw, n = 5) and normal-birthweight (nbw, n = 6) pigs ... | 2013 | 23525688 |
| pig lumbar spine anatomy and imaging-guided lateral lumbar puncture: a new large animal model for intrathecal drug delivery. | intrathecal (it) administration is an important route of drug delivery, and its modelling in a large animal species is of critical value. although domestic swine is the preferred species for preclinical pharmacology, no minimally invasive method has been established to deliver agents into the it space. while a "blind" lumbar puncture (lp) can sample cerebrospinal fluid (csf), it is unreliable for drug delivery in pigs. using computed tomography (ct), we determined the underlying anatomical reaso ... | 2013 | 23518340 |
| effects of pretreatment hypothermia during resuscitated porcine hemorrhagic shock. | accidental hypothermia increases mortality and morbidity after hemorrhage, but controversial data are available on the effects of therapeutic hypothermia. therefore, we tested the hypothesis whether moderate pretreatment hypothermia would beneficially influence organ dysfunction during long-term, porcine hemorrhage and resuscitation. | 2013 | 23507715 |
| meat from wild boar (sus scrofa l.): a review. | wild boar is a species that is utilised for food and sport hunting throughout the world. recent increases in natural populations and the potential of farming wild boars have stimulated interest in this species as a meat producer. compared to domestic pigs, wild boars present a higher degree of carcass fatness and larger loin areas, more slow-twitch oxidative (i) and fast-twitch oxidative glycolytic (iia) and less fast-twitch glycolytic (iib) muscle fibres, and darker, less tender and leaner meat ... | 2013 | 23501250 |
| determination of coenzyme q10 tissue status via high-performance liquid chromatography with electrochemical detection in swine tissues (sus scrofa domestica). | swine tissues were used as surrogates for human tissues with coenzyme q10 (coq10) as the primary endogenous quinoid to establish a reliable method for the analysis of total coq10 concentration and redox status using the reduced and oxidized forms of coq9 as internal standards. specimens of frozen swine tissues were disrupted by bead milling using 2-propanol as the homogenization medium supplemented with the internal standards. after hexane extraction, coq10 was analyzed via high-performance liqu ... | 2013 | 23467099 |
| evaluation of the risk of classical swine fever (csf) spread from backyard pigs to other domestic pigs by using the spatial stochastic disease spread model be-fast: the example of bulgaria. | the study presented here is one of the very first aimed at exploring the potential spread of classical swine fever (csf) from backyard pigs to other domestic pigs. specifically, we used a spatial stochastic spread model, called be-fast, to evaluate the potential spread of csf virus (csfv) in bulgaria, which holds a large number of backyards (96% of the total number of pig farms) and is one of the very few countries for which backyard pigs and farm counts are available. the model revealed that, d ... | 2013 | 23465838 |
| in vivo and in situ evaluation of a wireless magnetoelastic sensor array for plastic biliary stent monitoring. | this paper presents the in vivo and in situ evaluation of a system that wirelessly monitors the accumulation of biliary sludge in a plastic biliary stent. the sensing element, located within the stent, is a passive array of magnetoelastic resonators that is queried by a wireless electromagnetic signal. the in vivo and in situ testing uses commercially-available plastic biliary stents, each enhanced with an array of ribbon sensors (formed from metglas™ 2826 mb). the sensor array is approximately ... | 2013 | 23460136 |
| compressive rib fracture: peri-mortem and post-mortem trauma patterns in a pig model. | despite numerous studies on high impact fractures of ribs, little is known about compressive rib injuries. we studied rib fractures from a biomechanical and morphological perspective using 15, 5th ribs of domestic pigs sus scrofa, divided into two groups, desiccated (representing post-mortem trauma) and fresh ribs with intact periosteum (representing peri-mortem trauma). ribs were axially compressed and subjected to four-point bending in an instron 3339 fitted with custom jigs. morphoscopic anal ... | 2013 | 23453778 |
| initial in vivo experience with a novel type of mr-safe pushable coils for mr-guided embolizations. | conventional detachable embolization coils are made from platinum or stainless steel and may thus be a magnetic resonance (mr) safety hazard because of resonant device heating. the objective of this experimental study was to assess the feasibility of mr-guided embolization procedures with a novel type of nonmetallic and, therefore, intrinsically mr-safe pushable coil. | 2013 | 23442773 |
| bone response to biomimetic implants delivering bmp-2 and vegf: an immunohistochemical study. | this animal study evaluated bone healing around titanium implant surfaces biomimetically coated with bone morphogenic protein-2 (bmp-2) and/or vascular endothelial growth factor (vegf) by examining bone matrix proteins and mineralisation. five different implant surfaces were established: acid-etched surface (ae), biomimetic calcium phosphate surface (cap), bmp-2 loaded cap surface, vegf loaded cap surface and dual bmp-2 + vegf loaded cap surface. the implants were inserted into calvariae of adul ... | 2013 | 23434516 |
| shen-fu injection reduces impaired myocardial β-adrenergic receptor signaling after cardiopulmonary resuscitation. | post-resuscitation myocardial dysfunction has been implicated as a major cause of fatal outcome in patients who survive initially successful cardiopulmonary resuscitation (cpr). in our previous study, we found that impaired myocardial β-adrenergic receptor (ar) signaling is a key mechanism in post-resuscitation myocardial dysfunction and shen-fu injection (sfi) can attenuate post-resuscitation myocardial dysfunction. however, whether sfi can prevent impaired post-resuscitation myocardial β-ar si ... | 2013 | 23422192 |
| hepatic and splenic stiffness augmentation assessed with mr elastography in an in vivo porcine portal hypertension model. | to investigate the influence of portal pressure on the shear stiffness of the liver and spleen in a well-controlled in vivo porcine model with magnetic resonance elastography (mre). a significant correlation between portal pressure and tissue stiffness could be used to noninvasively assess increased portal venous pressure (portal hypertension), which is a frequent clinical condition caused by cirrhosis of the liver and is responsible for the development of many lethal complications. | 2013 | 23418135 |
| the foetal pig pineal gland is richly innervated by nerve fibres containing catecholamine-synthesizing enzymes, neuropeptide y (npy) and c-terminal flanking peptide of npy, but it does not secrete melatonin. | innervation of the mammalian pineal gland during prenatal development is poorly recognized. therefore, immunofluorescence studies of the pineals of 70- and 90-day-old foetuses of the domestic pig were performed using antibodies against tyrosine hydroxylase (th), dopamine-β-hydroxylase (dβh), neuropeptide y (npy) and c-terminal flanking peptide of npy (cpon). the investigated glands were supplied by numerous nerve fibres containing th and dβh. the density of these fibres was higher in the distal ... | 2013 | 23408385 |
| early detection of acute mesenteric ischemia using diffusion-weighted 3.0-t magnetic resonance imaging in a porcine model. | the aim of this study was to investigate if 3.0-t diffusion-weighted magnetic resonance imaging (mri) can be used for early detection of acute occlusive and nonocclusive mesenteric ischemia. | 2013 | 23385397 |
| determination of organ-specific anemia tolerance. | utilization of anemia tolerance reduces the need for and risks of perioperative transfusion. recent publications indicate that the critical limit for oxygen supply might not be the same for each organ system. therefore, we investigated the effects of acute dilutional anemia on heart, brain, kidneys, liver, small intestine, and skeletal muscle to quantify organ-specific tolerance of different levels of acute anemic hypoxia. we hypothesized that, in some organs, tissue hypoxia occurs before the cr ... | 2013 | 23385097 |
| ischemic post-conditioning and vasodilator therapy during standard cardiopulmonary resuscitation to reduce cardiac and brain injury after prolonged untreated ventricular fibrillation. | we investigated the effects of ischemic postconditioning (ipc) with and without cardioprotective vasodilatory therapy (cvt) at the initiation of cardiopulmonary resuscitation (cpr) on cardio-cerebral function and 48-h survival. | 2013 | 23376583 |
| hysteresis in di independent mechanisms in threshold for transition between 1:1 and 2:2 rhythms in pigs. | previous studies have shown hysteresis in transition from 1:1 to 2:2 rhythms in action potential durations (apd) during decreasing and increasing cycle length pacing. as cycle lengths were constant, when alternans of apd occurred, so did of preceding diastolic intervals (dis), which engaged the restitution mechanism, i.e. dependence of apd on preceding di, making it impossible to determine whether the hysteresis originates from the di independent or dependent mechanism. by using pacing with expl ... | 2012 | 23365980 |
| computed tomography-based diagnosis of diffuse compensatory enlargement of coronary arteries using scaling power laws. | glagov's positive remodelling in the early stages of coronary atherosclerosis often results in plaque rupture and acute events. because positive remodelling is generally diffused along the epicardial coronary arterial tree, it is difficult to diagnose non-invasively. hence, the objective of the study is to assess the use of scaling power law for the diagnosis of positive remodelling of coronary arteries based on computed tomography (ct) images. epicardial coronary arterial trees were reconstruct ... | 2013 | 23365197 |
| fluid resuscitation guided by sublingual partial pressure of carbon dioxide during hemorrhagic shock in a porcine model. | to avoid aggressive fluid resuscitation during hemorrhagic shock, fluid resuscitation is best guided by a specific measurement of tissue perfusion. we investigated whether fluid resuscitation guided by sublingual pco2 would reduce the amount of resuscitation fluid without compromising the outcomes of hemorrhagic shock. ten male domestic pigs weighing between 34 and 37 kg were used. forty-five percent of estimated blood volume was removed during an interval of 1 h. the animals were then randomize ... | 2013 | 23364438 |
| a comparison of etanercept vs. infliximab for the treatment of post-arrest myocardial dysfunction in a swine model of ventricular fibrillation. | to compare the effects of two tnf-α antagonists, etanercept and infliximab, on post-cardiac arrest hemodynamics and global left ventricular function (lv) in a swine model following ventricular fibrillation (vf). | 2013 | 23313857 |
| [model of genetic control of the number and location of nipples in domestic pig]. | in domestic pig, the number and location of nipples is considered a single quantitative trait, which has a complex spatial structure that includes bilaterality and a linear sequence of repetitive elements. according to this hypothesis, six inadherent biallelic loci are sufficient for a variety of traits observed in domestic pig populations. verification of representative samplings from five domestic pig populations of different origin (about 20 000 individuals) confirmed the theses of the hypoth ... | 2012 | 23297487 |
| septic shock non-thyroidal illness syndrome causes hypothyroidism and conditions for reduced sensitivity to thyroid hormone. | non-thyroidal illness syndrome (ntis) is part of the neuroendocrine response to stress, but the significance of this syndrome remains uncertain. the aim of this study was to investigate the effect of lipopolysaccharide (lps)-induced ntis on thyroid hormone (th) levels and th molecular targets, as well as the relationship between septic shock nuclear factor kappa-light-chain-enhancer of activated b cells (nf-kb) activation and th receptor β (thrb) gene expression at a multi-tissue level in a pig ... | 2013 | 23296981 |
| apoptotic transcriptional profile remains activated in late remodeled left ventricle after myocardial infarction in swine infarcted hearts with preserved ejection fraction. | apoptosis is involved in both acute and chronic loss of cardiomyocytes after myocardial infarction (mi). to date, the pathophysiological significance of an apoptotic transcriptional profile activated in the post-ischemic remodeled myocardium, in the absence of hemodynamic factors secondary to left ventricular (lv) dysfunction, still remains to be determined. the mrna expression of pro- and anti-apoptotic factors was determined in a swine model of non-reperfused mi with preserved lv ejection frac ... | 2013 | 23295943 |
| the impact of early goal-directed fluid management on survival in an experimental model of severe acute pancreatitis. | severe acute pancreatitis (sap) remains a life-threatening disease with classic etiology of systemic inflammatory response and mortality between 30 and 50 %. the aim of the present study is to compare two different treatment strategies of goal-directed hemodynamic management and evaluate their impact on survival, microcirculation, tissue oxygenation, and histopathologic damage in acute pancreatitis in a prospective animal study. | 2013 | 23287870 |
| best practices for performing experimental surgery in swine. | the authors have extensive experience in surgery, anesthesia, and perioperative care in both miniature and domestic swine in the research setting. this manuscript describes the techniques that have been developed over the last four decades while developing porcine surgical models and their use in translational research. swine are conditioned and socialized during a seven-day period prior to entering into a survival surgical protocol. housing is designed to be nonstressful and accommodate the nee ... | 2013 | 23281597 |
| a new approach for rapidly assessing the risk of aujeszky's disease reintroduction into a disease-free spanish territory by analysing the movement of live pigs and potential contacts with wild boar. | aujeszky's disease (ad) causes significant economic losses in the spanish pig sector due to import trade restrictions imposed by disease-free countries. most regions of spain have achieved 'low ad prevalence' status as a result of an intensive national ad eradication programme involving vaccination and other measures. however, to achieve ad-free status that would eliminate trade restrictions, vaccination must be stopped. for this final stage of eradication, up to date and reliable estimates of t ... | 2014 | 23279743 |
| sem and stereomicroscopic analysis of cut marks in fresh and burned bone. | this study documents the prevalence of cut mark characteristics in fresh and burned domestic pig ribs. stab wounds from single edge serrated and smooth-edged knives were inflicted in the vertebral and sternal regions of each fresh rib. each rack of ribs was then divided into vertebral and sternal units. vertebral units were defleshed and their associated cut marks were examined using a stereomicroscope. sternal units were burned in an outdoor fire pit and examined with the addition of a scanning ... | 2013 | 23278902 |
| transdermal delivery of adipocyte-derived stem cells using a fractional ablative laser. | chronic wound healing problems can pose a significant clinical challenge. transdermal delivery of adipose-derived stem cells (adsc) may be a possible solution to healing these recalcitrant, debilitating wounds. pretreatment of the skin with a fractionated laser has already been shown to assist transdermal drug delivery both in vitro and in vivo and may be an ideal approach to facilitating delivery of adsc to the target tissue. | 2013 | 23277622 |
| epidemiological overview of african swine fever in uganda (2001-2012). | african swine fever (asf) is a contagious viral disease, which can cause up to 100% mortality among domestic pigs. in uganda there is paucity of information on the epidemiology of the disease, hence a study was carried out to elucidate the patterns of asf outbreaks. spatial and temporal analyses were performed with data collected monthly by the district veterinary officers (dvos) and sent to the central administration at maaif from 2001 to 2012. additionally, risk factors and the associated char ... | 2013 | 26464916 |
| 1ppab5. acoustic radiation force to reposition kidney stones. | our group has introduced transcutaneous ultrasound to move kidney stones in order to expel small stones or relocate an obstructing stone to a nonobstructing location. human stones and metalized beads (2-8 mm) were implanted ureteroscopically in kidneys of eight domestic swine. ultrasonic propulsion was performed using a diagnostic imaging transducer and a verasonics ultrasound platform. stone propulsion was visualized using fluoroscopy, ultrasound, and the ureteroscope. successful stone movement ... | 2017 | 26207161 |
| effect of rescue breathing during cardiopulmonary resuscitation on lung function after restoration of spontaneous circulation in a porcine model of prolonged cardiac arrest. | the destruction of the pulmonary structure after cardiopulmonary resuscitation may lead to lung function breakdown. the aim of this study was to investigate lung function after cardiopulmonary resuscitation and the influence of rescue breathing on lung function. | 2013 | 23269128 |
| nano-crystalline diamond-coated titanium dental implants - a histomorphometric study in adult domestic pigs. | promising biomaterial characteristics of diamond-coatings in biomedicine have been described in the literature. however, there is a lack of knowledge about implant osseointegration of this surface modification compared to the currently used sandblasted acid-etched ti-al6-v4 implants. the aim of this study was to investigate the osseointegration of microwave plasma-chemical-vapour deposition (mwp-cvd) diamond-coated ti-al6-v4 dental implants after healing periods of 2 and 5 months. twenty-four mw ... | 2013 | 23266005 |
| hypothermia ameliorates gastrointestinal ischemic injury sustained in a porcine cardiac arrest model. | during cardiac arrest, the gastrointestinal tract is sensitive to ischemia. protection of the gastrointestinal tract is a critical factor in determining prognosis following cardiopulmonary resuscitation (cpr). this study seeks to determine the extent of gastrointestinal tract injury and the potential protective effect of inducing hypothermia following a porcine cardiac arrest model and cpr. | 2012 | 23253710 |
| domestication does not narrow mhc diversity in sus scrofa. | the major histocompatibility complex (mhc) is a multigene family of outstanding polymorphism. mhc molecules bind antigenic peptides in the peptide-binding region (pbr) that consists of five binding pockets (p). in this study, we compared the genetic diversity of domestic pigs to that of the modern representatives of their wild ancestors, the wild boar, in two mhc loci, the oligomorphic dqa and the polymorphic drb1. mhc nucleotide polymorphism was compared with the actual functional polymorphism ... | 2013 | 23239371 |
| three-dimensional regional strain analysis in porcine myocardial infarction: a 3t magnetic resonance tagging study. | previous studies of mechanical strain anomalies in myocardial infarction (mi) have been largely limited to analysis of one-dimensional (1d) and two-dimensional (2d) strain parameters. advances in cardiovascular magnetic resonance (cmr) methods now permit a complete three-dimensional (3d) interrogation of myocardial regional strain. the aim of this study was to investigate the incremental value of cmr-based 3d strain and to test the hypothesis that 3d strain is superior to 1d or 2d strain analysi ... | 2012 | 23237210 |
| genetic characterisation of a porcine bocavirus detected in domestic pigs in uganda. | porcine bocaviruses (pobovs) are small linear ssdna viruses belonging to the genus bocavirus in the family parvoviridae. the genome encodes four proteins-the non-structural protein 1 (ns1), the np1 protein (unknown function) and the two structural proteins vp1 and vp2. in recent years, a number of different highly divergent pobov species have been discovered. pobovs have been shown to be present in pig populations in europe, asia and in the united states of america. in this study, we present the ... | 2013 | 23225112 |
| indocyanine-green-loaded microballoons for biliary imaging in cholecystectomy. | we encapsulate indocyanine green (icg) in poly[(d,l-lactide-co-glycolide)-co-peg] diblock (plga-peg) microballoons for real-time fluorescence and hyperspectral imaging of biliary anatomy. icg-loaded microballoons show superior fluorescence characteristics and slower degradation in comparison with pure icg. the use of icg-loaded microballoons in biliary imaging is demonstrated in both biliary-simulating phantoms and an ex vivo tissue model. the biliary-simulating phantoms are prepared by embeddin ... | 2012 | 23214186 |
| carbon dioxide-contrasted computed tomography angiography: high pitch protocols and adapted injection parameters improve imaging quality. | to systematically investigate the impact of image acquisition and contrast injection parameters for co2-enhanced ct angiography (cta) of the aorto-iliac and peripheral arteries in a pig model using commercially available equipment. the aim was to establish an imaging protocol that is ready for use in human subjects. | 2013 | 23196833 |
| similar growth plate morphology in stapling and tension band plating hemiepiphysiodesis: a porcine experimental histomorphometric study. | the tension band plating technique for hemiepiphysiodesis is new and advocated because it is believed to reduce the risk of premature closure of the growth plate compared to stapling. the benefit of the tension band plating technique has not yet been proven in experimental or randomized clinical studies. ten weeks old domestic pigs in two randomized, paired studies were used. right proximal tibia was randomized to medial epiphysiodesis by either stapling or tension band plating. left side receiv ... | 2013 | 23192490 |
| pig domestication and human-mediated dispersal in western eurasia revealed through ancient dna and geometric morphometrics. | zooarcheological evidence suggests that pigs were domesticated in southwest asia ~8,500 bc. they then spread across the middle and near east and westward into europe alongside early agriculturalists. european pigs were either domesticated independently or more likely appeared so as a result of admixture between introduced pigs and european wild boar. as a result, european wild boar mtdna lineages replaced near eastern/anatolian mtdna signatures in europe and subsequently replaced indigenous dome ... | 2013 | 23180578 |
| [pharmacological influencing of abdominal aortic aneurysm model - animal experimental study, primary results]. | the aim of our work was to influence growth and histological changes in the wall of an experimentally induced aneurysm of the abdominal aorta in a large laboratory animal (domestic pig) by administering atorvastatin (3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor). | 2012 | 23152990 |
| pathogenesis of african swine fever in domestic pigs and european wild boar. | african swine fever (asf) is among the most important viral diseases that can affect domestic and feral pigs. both clinical signs and pathomorphological changes vary considerably depending on strain virulence and host factors. acute infections with highly virulent virus strains lead to a clinical course that resembles a viral haemorrhagic fever that is characterized by pronounced depletion of lymphoid tissues, apoptosis of lymphocyte subsets, and impairment of haemostasis and immune functions. i ... | 2013 | 23137735 |
| biological heart rate reduction through genetic suppression of gα(s) protein in the sinoatrial node. | elevated heart rate represents an independent risk factor for cardiovascular outcome in patients with heart disease. in the sinoatrial node, rate increase is mediated by β(1) adrenoceptor mediated activation of the gα(s) pathway. we hypothesized that genetic inactivation of the stimulatory gα(s) protein in the sinoatrial node would provide sinus rate control and would prevent inappropriate heart rate acceleration during β-adrenergic activation. | 2012 | 23130123 |
| propolis modulates vitronectin, laminin, and heparan sulfate/heparin expression during experimental burn healing. | this study was aimed at assessing the dynamics of vitronectin (vn), laminin (ln), and heparan sulfate/heparin (hs/hp) content changes during experimental burn healing. | 2012 | 23125086 |
| vagal projections to the pylorus in the domestic pig (sus scrofa domestica). | the goal of the present study was to examine the precise localization of the brainstem motor and primary sensory (nodose ganglion) vagal perikarya supplying the pylorus in the domestic pig. using the fast blue retrograde tracing technique it has been established that all the vagal motor neurons projecting to the pylorus (about 337 ± 59 cells per animal) were localized bilaterally in the dorsal motor nucleus of the vagus nerve (dmx, 171 - left; 167 - right) and all other regions of the porcine br ... | 2012 | 23103024 |
| [manual annotation of the pig whole genomic sequence using otterlace software]. | in november 2009, scientists from the us, uk, and other countries announced the complete genome sequence draft of the domestic pig. with the release of improved versions of the pig genome assembly and the increase of correctly assembled sequenced fragments over the past two years, it is particularly urgent to have the pig genes annotated at whole-genome level. this article is aimed at introducing an excellent manual annotation tool, otterlace software, developed by sanger institute. we used cfl1 ... | 2012 | 23099791 |
| [detecting selection signatures on x chromosome in pig through high density snps]. | in the process of domestic pig breeding, many important economic traits were subject to strong artificial se-lection pressure. with the availability of high density single nucleotide polymorphism (snp) markers in farm animals, selection occurring in those traits could be traced by detecting selection signatures on genome, and the genes experiencing selection can also be further mined based on selection signatures. due to the special characteristic of x chromosome, many approaches of genetic anal ... | 2012 | 23099781 |
| the effects of a newly developed miniaturized mechanical chest compressor on outcomes of cardiopulmonary resuscitation in a porcine model*. | when the duration of cardiac arrest is prolonged, reperfusion of the vital organs by effective chest compression is the most important intervention for successful resuscitation. we investigated the effects of a newly developed miniaturized chest compressor on the outcomes of cardiopulmonary resuscitation. | 2012 | 23080437 |
| endoscopic full-thickness biopsy of the gastric wall with defect closure by using an endoscopic suturing device: survival porcine study. | the pathogenesis of several common gastric motility diseases and functional gi disorders remains essentially unexplained. gastric wall biopsies that include the muscularis propria to evaluate the enteric nervous system, interstitial cells of cajal, and immune cells can provide important insights for our understanding of the etiology of these disorders. | 2012 | 23078926 |
| evaluation of efficacy and dose response of different paclitaxel-coated balloon formulations in a novel swine model of iliofemoral in-stent restenosis. | the authors aimed to validate a novel iliofemoral in-stent restenosis (isr) model for the efficacy evaluation of paclitaxel-coated balloons (pcb) using the familial hypercholesterolemic swine (fhs). | 2012 | 23078739 |
| relationship between intrathoracic pressure and hemodynamics during cardiopulmonary resuscitation in a porcine model of prolonged cardiac arrest. | the influences of intrathoracic pressure (itp) to hemodynamic and respiratory parameters during cardiopulmonary resuscitation (cpr) are confusing. in this research, we investigated the phasic changes of itp during cpr and reveal the relationships among the hemodynamics, respiratory parameters, and itp. | 2012 | 23075711 |
| mri quantification of left ventricular function in microinfarct versus large infarct in swine model. | to quantify, using mri, the acute impacts of defined volume and sizes of coronary microemboli on myocardial viability and left ventricular (lv) function and to use lad occlusion/reperfusion, as a reference. a total of 28 farm pigs were used in this study. eight animals were used as controls. successful coronary interventions were performed under x-ray fluoroscopy in 16 pigs to induce microinfarct (delivery of 16 mm(3) of 40-120 μm) and large infarct (90 min lad occlusion/reperfusion). on day 3, ... | 2013 | 23065097 |
| evaluation of domestic and yucatan swine nasal sinus anatomy as models for future sinonasal research of medications delivered by standard instruments used in functional endoscopic sinus surgery. | there is a need to find an animal model to study new medications to improve mucosal wound healing after functional endoscopic sinus surgery (fess). current literature suggests swine as a potential candidate. the lack of information correlating swine computer tomography (ct) and endoscopic sinonasal anatomy prompted us to investigate them in the domestic and yucatan swine to determine their feasibility as models to test new medications and drug-embedded stents applied using fess techniques. | 2013 | 23038683 |
| adjuvants to prolong the local anesthetic effects of coated microneedle products. | the objective of this study was to identify an adjuvant for anesthetics coated on microneedles to provide rapid onset and prolonged analgesic action with minimal skin tissue reaction. aqueous lidocaine or prilocaine formulations with or without clonidine or the related analogs, guanfacine and apraclonidine, were dip-coated onto polymeric microneedles. the amount of lidocaine or prilocaine coated onto the microneedles was assessed by high performance liquid chromatography (hplc). delivery efficie ... | 2012 | 23022295 |
| from bench to bedside: initial experience with the primus drug-coated balloon catheter. | drug-coated balloon (dcb) technology has emerged as a promising therapy particularly in the treatment of coronary in-stent restenosis. although a variety of devices are available for clinical use, clinical outcomes have been variable and scope for significant improvement exists. | 2012 | 23018430 |
| evaluation of factors important in modeling plasma concentrations of tetracycline hydrochloride administered in water in swine. | to model the plasma tetracycline concentrations in swine (sus scrofa domestica) treated with medication administered in water and determine the factors that contribute to the most accurate predictions of measured plasma drug concentrations. | 2012 | 23013192 |
| [sequence of depolarization of atrial myocardium of the pig (sus scrofa domesticus)]. | by the method of multichannel synchronous cardioelectropotography, sequence of depolarization of intramural atrial layers was studied in representatives of ungulate animals--pigs. in the pig atrial myocardium there is revealed a complex picture of spreading of activation fronts, connected with non-uniform anatomical structure and subendocardial (intramural) disposition of area of initial activation. the general character of sequence of depolarization of the pig atrial myocardium is comparable wi ... | 2012 | 23013027 |