| in-vitro activity of sitafloxacin (du-6859a), either singly or in combination with rifampin analogs, against mycobacterium leprae. | the in-vitro antibacterial activity of sitafloxacin (du-6859a) against mycobacterium leprae was evaluated and compared with those of ofloxacin, levofloxacin, and ciprofloxacin. two biochemical indicators (intracellular atp and uptake of [(3)h]-thymidine) were used to measure the in-vitro growth of m. leprae in dhople-hanks (dh) medium. sitafloxacin was found to be more potent than the other three commonly used fluoroquinolones, with the minimum inhibitory concentration (mic) against m. leprae be ... | 2003 | 12673400 |
| fontilles faces the future of leprosy. | | 2003 | 12679256 |
| activation and regulation of toll-like receptors 2 and 1 in human leprosy. | the expression and activation of toll-like receptors (tlrs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted toward mycobacterium leprae. tlr2-tlr1 heterodimers mediated cell activation by killed m. leprae, indicating the presence of triacylated lipoproteins. a genome-wide scan of m. leprae detected 31 putative lipoproteins. synthetic lipopeptides representing the 19-kd and 33-kd lipoproteins activated both monocy ... | 2003 | 12692544 |
| localized lepromatous leprosy presenting as a painful nodule in a muscle. | lepromatous leprosy is a generalized disease usually presenting with numerous macules, papules, nodules or plaques involving wide areas of the skin. it is generally believed that in india lepromatous leprosy often originates from the borderline spectrum (jha et al, 1991). localized lepromatous or borderline lepromatous disease is a rare variant of multibacillary leprosy (yoder et al, 1985; jha et al, 1991; pfaltzgraff & ramu, 1994; vijaikumar et al, 2001). this variant usually presents as a sing ... | 2002 | 12708703 |
| unusual localization of lesions in lepromatous leprosy. | | 2002 | 12708705 |
| reactions in borderline leprosy. | this is a retrospective study of 276 patients consisting of 157 active and 119 reactive patients of borderline leprosy. they were followed up for 10 years after sulphone monotherapy. the presenting symptoms were carefully examined from the records and systematically presented. frequency of reactions was least in bt cases and most in bl cases. risk factors of reaction appear to be the type of leprosy, multiplicity of lesions, high bi and, possibly, psychological stress. biopsy of skin lesions was ... | 2002 | 12708730 |
| incidence of leprosy in school-children and their family members in berhampur. | a school survey, followed by a contact survey, was carried out in berhampur, a city in southern orissa. in a study of 8,870 school-children, leprosy was detected in 15, giving a prevalence rate of 16.91 per 10,000 with a male:female ratio of 8:7. of these, 14 (93.99%) had paucibacillary leprosy. more cases [11 (73.33%)] were seen in the age-group of 10-15 years. exposed parts, such as lower limbs, upper limbs and head and neck in that order, were the sites of predilection, accounting for 85.71% ... | 2002 | 12708732 |
| single dose rom therapy in goa. | | 2002 | 12708738 |
| induction of apoptosis in monocytes by mycobacterium leprae in vitro: a possible role for tumour necrosis factor-alpha. | a diverse range of infectious organisms, including mycobacteria, have been reported to induce cell death in vivo and in vitro. although morphological features of apoptosis have been identified in leprosy lesions, it has not yet been determined whether mycobacterium leprae modulates programmed cell death. for that purpose, peripheral blood mononuclear cells obtained from leprosy patients were stimulated with different concentrations of this pathogen. following analysis by flow cytometry on 7aad/c ... | 2003 | 12709029 |
| role of fluorescent microscopy in detecting mycobacterium leprae in tissue sections. | we compared the sensitivity of the fluorescent method with that of he modified fite-faraco method in the detection of mycobacterium leprae in tissue sections. fifty-six skin biopsies were obtained from patients having leprosy, particularly the paucibacillary type. minor alterations were made in the deparaffinization and staining technique, as compared with kuper and may's method, to obtain optimum fluorescence. of 56 biopsies studied, 39 showed organisms by the fluorescent method and only 25 sho ... | 2003 | 12715331 |
| [comparative genomics of mycobacterium tuberculosis and m. leprae]. | | 2003 | 12718060 |
| [leprosy]. | | 2003 | 12722275 |
| detection of gene mutations related with drug resistance in mycobacterium leprae from leprosy patients using touch-down (td) pcr. | the lack of methods to identify mycobacterium leprae with the resistance against multi-drugs quickly and specifically has hindered effective chemotherapy against m. leprae infection. to screen m. leprae with resistance against multi-drugs, the touch-down (td)-pcr has been used in this study. sequences of the folp, rpoa, b, and gyra, b genes were analyzed for isolates of m. leprae from leprosy patients in korea. we amplified designated region of several genes in m. leprae involved in drug resista ... | 2003 | 12727362 |
| simple and fast lateral flow test for classification of leprosy patients and identification of contacts with high risk of developing leprosy. | the interruption of leprosy transmission is one of the main challenges for leprosy control programs since no consistent evidence exists that transmission has been reduced after the introduction of multidrug therapy. sources of infection are primarily people with high loads of bacteria with or without clinical signs of leprosy. the availability of a simple test system for the detection of antibodies to phenolic glycolipid-i (pgl-i) of mycobacterium leprae to identify these individuals may be impo ... | 2003 | 12734239 |
| atomic force microscopy as a tool for biomedical and biotechnological studies. | this work presents different applications in progress with the aid of the atomic force microscopy (afm) technique for biomedical and biotechnological applications, comprising both the acquisition of three-dimensional images and spectroscopic force measurements, in the following systems: first, low-density lipoprotein (ldl)-glycosaminoglycans; second, lectins-polysaccharides; third, mycobacterium leprae cellular wall and vesicular stomatites virus (vsv) with fibronectin laminin, and lipidic membr ... | 2003 | 12752206 |
| the combination of plasmid interleukin-12 with a single dna vaccine is more effective than mycobacterium bovis (bacille calmette-guèrin) in protecting against systemic mycobacterim avium infection. | sub-unit vaccines utilizing purified mycobacterial proteins or dna vaccines induce partial protection against mycobacterial infections. for example, immunization with dna vaccines expressing the gene for the immunodominant 35000 mw protein, common to mycobacterium avium and mycobacterium leprae but absent from the mycobacterium tuberculosis complex, conferred significant protection against infection with either virulent m. avium or m. leprae in mice. however, the level of protection was equivale ... | 2003 | 12757627 |
| dosage and site of entry influence growth and dissemination of mycobacterium leprae in t900r mice. | the role of dosage of mycobacterium leprae and the environment of the inoculated site, in producing leprosy lesions in immunologically-suppressed, highly-susceptible t900r mice, was investigated. various doses of m. leprae, i.e., 10(7), 10(6), 10(5), 10(4), were inoculated into both flanks and footpads of two different groups of mice. the sites of inoculation were biopsied for histopathological examination and for m. leprae counts at the end of 6, 8 and 12 months. m. leprae multiplied at the inf ... | 2002 | 12768925 |
| profiles of the mrna expression by macrophages infected with mycobacterium leprae and mycobacterium avium complex. | in the present study, we examined profiles of the interaction of mycobacterium leprae and mycobacterium avium complex (mac) with murine peritoneal macrophages (m phi s) in terms of up-regulation of m phi expression of proinflammatory and immunosuppressing cytolines (cks) after infection. first, the reverse transcription polymerase chain reaction (rt-pcr) assay revealed that both mac and m. leprae infections up-regulated m phi mrna expression il-12, tnf-alpha, il-10, and transformating growth fac ... | 2002 | 12768926 |
| ap-1 is present in nuclear extracts of lymphocytes from lepromatous leprosy patients. | | 2002 | 12768929 |
| geographically specific infections and arthritis, including rheumatic syndromes associated with certain fungi and parasites, brucella species and mycobacterium leprae. | this overview is designed to introduce the reader to the broad spectrum of rheumatic syndromes associated with certain fungal and parasitic diseases, brucellosis and leprosy. musculoskeletal disorders caused by fungi are uncommon and difficult to diagnose, particularly in the early stages. deep fungal infections involve-in order of frequency-bone, soft tissues and joints. rare but well-defined rheumatic syndromes occur in a variety of parasitic diseases. brucellosis remains a major challenge to ... | 2003 | 12787526 |
| systemic dissemination in tuberculosis and leprosy: do mycobacterial adhesins play a role? | more than one century after the discovery of their etiological agents, tuberculosis and leprosy remain as major health threats for humans, and the molecular mechanisms that lead to the development of both diseases are poorly understood. the elucidation of these mechanisms, and especially those allowing for the mycobacteria to systemically disseminate, should facilitate the development of new prophylactic and/or therapeutic strategies. this review is focused on the routes that mycobacterium tuber ... | 2003 | 12787744 |
| the complete genome sequence of mycobacterium bovis. | mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and man, with worldwide annual losses to agriculture of $3 billion. the human burden of tuberculosis caused by the bovine tubercle bacillus is still largely unknown. m. bovis was also the progenitor for the m. bovis bacillus calmette-guérin vaccine strain, the most widely used human vaccine. here we describe the 4,345,492-bp genome sequence of m. bovis af2122/97 and its comparison with the genomes of mycobact ... | 2003 | 12788972 |
| fine needle aspiration cytology of leprous neuritis. | to document the cytomorphologic features of leprous neuritis and their correlation with bacterial density. | 2003 | 12789916 |
| histoid leprosy: diagnosis by fine needle aspiration cytology. | | 2003 | 12789951 |
| assessment of cell mediated immunogenicity of mycobacterium leprae-derived antigens. | the antigenicity of mycobacterium leprae (m. leprae)-derived cell membrane fraction was examined using human dendritic cells (dcs). immature dcs internalized and processed the cell membrane components, and expressed m. leprae-derived antigens (ags) on their surface. the expression of mhc class ii, cd86, and cd83 ags on dcs and cd40 ligand (l)-associated il-12 p70 production from dcs were up-regulated by the membrane ags. moreover these stimulated dcs induced significantly higher level of interfe ... | 2003 | 12798309 |
| comparative studies of the cell structures of mycobacterium leprae and m. tuberculosis using the electron microscopy freeze-substitution technique. | the cell envelope and cytoplasmic architecture of the mycobacterium leprae thai-53 strain were examined using the freeze-substitution technique of electron microscopy and compared with those of the m. tuberculosis h37rv strain. both strains had similarly multilayered envelope architectures composed of an electron-translucent layer, a peptidoglycan layer and the plasma membrane, from outside to inside. a comparison of the structures of these two mycobacteria revealed that the m. leprae cell was s ... | 2003 | 12801063 |
| comparison of two different pcr amplification products (the 18-kda protein gene vs. rlep repetitive sequence) in the diagnosis of mycobacterium leprae. | to determine the best molecular method for diagnosing leprosy, two sets of mycobacterium leprae-specific primers were compared. fresh biopsies and slit skin smear samples were obtained from 67 leprosy patients and examined by touchdown (td) pcr using primers amplifying either a 129-bp fragment of the rlep repetitive sequence or a 360-bp fragment of the 18-kda protein gene of m. leprae. seventeen of 30 (56.7%) biopsy specimens and four of 37 (10.8%) slit skin smear specimens were positive using t ... | 2003 | 12823306 |
| reversal reaction to hansen's disease. | a 25-year-old man with a history of mid-borderline (bb) hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented. his clinical features included erythematous, edematous plaques and peripheral neuropathy. reversal reactions are caused immunologically by enhanced cell-mediated (th-1) immunity to mycobacterium leprae, resulting in inflammation of infected tissues, such as skin and nerves. acute neuritis can lead to permanent nerve damage and necessita ... | 2002 | 12847760 |
| t-cell recognition of peptides from the mycobacterium leprae 35 kda protein in thai leprosy patients, healthy contacts, and non-contacts. | the objective of the study was to identify mycobacterium leprae-specific immunogenic peptides for the development of a skin test reagent. such a reagent is required for the detection of m. leprae infection and possibly for the diagnosis of patients with active leprosy. for this purpose, we analyzed the in vitro responses of human peripheral blood mononuclear cell (pbmcs) to peptides from the 35 kda protein of m. leprae. this protein is of interest since it has no homologue within the mycobacteri ... | 2003 | 12853165 |
| gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis bcg-vaccinated malawian young adults. | we have previously shown that young adults living in a rural area of northern malawi showed greater gamma interferon (ifn-gamma) responses to purified protein derivatives (ppd) prepared from environmental mycobacteria than to ppd from mycobacterium tuberculosis. in order to define the mycobacterial species to which individuals living in a rural african population have been exposed and sensitized, we tested t-cell recognition of recombinant and purified antigens from m. tuberculosis (38 kda, mpt6 ... | 2003 | 12853392 |
| identification of strong promoter elements of mycobacterium smegmatis and their utility for foreign gene expression in mycobacteria. | the isolation of elements driving high-level expression of foreign genes in mycobacteria would significantly aid characterization of mycobacterial antigens and recombinant vaccine development. mycobacterium smegmatis is a widely employed host for recombinant mycobacterial gene expression. this report describes the identification of strong promoter elements of m. smegmatis. fluorescence-activated cell sorting was employed to isolate dna fragments permitting high-level expression of the aequorea v ... | 2003 | 12855181 |
| estimating the relative recurrence risk ratio for leprosy in karonga district, malawi. | leprosy is a chronic disease caused by infection with mycobacterium leprae. susceptibility to leprosy is influenced by both genetic and non-genetic factors and the disease is known to cluster in families. one measure of genetic effect is the relative recurrence risk ratio, lambdar. estimates of this parameter can be inflated if environmental risk factors which also cluster in families, such as household contact, are not properly accounted for. we present the results of fitting a cross ratio mode ... | 2003 | 12862254 |
| criteria for diagnosis of pure neural leprosy. | the clinical diagnosis of pure neural leprosy (pnl) remains a public health care problem mainly because skin lesions-the cardinal features of leprosy-are always absent.moreover, the identification of the leprosy bacillus is not easily achieved even when a nerve biopsy can be performed. in an attempt to reach a reliable pnl diagnosis in patients referred to our leprosy outpatient clinic, this study employed a variety of criteria. the nerve biopsies performed on the 67 individuals whose clinical, ... | 2003 | 12883921 |
| detection and quantification of mycobacterium leprae in tissue samples by real-time pcr. | real-time pcr technology has improved molecular diagnostics of many pathogens, but no such test is available for mycobacterium leprae. in this report we describe the establishment and the pre-clinical evaluation of such an assay. the test achieved a theoretical analytical sensitivity limit of 194 m. leprae cells per skin biopsy specimen and facilitated quantification of mycobacteria in tissue over a range of 54-54,000,000 cells per sample. in punch skin biopsies from 39 untreated ugandan patient ... | 2004 | 12884037 |
| leprosy in a mexican immigrant. | a new diagnosis of borderline lepromatous leprosy was established in a man who had immigrated to kentucky from mexico. he was placed on a world health organization treatment regimen consisting of dapsone, clofazimine, and rifampin. the biology of leprosy, its diagnosis, treatment, and worldwide impact are reviewed. because of the potential for highly mobile populations to export endemic diseases, kentucky physicians must expand their lists of differential diagnoses. | 2003 | 12886712 |
| a study on pcr for detecting infection with m. leprae. | so far, it has not been established a satisfactory method for early diagnosis and studying on epidemiology for leprosy, we want to develop a molecular biological method for solving this point. | 1999 | 12894900 |
| kinetic changes of antibody to m. leprae and its relation with clinical disease. | a sero-epidemiological survey on 1,833 healthy residents was carried out in 6 villages of a leprosy high-endemic area in wenshan and guangnan counties, yunnan province. the part of the residents with initially antibody-positive as well as the part of residents with initially antibody-negative have been followed up for 3 consecutive years by serology and clinical examination for studying kinetic changes of antibody to m. leprae and its relation with clinical disease. the results showed that the r ... | 1999 | 12899385 |
| preparation of recombinant alpha2 antigen of m. leprae in e. coli and the application for sero-diagnosis of leprosy. | | 1999 | 12901619 |
| is crohn's disease caused by a mycobacterium? comparisons with leprosy, tuberculosis, and johne's disease. | although crohn's disease is considered to be autoimmune in origin, there is increasing evidence that it may have an infectious cause. the most plausible candidate is mycobacterium avium subspecies paratuberculosis (map). intriguingly, koch's postulates may have been fulfilled for map and crohn's disease, even though they still have not been met for mycobacterium leprae and leprosy. in animals map causes johne's disease, a chronic wasting intestinal diarrhoeal disease evocative of crohn's disease ... | 2003 | 12901893 |
| degradation process of mycobacterium leprae cells in infected tissue examined by the freeze-substitution method in electron microscopy. | mycobacterium leprae cells (strain thai-53) harvested from infected mouse foot pads were examined by electron microscopy using the freeze-substitution technique. the population of m. leprae cells from the infected tissue consisted of a large number of degraded cells and a few normal cells. these thin sectioned cell profiles could be categorized into four groups depending on the alteration of the membrane structures, and the degradation process is considered to occur in stages, namely from stages ... | 2003 | 12906098 |
| [leprosy in brazil]. | leprosy or hansen's disease is a chronic infectious disease caused by the mycobacterium leprae. the skin and nervous manifestations of the disease present a singular clinical picture that is easily recognized. after india, brazil still is the second country with the greatest number of cases in the world. around 94% of the known cases and 94% of the new cases reported in america, come from brazil. the disease presents itself in two well-defined stable and opposite poles (lepromatous and tuberculo ... | 2003 | 12908039 |
| cured tuberculoid patients have a greater life expectancy than cured lepromatous patients in japan. | leprosy patients lack specific cellular immunity against mycobacterium leprae, but other immunological functions are thought to be preserved. however, in a leprosy sanatorium in south japan between 1982 and 2000, we found that the average age at death of cured lepromatous leprosy patients was about 5 yrs younger than that of cured tuberculoid patients; [male/lepromatous, 76.0 +/- 10.0 yrs old vs. male/tuberculoid, 79.7 +/- 9.4 yrs old, p = 0.026], and [female/lepromatous, 78.0 +/- 10.5 vs. femal ... | 2003 | 12914133 |
| epidemiology of leprosy. molecular, biological, and immunological approach. | leprosy is an infectious disease for which humans are considered the only source of infection. the major hindrance in leprosy control and thus in reaching the elimination goal is that numerous leprosy cases remain undetected for a long time. many of these patients are a continuous source of infection and, and hence perpetuate transmission. the goal of the world health organization (who) is to eliminate leprosy as a public problem by the year 2000; that is, to reach as a global prevalence of <1 p ... | 2003 | 12916799 |
| elimination of leprosy and its consequences for research. | | 2003 | 12916801 |
| [ziehl-neelsen-victoria blue-iodine green compound staining method showing leprotic bacillus]. | to compare compound staining methods showing leprotic bacillus, elastic fibre and cell nucleus etc. in skin biopsy tissue. | 2003 | 12920817 |
| [the painful multiple mononeuropathy of acute onset in the left arm which was diagnosed as leprous neuropathy]. | a 31-year-old man from myanmar with leprous neuropathy was reported. the progress of the disease was subacute but the painful symptom at the time of the onset was acute. multiple mononeuropathy was diagnosed by the biopsy findings of the left superficial radial nerve. he was admitted to our hospital with the complaint of the weakness of his left hand and fingers which were very painful and got worse in several weeks. motor palsy was observed in his left ulnar, median, and radial nerves, and ther ... | 2003 | 12931632 |
| american cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis coinfection with downregulation of the t-helper 1 cell response. | cutaneous leishmaniasis, leprosy, and tuberculosis are caused by intracellular pathogens whose development depends on impaired cell-mediated immunity. we report an exceptional triple association of american cutaneous leishmaniasis, lepromatous leprosy, and pulmonary tuberculosis in a man with no recognized immunodeficiency. normal immunological assessment of the interferon-gamma pathway does not support the hypothesis of a genetic defect in any of the genes involved in the t helper (th)-1 cytoki ... | 2003 | 12942392 |
| mycobacterium leprae binds to a major human peripheral nerve glycoprotein myelin p zero (p0). | we have previously shown that a major phosphorylated 25-kda glycoprotein of the human peripheral nerve binds to mycobacterium leprae. in the present study, we confirm that the 25-kda glycoprotein of the human peripheral nerve is myelin p zero (p0) by immunoprecipitation and western blot experiments using monoclonal antibodies to myelin p0. immunohistochemical studies on human nerve using these antibodies to myelin p0 exhibited a strong immunoreactivity to the myelin and schwann cells. myelin p0 ... | 2003 | 12945534 |
| [presence of mycobacterium leprae determined by the gram-weigert and ziehl histological methods and by the ziehl-gabbet smear technic; comparative study of 355 cases]. | | 1952 | 12994145 |
| a nonchromogenic culture of an acid-fast bacillus isolated from the nasal mucus of a leprosy patient; its virulence for laboratory animals. | | 1952 | 13010891 |
| comparison of susceptible and resistant rats for measuring the infectiousness of m. leprae murium after in vitro experimentation. | | 1952 | 13010892 |
| [crystal formations provoked by inoculation of various acid-resistant bacilli on the chorioallantois of the chick embryo]. | | 1953 | 13033391 |
| an attempt to confirm growth of mycobacterium leprae murium on chorioallantoic membrane of live chicken embryos. | | 1953 | 13061106 |
| the viability of mycobacterium leprae murium in tissue stored with dry ice. | | 1953 | 13061109 |
| [sudan black bn, staining of mycobacterium tuberculosis & lepraemurium, failure to stain mycobacterium leprae]. | | 1953 | 13066820 |
| human lepra bacilli exposed to sunlight will retain their acid fastness if they are first heated. | | 1953 | 13085870 |
| [bacteriology of leprosy]. | | 1952 | 13086124 |
| new method for staining mycobacteria in tissue sections. | | 1953 | 13103920 |
| [results obtained with souza araujo's leprolin in some manifestations of neurosyphilis]. | | 1953 | 13106190 |
| study of the morphological modifications of mycobacterium leprae during chemotherapy. | | 1953 | 13108344 |
| staining of mycobacterium leprae by the rio hortega silver method in frozen and paraffin sections. | | 1953 | 13108345 |
| an evaluation of chemotherapeutic agents in the control of experimental infections due to mycobacterium leprae murium. | | 1954 | 13114637 |
| fluorescence microscopy as a routine method for the detection of m. tuberculosis and m. leprae. | | 1954 | 13146300 |
| [cellular reactions and phagocytosis in guinea pigs inoculated intraperitoneally with living and dead mycobacterium leprae]. | | 1953 | 13148814 |
| differential staining for m. tuberculosis and m. leprae; a modification of the ziehl-neelsen stain. | | 1954 | 13175448 |
| [fixation of hansen's bacilli at the inoculation site of an injection of antitetanus anatoxin]. | | 1954 | 13182492 |
| [demonstration of mycobacterium leprae in sections in 532 cases of leprosy; comparative study of the ziehl-klingmüller and ziehl-wade-klingmüller methods]. | | 1953 | 13194977 |
| [comparative study of the lesions induced by intradermal injection of suspensions of mycobacterium leprae and mycobacterium tuberculosis in normal guinea pigs]. | | 1953 | 13194980 |
| [study of tuberculin sensitivity in normal guinea pigs inoculated experimentally with mycobacterium leprae, mycobacterium lepraemurium and mycobacterium tuberculosis]. | | 1953 | 13194981 |
| demonstration of mycobacterium leprae in sections in 532 cases of leprosy: comparative study between the ziehl-klingmuller and the wade-fite techniques. | | 1954 | 13211040 |
| the acid-fast staining properties of mycobacterium leprae. | | 1954 | 13216943 |
| [the possibility of the mycobacterium marianum being a leprosy bacillus]. | | 1954 | 13230612 |
| mycobacterium leprae in skin and nasal scrapings during sulfone treatment; a review of 146 cases. | | 1954 | 13232776 |
| [inoculation of mycobacterium leprae into the yolk sac of developing chick embryo]. | | 1954 | 13232781 |
| [leprolin in psychiatry]. | | 1955 | 13260037 |
| the application of histochemical methods in the study of the skin in leprosy; demonstration of bacillus-containing capillaries and axons by treatment for phosphatases. | | 1955 | 13262907 |
| [new methods of staining hansen's bacillus with tensio-active fuchsin]. | | 1956 | 13313297 |
| [differentiation of hansen's and koch's bacilli by staining with sudan black]. | | 1956 | 13313299 |
| [the bcg has antigenic similarity with hansen's bacillus upon which the mycobacterium marianum cannot prevail]. | | 1955 | 13329711 |
| observations on the morphology of mycobacterium leprae by ordinary optics, phase microscopy, and electron microscopy. | | 1955 | 13345498 |
| the contribution of neisser to the establishment of the hansen bacillus as the etiologic agent of leprosy and the so-called hansen-neisser controversy. | | 1955 | 13345503 |
| electron microscopy of the leprosy bacillus: a study of submicroscopical structure. | | 1956 | 13352374 |
| methods of cultivation of the hansen bacillus; slide culture; hemolysis-tube culture; direct inoculation of the liquid medium. | | 1956 | 13366484 |
| mycobacterium leprae murium: preservation by freeze-drying. | | 1956 | 13366486 |
| [not available]. | | 1955 | 13369129 |
| [mycobacterium leprae and mycobacterium tuberculosis; antigens; modifications applying to antigenic properties of bcg caused by the action of diverse solvents]. | | 1956 | 13395619 |
| histological reactions produced by experimental inoculation of mycobacterium leprae murium into the golden hamster (cricetus auratus). | | 1956 | 13405592 |
| action of histamine and antihistamine on the ingestion of murine leprosy bacilli by macrophages of the rat and the guinea-pig. | | 1956 | 13428378 |
| relative specificity of serologic tests for syphilis in mycobacterium leprae infection. | | 1957 | 13435237 |
| experience with antigen marianum in the treatment of leprosy. | | 1957 | 13476779 |
| [inoculation of mycobacterium leprae in rats fed with pro-oxidants diets. i. bacteriological results 7 months after inoculation]. | | 1957 | 13495568 |
| study of the morphology of mycobacteria leprae by electronmicroscopy. | | 1958 | 13515395 |
| [histological study of lesions induced by hansen's bacillus & mycobacterium marianum on the chorioallantoic membrane of the chick embryo]. | | 1957 | 13524998 |
| [inoculation of mycobacterium leprae in rats fed with pro-oxidant diets. ii. bacteriological results up to 10 months after the 1st reinoculation]. | | 1957 | 13529140 |
| [inoculation of mycobacterium leprae in rats fed with pro-oxidant diets. iii. a. bacteriological results up to 5 months after a 2d reinoculation. b. biological specificity of acid-fast bacilli found 7 months after the 2d reinoculation]. | | 1957 | 13529159 |
| intratesticular multiplication of mycobacterium leprae murium in normal and suramin-treated animals. | | 1957 | 13562946 |
| progressive experimental infection with mycobacterium leprae in a chimpanzee; a preliminary report. | | 1958 | 13576571 |
| electron microscopy of ultra-thin sections of lepra cells and mycobacterium leprae. | | 1958 | 13586951 |
| cultivation of the leprosy bacillus. | | 1958 | 13599502 |
| studies on the metabolism of murine leprosy bacilli. i. stimulating effect of mitochondria extract of rat liver on the metabolism of bacilli. | | 1958 | 13610559 |