| nasal cytokine responses to natural colds in asthmatic children. | the mechanisms by which viruses induce asthma exacerbations are not well understood. | 2012 | 23181789 |
| mortality attributable to 9 common infections: significant effect of influenza a, respiratory syncytial virus, influenza b, norovirus, and parainfluenza in elderly persons. | because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available. | 2012 | 22723641 |
| respiratory viruses in children hospitalized for acute lower respiratory tract infection in ghana. | acute respiratory tract infections are one of the major causes of morbidity and mortality among young children in developing countries. information on the viral aetiology of acute respiratory infections in developing countries is very limited. the study was done to identify viruses associated with acute lower respiratory tract infection among children less than 5 years. | 2012 | 22490115 |
| [clinical characteristics of bronchiolitis obliterans in pediatric patients]. | to analyze the clinical characteristics, image findings, laboratory examination, the therapeutic methods and clinical outcomes of bronchiolitis obliterans (bo) in pediatric patients. | 2012 | 22455631 |
| influenza and respiratory syncytial virus infections in british hajj pilgrims. | viral respiratory infections including influenza and respiratory syncytial virus (rsv) have been reported during the hajj among international pilgrims. to help establish the burden of these infections at the hajj, we set up a study to confirm these diagnoses in symptomatic british pilgrims who attended the 2005 hajj. uk pilgrims with symptoms of upper respiratory tract infection (urti) were invited to participate; after taking medical history, nasal swabs were collected for point-of-care testing ... | 2008 | 22460211 |
| retrospective use of next-generation sequencing reveals the presence of enteroviruses in acute influenza-like illness respiratory samples collected in south/south-east asia during 2010-2013. | emerging and re-emerging respiratory pathogens represent an increasing threat to public health. etiological determination during outbreaks generally relies on clinical information, occasionally accompanied by traditional laboratory molecular or serological testing. often, this limited testing leads to inconclusive findings. the armed forces research institute of medical sciences (afrims) collected 12,865 nasopharyngeal specimens from acute influenza-like illness (ili) patients in five countries ... | 2017 | 28779659 |
| no serological evidence that harbour porpoises are additional hosts of influenza b viruses. | influenza a and b viruses circulate among humans causing epidemics almost annually. while various hosts for influenza a viruses exist, influenza b viruses have been detected only in humans and seals. however, recurrent infections of seals in dutch coastal waters with influenza b viruses that are antigenetically distinct from influenza b viruses circulating among humans suggest that influenza b viruses have been introduced into this seal population by another, non-human, host. harbour porpoises ( ... | 2014 | 24551217 |
| the iminosugar uv-4 is a broad inhibitor of influenza a and b viruses ex vivo and in mice. | iminosugars that are competitive inhibitors of endoplasmic reticulum (er) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. a novel iminosugar, uv-4b, has recently been shown to provide protection against lethal infections with dengue and influenza a (h1n1) viruses in mice. in the current study, the breadth of activity of uv-4b against influenza was examined ex vivo and in vivo. efficacy of uv-4b against influenza a and b viruses was shown in prim ... | 2016 | 27072420 |
| prevention and control of influenza and dengue through vaccine development. | influenza and dengue are viral illnesses of global public health importance, especially among children. accordingly, these diseases have been the focus of efforts to improve their prevention and control. influenza vaccination offers the best protection against clinical disease caused by strains contained within the specific year's formulation. it is not uncommon for there to be a mismatch between vaccine strains and circulating strains, particularly with regards to the b lineages. for more than ... | 2013 | 23910031 |
| dengue haemorrhagic fever in burma. | although sporadic from 1965 to 1969, a major outbreak of dengue haemorrhagic fever (dhf) occurred for the first time in rangoon in 1970. since then the disease has occurred every year in rangoon and is now observed to be expanding to other urban areas in the country. the clinical diagnosis of dhf was confused by concurrent outbreaks of influenza a in 1971 and influenza a and b in 1972. a laboratory study of 3,447 clinically diagnosed haemorrhagic fever cases showed that 1643 cases (47.8%) were d ... | 1975 | 131977 |
| a review of clinical influenza a and b infections with reduced susceptibility to both oseltamivir and zanamivir. | anti-influenza drugs play major roles in the management of severe influenza infections. neuraminidase inhibitors (nais), which are active against all influenza a subtypes and the 2 major influenza b lineages, constitute the only class of antivirals recommended for the control of influenza epidemics and eventual pandemics. thus, the emergence of nai resistance could be a major clinical concern. although most currently circulating influenza a and b strains are susceptible to nais, clinical cases o ... | 2017 | 28852674 |
| influenza vaccine effectiveness against medically attended influenza illness in beijing, china, 2014/15 season. | influenza vaccination is the most effective way of preventing influenza infections but its coverage is extremely low in china. poor influenza vaccine effectiveness (ve) was reported in the 2014/15 season in some northern hemisphere countries with a predominance of h3n2 viruses belonging to the 3c.2a clade. however, there is limited information regarding the preventive effect of influenza vaccination for the same season in china, in which h3n2 viruses belonging to the 3c.3a clade predominated. th ... | 2017 | 28846480 |
| prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices - united states, 2017-18 influenza season. | this report updates the 2016-17 recommendations of the advisory committee on immunization practices (acip) regarding the use of seasonal influenza vaccines (mmwr recomm rep 2016;65[no. rr-5]). routine annual influenza vaccination is recommended for all persons aged ≥6 months who do not have contraindications. a licensed, recommended, and age-appropriate vaccine should be used.for the 2017-18 season, quadrivalent and trivalent influenza vaccines will be available. inactivated influenza vaccines ( ... | 2017 | 28841201 |
| secondary organizing pneumonia following viral pneumonia caused by severe influenza b: a case report and literature reviews. | some reported that organizing pneumonia (op) may occur after influenza a infections including swine-origin influenza a (h1n1). however, op associated with influenza b infection has never been reported. we report the first case of secondary op associated with viral pneumonia caused by influenza b. | 2017 | 28810835 |
| 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza a(h1n1)pdm09 and b among elderly people in europe: results from the i-move+ project. | we conducted a multicentre test-negative case-control study in 27 hospitals of 11 european countries to measure 2015/16 influenza vaccine effectiveness (ive) against hospitalised influenza a(h1n1)pdm09 and b among people aged ≥ 65 years. patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. information on demographics, vaccination and underlying conditions was collected. using logistic regression, we measured ive adjusted for pot ... | 2017 | 28797322 |
| influenza vaccine effectiveness in the united states during the 2015-2016 season. | the a(h1n1)pdm09 virus strain used in the live attenuated influenza vaccine was changed for the 2015-2016 influenza season because of its lack of effectiveness in young children in 2013-2014. the influenza vaccine effectiveness network evaluated the effect of this change as part of its estimates of influenza vaccine effectiveness in 2015-2016. | 2017 | 28792867 |
| immunogenicity and safety of influenza vaccination in patients with juvenile idiopathic arthritis on biological therapy using the microneutralization assay. | seasonal influenza virus vaccination should be considered in all pediatric patients with rheumatic diseases. few studies have addressed influenza vaccination safety and efficacy in this group. we aim to prospectively evaluate immunogenicity and safety of the trivalent inactivated influenza vaccine including a/h1n1, a/h3n2 and b strains in children with juvenile idiopathic arthritis (jia) receiving biological therapy. | 2017 | 28784185 |
| influenza vaccine effectiveness in adults based on the rapid influenza diagnostic test results, during the 2015/16 season. | we assessed the influenza vaccine effectiveness (ve) of an inactivated quadrivalent influenza vaccine in adult patients, in our test-negative case-control design study based on the results of a rapid influenza diagnostic test. during the 2015/16 season in japan, influenza a(h1n1)pdm09 virus and influenza b virus were epidemic. the overall adjusted ve was 44% (95% confidence interval [ci]: 13.6%-63.7%). the adjusted ve was 52.9% (95%ci: 20%-72.3%) against any influenza virus among those < 65 year ... | 2017 | 28668446 |
| seasonal influenza vaccine effectiveness against laboratory-confirmed influenza hospitalizations - latin america, 2013. | despite widespread utilization of influenza vaccines, effectiveness (ve) has not been routinely measured in latin america. | 2017 | 28648543 |
| effect of previous and current vaccination against influenza a(h1n1)pdm09, a(h3n2), and b during the post-pandemic period 2010-2016 in spain. | recent studies suggest that the protective effect of the current influenza vaccine could be influenced by vaccination in previous seasons. we estimated the combined effect of the previous and current influenza vaccines from the 2010-2011 season to the 2015-2016 season in spain. | 2017 | 28614376 |
| rapid identification of imported influenza viruses at xiamen international airport via an active surveillance program. | the cross-border transmission of infectious diseases is a worldwide public health issue. current border screening measures are insufficiently sensitive. the study objectives were to describe the epidemiologic pattern of influenza infection among incoming travellers at xiamen international airport during nonpandemic periods and to assess the performance of a rapid influenza diagnostic test in border screening. | 2017 | 28587905 |
| clinical and epidemiological characterization of influenza a/h1n1pdm and b among hospitalized children, georgia, season 2010-2011. | the aim of the study was to describe, analyze and compare clinical and epidemiological characteristics of laboratory confirmed influenza a(h1n1)pdm and b cases in hospitalized children during post pandemic season. between 1st january and 1st may, 2011 retrospective observational study was conducted in m. iashvili children's central hospital. from 1028 patients with influenza like illness hospitalized at children's hospital 871 specimens were collected and 360 tested positive for influenza: a(h1n ... | 2017 | 28577016 |
| [effectiveness of influenza vaccine in the netherlands: predominant circulating virus type and vaccine match are important conditions]. | to investigate the relationship between circulating influenza virus a types and subtypes and influenza b lineages, their match with the vaccine and the effectiveness of the influenza vaccine (ive). | 2017 | 28558853 |
| characterization and circulation of seasonal influenza viruses in madrid, 2010-2016. | influenza virus infection is a major health care burden and is associated with significant morbidity and mortality. the 2009 influenza pandemic highlighted the importance of influenza surveillance. the objective of this study was to assess the epidemiology and activity of influenza a and b viruses in adults and children in the post-pandemic period with a special focus on the pediatric population. we performed a retrospective descriptive study involving adults and children with influenza-like ill ... | 2017 | 28504416 |
| high prevalence of humoral and cellular immunity to influenza viruses in preschool children living in addis ababa, ethiopia. | influenza in children who reside in tropical and subtropical regions has until recently been regarded as insignificant. however, new evidence suggests that it significantly impacts hospitalization and promotes secondary bacterial coinfections. ethiopia is situated in a subtropical area where influenza viruses are likely to circulate year round. | 2017 | 28480294 |
| seroconversion and immunogenicity evaluation of seasonal influenza vaccine in mice model. | influenza virus is epidemiologically very important due to the antigenic variations occurring in it. in present study isolation and identification of influenza virus was attempted from kasauli and adjoining areas. 71 clinical samples i.e. throat washings were processed and inoculated into the eggs for virus isolation. the isolated strains of h3n2, h1n1 and influenza b were identified, purified and passaged in eggs. the harvested virus was inactivated by 0.03 % formalin and three formulations of ... | 2016 | 28466037 |
| influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, beijing, china. | vaccination is recommended to prevent influenza virus infection and associated complications. this study aimed to estimate the influenza vaccine effectiveness (ve) against hospitalization in the 2015/16 season in beijing. | 2017 | 28456530 |
| clinical differences of influenza subspecies among hospitalized children. | clinical findings, mortality, and morbidity rates differ among influenza subspecies. awareness of these differences will lead physicians to choose the proper diagnostic and therapeutic strategies and to foresee possible complications. the aim of this study was to evaluate the clinical differences of influenza subspecies among hospitalized children. | 2017 | 28439196 |
| retrospective review of epidemic viral pneumonia cases in turkey: a multicenter study. | influenza a (h1n1) caused its first pandemic in 2009 in usa and mexico. since then, clinicians have exercised great care in order to make an early diagnosis of viral pneumonias. this is due in part to pandemic influenza a infection having greater impact on populations <65 years old than other viral strains, including seasonal influenza. chest radiographies of those affected displayed a rapid progression of patchy infiltrates, and a large proportion of individuals required admission to intensive ... | 2017 | 28413489 |
| evolution of the neuraminidase gene of seasonal influenza a and b viruses in thailand between 2010 and 2015. | the neuraminidase inhibitors (nais) oseltamivir and zanamivir are commonly used for the treatment and control of influenza a and b virus infection. however, the emergence of new influenza virus strains with reduced susceptibility to nais may appear with the use of these antivirals or even naturally. we therefore screened the neuraminidase (na) sequences of seasonal influenza virus a(h1n1), a(h1n1)pdm09, a(h3n2), and influenza b virus strains identified in thailand for the presence of substitutio ... | 2017 | 28410396 |
| comparison of three rapid influenza diagnostic tests with digital readout systems and one conventional rapid influenza diagnostic test. | rapid influenza diagnostic tests (ridts) show variable sensitivities in clinical settings. we aimed to compare three digital ridts and one conventional ridt. | 2017 | 28407318 |
| immunogenicity and safety of a cell culture-derived inactivated quadrivalent influenza vaccine (nbp607-qiv): a randomized, double-blind, multi-center, phase iii clinical trial in adults and elderly subjects. | the influenza b virus has two lineages; yamagata and victoria. the two lineages are antigenically distinct and it is difficult to expect cross-protection between the lineages. actually, the mismatch between circulating influenza b viruses and vaccine strains has been occurred frequently. the cell-culture system for the production of influenza vaccine can contribute to improve vaccine strain selection and expand vaccine supplies. we investigated the immunogenicity and safety of cell culture-deriv ... | 2017 | 28406746 |
| severe acute respiratory infection (sari) surveillance for hospitalized patients in northern vietnam, 2011-2014. | worldwide severe acute respiratory infections (sari) are leading causes of hospitalization, morbidity and mortality in children. the aim of this study was to identify viral pathogens responsible for sari in northern vietnam from 2011 to 2014. | 2017 | 28367882 |
| two doses of inactivated influenza vaccine improve immune response in solid organ transplant recipients: results of transgripe 1-2, a randomized controlled clinical trial. | influenza vaccine effectiveness is not optimal in solid organ transplant recipients (sotr). we hypothesized that a booster dose might increase it. | 2017 | 28362949 |
| repeated vaccination does not appear to impact upon influenza vaccine effectiveness against hospitalization with confirmed influenza. | annual influenza vaccine is recommended for those at greatest risk of severe influenza infection. recent reports of a negative impact of serial influenza vaccination on vaccine effectiveness (ve) raises concerns about the recommendation for annual influenza vaccines, particularly in persons at greatest risk. | 2017 | 28329167 |
| predictors of influenza a molecular viral shedding in hutterite communities. | patterns of influenza molecular viral shedding following influenza infection have been well established; predictors of viral shedding however remain uncertain. | 2017 | 28207989 |
| update: influenza activity - united states, october 2, 2016-february 4, 2017. | this report summarizes u.s. influenza activity* during october 2, 2016-february 4, 2017,(†) and updates the previous summary (1). influenza activity in the united states began to increase in mid-december, remained elevated through february 4, 2017, and is expected to continue for several more weeks. to date, influenza a (h3n2) viruses have predominated overall, but influenza a (h1n1)pdm09 and influenza b viruses have also been identified. | 2017 | 28207684 |
| alkyl polyglycoside, a highly promising adjuvant in intranasal split influenza vaccines. | influenza viral infections are significant global public health concerns due to the morbidity and mortality associated with acute respiratory disease, secondary complications, and pandemic threats; thus, continuous efforts have been made to develop potent influenza vaccines. in this study, 3 different mucosal adjuvants-alkyl polyglycoside (apg), gellan gum, and chitosan (cs)-were evaluated for their efficacy in intranasal a/h1n1 or b split influenza vaccines administered to balb/c mice. protecti ... | 2017 | 28129034 |
| preexisting immunity, not frailty phenotype, predicts influenza postvaccination titers among older veterans. | both preexisting immunity to influenza and age have been shown to be correlates of influenza vaccine responses. frailty, an indicator of functional impairment in older adults, was also shown in one study to predict lower influenza vaccine responses among nonveterans. in the current study, we aimed to determine the associations between frailty, preexisting immunity, and immune responses to influenza vaccine among older veterans. we studied 117 subjects (age range, 62 to 95 years [median age, 81 y ... | 2017 | 28100496 |
| intraseason waning of influenza vaccine protection: evidence from the us influenza vaccine effectiveness network, 2011-12 through 2014-15. | recent studies suggest that influenza vaccine effectiveness (ve) may wane over the course of an influenza season, leading to suboptimal ve during late influenza seasons. | 2017 | 28039340 |
| an epidemiological analysis of summer influenza epidemics in okinawa. | objective this study evaluates the difference between winter influenza and summer influenza in okinawa. methods from january 2007 to june 2014, weekly rapid antigen test (rat) results performed in four acute care hospitals were collected for the surveillance of regional influenza prevalence in the naha region of the okinawa islands. results an antigenic data analysis revealed that multiple h1n1 and h3n2 viruses consistently co-circulate in okinawa, creating synchronized seasonal patterns and a h ... | 2017 | 27980256 |
| immunogenicity of trivalent influenza vaccines in patients with chronic kidney disease undergoing hemodialysis: mf59-adjuvanted versus non-adjuvanted vaccines. | patients with chronic kidney disease (ckd) are at an increased risk of morbidity and mortality from influenza. however, the immunogenicity of influenza vaccine is known to be attenuated in these patients. in this study, the immunogenicity of mf59-adjuvanted and non-adjuvanted trivalent influenza vaccines was compared in ckd patients undergoing hemodialysis (hd). | 2016 | 27802078 |
| invasive aspergillosis associated with severe influenza infections. | background. invasive aspergillosis may occur in the setting of severe influenza infections due to viral-induced respiratory epithelium disruption and impaired immune effects, but data are limited. methods. a retrospective study was conducted among severe influenza cases requiring medical intensive care unit (icu) admission at an academic center during the 2015-2016 season. data collected included respiratory cultures, medical conditions and immunosuppressants, laboratory and radiographic data, ... | 2016 | 27704024 |
| immunogenicity of as03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: a phase 3, randomized trial and post-hoc correlate of protection analysis. | in this study we describe the immunogenicity results from a subset of older people (n = 5187) who participated in a phase 3 randomized, observer-blinded trial of as03-tiv versus tiv (fluarix™) (clinicaltrials.gov, nct00753272). participants received one dose of as03-tiv or tiv in each study year and antibody titers against the vaccine strains were assessed using hemagglutination-inhibition (hi) assay at 21 d and 180 d post-vaccination in each vaccine group in the 2008/09 (year 1) and 2009/10 (ye ... | 2016 | 27690762 |
| effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the united kingdom: 2015/16 end-of-season results. | the united kingdom (uk) is in the third season of introducing universal paediatric influenza vaccination with a quadrivalent live attenuated influenza vaccine (laiv). the 2015/16 season in the uk was initially dominated by influenza a(h1n1)pdm09 and then influenza of b/victoria lineage, not contained in that season's adult trivalent inactivated influenza vaccine (iiv). overall adjusted end-of-season vaccine effectiveness (ve) was 52.4% (95% confidence interval (ci): 41.0-61.6) against influenza- ... | 2016 | 27684603 |
| sentinel surveillance for influenza among severe acute respiratory infection and acute febrile illness inpatients at three hospitals in ghana. | influenza epidemiology in africa is generally not well understood. using syndrome definitions to screen patients for laboratory confirmation of infection is an established means to effectively conduct influenza surveillance. | 2016 | 27239956 |
| humoral, t-cell and b-cell immune responses to seasonal influenza vaccine in solid organ transplant recipients receiving anti-t cell therapies. | we analyzed the impact of the anti-t-cell agents basiliximab and antithymocyte globulins (atg) on antibody and cell-mediated immune responses after influenza vaccination in solid-organ transplant recipients. | 2016 | 27219339 |
| influenza epidemiology among hospitalized children in stockholm, sweden 1998-2014. | influenza remains a common reason for the hospitalization of children. there is a need for long term studies that are also population based. we describe the epidemiology of severe influenza in a defined population 1998-2014. | 2016 | 27155498 |
| variability in the diagnostic performance of a bedside rapid diagnostic influenza test over four epidemic seasons in a pediatric emergency department. | we wanted to determine the diagnostic performance of a rapid influenza diagnostic test (ridt) used bedside in a pediatric emergency department (ped). this was a prospective study over four consecutive winters (2009-2013), comparing the results of a ridt (quickvue®) with rt-pcr in children admitted to a ped. among the 764 children included, we did not observe any significant differences in the diagnostic performance of ridt except during the h1n1 pandemic. the overall sensitivity of the test was ... | 2016 | 27139081 |
| pooled influenza vaccine effectiveness estimates for australia, 2012-2014. | data were pooled from three australian sentinel general practice influenza surveillance networks to estimate australia-wide influenza vaccine coverage and effectiveness against community presentations for laboratory-confirmed influenza for the 2012, 2013 and 2014 seasons. patients presenting with influenza-like illness at participating gp practices were swabbed and tested for influenza. the vaccination odds of patients testing positive were compared with patients testing negative to estimate inf ... | 2016 | 27125368 |
| influenza vaccine effectiveness in adults 65 years and older, denmark, 2015/16 - a rapid epidemiological and virological assessment. | in denmark, both influenza a(h1n1)pdm09 and influenza b co-circulated in the 2015/16 season. we estimated the vaccine effectiveness (ve) of the trivalent influenza vaccine in patients 65 years and older using the test-negative case-control design. the adjusted ve against influenza a(h1n1)pdm09 was 35.0% (95% confidence interval (ci): 11.1-52.4) and against influenza b 4.1% (95% ci: -22.0 to 24.7). the majority of influenza a(h1n1)pdm09 circulating in 2015/16 belonged to the new genetic subgroup ... | 2016 | 27101732 |
| identification of micrornas in throat swab as the biomarkers for diagnosis of influenza. | influenza is a serious worldwide disease that captures global attention in the past few years after outbreaks. the recent discoveries of microrna (mirna) and its unique expression profile in influenza patients have offered a new method for early influenza diagnosis. the aim of this study was to examine the utility of mirnas for the diagnosis of influenza. | 2016 | 26917988 |
| immunogenicity and safety of influenza vaccination in systemic lupus erythematosus patients compared with healthy controls: a meta-analysis. | to assess the immunogenicity and safety of influenza vaccine in patients with systemic lupus erythematosus (sle). | 2016 | 26845680 |
| [the 2015-2016 epidemic season in russia and the world: circulation of influenza viruses, trends in incidence, clinical aspects, and treatment algorithm]. | in the 2015-2016 epidemic season, there were dominant influenza a(h1n1)pdm09 strains (over 90%) among the circulating influenza viruses in most countries of the northern hemisphere and in russia. a study of the antigenic properties of influenza a(h1n1)pdm09 strains revealed no differences in those of vaccine virus. sequencing showed that there were amino acid substitutions in hemagglutinin (receptor binding and sa sites) and in the genes encoding internal proteins (pa, np, m1, and ns1). the rise ... | 2016 | 28635831 |
| immunogenicity of influenza vaccine for patients with inflammatory bowel disease on maintenance infliximab therapy: a randomized trial. | in patients with inflammatory bowel disease (ibd) on infliximab, data are limited on immune response to influenza vaccine and the impact of vaccine timing. the study aims were to evaluate immune responses to the influenza vaccine in ibd patients on infliximab and the impact of vaccine timing on immune responses. | 2016 | 26595551 |
| immunogenicity and safety of an inactivated quadrivalent influenza vaccine in us children 6-35 months of age during 2013-2014: results from a phase ii randomized trial. | viruses from 2 influenza b lineages co-circulate, leading to suboptimal protection with trivalent influenza vaccines (tiv). quadrivalent influenza vaccines (qiv) containing both lineages offer broader protection. | 2016 | 26407273 |
| immunogenicity and reactogenicity of an inactivated quadrivalent influenza vaccine administered intramuscularly to children 6 to 35 months of age in 2012-2013: a randomized, double-blind, controlled, multicenter, multicountry, clinical trial. | influenza attack rates are high in 6- to 35-month-old children; vaccines containing both lineages of influenza b (yamagata and victoria), in addition to the h3n2 and h1n1 antigens, may improve protection rates. | 2015 | 26336604 |
| effectiveness of trivalent inactivated influenza vaccine in children estimated by a test-negative case-control design study based on influenza rapid diagnostic test results. | we assessed vaccine effectiveness (ve) against medically attended, laboratory-confirmed influenza in children 6 months to 15 years of age in 22 hospitals in japan during the 2013-14 season. our study was conducted according to a test-negative case-control design based on influenza rapid diagnostic test (irdt) results. outpatients who came to our clinics with a fever of 38 °c or over and had undergone an irdt were enrolled in this study. patients with positive irdt results were recorded as cases, ... | 2015 | 26317334 |
| influenza vaccination during the first 6 months after solid organ transplantation is efficacious and safe. | preventing influenza infection early after transplantation is essential, given the disease's high mortality. a multicentre prospective cohort study in adult solid organ transplant recipients (sotr) receiving the influenza vaccine during four consecutive influenza seasons (2009-2013) was performed to assess the immunogenicity and safety of influenza vaccination in sotr before and 6 months after transplantation. a total of 798 sotr, 130 of them vaccinated within 6 months of transplantation and 668 ... | 2015 | 26232537 |
| randomized evaluation of live attenuated vs. inactivated influenza vaccines in schools (relatives) cluster randomized trial: pilot results from a household surveillance study to assess direct and indirect protection from influenza vaccination. | children are key drivers of influenza transmission. vaccinating school age children decreases influenza in the community. | 2015 | 26232348 |
| forecasting influenza epidemics in hong kong. | recent advances in mathematical modeling and inference methodologies have enabled development of systems capable of forecasting seasonal influenza epidemics in temperate regions in real-time. however, in subtropical and tropical regions, influenza epidemics can occur throughout the year, making routine forecast of influenza more challenging. here we develop and report forecast systems that are able to predict irregular non-seasonal influenza epidemics, using either the ensemble adjustment kalman ... | 2015 | 26226185 |
| age and sex differences in rates of influenza-associated hospitalizations in hong kong. | few studies have explored age and sex differences in the disease burden of influenza, although men and women probably differ in their susceptibility to influenza infections. in this study, quasi-poisson regression models were applied to weekly age- and sex-specific hospitalization numbers of pneumonia and influenza cases in the hong kong sar, people's republic of china, from 2004 to 2010. age and sex differences were assessed by age- and sex-specific rates of excess hospitalization for influenza ... | 2015 | 26219977 |
| influenza activity in thailand and occurrence in different climates. | this study observed influenza activity between june 2009 and july 2014 in thailand, a country in the northern hemisphere with a tropical climate, and compared the results to activity in the united states (us) and australia, which represent temperate climates in the northern and southern hemispheres, respectively. from thailand, a total of 17,416 specimens were collected from patients exhibiting influenza-like illnesses and subjected to real-time pcr for the detection of influenza viruses. for co ... | 2015 | 26191483 |
| comparative burden of influenza a/h1n1, a/h3n2 and b infections in children treated as outpatients. | few studies have directly compared the clinical impact of different types and subtypes of influenza viruses in children. | 2015 | 26181897 |
| on the relative role of different age groups in influenza epidemics. | the identification of key "driver" groups in influenza epidemics is of much interest for the implementation of effective public health response strategies, including vaccination programs. however, the relative importance of different age groups in propagating epidemics is uncertain. during a communicable disease outbreak, some groups may be disproportionately represented during the outbreak's ascent due to increased susceptibility and/or contact rates. such groups or subpopulations can be identi ... | 2015 | 26097505 |
| comparison of diagnostic test performance in a population of high risk young adults versus a general population presenting with influenza. | upper respiratory tract infection (uri) is a well-documented cause of morbidity, extra expense and lost training time among basic military trainees (bmts). | 2015 | 26071335 |
| factors associated with maintenance of antibody responses to influenza vaccine in older, community-dwelling adults. | little is known about factors associated with maintenance of hemagglutinin inhibition (hai) antibodies after influenza vaccination in older adults. | 2015 | 25903659 |
| characterizing the epidemiology, virology, and clinical features of influenza in china's first severe acute respiratory infection sentinel surveillance system, february 2011-october 2013. | after the 2009 influenza a(h1n1)pdm09 pandemic, china established its first severe acute respiratory infections (sari) sentinel surveillance system. | 2015 | 25885096 |
| long term effectiveness of adjuvanted influenza a(h1n1)pdm09 vaccine in children. | immunological studies have indicated that the effectiveness of as03 adjuvanted monovalent influenza a(h1n1)pdm09 vaccine (pandemrix) may be of longer duration than what is seen for non-adjuvanted seasonal influenza vaccines. sixty-nine percent of children 6 months-18 years of age in stockholm county received at least one dose of pandemrix during the 2009 pandemic. we studied the effectiveness of the vaccine during the influenza seasons 2010-2011 and 2012-2013 in children hospitalized with virolo ... | 2015 | 25869891 |
| immunogenicity of virosomal adjuvanted trivalent influenza vaccination in allogeneic stem cell transplant recipients. | influenza vaccination is generally recommended to hematopoietic stem cell transplant (hsct) recipients. however, the seasonal subunit vaccination response is frequently suboptimal, and alternate more efficient vaccination systems must be examined. we compared the immunogenicity of an adjuvanted virosomal influenza and subunit vaccine in hsct recipients. | 2015 | 25817044 |
| comparison of immune response to the influenza vaccine in obese and nonobese healthcare workers. | to determine whether there is a difference in antibody titers and functionality after receipt of the influenza vaccine for obese versus nonobese healthcare workers (hcw). | 2015 | 25695164 |
| randomized, controlled trial of high-dose influenza vaccine among frail residents of long-term care facilities. | despite vaccination, residents of long-term-care facilities (ltcfs) remain at high risk of influenza-related morbidity and mortality. more-effective vaccine options for this population are needed. | 2015 | 25525051 |
| [the 2013-2014 epidemic season. hospital monitoring and antiviral therapy for influenza ]. | to characterize the 2013-2014 epidemic season from the results of detection of influenza infection in patients; to provide the molecular genetic characteristics of the strains isolated from deceased patients. | 2014 | 25509893 |
| immunogenicity and safety of inactivated quadrivalent and trivalent influenza vaccines in children 18-47 months of age. | because inactivated trivalent influenza vaccines (tivs) contain 1 influenza b strain, whereas 2 lineages may co-circulate, b lineage mismatch is frequent. we assessed an inactivated quadrivalent influenza vaccine (qiv) containing both b lineages versus tiv in young children. | 2014 | 25386965 |
| antibody and cell-mediated immune response to whole virion and split virion influenza vaccine in patients with inflammatory bowel disease on maintenance immunosuppressive and biological therapy. | influenza vaccination is recommended for inflammatory bowel disease (ibd) patients on immunosuppressive therapy. the objective was to evaluate the antibody and cell-mediated immune response to the split and whole virion influenza vaccine in patients with ibd treated with anti-tnf-α and immunosuppressive therapy. | 2015 | 25384624 |
| update: influenza activity -- united states and worldwide, may 18-september 20, 2014. | during may 18-september 20, 2014, the united states experienced low levels of seasonal influenza activity overall. influenza a (h1n1)pdm09 (ph1n1), influenza a (h3n2), and influenza b viruses were detected worldwide and were identified sporadically in the united states. in august, two influenza a (h3n2) variant viruses (h3n2v) were detected in ohio. this report summarizes influenza activity in the united states and worldwide during may 18-september 20, 2014. | 2014 | 25275330 |
| evaluation of 3 rapid influenza diagnostic tests during the 2012-2013 epidemic: influences of subtype and viral load. | this article evaluates the performance of 3 rapid influenza diagnostic tests (ridts), in correlation with the influenza subtypes and the viral load. a total of 236 samples were prospectively analyzed with binaxnow influenza a/b, directigen ez flu a and b, and bionexia influenza a+b. the results were compared to cell cultures and real-time polymerase chain reaction. positive samples were further subtyped. thirty-seven samples were positive for influenza a, and 57, for influenza b. for a(h1n1), th ... | 2014 | 25241638 |
| implementation of influenza-like illness sentinel surveillance in togo. | the emergence of avian influenza a/h5n1 in 2003 as well as the pandemic influenza a (h1n1) pdm09 highlighted the need to establish influenza sentinel surveillance in togo. the ministry of health decided to introduce influenza to the list of diseases with epidemic potential. by april 2010, togo was actively involved in influenza surveillance. this study aims to describe the implementation of ili surveillance and results obtained from april 2010 to december 2012. | 2014 | 25239536 |
| influenza-like illness sentinel surveillance in one hospital in medellin, colombia. 2007-2012. | the city of medellin in colombia has almost no documentation of the causes of acute respiratory infections (aris). as part of an ongoing collaboration, we conducted an epidemiologic surveillance for influenza and other respiratory viruses. it described the influenza strains that were circulating in the region along with their distribution over time, and performing molecular characterization to some of those strains. this will contribute to the knowledge of local and national epidemiology. | 2015 | 25100179 |
| sentinel surveillance of influenza in burkina faso: identification of circulating strains during 2010-2012. | although influenza surveillance has recently been improved in some sub-saharan african countries, no information is yet available from burkina faso. | 2014 | 25074591 |
| live attenuated influenza vaccine. | cold-adapted ann arbor based live attenuated influenza vaccine (laiv) has been available in the usa since 2003. the vaccine is efficacious against influenza infection. features of laiv include: easy administration suitable for mass immunization, cross-reactivity to drifted strains for broader coverage, and establishment of herd immunity for control of influenza spread. annual seasonal laiv now contains four strains against influenza a h1n1, h3n2, influenza b-victoria, and b-yamagata lineages tha ... | 2015 | 25059893 |
| epidemiology and impact of influenza in mongolia, 2007-2012. | mongolia's health service began to conduct surveillance for influenza in the 1970s. this surveillance has become more comprehensive over time and now includes 155 sentinel sites in mongolia. in this study, we analyzed the epidemiological characteristics and impact of influenza using data from influenza surveillance in mongolia. | 2014 | 25043147 |
| 4flu - an individual based simulation tool to study the effects of quadrivalent vaccination on seasonal influenza in germany. | influenza vaccines contain influenza a and b antigens and are adjusted annually to match the characteristics of circulating viruses. in germany, influenza b viruses belonged to the b/yamagata lineage, but since 2001, the antigenically distinct b/victoria lineage has been co-circulating. trivalent influenza vaccines (tiv) contain antigens of the two a subtypes a(h3n2) and a(h1n1), yet of only one b lineage, resulting in frequent vaccine mismatches. since 2012, the who has been recommending vaccin ... | 2014 | 24993051 |
| epidemiology and viral etiology of the influenza-like illness in corsica during the 2012-2013 winter: an analysis of several sentinel surveillance systems. | influenza-like illness (ili) surveillance is important to identify circulating and emerging/reemerging strains and unusual epidemiological trends. the present study aimed to give an accurate picture of the 2012-2013 ili outbreak in corsica by combining data from several surveillance systems: general practice, emergency general practice, hospital emergency units, intensive care units, and nursing homes. twenty-eight respiratory viruses were retrospectively investigated from patients in general pr ... | 2014 | 24959929 |
| results from the first six years of national sentinel surveillance for influenza in kenya, july 2007-june 2013. | recent studies have shown that influenza is associated with significant disease burden in many countries in the tropics, but until recently national surveillance for influenza was not conducted in most countries in africa. | 2014 | 24955962 |
| a rationally designed form of the tlr5 agonist, flagellin, supports superior immunogenicity of influenza b globular head vaccines. | previously, we demonstrated that for h1n1 and h5n1 influenza strains, the globular head of the hemagglutinin (ha) antigen fused to flagellin of salmonella typhimurium fljb (stf2) is highly immunogenic in preclinical models and man (song et al. (2008) [13]; song et al. (2009) [14]; taylor et al. (2012) [12]). further we showed that the vaccine format, or point of attachment of the vaccine antigen to flagellin, can dramatically affect the immunogenicity and safety profile of the vaccine. however, ... | 2014 | 24950354 |
| 2012-2013 seasonal influenza vaccine effectiveness against influenza hospitalizations: results from the global influenza hospital surveillance network. | the effectiveness of currently licensed vaccines against influenza has not been clearly established, especially among individuals at increased risk for complications from influenza. we used a test-negative approach to estimate influenza vaccine effectiveness (ive) against hospitalization with laboratory-confirmed influenza based on data collected from the global influenza hospital surveillance network (gihsn). | 2014 | 24945510 |
| difference in immune response in vaccinated and unvaccinated swedish individuals after the 2009 influenza pandemic. | previous exposures to flu and subsequent immune responses may impact on 2009/2010 pandemic flu vaccine responses and clinical symptoms upon infection with the 2009 pandemic h1n1 influenza strain. qualitative and quantitative differences in humoral and cellular immune responses associated with the flu vaccination in 2009/2010 (pandemic h1n1 vaccine) and natural infection have not yet been described in detail. we designed a longitudinal study to examine influenza- (flu-) specific immune responses ... | 2014 | 24916787 |
| influenza activity - united states, 2013-14 season and composition of the 2014-15 influenza vaccines. | during the 2013-14 influenza season in the united states, influenza activity increased through november and december before peaking in late december. influenza a (h1n1)pdm09 (ph1n1) viruses predominated overall, but influenza b viruses and, to a lesser extent, influenza a (h3n2) viruses also were reported in the united states. this influenza season was the first since the 2009 ph1n1 pandemic in which ph1n1 viruses predominated and was characterized overall by lower levels of outpatient illness a ... | 2014 | 24898165 |
| the effectiveness of seasonal trivalent inactivated influenza vaccine in preventing laboratory confirmed influenza hospitalisations in auckland, new zealand in 2012. | few studies report the effectiveness of trivalent inactivated influenza vaccine (tiv) in preventing hospitalisation for influenza-confirmed respiratory infections. using a prospective surveillance platform, this study reports the first such estimate from a well-defined ethnically diverse population in new zealand (nz). | 2014 | 24768730 |
| peramivir and laninamivir susceptibility of circulating influenza a and b viruses. | influenza viruses collected from regions of asia, africa and oceania between 2009 and 2012 were tested for their susceptibility to two new neuraminidase inhibitors, peramivir and laninamivir. all viruses tested had normal laninamivir inhibition. however, 3·2% (19/599) of a(h1n1)pdm09 viruses had highly reduced peramivir inhibition (due to h275y na mutation) and <1% (6/1238) of influenza b viruses had reduced or highly reduced peramivir inhibition, with single occurrence of variants containing i2 ... | 2014 | 24734292 |
| influenza in seasons 2009-2013 in the faculty hospital hradec kralove, east bohemia. | the evaluation of four post-pandemic influenza seasons 2009-2013 in the faculty hospital hradec králové and comparison of used rapid antigen tests (rats) with real time rt-pcr. | 2014 | 24730989 |
| effects of vaccination and the new neuraminidase inhibitor, laninamivir, on influenza infection. | evidence of the effectiveness of influenza vaccination in children and elderly adults is limited, although this population has the highest risk for influenza infection. | 2014 | 24699254 |
| immunogenicity and safety of a trivalent inactivated 2010-2011 influenza vaccine in taiwan infants aged 6-12 months. | this prospective study aimed to investigate the immune responses and safety of an influenza vaccine in vaccine-naïve infants aged 6-12 months, and was conducted from november 2010 to may 2011. fifty-nine infants aged 6-12 months received two doses of trivalent inactivated influenza vaccine 4 weeks apart. hemagglutination inhibition titers were measured 4 weeks after the two doses of study vaccine. based on the assumption that a hemagglutination inhibition titer of 1:40 or greater against the ant ... | 2014 | 24625341 |
| influenza vaccine effectiveness estimates in europe in a season with three influenza type/subtypes circulating: the i-move multicentre case-control study, influenza season 2012/13. | in the fifth season of influenza monitoring vaccine effectiveness in europe (i-move), we undertook a multicentre case-control study (mccs) in seven european union (eu) member states to measure 2012/13 influenza vaccine effectiveness against medically attended influenza-like illness (ili) laboratory confirmed as influenza. the season was characterised by substantial co-circulation of influenza b, a(h1n1)pdm09 and a(h3n2) viruses. practitioners systematically selected ili patients to swab ≤7 days ... | 2014 | 24556348 |
| immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged ≥18 years: a phase iii, randomized trial. | two influenza b lineages have been co-circulating since the 1980s, and because inactivated trivalent influenza vaccine (tiv) contains only one b strain, it provides little/no protection against the alternate b-lineage. we assessed a candidate inactivated quadrivalent influenza vaccine (qiv) containing both b lineages versus tiv in healthy adults. | 2014 | 24486352 |
| influenza a/subtype and b/lineage effectiveness estimates for the 2011-2012 trivalent vaccine: cross-season and cross-lineage protection with unchanged vaccine. | we estimate vaccine effectiveness (ve) against both influenza a/subtypes and b/lineages in canada for the 2011-2012 trivalent inactivated influenza vaccine (tiv) with components entirely unchanged from the 2010-2011 tiv and in the context of phenotypic and genotypic characterization of circulating viruses. | 2014 | 24446529 |
| seasonal influenza vaccine effectiveness against influenza in 2012-2013: a hospital-based case-control study in lithuania. | due to scarce information on seasonal influenza vaccine effectiveness (sive) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season. | 2014 | 24370711 |
| neurological manifestations of influenza infection in children and adults: results of a national british surveillance study. | the emergence of influenza a(h1n1) 2009 was met with increased reports of associated neurological manifestations. we aimed to describe neurological manifestations of influenza in adults and children in the united kingdom that presented at this time. | 2014 | 24352349 |
| neutralization positive but apparent false-positive hepatitis b surface antigen in a blood donor following influenza vaccination. | we report a case of transient, confirmed positive hepatitis b surface antigen (hbsag) in a 25 year old long term canadian blood services (cbs) donor, who reported receiving 2011-2012 seasonal trivalent (a/h1n1, a/h3n2, influenza b) inactivated influenza vaccine two days before donation. to our knowledge, this report is the first published case implicating influenza vaccine as a possible factor in false-positive hbsag test results. seasonal incidence of repeat-reactive hbsag among cbs donors sugg ... | 2014 | 24268563 |