| n-acetylcysteine prevents the development of gastritis induced by helicobacter pylori infection. | helicobacter pylori (h. pylori) is a human gastric pathogen, causing various gastric diseases ranging from gastritis to gastric adenocarcinoma. it has been reported that combining n-acetylcysteine (nac) with conventional antibiotic therapy increases the success rate of h. pylori eradication. we evaluated the effect of nac itself on the growth and colonization of h. pylori, and development of gastritis, using in vitro liquid culture system and in vivo animal models. h. pylori growth was evaluated ... | 2017 | 28455589 |
| accuracy of testing for anti-helicobacter pylori igg in urine for h. pylori infection diagnosis: a systematic review and meta-analysis. | this meta-analysis aims to systematically measure the potential diagnostic value of anti-helicobacter pylori igg in urine for infection diagnosis, using all eligible studies published in english and chinese languages. | 2017 | 28455424 |
| variations in the multimerization region of the helicobacter pylori cytotoxin caga affect virulence. | helicobacter pylori colonizes the human stomach by infecting gastric epithelial cells. it is the primary cause of peptic ulcer disease and gastric cancer (gc). cytotoxin-associated gene a (caga) is a virulence factor produced by h. pylori. strains positive for the caga protein are associated with more severe gastric diseases. the 3' region of the caga gene exhibits heterogeneity with respect to tyrosine phosphorylation motifs (epiya) and caga multimerization motifs (cm). caga proteins are catego ... | 2017 | 28454275 |
| associations between cytokine gene polymorphisms and susceptibility to helicobacter pylori infection and helicobacter pylori related gastric cancer, peptic ulcer disease: a meta-analysis. | the aim of this study is to clarify the associations between il-1b31c/t, il-1b-511c/t, il-8-251t/a gene polymorphisms and the risk of helicobacter pylori (h. pylori) infection together with h. pylori-related gastric cancer (gc), peptic ulcer disease (pud). | 2017 | 28453551 |
| impact of gluten consumption in patients with functional dyspepsia: a case-control study. | dietary factors and immune dysfunction may induce symptoms in patients with functional dyspepsia (fd). aim of the study was to evaluate whether gluten consumption impacts symptom onset in patients with fd and to evaluate for possible histologic alterations in the duodenum of patients with fd. | 2017 | 28452428 |
| functional dyspepsia: advances in diagnosis and therapy. | functional dyspepsia (fd) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. epidemiologically, there are two clinically distinct fd syndromes (although these often overlap clinically): postprandial distress syndrome (pds; comprising early satiety or meal-related fullness) and epigastric pain syndrome. symptoms of gastroesophageal reflux disease overlap with fd more than expected by chance; a subset has path ... | 2017 | 28452210 |
| effects of helicobacter pylori treatment on rosacea: a single-arm clinical trial study. | rosacea is a chronic dermatological disease. helicobacter pylori has been discussed as one of its causative factors. in this clinical trial study, we attempted to evaluate the effect of h. pylori standard eradication protocol on the rosacea clinical course. in this single-arm clinical trial, patients ascertained to have h. pylori infection based on serological studies were assessed to examine existence of rosacea. patients with concurrent rosacea and h. pylori infection were included in the stud ... | 2017 | 28452093 |
| helicobacter pylori recurrence after eradication in latin america: implications for gastric cancer prevention. | to estimate helicobacter pylori (h. pylori) recurrence rate in latin america, a region with a significant h. pylori prevalence and gastric cancer burden. | 2017 | 28451066 |
| screening endoscopy finds high prevalence of helicobacter pylori and intestinal metaplasia in korean american with limited access to health care. | gastric cancer (gc) is the leading cause of cancer death among korean americans. prevention and early detection is improved by screening. | 2017 | 28445591 |
| pharmaceutical equivalence of clarithromycin oral dosage forms marketed in nairobi county, kenya. | clarithromycin is a broad-spectrum semi-synthetic macrolide indicated for treatment of pneumonias, helicobacter pylori, and chlamydial and skin infections. the object of this study was to evaluate the pharmaceutical equivalence of 14 generic clarithromycin products marketed in nairobi county, kenya, to the innovator products, using in vitro dissolution profiles and similarity factors (f₂). further, dissolution profiles of four innovator formulations manufactured in different sites were compared. ... | 2017 | 28445444 |
| association of caga epiya-d or epiya-c phosphorylation sites with peptic ulcer and gastric cancer risks: a meta-analysis. | increasingly, studies have focused on the relationship between helicobacter pylori (h pylori) cytotoxin associated gene a protein (caga) glu-pro-ile-tyr-ala (epiya)-d motifs or multiple epiya-c phosphorylation sites and peptic ulcer disease (pud) or gastric cancer (gc) risk. however, the conclusions have been inconsistent. the aim of this meta-analysis was to evaluate whether 1 caga epiya-d motif or multiple epiya-c phosphorylation sites were associated with pud or gc risk. | 2017 | 28445260 |
| erratum to: braf, kras and helicobacter pylori epigenetic changes-associated chronic gastritis in egyptian patients with and without gastric cancer. | | 2017 | 28444545 |
| role of flagella in the pathogenesis of helicobacter pylori. | this review aimed to investigate the role of helicobacter pylori flagella on the pathogenicity of this bacterium in humans. helicobacter pylori is a flagellated pathogen that colonizes the human gastroduodenal mucosa and produces inflammation, and is responsible for gastrointestinal disease. its pathogenesis is attributed to colonization and virulence factors. the primary function of h. pylori flagella is to provide motility. we believe that h. pylori flagella play an important role in the colon ... | 2017 | 28444418 |
| gene expression profiling of transcription factors of helicobacter pylori under different environmental conditions. | helicobacter pylori is a gram-negative bacterium that colonizes the human gastric mucosa and causes peptic ulcers and gastric carcinoma. h. pylori strain 26695 has a small genome (1.67 mb), which codes for few known transcriptional regulators that control bacterial metabolism and virulence. we analyzed by qrt-pcr the expression of 16 transcriptional regulators in h. pylori 26695, including the three sigma factors under different environmental conditions. when bacteria were exposed to acidic ph, ... | 2017 | 28443084 |
| association of genetic variations in il-6/il-6r pathway genes with gastric cancer risk in a chinese population. | interleukin-6 (il-6) and its receptor (il-6r) were regarded to be responsible for the occurrence of gastric cancer for their regulation roles in the inflammation. the genetic variations in these two genes (il-6: rs6949149, rs1800796, rs10499563 and il-6r: rs2228145) have been suggested to be associated with gastric cancer risk. however, the published results were inconsistent among subjects of different ethnicity. to evaluate such an association in chinese population, we carried out this case-co ... | 2017 | 28442395 |
| tim-3 up-regulation in patients with gastric cancer and peptic ulcer disease | background: t-cell immunoglobulin and mucin domain protein-3 (tim-3), an inhibitory immunoregulatory receptor, has been recently implicated in tumor biology and tumor-associated immune suppression. in the present study, expression of tim-3 was evaluated in gastric cancer (gc) and peptic ulcer disease (pud) at both mrna and protein levels. methods: a total of 133 gastric tissue biopsies, comprising 43 from gc cases, 48 from pud and 42 from non-ulcer dyspepsia (nud) serving as controls were collec ... | 2017 | 28441784 |
| gastric ulcer hemorrhage - a potential life-threatening complication of intragastric balloon treatment of obesity. | some morbidly obese patients do not qualify for bariatric surgery due to general health contraindications. intragastric balloon treatment might be a therapeutic option in the above-mentioned cases. it can prime super-obese patients with end-stage disease for bariatric surgery. as a neoadjuvant therapy before surgery, it leads to a downstage of the disease by preliminary weight reduction, to an improvement in general health and, in summary, to a reduction of the perioperative risk. it is generall ... | 2017 | 28441654 |
| low re-infection rate of helicobacter pylori after successful eradication in thailand: a 2 years study | background: h. pylori is an important cause of chronic gastritis, peptic ulcers and gastric cancer. re-infection rates after successful eradication vary in different regions of the world but only limited studies have been performed in asean countries to clarify this important issue. the present study was designed to evaluate the h. pylori re-infection rate and predictors of re-infection in thailand. methods: we recruited patients with chronic gastritis after 1 and 2 years successful h. pylori er ... | 2017 | 28440977 |
| antibiotic susceptibility of helicobacter pylori in iceland. | increasing resistance of helicobacter pylori (h. pylori) to antibiotics calls for constant re-evaluation of multidrug regimens that have been used to eradicate the infection. the aim of this study was to evaluate the current antibiotic susceptibility of h. pylori in an icelandic cohort. | 2017 | 28440099 |
| genetic variants of helicobacter pylori type iv secretion system components cagl and cagi and their association with clinical outcomes. | helicobacter pylori infection is associated with risk for chronic gastritis (cg), gastric ulcer (gu), duodenal ulcer (du), and gastric cancer (gc). the h. pylori cag type iv secretion system (tfss) translocates the virulence factor cytotoxin-associated gene a protein into host cells and plays an important role in initiating gastric carcinogenesis. the cagl and cagi proteins are components of the tfss. the arg-gly-asp (rgd) motif of cagl, and the six most distal c-terminal amino acids (ser-lys-il ... | 2017 | 28439300 |
| correlation between expression of the cancer/testis antigen kk-lc-1 and helicobacter pylori infection in gastric cancer. | our previous study indicated that kita-kyushu lung cancer antigen-1 (kk-lc-1) is a cancer/testis antigen (cta) expressed in 82% of gastric cancer cases. here, we investigated the relationship between kk-lc-1 expression and helicobacter pylori infection in japanese patients with gastric cancer. | 2017 | 28438869 |
| ezh2 overexpression in primary gastrointestinal diffuse large b-cell lymphoma and its association with the clinicopathological features. | gastrointestinal diffuse large b-cell lymphoma (gi dlbcl) is the most common gastrointestinal lymphoma. enhancer of zeste homolog 2 (ezh2) has been implicated in the pathogenesis of several cancers. however, ezh2 has not been studied in gi dlbcl. thus, we investigated ezh2 expression and ezh2 y641 mutation in 100 gi dlbcl specimens by immunohistochemistry and sequencing. in addition, trimethylated h3k27 (h3k27me3), bcl2, c-myc, and ki-67 expression and helicobacter pylori infection were detected ... | 2017 | 28438623 |
| prevalence of helicobacter pylori infection among children living in a rural setting in sub-saharan africa. | helicobacter pylori infection affects more than half of the world's population. it is generally acquired during childhood with no symptoms but has long- term clinical sequelae. this study estimated the prevalence of h. pylori infection amongst children in a rural environment in africa. | 2017 | 28438158 |
| prevalence of helicobacter pylori infection among blood donors in saxony-anhalt, germany - a region at intermediate risk for gastric cancer. | background in the federal state of saxony-anhalt, gastric cancer (gc) incidence ranks among the highest in germany. helicobacter pylori prevalence is a surrogate marker for gc risk in a given population. in 2010 we reported an h. pylori seroprevalence of 44.4 % in patients at the emergency ward of the university hospital of magdeburg, the capital of saxony-anhalt. our aim is to update these findings in a cohort of healthy blood donors from the same region. materials and methods the sera of 516 c ... | 2017 | 28437803 |
| reduced infectivity of waterborne viable but nonculturable helicobacter pylori strain ss1 in mice. | helicobacter pylori infection has been consistently associated with lack of access to clean water and proper sanitation, but no studies have demonstrated that the transmission of viable but nonculturable (vbnc) h. pylori can occur from drinking contaminated water. in this study, we used a laboratory mouse model to test whether waterborne vbnch. pylori could cause gastric infection. | 2017 | 28436616 |
| the expression of helicobacter pylori tfs plasticity zone cluster is regulated by ph and adherence, and its composition is associated with differential gastric il-8 secretion. | helicobacter pylori virulence is associated with different clinical outcomes. the existence of an intact dupa gene from tfs4b cluster has been suggested as a predictor for duodenal ulcer development. however, the role of tfs plasticity zone clusters in the development of ulcers remains unclear. we studied several h. pylori strains to characterize the gene arrangement of tfs3 and tfs4 clusters and their impact in the inflammatory response by infected gastric cells. | 2017 | 28436598 |
| the correlation between histological gastritis staging- 'olga/olgim' and serum pepsinogen test in assessment of gastric atrophy/intestinal metaplasia in china. | serum pepsinogen (pg) test, as an indicator of gastric mucosal atrophy, reflects the functional and morphologic status of gastric mucosal and it is suggested to serve as a useful predictive marker for patients with gastric cancer (gc). the available classifications of gastritis, known as the operative link on gastritis assessment (olga) and operative link on gastritis intestinal metaplasia (olgim), integrating the severity and topography of atrophy/intestinal metaplasia (im), have been gradually ... | 2017 | 28436254 |
| genotyping of helicobacter pylori shows high diversity of strains circulating in central vietnam. | in vietnam, the high prevalence of helicobacter pylori infection represents a serious health problem. virulence genes of h. pylori have been associated to increased risk of severe gastrointestinal diseases and the genetic background differs in geographical areas. we investigated caga and vaca genotypes of h. pylori from dyspeptic patients from central vietnam and the correlation with clinical outcomes; we also performed sequencing analysis of partial caga gene. overall, 84% of strains were caga- ... | 2017 | 28434988 |
| a potential impact of helicobacter pylori infection on both obstructive sleep apnea and atrial fibrillation-related stroke. | | 2017 | 28434882 |
| lactobacillus paracasei strain 06tca19 suppresses inflammatory chemokine induced by helicobacter pylori in human gastric epithelial cells. | helicobacter (h.) pylori infection is an important risk factor for gastric cancer that causes gastric inflammation. inflammatory chemokines such as interleukin (il)-8 and regulated on activation normal t cell expressed and secreted (rantes) are elevated in the gastric mucosa by h. pylori. this study aimed to investigate the effects of lactobacillus paracasei strain 06tca19, a probiotic strain, on il-8 and rantes expression and production induced by h. pylori using human gastric epithelial cell l ... | 2017 | 28434172 |
| helicobacter pylori cagl amino acid polymorphism d58e59 pave the way toward peptic ulcer disease while n58e59 is associated with gastric cancer in north of iran. | the cagl protein of helicobacter pylori involving in pathogenesis of gastroduodenal disorders. therefore, the current study was conducted to determine the cagl amino acid polymorphisms in patients with gastric diseases. one hundred gastric biopsies were collected from gastritis, peptic ulcer (pud) and gastric cancer (gc) patients and were screened for cagl using polymerase chain reaction (pcr). also, sequence variations of the cagl were assessed via sequence translation. the cagl geneopositivity ... | 2017 | 28433795 |
| a bacterial cause of cancer: an historical essay. | this article reviews the history of the discovery of microbes that increase the risk of cancer of some tissues with a special emphasis on the bacterium helicobacter pylori and the role played by two australian physicians, neither schooled in research, who had open minds about the shibboleth that mycobacteria (acid-fast organisms) can survive the acid environment of the stomach, but that other pathogenic bacteria cannot. they discovered one of the most important human pathogens, helicobacter pylo ... | 2017 | 28432224 |
| helicobacter pylori outer membrane vesicles inhibit human t cell responses via induction of monocyte cox-2 expression. | the modulation of t cell responses by helicobacter pylori is thought to potentiate both h. pylori persistence and development of gastric pathologies including cancer. release of outer membrane vesicles (omv) by h. pylori provides a potential vehicle for modulation of the immune system. although omv are thought to have t cell suppressive activity, this has not yet been demonstrated. their suppressive activity was investigated in this study using the responses of peripheral blood mononuclear cells ... | 2017 | 28430970 |
| toll-like receptor 2: an important immunomodulatory molecule during helicobacter pylori infection. | toll like receptors (tlrs) are an essential subset of pathogen recognition receptors (prrs) which identify the microbial components and contribute in the regulation of innate and adaptive immune responses against the infectious agents. the tlrs, especially tlr2, tlr4, tlr5 and tlr9, participate in the induction of immune response against h. pylori. tlr2 is expressed on a number of immune and non-immune cells and recognizes a vast broad of microbial components due to its potential to form heterod ... | 2017 | 28427896 |
| smoking increases the likelihood of helicobacter pylori treatment failure. | data regarding the impact of smoking on the success of helicobacter pylori (h. pylori) eradication are conflicting, partially due to the fact that sociodemographic status is associated with both smoking and h. pylori treatment success. we aimed to assess the effect of smoking on h. pylori eradication rates after controlling for sociodemographic confounders. | 2017 | 28427781 |
| from inflammation to gastric cancer - the importance of hedgehog/gli signaling in helicobacter pylori-induced chronic inflammatory and neoplastic diseases. | infections with the human pathogen helicobacter pylori (h. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. drastic changes in the micromilieu involve a complex network of h. pylori-regulated signal transduction pathways leading to the release of proinflammatory cytokines, gut hormones and a wide range of signaling molecules. besides controlling embryonic development, the hedgehog/gli signaling pathway also pla ... | 2017 | 28427431 |
| correction: helicobacter pylori bab paralog distribution and association with caga, vaca, and homa/b genotypes in american and south korean clinical isolates. | [this corrects the article doi: 10.1371/journal.pone.0137078.]. | 2017 | 28426827 |
| endoscopic gastric mucosal atrophy distinguishes the characteristics of superficial esophagogastric junction adenocarcinoma. | western studies have suggested two distinct etiologies of esophagogastric junction (egj) cancer: helicobacter pylori-associated atrophic gastritis and non-atrophic gastric mucosa resembling esophageal adenocarcinoma. the present study investigated whether endoscopic gastric mucosal atrophy can distinguish between these two types of egj adenocarcinoma. | 2017 | 28425653 |
| efficacy of helicobacter pylori eradication therapies in korea: a systematic review and network meta-analysis. | the efficacy of helicobacter pylori eradication regimens may depend on the country where the studies were performed because of the difference in antibiotic resistance. we aimed to analyze the efficacy of h. pylori eradication regimens in korea where clarithromycin resistance rate is high. | 2017 | 28425141 |
| global fecal and plasma metabolic dynamics related to helicobacter pylori eradication. | background:helicobacter pylori colonizes the gastric mucosa of more than half of the world's population. there is increasing evidence h. pylori protects against the development of obesity and childhood asthma/allergies in which the development of these diseases coincide with transient dysbiosis. however, the mechanism underlying the association of h. pylori eradication with human metabolic and immunological disorders is not well-established. in this study, we aimed to investigate the local and s ... | 2017 | 28424674 |
| increased expression of deleted in malignant brain tumors (dmbt1) gene in precancerous gastric lesions: findings from human and animal studies. | helicobacter pylori infection triggers a cascade of inflammatory stages that may lead to the appearance of non-atrophic gastritis, multifocal atrophic, intestinal metaplasia, dysplasia, and cancer. deleted in malignant brain tumors 1 (dmbt1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in host defense by binding to pathogens. initial studies showed its deletion and loss of expression in a variety of tumors but the role of this gene i ... | 2017 | 28423364 |
| helicobacter pylori infection and serum leptin, obestatin, and ghrelin levels in mexican schoolchildren. | backgroundthere is little information about the possible role of helicobacter pylori infection on appetite-regulating peptides in children. this study evaluated the association between h. pylori infection and serum levels of ghrelin, leptin, and obestatin in schoolchildren.methodsone hundred seventy-eight schoolchildren, students at boarding schools in mexico city, participated. h. pylori infection status was determined every 6 months for 1 year by a breath test using (13)c-urea; schoolchildren ... | 2017 | 28422951 |
| gastritis in patients undergoing sleeve gastrectomy: prevalence, ethnic distribution, and impact on glycemic. | laparoscopic sleeve gastrectomy (lsg) is a therapeutic option in severely obese patients. the aim of this study was to evaluate the presence of helicobacter pylori (hp) gastritis and non-helicobacter gastritis in the gastrectomy specimens, and its association to other variables.one hundred six sleeve gastrectomy specimens were examined histopathologically for the presence of gastritis and its relation to other factors like ethnicity, glycemic control, and postoperative complications.twelve patie ... | 2017 | 28422853 |
| mismatch between probiotic benefits in trials versus food products. | probiotic food products contain a variety of different bacterial strains and may offer different health effects. the objective was to document the prevalence and dosage of probiotic strains in the canadian food supply and to review the literature investigating these strains in order to understand what health benefits these products may offer. the food label information program was used to identify probiotic-containing products in the food supply. pubmed, web of science, and embase were searched ... | 2017 | 28422059 |
| status of epstein-barr virus coinfection with helicobacter pylori in gastric cancer. | epstein-barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (gc). the persistent infection causes malignancies in lymph and epithelial cells. helicobacter pylori causes gastritis in human with chronic inflammation. this chronic inflammation is thought to be the cause of genomic instability. about 45%-word population have a probability of having both pathogens, namely, h. p ... | 2017 | 28421114 |
| plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia. | whether plasma ghrelin/obestatin levels are associated with helicobacter pylori (h. pylori) infection, subtypes of functional dyspepsia (fd), and gastric mucosal histology has not yet been established in elderly patients. | 2017 | 28419119 |
| management of helicobacter pylori infection. | | 2017 | 28418469 |
| host determinants of expression of the helicobacter pylori baba adhesin. | expression of the helicobacter pylori blood group antigen binding adhesin a (baba) is more common in strains isolated from patients with peptic ulcer disease or gastric cancer, rather than asymptomatic colonization. here we used mouse models to examine host determinants that affect h. pylori baba expression. baba expression was lost by phase variation as frequently in wt mice as in rag2-/- mice that do not have functional b or t cells, and in myd88-/-, tlr2-/- and tlr4-/- mice that are defective ... | 2017 | 28418004 |
| relevance of dna repair gene polymorphisms to gastric cancer risk and phenotype. | variations in dna repair genes have been reported as key factors in gastric cancer (gc) susceptibility but results among studies are inconsistent. we aimed to assess the relevance of dna repair gene polymorphisms and environmental factors to gc risk and phenotype in a caucasian population in spain. genomic dna from 603 patients with primary gc and 603 healthy controls was typed for 123 single nucleotide polymorphisms in dna repair genes using the illumina platform. helicobacter pylori infection ... | 2017 | 28415781 |
| helicobacter pylori infection in texas hispanic and non-hispanic white men: implications for gastric cancer risk disparities. | chronic helicobacter pylori ( h. pylori) infection is a major gastric adenocarcinoma (ga) risk factor. ga disproportionately affects u.s. hispanics compared with non-hispanic whites (nhws). since h. pylori infection studies in hispanics are few, infection rates in hispanic and nhw men in bexar county were compared, and relationships with ethnicity and obesity examined. age- and zip code-matched participants from a community-dwelling cohort were randomly selected. sera from 284 men were analyzed ... | 2017 | 28413904 |
| helicobacter pylori vaca s1m1 genotype but not caga or baba2 increase the risk of ulcer and gastric cancer in patients from southern mexico. | the vaca, caga and baba2 genotypes of helicobacter pylori are associated with gastric pathology. the objectives were to determine the frequency of infection and distribution of the vaca, caga and baba2 genotypes of h. pylori in patients with gastric ulcer, chronic gastritis and gastric cancer, and to evaluate the association of virulent genotypes with diagnosis. | 2017 | 28413454 |
| rate of active helicobacter pylori infection among symptomatic patients of pakistan. | only few epidemiological studies have examined the rate of active h. pylori infection in the symptomatic population in pakistan. this retrospective study presents the laboratory data collected during the past 13 years (2002 to 2015) from 2315 symptomatic patients referred to the breathmat lab, nuclear medicine, oncology and radiotherapy institute, islamabad for the diagnosis of active h. pylori infection using the (13)c urea breath test. rate of infection and its association with gender and age ... | 2017 | 28413207 |
| structure and function of helicobacter pylori caga, the first-identified bacterial protein involved in human cancer. | chronic infection with helicobacter pylori caga-positive strains is the strongest risk factor of gastric cancer. the caga gene-encoded caga protein is delivered into gastric epithelial cells via bacterial type iv secretion, where it undergoes tyrosine phosphorylation at the glu-pro-ile-tyr-ala (epiya) motifs. delivered caga then acts as a non-physiological scaffold/hub protein by interacting with multiple host signaling molecules, most notably the pro-oncogenic phosphatase shp2 and the polarity- ... | 2017 | 28413197 |
| mexican consensus on dyspepsia. | since the publication of the 2007 dyspepsia guidelines of the asociación mexicana de gastroenterología, there have been significant advances in the knowledge of this disease. a systematic search of the literature in pubmed (01/2007 to 06/2016) was carried out to review and update the 2007 guidelines and to provide new evidence-based recommendations. all high-quality articles in spanish and english were included. statements were formulated and voted upon using the delphi method. the level of evid ... | 2017 | 28413079 |
| no evidence to support a role for helicobacter pylori infection and plasminogen binding protein in autoimmune pancreatitis and igg4-related disease in a uk cohort. | helicobacter pylori (h.pylori) plasminogen binding protein (pbp) has been proposed as an antigen triggering autoimmune pancreatitis (aip), the pancreatic manifestation of igg4-related disease (igg4-rd). we investigated exposure to h. pylori infection, cytokine response and immunological memory to h. pylori pbp in a prospective igg4-rd cohort in the uk. | 2017 | 28412148 |
| gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (concern): an industry-independent, double-blind, double-dummy, randomised trial. | present guidelines are conflicting for patients at high risk of both cardiovascular and gastrointestinal events who continue to require non-steroidal anti-inflammatory drugs (nsaids). we hypothesised that a cyclooxygenase-2-selective nsaid plus proton-pump inhibitor is superior to a non-selective nsaid plus proton-pump inhibitor for prevention of recurrent ulcer bleeding in concomitant users of aspirin with previous ulcer bleeding. | 2017 | 28410791 |
| efficacy and safety of jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients. | jianzhong decoction is widely used to treat peptic ulcers; however, due to lack of systematic evaluations, its clinical efficacy remains controversial. we performed meta-analysis to evaluate the efficacy and safety of jianzhong decoction in treating peptic ulcers. | 2017 | 28410586 |
| correction: rapid evolution of distinct helicobacter pylori subpopulations in the americas. | [this corrects the article doi: 10.1371/journal.pgen.1006546.]. | 2017 | 28410409 |
| pathogen-associated regulatory non-coding rnas and oncogenesis. | among all new cancer cases in 2012, on average, 15.4% were caused by helicobacter pylori or oncoviruses, including epstein-barr virus, human papillomavirus, hepatitis b virus, hepatitis c viruses, kaposi sarcoma-associated herpesvirus and human t-lymphotropic virus. these pathogens encode a variety of non-coding rnas, which are important cofactors for oncogenesis. in this review, we focus on recent developments in the study of long and small non-protein-coding rnas, including micrornas, of oncog ... | 2017 | 28410134 |
| real-world helicobacter pylori diagnosis in patients referred for esophagoduodenoscopy: the gap between guidelines and clinical practice. | histopathology is the most accurate test to detect h. pylori when performed correctly with unknown validity in daily practice clinic settings. we aimed to determine the rate of potentially false-negative h. pylori results that might be due to continued use of proton pump inhibitors (ppis) in routine endoscopy practice. we also aimed to establish whether gastroenterologists recommend routine cessation of ppis before esophagogastroduodenoscopy (egd) and whether they regularly document that biopsie ... | 2016 | 28408993 |
| effectiveness of citrus fruits on helicobacter pylori. | it is known that helicobacter pylori infection is associated with chronic gastritis, peptic ulcer, and gastric carcinoma. due to the increased side effects of the treatment regimens and the development of antimicrobial resistance, a number of natural compounds have been tested as potential alternatives. in this review, we will examine the current knowledge on the effect of citrus fruits and their derivatives against h. pylori, highlighting the remaining outstanding questions on the development o ... | 2017 | 28408943 |
| draft genome sequences of 13 colombian helicobacter pylori strains isolated from pacific coast and andean residents. | we present here the draft genomes of 13 helicobacter pylori strains isolated from colombian residents on the pacific coast (n = 6) and in the andes mountains (n = 7), locations that differ in gastric cancer risk. these 13 strains were obtained from individuals with diagnosed gastric lesions. | 2017 | 28408665 |
| protective effects of helicobacter pylori for ibd are related to the caga-positive strain. | | 2017 | 28408384 |
| manuka honey (leptospermum scoparium) inhibits jack bean urease activity due to methylglyoxal and dihydroxyacetone. | manuka honey (leptospermum scoparium) exerts a strong antibacterial effect. bacterial enzymes are an important target for antibacterial compounds. the enzyme urease produces ammonia and enables bacteria to adapt to an acidic environment. a new enzymatic assay, based on photometric detection of ammonia with ninhydrin, was developed to study urease activity. methylglyoxal (mgo) and its precursor dihydroxyacetone (dha), which are naturally present in manuka honey, were identified as jack bean ureas ... | 2017 | 28407946 |
| polaprezinc combined with clarithromycin-based triple therapy for helicobacter pylori-associated gastritis: a prospective, multicenter, randomized clinical trial. | the efficacy and safety of polaprezinc combined with triple therapy was compared with triple therapy alone in the eradication of helicobacter pylori. a randomized, parallel-group, open-label, controlled, prospective multicenter study was conducted in 11 cities in china. treatment-naive patients with h. pylori-associated gastritis were randomly assigned to one of three arms for a 14-day treatment: arm a triple therapy (omeprazole 20 mg, amoxicillin 1 g, and clarithromycin 500 mg, each twice daily ... | 2017 | 28407007 |
| gastric intestinal metaplasia: an intermediate precancerous lesion in the cascade of gastric carcinogenesis. | gastric intestinal metaplasia, an intermediate lesion in the development of intestinal-type gastric cancer, is observed in the milieu of long standing non-atrophic gastritis and atrophic gastritis. most patients with intestinal metaplasia remain asymptomatic unless cobalamin deficiency occurs secondary to loss of glands (that produce intrinsic factor and acid). genetic events that predispose to development of gastric intestinal metaplasia remains an enigma. mechanisms leading to the progression ... | 2017 | 28406776 |
| association of helicobacter pylori with parkinson's disease. | parkinson's disease (pd) is a major neurological disorder that requires lifelong treatment, and the combined presence of helicobacter pylori (h. pylori) infection can increase the required anti-pd medications. we aim to investigate the effect of h. pylori infection in indian pd patients. | 2017 | 28406585 |
| sequence polymorphism and intrinsic structural disorder as related to pathobiological performance of the helicobacter pylori caga oncoprotein. | caga, an oncogenic virulence factor produced by helicobacter pylori, is causally associated with the development of gastrointestinal diseases such as chronic gastritis, peptic ulcers, and gastric cancer. upon delivery into gastric epithelial cells via bacterial type iv secretion, caga interacts with a number of host proteins through the intrinsically disordered c-terminal tail, which contains two repeatable protein-binding motifs, the glu-pro-ile-tyr-ala (epiya) motif and the caga multimerizatio ... | 2017 | 28406453 |
| dyspepsie et helicobacter pylori. | | 2017 | 28406409 |
| family history is an independent risk factor for the progression of gastric atrophy among patients with helicobacter pylori infection. | risk factors for progression of gastric atrophy have not been fully elucidated. the aim of this study was to evaluate the risk factors for the development of atrophic gastritis in patients with helicobacter pylori (h. pylori ) infection. | 2017 | 28405319 |
| interleukin 8 (-251 t>a) polymorphism in children and teenagers infected with helicobacter pylori. | helicobacter pylori (h. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. this study evaluated the correlations between the -251 (t>a) (rs4073) polymorphism of interleukin-8 (il-8), the etiology of gastric disease, and h. pylori infection in pediatric and adolescent patients. | 2017 | 28405201 |
| genetic variations of tlr5 gene interacted with helicobacter pylori infection among carcinogenesis of gastric cancer. | gastric cancer (gc) ranks the second prevalent cancer type and the second cancer-related death in china. however, the precise mechanisms of gc development remain poorly understood. chronic infection with helicobacter pylori is the strongest identified risk factor for gc. toll-like receptor (tlr) genes, which play critical roles in helicobacter pylori induced chronic inflammation, may also be implicated in gc susceptibility. tlr5 signaling deficiency could deregulate a cascade of inflammatory eve ... | 2017 | 28404962 |
| microrna-143-3p, up-regulated in h. pylori-positive gastric cancer, suppresses tumor growth, migration and invasion by directly targeting akt2. | our previous studies have suggested a protective role for h. pylori infection in the prognosis of gastric cancer. based on those findings, we hypothesized that h. pylori-positive and -negative gastric cancers may exhibit different growth patterns and pathobiological behaviors, indicating different mechanisms of cancer progression. by microarray analysis, we studied mirnas expression profiles in 42 gastric cancer patients, comparing 21 h. pylori-positive and 21 h. pylori-negative groups. lucifera ... | 2017 | 28404925 |
| helicobacter pylori: iceman and the maverick. | | 2016 | 28404195 |
| a microbiota-centric view of diseases of the upper gastrointestinal tract. | the distinctive anatomy and physiology of the upper gastrointestinal tract and the difficulty of obtaining samples led to the theory that it was bacteria free. however, multiomics studies are indicating otherwise. although influenced by both oral and gastric bacteria, the resident microbial ecosystem in the oesophagus is dominated by streptococcus. a shift from gram-positive to gram-negative bacteria occurs in oesophagitis and barrett's oesophagus, and this shift might be involved in the pathoge ... | 2017 | 28404159 |
| a non-endoscopic device to sample the oesophageal microbiota: a case-control study. | the strongest risk factor for oesophageal adenocarcinoma is reflux disease, and the rising incidence of this coincides with the eradication of helicobacter pylori, both of which might alter the oesophageal microbiota. we aimed to profile the microbiota at different stages of barrett's carcinogenesis and investigate the cytosponge as a minimally invasive tool for sampling the oesophageal microbiota. | 2017 | 28404012 |
| a prospective study of urinary prostaglandin e2 metabolite, helicobacter pylori antibodies, and gastric cancer risk. | previous studies suggest that a stable end-product of prostaglandin e2, the urinary metabolite pge-m, is associated with colorectal cancer, and 1 study of relatively small sample size found an association with gastric cancer among women. in the present study we further investigate the pge-m, helicobacter pylori, and gastric cancer association. | 2017 | 28402440 |
| sensitivity of helicobacter pylori detection by giemsa staining is poor in comparison with immunohistochemistry and fluorescent in situ hybridization and strongly depends on inflammatory activity. | conventional stainings (including h&e and special stains like giemsa) are the most widely applied histopathologic detection methods of helicobacter pylori (hp). | 2017 | 28402048 |
| survival of helicobacter pylori in gastric acidic territory. | helicobacter pylori is well adapted to colonize the epithelial surface of the human gastric mucosa and can cause persistent infections. in order to infect the gastric mucosa, it has to survive in the gastric acidic ph. this organism has well developed mechanisms to neutralize the effects of acidic ph. | 2017 | 28402047 |
| inactivation of ferric uptake regulator (fur) attenuates helicobacter pylori j99 motility by disturbing the flagellar motor switch and autoinducer-2 production. | flagellar motility of helicobacter pylori has been shown to be important for the bacteria to establish initial colonization. the ferric uptake regulator (fur) is a global regulator that has been identified in h. pylori which is involved in the processes of iron uptake and establishing colonization. however, the role of fur in h. pylori motility is still unclear. | 2017 | 28402041 |
| helicobacter pylori induced phosphatidylinositol-3-oh kinase/mtor activation increases hypoxia inducible factor-1α to promote loss of cyclin d1 and g0/g1 cell cycle arrest in human gastric cells. | helicobacter pylori (h. pylori) is a human gastric pathogen that has been linked to the development of several gastric pathologies, such as gastritis, peptic ulcer, and gastric cancer. in the gastric epithelium, the bacterium modifies many signaling pathways, resulting in contradictory responses that favor both proliferation and apoptosis. consistent with such observations, h. pylori activates routes associated with cell cycle progression and cell cycle arrest. h. pylori infection also induces t ... | 2017 | 28401064 |
| the role of endoscopic ultrasound in the diagnosis and management of primary gastric lymphoma. | endoscopic ultrasound (eus) is considered a valuable diagnostic tool during the workup of malignant gastric lesions, including primary gastric lymphomas (pgl). although endoscopy combined with multiple biopsies remains essential in the establishment of pgl diagnosis, eus utilization in locoregional disease staging has been well documented in the literature. data also support the possible role of eus in prediction of response to first-line treatment, that is, helicobacter pylori eradication. howe ... | 2017 | 28400819 |
| the helicobacter pylori j99 jhp0106 gene, under the control of the csra/rpon regulatory system, modulates flagella formation and motility. | csra has been shown to positively control the expression of flagella-related genes, including flaa and flab, through regulating expression of an alternative sigma factor rpon in helicobacter pylori j99. here, we aimed to characterize the csra regulatory system by comparative transcriptomic analysis carried out with rna-seq on strain j99 and a csra mutant. fifty-three genes in the csra mutant were found to be differentially expressed compared with the wild-type. among csra-regulated genes, jhp010 ... | 2017 | 28400753 |
| proteolysis in helicobacter pylori-induced gastric cancer. | persistent infections with the human pathogen and class-i carcinogen helicobacter pylori (h. pylori) are closely associated with the development of acute and chronic gastritis, ulceration, gastric adenocarcinoma and lymphoma of the mucosa-associated lymphoid tissue (malt) system. disruption and depolarization of the epithelium is a hallmark of h. pylori-associated disorders and requires extensive modulation of epithelial cell surface structures. hence, the complex network of controlled proteolys ... | 2017 | 28398251 |
| helicobacter pylori strains and gastric malt lymphoma. | this article summarizes the main findings concerning helicobacter pylori associated with gastric malt lymphoma (gml). considered together, gml strains based on their virulence factor profile appear to be less virulent than those associated with peptic ulcers or gastric adenocarcinoma. a particular lewis antigen profile has been identified in gml strains and could represent an alternative adaptive mechanism to escape the host immune response thereby allowing continuous antigenic stimulation of in ... | 2017 | 28397767 |
| the effect of proton pump inhibitors on the gastric mucosal microenvironment. | proton pump inhibitors (ppis) are widely applied for acid related disorders, and possess pleiotropic biological functions. the effect of ppis on the gastric mucosa, neutrophil and helicobacter pylori (h. pylori) infiltration and glandular atrophy has not been well investigated, particularly the duration of the effects of ppis. | 2017 | 28397430 |
| omeprazole absorption and fasting gastrinemia after roux-en-y gastric bypass. | roux-en-y gastric bypass (rygb) is one of the bariatric surgeries most frequently performed worldwide. since this operation may predispose to the formation of peptic ulcer of the gastrojejunal anastomosis, the use of proton pump inhibitors (ppi) is recommended during the first postoperative year. however, so far, there is no detailed knowledge about the absorption of this medication during the immediate postoperative period and consequently about its effectiveness in blocking acid secretion. the ... | 2017 | 28397104 |
| is dna methylation the new guardian of the genome? | it has been known for more than 100 years that aneuploidy is an essence of cancer. the question is what keeps the genome stable, thereby preventing aneuploidy. for the past 25 years, it has been proposed that p53 is the "guardian of the genome." however, it has been shown that inactivation of p53 does not cause aneuploidy. another essence of cancer is global dna hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. yet, another essence of cancer is excessive use ... | 2017 | 28396696 |
| postoperative helicobacter pylori infection as a prognostic factor for gastric cancer patients after curative resection. | few studies have evaluated the effect of helicobacter pylori infection on the prognosis of patients diagnosed with gastric cancer (gc) after curative surgery. we investigated the association between the h. pylori infection status and clinical outcome after surgery. | 2017 | 28395509 |
| characteristics of primary and metachronous gastric cancers discovered after helicobacter pylori eradication: a multicenter propensity score-matched study. | gastric cancers develop even after successful helicobacter pylori eradication. we aimed to clarify the characteristics of early gastric cancers discovered after h. pylori eradication. | 2017 | 28395508 |
| comprehensive mapping of the helicobacter pylori nikr regulon provides new insights in bacterial nickel responses. | nickel homeostasis is important for pathogenic and ureolytic bacteria, which use this metal ion as enzymatic cofactor. for example, in the human pathogen helicobacter pylori an optimal balance between nickel uptake and incorporation in metallo-enzymes is fundamental for colonization of the host. nickel is also used as cofactor to modulate dna binding of the nikr regulator, which controls transcription of genes involved in nickel trafficking or infection in many bacteria. accordingly, there is mu ... | 2017 | 28393877 |
| [possibilities for optimization of eradication therapy for helicobacter pylori infection in modern clinical practice]. | a steady decline in the effectiveness of standard eradication therapy (et) regimens for helicobacter pylori infection necessitates a search for ways of their optimization, by enhancing the efficiency of treatment protocols and by improving their safety and tolerability. the review systematizes the data available in the literature on main accessible methods for optimizing et regimens. among the optimization methods that can considerably enhance the efficiency of et regimens, one may identify thei ... | 2017 | 28393827 |
| moxifloxacin, but not metronidazole can be used in therapeutic regimens against helicobacter pylori. | | 2017 | 28391677 |
| upper gastrointestinal haemorrhage: an update. | upper gastrointestinal (gi) haemorrhage is a common cause for admission to hospital and is associated with a mortality of around 10%. prompt assessment and resuscitation are vital, as are risk stratification of the severity of bleeding, early involvement of the multidisciplinary team and timely access to endoscopy, preferably within 24 h. the majority of bleeds are due to peptic ulcers for which helicobacter pylori and non-steroidal anti-inflammatory agents are the main risk factors. although pr ... | 2016 | 28839832 |
| [use of probiotics and probiotic-based immunomodulators as adjuvant therapy for helicobacter pylori eradication]. | at present, helicobacter pylori (нр) infection is the most common chronic bacterial infection in humans, the pathogen of which colonizes approximately 50% of the world's population. hp eradication is required to control complications of hp-related diseases (gastric and duodenal ulcers). nevertheless, a number of investigations have demonstrated widespread antibacterial therapy inefficiency due to hp antibiotic resistance and patient non-compliance with treatment regimens. due to the growing need ... | 2016 | 28635890 |
| [[clinical relevance helicobacter pylori genotypes in patients with chronic pancreatitis and concomitant infections helicobacter pylori].] | currently, there is a need to study the genetic diversity of h.pylori in patients with variety of acid-related dis- eases to develop new strategies for the treatment of patients with h.pylori to predict high efficiency of treatment. | 2016 | 28614641 |
| relationship between ureb sequence diversity, urease activity and genotypic variations of different helicobacter pylori strains in patients with gastric disorders. | association of the severity of helicobacter pylori induced diseases with virulence entity of the colonized strains was proven in some studies. urease has been demonstrated as a potent virulence factor for h. pylori. the main aim of this study was investigation of the relationships of ureb sequence diversity, urease activity and virulence genotypes of different h. pylori strains with histopathological changes of gastric tissue in infected patients suffering from different gastric disorders. analy ... | 2016 | 28517916 |
| helicobacter pylori infection as a risk factor in patients suffering from food allergy and urticaria. | h. pylori infection is common worldwide. many intestinal and extra intestinal manifestations have been associated with h. pylori infection. h. pylori destruct the gastric lining which allows food allergens to get access to blood, predisposing to food allergy. previous works considered chronic urticaria as a known symptom for food allergy and a skin manifestation for h. pylori infection. the aim of this work is to provide evidence based recommendation for detecting h. pylori antigen in stool in p ... | 2016 | 28502154 |
| coronins and their role in immunological phenomena. | coronins are a large family of proteins occurring in many eukaryotes. in mammals, seven coronin genes have been identified, evidencing that coronins 1 to 6 present classic coronin structure, while coronin 7 is a tandem coronin particle, without a spiral domain, although the best characterised coronin, in terms of both structure and function, is the mammalian coronin 1. it has been proven that they are related to regulation of actin dynamics, e.g. as a result of interaction with the complex of pr ... | 2016 | 28450807 |
| | infection by helicobacter pylori affects over half of the world’s population and is a public health issue. its prevalence is significantly higher in developing countries such as brazil. it has been suggested that infection by h pylori can impact calorie intake and homeostasis. | 2015 | 28586183 |