| prognostic significance of glutathione peroxidase 2 in gastric carcinoma. | increasing evidence suggests that the glutathione peroxidase 2 may actually play important roles in tumorigenesis and progression in various human cancers such as colorectal carcinomas and lung adenocarcinomas. however, the role of glutathione peroxidase 2 in gastric carcinoma remains to be determined. in this study, the expression and prognostic significance of glutathione peroxidase 2 in gastric carcinoma were investigated and the well-known prognostic factor ki-67 labeling index was also asse ... | 2017 | 28631563 |
| proinflammatory follicular helper t cells promote immunoglobulin g secretion, suppress regulatory b cell development, and correlate with worse clinical outcomes in gastric cancer. | gastric cancer is one of the most common and aggressive malignancies. both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. in this study, we investigated the potential involvement of follicular helper t cells in gastric cancer. functions of follicular helper t subsets were examined in helicobacter pylori-infected gastric cancer patients and h. pylori-infected but asymptomatic individuals. we found that the follicular helper t cells in ... | 2017 | 28631561 |
| a null model for microbial diversification. | whether prokaryotes (bacteria and archaea) are naturally organized into phenotypically and genetically cohesive units comparable to animal or plant species remains contested, frustrating attempts to estimate how many such units there might be, or to identify the ecological roles they play. analyses of gene sequences in various closely related prokaryotic groups reveal that sequence diversity is typically organized into distinct clusters, and processes such as periodic selection and extensive rec ... | 2017 | 28630293 |
| relationship between histopathological status of the helicobacter pylori infected patients and proteases of h. pylori in isolates carrying diverse virulence genotypes. | helicobacter pylori is the main cause of several gastroduodenal diseases in humans. among various virulence factors of h. pylori, proteases may also be involved in its pathogenicity. in this study, relationship between proteolytic activity of h. pylori strains and histopathological changes of the stomach was investigated in the patients infected with strains carrying diverse virulence factors. h. pylori strains were isolated from the biopsies of 116 patients who referred to hospital for their ga ... | 2017 | 28629725 |
| caga promotes proliferation and inhibits apoptosis of ges-1 cells by upregulating traf1/4-1bb. | cytotoxin-associated gene a (caga) is one of the most important virulence factors of helicobacter pylori, and serves a role in h. pylori‑mediated tumorigenesis in gastric cancer. however, the underlying molecular mechanism remains to be elucidated. the present study aimed to investigate the effects of caga on the proliferation and apoptosis of ges‑1 cells, and the underlying mechanism. a caga eukaryotic expression plasmid was constructed and transfected into ges‑1 cells. the mrna and protein lev ... | 2017 | 28627614 |
| integrative approach for the analysis of the proteome-wide response to bismuth drugs in helicobacter pylori. | bismuth drugs, despite being clinically used for decades, surprisingly remain in use and effective for the treatment of helicobacter pylori infection, even for resistant strains when co-administrated with antibiotics. however, the molecular mechanisms underlying the clinically sustained susceptibility of h. pylori to bismuth drugs remain elusive. herein, we report that integration of in-house metalloproteomics and quantitative proteomics allows comprehensive uncovering of the bismuth-associated ... | 2017 | 28626571 |
| o blood group as a risk factor for helicobacter pylori igg seropositivity among pregnant sudanese women. | the objective was to investigate the prevalence and the association between blood groups and helicobacter pylori igg seropositivity among pregnant sudanese women. a cross-sectional survey was carried-out at saad abul ela maternity hospital, khartoum, sudan during the period of july 2014 through december 2015. questionnaires covering socio-demographic and obstetrics information were administered. specific h. pylori igg antibody was analysed using elisa. one hundred eighty six pregnant women were ... | 2017 | 28626546 |
| a case of api2-malt1-positive gastric malt lymphoma with concomitant diffuse large b-cell lymphoma. | api2-malt1 translocation-positive gastric marginal zone lymphomas of mucosa-associated lymphoid tissue (malt) lymphoma is thought to transform to diffuse large b-cell lymphoma (dlbcl) rarely. a 69-year-old man presented with epigastralgia. esophagogastroduodenoscopy showed multiple ulcerations in the stomach. endoscopic biopsies revealed malt lymphoma, with helicobacter pylori infection. the patient underwent eradication therapy with no improvement, and was thereafter followed without additional ... | 2017 | 28626260 |
| the leukocyte-associated immunoglobulin (ig)-like receptor-1 modulating cell apoptosis and inflammatory cytokines secretion in thp-1 cells after helicobacter pylori infection. | helicobacter pylori is a gram-negative, microaerophilic bacteria usually found in the stomach, which may evade its host's immune system and present long-term symptoms in affected individuals. this study aimed to evaluate the functional role of leukocyte-associated immunoglobulin (ig)-like receptor-1 (lair-1) in the strategies and underlying molecular mechanisms by which h. pylori escapes the host's immune responses. | 2017 | 28625823 |
| membrane-bound atp-dependent energy systems, as extra- and intracellular key signals for gastrointestinal functions and their regulations in the gastrointestinal mucosa. | our research group has carried out various biochemical examinations in rat gastric ulcer models and in human gastrointestinal resecates obtained from patient who underwent gastric intervention due to peptic ulcer disease. biochemical methods gave excellent possibility to approach the biochemical events taking place in tissues, cellular and subcellular regulatory levels during of ulcer development and of its prevetions. this paper gives a briefsummary of these biochemical examinations conducted d ... | 2017 | 28625138 |
| practical considerations for managing helicobacter pylori in college health. | | 2017 | 28622096 |
| comparative analysis of selected cagpai genes and different vaca genotypes in iranian and turkish h. pylori-positive patients suffering from gastric adenocarcinoma and active chronic gastritis. | helicobacter pylori is a pathogen that colonizes a majority of the world's population. genetic diversity within the virulence genes of bacteria such as cagpai and vaca may have a modified effect on the pathogenic potential of the bacteria. this study aimed to investigate which genes can be suggested as potentially related virulence factors for h. pylori-associated active chronic gastritis and stomach adenocarcinoma in the northwest of iran and south of turkey. | 2017 | 28618744 |
| eradication rates in italian subjects heterogeneously managed for helicobacter pylori infection. time to abandon empiric treatments in southern europe. | h. pylori eradication is strongly affected by various factors, including the ongoing antibiotic resistance. we describe a "real life" scenario in patients managed for h. pylori-related conditions, living in a southern italian region (apulia), an area with clarithromycin resistance >15%. | 2017 | 28617882 |
| a real life study of helicobacter pylori eradication with bismuth quadruple therapy in naïve and previously treated patients. | to evaluate the efficacy and safety of a quadruple regimen (bmto) of the "3-in-1 capsule" (containing bismuth subcitrate potassium, metronidazole and tetracycline) plus omeprazole in naïve and previously treated patients diagnosed with helicobacter pylori (h. pylori) infection in the clinical setting in seville (spain). | 2017 | 28617030 |
| current approaches to gastric cancer in peru and mexico. | in peru, the incidence of gastric cancer is reported to be around 15.8 per 100,000 inhabitants and it is the second most common oncological disease in men and the third one in women. additionally, a high mortality index was reported, especially among poor people. to address this issue, in 2008, peru initiated several insurance treatment plans of oncological diseases with promising results. in mexico, there is a high predominance of gastric cancer in male gender compared to female gender, even re ... | 2017 | 28616610 |
| helicobacter pylori infection: old and new. | helicobacter pylori is a spiral-shaped bacterium that grows in the digestive tract and may be present in more than half of the world's population. the clinical features of helicobacter pylori range from asymptomatic gastritis to gastrointestinal malignancy. mucosa-associated lymphoid tissue (malt) lymphoma is a low-grade b-cell marginal zone lymphoma and helicobacter pylori has been detected in more than 75% of the patients with malt lymphoma. many tests for the detection of helicobacter pylori ... | 2017 | 28616085 |
| outer membrane phospholipase a's roles in helicobacter pylori acid adaptation. | the ph of the human gastric mucosa varies around 2.5 so that only bacteria with strong acidic stress tolerance can colonize it. the ulcer causing helicobacter pylori thrives in the gastric mucosa. we analyse the roles of the key outer membrane protein ompla in its roles in acid tolerance. | 2017 | 28616083 |
| coronin 1a, a novel player in integrin biology, controls neutrophil trafficking in innate immunity. | trafficking of polymorphonuclear neutrophils (pmns) during inflammation critically depends on the β2 integrins lymphocyte function-associated antigen 1 (lfa-1) (cd11a/cd18) and macrophage-1 antigen (cd11b/cd18). here, we identify coronin 1a (coro1a) as a novel regulator of β2 integrins that interacts with the cytoplasmic tail of cd18 and is crucial for induction of pmn adhesion and postadhesion events, including adhesion strengthening, spreading, and migration under flow conditions. transition o ... | 2017 | 28615221 |
| global patterns and trends in stomach cancer incidence: age, period and birth cohort analysis. | the cases of stomach cancer (sc) incidence are increasing per year and the sc burden has remained very high in some countries. we aimed to evaluate the global geographical variation in sc incidence and temporal trends from 1978 to 2007, with an emphasis on the effect of birth cohort. joinpoint regression and age-period-cohort model were applied. from 2003 to 2007, male rate were 1.5- to 3-fold higher than female in all countries. rates were highest in eastern asian and south american countries. ... | 2017 | 28614909 |
| contribution of matrix metalloproteinases-1 genotypes to gastric cancer susceptibility in taiwan. | expression of matrix metalloproteinase-1 (mmp1), an interstitial collagenase regulating the extracellular matrix, plays a major role in carcinogenesis of gastric cancer, a leading cause of death worldwide. in literature, the single-nucleotide polymorphism (snp) promoter -1607 1g/2g (rs1799750) at the mmp1 gene promoter has been reported to alter its own transcription level. while the importance's of the genotype of mmp1 promoter -1607 has not yet been studied in gastric cancer in taiwan, our aim ... | 2017 | 28612708 |
| helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in spain. | background: several studies have suggested that helicobacter pylori (h. pylori) infection is a risk factor for colorectal cancer (crc), while others have not confirmed this hypothesis. this work aimed to assess the relation of crc with h. pylori seropositivity and with seropositivity to 16 h. pylori proteins, in the multicase-control study, mcc-spain. methods: mcc-spain is a multicase-control study carried out in spain from 2008 to 2013. in total, 2,140 histologically-confirmed incident crc case ... | 2017 | 28611733 |
| effect of co2 on peroxynitrite-mediated bacteria killing: response to tsikas et al. | | 2017 | 28610877 |
| effects of community screening for helicobacter pylori: 13-year follow-up evaluation of a randomized controlled trial (hep-fyn). | helicobacter pylori eradication improves the prognosis of peptic ulcer disease (pud), dyspepsia, and possibly gastric cancer. h pylori screening tests are accurate and eradication therapy is effective. h pylori population screening seems attractive. the aim of this study was to evaluate the long-term effect of h pylori population screening and eradication on dyspepsia prevalence and the incidence of pud, and as secondary outcomes to assess the effect on health care consumption and quality of lif ... | 2017 | 28606845 |
| [clinical effects of different therapeutic regimens for helicobacter pylori infection in children]. | to investigate the clinical effects of sequential therapy, triple therapy, sequential therapy combined with lactobacillus, and triple therapy combined with lactobacillus in the eradication of helicobacter pylori (h.pylori) infection in children. | 2017 | 28606235 |
| high frequency of hopq genotypes among iranian helicobacter pylori clinical isolates. | different virulence factors are involved in helicobacter pylori pathogenesis. h. pylori outer membrane proteins are a family of virulence factors that have diverse members. hopq (h. pylori outer membrane protein) is the largest of them that contains types i and ii alleles. the role of hopq is not exactly known, but it has been considered in h. pylori adhesion and colonization. the aim of this study was to determine the frequency of hopq genotypes among h. pylori isolates obtained from patients w ... | 2017 | 28603230 |
| antibacterial activity of propolis extracts from the south of portugal. | to examine the antibacterial activity of diverse extracts of propolis harvested at winter and spring from several locations of algarve, portugal, against gram-negative and gram-positive bacteria was the main goal of the present work. for such, the antibacterial activity was determined by agar diffusion. the results showed that all tested bacterial strains showed susceptibility to diluted propolis extracts and in a dose-dependent manner. two propolis samples collected at springtime showed higher ... | 2017 | 28603105 |
| effectiveness of gastric cancer screening on gastric cancer incidence and mortality in a community-based prospective cohort. | this study was performed to investigate the effectiveness of gc screening methods in a community-based prospective cohort of the korean multi-center cancer cohort (kmcc) with over a 10-year follow-up. | 2017 | 28602053 |
| therapeutic success with bismuth-containing sequential and quadruple regimens in helicobacter pylori eradication. | the success rate of helicobacter pylori (h. pylori) eradication with the classical triple therapy is gradually declining. in this study, we aimed to compare and assess the efficacies of six different eradication regimens including sequential protocols. | 2017 | 28601610 |
| detection of helicobacter pylori in the gastric mucosa by fluorescence in vivo hybridization. | in this chapter, we describe a fluorescence in vivo hybridization (fivh) protocol, using nucleic acid probes, for the detection of the bacterium helicobacter pylori in the gastric mucosa of an infected c57bl/6 mouse model. this protocol should be easily extended to other microorganisms not only as a way to identify in vivo important microorganisms and their patterns of distribution within specific or at different anatomic sites, but also to better understand interaction mechanisms involving the ... | 2017 | 28600766 |
| detection of helicobacter pylori dna in formalin-fixed paraffin-embedded gastric biopsies using laser microdissection and qpcr. | molecular detection and analysis of virulence factors of helicobacter pylori depends on the specificity of cell selection in the gastric biopsies. the laser microdissection (lm) instruments combine microscopy with laser cut sectioning. this combination allows one to choose only the bacteria that are in direct contact with epithelial cells in the gastric biopsy sample, avoiding those microorganisms attached to the mucus layer in the sample. the average concentration of dna isolated from 25 cuts w ... | 2017 | 28600762 |
| buffered romanowsky-giemsa method for formalin fixed, paraffin embedded sections: taming a traditional stain. | romanowsky-giemsa (rg) stains were devised during the 19th century for identifying plasmodia parasites in blood smears. later, rg stains became standard procedures for hematology and cytology. numerous attempts have been made to apply rg staining to formalin-fixed paraffin-embedded tissue sections, with varied success. most published work on this topic described rg staining methods in which sections were overstained, then subjected to acid differentiation; unfortunately, the differentiation step ... | 2017 | 28598683 |
| determinants of the regulation of helicobacter pylori adhesins include repeat sequences in both promoter and coding regions as well as the two-component system arsrs. | we investigated the transcription of adhesin-encoding genes saba, hopz and laba in helicobacter pylori strain j99. each possesses a repeating homopolymeric nucleotide tract within their promoter regions, and saba and hopz possess repeats within their 5' coding regions. | 2017 | 28598306 |
| association of helicobacter pylori infection with parkinson's diseases: a meta-analysis. | the results from observational studies on the relationship between helicobacter pylori (h. pylori) infection and parkinson's disease remain controversial. a meta-analysis was conducted to evaluate the association between helicobacter pylori infection and parkinson's disease. | 2017 | 28598012 |
| clinical usefulness of the vs classification system using magnifying endoscopy with blue laser imaging for early gastric cancer. | blue laser imaging (bli) enables the acquisition of more information from tumors' surfaces compared with white light imaging. few reports confirm the validity of magnifying endoscopy (me) with bli (me-bli) for early gastric cancer (egc). we aimed to assess the detailed endoscopic findings from egcs using me-bli. | 2017 | 28596787 |
| high serum pepsinogen i and beta helicobacter pylori infection are risk factors for aspirin-induced gastroduodenal injury. | whether gastric hyperchlorhydria and helicobacter pylori infection contribute to aspirin-induced gastroduodenal injury still lacks evidence. because serum pepsinogens (pgs) and gastrin-17 (g17) can reflect gastric acid secretion, this study intended to elucidate whether serum pgs, serum g17, and h. pylori infection are associated with aspirin-induced gastrointestinal injury. | 2017 | 28595197 |
| rare gastric lesions associated with helicobacter pylori infection: a histopathological review. | helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. however, some rare gastric lesions exhibiting distinctive histological features may also be associated with h. pylori infection, including lymphocytic gastritis, granulomatous gastritis, russell body gastritis, or crystal-storing histiocytosis. although diverse factors can contribute to their development, there is convincing evidence th ... | 2017 | 28592787 |
| agreement between different pathologists in histopathologic diagnosis of 128 gastric polyps. | - gastric polyps are elevated mucosal lesions. most of them are less than 1 cm and when larger than 2 cm, has a high malignancy probability. the histopathological types are mainly fundic gland polyps, hyperplastic polyps and adenomatous polyps. | 2017 | 28591245 |
| increased risk for metachronous gastric adenocarcinoma following gastric malt lymphoma-a us population-based study. | gastric mucosa-associated lymphoid tissue lymphoma (gmalt) and gastric adenocarcinoma (gc) are long-term complications of chronic helicobacter pylori (hp) gastritis. treatment of hp infection induces remission in most patients with gmalt. endoscopic follow-up is not currently endorsed after complete remission. however, the risk of gc in these patients is unclear. | 2017 | 28588876 |
| aberrant expression of aid and aid activators of nf-κb and pax5 is irrelevant to ebv-associated gastric cancers, but is associated with carcinogenesis in certain ebv-non-associated gastric cancers. | epstein-barr virus-associated gastric carcinoma (ebvagc) is a distinct subtype of gastric cancer characterized by clinicopathological features including lymphoepithelioma-like histology. aberrant expression of activation-induced cytidine deaminase (aid) as a genomic modulator was demonstrated through pathogen-related nuclear factor κb (nf-κb) signaling in helicobacter pylori-associated gastric cancer. to elucidate whether or not aid expression is relevant to carcinogenesis in ebvagc, immunohisto ... | 2017 | 28588701 |
| helicobacter pylori stool antigen assay in hyperemesis gravidarum. | hyperemesis gravidarum is the most severe form of nausea and vomiting in pregnancy that seriously affects the pregnancy outcome. it is a disease with unknown etiology and varieties of contributing factors like hormonal changes, psychological and immunological factors. a significantly high prevalence of helicobacter pylori among pregnant women with hyperemesis gravidarum has been revealed recently. a descriptive, cross-sectional study was carried out at antenatal ward, department of obstetrics an ... | 2017 | 28588158 |
| alteration of stomach microbiota compositions in the progression of gastritis induces nitric oxide in gastric cell. | atrophic gastritis is considered to be an antecedent to intestinal metaplasia and gastric cancer. a previous study identified that helicobacter pylori was absent at the severe atrophic gastritis stage, and alterations in the gastric microbial composition resembled those in gastric cancer. to explore the role of the bacteria absence of h. pylori in gastric carcinogenesis, in the current study, we compared the microbiota of clinically collected h. pylori-free gastric fluids from 30 patients with n ... | 2017 | 28587343 |
| current status of helicobacter pylori association with haematological and cardiovascular diseases: a mini review. | helicobacter pylori infection is considered the most commonly prevalent gastrointestinal pathogen where it manages to survive despite the hostile environment of human stomach, leading to various gastric diseases including gastric cancer. due to the chronic inflammatory state induced by h. pylori and its interaction with host immune system have diverted researchers to investigate its correlation with systemic diseases outside of the gastrointestinal tract. this literature review was done to explo ... | 2017 | 28585591 |
| the increasing prevalence of hiv/helicobacter pylori co-infection over time, along with the evolution of antiretroviral therapy (art). | helicobacter pylori (h. pylori) is one of the most common human bacterial infections with prevalence rates between 10-80% depending upon geographical location, age and socioeconomic status. h. pylori is commonly found in patients complaining of dyspepsia and is a common cause of gastritis. during the course of their infection, people living with hiv (plhiv) often have a variety of gastrointestinal symptoms including dyspepsia and while previous studies have reported hiv and h. pylori co-infectio ... | 2017 | 28584718 |
| effects of patient age and choice of antisecretory agent on success of eradication therapy for helicobacter pylori infection. | the effects of patient age on the efficacy of eradication treatment for helicobacter pylori (h. pylori) remain unclear. the present study aimed to determine whether age affects eradication therapy involving vonoprazan, a novel potassium-competitive acid blocker (pcab). we reviewed the cases of 3,261 patients who were administered first-line and second-line h. pylori eradication therapy at toyoshima endoscopy clinic. the first-line treatment was clarithromycin and amoxicillin combined with a prot ... | 2017 | 28584402 |
| structural influences on the activity of bismuth(iii) indole-carboxylato complexes towards helicobacter pylori and leishmania. | seven new bismuth(iii) complexes derived from indole-carboxylic acids have been synthesised: five are homoleptic; [bi(iaa)3] b1, [bi(ipa)3] b2, [bi(iba)3] b3, [bi(mica)3] b4, [bi(iga)3] b6, and two are heteroleptic [biph(mica)2] b5 (where iaa-h=2-(1h-indol-3-yl)acetic acid, ipa-h=3-(1h-indol-3-yl)propanoic acid, iba-h=4-(1h-indol-3-yl)butanoic acid, iga-h=2-(1h-indol-3-yl)-2-oxoacetic acid, and mica-h=1-methyl-1h-indole-3-carboxylic acid). all complexes were fully characterised by elemental anal ... | 2017 | 28583712 |
| the study of h. pylori putative candidate factors for single- and multi-component vaccine development. | helicobacter pylori has grown to colonize inside the stomach of nearly half of the world's population, turning into the most prevalent infections in the universe. medical care failures noticeably confirm the need for a vaccine to hinder or deal with h. pylori. this review is planned to discuss the most known factors as a vaccine candidate, including single (ahpc, bg, caga, kata, fla, hsp, hwc, lpp, lps, nap, omp, omv, sod, tpx, urease, vaca) and multi-component vaccines. many promising results i ... | 2017 | 28581361 |
| helicobacter pylori antigens inducing early immune response in infants. | to identify the helicobacter pylori antigens operating during early infection in sera from infected infants using proteomics and immunoblot analysis. two-dimensional (2d) large and small gel electrophoresis was performed using h. pylori strain 51. we performed 2d immunoglobulin g (igg), immunoglobulin a (iga), and immunoglobulin m (igm) antibody immunoblotting using small gels on sera collected at the gyeongsang national university hospital from 4-11-month-old infants confirmed with h. pylori in ... | 2017 | 28581271 |
| helicobacter pylori, its urease and carbonic anhydrases, and macrophage nitric oxide synthase. | | 2017 | 28579469 |
| the protective role of helicobacter pylori neutrophil-activating protein in childhood asthma. | helicobacter pylori quantity and hp-nap gene expression were evaluated in the faeces of healthy and asthmatic children. | 2017 | 28579087 |
| histo-blood group carbohydrates as facilitators for infection by helicobacter pylori. | helicobacter pylori infect millions of people around the world. it occupies a niche in the human gastrointestinal tract characterized by high expression of a repertoire of carbohydrates. abo and lewis histo-blood group systems are controlled by genes coding for functional glycosyltransferases which synthesize great diversity of related fucosylated carbohydrate in different tissues, including gastrointestinal mucosa, and exocrine secretions. the structural diversity of histo-blood group carbohydr ... | 2017 | 28577915 |
| the troublesome epidemiology of barrett's esophagus and esophageal adenocarcinoma. | barrett's esophagus and esophageal adenocarcinoma diagnoses have increased markedly in recent decades. recent research with patients diagnosed with barrett's esophagus (the only known precursor for esophageal adenocarcinoma) and esophageal adenocarcinoma has identified several modifiable and nonmodifiable potential risk factors. consistent risk factors for both disorders include increasing age, male sex, white non-hispanic race/ethnicity, gastroesophageal reflux disease, lack of infection with h ... | 2017 | 28577761 |
| human infectious diseases and risk of preeclampsia: an updated review of the literature. | preeclampsia (pe) is one of the major causes of maternal and perinatal morbidity and mortality, especially in low- and middle-income countries. in recent years, a growing body of literatures suggests that infections by bacteria, viruses, and parasites and their related inflammations play an important role in the pathogenesis of pe. | 2017 | 28577241 |
| effect of cyp2c19 gene polymorphisms on proton pump inhibitor, amoxicillin, and levofloxacin triple therapy for eradication of helicobacter pylori. | background the effects of ppi are variable owing to the cyp2c19 polymorphisms. however, whether the polymorphisms could affect the hp eradication efficacy of triple therapy is still not clear. the present study aimed to assess the effects of cyp2c19 gene polymorphisms on proton pump inhibitor (ppi), amoxicillin, and levofloxacin triple therapy for helicobacter pylori (hp) eradication. material and methods we randomly assigned 160 hp-positive patients with chronic gastritis to 2 groups to receive ... | 2017 | 28577017 |
| the contribution of clinical and pathological predisposing factors to severe gastro-duodenal lesions in patients with long-term low-dose aspirin and proton pump inhibitor therapy. | preventive strategies developed to avoid the complications of antiplatelet therapies recommend the evaluation of risk factors for gastrointestinal events and indicated gastroprotective strategies. | 2017 | 28576397 |
| spectroscopic characterization and fluorescence imaging of helicobacter pylori endogenous porphyrins. | conventional antimicrobial strategies have become increasingly ineffective due to the rapid emergence of antibiotic resistance among pathogenic bacteria. in order to overcome this problem, antimicrobial photodynamic therapy (pdt) is considered a promising alternative therapy. pdt has a broad spectrum of action and low mutagenic potential. it is particularly effective when microorganisms present endogenous photosensitizing pigments. helicobacter pylori (hp), a pathogen notoriously responsible of ... | 2017 | 28576278 |
| helicobacter pylori eradication with levofloxacin or clarithromycin in dialysis versus nonuremic patients. | various medication regimens have been used to eradicate helicobacter pylori in dialysis patients; however, optimal response to treatment is still a challenge. this study aimed to compare response to h pylori eradication in dialysis and nonuremic patients. | 2017 | 28575885 |
| utility of normalized genome quantification of helicobacter pylori in gastric mucosa using an in-house real-time polymerase chain reaction. | traditional diagnostic assays for helicobacter pylori detection have their limitations. molecular methods can improve both diagnosis and understanding of gastric diseases. here we describe an in-house quantitative real-time polymerase chain reaction (q-rt-pcr) for the detection of h. pylori in gastric biopsies which has been developed and has a detection limit of 10 copies, the specificity of which was tested against other gastric colonizer bacteria. in this study, 199 gastric biopsies from adul ... | 2017 | 28575047 |
| association of heterogenicity of helicobacter pylori cag pathogenicity island with peptic ulcer diseases and gastric cancer. | to investigate the frequency and integrity of certain cag pathogenicity island genes (cagpai) in helicobacter pylori strains and their association with peptic ulcer disease (pud) and gastric cancer. | 2017 | 28571523 |
| serological evaluation of gastric cancer risk based on pepsinogen and helicobacter pylori antibody: relationship to endoscopic findings. | the serological risk-prediction system combined the pepsinogen (pg) test, and anti-helicobacter pylori antibody is available for evaluation of gastric cancer risk. in this system, chronic atrophic gastritis (cag) or h. pylori infection is diagnosed. subjects with h. pylori negative and pg test negative (group a) are supposed to be those who have never been infected with h. pylori and are at extremely low risk for gastric cancer. however, a certain proportion of patients with cag has been identif ... | 2017 | 28571035 |
| expression, purification, and antimicrobial activity of s100a12. | calgranulin proteins are important mediators of innate immunity and are members of the s100 class of the ef-hand family of calcium binding proteins. some s100 proteins have the capacity to bind transition metals with high affinity and effectively sequester them away from invading microbial pathogens in a process that is termed "nutritional immunity". s100a12 (en-rage) binds both zinc and copper and is highly abundant in innate immune cells such as macrophages and neutrophils. we report a refined ... | 2017 | 28570542 |
| gastric adenocarcinoma. | gastric cancers, with gastric adenocarcinoma (gac) as the most common histological type, impose a considerable global health burden. although the screening strategies for early detection have been shown to be successful in japan and south korea, they are either not implemented or not feasible in most of the world, leading to late diagnosis in most patients. helicobacter pylori infection contributes to the development of many endemic gacs, and pre-emptive eradication or early treatment of this ba ... | 2017 | 28569272 |
| antimicrobial susceptibility testing before first-line treatment for helicobacter pylori infection in patients with dual or triple antibiotic resistance. | to evaluate the efficacy of antimicrobial susceptibility-guided therapy before first-line treatment for infection in patients with dual or triple antibiotic resistance. | 2017 | 28566898 |
| the superiority of vonoprazan-based first-line triple therapy with clarithromycin: a prospective multi-center cohort study on helicobacter pylori eradication. | objective we evaluated the safety and efficacy of vonoprazan-based amoxicillin and clarithromycin 7-day triple therapy (vac) in comparison to proton pump inhibitor (ppi)-based (pac) as a first-line treatment and vonoprazan-based amoxicillin and metronidazole 7-day triple therapy (vam) in comparison to ppi-based (pam) as a second-line treatment for the eradication of helicobacter pylori in japan. methods we performed a non-randomized, multi-center, parallel-group study to compare first-line vac t ... | 2017 | 28566587 |
| effectiveness of endoscopic hemostasis with soft coagulation for non-variceal upper gastrointestinal bleeding over a 12-year period. | in this study, investigations were carried out to ascertain whether soft coagulation hemostasis for non-variceal upper gastrointestinal bleeding (ugib) has ever been performed in a time-dependent manner. | 2017 | 28564642 |
| gastric cancer in asia: unique features and management. | gastric cancer (gc) poses a burden to patients across the globe as the third leading cause of cancer deaths worldwide. incidence of gc is particularly high in asian countries, which is attributed to the prevalence of helicobacter pylori (h. pylori) infection and has prompted the establishment of unique treatment strategies. d2 gastrectomy, which was established in the 1950s in japan, has served as a gold standard for locally advanced gc for over half a century. since the beginning of the 21st ce ... | 2017 | 28561675 |
| gastric cancer in southern europe: high-risk disease. | gastric cancer is an aggressive disease. several risk factors are involved in gastric cancer pathogenesis, likely helicobacter pylori (h. pylori) infection, genetic factors in hereditary syndromes, lifestyle, and diet. however, well-implemented screening strategies are lacking in most countries, including those in southern europe. nevertheless, gastric cancer outcomes are better in some southern european countries than in others, likely because of the incidence and distribution of different hist ... | 2017 | 28561674 |
| gastrin and gastric cancer. | gastric cancer is the third leading cause of cancer-related mortality worldwide. despite progress in understanding its development, challenges with treatment remain. gastrin, a peptide hormone, is trophic for normal gastrointestinal epithelium. gastrin also has been shown to play an important role in the stimulation of growth of several gastrointestinal cancers including gastric cancer. we sought to review the role of gastrin and its pathway in gastric cancer and its potential as a therapeutic t ... | 2017 | 28560291 |
| initiation and maintenance of gastric cancer: a focus on cd44 variant isoforms and cancer stem cells. | gastric cancer is the third most common cause of cancer-related death. although the incidence of gastric cancer in the united states is relatively low, it remains significantly higher in some countries, including japan and korea. interactions between cancer stem cells and the tumor microenvironment can have a substantial impact on tumor characteristics and contribute to heterogeneity. the mechanisms responsible for maintaining malignant cancer stem cells within the tumor microenvironment in huma ... | 2017 | 28560289 |
| regulation of gastric carcinogenesis by inflammatory cytokines. | chronic inflammation caused by infection with helicobacter pylori and autoimmune gastritis increases an individual's risk of developing gastric cancer. more than 90% of gastric cancers are adenocarcinomas, which originate from epithelial cells in the chronically inflamed gastric mucosa. however, only a small subset of chronic gastritis patients develops gastric cancer, implying a role for genetic and environmental factors in cancer development. a number of dna polymorphisms that increase gastric ... | 2017 | 28560288 |
| deregulation of micrornas in gastric lymphomagenesis induced in the d3tx mouse model of helicobacter pylori infection. | helicobacter pylori infection is considered as an excellent model of chronic inflammation-induced tumor development. our project focuses on gastric malt lymphoma (gml) related to h. pylori infection and mediated by the chronic inflammatory process initiated by the infection. recently, micrornas (mirnas) have emerged as a new class of gene regulators, which play key roles in inflammation and carcinogenesis acting as oncogenes or tumor suppressors. their precise characterization in the development ... | 2017 | 28560185 |
| amoxycillin and metronidazole therapy for helicobacter pylori eradication: a 10-year trend in turin, italy. | | 2017 | 28559221 |
| circulating blood levels of il-6, ifn-γ, and il-10 as potential diagnostic biomarkers in gastric cancer: a controlled study. | gastric adenocarcinoma is the third most common cause of cancer-associated death worldwide. helicobacter pylori infection activates a signaling cascade that induces production of cytokines and chemokines involved in the chronic inflammatory response that drives carcinogenesis. we evaluated circulating cytokines and chemokines as potential diagnostic biomarkers for gastric cancer. | 2017 | 28558708 |
| azithromycin and risk of copd exacerbations in patients with and without helicobacter pylori. | helicobacter pylori (hp) infection is associated with reduced lung function and systemic inflammation in chronic obstructive pulmonary disease (copd) patients. azithromycin (az) is active against hp and reduces the risk of copd exacerbation. we determined whether hp infection status modifies the effects of az in copd patients. | 2017 | 28558695 |
| combination of helicobacter pylori infection and the interleukin 8 -251 t > a polymorphism, but not the mannose-binding lectin 2 codon 54 g > a polymorphism, might be a risk factor of gastric cancer. | mannose-binding lectin (mbl) acts in the innate immune response to helicobacter pylori. interleukin 8 (il-8) is a potent cytokine produced by gastric epithelial cells in response to h. pylori. we aimed to investigate whether polymorphisms in mbl2 and il-8 influence susceptibility to h. pylori infection, and the associations of these polymorphisms with the risk of gastroduodenal diseases in a korean population. | 2017 | 28558668 |
| morphologic characterization of residual dna methylation in the gastric mucosa after helicobacter pylori eradication. | residual dna methylation in the gastric mucosa after helicobacter pylori (h. pylori) eradication may have a role in gastric carcinogenesis. we examined the association between morphologic features and promoter methylation status of non-neoplastic gastric mucosa especially after h. pylori eradication. a total of 140 gastric specimens from 99 participants who had at least 6 months of post-eradication period were examined. the magnifying narrow-band imaging (nbi) endoscopic feature of gastric mucos ... | 2017 | 28557342 |
| helicobacter pylori from peptic ulcer patients in uganda is highly resistant to clarithromycin and fluoroquinolones: results of the genotype helicodr test directly applied on stool. | around 70-90% of peptic ulcer disease (pud) is due to helicobacter pylori and requires treatment with antimicrobials to which these bacteria are susceptible. common h. pylori diagnostic tests do not provide drug susceptibility data. using the genotype helicodr pcr test designed for gastric biopsies for simultaneous detection of h. pylori and its resistance to clarithromycin (cla)/fluoroquinolones (flq), we present evidence for stool as an optional test specimen and also provide data on prevalenc ... | 2017 | 28555193 |
| effects of anti-helicobacter pylori concomitant therapy and probiotic supplementation on the throat and gut microbiota in humans. | the microbiota within humans maintains homeostasis and plays important roles in human health. however, some situations such as the use of antibiotics may disrupt the microbiota balance and result in a series of adverse effects. this study aimed to investigate the effects of a commonly used anti-helicobacter pylori concomitant therapy on the composition of the gut and throat microbiota and any antibiotic resistance that may develop. in addition to the standard regimen, two different supplementary ... | 2017 | 28552806 |
| probiotics in helicobacter pylori eradication therapy: systematic review and network meta-analysis. | several probiotics were effective in the eradication treatment for helicobacter pylori (hp), but their comparative efficacy was unknown. | 2017 | 28552432 |
| randomized controlled trial for helicobacter pylori eradication in a naive portuguese population: is sequential treatment superior to triple therapy in real world clinical setting? | helicobacter pylori eradication has become increasingly difficult as resistances to several antibiotics develop. we aimed to compare helicobacter pylori eradication rates between triple therapy and sequential therapy in a naive portuguese population. | 2017 | 28550827 |
| intracellular delivery of oligonucleotides in helicobacter pylori by fusogenic liposomes in the presence of gastric mucus. | the rising antimicrobial resistance contributes to 25000 annual deaths in europe. this threat to the public health can only be tackled if novel antimicrobials are developed, combined with a more precise use of the currently available antibiotics through the implementation of fast, specific, diagnostic methods. nucleic acid mimics (nams) that are able to hybridize intracellular bacterial rna have the potential to become such a new class of antimicrobials and additionally could serve as specific d ... | 2017 | 28550752 |
| cost-effectiveness of combined serum anti-helicobacter pylori igg antibody and serum pepsinogen concentrations for screening for gastric cancer risk in japan. | a combination of assays for the presence of serum anti-helicobacter pylori igg antibody (hpa) and serum pepsinogen (pg) concentrations can be used to screen for gastric cancer risk. in japan, this "abc method" is considered an effective means of stratifying gastric cancer risk. this study aimed to ascertain its cost-effectiveness for assessing gastric cancer risk. | 2017 | 28550494 |
| demographic and socioeconomic influences on helicobacter pylori gastritis and its pre-neoplastic lesions amongst us residents. | gastric infection with helicobacter pylori (hp) can lead to chronic inactive gastritis, atrophy and intestinal metaplasia. | 2017 | 28547755 |
| pleiotropic cytotoxicity of vaca toxin in host cells and its impact on immunotherapy. | introduction: in the recent decades, a number of studies have highlighted the importance of helicobacter pylori in the initiation and development of peptic ulcer and gastric cancer. some potential virulence factors (e.g., urease, caga, vaca, baba) are exploited by this microorganism, facilitating its persistence through evading human defense mechanisms. among these toxins and enzymes, vacuolating toxin a (vaca) is of a great importance in the pathogenesis of h. pylori. vaca toxin shows different ... | 2017 | 28546954 |
| alterations in metabolic pathways in stomach of mice infected with helicobacter pylori. | numerous studies of helicobacter pylori (h. pylori) have been performed, but few studies have evaluated the effects of h. pylori infections using metabolome analysis, which involves the comprehensive study of low molecular weight metabolites. in this study, the metabolites in the stomach tissue of mice that had been infected with h. pylori ss1 for 1, 3, or 6 months were analyzed, and then evaluations of various metabolic pathways were performed to gain novel understandings of h. pylori infection ... | 2017 | 28546118 |
| outcomes of a randomized controlled trial comparing modified high dose omeprazole and amoxicillin triple therapy with standard triple therapy for helicobacter pylori eradication | background: helicobacter pylori (h. pylori) infection is related to peptic ulcer diseases and gastric cancer and eradication of h. pylori should be expected to decrease the risk of their development. factors affecting h. pylori eradication are antibiotic resistance, cyp2c19 genotypes, drug regimen and patient compliance. increment of omeprazole and amoxicillin dosage in clarithromycin-containing triple therapy regimen may overcome these problems and may be a better choice than the conventional c ... | 2017 | 28545189 |
| effect of helicobacter pylori infection on the link between glp-1 expression and motility of the gastrointestinal tract. | although helicobacter pylori (h. pylori) infection is closely associated with the development of peptic ulcer, its involvement in pathophysiology in the lower intestinal tract and gastrointestinal (gi) motility remains unclear. glucagon-like peptide-1 (glp-1) is a gut hormone produced in the lower intestinal tract and involved in gi motility. here, we investigated the effect of h. pylori infection on the link between glp-1 expression and motility of the gi tract. | 2017 | 28545056 |
| usefulness of detection of clarithromycin-resistant helicobacter pylori from fecal specimens for young adults treated with eradication therapy. | to prevent helicobacter pylori infection in the younger generation, it is necessary to investigate the prevalence of antibiotic-resistant h. pylori. | 2017 | 28544222 |
| phylogeographic agreement between prophage and bacterial housekeeping genes in helicobacter pylori strains from the gambia. | | 2017 | 28544172 |
| rosacea is associated with helicobacter pylori: a systematic review and meta-analysis. | rosacea is a common skin disease characterized by facial erythema, telangiectasia, papules and pustules. helicobacter pylori infection has been suggested to play a role in the etiopathogenesis of rosacea. | 2017 | 28543746 |
| clinical implications of pre-existing adenoma in endoscopically resected early gastric cancers. | although gastric adenoma is widely accepted as a precursor of gastric cancer, pre-existing adenoma is not always detected in gastric cancer patients. | 2017 | 28542582 |
| joint espghan/naspghan guidelines for the management of helicobacter pylori in children and adolescents (update 2016). | because of the changing epidemiology of helicobacter pylori infection and low efficacy of currently recommended therapies, an update of the european society for paediatric gastroenterology hepatology and nutrition/north american society for pediatric gastroenterology, hepatology and nutrition recommendations for the diagnosis and management of h pylori infection in children and adolescents is required. | 2017 | 28541262 |
| efficacy and safety of the triple therapy containing ilaprazole, levofloxacin, and amoxicillin as first-line treatment in helicobacter pylori infections. | background and aims. to establish the efficacy and safety of ilaprazole, levofloxacin, and amoxicillin as a first-line eradication treatment for helicobacter pylori. methods. patients with gastric ulcer, duodenal ulcer, or gastritis, as detected by esophagogastroduodenoscopy with confirmed h. pylori infection between september 2014 and november 2015, were enrolled in the study. all participants received ilaprazole (10 mg bid), levofloxacin (500 mg bid), and amoxicillin (1000 mg bid) for 10 days. ... | 2017 | 28539935 |
| the possible role of helicobacter pylori infection in non-alcoholic fatty liver disease. | helicobacter pylori (h. pylori) which colonizes the stomach can cause a wide array of gastric disorders, including chronic gastritis, peptic ulcer, and gastric cancer. recently, accumulating evidence has implicated h. pylori infection in extragastrointestinal diseases such as cardiovascular diseases, neurological disorders, and metabolic diseases. at the same time, many scholars have noted the relationship between h. pylori infection and non-alcoholic fatty liver disease (nafld). despite the pos ... | 2017 | 28539915 |
| multipathway integrated adjustment mechanism of glycyrrhiza triterpenes curing gastric ulcer in rats. | gastric ulcer is a common chronic disease in human digestive system, which is difficult to cure, easy to relapse, and endangers human health seriously. compared with western medicine, traditional chinese medicine has a unique advantage in improving the general situation, stablizing medical condition, and with little side effects. glycyrrhiza known as "king of all the medicine", has a range of pharmacological activities and is commonly used in a variety of proprietary chinese medicines and formul ... | 2017 | 28539709 |
| elevated gastric antrum erosions in portal hypertension patients: peptic disease or mucosal congestion? | portal hypertension (ph) is a syndrome characterized by chronic increase in the pressure gradient between the portal vein and inferior vena cava. previous studies have suggested an increased frequency of antral elevated erosive gastritis in patients with ph, as well as an etiologic association; however, there has not been any histological evidence of this hypothesis to date. our aim was to evaluate the histological features found in elevated antral erosions in patients with portal hypertension. | 2017 | 28539032 |
| prevalência de infecção por helicobacter pylori em uma comunidade indígena em são paulo e fatores associados: estudo transversalprevalence of helicobacter pylori infection in an indigenous community in são paulo and associated factors: cross-sectional study. | the prevalence of helicobacter pylori infection is unevenly distributed among different populations. the aim here was to evaluate the factors associated with helicobacter pylori infection among children up to five years of age living in a high-risk community. | 2017 | 28538867 |
| molecular basis of alcohol-related gastric and colon cancer. | many meta-analysis, large cohort studies, and experimental studies suggest that chronic alcohol consumption increases the risk of gastric and colon cancer. ethanol is metabolized by alcohol dehydrogenases (adh), catalase or cytochrome p450 2e1 (cyp2e1) to acetaldehyde, which is then further oxidized to acetate by aldehyde dehydrogenase (aldh). acetaldehyde has been classified by the international agency for research on cancer (iarc) as a group 1 carcinogen to humans. the acetaldehyde level in th ... | 2017 | 28538665 |
| an overview of challenges to eradication of helicobacter pylori infection and future prospects. | the eradication of h. pylori infection continues to be a challenge due to the evolution of drug-resistant bacteria, lack of a gold standard diagnostic method, and ineffectiveness of current vaccines. additionally, there still is no consensus in the literature about the main source of gastric h. pylori infection. the bacterium has also been demonstrated to colonize in dental plaque and the oral cavity. we believe that to develop new approaches for successful eradication of the disease, factors su ... | 2017 | 28537662 |
| the diagnosis and management of h. pylori infection in singapore. | helicobacter pylori (h. pylori) is an infection that has a role in causing dyspepsia and complications such as peptic ulcer disease and gastric malignancies. in the primary care setting, one can adopt a stepwise approach with the 'test-and-treat' strategy to manage h. pylori-associated dyspepsia in young patients without alarm symptoms. empiric first-line therapies should be for a two-week duration; options include clarithromycin-containing triple therapy alone or with the addition of bismuth, c ... | 2017 | 28536725 |
| helicobacter pylori antibody responses in association with eradication outcome and recurrence: a population-based intervention trial with 7.3-year follow-up in china. | to identify serum biomarkers that may predict the short or long term outcomes of anti-helicobacter pylori (h. pylori) treatment, a follow-up study was performed based on an intervention trial in linqu county, china. | 2017 | 28536491 |