| yes, research matters. | my father was diagnosed with stomach cancer recently. luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. my father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. in his case, the diagnosis started from a suggestion by his doctor to check whether he had a gastric infection with helicobacter pylori, a bacterial species found in the digestive trac ... | 2017 | 28796840 |
| berberine containing quadruple therapy for initial helicobacter pylori eradication: an open-label randomized phase iv trial. | due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for helicobacter pylori (h pylori) eradication. however, different results are varied greatly and the availability of bismuth was limited in some countries. we assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an alternative regimen for h pylori eradication. | 2017 | 28796053 |
| helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease. | controversy exists concerning the relation between helicobacter pylori (hp) infection and coronary artery disease (cad). we aimed to examine the relationship between hp infection and severity of coronary atherosclerosis in patients with chronic cad. | 2017 | 28794636 |
| the study of memory and executive dysfunction in patients infected with helicobacter pylori. | background infectious agents are considered as potential causes of alzheimer's disease. recently, evidence of a high prevalence of helicobacter pylori (h. pylori) infection in patients with alzheimer's disease has been observed. the aim of this study was to investigate memory and executive function in h. pylori positive persons not suffering from alzheimer's or other marked cognitive disorders. methods this is a cross-sectional study. a total 140 participants were selected using purposive sampli ... | 2017 | 28791919 |
| frequency of infection with helicobacter pylori isolates of different antimicrobial profiles in children and adolescents: a preliminary study. | helicobacter pylori (h. pylori) infection can occur as a mixed infection caused by several strains of h. pylori. | 2017 | 28791844 |
| an evaluation of selected oral health indicators and cariogenic bacteria titer in patients with helicobacter pylori. | studies based on polymerase chain reaction (pcr) techniques indicate that helicobacter pylori can be constantly or temporarily present in the oral cavity in virulent or non-virulent form. streptococcus mutans exerts a strong inhibitory effect on h. pylori. | 2017 | 28791813 |
| reducing the flexibility of type ii dehydroquinase enzyme for inhibition - a fragment-based approach and molecular dynamics simulation study. | a multidisciplinary approach was used to identify and optimize a quinazolinedione-based ligand that would reduce the flexibility of the substrate-covering loop (catalytic loop) of the type ii dehydroquinase from helicobacter pylori. this enzyme, which is essential for the survival of this bacterium, is involved in the biosynthesis of the aromatic amino acids. a computer-aided fragment-based protocol (alta) was first employed to identify the aromatic fragments able to block the interface pocket t ... | 2017 | 28791799 |
| comment on "effects of helicobacter pylori treatment on rosacea: a single-arm clinical trial study". | | 2017 | 28791740 |
| comment on "effects of helicobacter pylori treatment on rosacea: a single-arm clinical trial study". | | 2017 | 28791736 |
| adding bismuth to rabeprazole-based first-line triple therapy does not improve the eradication of helicobacter pylori. | this randomized controlled study aimed to evaluate whether adding bismuth to the standard first-line triple therapy could improve the eradication rate of helicobacter pylori. a total of 162 patients with helicobacter pylori infection were randomly assigned to either the 7-day triple therapy group (rak regimen: rabeprazole 20 mg, amoxicillin 1 g, and clarithromycin 500 mg bid; n = 81) or the bismuth plus triple therapy group (n = 81). in the rbak group, bismuth subcitrate 360 mg twice daily was a ... | 2017 | 28791044 |
| functional dyspepsia with helicobacter pylori infection. | helicobacter pylori infection is commonly found worldwide. in indonesia, the prevalence of h. pylori infection is 22.1%. the bacteria are responsible for gastritis, peptic ulcer disease (pud), and gastric cancer.helicobacter pylori may also has a role in functional dyspepsia. diagnostic approach consists of noninvasive and invasive examinations. one of the invasive strategy is upper gastrointestinal (ugi) endoscopy and gastric mucosa biopsy. | 2017 | 28790233 |
| the effect of psychological stress on mucosal il-6 and helicobacter pylori activity in functional dyspepsia. | pathophysiology of functional dyspepsia remains poorly understood. many factors such as gastric motility disorder, visceral hypersensitivity, helicobacter pylori (hp) infection, psychological stress and excessive gastric acid secretion play roles in this symptom. psychological stress may promote peptic ulcer and has an effect on ulcers-associated hp. this study aimed to determine helicobacter pylori activity and expression of mucosal il-6 and their association with psychological stress. | 2017 | 28790223 |
| histological transformation from gastric mucosa-associated lymphoid tissue lymphoma to gastric diffuse large b-cell lymphoma. | this study evaluated the clinical features, treatment and prognosis in chinese patients with histological transformation (ht) from gastric mucosa-associated lymphoid tissue lymphoma to gastric diffuse large b-cell lymphoma. we reviewed the medical records of 71 patients diagnosed with ht between 2001 and 2013, retrospectively. patients had a median age of 56 years. the ratio of sex (male:female) was 1.3:1. the clinical course was often insidious, lacking specific clinical presentation. macroscop ... | 2017 | 28789445 |
| the middle fragment of helicobacter pylori caga induces actin rearrangement and triggers its own uptake into gastric epithelial cells. | cytotoxin-associated gene product a (caga) is a major virulence factor secreted by helicobacter pylori. caga activity in the gastric epithelium is associated with higher risk of gastric cancer development. bacterial type iv secretion system (t4ss)-mediated translocation of caga into the cytosol of human epithelial cells occurs via a poorly understood mechanism that requires caga interaction with the host membrane lipid phosphatidylserine (ps) and host cell receptor integrin α₅β₁. here we have ch ... | 2017 | 28788072 |
| association between infection with h. pylori and atopy in young ethiopian children: a longitudinal study. | epidemiological evidence from developed countries indicates that helicobacter pylori infection correlates with a reduced risk of atopy and allergic disorders, however limited data are available from low-income countries. | 2017 | 28787771 |
| decrease of estradiol and several lifestyle factors, but not helicobacter pylori infection, are significant risks for osteopenia in japanese females. | the primary cause of osteoporosis in women is increased bone resorption and decreased bone density associated with reduced estrogen secretion. several studies have demonstrated a relationship between helicobacter pylori infection and osteoporosis regardless of estrogen levels. this study examined the relationship between h. pylori infection and osteopenia together with estrogen levels, calcium intake, and several lifestyle factors. | 2017 | 28787719 |
| physiologic, pathophysiologic, and pharmacologic regulation of gastric acid secretion. | the present review summarizes the past year's literature, both clinical and basic science, regarding physiologic and pharmacologic regulation of gastric acid secretion in health and disease. | 2017 | 28787289 |
| gastric ulcer complications after the introduction of proton pump inhibitors into clinical routine: 20-year experience. | the aim of this study was to analyze the admissions and the management of peptic ulcer disease (pud) in a tertiary care surgical center. | 2017 | 28785572 |
| management of helicobacter pylori infection: what should the surgeon know? | infection with helicobacter pylori continues to represent a major global health care burden, and various national and international consensus reports and guidelines have aimed at tracking recent developments for their translation into an optimized clinical management. the most important 'innovation' is the definition of h. pylori gastritis as an infectious disease. this does imply the consideration of therapy of this condition even before the development of clinical manifestations including non- ... | 2017 | 28785571 |
| significance of dormant forms of helicobacter pylori in ulcerogenesis. | nearly half of the global population are carriers of helicobacter pylori (h. pylori), a gram-negative bacterium that persists in the healthy human stomach. h. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. it is well established that h. pylori infection is the main cause of chronic gastritis and peptic ulcer disease (pud). decontamination of the gastric mucosa with various antibiotics leads to h. pylori elimination and longer remi ... | 2017 | 28785141 |
| up-regulation of transient receptor potential vanilloid (trpv) and down-regulation of brain-derived neurotrophic factor (bdnf) expression in patients with functional dyspepsia (fd). | the role of immune activation in functional dyspepsia (fd) patients without previous infection is unclear. we compare the gastric and circulating brain-derived neurotropic factor (bdnf), receptor potential vanilloid type (trpv) families and various cytokines in fd patients. | 2017 | 28782273 |
| systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis. | the combination of pepsinogen, gastrin-17 and anti-h. pylori antibodies serological assays (panel test) is a non-invasive tool for the diagnosis of atrophic gastritis. however, the diagnostic reliability of this test is still uncertain. | 2017 | 28782119 |
| structure-based design of ferritin nanoparticle immunogens displaying antigenic loops of neisseria gonorrhoeae. | effective vaccines are urgently needed to combat gonorrhea, a common sexually transmitted bacterial infection, for which treatment options are diminishing due to rapid emergence of antibiotic resistance. we have used a rational approach to the development of gonorrhea vaccines, and genetically engineered nanoparticles to present antigenic peptides of neisseria gonorrhoeae, the causative agent of gonorrhea. we hypothesized that the ferritin nanocage could be used as a platform to display an order ... | 2017 | 28781959 |
| management of adult primary immune thrombocytopenia based on japanese clinical guides. | primary immune thrombocytopenia (also known as idiopathic thrombocytopenic purpura; itp) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction and impaired platelet production. the therapeutic goal of itp is not to normalize the platelet count, but to elevate the platelet count to a safe range (above 30×10(3)/µl) to minimize the risk of bleeding and to minimize the side effects of drugs such as corticosteroids and tpo receptor agonists (tpor ... | 2017 | 28781283 |
| time to change approaches to helicobacter pylori management. | | 2017 | 28781120 |
| primary antibiotic resistance in helicobacter pylori in the asia-pacific region: a systematic review and meta-analysis. | so far, a comprehensive systematic review and meta-analysis has not been done of the prevalence of primary antibiotic resistance in helicobacter pylori in the asia-pacific region. we aimed to assess the trends and regional differences in primary antibiotic resistance to h pylori in the asia-pacific region and to examine the relation between resistance and first-line eradication. | 2017 | 28781119 |
| efficacy and safety of rifaximin associated with standard triple therapy (omeprazole, clarithromycin and amoxicillin) for h. pylori eradication: a phase iv pilot clinical trial. | a progressive decrease in helicobacter pylori eradication rates has been described over the years, driving the need for new antibiotic treatments. | 2017 | 28780968 |
| the association of helicobacter pylori with choroidal and retinal nerve fiber layer thickness. | to investigate the effect of helicobacter pylori (h. pylori) infection on choroidal thickness (ct) and retinal nerve fiber layer thickness (rnflt). | 2017 | 28780617 |
| the effects of helicobacter pylori eradication on modification of metabolic syndrome parameters in patients with functional dyspepsia. | helicobactor pylori (h. pylori) have the potential role in the pathogenesis of various extra-gastric disorders such as metabolic disorders. but, it is now questioned about whether h. pylori eradication reduces or induces the risk for metabolic disorders especially in patients with dyspepsia. hence, the present study aimed to assess the effects of h. pylori eradication on criteria of metabolic syndrome. | 2017 | 28780229 |
| inflammatory bowel diseases: review of known environmental protective and risk factors involved. | inflammatory bowel diseases consisting of crohn's disease and ulcerative colitis are chronic inflammatory diseases of the gastrointestinal tract. in addition to genetic susceptibility and disturbances of the microbiome, environmental exposures forming the exposome play an important role. starting at birth, the cumulative effect of different environmental exposures combined with a predetermined genetic susceptibility is thought to cause inflammatory bowel disease. all these environmental factors ... | 2017 | 28777099 |
| editorial: replacing standard proton pump inhibitors with vonoprazan may breathe new life into triple therapy for helicobacter pylori. | | 2017 | 28776748 |
| editorial: replacing standard proton pump inhibitors with vonoprazan may breathe new life into triple therapy for helicobacter pylori-authors' reply. | | 2017 | 28776746 |
| upper gastrointestinal complications and cardiovascular/gastrointestinal risk calculator in patients with myocardial infarction treated with aspirin. | aspirin is widely used for the prevention of cardiovascular and cerebrovascular diseases for the past few years. however, much attention has been paid to the adverse effects associated with aspirin such as gastrointestinal bleeding. how to weigh the benefits and hazards? the current study aimed to assess the feasibility of a cardiovascular/gastrointestinal risk calculator, asariskcalculator, in predicting gastrointestinal events in chinese patients with myocardial infarction (mi), determining un ... | 2017 | 28776541 |
| helicobacter pylori outer inflammatory protein a (oipa) suppresses apoptosis of ags gastric cells in vitro. | outer inflammatory protein a (oipa) is an important virulence factor associated with gastric cancer and ulcer development; however, the results have not been well established and turned out to be controversial. this study aims to elucidate the role of oipa in helicobacter pylori infection using clinical strains harbouring oipa "on" and "off" motifs. proteomics analysis was performed on ags cell pre-infection and postinfection with h. pylori oipa "on" and "off" strains, using liquid chromatograph ... | 2017 | 28776327 |
| vonoprazan-based helicobacter pylori eradication therapy: time to get kompetitive? | | 2017 | 28776141 |
| vaca and caga genotypes status and antimicrobial resistance properties of helicobacter pylori strains isolated from meat products in isfahan province, iran. | although helicobacter pylori has a significant impact on the occurrence of severe clinical syndromes, its exact ways of transmission and origin have not been identified. according to the results of some previously published articles, foods with animal origins play a substantial role in the transmission of h. pylori to humans. the present investigation was carried out to study the vacuolating cytotoxin a (vaca) and cytotoxin associated gene a (caga) genotypes status and antibiotic resistance prop ... | 2017 | 28775748 |
| effect on helicobacter pylori eradication therapy against gastric cancer in japan. | in japan, there have been approximately 50 000 deaths from gastric cancer annually for over 40 years with little variation. it has been reported that most gastric cancers in japan are caused by helicobacter pylori infection. h. pylori eradication therapy was approved for patients with chronic gastritis by the japanese national health insurance scheme in february 2013 for patients with an endoscopic diagnosis of chronic gastritis is positive for h. pylori. we examined the effect on gastric cancer ... | 2017 | 28771894 |
| limited effectiveness with a 10-day bismuth-containing quadruple therapy (pylera(®) ) in third-line recue treatment for helicobacter pylori infection. a real-life multicenter study. | helicobacter pylori antibiotic resistance is an increasing problem worldwide. pylera(®) may be an option as salvage therapy. | 2017 | 28771880 |
| prevention of gastric cancer: eradication of helicobacter pylori and beyond. | although its prevalence is declining, gastric cancer remains a significant public health issue. the bacterium helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. results using a mongolian gerbil model revealed that h. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of h. pylori significantly lowered cancer incidence. furthermore, some epidemiological ... | 2017 | 28771198 |
| assessment of the underlying causes of the immune thrombocytopenia: ten years experience. | immune thrombocytopenia (itp) is an immune haematologic disorder causing platelet destruction mediated by anti-platelet antibodies. in this study we aimed to evaluate the clinical and laboratory variables of itp patients in southeast of turkey. | 2017 | 28770876 |
| overexpression of serine protease htra enhances disruption of adherens junctions, paracellular transmigration and type iv secretion of caga by helicobacter pylori. | the serine protease htra is an important factor for regulating stress responses and protein quality control in bacteria. in recent studies, we have demonstrated that the gastric pathogen helicobacter pylori can secrete htra into the extracellular environment, where it cleaves-off the ectodomain of the tumor suppressor and adherens junction protein e-cadherin on gastric epithelial cells. | 2017 | 28770008 |
| mir-30a acts as a tumor suppressor by double-targeting cox-2 and bcl9 in h. pylori gastric cancer models. | helicobacter pylori (h. pylori) is one of the most important factors that affect the development of gastric cancer, and its mechanism remains un-elucidated. our present study found that, mir-30a is crucial for regulating the growth and migration of h. pylori infected gastric cancer in vitro by targeting cox-2 and bcl9. in details, double-stranded mir-30a precursor produced two single-stranded and matured mirnas including mir-30a-3p and mir-30a-5p, which played significant biological functions in ... | 2017 | 28769030 |
| gastric inflammatory fibroid polyp that was resected after a 10-year follow-up. | | 2017 | 28768372 |
| the ameliorating effect of lactobacillus gasseri oll2716 on functional dyspepsia in helicobacter pylori-uninfected individuals: a randomized controlled study. | probiotics appear to improve helicobacter pylori-associated dyspepsia via an inhibitory effect on h. pylori; however, uncertainty exists regarding their effects in h. pylori-uninfected individuals. we evaluated the efficacy of lactobacillus gasseri oll2716 (l. gasseri oll2716) on h. pylori-uninfected individuals with functional dyspepsia (fd). | 2017 | 28768250 |
| helicobacter pylori vaca genotype is a predominant determinant of immune response to helicobacter pylori caga. | to evaluate the frequency of helicobacter pylori (h. pylori) caga antibodies in h. pylori infected subjects and to identify potential histopathological and bacterial factors related to h. pylori caga-immune response. | 2017 | 28765692 |
| histomorphological spectrum of duodenal pathology in functional dyspepsia patients. | functional dyspepsia (fd) is one of the most common causes of gastrointestinal symptoms aetiology of which is poorly understood. | 2017 | 28764169 |
| chemical characterization, toxicology and mechanism of gastric antiulcer action of essential oil from gallesia integrifolia (spreng.) harms in the in vitro and in vivo experimental models. | gallesia integrifolia is a brazilian amazon tree whose bark decoction is popularly used to treat peptic ulcer. the essential oil from the inner stem bark of g. integrifolia (eogi) was chemically characterized by gc/ms. the in vitro cytotoxicity and genotoxicity were evaluated in cho-k1 cells, while the in vivo oral acute toxicity was performed in mice. the gastroprotective effect of eogi was assessed in acidified ethanol and piroxicam and ulcer healing on acetic acid -induced ulcer models in rod ... | 2017 | 28763752 |
| metal binding properties of the n-terminus of the functional amyloid orb2. | the cytoplasmic polyadenylation element binding protein (cpeb) homologue orb2 is a functional amyloid that plays a key regulatory role for long-term memory in drosophila. orb2 has a glutamine, histidine-rich (q/h-rich) domain that resembles the q/h-rich, metal binding domain of the hpn-like protein (hpnl) found in helicobacter pylori. in the present study, we used chromatography and isothermal titration calorimetry (itc) to show that the q/h-rich domain of orb2 binds ni(2+) and other transition ... | 2017 | 28763009 |
| h. pylori management in asean: the bangkok consensus report. | helicobacter pylori (h. pylori) infection remains to be the major cause of important upper gastrointestinal diseases such as chronic gastritis, peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue (malt) lymphoma. h. pylori management in asean: the bangkok consensus report gathered key opinion leaders for the region to review and evaluate clinical aspects of h. pylori infection and to develop consensus statements, rationales and grades of recommendation for the management o ... | 2017 | 28762251 |
| impact of health insurance coverage for helicobacter pylori gastritis on the trends in eradication therapy in japan: retrospective observational study and simulation study based on real-world data. | to explore the prevalence of helicobacter pylori infection in japan and the trends of its eradication therapy before and after the changes of the insurance coverage policy, first started in 2000, and expanded to cover h. pylori-positive gastritis in 2013. the impacts that the changes brought were estimated. | 2017 | 28760790 |
| a role for the tfs3 ice-encoded type iv secretion system in pro-inflammatory signalling by the helicobacter pylori ser/thr kinase, ctka. | two distinct type iv secretion systems (t4sss) can be identified in certain helicobacter pylori strains, encoded on mobile genetic elements termed tfs3 and tfs4. although their function remains unknown, both have been implicated in clinical outcomes of h. pylori infection. here we provide evidence that the tfs3 t4ss is required for activity of the pro-inflammatory ser/thr kinase protein, ctka, in a gastric epithelial cell infection model. previously, purified recombinant ctka protein has been sh ... | 2017 | 28759055 |
| anoectochilus roxburghii: a review of its phytochemistry, pharmacology, and clinical applications. | anoectochilus roxburghii (orchidaceae), also known as jinxianlian (simplified chinese: ) and jinxianlan (simplified chinese: ), is valued in many asian countries, where this plant species is used for medicinal, culinary, and ornamental purposes. as a food, a. roxburghii is widely used as a treatment booster and medicine because of its various beneficial properties; these include, most notably, the curative effects of heat dissipation and cooling of blood, elimination of dampness, detoxification, ... | 2017 | 28755972 |
| the utility of routine esophagogastroduodenoscopy before laparoscopic roux-en-y gastric bypass. | the routine use of esophagogastroduodenoscopy (egd) before laparoscopic roux-en-y gastric bypass (lrygb) is debatable. various studies have reported high diagnostic yield of routine egd before lrygb to detect pathologies that could alter surgical management. however, other studies have found that preoperative egd did not identify significant pathologies that changed clinical management; therefore, it is not indicated in asymptomatic patients. | 2017 | 28754464 |
| helicobacter pylori infection and atherosclerosis: is there a causal relationship? | for many years, the coexistence of helicobacter pylori (h. pylori) infection and atherosclerotic diseases in a disproportional number of patients has inspired the presumption that a causal relationship exists between the conditions. this presumption was evidenced by the simultaneously declining epidemics of duodenal ulcer and coronary artery diseases in the united states in the past 40 years, and was further evidenced by the detection of h. pylori and their dna in atherosclerotic plaques. sugges ... | 2017 | 28752210 |
| is duodenal biopsy appropriate in areas endemic for helicobacter pylori? | the primary reason for obtaining duodenal biopsy sample is to diagnose celiac disease. helicobacter pylori (h. pylori) and drug injury are common causes of duodenitis. the aim of this retrospective study was to explore effects of h. pylori and drugs on duodenal mucosa. | 2017 | 28752138 |
| in vitro activity of diphenyleneiodonium toward multidrug-resistant helicobacter pylori strains. | the increased resistance of helicobacter pylori to antibiotics has increased the need to develop new treatments for this bacterium. the aim of our study was to identify new drugs with anti-h. pylori activity. | 2017 | 28750485 |
| is there an association between migraine and gastrointestinal disorders? | migraine is a primary episodic headache disorder that represents a substantial burden and disability worldwide. its pathogenesis is multifactorial and remains hitherto poorly elucidated. an interesting but less-well-known association is that between migraine and gastrointestinal disorders. we have reviewed the literature for relevant papers reporting on the clinical association between migraine and gastrointestinal symptoms. several studies have shown different gastrointestinal diseases to be as ... | 2017 | 28748672 |
| rdxa, frxa and efflux pump in metronidazole-resistant helicobacter pylori: their relation to clinical outcomes. | rdxa and frxa mutations and enhancement of efflux pump have been suggested as the cause of metronidazole resistance in helicobacter pylori. this study was performed to investigate the resistance mechanisms related to clinical eradication outcome, and to examine direct involvement of hefa in metronidazole-resistant isolates with intact rdxa and frxa. | 2017 | 28748532 |
| the impact of host's genetic susceptibility on helicobacter pylori infection in children. | the aim of our study was to investigate the impact of interleukin (il)-6 190c/t, il-6 174g/c, il-6 572g/c, tumor necrosis factor-alpha (tnf-α) 308g/a, and angiotensin-converting enzyme (ace) i/d gene polymorphisms on helicobacter pylori (h. pylori) infection in children.a cross-sectional study was performed on 126 children (57 children with h. pylori infection and 69 children without h. pylori infection) aged between 3 and 18 years presenting to a pediatrics tertiary hospital from romania. child ... | 2017 | 28746216 |
| research on the mechanism of hp mediated pi3k/akt/gsk3β pathways in gastric cancer. | this study aimed to investigate the mechanism of helicobacter pylori (hp) mediated pi3k/akt/gsk3β signal pathways in the occurrence of gastric cancer. | 2017 | 28745795 |
| oxidative phosphorylation system in gastric carcinomas and gastritis. | switching of cellular energy production from oxidative phosphorylation (oxphos) by mitochondria to aerobic glycolysis occurs in many types of tumors. however, the significance of this switching for the development of gastric carcinoma and what connection it may have to helicobacter pylori infection of the gut, a primary cause of gastric cancer, are poorly understood. therefore, we investigated the expression of oxphos complexes in two types of human gastric carcinomas ("intestinal" and "diffuse" ... | 2017 | 28744336 |
| tlr5 polymorphisms rs2072493, rs5744174, and rs5744168 are not genetic risk factors for chronic helicobacter pylori infection in indian tamils. | the incidence of helicobacter pylori (h. pylori) infection and gastric cancer is on the rise in india, and the genetic factors influencing the increased susceptibility in indian population remain obscure. toll-like receptors (tlrs) play a major role in innate immune system and genetic polymorphisms affecting their function were reported to enhance the risk for h. pylori infection. seventy-seven patients (n = 77) diagnosed with h. pylori infection and 230 healthy subjects were recruited in this s ... | 2017 | 28742407 |
| interleukin-17c in human helicobacter pylori gastritis. | the interleukin-17 (il-17) family of cytokines (il-17a-f) is involved in many inflammatory diseases. although il-17a is recognized as being involved in the pathophysiology of h. pylori-associated diseases, the role of other il-17 cytokine family members remains unclear. microarray analysis of il-17 family cytokines was performed in h. pylori-infected and uninfected gastric biopsy specimens. il-17c mrna was upregulated approximately 4.5-fold in h. pylori-infected gastric biopsies. this was confir ... | 2017 | 28739826 |
| gastric cancer mortality trends in china (2006-2013) reveal increasing mortality in young subjects. | although the advent of helicobacter pylori eradication and global societal changes are widely assumed to impact on gastric cancer (gc)-related mortality, there is remarkable little quantitative and qualitative insight into the nature of its effects. here, we exploited a nationwide reporting system to investigate the epidemiological features of gc-related mortality in china between 2006 and 2013. | 2017 | 28739770 |
| antibody reactivity against helicobacter pylori proteins in a sample of the spanish adult population in 2008-2013. | differences in helicobacter pylori protein expression have been related to the risk of severe gastric diseases. in spain, a marked geographic pattern in gastric cancer mortality has long been reported. | 2017 | 28737284 |
| cytokine expression associated with helicobacter pylori and epstein-barr virus infection in gastric carcinogenesis. | helicobacter pylori and epstein-barr virus (ebv) infection, and associated cytokines are involved in gastric carcinogenesis. we investigated the expression of these cytokines and their relationship with clinicopathological characteristics. the study included specimens from 207 patients with gastric adenocarcinoma, 56 with chronic gastritis, 32 with metaplasia, and 30 with low-grade epithelial dysplasia. tissue microarrays were constructed and immunohistochemical staining for il-1β, il-6, il-10, ... | 2017 | 28736845 |
| effect of helicobacter pylori infection on outcomes in resected gastric and gastroesophageal junction cancer. | helicobacter pylori (h pylori) infection is a known risk factor for gastric cancer (gc) and has been linked with gastroesophageal junction (gej) cancer. studies examining the relationship between h. pylori infection, gc characteristics and prognosis are limited and have yielded conflicting results. we report on the clinicopathologic characteristics and oncologic outcomes of gastric and gej cancer patients with and without a history of h. pylori treated at our institution. | 2017 | 28736645 |
| perioperative practices concerning one anastomosis (mini) gastric bypass: a survey of 210 surgeons. | there is currently little evidence available on the perioperative practices concerning one anastomosis/mini gastric bypass (oagb/mgb) and no published consensus amongst experts. even the published papers are not clear on these aspects. the purpose of this study was to understand various perioperative practices concerning oagb/mgb. | 2017 | 28735375 |
| the gastric and intestinal microbiome: role of proton pump inhibitors. | the discovery of helicobacter pylori and other organisms colonizing the stomach and the intestines has shed some light on the importance of microbiome in maintaining overall health and developing pathological conditions when alterations in biodiversity are present. the gastric acidity plays a crucial role in filtering out bacteria and preventing development of enteric infections. in this article, we discuss the physiology of gastric acid secretion and bacterial contribution to the composition of ... | 2017 | 28733944 |
| surveillance strategy according to age after endoscopic resection of early gastric cancer. | whether surveillance strategy after curative endoscopic submucosal dissection (esd) for early gastric cancer (egc) differs in young patients is unclear. this study aimed to evaluate the risk of metachronous and extragastric recurrence in young patients with egc after curative esd. | 2017 | 28733737 |
| characterization of clarithromycin-resistant helicobacter pylori strains in iran: a systematic review and meta-analysis. | the high prevalence of clarithromycin-resistant strains of helicobacter pylori is a main challenge for the successful treatment of gastrointestinal infections. point mutations in the 23s rrna gene are one of the main mechanisms leading to the resistance to clarithromycin in iran. the purpose of the present review was to evaluate the prevalence of clarithromycin-resistant h. pylori strains in iran and to identify the major molecular mechanisms of resistance in the resistant isolates. | 2017 | 28732793 |
| secondary antibiotic resistance of helicobacter pylori isolates in israeli children and adults. | failure of standard therapy for helicobacter pylori infections results primarily from increasing antibiotic resistance. patients in israel are referred for h. pylori culture after failure of at least two therapeutic regimens. | 2017 | 28732784 |
| in vivo diagnosis of early-stage gastric cancer found after helicobacter pylori eradication using probe-based confocal laser endomicroscopy. | early-stage gastric cancer (egc) found after helicobacter pylori (hp) eradication often displays non-tumorous regenerative epithelium and/or maturated tumorous epithelium overlying the cancerous tissue, which may confuse endoscopic and histological diagnosis. probe-based confocal laser endomicroscopy (pcle) enables in vivo real-time optical biopsy. we compared the diagnostic yields for these egc cases using conventional white light endoscopy (wl), magnifying endoscopy with narrow-band imaging (m ... | 2017 | 28731617 |
| changing trends in stomach cancer throughout the world. | the paper aims to discuss the global trends in gastric cancer incidence in relation to important factors involved in the pathogenesis of gastric cancer. | 2017 | 28730504 |
| crypt hyperplastic enteropathy in distal duodenum in helicobacter pylori infection - report of two cases without evidence of celiac disease. | patients with helicobacter pylori (hp) infection have been reported to have in addition to duodenitis architectural changes of the duodenal bulb mucosa including villous atrophy and crypt hyperplasia. we here for the first time present two cases of hp-infected adult patients with a crypt hyperplastic enteropathy also in the distal duodenum mimicking celiac disease (cd). | 2017 | 28730262 |
| severe upper gastrointestinal bleeding determined by a gastric lymphoma associated with helicobacter pylori-positive atrophic gastritis. | the pathogenesis of gastric cancer regardless of histological structure is a classic example of gene-environment interaction, and an important epidemiological aspect was the recognized association with helicobacter pylori infection. this paper describes a case of gastric mucosa-associated lymphoid tissue (malt) lymphoma in a young patient whose first sign of the disease was upper gastrointestinal bleeding and associated hemorrhagic shock. the patient is a 31-year-old man, diagnosed by endoscopy ... | 2017 | 28730251 |
| molecular characterization of the human stomach microbiota in gastric cancer patients. | helicobacter pylori (hp) is the primary cause of gastric cancer but we know little of its relative abundance and other microbes in the stomach, especially at the time of gastric cancer diagnosis. here we characterized the taxonomic and derived functional profiles of gastric microbiota in two different sets of gastric cancer patients, and compared them with microbial profiles in other body sites. paired non-malignant and tumor tissues were sampled from 160 gastric cancer patients with 80 from chi ... | 2017 | 28730144 |
| structural insight into the binding of c60-derivatives with enoyl-pyruvate transferase from helicobacter pylori. | helicobacter pylori (h. pylori) is a human pathogen associated with acute gastritis and peptic ulcer. the mura enzyme is an important drug target for the identification of ligands with improved efficacy and acceptable pharmaco-kinetic properties. we developed a homology model of h. pylori mura followed by refinement and molecular dynamics (md) simulations. a total of 16 c60-derivatives were docked and its docking score were compared. some of the known inhibitors were also similarly characterized ... | 2017 | 28729760 |
| the potential value of serum pepsinogen for the diagnosis of atrophic gastritis among the health check-up populations in china: a diagnostic clinical research. | the aim of this study is to assess the validity of the measurement of pepsinogen as a screening test for chronic atrophic gastritis (ag) in health check-up populations in china. | 2017 | 28728545 |
| the effect of helicobacter pylori eradication on the metachronous neoplasm after endoscopic resection for gastric dysplasia. | helicobacter pylori (hp) infection is an important risk factor for gastric carcinogenesis. although several studies have investigated the effect of hp eradication on the development of metachronous neoplasm after endoscopic resection of the gastric dysplasia, the evidence is still insufficient to make a clear conclusion. the aims of this study was to evaluate the risk factors for the development of metachronous neoplasm after endoscopic resection of gastric dysplasia and to investigate the effec ... | 2017 | 28728313 |
| the effect of h2 receptor antagonist in acid inhibition and its clinical efficacy. | the first histamine h2 receptor antagonists (h2ras) were developed in the early 1970s. they played a dominant role in treating peptic ulcer disease and gastroesophageal reflux disease (gerd). h2ras block the production of acid by h(+), k(+)-atpase at the parietal cells and produce gastric luminal anacidity for varying periods. h2ras are highly selective, and they do not affect h1 receptors. moreover, they are not anticholinergic agents. sequential development of h2ras, proton pump inhibitors (pp ... | 2017 | 28728310 |
| potential association of il1b polymorphism with iron deficiency risk in childhood helicobacter pylori infection. | helicobacter pylori (h. pylori) infection occurs predominantly in childhood. host immune response gene polymorphism is reported to affect the susceptibility to h. pylori infection and the outcome of h. pylori-related gastric cancer. however, not all h. pylori-infected patients exhibit iron deficiency. the relationship between host genetic polymorphisms and iron deficiency mediated by h. pylori infection is not well understood. | 2017 | 28727656 |
| association of vagotomy and decreased risk of subsequent ischemic stroke in complicated peptic ulcer patients: an asian population study. | the primary management of peptic ulcers is medical treatment. persistent exacerbation of a peptic ulcer may lead to complications (perforation and/or bleeding). there has been a trend toward the use of a less invasive surgical simple suture, simple local suture or non-operative (endoscopic/angiography) hemostasis rather than acid-reducing vagotomy (i.e., vagus nerve severance) for treating complicated peptic ulcers. other studies have shown the relationship between high vagus nerve activity and ... | 2017 | 28726018 |
| toward early detection of helicobacter pylori-associated gastric cancer. | gastric cancer is typically diagnosed at a late stage, leading to poor prognoses. helicobacter pylori is responsible for 70% of gastric cancers globally, and patients with this bacterial infection often present with early stages of the carcinogenic pathway such as inflammation or gastritis. although many patients continue to progress to advanced-stage disease after antibacterial treatment, there are no follow-up screening protocols for patients with a history of h. pylori. | 2017 | 28725964 |
| helicobacter pylori infection status had no influence on upper gastrointestinal symptoms: a cross-sectional analysis of 3,005 japanese subjects without upper gastrointestinal lesions undergoing medical health checkups. | this study aimed to evaluate the influence of helicobacter pylori infection and its eradication on the upper gastrointestinal symptoms of relatively healthy japanese subjects. | 2017 | 28725170 |
| which regimens should be used and which rejected for the treatment of helicobacter pylori? | | 2017 | 28725073 |
| correlation between virulence markers of helicobacter pylori in the oral cavity and gastric biopsies. | the clinical outcome of helicobacter pylori infection has been associated with virulence factors. the presence of these factors is useful as molecular markers in the identification of the high risk for developing severe gastric pathologies. | 2017 | 28724047 |
| antibiotic susceptibility of helicobacter pylori strains isolated from iranian children: high frequency of a2143g point mutation associated with clarithromycin resistance. | increasing antibiotic resistance in helicobacter pylori is a global concern and is associated with treatment failure. the aim of this study was to evaluate antibiotic resistance of h. pylori to different antibiotics including amoxicillin, erythromycin, ciprofloxacin, furazolidone, tetracycline, metronidazole and clarithromycin. in addition, detection of a2143g mutation in clarithromycin resistant isolates was performed using real-time pcr technique. | 2017 | 28720314 |
| ten-day quadruple therapy comprising proton pump inhibitor, bismuth, tetracycline, and levofloxacin is more effective than standard levofloxacin triple therapy in the second-line treatment of helicobacter pylori infection: a randomized controlled trial. | proton pump inhibitor (ppi)-amoxicillin-fluoroquinolone triple therapy is recommended as a second-line treatment of helicobacter pylori infection in the maastricht v/florence consensus report. however, the eradication rate of this standard salvage treatment is suboptimal. the objective of this study is to compare the efficacy of esomeprazole-bismuth-tetracycline-levofloxacin therapy (tl quadruple therapy) and esomeprazole-amoxicillin-levofloxacin triple therapy (al triple therapy) in rescue trea ... | 2017 | 28719592 |
| compounded levofloxacin triple therapy is safe and effective for refractory helicobacter pylori. | failure of first line and subsequent helicobacter pylori therapy is a significant problem, as alternate treatments are cumbersome and difficult to access. the purpose of this study was to evaluate the efficacy and safety of a compounded levofloxacin triple therapy in clinical practice as a second or third-line salvage regimen for helicobacter pylori. patients referred after first or subsequent treatment failures were prescribed compounded levofloxacin 500 mg, amoxicillin 1 g, and esomeprazole 40 ... | 2017 | 28719375 |
| effectiveness of helicobacter pylori eradication in pregnant women with idiopathic thrombocytopenic purpura. | platelet counts increase after eradication of helicobacter pylori (hp) infection in non-pregnant patients with hp-associated idiopathic thrombocytopenic purpura (itp); however, improvement in pregnant patients has not yet been reported. we treated four pregnant women for hp-positive itp after hp eradication. in three of four cases, platelet counts increased to levels exceeding 10 × 10(9) /l two weeks after eradication, and these levels were maintained until delivery. vaginal deliveries were unco ... | 2017 | 28718212 |
| gastric hyperplastic polyps associated with proton pump inhibitor use in a case without a history of helicobacter pylori infection. | a 56-year-old man with gastroesophageal reflux disease (gerd) was referred to our hospital. esophagogastroduodenoscopy (egd) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of helicobacter pylori infection. he received omeprazole (20 mg) once daily for the gerd. egd was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (ghps) were detected. the ghps increased in size as the omeprazole treatment ... | 2017 | 28717077 |
| helicobacter pylori modulates host cell responses by cagt4ss-dependent translocation of an intermediate metabolite of lps inner core heptose biosynthesis. | highly virulent helicobacter pylori cause proinflammatory signaling inducing the transcriptional activation and secretion of cytokines such as il-8 in epithelial cells. responsible in part for this signaling is the cag pathogenicity island (cagpai) that codetermines the risk for pathological sequelae of an h. pylori infection such as gastric cancer. the cag type iv secretion system (cagt4ss), encoded on the cagpai, can translocate various molecules into cells, the effector protein caga, peptidog ... | 2017 | 28715499 |
| novel risk stratification for metachronous recurrence after curative endoscopic submucosal dissection for early gastric cancer. | this study stratified the risk of developing metachronous gastric cancer (mgc) after curative endoscopic submucosal dissection (esd) of early gastric cancer (egc) to enable the customization of endoscopic surveillance for mgc. | 2017 | 28713064 |
| antiulcer properties of fruits and vegetables: a mechanism based perspective. | gastric ulcer is the damage caused to mucosal layer of the stomach under the action of various factors like high levels of acid and pepsin, invasion by helicobacter pylori, etc. although most cases have been controlled and the rate of ulcer occurrence has reduced over the last few decades, gastric ulcer still holds a prime concern today. a range of palliative medicines comprising proton pump inhibitors, h2 receptor antagonists, cox-2 inhibitors (coxibs) is widely in use and patients have also be ... | 2017 | 28711545 |
| a rare case of gastric mixed adenoneuroendocrine carcinoma (manec) with gastric helicobacter pylori-negative mucosa-associated lymphoid tissue (malt) lymphoma. | | 2017 | 28710240 |
| an alternative view on the necessity of egd before sleeve gastrectomy. | esophagogastroduodenoscopy (egd) is particularly recommended for choosing a surgical method to be used with asymptomatic patients and for the assessment of symptomatic patients prior to sleeve gastrectomy. the presence of hiatal hernia, for instance, is a relative contraindication. egd is used for malignancy scanning as well as surgical planning, but seems inefficient in determining postoperative complications. | 2017 | 28709560 |
| detection of viable helicobacter pylori inside free-living amoebae in wastewater and drinking water samples from eastern spain. | helicobacter pylori is one of the most concerning emerging waterborne pathogens. it has been suggested that it could survive in water inside free-living amoebae (fla), but nobody has studied this relationship in the environment yet. thus, we aimed to detect viable h. pylori cells from inside fla in water samples. sixty-nine wastewater and 31 drinking water samples were collected. fla were purified and identified by pcr and sequencing. for exclusively detecting h. pylori inside fla, samples were ... | 2017 | 28707344 |
| functional gastrointestinal disorders in children from low socio-economic status and helicobacter pylori infection. | most studies on functional gastrointestinal disorders (fgids) in children are based on data from the northern hemisphere. scientific reports are arising in south american population, but little is still known about children from low socio-economic status (ses), where helicobacter pylori infection is endemic. our objective was to evaluate the prevalence of fgids in school children from low ses and its relationship with h. pylori infection. | 2017 | 28707297 |
| appropriateness of the study of iron deficiency anemia prior to referral for small bowel evaluation at a tertiary center. | to evaluate the adequacy of the study of iron deficiency anemia (ida) in real life practice prior to referral to a gastroenterology department for small bowel evaluation. | 2017 | 28706428 |