| the action of antituberculosis drugs in short-course chemotherapy. | | 1985 | 3931319 |
| tailoring a time-bomb. inadvertent genetic engineering. | | 1985 | 3931520 |
| the effect of ethambutol on tubercle bacilli within cultured human macrophages. | ethambutol (emb) generally is believed to be clinically mycobacteriostatic. this concept was reexamined in an in vitro model of human tuberculosis that has direct relevance to in vivo effects in human subjects. cultured human monocyte-derived macrophages infected with virulent erdman tubercle bacilli were treated with emb, and the resulting antimycobacterial consequences were measured by counts of acid-fast bacilli and bacterial colony-forming units. when added immediately after infection of the ... | 1985 | 3931521 |
| antituberculosis activity of ofloxacin (dl 8280) on experimental tuberculosis in mice. | ofloxacin (dl 8280) is rapidly eliminated from mouse organs. it disappears quickly from the lungs and the spleen and more slowly from the liver and the kidneys. the antituberculosis activity of this agent was shown in mice when the agent was given intraperitoneally at daily doses of 1 mg per mouse (approximately 42 mg/kg). the number of viable bacteria of mycobacterium tuberculosis strain h37rv contained in the liver decreased markedly in the mice treated with ofloxacin, and the inhibitory effec ... | 1985 | 3931525 |
| pulmonary mycobacterium tuberculosis in acquired immune deficiency syndrome. | a case of pulmonary infection with mycobacterium tuberculosis in a patient with the acquired immune deficiency syndrome (aids) was studied. diagnosis of aids was confirmed by the finding of pulmonary m tuberculosis with oral and oesophageal candidiasis accompanied by characteristic immunological changes with evidence of infection with human t cell lymphotropic virus iii. treatment of this patient was complicated by an unusual drug interaction between rifampicin and ketoconazole, leading to subth ... | 1985 | 3931740 |
| mycobacterium bovis bcg vaccine fails to protect protein-deficient guinea pigs against respiratory challenge with virulent mycobacterium tuberculosis. | specific-pathogen-free hartley guinea pigs were maintained on isocaloric-purified diets either adequate (30%) or moderately deficient (10%) in protein. half of each diet group was vaccinated with viable mycobacterium bovis bcg. six weeks later, all animals were challenged by the respiratory route with virulent mycobacterium tuberculosis h37rv. at intervals of 1, 2, and 3 weeks postchallenge, guinea pigs from each diet and vaccination group were skin tested with tuberculin and sacrificed. protein ... | 1985 | 3932212 |
| rapid and sensitive identification of mycobacterium tuberculosis. | the fatty acid constituents of 14 species of mycobacterium (14 isolates) and one isolate each of corynebacterium xerosis, nocardia asteroides, and streptomyces albus were examined with the purpose of distinguishing mycobacterium tuberculosis from other acid-fast bacilli. combined thin-layer chromatography (tlc) of methyl mycolates and gas-liquid chromatography (glc) of shorter-chain fatty acid esters provided an unequivocal identification of m. tuberculosis in a matter of 2 to 3 days. the method ... | 1985 | 3932458 |
| improved detection times for mycobacterium avium complex and mycobacterium tuberculosis with the bactec radiometric system. | a total of 2,559 routine clinical specimens were cultured for mycobacteria by using bactec middlebrook 7h12 medium (bactec), lowenstein-jensen slants (lj), and mycobactosel selective middlebrook 7h11 slants (m7h11). thirty-three isolates (1.3%) of m. avium complex and 82 isolates (3.2%) of m. tuberculosis were recovered. the bactec mean detection time of m. avium complex from 27 smear-negative specimens was earlier than that of conventional media for both decontaminated respiratory specimens (ba ... | 1985 | 3932460 |
| [role of bacteriological research in the the expertise of the work capacity of patients with respiratory organ tuberculosis]. | | 1985 | 3932997 |
| [microbiological diagnosis of renal tuberculosis]. | | 1985 | 3932998 |
| [trends in the development of drug resistance in the causative agent of tuberculosis (based on data from an examination of hospital patients)]. | | 1985 | 3932999 |
| [effect of x-ray irradiation on the biological properties of mycobacterium tuberculosis]. | | 1985 | 3933000 |
| [evaluation of mycobacterium tuberculosis virulence by the intracerebral infection of guinea pigs]. | | 1985 | 3933001 |
| on the possibility of cross-resistance between rifampicin and clofazimine in mycobacteria--a laboratory study. | one-way cross-resistance to rifampicin in clofazimine-resistant substrains of mycobacterium smegmatis atcc 607 was seen in 4 instances, whereas at most a borderline situation (probably within the experimental error) occurred in this respect with mycobacterium parafortuitum 16009 and with strains of mycobacterium "lufu" and mycobacterium fortuitum. clofazimine-resistant sub-strains were not isolated from the parental strains of mycobacterium tuberculosis. methodological influences (the gradient p ... | 1985 | 3933210 |
| present position of microscopy and of culture in diagnostic mycobacteriology. | the relative merits of microscopy and culture are discussed; it is attempted to review the possible reasons why microscopy is considered as unreliable in tb diagnosis, including the probably false application of bayes' theorem. in the author's opinion, microscopy still holds a firm position in the rapid and relatively reliable detection of pulmonary tb. as for culture, it is highly questionable if "better media" could accelerate the growth rate of tubercle bacilli. therefore, it should be attemp ... | 1985 | 3933212 |
| [ultrastructural organization of mycobacterium tuberculosis processed by cryogenic ultratomy]. | the ultrastructural organization of m. tuberculosis has been studied by the method of cryo-ultratomy. the cell-wall structures and the connective formations localized in the cytoplasm between parallel intracellular membranes have been revealed. ethylene glycol and polyvinyl alcohol have been shown to be the most suitable cryoprotecting agents. | 1985 | 3933224 |
| evidence for an informal clinical policy resulting in high use of a very-low-yield test. | the actual and self-reported practice regarding the use of cerebrospinal fluid cultures for mycobacterium tuberculosis was examined. all neurology house staff members surveyed, 62 percent of internal medicine house staff members, and none of pediatric house staff members reported that they would order mycobacterial cultures of cerebrospinal fluid routinely. the actual practice was comparable, with 71 percent of cerebrospinal fluid specimens being subjected to culture for mycobacteria on the neur ... | 1985 | 3933342 |
| the role of sampling in the detection of microbial contamination on cadaveric allograft skin used as a biological wound dressing. | the availability of cryopreservation and low temperature storage techniques for cadaveric allograft skin allows it to be preserved while microbial assessments are made before its use as a temporary biological dressing on burn wounds. in a 300-donor, 5-year prospective study, we tested ten skin samples from defined areas on each donor for microbiological contamination. although the skin from 52.3 per cent of the donors possessed some detectable residual microbial contamination after surgical body ... | 1985 | 3933768 |
| intralaboratory comparison of drug susceptibility testing of mycobacterium tuberculosis by bactec and conventional methodology. | the bactec radiometric method of drug susceptibility testing of mycobacterium tuberculosis is a reliable and rapid diagnostic tool in clinical mycobacteriology. however, large scale comparative studies have also shown that the level of agreement with standard methodology was less satisfactory with strains resistant to ethambutol and streptomycin than with strains resistant to rifampin and to isoniazid. since disagreement with drug resistance strains is far more frequent than with drug susceptibl ... | 1985 | 3933805 |
| the disinfectant dilemma. | | 1985 | 3934104 |
| interlaboratory drug susceptibility testing of mycobacterium tuberculosis by a radiometric procedure and two conventional methods. | a total of 224 recent isolates of mycobacterium tuberculosis from 163 patients selected to have multidrug resistance were tested against streptomycin (sm), isoniazid, rifampin, and ethambutol (emb) by the rapid radiometric bactec method and two conventional proportion methods: the world health organization (who) method, using lowenstein-jensen medium; and the veterans administration reference laboratory for mycobacteria (va) method, using middlebrook 7h10 agar medium. the results were compared, ... | 1985 | 3934209 |
| quantification of lymphocyte activation by measurement of dna polymerase alpha activity. | measurement of the activity of the enzyme dna polymerase alpha has been investigated with regard to its potential usefulness as a method for the detection and quantification of lymphocyte activation in vivo. a modified enzyme assay was developed in order to optimise measurement of activity in crude homogenates of cells or tissues, thus allowing the convenient handling of multiple samples. specificity of the assay for polymerase alpha was ensured by the inclusion in the assay mixture of dideoxyth ... | 1985 | 3934283 |
| synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against mycobacterium species. | a series of compounds, which are analogues of 2,2'-dithiobis(benzamide), were synthesized and tested for in vitro antibacterial activity against mycobacterium tuberculosis h37rv including resistant strains against streptomycin, kanamycin, or isonicotinic acid hydrazide. mics of these compounds against atypical mycobacteria, mycobacterium kansasii and mycobacterium intracellulare were also examined. structure-activity relationships were found in a series of (acyloxy)alkyl ester derivatives depend ... | 1985 | 3934384 |
| frequency of drug-resistant mycobacteria. | | 1985 | 3934401 |
| [clinical course and chemotherapy of hyperchronic destructive pulmonary tuberculosis]. | | 1985 | 3934660 |
| [clinical aspects of secondary resistance in pulmonary tuberculosis]. | | 1985 | 3934690 |
| [primary resistance]. | | 1985 | 3934691 |
| [the transmission of mycobacteria through the fiberoptic bronchoscope]. | transmission of mycobacterium tuberculosis by the flexible fiberoptic bronchoscope was suspected in two patients with positive cultures from bronchial washings but with negative cultures from sputum specimens and no clinical or radiological evidence of active tuberculosis, in both cases, a patient with sputum smear-positive pulmonary tuberculosis had been examined with the same bronchoscope the day before. in one case, mycobacteriophage typing of the cultures of the consecutively examined patien ... | 1985 | 3934749 |
| diagnosis of sputum smear- and sputum culture-negative pulmonary tuberculosis. | a group of patients with new or enlarging apical lung lesions thought to be tuberculous was randomly selected for observation without treatment. all were tuberculin-positive and all had sputum negative for mycobacterium tuberculosis on direct examination and on culture. of the 152 patients, 88 (58%) developed bacteriologically confirmed pulmonary tuberculosis during a follow-up period of up to 65 months. | 1985 | 3934771 |
| killing of macrophage-ingested mycobacteria by rifampicin, pyrazinamide, and pyrazinoic acid alone and in combination. | a study was undertaken with the aim of assessing the killing capacity of rifampicin, pyrazinamide, and pyrazinoic acid on macrophage-ingested, live mycobacterium tuberculosis. the 3 drugs were used at concentrations corresponding to the average peak levels observed in humans after administration of therapeutic doses that had been found to penetrate into macrophages in a previous study. the degree of killing was studied after exposure of the cell cultures to the individual drugs and their combina ... | 1985 | 3935020 |
| tuberculosis chemotherapy today. | effective chemotherapy of tuberculosis not only reduces morbidity and mortality, but it is a powerful mechanism to control further spread of infection. although conventional therapy for 18-24 months is highly effective, a major disadvantage is non-compliance of patients in completing the full course of therapy. with better understanding of bacteriologic action of many antituberculous drugs, the disease can now be cured in six to nine months of bactericidal chemotherapy. isoniazid and rifampin fo ... | 1985 | 3935036 |
| [short-course chemotherapy of pulmonary tuberculosis and several problems concerning its use, especially in india]. | | 1985 | 3935193 |
| soluble antigen fluorescent antibody test in serodiagnosis of pulmonary tuberculosis. | the significance of the modified soluble antigen fluorescent antibody (safa) test in the laboratory diagnosis of pulmonary tuberculosis has been evaluated. the test has been established by using mycobacterial saline extract as antigen. a total of 191 serum samples were subjected to this test; of these, 126 were from cases of pulmonary tuberculosis (untreated, and at different stages of treatment, 2 were from cases of non-tuberculous mycobacteriosis), 65 from control cases including tuberculin re ... | 1985 | 3935470 |
| leucocyte migration inhibition response of mycobacterium habana with sensitized animals and cells from leprosy patients. | response of mycobacterium habana sensitized mouse cells against habanin (sonicated extract) lepromin (dharmendra) and tuberculin has been studied in the leucocyte migration inhibition test. the homologous antigenic response has evoked maximum inhibition as compared to heterologous antigens but close antigenic association has also been observed with lepromin and tuberculin. with human cells from leprosy patients these antigens have evoked analogous response indicating cross immunogenicity of m. h ... | 1985 | 3935726 |
| residuals in multiple regression analysis. | an examination of residuals can be used as a technique to determine the best model for use in multiple-regression analysis. in addition to r2 and the fisher f ratio, a complete analysis of residuals has been used by statisticians for many years to estimate bias and to choose the best equation to fit physicochemical as well as biological and psychosociological data. however, residual analysis has seldom appeared in studies in pharmaceutics, pharmacology, or medicinal chemistry. this report gives ... | 1985 | 3935772 |
| circulating immune complexes in pulmonary tuberculosis. | the presence of circulating immune complexes (cic) in sera from patients with pulmonary tuberculosis was demonstrated by 3 techniques (a) latex agglutination (b) 3.5% peg precipitation and determination of optical density (o.d.) at 280 nm and (c) radioimmunoassay (ria) of cic using bovine spermatozoa. 40 normal control sera and 100 t.b. patients sera were included in the study. 12% cases were positive for cic by all the 3 methods mentioned above, 13% were negative by all the 3 methods and the re ... | 1985 | 3935794 |
| [studies on the ofloxacin resistance of tubercle bacilli]. | | 1985 | 3935845 |
| suppression of the development of experimental allergic encephalomyelitis by suramin. | suramin was tested for its ability to suppress experimental allergic encephalomyelitis. prophylactic administration caused significant reduction in the severity of the disease, incidence of paralysis and cellular infiltration in nervous tissue. therapeutic treatment with suramin also caused a reduction in the severity of the disease, the incidence of paralysis and cellular infiltration, but to a lesser extent. significantly fewer animals were paralysed for more than two days on therapeutic treat ... | 1985 | 3935948 |
| [use of the immunofluorescence technic to detect l-transformed forms of the agent of tuberculosis]. | | 1985 | 3936032 |
| [case of primary poly-drug resistance of mycobacteria from a 70-year-old tuberculosis patient]. | | 1985 | 3936033 |
| protection to mice afforded by bcg vaccines against an aerogenic challenge by three mycobacteria of decreasing virulence. | specific pathogen-free mice were vaccinated subcutaneously with 10(7) cfu of bcg pasteur or bcg glaxo and 30 or 90 days later, the mice were challenged aerogenically with mycobacterium tuberculosis (erdman or south indian strains) or with m. avium. both vaccines induced substantial levels of resistance to tuberculosis and tuberculin hypersensitivity. there was no detectable difference in the host response to the three aerogenic challenges which could be related in any way to the immunogenicity o ... | 1985 | 3936247 |
| a possible link between vitamin d deficiency and impaired host defence to mycobacterium tuberculosis. | | 1985 | 3936248 |
| immunodiffusion analyses of environmental mycobacteria isolated in zaire. | unclassified, acid-fast strains isolated from the environment in zaire were analysed by comparative immunodiffusion for taxonomical purposes. these strains have previously been shown to differ physiologically and/or biochemically from all other known mycobacteria. the analyses confirmed that these strains belong to genus mycobacterium and showed, furthermore, that they were more closely related to the slowly growing mycobacteria, including mycobacterium tuberculosis, than to the rapidly growing ... | 1985 | 3936310 |
| [antitubercular agents. xxxi. tetrazole as a potential antitubercular agent]. | | 1985 | 3936623 |
| activation of macrophages for antimycobacterial activity. | the role of macrophage hydrogen peroxide in defense against mycobacterial infection is discussed - not because this is necessarily any more important than other macrophage products (reviews: [1, 2]) but more as a reflection of recently available information. first, we will describe an accumulation of evidence that peroxide has a role, then we will stage an enquiry into whether interferon-gamma (ifn gamma) activates macrophages for peroxide release, and finally we will give an appraisal of direct ... | 1985 | 3936782 |
| modified rapid radiometric method for detection of mycobacterium tuberculosis from sputum samples. | a modified, simple and radiometric method for early detection of m. tuberculosis from sputum samples has been developed using a biphasic vial system for detection of 14c-co2 produced by the metabolism of 14c-u-acetate on glycerol-free lowenstein-jensen medium (ljm). of the 84 smear positive sputum samples examined, 85.7% and 86.9% were scored positive by radiometric and visual methods respectively. the detection rates at 1st, 2nd and 3rd week of the test were 53.3%, 60.7% and 82.1% by radiometry ... | 1985 | 3936813 |
| intestinal tuberculosis: bacteriological study of tissue obtained by colonoscopy and during surgery. | the biopsy tissue obtained during surgery and colonoscopy from 28 cases of intestinal tuberculosis was utilized for isolation and identification of mycobacteria. the mycobacteria could be isolated in 12 (42%) of 28 patients. colonoscopy can be a successful method of bacteriological diagnosis of intestinal tuberculosis. mycobacteria were scarcely ever seen on histological sections. combined use of guinea pig inoculation and culture was more rewarding than either alone. the yield of positive cultu ... | 1985 | 3936942 |
| [prevention of resistance to rifampicin by pyrazinamide in experimental tuberculosis in the mouse]. | the capacity of pyrazinamide (pza) to prevent the selection of rifampicin (rmp) resistant mutants was tested by the intravenous innoculation of 160 mice with 2 x 10(6) c.f.u. of m. tuberculosis, and two weeks later, the treatment of the mice either with 10 mg/kg/day rmp alone or with rmp + pza 150 mg/kg/day. after three months of treatment, lungs and spleen were culture positive in respectively 95% and 90% of the mice treated with rmp alone and in 37% and 24% of the mice treated by rmp + pza (p ... | 1985 | 3937188 |
| [controlled study comparing 3 daily chemotherapy regimens for six months in pulmonary tuberculosis in routine practice in algiers. results at 30 months]. | three anti-tuberculous regimens were compared in algiers. the three regimens use isoniazid and rifampicin every day for six months; two of them used a third drug, ethambutol or pyrazinamide for the first three months. the results at 12 months after cessation of chemotherapy have already been reported. at 30 months (or 24 months after the end of treatment) the results were analysed for 513 cases: in 27 cases (5%) there was a relapse or therapy failed. of 21 relapses 13 occurred in the first six m ... | 1985 | 3937189 |
| [immunopathologic aspects of local tuberculous tissue reactions]. | the importance of immunologic factors in the local defense against myobacterial disease derives from different mechanisms of action. these may be characterized as follows: mycobacteria act as antigens or antigenic fragments to cause local sensitization, activation, and proliferation of t-lymphocytes leading to the formation of giant cells of langhans' type. antibodies play a role only as opsonines and are not directly responsible for the destruction of the invading organisms. lymphokines on the ... | 1985 | 3937369 |
| effect of rifandin on ultrastructure of tubercle bacilli. | | 1985 | 3937689 |
| evaluation of a bioluminescence assay for rapid antimicrobial susceptibility testing of mycobacteria. | the antimicrobial susceptibility of mycobacterium tuberculosis h37rv and 17 clinical isolates of the same species was determined using a bioluminescence assay to measure adenosine triphosphate (atp) produced by bacteria in the broth dilution test performed in dubos-tween-albumin broth. the results were compared with those obtained with the standard dilution proportional method performed on löwenstein-jensen medium. the drugs tested were streptomycin, rifampin, ethambutol and isoniazid. there was ... | 1985 | 3937733 |
| elisa of igg antibody to m. tuberculosis antigen 5 for serodiagnosis of tuberculosis. | | 1985 | 3937807 |
| diagnosing tuberculous pleural effusion: comparative sensitivity of mycobacterial culture, histopathology and adenosine deaminase activity. | | 1985 | 3937839 |
| ambivalent properties of gold drugs in adjuvant induced polyarthritis in rats. | we evaluated the antiarthritic activity of gold sodium aurothiomalate (gstm) and auranofin (af) against experimental polyarthritis induced in 3 rat strains using 3 different adjuvants. these 2 gold drugs were found to either stimulate, inhibit or have no effect upon the development of arthritis, dependent upon the rat strain and/or the adjuvant used. the ambivalent antiarthritic activities of gstm and af did not appear to be associated with any variations in serum gold levels. these results high ... | 1985 | 3937896 |
| [the biological properties and virulence of a lysogenic strain from an sm-resistant strain of mycobacterium tuberculosis]. | | 1985 | 3937930 |
| [the latest topics concerning pyrazinamide]. | | 1985 | 3937931 |
| [chemotherapy of patients with chronic destructive pulmonary tuberculosis in cases of mycobacterial resistance to rifampicin and isoniazid]. | | 1985 | 3937942 |
| [characteristics of infiltrative pulmonary tuberculosis located in the inferior lobe]. | | 1985 | 3937943 |
| numerical identification of slowly growing mycobacteria. | numerical identification using the range of a species defined as (m +/- 2s)% was shown to be suitable for the identification of slowly growing mycobacteria. in the formula, m is the mean matching coefficient for individual strains of each species to the hypothetical median organism pattern of their own species and s is the standard deviation. | 1985 | 3937958 |
| [biochemical activity and drug sensitivity of mycobacterium tuberculosis in selected forms of pulmonary tuberculosis]. | | 1985 | 3938011 |
| [studies with the bactec 460 system. evaluation of sensitivity in mycobacterium tuberculosis. comparison of the radiometric with the conventional method]. | | 1985 | 3938016 |
| [clinical picture and course of chronic destructive pulmonary tuberculosis in patients secreting l forms of the causative agent]. | | 1985 | 3938018 |
| [lyophilized nutrient media for isolating mycobacterium tuberculosis from pathological material]. | | 1985 | 3938020 |
| [in vitro leukocyte reaction to the antigens of human and bovine mycobacteria in pulmonary tuberculosis patients]. | | 1985 | 3938021 |
| [bacteriologic diagnosis of miliary tuberculosis at the present time]. | | 1985 | 3938039 |
| liposomes-mycobacteria incubation systems as a partial model of host-parasite interaction at cell membrane level. | the multilamellar lecithin-cholesterol liposomes entrapping carboxyfluorescence as a specific marker were prepared to be incubated with mycobacteria. the extent of resulting liposomal lysis was measured by marker release. mycobacteria were highly active in this respect regardless of the species. staphylococci were much less active and e. coli was completely inactive. molecular species of lecithin and their ratio to cholesterol were related with the liposome sensitivity to mycobacteria. ultrastru ... | 1985 | 3938493 |
| mechanism of bactericidal activity of lysolecithin and its biological implication. | lysolecithin exhibited bactericidal effect on mycobacteria and staphylococci, but not on e. coli. the effect on staphylococci was manifested shortly after exposure, but that on mycobacteria was of the delayed type. the mycobactericidal activity was dependent on the fatty acid moiety of the chemical structure reflecting the cytotoxicity of the free form. the activity on staphylococci was not, however, of such fatty acid dependency and showed the same pattern of molecular species in hemolytic acti ... | 1985 | 3938494 |
| cerebrospinal fluid lysozyme in the diagnosis of tuberculous meningitis. | | 1985 | 3938771 |
| enzyme-linked immunosorbent assay (elisa) with staphylococcal protein a-horseradish peroxidase conjugate and exocellular native proteic antigens in an attempt to be used as a diagnostic tool in pulmonary tuberculosis. | | 1985 | 3938945 |
| production and partial characterization of monoclonal hybridoma antibodies to mycobacterium tuberculosis. | the production and partial characterization of monoclonal hybridoma antibodies against mycobacterium tuberculosis is described. 30 clones have been produced. their reactivity towards m. tuberculosis antigens have been tested in immunoblotting from sds-page, in crossed immunoelectrophoresis and in elisa. the mab's separated into four reactivity groups, one of which may be relevant in assays for antigen specific for m. tuberculosis. | 1985 | 3939074 |
| [indications for the surgical treatment of pulmonary tuberculosis explored on the basis of the bacteriologic examination of lung specimens]. | | 1985 | 3939214 |
| [effect of trace element on growth of mycobacterium tuberculosis h37 ra and bcg]. | | 1985 | 3939280 |
| elisa in the diagnosis of pulmonary tuberculosis. | | 1985 | 3939303 |
| [effect of secretory immunoglobin a on mycobacterium tuberculosis]. | | 1985 | 3939549 |
| [effect of antibiotic substances from higher plants on mycobacteria]. | | 1985 | 3939834 |
| initial roentgenographic manifestations of bacteriologically proven mycobacterium tuberculosis. typical or atypical? | admission chest roentgenograms were reviewed of all patients diagnosed with pulmonary and extrapulmonary tuberculosis (tb) at the medical college of georgia--eugene talmadge memorial hospital (mcg-etmh) during a five-year period from 1979 to 1983. of 75 patients included, 51 had pulmonary tb, whereas 24 had extrapulmonary infection. cavitary disease was common (28 of 51 patients with pulmonary tb). forty-four of 51 patients with pulmonary tb had involvement of apical and/or posterior segments of ... | 1986 | 3940794 |
| results of initial lymph node biopsy in homosexual men with generalized lymphadenopathy. | persistent, generalized lymphadenopathy (pgl) is considered part of the acquired immunodeficiency syndrome (aids)-related complex. the clinical course is usually benign, although some patients may evolve to aids. characteristic features on lymph node biopsy have been described. recently, large series of pgl have been reported in which many study patients have not undergone initial diagnostic biopsy. the value of such biopsy has been questioned. we report the clinical, pathologic, and laboratory ... | 1986 | 3944603 |
| biosynthesis of paf-acether: viii: impairment of paf-acether production in activated macrophages does not depend upon acetyltransferase activity. | activated peritoneal macrophages (m phi) from mice injected with bacilli calmette-guérin, trehalose dimycolate, a defined immunostimulant derived from mycobacterium tuberculosis, or streptococci c74 (st), synthesized two to three times less paf-acether (1-o-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in response to a zymosan challenge than did (0.7 +/- 0.2 nmol/mg protein) resident-m phi (r-m phi). to assess at which step the paf-acether biosynthetic pathway was impaired, the content in phosphol ... | 1986 | 3950403 |
| mycobacterium tuberculosis as a cause of peritonitis in a patient undergoing continuous ambulatory peritoneal dialysis. | tuberculous peritonitis is reported in an asian immigrant undergoing continuous ambulatory peritoneal dialysis (capd). unusual laboratory findings which resulted in delayed diagnosis are described. | 1986 | 3958507 |
| role of fiberoptic bronchoscopy in patients with hemoptysis and a normal chest roentgenogram. | we reviewed the charts of 48 consecutive patients who had fiberoptic bronchoscopy performed in the evaluation of hemoptysis with a normal chest roentgenogram. fiberoptic bronchoscopy provided a diagnosis other than endobronchial inflammation in only four patients--benign fibromuscular polyp in one patient, mycobacterium tuberculosis in 1 patient, and carcinoma in two others. a literature review revealed an overall 3 percent incidence of bronchogenic carcinoma in patients with hemoptysis and norm ... | 1985 | 3967521 |
| polymorphism of a mycobacterial antigen participating in cell-mediated immunity. | the cross-reactivity of crude sonic extracts of six species of mycobacteria was studied by skin tests in mice and guinea pigs immunised with live mycobacterium tuberculosis strain h37rv, and in patients with pulmonary tuberculosis. all slowly growing mycobacteria elicited a strong delayed hypersensitivity response, m. vaccae a moderate response and m. phlei a poor or no response. a specific target antigen for cell-mediated immunity, known to be present in m. tuberculosis, was also present in all ... | 1985 | 3968706 |
| the importance of leukocyturia in young adults. | the records of 1,000 asymptomatic male air force personnel were examined retrospectively for the results of 15 yearly examinations (1968 through 1983) of urinary sediment, beginning with subjects aged 18 to 33 years. the cumulative incidence of four to six or more wbcs per high-power field on one or more examinations was 31.8% after an average of 12.2 examinations per person over the 15-year period. in 107 subjects the wbcs were found on two or more occasions within five consecutive examinations ... | 1985 | 3970652 |
| radiometric method for testing susceptibility of mycobacteria to pyrazinamide in 7h12 broth. | the test of susceptibility to pyrazinamide requires an acid environment (ph less than or equal to 5.5). this, however, is not favorable to the growth of mycobacterium tuberculosis, especially in solid agar media. to obviate this difficulty, we developed a testing method with 7h12 broth medium and based on radiometric readings of the growth. the radiometric method employed in this study (bactec system) provides an opportunity to detect the dynamics of growth by daily recording of the growth index ... | 1985 | 3972987 |
| specificity of oligoclonal igg bands in sera from chronic relapsing experimental allergic encephalomyelitis guinea pigs. | the specificity of oligoclonal igg in sera from chronic relapsing eae guinea pigs was determined by using imprint electroimmunofixation. the response of oligoclonal igg to spinal cord and mycobacterium tuberculosis appeared to be equal in animals sacrificed during first remission and in those sacrificed after recovery from acute eae. in contrast, in animals sacrificed during or after the first relapse, the oligoclonal igg seems to be directed predominantly against spinal cord. in imprint electro ... | 1985 | 3973386 |
| the radiographic appearance of tuberculosis in patients with the acquired immune deficiency syndrome (aids) and pre-aids. | we reviewed the medical records and chest radiographs of 23 adult patients with culture-proved tuberculosis and verified acquired immune deficiency syndrome. seventeen patients, including 8 with disseminated tuberculosis, had positive sputum or bronchial washing cultures for mycobacterium tuberculosis. their initial pretreatment radiographs revealed hilar and/or mediastinal adenopathy in 10 patients (59%), localized pulmonary infiltrates limited to the middle or lower lung fields in 5 patients ( ... | 1985 | 3977176 |
| chronic cutaneous granulomatous dermopathy: morphologic and serologic evaluation, differential diagnosis and pharmacologic control. | we report on a syndrome of disfiguring lower extremity cutaneous lesions of 6 years duration. previous medical evaluations included 5 skin biopsies and several therapeutic regimens which did not alter the course of illness. the histologic interpretations of skin biopsies included panniculitis, papulonecrosis, and granuloma. one biopsy was interpreted as a localized cutaneous vasculitis with a wedge-shaped infarct. infectious, collagen vascular, and factitious etiologies could not be demonstrated ... | 1985 | 3980110 |
| tuberculosis presenting as carpal tunnel syndrome. | a 44-year-old man presented with typical symptoms, signs, and laboratory findings of carpal tunnel syndrome. mycobacterium tuberculosis was cultured from the flexor tenosynovium excised at surgery. tuberculosis should be considered in the differential diagnosis of carpal tunnel syndrome with unexplained chronic synovitis. the diagnosis may be missed unless a tissue specimen is analyzed specifically with acid-fast stain and culture. therapy should include excision of involved synovium, early post ... | 1985 | 3980938 |
| the bone marrow in disseminated mycobacterium avium-intracellulare infection. | thirteen cases of disseminated mycobacterium avium-intracellulare (mai), representing a total of 27 bone marrow specimens, were studied. the patients ranged from 25 to 46 years of age and included ten immunocompromised and three immunocompetent hosts. peripheral blood findings included anemia in all patients, leukopenia in 73%, thrombocytopenia in 45%, and pancytopenia in 45%. fourteen of the specimens (52%) showed granulomas ranging from small, subtle lymphohistiocytic aggregates to larger lymp ... | 1985 | 3984940 |
| solitary pulmonary nodule due to cryptococcus neoformans and mycobacterium tuberculosis. | this report describes a rare combined infection of cryptococcus neoformans and mycobacterium tuberculosis that manifested as a solitary pulmonary nodule in a nonimmunocompromised patient. transthoracic needle aspiration biopsy was initially nondiagnostic, and histopathologic and culture confirmation of the diagnosis was eventually attained after wedge resection of the nodule. an extensive review of the english literature failed to reveal any reported cases of such a combined infection with a sim ... | 1985 | 3985041 |
| isoniazid-resistant tuberculosis. a community outbreak and report of a rifampin prophylaxis failure. | the choice of effective preventive treatment for persons exposed to mycobacterium tuberculosis resistant to isoniazid is uncertain. although no data document the efficacy of any drug other than isoniazid for preventive treatment of tuberculosis, rifampin, with or without ethambutol, has been used for prophylaxis in contacts of cases with known isoniazid-resistant organisms. this report describes a community outbreak of isoniazid-resistant tuberculosis infection and a case of rifampin prophylaxis ... | 1985 | 3989958 |
| [the choice of antibiotics for prophylaxis of postoperative infections in the field of orthopaedics. clinical experience with cefoxitin]. | the clinical effects of cefoxitin (cfx) were evaluated in the prophylaxis of postoperative infections in the field of orthopaedics. the clinical response was good in 46 out of 50 patients; an efficacy rate of 92%. four patients (8%) who did not respond to cfx were suffering from infections due to mycobacterium tuberculosis (1), suspected pseudomonas aeruginosa (1), and infection of unknown organism (2). a review was also made of recent trends among clinically isolated bacterial strains and their ... | 1985 | 3989982 |
| cutaneous inoculation tuberculosis secondary to 'jailhouse tattooing'. | cutaneous inoculation tuberculosis is rare in the united states today. when seen, it usually occurs in individuals whose occupations or environments place them at increased risk for exposure to mycobacterium tuberculosis. the reaction of the skin to m tuberculosis infection is polymorphous and depends upon the interplay of bacterial virulence and host immunity. thus, both a high index of suspicion and positive cultures are required to make the diagnosis. herein, we report a case of cutaneous ino ... | 1985 | 3994412 |
| inhibition of mycobacteria by garlic extract (allium sativum). | thirty strains of mycobacteria, consisting of 17 species, were inhibited by various concentrations of garlic extract incorporated in middlebrook 7h10 agar. the concentration required ranged from a low of 1.34 mg/ml to a high of 3.35 mg/ml of media. when there were multiple strains of a species, a mean inhibitory concentration was determined for that species. six strains of mycobacterium tuberculosis required a mean inhibitory concentration of 1.67 mg/ml of media. | 1985 | 4004189 |
| tubulointerstitial nephritis induced in the brown norway rat with chaotropically solubilized bovine tubular basement membrane: the model and the humoral and cellular responses. | doses of as little as 50 micrograms of a soluble chaotropic extract of bovine tubular basement membrane (bov-kbr-tbm) with adjuvants induced anti-tbm antibodies and tubulointerstitial nephritis (tin) in brown norway (bn) rats. the lesion was shown by renal histology, by deposition of igg and c3 along tbm, and in terms of the humoral and cellular immune responses to compare to that produced by the standard immunization (particulate bovine tbm) for this model of tin in bn rats. more than half of t ... | 1985 | 4006324 |
| the increase of lipid peroxidation in rat adjuvant arthritis and its inhibition by superoxide dismutase. | adjuvant arthritis was induced in rats by the injection of mycobacterium tuberculosis, and its severity was scored according to the macroscopic findings of the legs, tail, and ears. the average score so obtained was lower in sod-injected rats than in the control group. the depression of albumin/globulin ratio was inhibited significantly in rats treated with 10.0 mg/kg of sod. the levels of acid phosphatase and beta-glucuronidase were elevated after the administration of an adjuvant, and these ly ... | 1985 | 4015632 |
| abdominal tuberculosis: ct evaluation. | the computed tomography (ct) scans of 27 patients with abdominal tuberculosis were reviewed retrospectively to determine the range of abdominal involvement. most patients had been at increased risk because of intravenous drug abuse, alcoholism, acquired immunodeficiency syndrome (aids), cirrhosis, or steroid therapy. the etiologic agent was mycobacterium tuberculosis in 23 patients and m. avium-intracellulare in four patients with aids. in five patients, tuberculosis was limited to the abdomen. ... | 1985 | 4034967 |
| tuberculin conversions in indochinese refugees. an assessment of boosting and anergy. | indochinese refugees entering the united states have a high rate of tuberculosis and tuberculin reactivity. in addition, several investigators have noted that a large number of refugees with initial tuberculin tests that are "not significant" change to "significant" reactions when retested within 8 wk. this "conversion" phenomenon has been reported in 21 to 43% of refugees and has been unexplained by antigen, testing, demographic, or exposure risk factors. a prospective evaluation of 218 refugee ... | 1985 | 4037526 |
| endometritis due to mycobacterium tuberculosis. | | 1985 | 4042038 |
| use of streptomycin and isoniazid during a tuberculosis epizootic in a rhesus and cynomolgus breeding colony. | an epizootic of tuberculosis occurred following the addition of new cynomolgus monkeys to a nonhuman primate breeding colony. a total of 5/47 cynomolgus and 51/148 rhesus became tuberculin positive (reactors). mycobacterium tuberculosis was cultured from reactors which were euthanatized and monkeys which died spontaneously. the isolates were sensitive to the standard antitubercular agents. rhesus reactors and their unweaned infants were quarantined and given streptomycin and isoniazid by intramu ... | 1985 | 4046550 |