| prevalence of agglutinins in canine serums to serotypes other than leptospira canicola and leptospira icterohaemorrhagiae; report of isolation of leptospira pomona from a dog. | | 1958 | 13498252 |
| a mild form of leptospirosis due to leptospira canicola; report of 3 cases in children. | | 1958 | 13556663 |
| leptospira canicola infection in a newborn calf. | | 1958 | 13583355 |
| amino acid utilization by leptospira canicola. | | 1959 | 13620644 |
| [leptospira canicola infections in dogs of a training school]. | | 1958 | 13624123 |
| [leptospira canicola infection of a febrile and meningeal form with uveitis]. | | 1961 | 13686973 |
| isolation of leptospira canicola from skunks in louisiana. | | 1961 | 13743811 |
| noninterference with immunity by a trivalent vaccine containing distemper virus, infectious canine hepatitus virus, and leptospira canicola. | | 1961 | 13788987 |
| the growth supporting factors of leptospira canicola in acetone-soluble egg yolk lipids. | | 1961 | 13935660 |
| leptospira canicola infection: report of 81 cases and review of the literature. | | 1963 | 13942625 |
| [leptospirosis canicola. apropos of a case with j aundice and meningeal manifestations]. | | 1962 | 13996867 |
| electron microscopy of the action of polymyxin on leptospirae. | | 1962 | 14017516 |
| leptospiral colonial morphology. | stalheim, o. h. v. (university of wisconsin, madison) and j. b. wilson. leptospiral colonial morphology. j. bacteriol. 86:482-489. 1963.-a sequence of apparent colonial types was observed with colonies of leptospira pomona, l. canicola, l. icterohaemorrhagiae, and l. grippotyphosa in agar medium. although some colonies of these serotypes had a different appearance initially, they eventually developed the mature or final appearance characteristic of the serotype. colonies of freshly isolated, vir ... | 1963 | 14066425 |
| anicteric leptospirosis. | | 1963 | 14071168 |
| growth of pathogenic leptospirae by replacing rabbit serum with mycobacterium phlei or mycobacterium smegmatis. | | 1963 | 14080790 |
| [leptospirosis canicola: verification of an outbreak occurring in a locality very close to s ao paulo (capital)]. | | 1963 | 14116859 |
| [cross infection experiments with virulent leptospirae of various pathogenic serotypes]. | | 1964 | 14174072 |
| [use of lyophilized korthofs medium in the cultivation of leptospira]. | | 1964 | 14183455 |
| antigenic similarity and immunobiological relationships between serotypes of the leptospirae, l. icterohaemorrhagiae and l. canicola. | | 1964 | 14184876 |
| comparative q fever investigations. i. q fever and related zoonoses in an endemic area. | | 1964 | 14200220 |
| [on leptospiral uveitis]. | | 1964 | 14207975 |
| canicola fever. | | 1965 | 14222558 |
| [new immunochemical research on leptospirosis. gamma globulin serum]. | | 1964 | 14236375 |
| differentiation of pathogenic and saprophytic leptospires with 8-azaguanine. | johnson, russell c. (university of minnesota, minneapolis), and palmer rogers. differentiation of pathogenic and saprophytic leptospires with 8-azaguanine. j. bacteriol. 88:1618-1623. 1964.-the use of the purine analogue, 8-azaguanine, as a differential agent for the separation of pathogenic and saprophytic leptospires was investigated. growth of strains of the saprophyte leptospira biflexa was almost insensitive to the bacteriostatic action of 8-azaguanine at concentrations varying from 25 to 6 ... | 1964 | 14244050 |
| the epidemiology of leptospirosis in north queensland. i. general surgery of animal hosts. | | 1964 | 14244080 |
| antileptospiral activity of normal serum. | | 1965 | 14291607 |
| the relation of animal hosts of parasitic leptospires in the netherlands with human leptospirosis. | | 1965 | 14317224 |
| studies on the development of antibodies in the serum of piglets experimentally infected by leptospira canicola. | | 1965 | 14331439 |
| further observations on abortion of the sow due to infection by leptospira canicola. | | 1965 | 14331480 |
| use of antibiotics in the preparation of canine kidney tissue culture vaccines to eliminate leptospiral infection hazards. | the potential leptospiral infection hazard in the use of vaccines prepared from canine kidney monolayer cultures was studied. cell cultures were prepared from kidneys of dogs experimentally infected with leptospira serotype canicola. viable leptospires were found in kidney cell suspensions at the time of seeding, surviving trypsinization either at room temperature for approximately 2 hr or overnight at 4 c, even in the presence of antibiotics. in tissue cultures maintained without antibiotics, l ... | 1965 | 14339267 |
| epizootiology of leptospirosis (canicola) in the bovine and other species in israel. | | 1955 | 14353767 |
| [protein-free culture solutions for leptospira canicola]. | | 1955 | 14360554 |
| [carriage of leptospira canicola by wild rats on sakhalin]. | | 1954 | 14360648 |
| [carriage of l. canicola in dogs in sakhalin]. | | 1955 | 14387208 |
| meningitis due to canicola fever. | | 1955 | 14392065 |
| [2 new serotypes belonging to the leptospira canicola group]. | | 1960 | 14448231 |
| safety of a modified-live combination vaccine against respiratory and reproductive diseases in pregnant cows. | a combination vaccine (bovi-shield fp4 + l5, pfizer animal health) containing modified-live virus (mlv) components against bovine herpesvirus-1 (bhv-1), bovine viral diarrhea virus bvdv), parainfluenza virus-3 (pi3), bovine respiratory syncytial virus (brsv), and inactivated cultures of leptospira canicola, grippotyphosa, hardjo, icterohaemorrhagiae, and pomona was evaluated for safety in pregnant beef and dairy animals. heifers vaccinated prebreeding with the minimum immunizing dose (lowest ant ... | 2003 | 14506587 |
| studies on the nutrition of leptospira canicola. | | 1950 | 14797783 |
| meningitis due to leptospira canicola. | | 1951 | 14821377 |
| leptospira canicola in a girl and her puppy. | | 1951 | 14843026 |
| renal lesions in leptospira canicola infection in dogs. | | 1952 | 14908795 |
| nutrition of leptospira canicola. ii. a chemically defined basal medium containing purified rabbit serum albumin. | | 1951 | 14912027 |
| cell aggregation: a mechanism of pathogenic leptospira to survive in fresh water. | transmission of leptospirosis is facilitated by the survival of pathogenic leptospires in moist environments outside their mammalian host. in the present study, the survival mechanisms of leptospira interrogans serovar canicola in aqueous conditions and lack of nutrients were investigated. in distilled water, leptospires were able to remain motile for 110 days (ph 7.2). however, when incubated in a semi-solid medium composed of distilled water and 0.5% purified agarose (ph 7.2), they survived 34 ... | 2004 | 15179605 |
| [human leptospira canicola infections with peculiar skin manifestations]. | | 1950 | 15419641 |
| leptospirosis; clinical appearance of the dog with disease caused by leptospira canicola with brief reference to diagnosis. | | 1950 | 15431491 |
| [acute leptospirosis in children in reunion island: a retrospective review of 16 cases]. | leptospirosis is a worldwide zoonosis caused by pathogenic species of the genus leptospira. this infectious disease known with a high incidence in reunion island (french overseas territories in indian ocean) is in state of endemia especially during rains season. | 2005 | 15994067 |
| a case of human leptospira canicola infection in new zealand. | | 1993 | 16031705 |
| effects of static magnetic field on growth of leptospire, leptospira interrogans serovar canicola: immunoreactivity and cell division. | the effects of the exposure of the bacterium, leptospira interrogans serovar canicola to a constant magnetic field with magnetic flux density from a permanent ferrite magnet=140+/-5 mt were studied. changes in leptospira cells after their exposure to the field were determined on the basis of changes in their growth behavior and agglutination immunoreactivity with a homologous antiserum using dark-field microscopy together with visual imaging. the data showed that the exposed leptospira cells hav ... | 2004 | 16233687 |
| enhancement of glutamic-pyruvic transaminase activity in leptospirae by addition of rabbit serum. | glutamic-pyruvic transaminase (gpt) in leptospirae was shown to have an optimal temperature of 30 c and ph 8.0. it was activated by cofactor pyridoxal phosphate, similar to gpt from other sources. however, gpt in all leptospirae, such as leptospira canicola, l. icterohaemorrhagiae, l. autumnalis, and l. biflexa, evidently had less activity even when pyridoxal phosphate was present, in comparison with the cultivable spirochete reiter treponeme and streptococcus faecalis. the low level of activity ... | 1970 | 16557719 |
| the influence of amino acids on the growth of leptospira canicola. | | 1945 | 16560974 |
| leptospirosis and panuveitis in a dog. | a case of panuveitis as a result of leptospiral infection in an 8-year-old jack russell terrier is reported. mild hyphema, aqueous flare, and partial serous retinal detachments were noted in both eyes on initial ophthalmic examination. the serum microscopic agglutination testing for leptospira serovarieties revealed titers of 1 : 12 800 for leptospira canicola and 1 : 200 for leptospira icterohemorrhagiae. with medical therapy, the panuveitis resolved and functional vision was regained. four wee ... | 2006 | 16634930 |
| evaluation of a rapid slide agglutination test for the diagnosis of acute canine leptospirosis. | the standard method for the diagnostic of leptospirosis is the microscopic agglutination test (mat). nevertheless, it is time-consuming and presents risk of infection for laboratory personal. several attempts to simplify and reduce the time, skill and expense required for serological testing were made. rapid slide agglutination tests (rsat) have been used nowadays as a reliable screening test for the detection of acute and recent infections by many laboratories. the purpose of that study was to ... | 2002 | 17061485 |
| evaluation of recombinant leptospira interrogans serovar canicola outer membrane proteins as diagnostic antigen. | | 2006 | 17185875 |
| immunoreactive outer membrane proteins of leptospira interrogans serovar canicola strain hond utrecht iv. | leptospirosis is a severe and complex zoonotic disease prevalent in many countries including india. current leptospiral research is focussed on the identification of the outer membrane proteins (omps) of the organism that could be used in developing diagnostic assays for leptospirosis. | 2006 | 17213526 |
| immunological properties of cellular and whole-culture leptospiral bacterins. | two bivalent leptospiral bacterins were compared for safety in guinea pigs and for potency in hamsters. one bacterin (bacterin a) was prepared from the cellular material of leptospiral icterohaemorrhagiae and leptospira canicola cultures propagated in stuart's modified medium with 7% rabbit serum. the 2nd bacterin (bacterin b) contained whole leptospiral cultures grown in synthetic medium. neither bacterin induced adverse local or systemic reactions when injected intraperitoneally (i/p) in guine ... | 1997 | 17216994 |
| serological titers to various leptospiral serovars before and after vaccinating gilts with three commercial vaccines. | the antibody response to various leptospiral serovars was evaluated in six-month-old gilts vaccinated with three commercial vaccines, each containing five leptospiral serovars.all three vaccines elicited a significant postvaccinal antibody response to leptospira canicola, grippotyphosa and icterohaemorrhagiae (copenhageni). the antibody response to the other leptospiral antigens in the vaccines varied among the vaccinates. none of the vaccinated groups developed significant titers to l. hardjo. ... | 1990 | 17423557 |
| canine leptospirosis infections - clinical signs and outcome with different suspected leptospira serogroups (42 cases). | the aim of the study was to investigate the presence of serum antibodies to different leptospira serogroups in dogs with a clinical diagnosis of leptospirosis in southern germany and to compare seroreactivity to different serogroups with history, clinical signs, laboratory findings and survival rate. | 2007 | 17490440 |
| serological investigations of leptospirosis in canada. ii. preliminary agglutination - lysis studies of cattle sera with leptospira pomona and leptospira canicola antigens. | | 1957 | 17648935 |
| the golden hamster (cricetus auratus) as a test animal for the diagnosis of leptospirosis. | there is evidence that the golden hamster (cricetus auratus) is the animal of choice for the isolation of leptospirae, especially of the leptospira canicola type since young guinea pigs and mice are resistant to infection and rats are entirely refractory. both the classical strain, l. icterohaemorrhagiae and l. canicola on isolation have been found to produce a fatal infection in hamsters. the present report deals with the isolation of l. canicola in two instances by the injection intraperitonea ... | 1944 | 17795954 |
| [solubilization of components of outer membrane of leptospira interrogans serovar mozdok by sodium desoxycholate and triton x-100 and evaluation of their immunogenic capacity and homologous and heterologous protection induced in hamsters]. | two detergents (triton x-100 and sodium desoxycholate) were evaluated as solubilizing agents of the components of the outer membrane of leptospira pomona serovar mozdok. it was obtained a greater yielding of proteins on applying the treatment with triton x-100. the variants formulated starting from the extracts obtained showed a high immunogenicity and capacity of homologous protection against the challenge in hamster. | 2005 | 17966480 |
| [seropositivity to leptospiras in sera from patients suspected of viral hepatitis negative to serological markers]. | the prevalence of leptospirosis found in icteric patients negative to serological markers for hepatitis was described. 15.99 % of them were positive patients. it was observed a predominance of serovars canicola, pomona and icterohaemorrhagiae. | 2005 | 17966482 |
| [evaluation of the vaccine potentiality of 2 strains from leptospira interrogans serogroup ballum]. | two vacine candidate strains from ballum serogroup were characterized and their immunogenicity and protective power were studied in hamster. the monovalent vaccine formulations obtained showed a high immunogenicity and capacity of homologous protection and, in a lesser degree, of cross protection. | 2005 | 17966485 |
| [use of diafiltration in the lavage of cultures of leptospira interrogans canicola canicola for the production of vaccine vax-spiral]. | it was proposed to substitute the present technology of the lavage operation for a tangential microfiltration system at the lavage stages of the culture of leptospira interrogans canicola canicola. it was proved that this system may be applied, since no cellular affectation was observed and high pollutant elimination levels were obtained. | 2005 | 17966488 |
| [scale-up of the fermentation of leptospira interrogans canicola canicola for the production of vax-spiral vaccine]. | the operational conditions for the production of vaccine vax-spiral were established at the scale of 100 l. it was concluded that it should be carried out with an air flow of 10 l/min (0.1 vvm) and without mechanical agitation. | 2005 | 17966489 |
| [not available]. | | 1948 | 18862509 |
| four cases of leptospira canicola infection in england. | | 1948 | 18870103 |
| penicillin in leptospira canicola infection in the dog. | | 1947 | 18918621 |
| onset and duration of protective immunity against clinical disease and renal carriage in dogs provided by a bi-valent inactivated leptospirosis vaccine. | protection against clinical disease and prevention of the renal carrier state remain the key objectives of vaccination against leptospirosis in the dog. in the present paper, groups of dogs were vaccinated twice with a commercial bacterin (eurican l) containing leptospira interrogans serovars icterohaemorrhagiae and canicola and challenged with heterologous representatives of both serovars at 2 weeks (onset of immunity) or 14 months (duration of immunity) after the second vaccination. control do ... | 2009 | 19179023 |
| occurrence of leptospirosis among suspected cases in chennai, tamil nadu. | to evaluate the serological profile of leptospirosis by microscopic agglutination test (mat) and dark field microscopy (dfm) and to determine the serovar prevalence rate among patients with pyrexia of unknown origin. | 2011 | 21393887 |
| pharmacovigilance in veterinary medicine in chile: a pilot study. | irag++en, d., urcelay, s., san mart+¡n, b. pharmacovigilance in veterinary medicine in chile: a pilot study. j. vet. pharmacol. therap.34, 108-115. in chile, there is no present government policy to survey and analyse adverse drug reactions (adrs) in the field of veterinary medicine. the intent of this study is to assess, for the first time, adr frequency in treated animals. to this purpose, a 6-month period pilot study based on who recommendations was conducted to monitor adrs in cats and dogs ... | 2011 | 21395600 |
| [response of antileptospira igg antibodies in individuals immunized with vax-spiral]. | a quantitative elisa for the detection of igg antibodies in response to the cuban vaccine against the human leptospirosis (vax-spiral) was applied to 930 volunteers'sera, 483 immunized with vax-spiral and 447 with a vaccine against hepatitis b. samples were taken before beginning the study, 21 days after the second dose and a year later. a high seroprevalence of antibodies to the vaccine serovars was observed before beginning the study. the initial value of the response doubled at 21 days of the ... | 2005 | 17966473 |
| [development of a method to determine the minimum inhibitory concentration in reference strains from leptospiras]. | a method to determine the minimum inhibitory concentration for leptospiras was developed, since there is not a standard method to measure it at the international level. reference strains from the pathogenic complex l. interrogans and l. biflexa were used against penicillin, cyprofloxacine, chloramphenicol, rifampicine and tetracycline. the minimum inhibitory concentration was defined as the lowest concentration of antibiotic where it was observed the inhibition of the bacterial mobility by direc ... | 2005 | 17966469 |
| cloning and sequencing of a 21 kda outer membrane protein gene of leptospira interrogans serovar canicola strain hond utrecht iv. | | 2007 | 17221364 |
| evaluation of a recombinant lipl41 antigen of leptospira interrogans serovar canicola in elisa for serodiagnosis of bovine leptospirosis. | the efficacy of a recombinant leptospiral lipoprotein lipl41 as an antigen for conducting enzyme-linked immunosorbent assay (elisa) for diagnosis of bovine leptospirosis was evaluated. using known positive and known negative cattle sera the recombinant antigen was found to be highly reactive in the concentration of 100 ng/well. using a total of 321 field cattle sera the sensitivity of elisa as compared to microscopic agglutination test (mat) was calculated to be 100% whereas the specificity was ... | 2006 | 16979238 |
| [immunogenicity and protective capacity of leptospiral whole-cell monovalent serogroup ballum vaccines in hamsters]. | leptospira serogroup ballum is at present the first cause of human leptospirosis in cuba. killed whole-cell vaccines were formulated with two clinical isolates of leptospira interrogans serogroup ballum using aluminum hydroxide as adjuvant. agglutinins levels induced by each vaccine in hamsters were estimated by microscopic agglutination test and specific igg activities were quantified by a whole cell-based enzyme-linked immunosorbent assay. homologous and cross protective capacity against letha ... | 2005 | 16502635 |
| [eye disturbances due to leptospira canicola]. | | 1962 | 14481450 |
| [studies on the growth factor of leptospirae in egg-yolk lipid fraction]. | | 1962 | 14473604 |
| cultivation of leptospirae. i. nutrition of leptospira canicola. | stalheim, o. h. v. (university of wisconsin, madison), and j. b. wilson. cultivation of leptospirae. i. nutrition of leptospira canicola. j. bacteriol. 88:48-54. 1964.-the nutrition of leptospira canicola was investigated by use of synthetic media of suitable ionic strength. at an incubation temperature of 30 c, the minimal components were calcium, iron, magnesium, and ammonium ions, thiamine, and a fatty acid source; barium and strontium replaced calcium. aspartic acid, glutamic acid, or methio ... | 1964 | 14197904 |
| evaluation of a recombinant ligb protein of leptospira interrogans serovar canicola in an enzyme-linked immunosorbent assay for the serodiagnosis of bovine leptospirosis. | a recombinant leptospiral lipoprotein, ligb, was evaluated for use in the diagnosis of bovine leptospirosis by enzyme-linked immunosorbent assay (rligb igg elisa). the standard reference test (microscopic agglutination test, mat) of 200 serum samples from cattle suspected of leptospirosis showed that 95 (47.5%) samples had positive agglutination titres, which ranged from 100 to 1600. in rligb igg elisa, 49% of the samples were positive. sensitivity of igg elisa for 95 bovine sera, which had mat ... | 2010 | 20022618 |