| annual variation in the plasma testosterone in microcebus murinus. | | 1981 | 7319422 |
| further observations on the occurrence of taste buds in the papilla palatina of primates. | 1. taste buds occur in the epithelium of the papilla of galago crassicaudatus and demidovi, perodicticus potto and microcebus murinus. the taste buds are found single or in groups of 2 or 3. a taste area ocurs in galago crassicaudatus and perodicticus potto. 2. the pattern of the distribution of the taste buds in the species studied is basically the same as found previously in nycticebus and tupaia. the taste buds are found in the oral part of the papilla palatina exclusively, far oral to the or ... | 1980 | 7429132 |
| [influence of social grouping on seasonal sexual activation in male microcebus murinus (miller 1777)]. | comparative studies were made on different heterosexual groups of microcebus murinus during the period of sexual activation, which is determined by the photoperiod. in pairs (1 male--1 female), the sexual activation of the males occurs during january. this is accompanied by a loss of body weight and by an increase in basal oxygen consumption. the testes are maximal in size by the beginning of march. in groups of 8 individuals (4 males--4 females) only one male exhibits normal sexual activity. he ... | 1977 | 404781 |
| [observations on reproduction of microcebus murinus (miller 1777) in captivity at tananarive]. | | 1974 | 4448303 |
| [the cycle of the seminiferous epithelium of microcebus murinus (miller, 1777)]. | | 1974 | 4448302 |
| [application of semestrial photoperiodism to microcebus murinus (miller 1777)]. | | 1972 | 4677464 |
| [the corticotropic cells in the hypophysis of a madagascan lemur: microcebus murinus (miller, 1777). identification by immunofluorescence]. | | 1971 | 4104037 |
| [histological and comparative anatomical studies on the ontogenesis and phylogenesis of the hand skeleton of tupaia glis (diard 1820) and microcebus murinus (j.f. miller 1777)]. | | 1971 | 5134621 |
| [sexual periodicity of the female of a lower primate, the lemur microcebus murinus; effect of transposition of seasonal changes in light]. | | 1959 | 13663408 |
| isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian genera. | stem cell-based therapies are an attractive option to promote regeneration and repair defective tissues and organs. thanks to their multipotency, high proliferation rate and the lack of major ethical limitations, "olfactory ecto-mesenchymal stem cells" (oe-mscs) have been described as a promising candidate to treat a variety of damaged tissues. easily accessible in the nasal cavity of most mammals, these cells are highly suitable for autologous cell-based therapies and do not face issues associa ... | 2018 | 29343270 |
| a comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and grey mouse lemur (microcebus murinus). | the adult brain contains niches of neural stem cells that continuously add new neurons to selected circuits throughout life. two niches have been extensively studied in various mammalian species including humans, the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampal dentate gyrus. recently, studies conducted mainly in rodents have identified a third neurogenic niche in the adult hypothalamus. in order to evaluate whether a neural stem cell niche also exist ... | 2017 | 29230807 |
| genome-wide mining of perfect microsatellites and tetranucleotide orthologous microsatellites estimates in six primate species. | advancement in genome sequencing and in silico mining tools have provided new opportunities for comparative primate genomics of microsatellites. the ssrs (simple sequence repeats) numbers were not correlated with the genome size (pearson, r=0.310, p=0.550), and were positively correlated with the total length of ssrs (pearson, r=0.992, p=0.00). a total of 224,289 tetranucleotide orthologous microsatellites families and 367 single-copy orthologous ssrs loci were found in six primate species by ho ... | 2018 | 29223358 |
| a novel translational model of spinal cord injury in nonhuman primate. | spinal cord injuries (sci) lead to major disabilities affecting > 2.5 million people worldwide. major shortcomings in clinical translation result from multiple factors, including species differences, development of moderately predictive animal models, and differences in methodologies between preclinical and clinical studies. to overcome these obstacles, we first conducted a comparative neuroanatomical analysis of the spinal cord between mice, microcebus murinus (a nonhuman primate), and humans. ... | 2017 | 29181770 |
| sensory island task (sit): a new behavioral paradigm to study sensory perception and neural processing in freely moving animals. | a central function of sensory systems is the gathering of information about dynamic interactions with the environment during self-motion. to determine whether modulation of a sensory cue was externally caused or a result of self-motion is fundamental to perceptual invariance and requires the continuous update of sensory processing about recent movements. this process is highly context-dependent and crucial for perceptual performances such as decision-making and sensory object formation. yet desp ... | 2020 | 33100981 |
| effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (microcebus murinus). | the development of novel therapeutics to prevent cognitive decline of alzheimer's disease (ad) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. currently approved treatments, including the acetylcholinesterase inhibitor donepezil (don) and the n-methyl-d-aspartate antagonist memantine (mem) provide marginal therapeutic benefits to ad patients. there is an urgent need to develop a predictive animal model that is phylog ... | 2017 | 28922421 |
| an analysis of birth sex ratio bias in captive prosimian species. | the extent to which sex ratio bias is a common reproductive characteristic of prosimians has not been well established. the present study analyzed reproduction in 13 breeding groups of captive prosimians for evidence of birth sex ratio bias. a substantial male bias was demonstrated in nongregarious, but not gregarious, breeding groups. analyses of birth sex ratios of individual mothers suggested that the observed bias did not result from the tendency of a few mothers to overproduce males, but ra ... | 1996 | 31918482 |
| the lemur baseline: how lemurs compare to monkeys and apes in the primate cognition test battery. | primates have relatively larger brains than other mammals even though brain tissue is energetically costly. comparative studies of variation in cognitive skills allow testing of evolutionary hypotheses addressing socioecological factors driving the evolution of primate brain size. however, data on cognitive abilities for meaningful interspecific comparisons are only available for haplorhine primates (great apes, old- and new world monkeys) although strepsirrhine primates (lemurs and lorises) ser ... | 2020 | 33024643 |
| instrumental problem-solving abilities in three lemur species (microcebus murinus, varecia variegata, and lemur catta). | apes and some new and old world monkeys (i.e., haplorhine primates) are known to routinely use tools. in strepsirrhine primates (i.e., lemurs and lorises), no tool use has been reported, even though they appear to have some basic understanding of the spatial relations required for using a pulling tool. to facilitate direct comparisons of the underlying abilities between haplorhine and strepsirrhine primate species, we experimentally examined instrumental problem-solving abilities in three captiv ... | 2018 | 30080072 |
| captive dwarf and mouse lemurs have variable fur growth. | researchers typically assume constant fur and hair growth for primates, but the few studies that have investigated growth explicitly suggest this may not be the case. instead, growth may vary considerably among individuals and across seasons. one might expect this variability to be most pronounced for species that have seasonally variable activity patterns (e.g., madagascar's cheiorogaleidae). in particular, dwarf lemurs (cheirogaleus spp.) undergo considerable changes in their daily activity le ... | 2020 | 32731532 |
| occurrence of lemurs in landscapes and their species-specific scale responses to habitat loss. | studies on the impact of habitat loss on species occurrence consistently find that the amount of habitat (measured as patch area) is a major determinant of species occurrence at a patch-level. however, patch-level research may fail to detect important patterns and processes only observable at a landscape-level. a landscape-level approach that incorporates species-specific scale responses is needed to better understand what drives species occurrence. our aim was to determine the landscape-level s ... | 2020 | 32083335 |
| navigation strategies in three nocturnal lemur species: diet predicts heuristic use and degree of exploratory behavior. | humans generally solve multi-destination routes with simple rules-of-thumb. animals may do the same, but strong evidence is limited to a few species. we examined whether strepsirrhines, who diverged from haplorhines more than 58 mya, would demonstrate the use of three heuristics used by humans and supported in vervets, the nearest neighbor rule, the convex hull, and a cluster strategy, when solving a multi-destination route. we hypothesized that the evolution of these strategies may depend on a ... | 2019 | 30758804 |
| lemur species-specific metapopulation responses to habitat loss and fragmentation. | determining what factors affect species occurrence is vital to the study of primate biogeography. we investigated the metapopulation dynamics of a lemur community consisting of eight species (avahi occidentalis, propithecus coquereli, microcebus murinus, microcebus ravelobensis, lepilemur edwardsi, cheirogaleus medius, eulemur mongoz, and eulemur fulvus) within fragmented tropical dry deciduous forest habitat in ankarafantsika national park, madagascar. we measured fragment size and isolation of ... | 2018 | 29742108 |
| reproduction in coquerel's dwarf lemur (mirza coquereli). | most nocturnal malagasy primates, as well as many diurnal species, are highly endangered in their natural habitat. captive breeding programs have been established for many species, but detailed information on reproduction is only available for three nocturnal taxa: the mouse lemur (microcebus murinus), the dwarf lemur (cheirogaleus medius), and the greater dwarf lemur (cheirogaleus major). in this study, we present data for another nocturnal malagasy primate, coquerel's dwarf lemur (mirza coquer ... | 1995 | 31924095 |
| description of ultrasonic vocalizations of the mouse lemur (microcebus murinus) and the fat-tailed dwarf lemur (cheirogaleus medius). | ultrasonic (>20 khz) vocalizations were recorded from two species of prosimian primates, microcebus murinus and cheirogaleus medius. three types of ultrasonic calls were emitted by isolated or paired m. murinus: 1) "chirps," short-duration (30 msec) calls with a sharp onset at 40 khz followed by rapid and steep declines in frequency and intensity; 2) "twitters," characterized by a brief pulse at 25 khz prior to the onset of repeating, frequency-modulated units; and 3) "long whistles," monotone s ... | 1987 | 31973475 |
| highly repeated dna sequences as phylogenetic markers among the galaginae. | highly repeated dna sequences were investigated as potential phylogenetic indicators among five species of galagines. one lorisine, one cheirogaleid, and two lemurid species were also investigated as progressively more distant outgroups. the lorisids displayed strong conservatism with regard to these sequences, to the point where the galegine species proved difficult to differentiate. when restriction fragment differences were observed, the galagine species fell into two groups: one containing t ... | 1994 | 31936921 |
| does calorie restriction in primates increase lifespan? revisiting studies on macaques (macaca mulatta) and mouse lemurs (microcebus murinus). | the effects of calorie restriction have now been studied in two non-human primates, the macaque macaca mulatta and the mouse lemur microcebus murinus. the study on lemurs and one of the two studies on macaques have reported a lifespan increase. in this review, i argue that these results are better explained by a lifespan decrease in the control group because of a bad diet and/or overfeeding, rather than by a real lifespan increase in calorie-restricted animals. if these results can be readily tr ... | 2018 | 30067295 |
| unique case of granulomatous arteritis in a grey mouse lemur (microcebus murinus) - first case description. | overall, diseases of the vascular system are rarely observed entities among nonhuman primates that are commonly associated with systemic infections, septicemia or bacteremia. rhesus monkeys infected with simian immunodeficiency virus (siv) may develop a chronic occlusive arteriopathy of unknown etiology in late stages of the disease. this siv associated arteriopathy is the only well-known specific vascular entity described in nonhuman primates. we herein report a unique case of granulomatous art ... | 2017 | 32110694 |
| age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies. | executive function (ef) is a complex construct that reflects multiple higher-order cognitive processes such as planning, updating, inhibiting and set-shifting. decline in these functions is a hallmark of cognitive ageing in humans, and age differences and changes in ef correlate with age-related differences and changes in association cortices, particularly the prefrontal areas. here, we review evidence for age-related decline in ef and associated neurobiological changes in prosimians, new world ... | 2020 | 32951543 |
| linking cognition to age and amyloid-β burden in the brain of a nonhuman primate (microcebus murinus). | the gray mouse lemur (microcebus murinus) is a valuable model in research on age-related proteopathies. this nonhuman primate, comparable to humans, naturally develops tau and amyloid-β proteopathies during aging. whether these are linked to cognitive alterations is unknown. here, standardized cognitive testing in pairwise discrimination and reversal learning in a sample of 37 aged (>5 years) subjects was combined with tau and amyloid-β histochemistry in individuals that died naturally. correlat ... | 2020 | 32650184 |
| sex-specific patterns of age-related cerebral atrophy in a nonhuman primate microcebus murinus. | steadily aging populations result in a growing need for research regarding age-related brain alterations and neurodegenerative pathologies. by allowing a good translation of results to humans, nonhuman primates, such as the gray mouse lemur microcebus murinus, have gained attention in this field. our aim was to examine correlations between atrophy-induced brain alterations and age, with special focus on sex differences in mouse lemurs. for cerebral volumetric measurements, in vivo magnetic reson ... | 2020 | 32229027 |
| strengths and weaknesses of the gray mouse lemur (microcebus murinus) as a model for the behavioral and psychological symptoms and neuropsychiatric symptoms of dementia. | to face the load of the prevalence of alzheimer's disease in the aging population, there is an urgent need to develop more translatable animal models with similarities to humans in both the symptomatology and physiopathology of dementia. due to their close evolutionary similarity to humans, non-human primates (nhps) are of primary interest. of the nhps, to date, the gray mouse lemur (microcebus murinus) has shown promising evidence of its translatability to humans. the present review reports the ... | 2019 | 31736761 |
| a 3d population-based brain atlas of the mouse lemur primate with examples of applications in aging studies and comparative anatomy. | the gray mouse lemur (microcebus murinus) is a small prosimian of growing interest for studies of primate biology and evolution, and notably as a model organism of brain aging. as brain atlases are essential tools for brain investigation, the objective of the current work was to create the first 3d digital atlas of the mouse lemur brain. for this, a template image was constructed from in vivo magnetic resonance imaging (mri) data of 34 animals. this template was then manually segmented into 40 c ... | 2019 | 30326295 |
| caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates. | the health benefits of chronic caloric restriction resulting in lifespan extension are well established in many short-lived species, but the effects in humans and other primates remain controversial. here we report the most advanced survival data and the associated follow-up to our knowledge of age-related alterations in a cohort of grey mouse lemurs (microcebus murinus, lemurid primate) exposed to a chronic moderate (30%) caloric restriction. compared to control animals, caloric restriction ext ... | 2018 | 30271916 |
| first comparative approach to touchscreen-based visual object-location paired-associates learning in humans (homo sapiens) and a nonhuman primate (microcebus murinus). | a recent study suggests that a specific, touchscreen-based task on visual object-location paired-associates learning (pal), the so-called different pal (dpal) task, allows effective translation from animal models to humans. here, we adapted the task to a nonhuman primate (nhp), the gray mouse lemur, and provide first evidence for the successful comparative application of the task to humans and nhps. young human adults reach the learning criterion after considerably less sessions (one order of ma ... | 2018 | 29745681 |
| plasma amyloid is associated with white matter and subcortical alterations and is modulated by age and seasonal rhythms in mouse lemur primates. | accumulation of amyloid-β (aβ) peptides in the brain is a critical early event in the pathogenesis of alzheimer's disease (ad), the most common age-related neurodegenerative disorder. there is increasing interest in measuring levels of plasma aβ since this could help in diagnosis of brain pathology. however, the value of plasma aβ in such a diagnosis is still controversial and factors modulating its levels are still poorly understood. the mouse lemur (microcebus murinus) is a primate model of ce ... | 2018 | 29491833 |
| effects of n-3 polyunsaturated fatty acid supplementation on cognitive functions, electrocortical activity and neurogenesis in a non-human primate, the grey mouse lemur (microcebus murinus). | among environmental factors that may affect on brain function, some nutrients and particularly n-3 polyunsaturated fatty acids (n-3 pufa) are required for optimal brain development. their effects on cognitive functions, however, are still unclear, and studies in humans and rodents have yielded contradictory results. we used a non-human primate model, the grey mouse lemur, phylogenetically close to human. the aim of this study was to demonstrate the impact of n-3 pufa supplementation on cognitive ... | 2018 | 29486268 |
| a review on ocular findings in mouse lemurs: potential links to age and genetic background. | mouse lemurs, the world's smallest primates, inhabit forests in madagascar. they are nocturnal, arboreal and dependent on vision for their everyday lives. in the last decades, the grey mouse lemur became increasingly important for biomedical research, in particular aging research. experiments which require the combination of visual fitness and old age consequently depend on a solid knowledge of ocular pathologies. although ocular diseases in mouse lemurs have been described as being common, they ... | 2017 | 32110707 |
| sex-specific response to caloric restriction after reproductive investment in microcebus murinus: an integrative approach. | in seasonal environments, males and females usually maintain high metabolic activity during the whole summer season, exhausting their energy reserves. in the global warming context, unpredictability of food availability during summer could dramatically challenge the energy budget of individuals. therefore, one can predict that resilience to environmental stress would be dramatically endangered during summer. here, we hypothesized that females could have greater capacity to survive harsh conditio ... | 2020 | 32612534 |
| the art of growing old: environmental manipulation, physiological rhythms, and the advent of microcebus murinus as a primate model of aging. | in the early 1990s, microcebus murinus, a small primate endemic to madagascar, emerged as a potential animal model for the study of aging and alzheimer's disease. this paper traces the use of the lesser mouse lemur in research on aging and associated neurodegenerative diseases, focusing on a basic material precondition that made this possible, namely, the conversion of a wild animal into an experimental organism that lives, breeds, and survives in the laboratory. it argues that the "old" mouse l ... | 2020 | 32529381 |
| ontogeny of locomotion in mouse lemurs: implications for primate evolution. | the environment of juvenile primates is very challenging. they have to forage and move on the same substrates as adults do and escape the same predators, despite their immature state. in this study, we explore the developmental strategies that may provide effective locomotor abilities early in life. this could provide new insights into the selective pressures acting on juvenile primates and into evolution of primate locomotion. we conducted an ontogenetic study of 36 arboreal gray mouse lemurs f ... | 2020 | 32172006 |
| profiling torpor-responsive micrornas in muscles of the hibernating primate microcebus murinus. | when food scarcity is coupled with decreased temperatures, gray mouse lemurs (microcebus murinus) depress their metabolic rates and retreat into bouts of either daily torpor or multi-day hibernation, without dramatically dropping body temperatures like other 'traditional hibernators'. rapid and reversible mechanisms are required to coordinate the simultaneous suppression of energetically expensive processes and activation of pro-survival pathways critical for successful torpor-arousal cycling. m ... | 2020 | 31837470 |
| heritability and genetic correlations of personality, life history and morphology in the grey mouse lemur (microcebus murinus). | the recent interest in animal personality has sparked a number of studies on the heritability of personality traits. yet, how the sources variance these traits can be decomposed remains unclear. moreover, whether genetic correlations with life-history traits, personality traits and other phenotypic traits exist as predicted by the pace-of-life syndrome hypothesis remains poorly understood. our aim was to compare the heritability of personality, life-history and morphological traits and their pot ... | 2019 | 31824694 |
| an empirical estimate of the generation time of mouse lemurs. | the generation time of organisms drives the rate of change in populations and across evolutionary times. in long-lived species, generation time should also account for overlapping generations, and the average age of parents has been proposed as a best approximation under these conditions. this study uses this definition to estimate the generation time of a widely studied small primate, microcebus murinus, based on parentage data generated for a free-living population over a 6-year period in nort ... | 2019 | 31631370 |
| daily torpor and sleep in a non-human primate, the gray mouse lemur (microcebus murinus). | daily torpor is an energy-saving process that evolved as an extension of non-rapid eye movement (nrem) sleep mechanisms. in many heterothermic species there is a relation between torpor expression and the repartition of the different behavioral states of sleep. despite the presence of sleep during this period of hypothermia, torpor induces an accumulation of sleep debt which results in a rebound of sleep in mammals. we aimed to investigate the expression of sleep-wake rhythms and delta waves dur ... | 2019 | 31616258 |
| the ontogeny of masticatory muscle architecture in microcebus murinus. | the masticatory apparatus has been the focus of many studies in comparative anatomy-especially analyses of skulls and teeth, but also of the mandibular adductor muscles which are responsible for the production of bite force and the movements of the mandible during food processing and transport. the fiber architecture of these muscles has been correlated to specific diets (e.g., prey size in felids) and modes of foraging (e.g., tree gouging in marmosets). despite the well-elucidated functional im ... | 2020 | 31509342 |
| the forearm musculature of the gray mouse lemur (microcebus murinus): an ontogenetic study. | although studies have sought to characterize variation in forearm muscular anatomy across the primate order, none have attempted to quantify ontogenetic changes in forearm myology within a single taxon. herein, we present muscle architecture data for the forearm musculature (flexors and extensors of the wrist and digits) of microcebus murinus, a small lemuroid that has been the focus of several developmental studies. a quadratic curvilinear model described ontogenetic changes in muscle mass and ... | 2020 | 31509327 |
| encephalopathy induced by alzheimer brain inoculation in a non-human primate. | alzheimer's disease is characterized by cognitive alterations, cerebral atrophy and neuropathological lesions including neuronal loss, accumulation of misfolded and aggregated β-amyloid peptides (aβ) and tau proteins. iatrogenic induction of aβ is suspected in patients exposed to pituitary-derived hormones, dural grafts, or surgical instruments, presumably contaminated with aβ. induction of aβ and tau lesions has been demonstrated in transgenic mice after contamination with alzheimer's disease b ... | 2019 | 31481130 |
| a new species of schoutedenichia jadin & vercammen-grandjean, 1954 from madagascar and a re-description of s. dutoiti (radford, 1948) from south africa (acariformes: trombiculidae). | a new chigger mite species, schoutedenichia microcebi n. sp. is described from the grey mouse lemur microcebus murinus (j.f. miller) from madagascar. the new species is closely related to s. dutoiti (radford, 1948), a species described from a single specimen collected on a rodent in south africa. examination of the holotype and new material on s. dutoiti from south africa enabled us to re-describe this species and provide new data on its hosts and geographical distribution. | 2019 | 31452131 |
| hygienic personalities in wild grey mouse lemurs vary adaptively with sex. | detecting the risk of infection and minimizing parasite exposure represent the first lines of host defence against parasites. individuals differ in the expression of these behavioural defences, but causes of such variation have received little empirical attention. we therefore experimentally investigated the effects of several individual and environmental factors on the expression level of faecal avoidance in the context of feeding, drinking, sleeping and defecating in a wild primate population. ... | 2019 | 31387505 |
| the biological clock in gray mouse lemur: adaptive, evolutionary and aging considerations in an emerging non-human primate model. | circadian rhythms, which measure time on a scale of 24 h, are genetically generated by the circadian clock, which plays a crucial role in the regulation of almost every physiological and metabolic process in most organisms. this review gathers all the available information about the circadian clock in a small malagasy primate, the gray mouse lemur (microcebus murinus), and reports 30 years data from the historical colony at brunoy (france). although the mouse lemur has long been seen as a "primi ... | 2019 | 31447706 |
| differences in infection patterns of vector-borne blood-stage parasites of sympatric malagasy primate species (microcebus murinus, m. ravelobensis). | the dynamic relationship of vector-borne parasites, arthropod vectors and their hosts is prone to change under the influence of climate change, global integration, shifting demographics and deforestation. it is therefore essential to better understand parasitism in wildlife populations, including parasites transmitted by blood-feeding vectors, and explore host range and heterogeneity of parasitic infections. we investigated giemsa stained blood smears of two sympatric malagasy primate species (m ... | 2019 | 31372336 |
| female reproduction bears no survival cost in captivity for gray mouse lemurs. | the survival cost of reproduction has been revealed in many free-ranging vertebrates. however, recent studies on captive populations failed to detect this cost. theoretically, this lack of survival/reproduction trade-off is expected when resources are not limiting, but these studies may have failed to detect the cost, as they may not have fully accounted for potential confounding effects, in particular interindividual heterogeneity. here, we investigated the effects of current and past reproduct ... | 2019 | 31236213 |
| litter sex composition affects first reproduction in female grey mouse lemurs (microcebus murinus). | conditions during early development can have long-lasting consequences on behavioural phenotypes, reproduction and survival. we studied the consequences of maternal characteristics and litter sex composition on the reproductive fitness of 849 females during their first reproductive season in a captive population of mouse lemurs. in this primate, litters usually comprise 1 to 3 offspring. for female offspring, body mass at birth or at weaning did not depend on the parity of the mother but was str ... | 2019 | 31176643 |
| forest edges affect ectoparasite infestation patterns of small mammalian hosts in fragmented forests in madagascar. | habitat loss and fragmentation drive the worldwide depletion of biodiversity. although it is known that anthropogenic disturbances severely affect host and ecosystem integrity, effects on parasites are largely understudied. this study aims to investigate if and how habitat fragmentation affects the composition of ectoparasite communities on small mammalian hosts in two networks of dry deciduous forest fragments in northwestern madagascar. forest sites differing in size, proportion of edge habita ... | 2020 | 32224123 |
| ecological fragmentation effects in mouse lemurs and small mammals in northwestern madagascar. | habitat loss and fragmentation are major ecological forces threatening animal communities across the globe. these issues are especially true in madagascar, where forest loss is ongoing. we examined the effects of forest fragmentation on the distribution and abundance of sympatric, endemic gray, and golden-brown mouse lemurs (microcebus murinus and microcebus ravelobensis), the endemic western tuft-tailed rat (eliurus myoxinus), and the invasive black rat (rattus rattus) in two regions in northwe ... | 2020 | 31608491 |
| survival is reduced when endogenous period deviates from 24 h in a non-human primate, supporting the circadian resonance theory. | circadian rhythms are ubiquitous attributes across living organisms and allow the coordination of internal biological functions with optimal phases of the environment, suggesting a significant adaptive advantage. the endogenous period called tau lies close to 24 h and is thought to be implicated in individuals' fitness: according to the circadian resonance theory, fitness is reduced when tau gets far from 24 h. in this study, we measured the endogenous period of 142 mouse lemurs (microcebus muri ... | 2020 | 33093578 |
| experimental evaluation of spontaneous olfactory discrimination in two nocturnal primates (microcebus murinus and m. lehilahytsara). | solitary species often employ chemocommunication to facilitate mate localization. in the solitarily foraging, nocturnal mouse lemurs (microcebus spp.), females advertise their short period of estrus acoustically and by increased scent marking, whereas males search widely for receptive females. both sexes can be trained by operant conditioning to discriminate conspecific from heterospecific urine scent. however, it is not known, if males during and outside the reproductive season show different s ... | 2020 | 32710747 |
| physiological and cognitive consequences of a daily 26 h photoperiod in a primate: exploring the underlying mechanisms of the circadian resonance theory. | the biological clock expresses circadian rhythms, whose endogenous period (tau) is close to 24 h. daily resetting of the circadian clock to the 24 h natural photoperiod might induce marginal costs that would accumulate over time and forward affect fitness. it was proposed as the circadian resonance theory. for the first time, we aimed to evaluate these physiological and cognitive costs that would partially explain the mechanisms of the circadian resonance hypothesis. we evaluated the potential c ... | 2020 | 32693726 |
| neurobiological substrates of animal personality and cognition in a nonhuman primate (microcebus murinus). | the gray mouse lemur (microcebus murinus) is an important nonhuman primate model in biomedical research. numerous studies investigated mouse lemur behavior and possible factors underlying interindividual variation in both, animal personality and cognitive performance. some effects, such as an age-related decline in executive functioning, have robustly been found across laboratory colonies; however, little is known about the brain structural substrates in mouse lemurs. | 2020 | 32683780 |
| are generalists more innovative than specialists? a comparison of innovative abilities in two wild sympatric mouse lemur species. | the propensity to flexibly innovate behavioural variants might advantage animals when dealing with novel or modified ecological or social challenges. interspecific innovative abilities can be predicted by the degree of ecological generalism and intraspecific variation is predicted by personality traits. to examine the effects of these factors on innovation, we compared problem-solving abilities in the generalist grey mouse lemurs (microcebus murinus) and the more specialized madame berthe's mous ... | 2018 | 30225037 |
| linking cognition with fitness in a wild primate: fitness correlates of problem-solving performance and spatial learning ability. | linking the cognitive performance of wild animals with fitness consequences is crucial for understanding evolutionary processes that shape individual variation in cognition. however, the few studies that have examined these links revealed differing relationships between various cognitive performance measures and fitness proxies. to contribute additional comparative data to this body of research, we linked individual performance during repeated problem-solving and spatial learning ability in a ma ... | 2018 | 30104438 |
| identification of novel and conserved microrna and their expression in the gray mouse lemur, microcebus murinus, a primate capable of daily torpor. | microrna (mirna) are endogenous small noncoding rna gene products, on average 22 nt long, that play important regulatory roles in mediating gene expression by binding to and targeting mrnas for degradation or translational repression. in this paper we identify both novel and conserved mirna sequences present in the genome of the gray mouse lemur, microcebus marinus. in total, 122 conserved and 44 novel mirna were identified with high confidence from the lemur genome (mmur_2.0) and were used for ... | 2018 | 30103007 |
| ectoparasite communities of small-bodied malagasy primates: seasonal and socioecological influences on tick, mite and lice infestation of microcebus murinus and m. ravelobensis in northwestern madagascar. | ectoparasitic infections are of particular interest for endangered wildlife, as ectoparasites are potential vectors for inter- and intraspecific pathogen transmission and may be indicators to assess the health status of endangered populations. here, ectoparasite dynamics in sympatric populations of two malagasy mouse lemur species, microcebus murinus and m. ravelobensis, were investigated over an 11-month period. furthermore, the animals' body mass was determined as an indicator of body conditio ... | 2018 | 30089527 |
| exogenous lrrk2g2019s induces parkinsonian-like pathology in a nonhuman primate. | parkinson's disease (pd) is the second most prevalent neurodegenerative disease among the elderly. to understand its pathogenesis and to test therapies, animal models that faithfully reproduce key pathological pd hallmarks are needed. as a prelude to developing a model of pd, we tested the tropism, efficacy, biodistribution, and transcriptional effect of canine adenovirus type 2 (cav-2) vectors in the brain of microcebus murinus, a nonhuman primate that naturally develops neurodegenerative lesio ... | 2018 | 30046008 |
| variation in reproduction of the smallest-bodied primate radiation, the mouse lemurs (microcebus spp.): a synopsis. | reproduction is a fundamental trait in the life history of any species and contributes to species diversity and evolution. here, we aim to review the barely known variation in reproductive patterns of the smallest-bodied primate radiation, the malagasy mouse lemurs, focusing on twelve species of four phylogenetic clades. we present a new reproductive field dataset collected between may and november 1996-2016 for nine species (microcebus murinus, m. myoxinus, m. ravelobensis, m. bongolavensis, m. ... | 2018 | 29767414 |
| personality and performance are affected by age and early life parameters in a small primate. | a whole suite of parameters is likely to influence the behavior and performance of individuals as adults, including correlations between phenotypic traits or an individual's developmental context. here, we ask the question whether behavior and physical performance traits are correlated and how early life parameters such as birth weight, litter size, and growth can influence these traits as measured during adulthood. we studied 486 captive gray mouse lemurs (microcebus murinus) and measured two b ... | 2018 | 29760900 |
| a new species of sucking louse (phthiraptera: anoplura: polyplacidae) from the gray mouse lemur, microcebus murinus (primates: cheirogaleidae), in madagascar. | lemurpediculus madagascariensis sp. nov. (phthiraptera: anoplura: polyplacidae) is described from the gray mouse lemur, microcebus murinus (j. f. miller) (primates: cheirogaleidae), from ankarafantsika national park, madagascar. lemurs were trapped using sherman live traps and visually inspected for lice, which were preserved in 90% ethanol. adults of both sexes and the third-instar nymph of the new species are illustrated and distinguished from the four previously known species of lemurpediculu ... | 2018 | 29659934 |
| microcebus murinus: a novel promising non-human primate model of spinal cord injury. | | 2018 | 29623923 |
| treadmill locomotion of the mouse lemur (microcebus murinus); kinematic parameters during symmetrical and asymmetrical gaits. | the gaits of the adult grey mouse lemur microcebus murinus were studied during treadmill locomotion over a large range of velocities. the locomotion sequences were analysed to determine the gait and the various spatiotemporal gait parameters of the limbs. we found that velocity adjustments are accounted for differently by stride frequency and stride length depending on whether the animal showed a symmetrical or an asymmetrical gait. when using symmetrical gaits the increase in velocity is associ ... | 2018 | 29610933 |
| a new look at play fighting. | with this issue, the editors inaugurate the featured article essay in the journalof comparative psychology. this brief essay, written by one or both of the editors, highlights one of the articles in each issue that is found to be particularly important, interesting, or innovative. the editors' choice for this issue is the article by pellis and pellis (2018) about play fighting in gray mouse lemurs (microcebus murinus). (psycinfo database record | 2018 | 29446973 |
| hybrid de novo genome assembly and centromere characterization of the gray mouse lemur (microcebus murinus). | the de novo assembly of repeat-rich mammalian genomes using only high-throughput short read sequencing data typically results in highly fragmented genome assemblies that limit downstream applications. here, we present an iterative approach to hybrid de novo genome assembly that incorporates datasets stemming from multiple genomic technologies and methods. we used this approach to improve the gray mouse lemur (microcebus murinus) genome from early draft status to a near chromosome-scale assembly. | 2017 | 29145861 |
| the sensory thalamus and visual midbrain in mouse lemurs. | mouse lemurs are the smallest of extant primates and are thought to resemble early primates in many ways. we provide histological descriptions of the major sensory nuclei of the dorsal thalamus and the superior colliculus (sc) of mouse lemurs (microcebus murinus). the dorsal lateral geniculate nucleus has the six layers typical of strepsirrhine primates, with matching pairs of magnocellular, parvocellular, and koniocellular layers, one of each pair for each eye. unlike most primates, magnocellul ... | 2019 | 30927368 |
| spontaneous spongiform brainstem degeneration in a young mouse lemur (microcebus murinus) with conspicuous behavioral, motor, growth, and ocular pathologies. | here we report a case of severe growth retardation and neurologic abnormalities in a female gray mouse lemur (microcebus murinus), a small nhp species for which the genomic sequence recently became available. the female lemur we present here died on postnatal day 125. this lemur had impaired development of motor skills and showed severe ataxia and tremors. in addition, hearing seemed normal whereas ophthalmic examination revealed incipient bilateral cataracts, abnormal pigmentation in the lens o ... | 2018 | 30486920 |
| digital templates and brain atlas dataset for the mouse lemur primate. | we present a dataset made of 3d digital brain templates and of an atlas of the gray mouse lemur (microcebus murinus), a small prosimian primate of growing interest for studies of primate biology and evolution. a template image was constructed from in vivo magnetic resonance imaging (mri) data of 34 animals. this template was then manually segmented into 40 cortical, 74 subcortical and 6 cerebro-spinal fluid (csf) regions. additionally, the dataset contains probability maps of gray matter, white ... | 2018 | 30456231 |
| metabolic and genomic adaptations to winter fattening in a primate species, the grey mouse lemur (microcebus murinus). | to understand the mechanisms underlying the development of metabolic changes leading to obesity remains a major world health issue. among such mechanisms, seasonality is quite underestimated although it corresponds to the manifestation of extreme metabolic flexibility in response to a changing environment. nevertheless, the changes induced by such flexibility are far to be understood, especially at the level of insulin signaling, genomic stability or inflammation. | 2018 | 28925409 |
| insect secretions determine habitat use patterns by a female lesser mouse lemur (microcebus murinus). | the lesser mouse lemur (microcebus murinus) is one of six sympatric nocturnal primates found in the kirindy forest, west-madagascar. each of these species is reported to consume a secretion produced during the austral winter by the homopteran insect flatidia coccinea. in july and august 1993 a study was conducted to determine the importance of this food resource in the ecology of female m. murinus. at this study site, animals were distributed only along the forest edge where insect secretions ar ... | 1995 | 31936959 |
| laterality in quadrupedal and bipedal prosimians: reach and whole-body turn in the mouse lemur (microcebus murinus) and the galago (galago moholi). | lateral preferences in food reaching and whole-body turning were assessed in 24 prosimian primates: 16 galagos (galago moholi) and 8 mouse lemurs (microcebus murinus). reach and turn preference in the galago were examined using a single testing procedure; separate procedures were used to evaluate reach and turn preferences in the mouse lemur. the motoric requirements for both species were 1) reach into a plexiglas container with a single hand for a food item and 2) execution of a whole-body rota ... | 1992 | 31948154 |
| sexual dimorphism and sex ratios in madagascan prosimians. | skull length was used to evaluate the extent of sexual dimorphism in size among 21 taxa of extant madagascan prosimians. extraneous sources of variation were controlled by limiting male-female comparisons to museum samples comprised of ten or more wild-caught, adult individuals collected at the same locality (24 samples total). sexual dimorphism in skull length averaged only 1.31%, with equal probability of males or females being larger. the only statistically significant sexual differences were ... | 1991 | 31952395 |