| cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of mirna-27a and mirna-155 in cell survival and inflammation. | several studies have demonstrated that polyphenolics from pomegranate (punica granatum l.) are potent inhibitors of cancer cell proliferation and induce apoptosis, cell cycle arrest, and also decrease inflammation in vitro and vivo. there is growing evidence that botanicals exert their cytotoxic and anti-inflammatory activities, at least in part, by decreasing specificity protein (sp) transcription factors. these are overexpressed in breast tumors and regulate genes important for cancer cell sur ... | 2012 | 22941571 |
| a comprehensive review of punica granatum (pomegranate) properties in toxicological, pharmacological, cellular and molecular biology researches. | punica granatum (pg), commonly known as pomegranate (pg), is a member of the monogeneric family, punicaceae, and is mainly found in iran which is considered to be its primary centre of origin. pg and its chemical components possess various pharmacological and toxicological properties including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiogenesis activities. they also show inhibitory effects on invasion/motility, cell cycle, apoptosis, and v ... | 2012 | 24250463 |
| potential effects of medicinal plants and secondary metabolites on acute lung injury. | acute lung injury (ali) is a life-threatening syndrome that causes high morbidity and mortality worldwide. ali is characterized by increased permeability of the alveolar-capillary membrane, edema, uncontrolled neutrophils migration to the lung, and diffuse alveolar damage, leading to acute hypoxemic respiratory failure. although corticosteroids remain the mainstay of ali treatment, they cause significant side effects. agents of natural origin, such as medicinal plants and their secondary metabol ... | 2013 | 24224172 |