| seroprevalence of viral infections in domestic cats in costa rica. | a cross-sectional survey of a convenient sample of domestic cats from costa rica's greater metropolitan area was carried out to determine the prevalence of antibodies against feline herpesvirus type 1 (fhv-1), feline parvovirus (fpv), feline immunodeficiency virus (fiv) and antigens of feline leukemia virus (felv). blood samples were collected from at least 96 cats from june 1998 to december 2001; data related to the individual cats and household variables were obtained using a questionnaire. an ... | 2009 | 19498296 |
| occurrence, morphological characterization and antigen localization of felid herpesvirus-induced pneumonia in cats: a retrospective study (2000-2006). | the pathological findings in nine cases of pneumonia associated with infection by felid herpesvirus-1 (fehv-1) are presented. the animals affected were five kittens, two subadult cats and two adult cats. the microscopical changes included fibrinonecrotic pneumonia and severe necrosis of the bronchial and bronchiolar epithelium. fehv-1 antigen was detected immunohistochemically in pneumocytes, alveolar macrophages and necrotic bronchial and bronchiolar epithelial cells. in the youngest kitten vir ... | 2009 | 19540511 |
| feline herpesvirus 1 and feline calicivirus infections in a heterogeneous cat population of a rescue shelter. | feline herpesvirus 1 (fehv-1) and feline calicivirus (fcv), associated with upper respiratory tract disease, are highly prevalent in cats worldwide. with the aim to investigate the importance of feline respiratory viruses in a heterogeneous population of cats, samples were taken in a rescue shelter in liège, belgium, between march 2005 and august 2006. reverse transcription polymerase chain reaction (rt-pcr) and polymerase chain reaction (pcr) were performed to diagnose fcv and fehv-1 infection ... | 2009 | 19577497 |
| use of interfering rnas targeted against feline herpesvirus 1 glycoprotein d for inhibition of feline herpesvirus 1 infection of feline kidney cells. | to evaluate the use of rna interference targeted against feline herpesvirus 1 (fhv-1) glycoprotein d for inhibition of fhv-1 infection of feline kidney cells. | 2009 | 19645584 |
| comparison of digital rectal and microchip transponder thermometry in cats. | this study compares the use of traditional rectal thermometry with an implantable microchip temperature transponder in cats. the microchip transponder was implanted over the shoulder blades and was programmed with cat identification information. concurrently, the cats were involved in a study in which they were infected experimentally with feline herpesvirus 1; this situation enabled temperature comparisons in both normal and abnormal ranges. results from the microchip transponder technique were ... | 2009 | 19653950 |
| survival of a cat with pneumonia due to cowpox virus and feline herpesvirus infection. | cowpox virus infection in cats is rare and usually leads to cutaneous lesions alone. pulmonary infection and pneumonia have been documented occasionally but all such cases described to date have been fatal. although usually affecting the upper respiratory tract, feline herpesvirus can also induce pneumonia. the present report describes the case of a cat that recovered from a pneumonia in which both poxvirus and feline herpesvirus were demonstrated. | 2009 | 19769672 |
| effects of dietary lysine supplementation on upper respiratory and ocular disease and detection of infectious organisms in cats within an animal shelter. | to determine within a cat shelter effects of dietary lysine supplementation on nasal and ocular disease and detection of nucleic acids of chlamydophila felis, feline calicivirus (fcv), and feline herpesvirus (fhv-1). | 2009 | 19878022 |
| seroprevalences to viral pathogens in free-ranging and captive cheetahs (acinonyx jubatus) on namibian farmland. | cheetah populations are diminishing rapidly in their natural habitat. one reason for their decline is thought to be a high susceptibility to (infectious) diseases because cheetahs in zoos suffer from high disease-induced mortality. data on the health status of free-ranging cheetahs are scarce, and little is known about their exposure and susceptibility to infectious diseases. we determined seroprevalences to nine key viruses (feline herpesvirus 1, feline calicivirus, feline parvovirus, feline co ... | 2010 | 19955325 |
| age and long-term protective immunity in dogs and cats. | vaccination can provide an immune response that is similar in duration to that following a natural infection. in general, adaptive immunity to viruses develops earliest and is highly effective. such anti-viral immune responses often result in the development of sterile immunity and the duration of immunity (doi) is often lifelong. in contrast, adaptive immunity to bacteria, fungi or parasites develops more slowly and the doi is generally short compared with most systemic viral infections. steril ... | 2010 | 19959181 |
| association of bartonella species, feline calicivirus, and feline herpesvirus 1 infection with gingivostomatitis in cats. | feline gingivostomatitis (fgs) is a common syndrome in cats; feline calicivirus (fcv), feline herpesvirus 1 (fhv-1), and bartonella species are common differential diagnoses. in this study, blood from 70 cats with fgs and 61 healthy control cats was tested for bartonella species antibodies in serum by enzyme-linked immunosorbent assay and western blot immunoassay and dna in blood using a conventional polymerase chain reaction assay. additionally, fresh oral biopsies from cats with fgs (n=42) and ... | 2010 | 19959386 |
| immunohistological evaluation of feline herpesvirus-1 infection in feline eosinophilic dermatoses or stomatitis. | this study used immunohistochemistry (ihc) and histopathology to evaluate the presence of feline herpesvirus-1 (fhv-1) in feline cases of 'eosinophilic granuloma complex' (egc) or other eosinophilic dermatoses or stomatitis, diagnosed at the veterinary pathology diagnostic service, university of sydney between january 1996 and june 2008. two of the 30 cases (6.6%) examined showed positive immunoreactivity to fhv-1 using ihc. intranuclear inclusion bodies were also detected on histopathological e ... | 2010 | 20113951 |
| aetiology of corneal ulcers assume fhv-1 unless proven otherwise. | overview: feline ulcerative keratitis is a common presenting complaint and is frequently a sequela of feline herpesvirus 1 (fhv-1) infection; so much so, in fact, that it is fair to assume an fhv-1 aetiology until proven otherwise. other potential causes of ulceration are trauma or underlying eyelid abnormalities (entropion, ectropion, agenesis, dermoids, neoplasia), lash abnormalities (ectopic cilia, trichiasis), tear film abnormalities or neurological deficiencies (trigeminal nerve paralysis, ... | 2010 | 20123484 |
| antibodies against crandell rees feline kidney (crfk) cell line antigens, alpha-enolase, and annexin a2 in vaccinated and crfk hyperinoculated cats. | cats inoculated with feline herpesvirus 1, calicivirus, and panleukopenia (fvrcp) vaccines grown on the crandell rees feline kidney (crfk) cell line have been shown to develop anti-crfk antibodies. the identities of common crfk antigens are unknown. | 2010 | 20136712 |
| complete genomic sequence and an infectious bac clone of feline herpesvirus-1 (fhv-1). | infection with feline herpesvirus-1 (fhv-1) is a major cause of upper respiratory and ocular diseases in felidae. we report the first complete genomic sequence of fhv-1, as well as the construction and characterization of a bacterial artificial chromosome (bac) clone of fhv-1, which contains the entire fhv-1 genome and has the bac vector inserted at the left end of u(l). complete genomic sequences were derived from both the fhv-1 bac clone and purified virion dna. the fhv-1 genome is 135,797bp i ... | 2010 | 20304455 |
| treatment of corneal ulcers: what are the medical options? | practical relevance: corneal ulcers in cats (ulcerative keratitis) are a common presenting complaint, and are a frequent sequela to feline herpesvirus (fhv-1) infection. in fact, it is fair to assume an fhv-1 aetiology until proven otherwise. in practice, therefore, many cases of corneal ulceration can be treated medically, but treatment can frequently be challenging, with the need to tailor therapy carefully to the type of ulcer, the individual cat and its temperament. patient group: all age gr ... | 2010 | 20417899 |
| treatment of corneal ulcers: when is surgery indicated? | practical relevance: while corneal ulcers in cats frequently arise secondarily to feline herpesvirus (fhv-1) infection, and thus medical therapy is often indicated, other causes include trauma, eyelid abnormalities (agenesis, entropion, dermoids and neoplasia), tear film abnormalities and neurological deficiencies (trigeminal nerve paralysis or facial nerve paralysis). in some such cases, surgery is required. treatment always needs to be tailored carefully according to the depth and progression ... | 2010 | 20417900 |
| evaluation of the effects of small interfering rnas on in vitro replication of feline herpesvirus-1. | to evaluate the ability of 5 small interfering rnas (sirnas) targeting mrna of the feline herpesvirus-1 (fhv-1) dna polymerase gene to reduce in vitro viral replication and gene expression of fhv-1, to evaluate combinations of these sirnas with sirnas that target the glycoprotein d gene of fhv-1, and to determine the combination or combinations of sirnas that yield the greatest inhibition of in vitro viral replication. | 2010 | 20513181 |
| stability of 0.5% cidofovir stored under various conditions for up to 6 months. | to evaluate the effect of time, temperature and storage vial material on the antiviral activity of 0.5% cidofovir solution. | 2010 | 20618808 |
| feline herpesvirus 1 and chlamydophila felis prevalence in cats with chronic conjunctivitis. | the prevalence of chlamydophila felis and feline herpesvirus type 1 was investigated in 30 cats with chronic conjunctivitis, with use of conjunctival swabs and conventional polymerase chain reaction (pcr). in cats with chronic conjunctivitis the dna of c. felis and fhv-1 was detected in 2 of 30 cats (6.7%) and in 10 of 30 animals (33.3%), respectively. one case of fhv-1 dna, and none of c. felis was found in control group. there was no case of co-infection with both pathogens. | 2010 | 20731196 |
| comparison of polymerase chain reaction tests for diagnosis of feline herpesvirus, chlamydophila felis, and mycoplasma spp. infection in cats with ocular disease in canada. | this study assessed the value of polymerase chain reaction (pcr) for making a diagnosis of feline herpesvirus (fhv-1) infection, and for differentiating this from chlamydophila felis and mycoplasma spp. infection in a clinical setting in canada. we compared the frequency of positive fhv-1 pcr test results from 48 clinical cases of ocular disease in cats suspected to be due to fhv-1 between 1 research and 2 commercial laboratories in canada. we also compared pcr results for chlamydophila felis an ... | 2010 | 20808575 |
| detection of bacterial and viral organisms from the conjunctiva of cats with conjunctivitis and upper respiratory tract disease. | a variety of pathogens are involved in conjunctivitis in cats. in this study, the prevalence of feline herpesvirus (fhv), chlamydophila felis, mycoplasmas, and aerobic bacteria on the conjunctival surface of cats with conjunctivitis and upper respiratory tract disease was investigated by polymerase chain reaction (pcr), immunofluorescent assay (ifa), and aerobic bacterial culture of ocular swabs. forty-one cats were included of which 37 were found to be infected with an ocular organism. single a ... | 2010 | 20817584 |
| bartonella species, feline herpesvirus-1, and toxoplasma gondii pcr assay results from blood and aqueous humor samples from 104 cats with naturally occurring endogenous uveitis. | toxoplasma gondii, bartonella henselae and feline herpesvirus-1 (fhv-1) have been implicated as causative agents in feline uveitis. the usefulness of serum and aqueous humor (ah) antibody testing for these agents is limited as antibodies can be detected in both healthy cats and cats with uveitis. very few studies using polymerase chain reaction (pcr) assays to amplify organism dna from samples from cats with uveitis have been performed. in this study, assays to detect t gondii antibodies, feline ... | 2010 | 20817587 |
| prevalence of select infectious agents in inflammatory aural and nasopharyngeal polyps from client-owned cats. | benign, inflammatory polyps may affect the nasopharynx and auditory canal of cats. it has been proposed that inflammation induced by infectious disease agents could trigger polyp formation. the objective of this pilot study was to determine the prevalence of feline herpesvirus-1 (fhv-1), feline calicivirus (fcv), mycoplasma species, bartonella species and chlamydophila felis nucleic acids in polyp tissues collected from 30 clinically affected cats. samples collected from the tympanic bulla from ... | 2010 | 20850367 |
| infectious causes for feline upper respiratory tract disease--a case-control study. | the aim of this case-control study was to investigate the prevalence of microorganisms in group-living cats with clinical signs of upper respiratory tract disease (urtd), in in-contact cats and in cats in groups without urtd problems. samples were taken from the ventral conjunctival fornix for analysis of feline herpesvirus-1 (fhv), mycoplasma felis and chlamydiaceae using a real-time polymerase chain reaction technique. the oropharynx was sampled for bacteriological culture and viral isolation. ... | 2010 | 20851008 |
| antiviral therapy for feline herpesvirus infections. | a large variety of antiviral agents exists for oral or topical treatment of cats infected with feline herpesvirus type 1. knowledge of the general principles can be used to better understand antiviral pharmacology and thereby guide therapy for cats with herpetic disease. this article compares the antiviral efficacy of these compounds and recommends a common protocol for administering lysine and antiviral drugs to infected cats. | 2010 | 20933135 |
| relevance of feline calicivirus, feline immunodeficiency virus, feline leukemia virus, feline herpesvirus and bartonella henselae in cats with chronic gingivostomatitis. | despite its common occurrence, the aetiology of chronic gingivostomatitis in cats remains uncertain. aetiology is likely multifactorial, and several infectious agents may be associated with chronic gingivostomatitis. the purpose of this study was to investigate the prevalence of feline calicivirus (fcv), feline immunodeficiency virus (fiv), feline leukemia virus (felv), feline herpesvirus (fhv), and bartonella henselae (b. henselae) in cats with chronic gingivostomatitis and in an age-matched co ... | 2010 | 21038808 |
| the capacity of ul49.5 proteins to inhibit tap is widely distributed among members of the genus varicellovirus. | the lifelong infection by varicelloviruses is characterized by a fine balance between the host immune response and immune evasion strategies used by these viruses. virus-derived peptides are presented to cytotoxic t lymphocytes by major histocompatibility complex (mhc) class i molecules. the transporter associated with antigen processing (tap) transports the peptides from the cytosol into the endoplasmic reticulum, where the loading of mhc-i molecules occurs. the varicelloviruses bovine herpesvi ... | 2010 | 21159875 |
| evaluation of orally administered famciclovir in cats experimentally infected with feline herpesvirus type-1. | to evaluate orally administered famciclovir for treatment of cats with experimentally induced disease attributable to feline herpesvirus type-1 (fhv-1). | 2011 | 21194340 |
| results of molecular diagnostic assays targeting feline herpesvirus-1 and feline calicivirus in adult cats administered modified live vaccines. | in this pilot study, 12 adult, gang-housed cats that were known to be previously exposed (n=12) to feline herpesvirus-1 (fhv-1) and/or vaccinated against (n=2) feline calicivirus (fcv) and fhv-1 were randomly assigned to one of two groups of six cats each. nasal and pharyngeal samples were collected from each cat on days -7, -3, and 0 prior to vaccination and on days 3, 7, 10, 14, 17, 21, and 28 after vaccination with an fhv-1, fcv, and panleukopenia (fvrcp) vaccine developed for intranasal (six ... | 2011 | 21439879 |
| feline herpesvirus-1 ocular manifestations, diagnosis and treatment options. | practical relevance: feline herpesvirus-1 (fhv-1) is a major cause of feline morbidity. following exposure to the virus, virtually all cats become persistently infected and many of these will develop recrudescent disease on one or more occasions during their lifetime. acute ocular herpetic disease manifests as conjunctivitis, corneal ulceration and keratitis, and can be severe and painful. repeated bouts of recrudescent ocular disease can lead to progressive corneal pathology that can be ultimat ... | 2011 | 21515221 |
| histologic and molecular correlation in shelter cats with acute upper respiratory infection. | this is a descriptive study designed to correlate diagnostic real-time pcr results with histopathologic lesions in cats with clinical signs of upper respiratory infection (uri). the study occurred over a 9-month period in a single open-intake animal shelter. cats that were selected for euthanasia by the shelter staff and additionally had uri were included in the study for a total of 22 study cats. combined conjunctival and oropharyngeal swabs were tested by quantitative real-time polymerase chai ... | 2011 | 21562109 |
| structural and functional analysis of the tap-inhibiting ul49.5 proteins of varicelloviruses. | viral infections are counteracted by virus-specific cytotoxic t cells that recognize the infected cell via mhc class i (mhc i) molecules presenting virus-derived peptides. the loading of the peptides onto mhc i molecules occurs in the endoplasmic reticulum (er) and is facilitated by the peptide loading complex. a key player in this complex is the transporter associated with antigen processing (tap), which translocates the viral peptides from the cytosol into the er. herpesviruses have developed ... | 2011 | 21764135 |
| inbreeding depression increases susceptibility to bovine tuberculosis in lions: an experimental test using an inbred-outbred contrast through translocation. | disease can dramatically influence the dynamics of endangered wildlife populations, especially when they are small and isolated, with increased risk of inbreeding. in hluhluwe-imfolozi park (hip), a small, enclosed reserve in south africa, a large lion (panthera leo) population arose from a small founder group in the 1960s and started showing conspicuous signs of inbreeding. to restore the health status of the hip lion population, outbred lions were translocated into the existing population. in ... | 2011 | 21719814 |
| Surveillance using serological and molecular methods for the detection of infectious agents in captive Brazilian neotropic and exotic felids. | The aim of the current study was to investigate the exposure of captive wild felids to various infectious pathogens using serological and molecular methods. One hundred and fifty-nine neotropic felids and 51 exotic felids from 28 captive settings in Brazil were tested. While antibodies against Feline parvovirus and Feline coronavirus (FCoV), Feline calicivirus and Bartonella spp. were frequently detected by serologic tests, antibodies against Felid herpesvirus 1 or infection with hemotropic myco ... | 2011 | 21908268 |
| the in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time pcr assays used for the diagnosis of feline herpesvirus 1 and chlamydophila felis infections. | to investigate the possible inhibition of qpcr assays used for the diagnosis of ocular infections in cats by proxymetacaine, fluorescein, and fusidic acid, which are commonly used in veterinary ophthalmology. | 2011 | 21923818 |
| detection of protective antibody titers against feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus in shelter cats using a point-of-care elisa. | serum antibody titers are a useful measurement of protection against infection (feline panleukopenia virus [fpv]) or clinical disease (feline herpesvirus-1 [fhv] and feline calicivirus [fcv]), and their determination has been recommended as part of disease outbreak management in animal shelters. the objective of this study was to determine the sensitivity, specificity, and inter-observer and inter-assay agreement of two semi-quantitative point-of-care assays for the detection of protective antib ... | 2011 | 21885311 |
| the antiviral activity of six south african plants traditionally used against infections in ethnoveterinary medicine. | viral infections remain a major threat to humans and animals and there is a crucial need for new antiviral agents especially with the development of resistant viruses. the hexane, dichloromethane, acetone and methanol extracts of six plant species selected for their traditional use against infections were tested for in vitro antiviral activity against canine distemper virus (cdv), canine parainfluenza virus-2 (cpiv-2), feline herpesvirus-1 (fhv-1) and lumpy skin disease virus (lsdv). all extract ... | 2011 | 21982126 |
| true versus false parasite interactions: a robust method to take risk factors into account and its application to feline viruses. | multiple infections are common in natural host populations and interspecific parasite interactions are therefore likely within a host individual. as they may seriously impact the circulation of certain parasites and the emergence and management of infectious diseases, their study is essential. in the field, detecting parasite interactions is rendered difficult by the fact that a large number of co-infected individuals may also be observed when two parasites share common risk factors. to correct ... | 2012 | 22235312 |
| companion animal disease surveillance: a new solution to an old problem? | infectious disease surveillance in companion animals has a long history. however, it has mostly taken the form of ad hoc surveys, or has focused on adverse reactions to pharmaceuticals. in 2006 a blue ribbon panel was convened by the u.s. white house office of science and technology policy to discuss the potential utility of a national companion animal health surveillance system. such a system could provide fundamental information about disease occurrence, transmission and risk factors; and coul ... | 2011 | 22748174 |
| pneumomediastinum and subcutaneous emphysema in a cat associated with necrotizing bronchopneumonia caused by feline herpesvirus-1. | this report describes a 1-year-old cat with acute dyspnea. thoracic radiography revealed a pneumomediastinum and severe subcutaneous emphysema. lower airway surgical exploration was unable to determine the cause. at postmortem examination, acute necrotizing bronchopneumonia and fibrinonecrotic tracheitis due to feline herpesvirus-1 were diagnosed. | 2011 | 22467969 |
| cutaneous viral dermatoses in dogs and cats. | cutaneous viral dermatoses are often underdiagnosed in dogs and cats because they are rare, and because it is difficult to identify an exact causative agent. even so, practitioners in primary care may encounter some characteristic clinical features. this article reviews commonly encountered dermatoses, particularly papillomavirus-associated dermatoses in dogs and cats. it also provides a brief overview of several other dermatoses associated with feline herpesvirus, feline calicivirus, felv, and ... | 2012 | 23677843 |
| descriptive epidemiology of upper respiratory disease and associated risk factors in cats in an animal shelter in coastal western canada. | we examined 250 cats at an animal shelter in the coastal temperate region of canada to determine whether age, source, gender, and sterilization status influenced risk of shedding at intake, transmission of infection, and development of clinical upper respiratory disease (urd). on admission, 28% of the cats were positive for 1 or more infectious agent related to urd; 21% were carriers of mycoplasma felis and < 3% were carriers of feline calicivirus (fcv), feline herpesvirus-1 (fhv-1) or bordetell ... | 2013 | 23904635 |
| feline calicivirus and other respiratory pathogens in cats with feline calicivirus-related symptoms and in clinically healthy cats in switzerland. | cats with feline calicivirus (fcv)-related symptoms are commonly presented to veterinary practitioners. various clinical manifestations have been attributed to fcv, i.e. upper respiratory tract disease (urtd), oral ulcerations, gingivostomatitis, limping syndrome and virulent systemic disease. additionally, healthy cats can shed fcv. the aims of this study were 1) to investigate the frequency of fcv in cats with fcv-related symptoms and in healthy cats in switzerland, 2) to assess risk and prote ... | 2015 | 26566897 |
| surveillance for viral and parasitic pathogens in a vulnerable african lion (panthera leo) population in the northern tuli game reserve, botswana. | african lion ( panthera leo ) numbers are decreasing rapidly and populations are becoming smaller and more fragmented. infectious diseases are one of numerous issues threatening free-ranging lion populations, and low-density populations are particularly at risk. we collected data on the prevalence and diversity of viral and parasitic pathogens in a small lion population in eastern botswana. during 2012 and 2014, blood samples were collected from 59% (n=13) of the adult-subadult lions in the nort ... | 2017 | 27669009 |
| detection of feline upper respiratory tract disease pathogens using a commercially available real-time pcr test. | feline herpesvirus (fhv-1), feline calicivirus (fcv), bordetella bronchiseptica (bb), chlamydia felis (cf) and mycoplasma felis (mf) are common infectious agents identified in cats with upper respiratory tract disease (urtd). each of these agents can either act as primary pathogens or cause subclinical infections, and pathogen identification can be used to prevent disease transmission in shelters, or to manage individual cats with recurrent urtd. the aim of this study was to compare pathogen det ... | 2015 | 26324635 |
| pulmonary cowpox in cats: five cases. | this case series documents five cases of pneumonia (with pleural effusion in three cases) caused by cowpox virus (cpxv) in domestic cats. predisposition to pneumonia may have resulted from mixed infections in two cases (feline herpesvirus and bordetella bronchiseptica in one cat, and mycoplasma species in the other). | 2016 | 25972246 |
| effect of gentle stroking and vocalization on behaviour, mucosal immunity and upper respiratory disease in anxious shelter cats. | emotional, behavioural, and health benefits of gentle stroking and vocalizations, otherwise known as gentling, have been documented for several species, but little is known about the effect of gentling on cats in stressful situations. in this study, 139 cats rated as anxious upon admission to an animal shelter were allocated to either a gentled or control group. cats were gentled four times daily for 10 min over a period of 10 days, with the aid of a tool for cats that were too aggressive to han ... | 2014 | 25064364 |
| pediatric feline upper respiratory disease. | infectious feline upper respiratory tract disease (urtd) continues to be a widespread and important cause of morbidity and mortality in kittens. multiple pathogens can contribute to urtd in kittens, and coinfections are common in overcrowded environments and contribute to increased disease severity. worldwide, the most prevalent pathogens are feline herpesvirus-1 and feline calicivirus. primary bacterial causes of urtd in cats include bordetella bronchiseptica, chlamydia felis, and mycoplasma sp ... | 2014 | 24580994 |
| efficacy of intranasal administration of a modified live feline herpesvirus 1 and feline calicivirus vaccine against disease caused by bordetella bronchiseptica after experimental challenge. | studies suggest that intranasal vaccination can stimulate nonspecific immunity against agents not contained within the vaccine, but this effect is not reported for cats. | 2016 | 22860699 |
| recombinase polymerase amplification assay-a simple, fast and cost-effective alternative to real time pcr for specific detection of feline herpesvirus-1. | feline herpesvirus 1 (fhv-1), an enveloped dsdna virus, is one of the major pathogens of feline upper respiratory tract disease (urtd) and ocular disease. currently, polymerase chain reaction (pcr) remains the gold standard diagnostic tool for fhv-1 infection but is relatively expensive, requires well-equipped laboratories and is not suitable for field tests. recombinase polymerase amplification (rpa), an isothermal gene amplification technology, has been explored for the molecular diagnosis of ... | 2017 | 28045956 |
| epidemiologically non-feasible singleton reactors at the final stage of bohv1 eradication: serological evidence of bohv2 cross-reactivity. | a voluntary marker-independent bovine herpesvirus 1 (bohv1) eradication program started in 1986; in 1998 it changed to a compulsory one. certification of free regions in european member states is based on article 10 of directive 64/432/eec. according to this rule bavaria is listed as free of bohv1 since october 2011. surveillance of bohv1-free dairy cattle farms is currently performed with quarterly bulk-milk testing. non-negative bulk-milk results must be confirmed by blood tests in cattle olde ... | 2012 | 22578637 |
| exposure to selected pathogens in to selected pathogens in geoffroy's cats and domestic carnivores from central argentina. | wild carnivores share a high percentage of parasites and viruses with closely related domestic carnivores. because of increased overlap and potential contact with domestic species, we conducted a retrospective serosurvey for 11 common carnivore pathogens in 40 geoffroy's cats (leopardus geoffroyi) sampled between 2000 and 2008 within or near two protected areas in central argentina (lihué calel national park, la pampa, and campos del tuyú national park, buenos aires), as well as five domestic ca ... | 2012 | 23060491 |
| antiviral activity of a bacillus sp. p34 peptide against pathogenic viruses of domestic animals. | p34 is an antimicrobial peptide produced by a bacillus sp. strain isolated from the intestinal contents of a fish in the brazilian amazon basin with reported antibacterial activity. the aim of this work was to evaluate the peptide p34 for its in vitro antiviral properties against canine adenovirus type 2 (cav-2), canine coronavirus (ccov), canine distemper virus (cdv), canine parvovirus type 2 (cpv-2), equine arteritis virus (eav), equine influenza virus (eiv), feline calicivirus (fcv) and felin ... | 2014 | 25477947 |
| serosurvey for selected viral pathogens among sympatric species of the african large predator guild in northern botswana. | the recent increase in the creation of transboundary protected areas and wildlife corridors between them lends importance to information on pathogen prevalence and transmission among wildlife species that will become connected. one such initiative is the kavango zambezi transfrontier conservation area of which botswana's okavango delta constitutes a major contribution for wildlife and ecosystems. between 2008 and 2011, we collected serum samples from 14 lions ( panthera leo ), four leopards ( pa ... | 2017 | 27763827 |
| common and emerging infectious diseases in the animal shelter. | the beneficial role that animal shelters play is unquestionable. an estimated 3 to 4 million animals are cared for or placed in homes each year, and most shelters promote public health and support responsible pet ownership. it is, nonetheless, inevitable that shelters are prime examples of anthropogenic biological instability: even well-run shelters often house transient, displaced, and mixed populations of animals. many of these animals have received minimal to no prior health care, and some ha ... | 2014 | 24265288 |
| risk factors for exposure to feline pathogens in california mountain lions (puma concolor). | the primary challenge to mountain lion population viability in california is habitat loss and fragmentation. these habitat impacts could enhance disease risk by increasing contact with domestic animals and by altering patterns of exposure to other wild felids. we performed a serologic survey for feline pathogens in california mountain lions (puma concolor) using 490 samples from 45 counties collected from 1990 to 2008. most mountain lions sampled were killed because of depredation or public safe ... | 2013 | 23568903 |
| occurrence of chlamydophila felis, feline herpesvirus 1 and calcivirus in domestic cats of iran. | feline herpesvirus-1, feline calicivirus and chlamydophila felis are the main causes of feline upper respiratory tract disease. this study was conducted to identify of fehv-1, fcv and c. felis infections in domestic cat population and also to estimate the prevalence of each specific infection in iran. | 2016 | 28149490 |
| prevalence of feline herpesvirus-1, feline calicivirus, chlamydophila felis and mycoplasma felis dna and associated risk factors in cats in spain with upper respiratory tract disease, conjunctivitis and/or gingivostomatitis. | objectives our objective was to perform the first multicentric study in spain to evaluate the prevalence of feline herpesvirus-1 (fhv-1), feline calicivirus (fcv), chlamydophila felis and mycoplasma felis in cats with upper respiratory tract disease (urtd), conjunctivitis and/or gingivostomatitis (gs) compared with control cats; and to evaluate risk factors for these clinical conditions. methods conjunctival and oropharyngeal swabs were collected and a questionnaire regarding signalment, lifesty ... | 2017 | 26919892 |
| rapid and sensitive detection of feline immunodeficiency virus using an insulated isothermal pcr-based assay with a point-of-need pcr detection platform. | feline immunodeficiency virus (fiv) is an important infectious agent of cats. clinical syndromes resulting from fiv infection include immunodeficiency, opportunistic infections, and neoplasia. in our study, a 5' long terminal repeat/gag region-based reverse transcription insulated isothermal polymerase chain reaction (rt-iipcr) was developed to amplify all known fiv strains to facilitate point-of-need fiv diagnosis. the rt-iipcr method was applied in a point-of-need pcr detection platform--a fie ... | 2015 | 26185125 |
| sampling sites for detection of feline herpesvirus-1, feline calicivirus and chlamydia felis in cats with feline upper respiratory tract disease. | feline herpesvirus-1 (fhv-1), feline calicivirus (fcv) and chlamydia felis are involved in feline upper respiratory tract disease (furtd). clinical signs caused by these agents can overlap, and the involvement of certain pathogens is often unpredictable. the objectives of this study were to compare detection rates of fhv-1, fcv and c felis at different sampling sites, and to investigate the correlation between positive test results and clinical signs in cats with furtd. | 2015 | 25660223 |
| evaluation of cytologic findings in feline conjunctivitis. | cytologic examination of smears prepared from ocular swabs of conjunctiva from cats with conjunctivitis permits identification of the type of inflammation and possibly specific microorganisms. results of studies of the diagnostic utility of cytology for detection of infectious causes of feline conjunctivitis have been inconsistent. | 2012 | 22551068 |
| coinfection with clostridium piliforme and felid herpesvirus 1 in a kitten. | a 1-month-old domestic shorthair kitten was submitted for autopsy, with a history of upper respiratory tract infection and diarrhea. this was the third kitten from the same litter that had died with similar clinical findings within a period of 1 month. severe conjunctivitis, rhinitis, tracheitis, and bronchointerstitial pneumonia were present, together with lymphohistiocytic colitis. respiratory lesions were caused by infection with felid herpesvirus 1. colonic lesions were associated with the p ... | 2015 | 26179103 |
| polyprenyl immunostimulant in feline rhinotracheitis: randomized placebo-controlled experimental and field safety studies. | feline rhinotracheitis is a ubiquitous disease caused by feline herpesvirus type 1 (fhv-1). the disease is easily transmissible and common in multi-cat environments where even vaccinated cats can develop clinical signs of respiratory or ocular disease or both when exposed to the virus. prior to the work reported here, there was no licensed treatment for the disease on the market. we hypothesized that polyprenyl immunostimulant (pi), an immunomodulatory veterinary biologic, would be useful in tre ... | 2017 | 28289684 |
| identification of inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses. | inonotus obliquus polysaccharides (iops) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, aids, pancreatitis and other diseases. in this study, we found that iop can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. using cell models of feline calicivirus (fcv), we demonstrated that iop treatment was capable of exhibiting anti-fcv strain f9 activity in cell-based assays and also showed low cytotoxicity. investigation ... | 2017 | 27865960 |
| clinical improvement in feline herpesvirus 1 infected cats by oral low dose of interleukin-12 plus interferon-gamma. | feline herpesvirus 1 (fhv-1) is a widespread cat pathogen inducing rhinitis, conjunctivitis and corneal ulcers. to alleviate acute fhv-1-induced disease, antiviral agents are used often with antibiotics. but sometimes, these treatments, as well as conventional doses of cytokines have moderate efficacy and/or collateral effects. herein we have investigated the effects of low dose interleukin (il)-12 plus interferon (ifn)-gamma, prepared by sequential kinetic activated (ska), on the treatment of f ... | 2016 | 27638118 |
| low genetic diversity among historical and contemporary clinical isolates of felid herpesvirus 1. | felid herpesvirus 1 (fhv-1) causes upper respiratory tract diseases in cats worldwide, including nasal and ocular discharge, conjunctivitis and oral ulceration. the nature and severity of disease can vary between clinical cases. genetic determinants of virulence are likely to contribute to differences in the in vivo phenotype of fhv-1 isolates, but to date there have been limited studies investigating fhv-1 genetic diversity. this study used next generation sequencing to compare the genomes of c ... | 2016 | 27589862 |
| oral administration of famciclovir for treatment of spontaneous ocular, respiratory, or dermatologic disease attributed to feline herpesvirus type 1: 59 cases (2006-2013). | objective to evaluate outcomes for cats treated with orally administered famciclovir 3 times/d for clinical signs attributed to naturally occurring feline herpesvirus type 1 (fhv-1) infection and to assess variables related to owner satisfaction with the treatment. design retrospective case series. animals 59 client-owned cats. procedures medical records were reviewed to identify cats treated for presumed fhv-1 infection from 2006 through 2013 with ≥ 1 follow-up visit. signalment, duration of cl ... | 2016 | 27556267 |
| pharmacokinetic modeling of penciclovir and brl42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. | objectives to determine, following oral administration of famciclovir, pharmacokinetic (pk) parameters for 2 of its metabolites (penciclovir and brl42359) in plasma and tears of healthy cats so that famciclovir dosage recommendations for the treatment of herpetic disease can be optimized. animals 7 male domestic shorthair cats. procedures in a crossover study, each of 3 doses of famciclovir (30, 40, or 90 mg/kg) was administered every 8 or 12 hours for 3 days. six cats were randomly assigned to ... | 2016 | 27463546 |
| effect of modified live or inactivated feline herpesvirus-1 parenteral vaccines on clinical and laboratory findings following viral challenge. | the objective was to investigate the effect of one dose of an inactivated feline herpesvirus-1 (fhv-1), feline calicivirus (fcv) and panleukopenia virus (fpv) vaccine (fvrcp) or one dose of a modified live (ml) fvrcp vaccine on clinical signs and shedding of fhv-1 in specific pathogen-free kittens after challenge with fhv-1 7 days after vaccination. | 2016 | 27432436 |
| feline epitheliotropic mastocytic conjunctivitis in 15 cats. | mast cell infiltration occurs in malignant, inflammatory (eg, allergic, infectious), and idiopathic disease processes in humans and animals. here, we describe the clinical and histological features of a unique proliferative conjunctivitis occurring in 15 cats. ocular specimens were examined histologically, and polymerase chain reaction (pcr) for feline herpesvirus 1 (fhv-1) was performed on ocular tissues obtained from 10 cats. cats had a median age of 8 years (range: 7 months-17.5 years). the k ... | 2017 | 27371540 |
| pathogen exposure varies widely among sympatric populations of wild and domestic felids across the united states. | understanding how landscape, host, and pathogen traits contribute to disease exposure requires systematic evaluations of pathogens within and among host species and geographic regions. the relative importance of these attributes is critical for management of wildlife and mitigating domestic animal and human disease, particularly given rapid ecological changes, such as urbanization. we screened > 1000 samples from sympatric populations of puma (puma concolor), bobcat (lynx rufus), and domestic ca ... | 2016 | 27209780 |
| in vitro characterization of felid herpesvirus 1 (fhv-1) mutants generated by recombineering in a recombinant bac vector. | felid herpesvirus 1 (fhv-1) mutants were constructed using two-step red-mediated recombination techniques based on a virulent full-length fhv-1 bac clone. the individual mutant viruses generated were deficient in glycoprotein c (gc), glycoprotein e (ge), us3 serine/threonine protein kinase (pk), or both ge and thymidine kinase (tk). the gc- mutant virus produced plaques that were similar in size to those resulting from infection with the c-27 parent strain. in contrast, the ge(-), pk(-), and ge( ... | 2016 | 27157860 |
| a review of antiviral drugs and other compounds with activity against feline herpesvirus type 1. | feline herpesvirus type 1 (fhv-1) is a common and important cause of ocular surface disease, dermatitis, respiratory disease, and potentially intraocular disease in cats. many antiviral drugs developed for the treatment of humans infected with herpesviruses have been used to treat cats infected with fhv-1. translational use of drugs in this manner ideally requires methodical investigation of their in vitro efficacy against fhv-1 followed by pharmacokinetic and safety trials in normal cats. subse ... | 2016 | 27091747 |
| a novel corneal explant model system to evaluate antiviral drugs against feline herpesvirus type 1 (fhv-1). | feline herpesvirus type-1 (fhv-1) is the most common viral cause of ocular surface disease in cats. many antiviral drugs are used to treat fhv-1, but require frequent topical application and most lack well-controlled in vivo studies to justify their clinical use. therefore, better validation of current and novel treatment options are urgently needed. here, we report on the development of a feline whole corneal explant model that supports fhv-1 replication and thus can be used as a novel model sy ... | 2016 | 26959283 |
| pneumonia and gastritis in a cat caused by feline herpesvirus-1. | we report a case of fatal respiratory and gastric herpesvirus infection in a vaccinated, adult cat with no known immunosuppression or debilitation. the disease was characterized by severe necrotizing bronchopneumonia, fibrinonecrotic laryngotracheitis, and multifocal necrotizing gastritis associated with eosinophilic intranuclear inclusion bodies and a large amount of feline herpesvirus-1 antigen detected with immunohistochemistry. | 2016 | 26834264 |
| use of a feline respiratory epithelial cell culture system grown at the air-liquid interface to characterize the innate immune response following feline herpesvirus 1 infection. | infection with feline herpesvirus-1 (fhv-1) accounts for 50% of viral upper respiratory diseases in domestic cats and is a significant cause of ocular diseases. despite the clinical significance and high prevalence of fhv-1 infection, currently available vaccines cannot completely protect cats from infection and lifelong latency. fhv-1 infects via the mucous membranes and replicates in respiratory epithelial cells, but very little is known about the early innate immunity at this site. to address ... | 2016 | 26795546 |
| molecular characterization and virus neutralization patterns of severe, non-epizootic forms of feline calicivirus infections resembling virulent systemic disease in cats in switzerland and in liechtenstein. | feline calicivirus (fcv) infections are associated with oral ulceration, chronic stomatitis and a limping syndrome. epizootic outbreaks of virulent systemic disease (vsd) have been reported in the usa and europe. here, the molecular characterization and neutralization patterns of fcv isolates from cases of severe, non-epizootic infection associated with skin ulceration and edema are presented. samples from eleven symptomatic cats, four in-contact cats and 27 cats with no contact with symptomatic ... | 2016 | 26711049 |
| lysine supplementation is not effective for the prevention or treatment of feline herpesvirus 1 infection in cats: a systematic review. | feline herpesvirus 1 is a highly contagious virus that affects many cats. virus infection presents with flu-like signs and irritation of ocular and nasal regions. while cats can recover from active infections without medical treatment, examination by a veterinarian is recommended. lysine supplementation appears to be a popular intervention (recommended by > 90 % of veterinarians in cat hospitals). we investigated the scientific merit of lysine supplementation by systematically reviewing all rele ... | 2015 | 26573523 |
| treatment of chronic herpesviral dermatitis in a captive cheetah (acinonyx jubatus) in namibia. | a 9-yr-old male cheetah (acinonyx jubatus) housed at the cheetah conservation fund in namibia developed cutaneous lesions consisting of alopecia, erythema, ulceration, and crusting on the left fore and hind limbs. histopathology of skin biopsies in conjunction with indirect fluorescent antibody and polymerase chain reaction testing confirmed a diagnosis of feline herpesvirus-1 dermatitis; microbial culture indicated secondary bacterial infection. therapy included targeted systemic antimicrobial ... | 2015 | 26352979 |
| ex vivo modeling of feline herpesvirus replication in ocular and respiratory mucosae, the primary targets of infection. | feline herpesvirus 1 (fehv-1) is a major cause of rhinotracheitis and ocular diseases in cats. in the present study, the viral replication at the primary infection sites was studied using feline respiratory and ocular mucosa explants. the explants of three cats were maintained in an air-liquid culture up to 96 hours without loss of viability. after inoculation with fehv-1 (c27), no evidence of infection was noted in corneal epithelium, while plaque-wise replication was observed in conjunctival a ... | 2015 | 26277778 |
| evaluation of intranasal vaccine administration and high-dose interferon- α2b therapy for treatment of chronic upper respiratory tract infections in shelter cats. | clinical signs of upper respiratory tract infection can be hard to manage in cats, particularly those in shelters. in this study, clinical data were collected from chronically ill (3-4 weeks' duration) cats with suspected feline herpesvirus-1 (fhv-1) or feline calicivirus (fcv) infections after administration of one of two novel therapies. group a cats were administered a commercially available formulation of human interferon-α2b at 10,000 u/kg subcutaneously for 14 days, and group b cats were a ... | 2016 | 26269455 |
| identification of the peptide derived from s1 domain that inhibits type i and type ii feline infectious peritonitis virus infection. | feline infectious peritonitis virus (fipv) can cause a lethal disease in cats, feline infectious peritonitis (fip). a therapeutic drug that is effective against fip has not yet been developed. peptides based on viral protein amino acid sequences have recently been attracting attention as new antiviral drugs. in the present study, we synthesized 30 overlapping peptides based on the amino acid sequence of the s1 domain of the type i fipv strain ku-2 s protein, and investigated their inhibitory eff ... | 2015 | 25896976 |
| herpesvirus and calicivirus infection in a black-footed cat (fels nigripes) family group following vaccination. | preventive healthcare recommendations for zoo felids include vaccination against primary viral diseases that affect domestic felids. although associated with a more-substantial immune response in their domestic counterparts, use of modified live virus vaccines (mlv) in nondomestic carnivores can result in vaccine-induced viral disease. this case report details a feline herpesvirus and calicivirus outbreak in two black-footed cat (felis nigripes) kittens and their dam following use of an mlv in t ... | 2015 | 25831588 |
| three-year duration of immunity for feline herpesvirus and calicivirus evaluated in a controlled vaccination-challenge laboratory trial. | feline vaccination guidelines recommend less frequent boosters for the core vaccines (rhinotracheitis, calicivirosis and infectious panleucopenia). most guidelines recommend boosters at 3-yearly intervals after a basic vaccination including primary vaccination and revaccination one year later. the objective of this study was to assess the duration of immunity induced by purevax(®) rcpch felv, a non-adjuvanted vaccine against feline rhinotracheitis, calicivirosis, infectious panleucopenia, chlamy ... | 2015 | 25824128 |
| molecular and clinical study on prevalence of feline herpesvirus type 1 and calicivirus in correlation with feline leukemia and immunodeficiency viruses. | upper respiratory tract diseases (urtd) are common clinical problem in cats worldwide. feline calicivirus (fcv) and feline herpesvirus type 1 (fhv-1) are the main primary pathogens. feline immunodeficiency virus (fiv) and feline leukemia virus (felv) are also among the most common infectious diseases of cats which suppress the immunity. oropharyngeal and conjunctival swabs and blood samples were taken from 16 cats with clinical signs of urtd and 26 clinically healthy cats. pcr and rt-pcr were us ... | 2014 | 25610576 |
| clinical and antiviral effect of a single oral dose of famciclovir administered to cats at intake to a shelter. | although famciclovir is efficacious in feline herpesvirus type 1 (fhv-1)-infected cats, effects of a single dose early in disease course have not been reported. in this two part, randomized, masked, placebo controlled study, cats received a single dose of 125 mg famciclovir (n = 43) or placebo (n = 43; pilot study), or 500 mg famciclovir (n = 41) or placebo (n = 40; clinical trial) on entering a shelter. fhv-1 pcr testing was performed, bodyweight and food intake were recorded, and signs of resp ... | 2015 | 25542064 |
| limited efficacy of topical recombinant feline interferon-omega for treatment of cats with acute upper respiratory viral disease. | despite a lack of controlled studies confirming its efficacy, recombinant feline interferon-omega (rfeifn-ω) is used in the treatment of feline upper respiratory tract disease (furtd), which is usually caused by feline calicivirus (fcv) or feline herpesvirus-1 (fhv-1). the aims of the present study were to investigate whether administration of rfeifn-ω improves clinical signs in cats with acute furtd and whether this treatment reduces shedding of fcv. thirty-seven cats affected with acute furtd ... | 2014 | 25457261 |
| effect of ciclosporin and methylprednisolone acetate on cats previously infected with feline herpesvirus 1. | feline herpesvirus 1 (fhv-1) is a common ocular and respiratory pathogen of cats that can be associated with recurrent clinical signs of disease. ciclosporin (cyclosporine) is commonly administered per os (po) for the treatment of a number of inflammatory diseases in cats. a number of client-owned cats administered ciclosporin (cyclosporine) a (csa) po to block renal transplant rejection have developed clinical signs of upper respiratory tract disease that may have been from activated fhv-1. in ... | 2015 | 25204453 |
| efficacy of passively transferred antibodies in cats with acute viral upper respiratory tract infection. | a commercial hyperimmune serum, containing antibodies against feline calicivirus (fcv), feline herpesvirus 1 (fhv-1), and feline panleukopenia virus, is available for treatment of cats with feline upper respiratory tract disease (furtd), but its efficacy has not been rigorously evaluated in scientific studies. the aim of this randomised, placebo-controlled, double-blind clinical trial was to evaluate the efficacy of passive immunisation in cats with acute viral furtd caused by fcv and/or fhv-1 i ... | 2014 | 24929533 |
| felid herpesvirus 1 (fhv 1) carriers among urban breeding facilities in wroclaw (poland). | the prevalence of felid herpesvirus 1 (fhv 1) carriers among closed, one-cat breeding facilities in the urban environment of wrocław city between 2011-2013 was investigated. a probe-based real-time pcr was used to detect fhv 1 dna in conjunctival swab extracts. of the 67 breeding cats investigated 14 animals (20.9%) were confirmed to contain fhv 1 specific dna. the herpesvirus dna was detected in eight cats from the group expressing clinical signs of fhv 1 infection (n = 28) and in six clinicall ... | 2014 | 24881276 |
| concurrent administration of an intranasal vaccine containing feline herpesvirus-1 (fhv-1) with a parenteral vaccine containing fhv-1 is superior to parenteral vaccination alone in an acute fhv-1 challenge model. | the administration of intranasal (in) or subcutaneous (sc) vaccines containing modified live feline herpesvirus 1 (fhv-1) offers some level of protection against fhv-1 challenge, but relative efficacy is <100%. in this study, clinical signs and viral shedding in kittens were compared among three groups: (1) kittens vaccinated concurrently with in and sc vaccines containing fhv-1 (group 1, n = 8); (2) kittens vaccinated with a sc fhv-1 vaccine alone (group 2, n = 8), and (3) unvaccinated control ... | 2014 | 24873978 |
| effects of physiologic concentrations of l-lysine on in vitro replication of feline herpesvirus 1. | to evaluate the effects of various concentrations of l-lysine on in vitro replication of feline herpesvirus 1 (fhv-1). | 2014 | 24866513 |
| effect of high-dose ciclosporin on the immune response to primary and booster vaccination in immunocompetent cats. | ciclosporin (atopica oral solution for cats 100 mg/ml; novartis animal health) was recently approved for use in cats with feline hypersensitivity dermatitis. the immunosuppressant effect of ciclosporin on the ability of cats to mount an immune response following vaccination was determined. thirty-two healthy, immunocompetent adult cats (16 cats/group) were treated with either ciclosporin for 56 days at a dose of 24 mg/kg once daily or sham dosed. prior to treatment, cats had an adequate antibody ... | 2015 | 24820998 |
| severe, diffuse fibrinonecrotic pleuropneumonia in a cat affected by multiple viral infection. | this communication describes the coinfection with feline panleukopenia virus (fpv), feline herpesvirus 1 (fehv-1), feline calicivirus (fcv) and feline coronavirus (fcov) in a 1 year‑old domestic cat living in a feline shelter. the cat was referred to veterinary hospital with clinical signs related to diffuse gastro-intestinal inflammation, it had developed a severe pneumopathy with fibrinous exudation in all body cavities and died 8 days after initial presentation. pathological findings and biom ... | 2014 | 24817332 |
| prevalence of viral infections in cats in southwestern poland in the years 2006 to 2010. | this study included data from 676 cats in southwestern poland examined between 2006 and 2010. examinations were performed to diagnose the following infections: feline leukemia virus (felv), feline immunodeficiency virus (fiv), feline coronavirus (fcov), feline calicivirus (fcv), and feline herpesvirus (fhv). the presence of antibodies or antigens was assessed in samples from all cats. among examined cats, 46.9% were positive for fcv, 50% for fhv, and 38.5% for fcov. retroviral infections were de ... | 2014 | 24693663 |
| isolation and identification of feline herpesvirus type 1 from a south china tiger in china. | in 2012, an fhv-1-like virus was isolated from a tiger that presented with clinical signs of sialorrhea, sneezing and purulent rhinorrhea. isolation was performed with the fk81 cell line, and the virus was identified by pcr, transmission electron microscopy (tem), and the phylogenetic analysis of the partial thymidine kinase (tk) and glycoprotein b (gb) genes. a total of 253 bp of the tk gene and 566 bp of the gb gene were amplified from the trachea of the tiger by pcr/rt-pcr method. phylogeneti ... | 2014 | 24590411 |
| controlled release delivery of penciclovir via a silicone (med-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture. | herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. feline herpesvirus-1 (fhv-1), a member of the alphaherpesvirus family, causes respiratory illness and conjunctivitis, and approximately 80% of domestic cats are latently infected. oral administration of famciclovir or topical application of cidofovir has been shown in masked, placebo-controlled prospective trials to reduce clinical signs and viral shedding in experimentally inoculated cats. ... | 2014 | 24558980 |
| superficial keratectomy for chronic corneal ulcers refractory to medical treatment in 36 cats. | to review the outcome of a case series in which superficial keratectomy was used as a treatment for chronic corneal ulceration. | 2015 | 24548614 |
| evaluation of an in-house dot enzyme-linked immunosorbent assay to detect antibodies against feline panleukopenia virus. | measuring antibody titres to determine a cat's immunity to core diseases instead of just administering annual vaccinations has not been established in germany so far. an in-house test kit for the detection of antibodies against feline panleukopenia virus (fpv), feline herpesvirus-1 and feline calicivirus-- the immunocomb feline vaccicheck--is now available in several european countries. the aim of this study was to assess the quality of the immunocomb feline vaccicheck to determine antibodies by ... | 2014 | 24496322 |
| ocular manifestations of feline viral diseases. | feline viral diseases are common and cats can be presented with a variety of clinical manifestations. ocular disease associated with viral pathogens is not unusual, particularly with viruses causing upper respiratory tract disease in cats, such as feline herpesvirus type 1 and feline calicivirus. these agents mainly cause ocular surface disease. other viruses, such as feline immunodeficiency virus and feline coronavirus, can cause uveitis, while feline leukemia virus can induce ocular lymphosarc ... | 2014 | 24461645 |