| recent concepts of respiratory regulation (author's transl). | there are two functional aspects of the respiratory control system, the one being adaptation of ventilation to metabolic needs and the other acid-base homeostasis of the extracellular fluid of the brain. these two functions are perfectly compatible with one another under normal conditions. during hypoxia or hyperthermia, however, a compromise has to be reaches by the system between securing oxygen availability or homeothermy, respectively and acid-base homeostasis of the brain. the control syste ... | 1977 | 17949 |
| comparative pharmacological studies on beta-adrenolytic agents. an analysis of quantitative activity (author's transl). | | 1977 | 18159 |
| the cools and van rossum theory and the pharmacology of huntington's chorea. | | 1977 | 18317 |
| quantitative histochemical mapping of candidate transmitter amino acids in cat cochlear nucleus. | | 1977 | 18539 |
| evidence that acetylcholine releases noradrenaline in the sympathetic fibre. | | 1977 | 18567 |
| adrenergic receptor mechanisms involved in the hyperglycemia and hyperlactic-acidemia produced by sympathomimetic amines in the cat. | | 1977 | 18597 |
| nature of the rabbit acrosome reaction-inducing activity of follicular fluid. | follicular fluid samples from rabbits, cats, pigs, women and cows had acrosome reaction-inducing activity (aria) on rabbit spermatozoa as determined by differential staining after incubation with these fluids. activity was retained after dialysis and at least 50% was found to be labile when heated to 56 degrees c for as little as 20 min. the induction of the acrosome reaction by bovine follicular fluid showed a dependence on the concentration of follicular fluid and spermatozoa and on calcium io ... | 1977 | 18603 |
| effect of kinins on the action of agonists and antagonists of adrenergic receptors. | | 1977 | 18724 |
| stimulation and excitability in functional syndromes. | | 1976 | 18853 |
| transmitter background of an emotional reaction of the cat proceedings. | | 1977 | 18870 |
| effects of microiontophoretically applied putative transmitters on cortical neurons under conditioning proceedings. | | 1977 | 18874 |
| interaction of dopaminergic and cholinergic neurons in the extrapyramidal and limbic systems. | | 1977 | 18888 |
| pathogenesis of otitis media. | | 1977 | 18976 |
| identification and partial characterization of phospholipases in isolated adrenocortical cells. the effects of synacthen corticotropin-(1--24)-tetracosapeptide and calcium ions. | phospholipase a activity was determined in homogenates and subcellular fractions of trypsin-dispersed cat adrenocortical cells. at ph 7.4 homogenate phospholipid hydrolysis was activated by added ca2+ and inhibited by egta. phospholipid degradation in the presence and absence of synacthen was completely blocked by egta. ca2+-dependent activation of a membrane-bound phospholipase may be a critical control mechanism for regulating the molecular changes taking place during stimulation by synacthen. | 1977 | 19012 |
| behavioral effects of lsd in the cat: proposal of an animal behavior model for studying the actions of hallucinogenic drugs. | in the course of examining the complete dose-response relationship for the behavioral effects of lsd in the cat, we discovered that, in addition to large increases in investigatory and hallucinatory-like responses, two behaviors, not previously reported, are emitted with a high probability under lsd. beginning from a baseline of essentially zero in saline-treated animals, limb flicks and abortive grooming increase in frequency in direct relation to the dose of lsd administered (2.5, 10, 25 and 5 ... | 1977 | 19128 |
| mechanism of action of antihypertensive agents. | | 1977 | 19198 |
| central action of beta-adrenoreceptor blocking agents. | | 1977 | 19201 |
| hypothalamic action of adrenoreceptor blocking agents. | in cats anaesthetized with pentobarbital sodium, the posterior hypothalamus was superfused and electrically stimulated with a push-pull cannula. the pressor response to stimulation of this hypothalamic area was inhibited when the hypothalamus was superfused with drugs blocking either alpha-adrenoreceptors (piperoxan, tolazoline), or beta-adrenoreceptors--(+/-)-propranolol, (-)-propranolol, practolol, sotalol, metoprolol. (+)-propranolol and a concentration of procaine equianaesthetic to proprano ... | 1977 | 19202 |
| lack of hepatic enzymatic adaptation to low and high levels of dietary protein in the adult cat. | the activities of three urea cycle enzymes, several nitrogen catabolic, gluconeogenic, and lipogenic enzymes were measured in the liver of adult cats fed: a commercial kibble; a 17.5 or 70% protein purified diet, or starved for 5 days. except for an increase in tyrosine transaminase (ec 2.6.1.5) after feeding the high protein diet, there were no changes in the activities of the hepatic enzymes as influenced by dietary protein level. likewise, starvation had a minimal effect on the activities of ... | 1977 | 19238 |
| inhibitory effect of fentonium on gastric acid secretion in different laboratory animals. | the influence of fentonium, a new derivative of hyoscyamine, on the gastric secretion has been evaluated in rats, cats and dogs. the compound appeared to be able to markedly reduce the gastric hypersecretion produced by pentagastrin, caerulein and bethanechol; its antagonizing activity against histamine stimulation was poor. | 1977 | 19285 |
| maintenance of respiration by central neural feedback mechanisms. | | 1977 | 19302 |
| pathogenesis of hepatic encephalopathy (author's transl). | this contribution presents data from the literature as well as our own results concerning the mechanisms of hepatic encephalopathy (he). 1. blood chemistry: in patients with liver cirrhosis, the plasma levels of ammonia, phenylalanine, tyrosine, phenolic acids, and octopamine correlated with the stages of he. methionine and free tryptophan concentrations were increased only in stages 2-4. further, branched chain amino acids were below the normal range. experimental findings in animals elucidated ... | 1977 | 19666 |
| delayed development of beta-adrenergic block during sustained administration of thioridazine. | | 1977 | 19759 |
| plasticity in mammalian skeletal muscle. | while it has been recognized for many years that different limb muscles belonging to the same mammal may have markedly differing contractile characteristics, it is only comparatively recently that it has been demonstrated that these differences depend upon the motor innervation. by appropriately changing the peripheral nerve innervating a mammalian skeletal muscle, it is possible to change dramatically the contractile behaviour of the reinnervated muscle. the manner by which the motor innervatio ... | 1977 | 19784 |
| plasticity in the adult vestibulo-ocular reflex arc. | human subjects with maintained reversal of their horizontal field of vision exhibit very substantial adaptive changes in their 'horizontal' vestibulo-ocular reflex (v.o.r.). short durations (8 min) of vision reversal during natural head movement led to 20% v.o.r. attenuation while long periods (4 weeks) eventually led to approximate reversal of the reflex. the reversed condition is approached by a complex, but highly systematic, series of changes in gain and phase of the reflex response relative ... | 1977 | 19786 |
| the presence of ineffective synapses and the circumstances which unmask them. | in this paper, we shall show that there are substantial numbers of nerve terminals which are normally ineffective. in the intact animal, occasional signs of the postsynaptic effectiveness of these fibres can be seen under conditions of optimal spatial summation or increased excitability or decreased inhibition. if the normally functioning afferent nerve fibres are blocked or cut, some of the previously ineffective fibres immediately establish an effective drive of cells. if the normal afferents ... | 1977 | 19789 |
| functional aspects of plasticity in the visual system of adult cats after early monocular deprivation. | | 1977 | 19792 |
| genetic instructions and developmental plasticity in the kitten's visual cortex. | | 1977 | 19793 |
| arterial hydrogen ion versus co2 on depth and rate of breathing in decerebrate cats. | arterial blood hydrogen ion concentration (ha+) was altered over the range of 25 to 110 nm (ph 7.60 to 6.96) by slow intravenous infusion of 1.0 n nahco3 or 0.5 n hc1 at controlled levels of paco2in unanesthetized decerebrate cats. respiratory f varied as a single function of vt irrespective of a lterations in paco2 and ha+ even after interruption of the carotid sinus nerves. the dependence of f upon vt was abolished by vagotomy. however, vt continued to respond to changes in ha+ over its entire ... | 1977 | 19831 |
| the effect of dehydroemetine on vascular tissue. | the effect of dehydroemetine on vascular tissues was studied, using the aortic strip of the rabbit, the isolated perfused central ear artery of the rabbit and the perfused hind limb of the cat. doses from 10(-6) to 10(-5) m inhibited the response of the aortic strip and the perfused ear artery to transmural electrical stimulation. 10(-5) m dehydroemetine completely blocked the response of the aortic strip to transmural stimulation. this dose however, had no significant effect on the response to ... | 1976 | 19879 |
| reduced sensitivity to alpha- and beta-adrenergic receptor agonists of intra- and extracranial vessels during pregnancy. relevance to migraine. | | 1977 | 19910 |
| the behavior of local ph and nadh-fluorescence during and after direct activation of the brain cortex. | | 1977 | 19911 |
| are h+ and k+ factors for the adjustment of cerebral blood flow to changes in functional state: a microelectrode study. | | 1977 | 19912 |
| dependency of the dilatatory action of adenosine on the perivascular h+ and k+ at pial arteries of cats. | | 1977 | 19913 |
| action of dopamine agonists on brain vessels in vitro and after in vivo microapplication. | | 1977 | 19914 |
| introductory remarks: oxygen linked response of carotid chemoreceptors. | | 1977 | 19936 |
| cerebral hemodynamic and metabolic alterations in stroke. | | 1977 | 19940 |
| atypical (relaxant) response to histamine in cat bronchus. | histamine, 2-methylhistamine (a specific h1-receptor agonist), 4-methylhistamine (a specific h2-receptor agonist), isoprenaline, bradykinin, prostaglandin e1, e2, and f 2alpha induce relaxation of carbachol-contracted isolated cat bronchial strips and tracheal chains. bovine srs-a contracts bronchus but not trachea. histamine-induced relaxation of cat bronchus is not blocked by mepyramine (a specific h1-receptor antagonist); metiamide or burimamide (specific h2-receptor antagonists); propranolo ... | 1977 | 19953 |
| regulation of alpha- and beta-adrenoreceptor activity in the myometrium. | | 1977 | 19981 |
| an experimental study of the effectiveness of various antireflux operations. | | 1977 | 20065 |
| species differences in erythrocyte resistance against decrease of ph values. | | 1977 | 20076 |
| factors affecting the tissue binding of nicotine in various species. | | 1977 | 20108 |
| bufuralol, a new beta-adrenoceptor blocking agent in a series of benzofuran-2-ethanolamines. part 2: pharmacology. | 1-(7-ethylbenzofuran-2-yl)-2-tert.-butylamino-1-hydroxyethane hydrochloride (bufuralol) is a non-selective beta-adrenoceptor blocking agent which closely resembles propranolol in its properties, including potency. bufuralol is devoid of alpha-adrenoceptor blocking activity but possesses beta-adrenoceptor agonist activity. beta-adrenoceptor blocking activity resides mainly in the (-)-isomer though membrane stabilising properties are associated with both optical isomers. | 1977 | 20114 |
| mechanism of cardiovascular changes produced in cats by activation of the central nervous system with picrotoxin. | | 1977 | 20241 |
| cyclic 3'5'-adenosine monophosphate and central circulatory control in cats and dogs. | 1. dibutyryl cyclic amp (db camp, 75-500 microgram/kg), injected into the lateral ventricle of the brain of the cat increased blood pressure, heart rate and splanchnic discharge rate. 2. atp, but not amp, induced similar changes; gmp in small doses increased blood pressure. 3. a number of drugs are known to activate adenylate cyclase-induced hypertension, tachycardia and increase splanchnic discharge rate. this was shown for trh, tetracosactide and a new beta2-adrenoceptor stimulant, nab 365. 4. ... | 1977 | 20256 |
| comparative biochemical studies of placental alkaline phosphatase in animals (author's transl). | biochemical properties of alkaline phosphatase (alp) from placenta were compared between man, dog, cat, rabbit and cattle. 1) optimum ph of the enzyme was essentially identical through the species of the animals but the inhibition of l-phenylalanine was clearly demonstrable with human alp but little with that of other animals. 2) alp of human placenta was not inactivated by heating at 65 degrees c for 15 min. but one of the other animals was thermolabile. such thermostability of human placental ... | 1977 | 20315 |
| pharmacologic study of clofelin. | clofelin--2-(2,6-dichlorphenylamino)-2-imidasoline, an analoque of foreign-made clonidine (st155, catapresan, hemiton, etc) was subjected to a pharmacological study. in animals the drug produces first a rise and then protracted fall of the arterial pressure, reduces the frequency of cardiac contractions, lessens reflex hypertension that develops on compression of carotid arteries. when used in low doses it depresses the motor activity in unanesthetized animals and produces symptoms that bear evi ... | 1977 | 20325 |
| mechanism of the antianginal action of oxyfedrine. | oxyphedrine was found to depress the tonicity of coronary vessels, increase the coronary circulation volume, the oxygen uptake by the heart and also to exert a positive inoand chronotropic action in test with urethan and cloralose anesthetized cats. these effects were caused by stimulation of the beta-adrenoreceptors of the heart and vessels. in non-anesthetized cats oxyphedrine did not produce tachycardia. furthermore, under certain conditions (when superimposed on a preliminary administration ... | 1977 | 20326 |
| comparative study between dobutamine and other catecholamines in their effects on the cardiac contraction and rhythm (author's transl). | dobutamine (dob) showed a dose dependent positive introphic effect on the right ventricular muscle of vagotomized beagle dogs under pentobarbital anesthesia. positve inotropic effects of other catecholamines (ca) decreased in the following order; isoproterenol (iso, 115) greater than norepinephrine (ne, 15) greater than dob (1) greater than dopamine (da, 0.36). brachiocephalic arterial flow was also increased by dob with a positive inotropic effect in the right ventricular muscle. though the pos ... | 1977 | 20396 |
| postcapillary changes in blood ph in vivo during carbonic anhydrase inhibition. | a rapidly responding stopped-flow glass ph electrode apparatus was used to investigate ph changes in blood in vivo after it exits from an exchange capillary. arterial blood was drawn from anesthetized animals through the apparatus. temperature and ph of the blood in the electrode chamber were continuously recorded, both during withdrawal and after flow was stopped. blood ph did not change after stopping flow in control experiments. when benzolamide (2 mg/kg) was given to inhibit carbonic anhydra ... | 1977 | 20440 |
| beta-adrenergic blocking agents. 16. 1-(acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols. | the synthesis of a series of 1-(acylaminomethyl-, ureidomethyl-, and ureidoethylphenoxy)-3-amino-2-propanols is described. the compounds were screened as beta-adrenergic receptor antagonists in cats and their partial agonist activity was evaluated in rats depleted of circulating catecholamines. some of the compounds have a pharmacological profile similar to atenolol. their structure-activity relationships are discussed. | 1977 | 20502 |
| occurrence of nerves containing vasoactive intestinal polypeptide immunoreactivity in the male genital tract. | | 1977 | 20541 |
| effects of db camp on tyrosine hydroxylase activity of ganglia and nerve endings. | preincubation of intact superior cervical ganglia or nictitating membrane for 2 h with dibutyryl cyclic amp (db camp) increased the hydroxylation of tyrosine. this effect was not blocked by the protein synthesis inhibitor, cycloheximide. the km of tyrosine hydroxylase for the substrate, tyrosine, and for the cofactor, reduced pteridine, were decreased by db camp. there were no changes in the vmax of the enzyme. the inhibitory potency of noradrenaline on the hydroxylation of tyrosine was also dec ... | 1977 | 20583 |
| a newly recognized pancreatic polypeptide; plasma levels in health and disease. | | 1976 | 20650 |
| the effect of sympathomimetric drugs on exocrine pancreatic function. studies in the isolated cat pancreas (author's transl). | this study reports on effects of beta-sympathomimetic drugs on the exocrine function of the isolated cat pancreas. the injection of these drugs resulted in an increase of pancreatic protein and enzyme secretion, the excretion of calcium into the juice and the rate of volume output were not changed. the enzyme secretion was inhibited by different adrenolytic drugs (phenoxybenzamine, practolol, butoxamine), by tetracain, hemicholinium, and atropine. the pancreatic function of cats pretreated by re ... | 1977 | 20653 |
| inhibitory processes in the cerebral cortex and the anticonvulsive action of benzodiazepine derivatives. | a comparative study of the effect of some benzodiazepine deprivatives (chlonazepam, lorazepam, diazepam, and medazepam) on the recovery cycles of the interzonal response was carried out on unanesthetized curare-immobilized cats. these drugs proved to selectively inhibit the testing potential within the range of 20 to 100 msec. between the conditioning and the testing stimuli. this indicates that potentiation of gaba-ergic inhibition in the cerebral cortex. the threshold doses of the drugs induci ... | 1977 | 21007 |
| analysis of the effect of bicarbonate on taste receptor sensitivity to organic acids. | addition of nahco3 or naoh to the solutions of lactic or pyruvic acids decreased threshold concentrations of h+ ions and increased intensity of afferent impulsation in the cat chroda tympani nerve. in spite of the fact that the concentrations of both lactate and pyruvate anions with the presence of naoh and nahco3 are the same at equal ph values the observed changes of the receptors responses were more intensive if nahco3 had been added. therefore the influence of nahco3 on the perception of org ... | 1977 | 21106 |
| effects of a new minor tranquilizer, 10-chloro-3-methyl-1 1b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo 6,7-1,4-diazepino 5,4-b-oxazol-6-one (cs-386), on the after-discharge and behavior induced by electrical stimulation of the amygdala in freely-moving cats (author's transl). | effects of a new minor tranquilizer, cs-386, on the after-discharge(ad) and behavior induced by amygdaloid electrical stimulation in freely-moving cats were compared with those of cloxazolam, oxazolam, diazepam, chlordiazepoxide, phenobarbital and chlorphromazine. effects on change of the ad threshold and duration and on facial twitching, salivation and tonic-clonic convulsion were investigated. cs-386, cloxazolam and oxazolam inhibited amygdaloid ad. cs-386 had the most potent inhibitory effect ... | 1977 | 21125 |
| ganglion blocking activity of a series of semisynthetic quaternary pyrrolizidines. | | 1977 | 21136 |
| comparative studies on membranes from bovine choroid plexus and rat kidney cortex. | | 1977 | 21337 |
| centrally active drugs and the sympathetic nervous system of rabbits and cats. | | 1977 | 21359 |
| the anionic permeability of the inhibitory postsynaptic membrane of hippocampal pyramidal cells. | | 1977 | 21395 |
| the ionic mechanisms concerned in generating the i.p.s.ps of hippocampal pyramidal cells. | | 1977 | 21396 |
| interneuronal synapses with electrical and chemical mechanisms of transmission and the evolution of the central nervous system. | it becomes increasingly evident that not only chemical but also electrotonic synapses are characteristic feature of the vertebrate brain. experiments carried out on the isolated perfused central nervous system of lampreys and frogs have shown that in cyclostomes spinal motoneurons receive at least 4 different electrotonic inputs: from giant reticulospinal axons, from smaller descending fibers intrinsic to the cord, from primary afferents and ventral roots. in amphibian motoneurons it is possible ... | 1977 | 21498 |
| coparative pharmacological study of new adrenergic beta receptor blocking aromatic derivatives of oxybutanolamine and trasicor. | | 1977 | 21514 |
| the brain as a dream state generator: an activation-synthesis hypothesis of the dream process. | recent research in the neurobiology of dreaming sleep provides new evidence for possible structural and functional substrates of formal aspects of the dream process. the data suggest that dreaming sleep is physiologically determined and shaped by a brain stem neuronal mechanism that can be modeled physiologically and mathematically. formal features of the generator processes with strong implications for dream theory include periodicity and automaticity of forebrain activation, suggesting a prepr ... | 1977 | 21570 |
| experimental interaction of narcotic substances and hypoxia. | | 1977 | 21602 |
| autacoid and anaphylactic reactivity of pulmonary and hepatic smooth musculature of the cat. | histamine, 2-methylhistamine (2-meh: a relatively specific h1 receptor agonist), 5-ht, carbachol, bradykinin (bk) and pgf2alpha contract isolated cat pulmonary vein, artery and hepatic vein. pge1, pgf2alpha and 4-methylhistamine (4-meh: a relatively specific h2-receptor agonist) contract pulmonary arterial strips but further increase in the dose of pge1 produces relaxation. isoproterenol relaxes partially contracted blood vessels at low doses, but contracts at high doses. cat trachea contracts t ... | 1977 | 21798 |
| mechanism of the cardiotoxic action of no-spa. | tests set up in vivo on rats and with an isolated spontaneously contracting atrium of the cat brought evidence that nospanum produces an adverse chronotropic action, caused by a direct effect on the cardiac pacemaker. in the rat's myocardium the drug raised the pyruvate level, increased the lactate-dehydrogenase activity and depressed that of glucose-6-phosphate-dehydrogenase. as established by differential spectrophotometry the reduced forms of pyridine-nucleotides (nad'n, nadp'n) tend to chang ... | 1977 | 21807 |
| interactions between perivascular norepinephrine and potassium or osmolarity on pial arteries of cats. | | 1977 | 22024 |
| local glucose utilization in acute focal cerebral ischemia: local dysmetabolism and diaschisis. | by means of an autoradiographic technique employing 14c-2-deoxyglucose, abnormalities of local brain glucose utilization were studied 90 minutes following occlusion of the left middle cerebral and common carotid arteries in a series of pentobarbital-anesthetized cats. sham-insulted control animals exhibited a normal pattern of regional glucose utilization. in animals with vascular occlusion, a zone of greatly suppressed glucose utilization occupied the caudate nucleus of the ischemic hemisphere, ... | 1977 | 22053 |
| interactions interfering with central adrenoreceptor activity and hypotension of centrally acting antihypertensive agents. | | 1977 | 22093 |
| amino acid transmitters (author's transl). | | 1977 | 22097 |
| monoaminergic mechanisms in the regulation of sleep--waking cycle (author's transl). | | 1977 | 22101 |
| mating behavior in the cat. | | 1977 | 22153 |
| the distribution of enzymes in the epidermis of the domestic cat. | with the help of enzyme histochemical methods, the distribution and activities of several oxidative and hydrolytic enzymes in the epidermis of the densely-haired domestic cat have been studied. distinct oxidative enzyme activity could be demonstrated in all epidermal layers except the stratum corneum. among the hydrolytic enzymes investigated, strong reactions for non-specific esterases were visible especially in the str. granulosum and the basal lamellae of the str. corneum. positive reactions ... | 1977 | 22312 |
| characterization of the adrenergic activity of carbuterol (sk&f 40383-a). | carbuterol is a beta-adrenergic bronchodilator with selectivity for bronchial smooth muscle relative to cardiac and vascular tissues of several species including man. the present studies were undertaken to further characterize its adrenergic profile. in vitro studies demonstrated that carbuterol was a direct acting beta-adrenergic agonist, not dependent on endogenous catecholamine release, and was devoid of alpha-adrenergic agonist activity. the activity of the racemate was shown to reside prima ... | 1977 | 22441 |
| peripheral cardiovascular dopamine receptors. | | 1977 | 22476 |
| lipotropin and the central nervous system. | | 1977 | 22510 |
| changes in vascular reactivity in experimental hypertensive animals following treatment with indapamide. | | 1977 | 22620 |
| bupropion hydrochloride ((+/-) alpha-t-butylamino-3-chloropropiophenone hcl): a novel antidepressant agent. | | 1977 | 22628 |
| 2,4-dinitrophenol inhibition of transport of 5-hydroxyindoleacetic acid from the cerebrospinal fluid and spinal cord. | | 1977 | 22630 |
| the effects of amikacin on autonomic and neuromuscular transmission proceedings. | | 1977 | 22682 |
| neuromuscular and autonomic actions of four chandonium analogues proceedings. | | 1977 | 22715 |
| the ph of brain extracellular fluid in the cat. | 1. the blood supply to the medulla was determined by the injection of indian ink via the vertebral arteries. virtually the whole medulla was supplied by penetrating vessels from the ventral surface. the highest density of small arterioles and venules was found close to the roots of xii and on the ventrolateral surface.2. the ph of extracellular fluid (ph(e.c.f.)) was measured with ph microelectrodes of tip size 1-3 mum in cortex and medulla in seventeen cats, anaesthetized with pentobarbitone or ... | 1977 | 22741 |
| effect of 4-aminopyridine on release of noradrenaline from the perfused cat spleen by nerve stimulation. | 1. 4-aminopyridine (4-ap, 1 mm) increased noradrenaline (na) output from the perfused cat spleen at 5 hz by about fivefold. enhancement of na release by 4-ap was reversible. output of na induced by potassium was not affected. 2. na output was doubled at low concentrations (0.1--0.3 mm) of 4-ap, but maximal effect was obtained at 1--3 mm. at 10 mm, it induced spontaneous release of na which was insensitive to calcium. 3. insignificant outputs obtained at 5 hz in 0.1 and 0.3 mm calcium-krebs solut ... | 1977 | 22746 |
| beta-adrenergic blocking agents. 17. 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols. | the synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. the compounds were investigated for their beta-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized cats for their effects on an isoproterenol-induced tachycardia and depressor response. the structure-activity relationship shown by this series of compounds is related to that of kn ... | 1977 | 22750 |
| adrenoceptor blocking agents. 2. 2-(alpha-hydroxyarylmethyl)-3,3-dimethylaziridines, a new class of selective beta2-adrenoceptor antagonists. | threo- and erythro-2-(alpha-hydroxybenzyl)-3,3-dimethylaziridines (1a and 1b) and threo-2-alpha-hydroxy(2-naphthyl)methyl- and 2-alpha-hydroxy(3,4-dichlorobenzyl)-3,3-dimethylaziridines (1d and 1c) have been prepared as conformationally restricted analogues of beta-adrenoceptor blocking agents like dichloroisoproterenol (dci) and pronethalol. the aziridine analogues 1 except possibly 1c are competitive antagonists of isoproterenol-induced response on a guinea pig tracheal chain preparation and t ... | 1978 | 22756 |
| response time of cerebral arterioles to alterations in extravascular fluid ph. | | 1977 | 22802 |
| d-alpha-aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones. | | 1977 | 22820 |
| pharmacological characterization of b-ht 933 (2-amino-6-ethyl-4,5,7,8,-tetrahydro-6h-oxazolo-5,4-d-azepindihydrochloride) as a hypotensive agent of the "clonidine-type". | | 1977 | 22821 |
| differentiation of cardiac chronotropic and inotropic effects of beta-adrenoceptor agonists. | the relative inotropic and chronotropic activity of beta-adrenoceptor agonists was studied in the noradrenaline-depleted, anaesthetized cat. terbutaline, a selective beta2-adrenoceptor agonist, gave at a certain dose a more pronounced chronotropic than inotropic response, while a new beta1-selective adrenoceptor agonist (-)-h 80/62 produced the same degree of chronotropic and inotropic stimulation. the results indicate that there is some difference between the beta-adrenoceptors in the sinus nod ... | 1977 | 22823 |
| the use of microelectrodes for measurement of local h+ activity in the cortical subarachnoidal space of cats. | ph microelectrodes with pointed tip (hinke-type) were constructed for the continuous measurement of the local ph in the perivascular space of pial arteries in the feline cerebral cortex. the sensitive tip had a length of 20-60 mu and a base diameter of 10-25 mu. as reference electrode, a micropipette (tip diameter 2 mu), filled with 150 mm kcl was used. calibration curves were linear and showed a sensitivity of 54.5-57.5 mv/ph unit at 38 degrees c. advantages of such electrodes are the easy pene ... | 1977 | 22841 |
| the nature of the boundary between cortical visual areas ii and iii in the cat. | | 1977 | 22869 |
| central nervous respiratory depressants--narcotic analgesics. | | 1977 | 22878 |
| characterization of the beta-adrenergic receptors in the lower urinary tract of the cat. | the corpus-fundus and the outlet region of the urinary bladder of the cat was studied in vitro to characterize the beta-adrenergic receptors. in the corpus-fundus only beta1-receptors were found in contrast to the outlet region where the beta-receptors had both beta1-and beta2-characteristics. | 1977 | 22927 |
| urinary ph effects of diet additives. | | 1977 | 22951 |
| a cat head model with isolated perfusion by the animal's own blood. | a model consisting of a cat head perfused in isolation with the animal's own blood is described. the use of endogenous blood allows the organ to function under physiological conditions for several hours. the blood is taken from the abdominal aorta of the anaesthetized animal and passed to the carotid arteries via an extracorporeal circulation system. the perfusion pressure can be varied at will and is regulated electronically. the volume of blood in the extracorporeal circulation system is only ... | 1977 | 23001 |
| further evidence for gaba-ergic mechanisms in the action of benzodiazepines. | drugs of the benzodiazepine series (clonazepam, lorazepam, diazepam and medazepam) increase the inhibitory processes in the cerebral cortex as it has been shown by means of the recovery cycles of the intracortical response. there is a correlation between the effect on the recovery cycles and their protective action against convulsions induced by gaba deficit. diazepam enhances the inhibitory effect of gaba applied iontophoretically to rabbit sensorymotor cortex neurons. the drug gaba-ergic effec ... | 1977 | 23084 |
| regulation of microflow and behaviour of local tissue po2 during activation and anoxia of the brain cortex. | | 1977 | 23095 |