| intracellular calcium and ventricular function. effects of nisoldipine on global ischemia in the isovolumic, coronary-perfused heart. | ischemia-induced ventricular dysfunction has been shown to be associated with increased diastolic and systolic intracellular concentrations of free, ionized calcium ([ca2+]i). the present study was designed to determine the effects of the ca2+ antagonist nisoldipine on the relationship between [ca2+]i and left ventricular contraction and relaxation during ischemia and reperfusion on a beat-to-beat basis. nine isovolumic coronary-perfused ferret hearts were made globally ischemic for 3 min and re ... | 1992 | 1602012 |
| changes in intracellular free calcium concentration during long exposures to simulated ischemia in isolated mammalian ventricular muscle. | intracellular free calcium concentration ([ca2+]i) was measured in isolated ferret ventricular papillary muscles during and after long exposures to ischemia. all experiments were performed at 37 degrees c, and the muscles were stimulated at 1 hz. ischemia was simulated by changing from superfusion with oxygenated tyrode's solution to superfusion with water-saturated gas (95% n2-5% co2), thus simultaneously stopping oxygenation and restricting the extracellular space. [ca2+]i was measured with ae ... | 1992 | 1606668 |
| rapid development of the auditory brainstem response threshold in individual ferrets. | the development of the ferret auditory system was examined using the auditory brainstem response (abr). longitudinal recordings were obtained under short-acting anaesthesia from individual animals at 4-h or 24-h intervals. particular attention was focused on the period from postnatal day (p) 26 to p32 when the ferret auditory system becomes functional. abr thresholds to click stimuli presented in a free-field were found to decline precipitously within a 4-h period during the first 24 h following ... | 1992 | 1606688 |
| pyloric adenocarcinoma in a ferret. | pyloric adenocarcinoma was diagnosed in a ferret with clinical signs of gastric distention. the development of this tumor may be related to helicobacter mustelae infection in the gastric mucosa of ferrets. pyloric adenocarcinoma has only recently been reported in ferrets and should be considered as a differential diagnosis for gastric distention in this species. | 1992 | 1607319 |
| zoonoses of house pets other than dogs, cats and birds. | in addition to dogs, cats and birds, which are the most frequent house pets, rabbits, rodents, fish and turtles are also vertebrate species that commonly share the home environment. lizards, snakes and ferrets are less common pets. these species can transmit numerous diseases, especially to children who are more likely to be in close contact with them. the author presents a general review of zoonoses and potential zoonoses transmitted by rabbits, rodents and cold blooded vertebrates. zoonoses tr ... | 1992 | 1608686 |
| effect of mebeverine hydrochloride on jejunal motility and epithelial transport in the anesthetized ferret. | previous in vitro and in vivo studies demonstrate that mebeverine, administered to isolated smooth muscle preparations or given intravenously, (i.v.), acts as an antispasmodic agent and may be useful in treating intestinal hypermotility. whether mebeverine affects intestinal mucosal transport is, however, unknown. the aim of the present study was to characterize the effect of mebeverine on both small intestinal motor activity and electrogenic epithelial transport in the urethane anesthetized fer ... | 1992 | 1612107 |
| an ultrastructural study of helicobacter mustelae and evidence of a specific association with gastric mucosa. | the ultrastructure of helicobacter mustelae, a natural inhabitant of the ferret stomach, has been studied and compared with the human gastroduodenal pathogen h. pylori. h. mustelae is a short, slightly curved rod, 2 microns x 0.5 micron, with four or more sheathed flagella. the most common flagellar configuration is a single flagellum at one terminus, bipolar arrangement at the other end and a lateral flagellum. dense inclusion bodies were observed below the flagellar insertion sites. it is sugg ... | 1992 | 1613782 |
| arachidonic acid increases cholinergic secretory responsiveness of ferret tracheal glands. | the purpose of this study was to determine if arachidonic acid could alter ferret tracheal gland secretory responsiveness to a cholinergic agonist. we prepared glandular explants and incubated the explants in medium containing [3h]glucosamine. secretory responsiveness was expressed as the percent change in basal secretion of acid-precipitable [3h]glucosamine-labeled glycoconjugates induced by the addition of agonist with and without arachidonic acid [mean +/- se (n)]. addition of 10(-3) m arachi ... | 1992 | 1616053 |
| effects of endothelin, platelet activating factor and thromboxane a2 in ferret lungs. | we have compared the effects of three vasoactive agents, endothelin, platelet activating factor and thromboxane a2 analogue, u 46,619, in the pulmonary circulation of ferrets. lungs of nine adult ferrets, body weight 1.06 +/- 0.27 kg, were isolated and perfused with sheep red blood cells suspended in kreb's solution with 2 g% dextran 70 (hematocrit 33 +/- 6%), under conditions of constant flow in zone 3. endothelin-1 (et: 0.1-1.35 micrograms/kg), platelet activating factor (paf: 0.5-5.5 microgra ... | 1992 | 1626132 |
| subacute toxicity and maximum tolerable dose of sertaconazole in repeated administration studies. | 28-day oral and dermal subacute toxicity studies of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1h-imidazol-1-yl) ethoxy-methyl] benzo [b] thiophene (sertaconazole, fi-7045, cas 99592-32-2), were carried out. the oral studies included the evaluation of subacute toxicity in rat (dose levels of 50, 150 and 300 mg/kg) and maximum tolerable dose in repeated administration in ferrets (consecutive dose levels in accordance with a geometric progression of 50, 75, 112.5, 168 and 250 mg/kg), which were the ani ... | 1992 | 1627193 |
| chronic toxicity studies of sertaconazole after oral administration to rats and ferrets. | six-month chronic oral toxicity studies of 7-chloro-3-[1-(2, 4-dichlorophenyl)-2-(1h-imidazol-1-yl)ethoxy-methyl] benzo[b]thiophene (sertaconazole, fi-7045, cas 99592-32-2) were carried out in rats and ferrets. the dose levels used were 50, 150 and 300 mg/kg in rats and 50, 150 and 250 mg/kg in ferrets. there was no mortality associated with the drug in either of the two species. the results obtained show that the toxic effects may be summarized as a smaller body weight increase in rats at 150 a ... | 1992 | 1627194 |
| midline and lateral field sound localization in the ferret (mustela putorius): contribution of the superior olivary complex. | 1. the ability of ferrets to localize sound in space was determined before and after unilateral or bilateral lesions of the superior olivary complex (soc). lesions were made by pressure injection of kainic acid into the soc through a stereotaxically positioned glass micropipette. the lesions destroyed the cell bodies in the superior olive without disrupting fibers of passage in the trapezoid body or other pathways in the auditory brain stem. the integrity of fibers was demonstrated by protargol ... | 1992 | 1629768 |
| visual callosal projections in the adult ferret. | the laminar and tangential organization of visual callosal projections of areas 17 and 18 were investigated in the adult ferret, using histochemical methods to visualize axonally transported horseradish peroxidase (hrp). normal adult ferrets were given injections of hrp throughout one visual cortex or had gelfoam soaked in hrp applied to the transected corpus callosum. the ferret callosal cell distribution has a greater tangential extent in area 18 than in area 17. in addition, the radial organi ... | 1992 | 1633130 |
| action potential duration and endocardial modulation of myocardial contraction in the ferret. | endocardial endothelium releases substances which modulate myocardial contraction. selective endocardial removal abbreviates contraction by removing a contraction prolonging substance "endocardin". the aim of the study was to investigate whether changes in action potential duration underlie these contractile effects. | 1992 | 1638571 |
| strain rate effects on tensile failure properties of the common carotid artery and jugular veins of ferrets. | we have recently reported the insensitivity of tensile failure properties of human cerebral bridging veins to strain rate. due to data scattering, however, concerns remain regarding this finding. to pursue the issue further, the common carotid arteries and external and internal jugular veins from seven ferrets were stretched longitudinally in vitro at either a low strain rate of 0.2-2.0 s-1 or a high rate of approximately 200 s-1. the ultimate stretch ratios and loads were found to be independen ... | 1992 | 1639836 |
| parvovirus-associated syndrome (aleutian disease) in two ferrets. | there is a paucity of information regarding natural aleutian disease, caused by a parvovirus in ferrets. with the increasing popularity of ferrets as household pets and laboratory animals, and with the advent of a usda-approved rabies vaccine, the occurrence and the etiopathogenesis of naturally acquired diseases in ferrets needs to be documented. we present the clinical and laboratory findings associated with aleutian disease in 2 domestic ferrets, one with the chronic wasting form of the disea ... | 1992 | 1644626 |
| okadaic acid, a protein phosphatase inhibitor, increases the calcium transients in isolated ferret ventricular muscle. | okadaic acid is a protein phosphatase inhibitor which has been found to produce a marked positive inotropic effect in isolated cardiac muscle. using aequorin-injected ferret papillary muscles, we demonstrate that the increase in tension seen with okadaic acid is accompanied by a simultaneous increase in the amplitude of the calcium transients. by comparison with the effects of changing the extracellular calcium concentration, it is shown that the increase in calcium transient amplitude can accou ... | 1991 | 1647801 |
| the effects of ph changes on human and ferret detrusor muscle function. | 1. the effects of altering extracellular ph on the electrically evoked contractions of ferret and human bladder (detrusor) smooth muscle have been investigated. ph was varied by changing superfusate pco2 or nahco3 concentration. acidosis increased force when superfusate pco2 was raised but decreased force when the nahco3 concentration was reduced. 2. intracellular ph (phi) in isolated ferret detrusor cells was measured separately by epifluorescence microscopy. extracellular ph changes caused by ... | 1991 | 1653318 |
| the antiemetic profile of y-25130, a new selective 5-ht3 receptor antagonist. | y-25130( (+/-)n-(1-azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro - 2h-1,4-benzoxazine-8-carboxamide hydrochloride) is a potent and selective 5-ht3 receptor antagonist free of dopamine receptor blocking activity. this compound was effective against emesis induced in animals by cytotoxic drugs or by total body x-radiation. when given prophylactically, the doses required to completely inhibit cisplatin-induced emesis in dogs and doxorubicin and cyclophosphamide-induced emesis in fe ... | 1991 | 1654255 |
| spinal dracunculiasis in an experimentally infected ferret. | | 1991 | 1658452 |
| in vitro cytopathogenicity and in vivo virulence of two strains of canine parainfluenza virus. | in vivo and in vitro properties of two strains of canine parainfluenza virus (cpiv) were investigated. one strain, designated cpiv(+), induced syncytial giant cell formation and cytolysis in vitro, whereas the second strain, cpiv(-), caused only a mild strand-forming cytopathic effect with few, small syncytial giant cells. vero cells infected with cpiv(+) or cpiv(-) were 100% positive for cpiv antigen as determined by immunofluorescent staining; however, 100% of cpiv(+) and less than 10% of cpiv ... | 1991 | 1659020 |
| the actions of fentanyl to inhibit drug-induced emesis. | the ability of fentanyl to inhibit drug-induced emesis was investigated in the ferret. initial studies established that morphine, in small doses (0.025-0.5 mg/kg s.c.), induced emesis in the ferret that decreased at the larger doses of 1 and 2 mg/kg (s.c.). fentanyl (10-80 micrograms/kg s.c.) failed to induce emesis but in this dose range prevented the emesis induced by morphine (0.5 mg/kg s.c.), apomorphine (0.25 mg/kg s.c.), copper sulphate (100 mg/kg intragastric) and cisplatin (10 mg/kg i.v. ... | 1991 | 1661861 |
| preliminary evidence for the involvement of the putative 5-ht4 receptor in zacopride- and copper sulphate-induced vomiting in the ferret. | previous studies of the mechanism of zacopride-induced emesis in ferrets have concluded that it is mediated predominantly by an antagonist effect on 5-ht3 receptors although the possibility of a contribution from an agonist effect at 5-ht4 receptors was not excluded. this study shows that zacopride (200 micrograms/kg p.o.)-induced emesis can be blocked by a 'high dose' (1000 micrograms/kg) of ics205930 but not by a low dose (100 micrograms/kg) or by 'high doses' (1000 micrograms/kg) of another m ... | 1991 | 1663456 |
| intranasal infection of ferrets (mustela putorius furo) with canine parainfluenza virus. | immunocompetent and cyclophosphamide-immunosuppressed ferrets were intranasally infected with canine parainfluenza virus (cpiv) and observed for clinical signs, histopathologic lesions, the immunocytochemical demonstration of cpiv antigen in the respiratory tract and scanning electron microscopic alterations of the tracheal epithelium until 36 days post infection (p.i.). in both groups, clinical signs were minimal, restricted to the upper respiratory tract and consisted of cough elicited by trac ... | 1991 | 1663681 |
| organisation of the visceral solitary tract nucleus in the ferret as defined by the distribution of choline acetyltransferase and nerve growth factor receptor immunoreactivity. | the cholinergic innervation of the visceral component of the nucleus of the solitary tract in the ferret was investigated by using choline acetyltransferase immunocytochemistry. the subdivisions of the ferret solitary tract nucleus as defined by nissl architectonics were found to correspond to most of those previously assigned to the cat solitary tract nucleus. the subnuclei of the ferret solitary tract nucleus were also outlined by using immunohistochemical and histochemical methods to stain fo ... | 1991 | 1667621 |
| cisplatin-evoked induction of c-fos protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-ht3 receptor antagonist granisetron (brl 43694). | we have monitored the expression of c-fos protein in the medulla oblongata of the ferret, using immunocytochemistry, to identify the brainstem pathways involved in the mediation of nausea and vomiting caused by the antineoplastic drug cisplatin. cisplatin administration resulted in c-fos-like immunoreactivity (fli) in the area postrema, the nucleus of the solitary tract, and in scattered cells within the ependymal lining of the fourth ventricle. unilateral cervical vagotomy greatly reduced fli i ... | 1991 | 1668810 |
| effect of capsaicin on nasal secretion in anesthetized ferrets. | in urethan-anesthetized ferrets, we investigated the nasal response to capsaicin infused via a catheter inserted retrogradely into the lingual artery. capsaicin dose-dependently increased fluid output from the nose (nasal fluid output) and the lateral nasal gland (glandular fluid output). the secretory response to capsaicin (80 nmol/kg ia) was completely blocked by atropine and hexamethonium, indicating that a cholinergic reflex mediates capsaicin-induced nasal hypersecretion in this model. the ... | 1991 | 1672688 |
| cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. | in order to determine whether the cholinergic fibres that innervate the substantia nigra make synaptic contact with dopaminergic neurons of the substantia nigra pars compacta, a double immunocytochemical study was carried out in the rat and ferret. sections of perfusion-fixed mesencephalon were incubated first to reveal choline acetyltransferase immunoreactivity to label the cholinergic terminals and then tyrosine hydroxylase immunoreactivity to label the dopaminergic neurons. each antigen was l ... | 1991 | 1678502 |
| receptor-mediated camp production in adult and infant ferret tracheal epithelium. | tracheal epithelial cells obtained from adult and infant ferrets were grown in primary culture in vitro. cells from adult animals grew readily, and many ciliated cells were observed in the cultures. successful cultures were derived from infant animals, but cell number in infant and adult cultures began to decrease after 6 d. receptor-mediated activation of adenylate cyclase was determined by incubating monolayers of adult or neonatal cells with beta-adrenergic agonists, prostaglandin e2 (pge2) a ... | 1991 | 1679920 |
| early development of the nucleus basalis-cortical projection but late expression of its cholinergic function. | the aim of this study was to examine the development of the basalocortical pathway by using choline acetyltransferase and nerve growth factor receptor immunocytochemistry, acetylcholinesterase histochemistry and retrograde axonal transport. the observations were made in the ferret because in this species brain development occurs over a much more protracted period than in the rat. staining for choline acetyltransferase immunoreactivity in the brain was minimal before birth. adult levels of staini ... | 1991 | 1682850 |
| evidence that vasoactive intestinal peptide (vip) is an inhibitory transmitter in the ferret gastric corpus. | | 1991 | 1686329 |
| mechanism for the emetic side effect of xanthine bronchodilators. | the usefulness of xanthine bronchodilators in the treatment of asthma is often limited by the side effects of nausea and vomiting. we investigated the mechanism of emesis induced by xanthines, by examining the roles of phosphodiesterase (pde) inhibition and adenosine antagonism. theophylline, enprofylline, 8-phenyltheophylline and isobutylmethylxanthine (ibmx), as well as vehicle, were given to ferrets at doses ranging from 0.1 to 150 mg/kg i.p. the potencies of these compounds in producing emet ... | 1990 | 1689799 |
| peptide-containing nerve fibers in the circumvallate papillae. | the occurrence and distribution of an array of neuropeptides and dopamine-beta-hydroxylase in the circumvallate papillae of monkey, pig, cow, ferret, cat, rat and mouse was studied by immunocytochemistry. the animals were chosen to represent species with different diets. substance p/neurokinin a- and calcitonin gene-related peptide-containing fibers were numerous in the circumvallate papillae of all animals examined, with the highest frequency in monkey, pig, cow, rat and mouse; in ferret and ca ... | 1990 | 1691515 |
| effects of substance p and vasoactive intestinal polypeptide on contractile activity and epithelial transport in the ferret jejunum. | previous studies in the ferret demonstrated that vagal nerve stimulation induced an atropine-resistant water secretion. substance p and vasoactive intestinal polypeptide are possible mediators of this secretory response. the objectives of this study were to investigate the in vivo effects of substance p and vasoactive intestinal polypeptide on the jejunal musculature and epithelium. substance p caused an increase in jejunal motility, water secretion, and transmural potential difference. choliner ... | 1990 | 1692548 |
| auditory brainstem of the ferret: bilateral cochlear lesions in infancy do not affect the number of neurons projecting from the cochlear nucleus to the inferior colliculus. | unilateral cochlear removal in infancy produces a number of changes in the structure and physiology of the central auditory system. to test the role that interaural competition plays in this plasticity, ferrets were reared with bilateral cochlear removals from the fourth postnatal week; before the time of the normal onset of auditory function. the totality of the removals was confirmed using brainstem response audiometry and cochlear histology. following 3-month survival, the animals were inject ... | 1990 | 1694743 |
| positive inotropy contributes to the hemodynamic mechanism of action of flosequinan (bts 49465) in the intact dog. | flosequinan (bts 49465) is a putative, selective direct-acting balanced vasodilator currently undergoing evaluation for the treatment of congestive heart failure (chf) and hypertension. we examined the pharmacologic action of flosequinan and compared it to milrinone and nitroprusside (snp). in ferret papillary muscle, in vitro, flosequinan (1-100 microm) increased the rate of force development up to 116%. the effect was not blocked by nadolol (10 microm). flosequinan was less effective than milr ... | 1990 | 1694912 |
| [stimulation of mucous glands of the respiratory tract by neuropeptides: comparison of exogenous administration and endogenous liberation]. | exogenous substance p is a powerful stimulant of tracheal gland secretion but the contribution of endogenous neuropeptides to neurogenic gland secretion is unknown. using the ussing chamber technique, we measured the secretion of radiolabeled macromolecules from submucosal glands in the ferret. neurokinins caused gland secretion through a neurokinin-1 (nk-1) receptor. gland secretion caused by electric field stimulation of postganglionic nerve endings was not inhibited by a substance p antagonis ... | 1990 | 1695001 |
| modulation of ca2+ transients and contractile properties by beta-adrenoceptor stimulation in ferret ventricular muscles. | 1. the mechanism of modulation of ca2+ transients and contraction by beta-adrenoceptor stimulation was studied in ferret ventricular muscles using aequorin to measure intracellular ca2+. 2. peaks of tension and light transients were increased by isoprenaline (10(-9) - 5 x 10(-7) m) which also abbreviated their time courses. 3. time-to-peak tension was significantly shortened by 5 x 10(-9) m-isoprenaline and time-to-peak light was abbreviated by 10(-9) m-isoprenaline. 4. the time for the light to ... | 1990 | 1696985 |
| excitation-contraction coupling model to estimate the recirculating fraction of activator calcium in intact cardiac muscle. | potentiated contractions were evoked with rapid pace pause maneuver in 14 length-clamped ferret papillary muscles paced 12 times/min at 25 degrees c. at 1.25 mm [ca2+]o the average steady-state force was 2.94 +/- 1.08 g/mm2 and the potentiated contraction averaged 10.96 +/- 1.61 g/mm2. at 5.0 mm [ca2+]o the steady-state force increased to 6.18 +/- 1.23 g/mm2 and the potentiated contraction averaged 12.08 +/- 1.15 g/mm2. under the conditions of these experiments the potentiated contraction obtain ... | 1990 | 1697217 |
| use of dna restriction endonuclease digest and ribosomal rna gene probe patterns to fingerprint helicobacter pylori and helicobacter mustelae isolated from human and animal hosts. | variation amongst strains of helicobacter pylori and helicobacter mustelae was examined by dna restriction endonuclease digestion and rrna gene patterns generated using a non-radioactive probe. chromosomal dna was extracted from 30 cultures of h. pylori from human, rhesus monkey and pig gastric mucosa, and from three h. mustelae isolates from ferret gastric mucosa. dna fingerprinting with hae iii and hind iii showed h. mustelae was relatively homogeneous but revealed genomic heterogeneity within ... | 1990 | 1698260 |
| development of the lateral geniculate nucleus: interactions between retinal afferent, cytoarchitectonic, and glial cell process lamination in ferrets and tree shrews. | we have studied the relationship of retinal afferents, glial cell processes, and neuronal cytoarchitectonics in the lateral geniculate nucleus (lgn) of two species: tree shrews (tupaia belangeri) and ferrets (mustela putoris). both species are relatively immature at birth, allowing the development of these features to be studied in the perinatal period. retinal afferents, visualized by intraocular injection of a wheat germ agglutinin/horseradish peroxidase conjugate (wga-hrp), are apparently the ... | 1990 | 1698826 |
| the topographic relationship between shifting binocular maps in the developing dorsal lateral geniculate nucleus. | the major mammalian subcortical visual structures receive topographically ordered projections from both eyes. in the adult dorsal lateral geniculate nucleus (dlgn) each projection terminates in separate restricted regions of the nucleus. this pattern is different during development. initially in ferrets the projections from each eye to the dlgn overlap throughout this structure. although the projections do not occupy regions that are appropriate given the adult pattern, they are both retinotopic ... | 1990 | 1704850 |
| bleomycin chemotherapy for metastatic squamous cell carcinoma in a ferret. | bleomycin, an antitumor antibiotic, was effective in temporarily reducing the size of a metastatic squamous cell carcinoma in a ferret. the tumor had recurred after previous excision and had metastasized to the right submandibular lymph node. the ferret was treated without effect at a dosage of 10 u/m2, sc, once a week. the dosage was increased to 20 u/m2 once a week, and reduction of tumor size was observed. | 1991 | 1704878 |
| somatodendritic morphology of on- and off-cells in the rostral ventromedial medulla. | the rostral ventromedial medulla (rvm) contains two classes of physiologically defined neurons, on-cells and off-cells, that are implicated in nociceptive modulation. in a continuing effort to detail the neural circuitry that underlies the activity of these two distinct neuronal types, the somatodendritic morphology of on- and off-cells was studied in the cat, rat, and ferret. in lightly anesthetized animals, on-cells increased and off-cells decreased their discharge rate during a withdrawal ref ... | 1990 | 1706357 |
| emesis-related biochemical and histopathological changes induced by cisplatin in the ferret. | cisplatin is an effective antineoplastic agent that causes severe vomiting due to unknown mechanism. the ferret, an animal model useful in the determination of emetic activity, was used to clarify the emesis-related biochemical and histopathological changes that were induced by cisplatin. cisplatin (5 to 10 mg/kg) was administered intraperitoneally and a 7-10 mg/kg i.p. dose evoked dose-dependent emesis in the ferret. almost all cisplatin-vomiting episodes occurred within a 6 hour observation pe ... | 1990 | 1707101 |
| tachykinin receptors mediating airway macromolecular secretion. | three tachykinin receptor types, termed nk1, nk2, and nk3, can be distinguished by the relative potency of various peptides in eliciting tissue responses. airway macromolecular secretion is stimulated by the tachykinin substance p (sp). the purposes of this study were to determine the tachykinin receptor subtype responsible for this stimulation, and to examine the possible involvement of other neurotransmitters in mediating this effect. ferret tracheal explants maintained in organ culture were l ... | 1991 | 1708071 |
| sensory innervation of the mystacial pad fur of the ferret. | the guard and vellus hairs on the muzzles of many mammalian species possess a complex sensory innervation. the observation in the primate that the sources of the endings may be segregated by afferent type to separate terminal nerve branches prompted us to examine the innervation of the mystacial fur on the ferret muzzle. sections were prepared with reduced silver techniques and serially reconstructed for analysis. the types and orientations of sensory endings in the ferret are similar to those d ... | 1991 | 1708478 |
| effects of 8-bromo-cyclic gmp on contraction and on inotropic response of ferret cardiac muscle. | the effects of guanosine 3':5'-cyclic monophosphate (cgmp) on cardiac contraction are not established. using isolated electrically-stimulated ferret papillary muscle at 29 degrees c, 2.0 mm calcium we investigated the effects of 8-bromo-cgmp on (a) basal contraction for comparison with the effects of reduction in extracellular calcium or of reduction in resting muscle length; (b) contraction of preparations stimulated by isoprenaline, the dihydropyridine calcium agonist bay k8644 or post-extrasy ... | 1991 | 1709973 |
| the effects of calcitonin gene-related peptide on submucosal gland secretion and epithelial albumin transport in the ferret trachea in vitro. | 1. we have examined the effect of calcitonin gene-related peptide (cgrp) on basal mucus volume, lysozyme and albumin outputs from the ferret whole trachea in vitro, and on the outputs produced by methacholine and substance p (sp). we have also examined the effect of inhibiting neutral enkephalinase with thiorphan on the responses to cgrp. 2. cgrp (1-100 nm) produced small concentration-dependent increases in basal mucus volume, lysozyme and albumin outputs. these effect of cgrp were enhanced by ... | 1991 | 1710527 |
| characterisation of the urease from helicobacter pylori and comparison with the ureases from related spiral gastric bacteria. | the urease enzyme of helicobacter pylori was partially purified from whole cell extracts and found to have a molecular weight of 484 +/- 12 kda. ten monoclonal antibodies (mabs) were produced against four different epitopes of the native enzyme. these mabs also recognised the ureases of h. pylori-like organisms isolated from monkeys and pigs and the h. mustelae urease from ferrets. the urease enzymes of each of these organisms were found to be of the same molecular weight. the urease enzyme of h ... | 1991 | 1711875 |
| efficacy of a monoclonal antibody (moab 60.3) in reducing myocardial injury resulting from ischemia/reperfusion in the ferret. | the myocardial salvage efficacy of a monoclonal antibody (moab 60.3) directed at the cdw 18 membrane antigen complex essential for normal neutrophil function was evaluated in a ferret occlusion/reperfusion model. when infused i.v. over a 10-min interval beginning at the 45th minute of a 90-min occlusion at a fixed dose of 2 mg/kg, the antibody afforded 33 and 45% reductions in infarct size following reperfusion intervals of 6 and 24 h, respectively. administration of that same dose via the left ... | 1991 | 1714009 |
| presence of a cholinergic projection from ventral striatum to amygdala that is not immunoreactive for ngf receptor. | by combining the retrograde axonal transport of a fluorescent dye with nerve growth factor (ngf) receptor or choline acetyltransferase (chat) immunocytochemistry, we show that the cholinergic neurons that project most strongly to the basolateral nucleus of the amygdala in the ferret do not possess ngf receptor immunoreactivity in their soma and are situated in the ventral striatum, an area known to receive a massive reciprocal projection from the basolateral nucleus of the amygdala. | 1991 | 1715538 |
| is nerve growth factor required for the survival of retinal ganglion cells during development? | staining for nerve growth factor receptor was observed in the ferret's retinal ganglion cell layer, optic nerve and tract, and in the lateral geniculate nucleus and superficial layers of the superior colliculus in the prenatal period, but had disappeared by birth. thus the incidence of this transient staining does not correspond with the ganglion cell death that is known to occur in the ferret retina during the first postnatal week. | 1991 | 1715802 |
| factors released from endocardium of the ferret and pig modulate myocardial contraction. | 1. in isolated heart muscle preparations, selective removal of the endocardium results in a characteristic and unusual negative inotropic effect. possible mechanisms for this effect were investigated in this study. 2. in endocardium-intact preparations of ferret papillary muscle, 8-bromo-cyclic gmp, sodium nitroprusside, atrial natriuretic peptide (anp) and substance p each induced changes in contractile behaviour similar to selective endocardial removal, and each significantly elevated myocardi ... | 1991 | 1716674 |
| patchy intrinsic connections of the ferret primary auditory cortex. | small iontophoretic injections, of the leucoagglutinin extracted from phaseolus vulgaris (pha-l), were made at a depth of 600 microns, into the ferret primary auditory cortex (ai). the lectin anterogradely labelled the axons of pyramidal cells located in the upper layers. the axons had collaterals which terminated in 5-8 columns within ai. the columns were 0.25-0.8 mm in diameter and, based on their position, appeared to be in areas of cortex where the cells would have higher and lower as well a ... | 1991 | 1717047 |
| effects of new and potent methanesulfonanilide class iii antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle. | the effects of the new and potent methanesulfonanilide class iii antiarrhythmic agents (e-4031, uk-66,914, and uk-68,798) on myocardial refractoriness and contractility were compared to those of d-sotalol in ferret isometrically contracting right ventricular papillary muscle preparations. during 1 hz pacing at 37 degrees c, the four class iii agents elicited concentration-dependent increases in ventricular effective refractory period (erp), with a relative order of potency of uk-68,798 greater t ... | 1991 | 1720841 |
| alterations of intracellular calcium homeostasis and myocardial energetics in acute adriamycin-induced heart failure. | to elucidate the mechanism of acute contractile failure induced by adriamycin, the intracellular concentrations of free calcium ([ca2+]i) and energy-related phosphate compounds were determined in isolated ferret hearts. the time-averaged [ca2+]i was measured at 10 min resolution using fluorine nuclear magnetic resonance (nmr) spectroscopy and the nmr-sensitive ca2+ indicator 5f-bapta. [ca2+]i significantly increased from a control of 381 +/- 66 nm (mean +/- sem, n = 5) to 789 +/- 171 nm during 3 ... | 1991 | 1720844 |
| sprouting of cholinergic axons does not occur in the cerebral cortex after nucleus basalis lesions. | different doses of the excitotoxin quisqualate were used to make lesions in the caudal part of the ferret nucleus basalis, i.e. the part that projects to the visual cortex. the higher doses of the excitotoxin destroyed all nerve growth factor receptor-immunoreactive cells in the caudal nucleus basalis and gave rise to up to 75% loss of acetylcholinesterase-containing axons in the visual cortex. in sections stained for nissl substance there was generalized tissue damage around the injection sites ... | 1991 | 1722889 |
| a histomorphologic and immunohistochemical study of chordoma in twenty ferrets (mustela putorius furo). | the histomorphologic and immunohistochemical features of chordoma in 20 ferrets were evaluated. the mean age was 3.4 years, and, in the cases for which sex was known, females (n = 10) outnumbered males (n = 5) two to one. all 20 tumors occurred on the tip of the tail. nineteen of 20 tumors (95%) were composed of three tissue components, often arranged concentrically with lobules of physaliferous cells at the periphery, trabecular bone in the center, and cartilage in between. the bone often conta ... | 1991 | 1722924 |
| effects of aerosolized dexamethasone on acute subglottic injury. | aerosolized dexamethasone was used in a two-phase study to determine the possible effects on acute subglottic injury in the ferret animal model. in phase 1, equivalent subglottic injuries were made in 10 animals by using the brush technique, and the animals were divided into two groups. the treatment group received aerosolized dexamethasone at 2, 4, and 6 hours postinjury. all animals were examined 2, 4, 6, and 24 hours after the injury. the clinical condition of each animal was evaluated and th ... | 1992 | 1728893 |
| beta-carotene uptake and tissue distribution in ferrets (mustela putorius furo). | ferrets accumulate beta-carotene in liver and adipose tissue after chronic feeding. this study was designed to further evaluate the time course of uptake and depletion of beta-carotene in ferret serum and tissues. male ferrets (n = 15; 1000-1200 g) were given a single dose of beta-carotene (10 mg/kg body wt) with a meal. animals were killed at various time points over an 11-d period. blood and tissue samples were extracted and analyzed for beta-carotene by hplc. peak serum beta-carotene levels ( ... | 1992 | 1729459 |
| host species-specific antigenic variation of a mannosylated surface glycoprotein of pneumocystis carinii. | all pneumocystis carinii, irrespective of their host of origin, express an abundant mannosylated surface glycoprotein. while this molecule is commonly referred to as gp120, some variation in the size of this molecule has been noted. monoclonal antibodies produced to this molecule from ferret, mouse, rat, and human p. carinii made it possible to distinguish the glycoprotein from p. carinii of each host by immunoblot and indirect immunofluorescence assays. the glycoprotein varied in size (approxim ... | 1992 | 1730900 |
| immunohistochemical evidence for transient expression of fibronectin in the developing dorsal lateral geniculate nucleus of the ferret. | in recent years, the important role of the extracellular matrix in neural development has been increasingly recognized. in order to begin to examine what role might be played by the extracellular matrix in the developing dorsal lateral geniculate nucleus (dlgn), the present study used immunocytochemistry to assess the distribution of a recognized extracellular matrix molecule, fibronectin (fn), during postnatal development of the ferret dlgn. prior to the segregation of cell layers, no clear pat ... | 1992 | 1740545 |
| comparison of crossbridge dynamics between intact and skinned myocardium from ferret right ventricles. | this study compares the crossbridge kinetics of intact and skinned preparations from ferret cardiac muscles at 20 degrees c to determine whether skinning causes any alteration in the crossbridge response to an imposed length change. a papillary or trabecular muscle was isolated from the right ventricle, the muscle length adjusted to give the maximum twitch tension (lmax), and the preparation was subjected to ba2+ contracture. when steady tension developed, the length of the preparation was pertu ... | 1991 | 1742866 |
| early development of the retinal line of decussation in normal and albino ferrets. | this work describes the retinal origin of the crossed and uncrossed projections in newborn, 9-day-old and adult normally pigmented and albino ferrets. horseradish peroxidase (hrp) was injected unilaterally into the thalamic and midbrain visual centers of ferrets to label retinal ganglion cells retrogradely. in normally pigmented adults, the retinal line of decussation was sharp and passed through the area centralis. ganglion cells with uncrossed axons occupied the entire temporal retina. in albi ... | 1991 | 1748727 |
| cocaine alters heart rate dynamics in conscious ferrets. | this study was designed to test the hypothesis that cocaine intoxication induces distinctive alterations in sinus rhythm heart rate dynamics. time-series and spectral analysis techniques were used to examine the effects of lethal doses of cocaine on heart rate variability in conscious, restrained ferrets. in all animals (n = 5), cocaine administration resulted in a marked decrease in sinus rhythm heart rate variability prior to sudden death. heart rate variability (coefficient of variation of he ... | 1991 | 1750225 |
| abnormal cai2+ handling is the primary cause of mechanical alternans: study in ferret ventricular muscles. | we tested the hypothesis that mechanical alternans of the heart is due to alternations in intracellular calcium (cai2+) levels. eight papillary muscles were isolated from the right ventricles of male ferrets and were chemically loaded with aequorin to record cytoplasmic cai2+. to produce a steady-state mechanical alternans, the preparations were perfused with a physiological salt solution containing a low calcium concentration (0.25 mm), at 22 degrees c, and stimulated at 0.5-1.0 hz in the prese ... | 1991 | 1750531 |
| vagal influences on gastric acid secretion in response to gastric distension in the ferret. | the role of the vagus nerve in the stimulation of gastric acid secretion was investigated by comparing the acid output in response to gastric distension during augmented secretion mediated by electrical vagal stimulation and pentagastrin. under control conditions distension increased acid output from 29.8 +/- 3 mumol/10 min to 59.9 +/- 5.5 mumol/10 min (p less than 0.0001). bilateral cervical vagotomy significantly reduced both basal acid secretion and the response to distension although the inc ... | 1991 | 1753062 |
| the isolated, buffer-perfused ferret heart: a new model for the study of cardiac physiology and metabolism. | the isolated, buffer-perfused ferret heart is a new model for the study of cardiac physiology and metabolism. compared to the more commonly used isolated heart preparation, the rat heart, the ferret has a lower rate-pressure product due to lower heart rate, a remarkably low coronary flow and almost complete oxygen extraction. the ferret heart remains in stable haemodynamic and metabolic conditions for a longer period of time than the rat heart. atp contents of the two species are similar, but cr ... | 1991 | 1753696 |
| kainic acid lesions of the superior olivary complex: a horseradish peroxidase study of surviving brain-stem projections. | lesions of the superior olivary complex of the adult ferret were made by pressure injection of kainic acid (5 nm/microliters in locke's solution) through a glass micropipette inserted into the lower brain-stem. small injections of kainic acid (1.5 microliters) produced a localized loss of nerve cells in the superior olivary complex in the vicinity of the pipette tip without apparent damage to fibers of passage in the trapezoid body. the extent of neural damage was determined by the absence of ce ... | 1991 | 1762453 |
| dendritic morphology and development in the ferret lateral superior olivary nucleus. | the dendritic morphology of cells in the lateral superior olivary nucleus was studied with the golgi method in adult and postnatal ferrets. the lateral superior olivary nucleus in the adult ferret is a convoluted structure with an m-shape in frontal sections. the major cell type appears to have disk-shaped dendritic trees. most dendritic trees appear to be approximately orthogonal to the curved medial-lateral axis of the nucleus. depending on their position in the limb and on the plane of sectio ... | 1991 | 1765583 |
| locally and reflexly mediated effects of cholecystokinin-octapeptide on the ferret stomach. | this study was undertaken to investigate the site of origin of vagal reflexes which cholecystokinin (cck) activates to cause reflex inhibition of gastric motility. in the anaesthetized ferret, close intraarterial injections of cck-8 (100 pmol) caused a short latency increase in duodenal contractile activity; antral motor responses to cck were variable, often comprising excitation followed by inhibition. the corpus, in contrast, consistently showed a decrease in pressure which lasted 2-3 min befo ... | 1991 | 1765619 |
| possible involvement of a chloride conductance in the transient outward current of whole-cell voltage-clamped ferret ventricular myocytes. | the transient outward current was studied, using the whole-cell patch-clamp technique, in isolated ventricular cells from the ferret heart. in the presence of 4-aminopyridine and cadmium chloride which respectively blocked the ca-insensitive and the ca-dependent outward currents, a residual transient outward current was observed in about 30% of the cells tested. this current was suppressed in external hypochloride solution, completely inhibited by sits (3 mm) and reversed at the equilibrium pote ... | 1991 | 1775377 |
| spiral organisms: what are they? a microbiologic introduction to helicobacter pylori. | the stomach provides a hostile environment to most microorganisms owing to the antibacterial effect of gastric acidity. however, over the period of mammalian evolution a highly specialized group of bacteria has evolved to inhabit the gastric mucosa. the common features of these bacteria that allow survival in the stomach and colonization of their natural ecologic niche, mucus, are a specialized form of motility, microaerophilism, and very high activity of the enzyme urease. other important adapt ... | 1991 | 1775930 |
| segmental barrier properties of the pulmonary microvascular bed. | we determined liquid flux across single pulmonary microvessels of dog, ferret, and rat by our split-drop technique (j. appl. physiol. 64: 2562-2567, 1988). data are reported from 58 lungs excised under halothane or pentobarbital sodium anesthesia and then blood perfused. we stopped blood flow at known vascular pressures and then micropunctured microvessels to inject oil, which we split with albumin solution. from measurements of vessel diameter and split oil drop length, we calculated jv, the li ... | 1991 | 1778906 |
| effects of transient changes in membrane potential on twitch force in ferret papillary muscle. possible effects on na-ca exchange. | | 1991 | 1785868 |
| kinetic models of na-ca exchange in ferret red blood cells. interaction of intracellular na, extracellular ca, cd, and mn. | the kinetic equation that best describes the intracellular na dependence of ca influx into ferret red cells is sequential; whether this implies that there is a conformation of the protein that has both na and ca ions bound remains to be determined. cd and mn substitute very well for ca on the exchanger in ferret red cells; this suggests that the ca-binding site does not contain an important thiol and that the one of the na steps may be rate limiting. | 1991 | 1785889 |
| serotoninergic innervation of the ferret cerebral cortex. i. adult pattern. | we have investigated the serotoninergic innervation of the adult ferret cerebral cortex with immunohistochemical techniques. distribution pattern of serotoninergic fibers in the ferret neocortex is characterized by a decrease in the density of fibers as one moves from the pial surface towards the white matter. throughout the entire cerebral cortex, the serotoninergic fibers are very dense within the supragranular layers, especially within layer 1. in contrast, granular and infragranular layers e ... | 1991 | 1787182 |
| serotoninergic innervation of the ferret cerebral cortex. ii. postnatal development. | we have investigated the serotoninergic innervation of the ferret cortex from the day of birth to adulthood with immunohistochemical techniques. due to the premature birth of ferrets, this period spans the entire generation of cells located within the upper cortical layers and their subsequent migration to their final positions. already at birth, serotoninergic fibers innervate the developing cortex. this innervation is most dense within the marginal zone, the subplate region, and the lower port ... | 1991 | 1787183 |
| vascular abnormalities in experimental and human lymphatic filariasis. | whereas clinical descriptions of grotesque lymphedema and standard light microscopy in human filariasis have elucidated the natural progression of this disease, the link between the nematode and vascular abnormalities including elephantiasis remains poorly understood. accordingly, we examined the nature and distribution of lymphatic and blood vascular derangements in a variety of tissues and organs from 37 ferrets acutely and chronically infected with brugia malayi and in 15 patients with wucher ... | 1991 | 1791728 |
| quantitative light and scanning electron microscopy of ferret sperm. | sperm were obtained via electroejaculation from domestic ferret, (mustela putorius furo), siberian ferret (m. eversmanni), black-footed ferret (m. nigripes), and a hybrid between siberian and domestic, called the fitch ferret (m. sp.). comparisons of sperm were made by four different microscopy techniques to determine whether differences exist among species. first, nomarski differential interference microscopy could be used to distinguish domestic ferret sperm from the others on the basis of the ... | 1991 | 1793602 |
| distribution of choline acetyltransferase immunoreactive axons and terminals in the rat and ferret brainstem. | a survey was made of the density of the cholinergic innervation of different parts of the brainstem of the rat and ferret. sections of rat and ferret brainstems were stained for choline acetyltransferase (chat) immunoreactivity by using a sensitive immunocytochemical method. adjacent sections were stained for acetylcholinesterase activity or nissl substance. the density of the distribution of fine calibre, varicose chat-positive axons, assumed to represent cholinergic terminals, was categorised ... | 1991 | 1797870 |
| ultrasonography of the adrenal gland. | a current review of ultrasonographic adrenal imaging is presented with emphasis on the clinical and problematic aspects of adrenal disease in the dog. examples are presented to illustrate the usefulness of ultrasonography in distinguishing between canine pituitary- and adrenal-dependent hyperadrenocorticism. adrenal imaging in the cat and ferret are discussed briefly. when coordination of sonographic findings with clinical and biochemical results is implemented properly, ultrasonography becomes ... | 1991 | 1802272 |
| the effect of hydrogen peroxide on smooth muscle tone, mucus secretion and epithelial albumin transport of the ferret trachea in vitro. | the effect of hydrogen peroxide (h2o2) was examined on baseline and on methacholine- and phenylephrine-stimulated smooth muscle tone, mucus volume and lysozyme outputs, and epithelial albumin transport of the ferret whole trachea in vitro. h2o2 (10 microm-10 mm) had no significant effect on tracheal smooth muscle tone but produced concentration-dependent increases in mucus volume, lysozyme and albumin outputs. the potential difference (p.d.) across the trachea was not changed by h2o2. exposure o ... | 1991 | 1804498 |
| endothelin-1 inhibits pre-stimulated tracheal submucosal gland secretion and epithelial albumin transport. | 1. endothelin-1 potently contracts smooth muscle, including that in the airways. however, its effect on airway mucosal function has not so far been studied. 2. we have used the ferret whole trachea in vitro to examine the effect of endothelin-1 on tracheal smooth muscle tone, transepithelial potential difference (p.d.), submucosal gland secretion (including lysozyme secretion from serous cells) and active epithelial albumin transport. in addition we have examined the effects of endothelin on sub ... | 1991 | 1810592 |
| antiemetic effects of ym060, a potent and selective serotonin (5ht)3-receptor antagonist, in ferrets and dogs. | ym060, (r)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1h-benzimidazole hydrochloride, is a new serotonin (5ht)3-receptor antagonist. we examined the effects of ym060 on chemotherapeutic agent-, apomorphine- and copper sulfate-induced emesis. intravenous ym060 potently prevented cisplatin (10 mg/kg, i.v.)-induced emesis with ed50 values of 0.06 (0.05-0.07) micrograms/kg, i.v. in ferrets. based on the ed50 values, ym060 was 300, 20 and 100 times more potent than ondansetron, granisetron a ... | 1991 | 1813664 |
| immunologic comparisons of pneumocystis carinii strains obtained from rats, ferrets, and mice using convalescent sera from the same sources. | pneumocystis carinii (pc) infections were developed in animals immunosuppressed by dexamethasone treatment either from activation of latent infection (ferret) or trans-tracheal inoculation of pc obtained from infected lungs of the homologous species (rat, mouse). convalescent antisera were obtained by stopping dexamethasone treatment after 2-4 wk and allowing 5-8 wk for recovery. parasites from infected lungs were purified by differential filtration, solubilized in loading buffer, subjected to s ... | 1991 | 1818152 |
| molecular cloning and characterization of ferret pneumocystis carinii gp120. | | 1991 | 1818195 |
| comparison of pulsed field gel electrophoresis karyotypes of pneumocystis carinii derived from rat lung, cell culture, and ferret lung. | pulsed field gel electrophoretic karyotypes of pneumocystis carinii derived from three sources were compared: immunosuppressed virus-free rats transtracheally inoculated with pneumocystis-infected rat lung; wi-38 cell/cytodex bead cell cultures inoculated with the same material; and immunosuppressed ferrets which reactivated latent pneumocystis pneumonia. karyotypes of dna from pneumocystis trophozoites or cysts from rat lung, and trophozoites from cell culture were identical. in contrast, ferre ... | 1991 | 1818212 |
| sodium-dependent magnesium uptake by ferret red cells. | 1. magnesium uptake can be measured in ferret red cells incubated in media containing more than 1 mm-magnesium. uptake is substantially increased if the sodium concentration in the medium is reduced. 2. magnesium uptake is half-maximally activated by 0.37 mm-external magnesium when the external sodium concentration is 5 mm. increasing the external sodium concentration increases the magnesium concentration needed to activate the system. 3. magnesium uptake is increased by reducing the external so ... | 1991 | 1822527 |
| modulation of calcium-activation in control and pressure--overload hypertrophied ferret hearts: effect of dpi 201-106 on myofilament calcium responsiveness. | we examined the relationship between free ca2+ and developed force in chemically skinned fibers from control and pressure-overload hypertrophied (poh) hearts of ferrets in the absence and presence of dpi 201-106 (4-([3-(4-diphenyl-methyl-l-piperazinyl)-2-hydroxypropoxy]-1h-indole-2- carbonitrile), a positive inotropic and negative lusitropic agent. force production in both control and hypertrophied fibers increased with ca2+ concentration ([ca2+]) over a range from 10(-7) m to 10(-4) m, and did ... | 1991 | 1828088 |
| intracellular na activity measurements in the control and hypertrophied heart of the ferret: an ion-sensitive micro-electrode study. | because of the role of intracellular na on cardiac contractility and of the depressed isometric contractile response of the hypertrophied myocardium, the effects of pressure overload on the intracellular na activity (aina) have been investigated in papillary muscles isolated from the ferret right ventricle. in animals subjected to pulmonary artery clipped for 1-2 months, right ventricle-to-body weight ratio was increased by about 39% in comparison with the control group. aina was measured in qui ... | 1991 | 1831556 |
| 5-ht3 receptor agonism may be responsible for the emetic effects of zacopride in the ferret. | the racemic 5-ht3 receptor antagonist, zacopride (10-100 micrograms kg-1, i.m.) evoked an emetic response in ferrets. this property appeared to reside totally in the s-enantiomer which also produced emesis over the same dose range. this emesis could be prevented by pretreatment with ondansetron (1 mg kg-1, i.m.) or by r-zacopride (100 micrograms kg-1, i.m.). in urethane-anaesthetized ferrets, s-zacopride (0.3 micrograms kg-1, i.v.) evoked a profound bezold-jarisch reflex which was blocked by bot ... | 1991 | 1831684 |
| inoculation of ferrets with ten third-stage larvae of dracunculus insignis. | infection with dracunculus insignis was established in 7 of 10 ferrets experimentally inoculated intraperitoneally with 10 third-stage larvae (l3's). worm recovery and infection rate were comparable to animals inoculated with 50 l3's. this study demonstrates that once infective larvae traverse the gut and pass into the peritoneal cavity, very few larvae are required to establish infection. | 1991 | 1833521 |
| gastric colonization of the ferret with helicobacter species: natural and experimental infections. | helicobacter mustelae, isolated from the stomachs of adult ferrets, appears to have a world-wide distribution. ferrets are colonized with h. mustelae at a young age, usually 5-6 weeks; in our experience 100% of adult ferrets are colonized in both the antrum and the fundus. gastric infection correlates with elevation of serum igg antibodies to h. mustelae. in the oxyntic mucosa the presence of superficial gastritis coincides closely with the presence of h. mustelae. in the distal antrum the organ ... | 1991 | 1833810 |
| antiemetic activity of the new 5-ht3 antagonist dau 6215 in animal models of cancer chemotherapy and radiation. | the antiemetic activity of dau 6215, a novel antagonist of 5-ht3 receptors, was investigated in animal models of cytotoxic treatment-evoked emesis and compared with the antiemetic activity of ondansetron and metoclopramide. in dogs, vomiting was induced by i.v. cisplatin; in ferrets, the emetic response was elicited by i.v. doxorubicin or x-ray exposure. pretreatment with 0.1-1 mg/kg dau 6215 given i.v. or p.o. prevented the vomiting response to the different emetic agents. in the dog, the antie ... | 1991 | 1834359 |
| altered calcium handling in left ventricular pressure-overload hypertrophy as detected with aequorin in the isolated, perfused ferret heart. | the purpose of this study was to test the hypothesis that systolic and diastolic dysfunction in left ventricular pressure-overload hypertrophy is caused by abnormal intracellular calcium handling. experiments were performed with intact, buffer-perfused, isovolumic ferret hearts (n = 9 hypertrophied, n = 9 control) that were loaded with the bioluminescent indicator aequorin to monitor changes in cytoplasmic calcium. in each experiment, left ventricular pressure and intracellular calcium transient ... | 1991 | 1835431 |
| [ondansetron: a specific 5-ht3 serotonin receptor inhibitor, a new antiemetic in oncology]. | serotonin (5-hydroxytryptamine) seems to play a dominant role in triggering vomiting induced by cytotoxic agents through the stimulation of 5-ht3 receptors. they have been observed in the gi tract as well as in the brain (area postrema). ondansetron is a specific antagonist of 5-ht3 serotonin receptors. its anti-emetic activity is very powerful in the ferret. the availability of an injectable or oral form of this product allows the overall treatment of acute and delayed emesis and its administra ... | 1991 | 1838490 |
| bay u3405, a potent and selective thromboxane a2 receptor antagonist on airway smooth muscle in vitro. | 1. bay u3405 (3(r)-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4- tetrahydro-9h-carbazole-9-propanoic acid) has been evaluated on airway smooth muscle, from a number of species including man, for its thromboxane a2 (txa2) antagonist activity. 2. bay u3405 was a potent, and competitive, antagonist of the txa2-mimetic u46619-induced contractions of human, guinea-pig, rat and ferret airway smooth muscle with pa2 values between 8.0 and 8.9 and with no inherent contractile activity (10(-9)-10(-4) m). 3 ... | 1991 | 1839139 |
| ca(2+)-independent change in phosphorylation of the myosin light chain during relaxation of ferret aorta by vasodilators. | 1. the effects of the vasodilators atrial natriuretic peptide (anp) and forskolin were determined on isometric force, intracellular ionized ca2+ concentration ([ca2+]i) as indicated by aequorin, and myosin light chain (mlc) phosphorylation in ferret aorta. 2. atrial natriuretic peptide (10(-7) m) inhibited intrinsic tone with an associated significant decrease in [ca2+]i. anp also inhibited the contraction induced by kcl with a significant decrease in [ca2+]i. mlc phosphorylation induced by kcl ... | 1991 | 1839559 |