| a comparison of thermoregulatory responses in the japanese macaque (macca fuscata) and the crab-eating macaque (macaca irus) during cold exposure. | thermoregulatory responses in four male adult japanese macaques and four male adult crab-eating macaques, weighing 6-12 kg and 6.2-8 kg, respectively, were compared at ambient temperatures (ta) ranging from 5 degrees c to 25 degrees c. the average values +/- s.e. for some physiological measurements made at ta of 25 degrees c in the japanese macaque and the crab-eating macaque, respectively, were as follows: resting metabolic rate; 47.6 +/- 5.0 and 42.5 +/- 1.7 w/m2; tissue conductance; 11.9 +/- ... | 1975 | 1152303 |
| purification of zymogen granules from monkey parotid glands. | a method giving highly purified zymogen granules from macaca irus and cercopithecus aethiops parotid glands in reported. a 0.3 m sucrose medium for homogenization was supplemented with 10 mm tris/hcl, ph 7.3, and 0.1 mm lauric acid to stabilize the fragile monkey zymogen granules. nuclei and cell debris were sedimented at 150 times g. a "crude" zymogen granule fraction was trapped in the 1.0 m sucrose layer of a discontinuous sucrose gradient at 1000 times g. equilibrium centrifugation in a cont ... | 1975 | 1155105 |
| in vitro production of sulphated mucosubstances by the labial and palatine glands of the monkey macaca irus. | | 1975 | 1054577 |
| effects of triamcinolone acetonide on experimental oral candidiasis in monkeys. | thirteen adult monkeys (macaca irus) were infected with candida albicans by inoculating the microorganisms under an acrylic plate covering the palatal mucosa. six of the monkeys were treated with the steroid triamcinolone acetonide intramuscularly for 2 weeks before and 2 weeks after inoculation. the palatal mucosa was studied clinically and histologically at weekly or biweekly intervals for up to 5 months after inoculation. the cellular immune response was studied using the direct leukocyte mig ... | 1975 | 1056095 |
| arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets. | fibrous proteins were measured in five arterial beds in adult cynomolgus monkeys after administration of atherogenic and regression regimens. atherosclerosis was induced by feeding the monkeys a hypercholesterolemic diet containing 1.2% cholesterol for 17 months. a low-fat, cholesterol-free regression diet was then given for 60 days, 200 days, and 20 months. in atherosclerosis, collagen concentration (mg/g dry weight) and collagen content (mg/cm length of artery) both increased. at 200 days of r ... | 1975 | 1116235 |
| [new aspects of surgical treatment of glaucoma. comparison of viscoelastic substances in chamber angle surgery]. | the development of new viscoelastic substances opens up new perspectives for chamber angle surgery under direct view. the success of "cyclodialysis ab interno" treating children with glaucoma is often reduced by scar formation of the cleft. therefore four different viscoelastic substances were instilled during an animal experimental study into the cleft and compared in their effect. we used hyaluronic acid with different molecular weight (healon and healon gv) and cross-linked forms of hyalurona ... | 1992 | 1303705 |
| enrofloxacin treatment of long-tailed macaques with acute bacillary dysentery due to multiresistant shigella flexneri iv. | thirty-four cases of acute bacillary dysentery occurred within 90 days among macaques housed at the california regional primate research center. cases were identified by depression, diarrhea with blood and leukocytic exudate, and/or leukocytosis with a left shift. antimicrobial susceptibility testing of enteric isolates and plasmid profile analyses established an etiologic diagnosis of multiple antibiotic resistant shigella flexneri iv infection. when standard therapies were invalidated by high ... | 1992 | 1320152 |
| receptor-mediated and absorptive endocytosis by male germ cells of different mammalian species. | the routes for adsorptive and receptor-mediated endocytosis were studied in vivo after microinjection of tracers into the lumen of the seminiferous tubules, and in vitro in isolated germ cells of different mammals. cationic ferritin was located on the plasma membrane, in vesicles, in tubules, in multivesicular bodies and in lysosome-like granules of mouse spermatocytes. in these cells the number of multivesicular bodies varied during spermatogenesis. spermatids and to a lesser extent residual bo ... | 1992 | 1321002 |
| induction of various cytochromes cyp2b, cyp2c and cyp3a by phenobarbitone in non-human primates. | male and female patas (erythrocebus patas) and cynomolgus (macaca fascicularis) monkeys were treated with phenobarbitone (pb) and examined for the induction of various cytochrome p450 (p450)-mediated drug metabolizing enzymes. hydroxylation of testosterone at the 6 beta, 2 beta, and 15 beta positions, metabolites normally associated with cyp3a p450s increased 2- to 5-fold in pb-treated animals. induction of this p450 family was confirmed by the use of polyclonal antisera directed against the hum ... | 1992 | 1306117 |
| neurotoxic effects of the anti-varicella zoster virus agent 2'-valeryl-6-methoxypurine arabinoside in monkeys and rats dosed orally for 90 days. | the 2'-valerate ester of 6-methoxypurine arabinoside (170u88), a nucleoside analog with anti-varicella zoster virus (vzv) activity, was given to monkeys and rats. in subchronic preclinical toxicity studies, dosing was by gavage to monkeys (distilled water vehicle) and rats (0.5% methylcellulose vehicle) for 90 days. groups of 5 male and 5 female monkeys (macaca fascicularis) were given 170u88 at 0, 25, 50, or 100 mg/kg/day. the daily dose was given in two equal portions with 6 hr between doses. ... | 1992 | 1318240 |
| effects of penfluridol and other drugs on apomorphine-induced stereotyped behavior in monkeys. | the effects of some drugs on apomorphine-induced stereotyped behavior were studied in male cynomolgus monkeys. apomorphine produced the dose-dependent stereotyped behavior characterized mainly by continuous licking and biting, and repetitive movements of the hands, head and body in the monkeys. penfluridol as well as haloperidol showed a clear antagonistic effect on the apomorphine-induced stereotyped behavior, while chlorpromazine was less antagonistic than haloperidol. the antagonistic effect ... | 1975 | 1171014 |
| the in vivo metabolism of cortisol and corticosterone by the macaque monkey (macaca fascicularis). | (4-14c) cortisol was administered intramuscularly to one adult female macaque monkey, mf3 (macaca fascicularis). to adult female macaque monkey, mf4, (4-14c)corticosterone was administered intramuscularly. urine samples were collected and the metabolites excreted identified using gas chromatography, radio-gas chromatography and gas chromatography-mass spectrometry. the principal metabolites of cortisol were identified as glucuronide conjugates of 11-oxygenated-17-oxosteroids. the excretion of te ... | 1975 | 1172896 |
| [11c]ro 15-4513, a ligand for visualization of benzodiazepine receptor binding. preparation, autoradiography and positron emission tomography. | ro 15-4513, a partial inverse agonist at the benzodiazepine (bz) receptor site was labelled with 11c and used for in vitro autoradiography on human post mortem brain sections and for positron emission tomography (pet) on cynomolgus monkeys. the total radiochemical yield of [11c]ro 15-4513 was 30-40% with an overall synthesis time of 40 min. the specific radioactivity was about 1000 ci/mmol at end of synthesis. in vitro autoradiography showed that [11c]ro 15-4513 bound specifically predominantly ... | 1992 | 1329130 |
| hepatitis b core antigen in the immunosuppressed chimpanzee. | two chimpanzees with low levels of anti-hbs developed increased antibody titres but showed no antigenemia after i.v. administration of 10 ml infective chimpanzee serum. treatment of a chimpanzee (also possessing anti-hbs) i.m. with cyclophosphamide plus prednisolone for 3 weeks starting 2 days before the challenge with infective serum resulted in detectable circulating hbsag by day 67. by day 95, the hbsag concentration had increased to 17 times a human ag reference plasma and low titres of anti ... | 1975 | 1204961 |
| pharmacokinetic studies of cp-74,667, a new quinolone, in laboratory animals. | the pharmacokinetics of cp-74,667 (7-(8'-methyl-3',8'-diazabicyclo[3.2.1]oct-3'-yl)-1-cyclopropyl-6- fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid) were studied following oral or parenteral administration in mice, rats, rabbits, dogs, and cynomolgus monkeys. the mean peak levels of cp-74,667 in serum following a single oral dose of 20 mg/kg of body weight were similar in all species, with a range of 3.7 micrograms/ml in mice to 5.6 micrograms/ml in dogs. in contrast, elimination half-lives ... | 1992 | 1329625 |
| generation of macaque b lymphoblastoid cell lines with simian epstein-barr-like viruses: transformation procedure, characterization of the cell lines and occurrence of simian foamy virus. | two simian epstein-barr-like viruses, a rhesus epstein-barr virus and herpesvirus papio, were used to transform b cells from rhesus or cynomolgus macaques. the resulting cell lines exhibited predominantly a b lymphocyte phenotype and expressed epstein-barr virus antigens. the majority of b lymphoblastoid cell lines from macaques, which were seropositive for simian foamy virus, developed giant cells in culture. the cytopathic agent was identified as a foamy virus and was transmissible to human em ... | 1992 | 1331148 |
| [virus persistence in hepatitis a in monkeys]. | a long-term complex observation of 16 cynomolgus monkeys (macaca fascicularis) and 8 african green monkeys (cercopithecus aethiops) with spontaneous and experimental hepatitis a revealed two forms of the illness: acute and chronic. some monkeys developed undulating chronic course of the disease consisting of 2-6 waves. others developed relapses (1 to 3) which occurred within 2-4 or 6-11.5 months of the infection. the morphological changes in the liver persisted for 7-28 months. alaninaminotransf ... | 1992 | 1332264 |
| toxicological studies on azapropazone. | the toxicity of azapropazone, a non-steroidal anti-inflammatory analgesic compound was studied in mice, rats, hamsters, guinea pigs, rabbits, cats, mongrel and beagle dogs, domestic pigs, rhesus monkeys, cynomolgus monkeys and baboons in experiments which ranged from acute, single-dose studies up to treatment periods of 1 year. the beagle dog was found to be especially sensitive to gastro-intestinal ulceration from azapropazone and this contrasted with the marked lack of gastro-intestinal hazard ... | 1976 | 1261299 |
| biomarkers for individual susceptibility to carcinogenic agents: excretion and carcinogenic risk of benzo[a]pyrene metabolites. | in rats exposed to a single intraperitoneal dose of 200 mg/kg of the environmental carcinogen benzo[a]pyrene (bp) in sunflower oil, significant individual variations in excretion of the bp activation (bp-7,8-diol) and deactivation (3-oh-bp) derivatives were found. most rats developed peritoneal sarcomas. only the levels of bp-7,8-diol excreted in the urine correlated directly with the latency of tumor formation. after a similar exposure to a dose of 100 mg/kg bp, macaca fascicularis monkeys excr ... | 1992 | 1336725 |
| the effects of prostaglandin e1 on the ciliary epithelium and the drainage angle of cynomolgus monkeys: a light- and electron-microscopic study. | | 1976 | 1269539 |
| an outbreak of melioidosis in imported primates in britain. | an outbreak of melioidosis, a bacterial infection caused by pseudomonas pseudomallei, was identified in a batch of feral cynomolgus monkeys (macaca fascicularis) imported to britain from the philippines. thirteen confirmed or possible cases occurred among a batch of 50 animals. subsequent investigations revealed that the infection was uncommon among imported primates from a variety of sources, although three other cases were identified in monkeys imported from indonesia. the majority of the affe ... | 1992 | 1279882 |
| effect of naloxone administration upon the diurnal concentrations of oxytocin in the cerebrospinal fluid of rhesus and cynomolgus monkeys. | a diurnal pattern in oxytocin concentrations is present in cerebrospinal fluid (csf) removed from the spinal subarachnoid space of monkeys, with elevated levels occurring in the early light hours. in order to investigate the possible role of endogenous opioid peptides in the generation of this oxytocin rhythm, we administered naloxone (0.4 mg/kg/h x 48 h) to rhesus and cynomolgus monkeys and examined the effects on the diurnal pattern of oxytocin in csf collected from the lumbar subarachnoid spi ... | 1992 | 1339135 |
| in vivo effects of interleukin-6 on thrombopoiesis in healthy and irradiated primates. | we have studied the in vivo effects of recombinant human interleukin-6 (rhil-6) on hematopoiesis in eight healthy and nine irradiated cynomolgus monkeys. of the healthy animals, three received rhil-6 alone (10 micrograms/kg/d, subcutaneously [sc]), one received rhil-6 in combination with rhil-3 (10 micrograms/kg/d, sc), one received rhil-6 in combination with recombinant cynomolgus granulocyte-macrophage colony-stimulating factor (rcgm-csf; 10 micrograms/kg/d, sc), two received rhil-6 in combina ... | 1992 | 1280477 |
| bilateral innervation of the musculus levator palpebrae superioris by single motoneurons in the monkey. | the location of motoneurons innervating the musculus levator palpebrae superioris (lps) was studied in the monkey (macaca irus) by using fast blue (fb) and propidium iodide (pi) as retrograde neuronal tracers. in each monkey, fb was injected into the lps of one eye and pi into the lps of the other eye. neuronal cell bodies labeled with fb and/or pi were seen intermixed bilaterally through the entire rostrocaudal extent of the central caudal nucleus. while single-labeled (70%) cell bodies predomi ... | 1992 | 1282224 |
| [opportunistic malignant lymphomas in siv infected primates--a model for epstein-barr virus associated lymphomas in aids]. | in a series of 33 cynomolgus monkeys (macaca fascicularis) experimentally infected with simian immunodeficiency virus (siv), strain smm3, 13 animals developed malignant non-hodgkin lymphomas. these lymphomas presented with unusual primary manifestations like in the orbita, testes, and brain. the morphological features and immunophenotyping identified the tumors as high malignant b-cell lymphomas. in all tumors as well as in tumor-derived cell lines a cynomolgus b-lymphotropic herpes virus (cblv) ... | 1992 | 1283256 |
| mouse/human chimeric anti-hiv-1 gp120 antibody to the principal neutralizing determinant: tolerability and pharmacokinetics in cynomolgus monkeys, macaca fascicularis. | in preparing for testing a pharmaceutical grade preparation of chimeric (mouse/human) antibody cgp 47,439 in hiv-1 infected individuals, it was administered to macaca fascicularis (cynomolgus) monkeys to study tolerability, immunogenicity and pharmacokinetics. four groups of monkeys, three males and three females per group, received respectively four infusions of 0, 1.43, 4.3, and 14.3 mg of cgp 47,439/kg body weight at one-week intervals. the chimeric antibody induced no fever, was tolerated we ... | 1992 | 1283953 |
| use of bovine osteogenic protein to promote rapid osseointegration of endosseous dental implants. | an enriched bovine osteogenic protein preparation in combination with bone collagen matrix (osteogenic protein device) was used to effect new bone growth in extraction sites in the presence or absence of titanium dental implants. incisor and canine teeth were extracted from each of three cynomolgus monkeys, and implants were inserted directly into the sockets without surgical site preparation. the osteogenic protein device induced new bone formation in close apposition to the titanium implants i ... | 1992 | 1289254 |
| stereo architecture of the connective tissue cores of the lingual papillae in the treeshrew (tupaia glis). | the stereo architecture of the lingual connective tissue cores (ctc) in the treeshrew (tupaia glis) (which has the primitive characteristics of primates) was observed by scanning electron microscopy, and compared to that of other animal orders. the tongue of the treeshrew has three vallate papillae which are situated in the posterior part of the tongue, while some macaques have several vallate papillae. among numerous filiform papillae, fungiform papillae are sporadically distributed. a filiform ... | 1992 | 1292368 |
| multiple antigen challenge produces pulmonary eosinophilia but not pulmonary hyperresponsiveness in actively sensitized guinea pigs. | exposure of actively sensitized boosted guinea pigs to aerosolized antigen, 3 times on alternate days, produced pulmonary eosinophilia but not pulmonary hyperresponsiveness to methacholine cl measured 3 days after the last antigen challenge. these data suggest that the presence of large numbers of eosinophils in the airways and tissues of the lungs is not sufficient to produce nonspecific pulmonary hyperresponsiveness. these data also suggest that actively sensitized and boosted guinea pigs resp ... | 1992 | 1295363 |
| activation of b virus (herpesvirus simiae) in chronically immunosuppressed cynomolgus monkeys. | three of 14 cynomolgus monkeys given the highest dose of an immunosuppressive drug in a 6-month toxicology study developed b virus (herpesvirus simiae) oral lesions after 3 months of dosing. this necessitated early removal of all high-dose monkeys from the study due to concerns related to b virus. the incidence and severity of parasitic (oesphagostomum sp.) lesions of the large intestine were also increased in high-dose animals. both b virus and oesophagostomum are enzootic in macaques, and the ... | 1992 | 1351111 |
| [tyrosine hydroxylase-immunohistochemical study in the midbrain of experimental mptp parkinsonism]. | we have performed tyrosine hydroxylase (th)-immunohistochemical study in the midbrain of experimental mptp parkinsonism. eight female adult crab-eating monkeys (macaca fascicularis) were subjected to the experiment and divided into four groups. in the acute experimental parkinsonism (group a), a daily dose of 1.3 mg/kg mptp was given intravenously for 7 days. monkeys in the subacute group b were injected every other day a dose of 1.0 mg/kg mptp intravenously for 7-14 days. chronic experimental p ... | 1992 | 1351802 |
| the evaluation of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1h-imidazol-2-yl)amino] benzoate dimethanesulfonate (fut-187) by oral administration in cynomolgus monkeys in a 13 week subacute toxicity study. | to assess the subacute toxicity of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1h-imidazol-2-yl)amino] benzoate dimethanesulfonate (fut-187) a 13 week subacute toxicity study by gavage was done in cynomolgus monkeys at dosage levels of 0, 15, 45 and 135 mg/kg/day. deaths were seen in the 135 mg/kg/day group; with associated debility. the animals that died had high plasma levels of fut-187. little weight gain was seen in the 135 mg/kg/day group. there were no clear treatment related effects on ophthalmo ... | 1992 | 1296020 |
| pharmacokinetics, hydrolysis and aromatisation of norethisterone-3-oxime in female cynomolgus monkey. | norethisterone-3-oxime (neto) was administered to 3 female cynomolgus monkeys intragastrically and, after a wash-out period of 2-5 weeks, intravenously at a dose of 1 mg/kg. the radioactive dose of tritiated neto was 20 microci/kg for both treatments. for i.v. injection, a 30% propylene glycol/water solution and for i.g. administration an aqueous microcrystalline suspension was used. excretion of radiolabel in urine and feces was followed for 5 days and plasma samples were obtained up to 2 days ... | 1992 | 1301358 |
| lead exposure during different developmental periods produces different effects on fi performance in monkeys tested as juveniles and adults. | monkeys (macaca fascicularis) were dosed with 0 or 1500 micrograms/kg/day of lead as lead acetate according to one of four regimens: group 1, vehicle continuously from birth; group 2, lead continuously from birth; group 3, lead from birth to 400 days of age and vehicle thereafter; group 4, vehicle from birth to 300 days of age and lead thereafter. blood lead values of the three treated groups were approximately 20-35 micrograms/dl, depending on age. performance on a multiple fixed interval-fixed ... | 1992 | 1302302 |
| sampling of cortical and trabecular bone for lead analysis: method development in a study of lead mobilization during pregnancy. | the paper describes a methodological approach to the investigation of maternal-fetal transfer of lead in a non-human primate species, with particular focus on skeletal tissue, which is known to be a site of lead deposition. eight female cynomolgus monkeys were dosed with lead acetate during gestation, and in four of the animals, the isotopic composition of the lead was modified by enriching the amount of the stable isotope 204pb included in the dose. biopsy and dissection procedures for the prep ... | 1992 | 1302308 |
| experimental infection of cynomolgus and african green monkeys with human herpesvirus 6. | cynomolgus and african green monkeys were inoculated with human herpesvirus 6 (hhv-6). an antibody response was first observed 10 days and 5 days after inoculation of cynomolgus monkeys and african green monkeys, respectively, and was detectable for the duration of the experiment (33 days). hhv-6 dna was first detected by the polymerase chain reaction in mononuclear cells of one cynomolgus monkey and one african green monkey 10 days after virus inoculation, and in a total of three of four cynomo ... | 1992 | 1321207 |
| response of colostrum-deprived cynomolgus monkeys to intragastric challenge exposure with simian rotavirus strain sa11. | the infectivity and pathogenic potential of a cell culture-adapted simian rotavirus was evaluated in colostrum-deprived newborn and infant cynomolgus macaques (macaca fascicularis). intragastric challenge exposure with the simian rotavirus strain sa11 on postpartum day 2 induced diarrhea in 5 of 5 colostrum-deprived newborn monkeys. compared with sham-inoculated controls, 3 of the 5 inoculated monkeys also manifested reduced body weight gain during the initial 5 days after challenge exposure. ro ... | 1992 | 1326241 |
| the preclinical safety evaluation of human monoclonal antibody against cytomegalovirus. | the human monoclonal antibody against cytomegalovirus (mab c23) was examined pharmacokinetically and toxicologically as part of the preclinical studies prior to approval for human use. rats given repeated intravenous administrations of mab c23 produced no antibodies against mab c23 and maintained a blood mab c23 level in a dose-dependent manner. however, pregnant rabbits produced antibodies against mab c23. the half-life of mab c23 in plasma was 15.9 days in rats, which was similar to that of no ... | 1992 | 1327929 |
| combined simian hemorrhagic fever and ebola virus infection in cynomolgus monkeys. | simian hemorrhagic fever (shf) virus and a new strain of ebola virus were isolated concurrently in recently imported cynomolgus monkeys (macaca fascicularis) being maintained in a quarantine facility. ebola virus had never been isolated in the u.s. previously and was presumed to be highly pathogenic for humans. a chronology of events including measures taken to address the public health concerns is presented. the clinicopathologic features of the disease were abrupt anorexia, splenomegaly, marke ... | 1992 | 1318446 |
| pulmonary cestodiasis in a cynomolgus monkey (macaca fascicularis). | cestodiasis in primates has been noted historically to occur quite frequently, although tissue damage and clinical signs may or may not be apparent. larval cestodes, such as hydatid cysts or cysticercus cysts, are known to cause extensive tissue damage, while other larval cestodes, such as tetrathyridia, cause minimal damage to the host. this case history concerns an apparently healthy cynomolgus monkey that was part of a surgical study. during the study, all parameters were normal. the monkey d ... | 1992 | 1318447 |
| "primatization" of recombinant antibodies for immunotherapy of human diseases: a macaque/human chimeric antibody against human cd4. | immunoglobulin variable region genes from non-human primates, cynomolgus macaques, were shown to have 85%-98% homology with human immunoglobulin sequences and yet macaques are phylogenetically distant enough to respond against conserved human antigens. immunoglobulin genes were isolated from monkeys immunized with human cd4 antigen and a human/monkey chimeric anti-cd4 antibody with 91-92% homology to human immunoglobulin framework regions was cloned and expressed. the antibody has an apparent af ... | 1992 | 1369023 |
| effects of a bisphosphonate on experimental periodontitis in monkeys. | bisphosphonates have been shown to increase bone mass in estrogen-deficient patients by inhibiting osteoclast activity. the purpose of this study was to measure clinical and radiographic effects of a bisphosphonate on periodontitis development in monkeys. twenty-seven (27) adult cynomolgus monkeys were studied. after quarantine, baseline data were obtained including plaque index, gingival index, clinical probing depth measurements, and intraoral radiographs. standardized radiographs were analyze ... | 1992 | 1328593 |
| intranuclear inclusions in the pituitary gland of cynomolgus monkeys. | in a 3-month oral toxicity study of a pharmaceutical agent, intranuclear inclusions were seen in the secretory cells of the pars anterior of the pituitary gland of 22 of 40 cynomolgus monkeys, with similar incidences in control and dosed groups. all monkeys were clinically healthy. electron microscopic examination revealed that the intranuclear inclusions were cytoplasmic invaginations. | 1992 | 1329181 |
| demonstration of chlamydial rna and dna during a culture-negative state. | trachoma is a common blinding disease of humans caused by ocular infections with chlamydia trachomatis. the cynomolgus monkey is a valuable primate model for the detection, pathobiology, and treatment of this infection. we have used this model system to compare the relative ability of tissue culture, direct fluorescence cytology, a modified polymerase chain reaction, and rna blotting to detect c. trachomatis following primary infection and reinfection over 34 weeks. six cynomolgus monkeys were g ... | 1992 | 1373404 |
| cortical connections of the inferior arcuate sulcus cortex in the macaque brain. | injections of the retrograde/anterograde tracers wheat germ agglutinin-horseradish peroxidase (wga-hrp) into the cortex along the banks of the inferior limb of the arcuate sulcus in the cortex of 4 macaque monkeys (macaca fascicularis) were used to investigate its cortico-cortical connections. all injections produced transported label within the sulcus principalis, the ventral lateral prefrontal cortex, the anterior cingulate sulcus and the dorsal insular cortex. the distribution of label within ... | 1992 | 1374284 |
| sk&f 104353, a selective leukotriene receptor antagonist, inhibits leukotriene d4- and antigen-induced bronchoconstriction in cynomolgus monkeys. | the ability of sk&f 104353 to prevent and reverse leukotriene (lt) d4- and antigen (ag)-induced bronchoconstriction was examined in anesthetized, spontaneously breathing cynomolgus monkeys. aerosol administration of ltd4 (10 micrograms/ml; 20 breaths) produced a sustained increase in pulmonary resistance and decrease in dynamic lung compliance. aerosolized sk&f 104353 (150 breaths, 0.3 or 4.4 mg/ml) administered 15 min prior to ltd4 challenge antagonized these changes in a dose-dependent manner. ... | 1992 | 1332792 |
| ocular dominance columns in area 17 of old world macaque and talapoin monkeys: complete reconstructions and quantitative analyses. | the effects of monocular deprivation on cytochrome-oxidase (co) expression were used to reveal ocular dominance columns in flatmounts of the striate cortex in macaque (macaca fascicularis) and talapoin (miopithecus talapoin) monkeys. this procedure allowed the first direct visualization of the complete pattern of ocular dominance bands in macaque monkeys, and less complete reconstructions in talapoin monkeys. in a second macaque monkey, the ocular dominance organization was revealed by injecting ... | 1992 | 1375096 |
| responses of spinothalamic tract neurons to mechanical and thermal stimuli in an experimental model of peripheral neuropathy in primates. | 1. an experimental peripheral neuropathy (epn) was induced in three monkeys (macaca fascicularis) by ligation of spinal nerve l7. behavioral responses to innocuous mechanical stimuli were tested before and after the surgery. two weeks after the nerve ligation, the activity of spinothalamic tract (stt) neurons was recorded on both sides of the spinal cord with the animal under general anesthesia. responses of the stt neurons to the following stimuli applied to the skin were recorded: graded mecha ... | 1992 | 1337100 |
| wild long-tailed macaques (macaca fascicularis) in thailand are highly infected with gamma herpes virus but not with simian t-lymphotropic retrovirus of type 1. | | 1992 | 1339088 |
| serological survey of a captive macaque colony in china for antibodies to simian type d retroviruses. | sera from 510 macaques consisting of macaca mulatta, macaca assamensis, macaca fascicularis, macaca nemestrina, and macaca arctoides were investigated for antibodies to simian aids type d retrovirus (srv) by elisa and western blot with viral antigens purified from supernatants of srv-1 infected cell cultures. of these monkeys, 104 were seropositive by elisa; only 23 were confirmed by western blot. the true positive reaction to srv was found in 15 of 463 (3.2%) m. mulatta and eight of eleven (72. ... | 1992 | 1339171 |
| sympathetic nerve anatomy in the cavernous sinus and retrobulbar orbit of the cynomolgus monkey. | we present new information regarding the sympathetic nerve anatomy in the cavernous sinus and retrobulbar orbit of the cynomolgus monkey. postganglionic sympathetic nerves were identified using an immunoperoxidase technique in which the primary antiserum was directed against tyrosine hydroxylase, the rate-limiting enzyme in norepinephrine synthesis. our work is unique in adapting this staining method to paraffin-embedded tissue. this technique allows sympathetic nerve fibers to be distinguished ... | 1992 | 1348181 |
| monoclonal antibodies against human t cell adhesion molecules--modulation of immune function in nonhuman primates. | the cytotoxic t cell is thought to be a primary effector of allograft rejection. in vitro studies have demonstrated that the interaction between cytotoxic t cells and target cells involves cell surface adhesion molecules that result in conjugate formation, with subsequent antigen recognition, t cell activation, and target cell lysis. experiments have also demonstrated the ability of monoclonal antibodies with specificity for two human t cell adhesion molecules, lymphocyte function associated (lf ... | 1992 | 1348883 |
| metabolism and pharmacokinetics of the anti-varicella-zoster virus agent 6-dimethylaminopurine arabinoside. | the metabolism of 6-dimethylaminopurine arabinoside (ara-dmap), a potent inhibitor of varicella-zoster virus replication in vitro, was studied in rats and cynomolgus monkeys. rats dosed intraperitoneally or orally with ara-dmap excreted unchanged ara-dmap and one major metabolite, 6-methylaminopurine arabinoside (ara-map), in the urine. they also excreted allantoin and small amounts (less than 4% of the dose each) of hypoxanthine arabinoside (ara-h) and adenine arabinoside (ara-a). the relative ... | 1992 | 1318679 |
| possible influence of measles virus infection of cynomolgus monkeys on the outcome of the neurovirulence test for oral poliovirus vaccine. | macaque monkeys are susceptible to measles infection which triggers temporary immuno-depression similar to the well known phenomenon in humans. it is known that feral monkeys become infected with measles virus when they are exposed to humans. since macaca mulatta and m. fascicularis are species used to assay the neurovirulence of oral poliovirus vaccine, the immunodepression caused by measles infection of the test monkeys could significantly alter the results of the neurovirulence test. the seru ... | 1992 | 1319180 |
| a monkey model for epstein barr virus-associated lymphomagenesis in human acquired immunodeficiency syndrome. | high-grade malignant nonhodgkin's lymphomas--five lymphoblastic, three pleomorphic, and two immunoblastic--developed in 10/25 cynomolgus monkeys (macaca fascicularis) followed for up to 746 d after infection with simian immunodeficiency virus, strain sivsm. these lymphomas were shown to be associated with an epstein-barr (eb)-like cynomolgus b-lymphotropic herpesvirus (cblv) by electron microscopy, by southern blot hybridization with probes against human ebv, and by the expression of antigens co ... | 1992 | 1319458 |
| musculotopic organization of the hypoglossal nucleus in the cynomolgus monkey, macaca fascicularis. | the movements of the tongue in feeding and vocalization are enabled by a complex system of interdigitated muscle fibers in the tongue body. because of this complexity, the detailed anatomical connections between individual intrinsic tongue muscles and corresponding motoneurons in the hypoglossal nucleus have not been described for any mammal. in this study we describe the distribution of retrogradely labeled neurons in the hypoglossal nucleus, following injections of wheat-germ agglutinin-horser ... | 1992 | 1383289 |
| changes in brain catecholamines and dopamine uptake sites at different stages of mptp parkinsonism in monkeys. | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) has been shown to produce parkinsonism in primates. we have studied the changes in brain catecholamines and the distribution of desipramine insensitive mazindol binding sites in mptp parkinsonian primates at different levels of parkinsonism. thirty-seven monkeys (macaca fascicularis) were utilized in this study. twelve naive animals received no treatment and served as controls. twenty-five animals were rendered parkinsonian with serial injectio ... | 1992 | 1356591 |
| glutamate-immunoreactive terminals synapse on primate spinothalamic tract cells. | glutamate has been shown to excite spinothalamic tract (stt) neurons and has been localized to primary afferent neurons, spinal cord projection neurons, and interneurons in the spinal cord dorsal horn. the likelihood that glutamate-immunoreactive (glu-ir) terminals directly innervate stt neurons was investigated. for these studies three lamina iv or v stt cells in the lumbar spinal cords of three monkeys (macaca fascicularis) were identified electrophysiologically and characterized. two were ide ... | 1992 | 1357007 |
| evaluation of a stable cck agonist (a68552) in conditioned avoidance responding in mice, rats, and primates: comparison with typical and atypical antipsychotics. | in a variety of in vivo and in vitro tests, cholecystokinin (cck) has been shown to produce effects that would suggest a functional antagonism of dopamine. on that basis, it has been hypothesized that cck could have antipsychotic effects. we compared the cck agonist, a68552, to the antipsychotics haloperidol (hal), clozapine (cloz) and sulpiride (sulp) in various forms of conditioned avoidance using rats, mice, and cynomolgus monkeys. in rats, hal disrupted both acquisition of a conditioned shel ... | 1992 | 1359571 |
| oxidation of aldose reductase inhibitors alo-4114 and alo-3152 catalyzed by liver microsomes. | rat and cynomolgus monkey liver microsomes catalyze the oxidation of 2.7-difluoro-4.5-dimethoxyspiro (9h-fluorene-9,4'-imidazolidine)-2',5'-dione (alo-4114) to its monomethoxymetabolite (alo-4417). formation of this product by o-demethylation of alo-4114 is catalyzed by nadph and oxygen-dependent microsomal enzymes with the properties of p-450 monooxygenases. the reaction is blocked by inhibitors selective for these enzymes and activity increases about 2-fold in rats pretreated with phenobarbita ... | 1992 | 1362951 |
| potentiation of brain natriuretic peptides by sq 28,603, an inhibitor of neutral endopeptidase 3.4.24.11, in monkeys and rats. | the depressor, natriuretic and cyclic gmp responses to several species of brain natriuretic peptide (bnp) were compared to atrial natriuretic peptide (anp) 99-126 in conscious spontaneously hypertensive rats (shr) and in conscious cynomolgus monkeys treated with vehicle or the selective neutral endopeptidase (nep 3.4.24.11) inhibitor n-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-beta- alanine (sq 28,603). in the conscious shr, the natriuretic and cyclic gmp responses to 3 nmol/kg i.v. rat bnp-32 g ... | 1992 | 1385630 |
| prostate specific antigen and prostatitis. i. effect of prostatitis on serum psa in the human and nonhuman primate. | prostate specific antigen (psa) has become a mainstay in the diagnosis and management of patients with prostate cancer. we have found, as have others, that it may be elevated in patients with prostatic inflammation. ten patients had clinical evidence of prostatitis and elevated psa levels. six of these had persistently elevated levels after antibiotic treatment. after transrectal ultrasonography and biopsy, two had findings of adenocarcinoma, and the rest had a pathologic diagnosis of acute or c ... | 1992 | 1372426 |
| antihypertensive treatment and regression of atherosclerosis. | reduction of high blood pressure has an effect on coronary mortality and morbidity lower than expected. one of the possible explanations is the different anti-atherogenic capacity of anti-hypertensive drugs. reduction of high blood pressure has, by itself, an anti-atherogenic effect, but, for some anti-hypertensive drugs, there is experimental and clinical evidence of anti-atherogenic properties. for calcium antagonists experimental data have been published reporting reduction of aortic lipidic ... | 1992 | 1389300 |
| disposition of beta-hexachlorocyclohexane, p,p'-ddt, and trans-chlordane administered subcutaneously to monkeys (macaca fascicularis). | to evaluate skin lipid analysis for the accumulation level of environmental pollutants, the correlations between organochlorine pesticide residues in adipose tissue, blood, and skin lipids of monkeys were studied. the mixture of beta-hexachlorocyclohexane (beta-hch), p,p'-ddt, and trans-chlordane was subcutaneously given to monkeys once weekly for 5 weeks at dose levels of 1 and 10 mg/kg. the chemicals distributed in adipose tissue, blood, and skin lipids were determined six times after the last ... | 1992 | 1372798 |
| retrograde transport of d-[3h]-aspartate injected into the monkey amygdaloid complex. | the possibility that certain of the afferents of the primate amygdaloid complex use an excitatory amino acid transmitter was evaluated by injecting d-[3h]-aspartate into the amygdala of two macaca fascicularis monkeys. the distribution of d-[3h]-aspartate labeled neurons was compared with those labeled with the nonselective retrograde tracer wga-hrp injected at the same location as the isotope. retrogradely labeled cells of both types were observed in a variety of cortical and subcortical struct ... | 1992 | 1374347 |
| inapparent ocular infection by chlamydia trachomatis in experimental and human trachoma. | there is substantial indirect evidence which suggests that chlamydia trachomatis can generate inapparent, persistent infections in human. to confirm this directly, we examined ocular chlamydial infection in both the cynomolgus monkey model of trachoma and in patient samples from a trachoma-endemic area. in monkeys, ocular infection was studied over time using direct immunofluorescence cytology (dfa) and a molecular hybridization screening system which targets chlamydial ribosomal rna. in eleven ... | 1992 | 1375138 |
| functional characterization of non-human primate erythrocyte immune adherence receptors: implications for the uptake of immune complexes by the cells of the mononuclear phagocytic system. | erythrocytes from primates express an immune adherence (ia) receptor that binds complement-opsonized immune complexes (ic) both in vivo and in vitro. we have analyzed the immunochemical and functional properties of the ia receptor from erythrocytes from species that have been used for in vivo ic clearance studies and have compared these properties to the human ia receptor (which is called complement receptor type 1, cr1). erythrocytes from all species (chimpanzee, baboon, rhesus and cynomolgus m ... | 1992 | 1376254 |
| stereoselective behavioral effects of lu 19-005 in monkeys: relation to binding at cocaine recognition sites. | the effects of the monoamine uptake inhibitor lu 19-005 ((+/-)-trans-3-(3,4-dichlorophenyl)-n-methyl-1-indanamine) and its (+) and (-) enantiomers, lu 20-042 and lu 20-043, were compared with those of cocaine and the selective dopamine uptake inhibitor gbr 12909 (1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine) in behavioral and radioligand binding experiments. behavioral experiments were conducted in groups of squirrel monkeys trained under fixed-interval schedules of reinf ... | 1992 | 1377395 |
| species differences in 5 alpha-androstane-3 beta,17 beta-diol hydroxylation by rat, monkey, and human prostate microsomes. | the 6 alpha-, 7 alpha-, and 7 beta-hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol by rat prostate microsomes appears to be catalyzed by a single, high-affinity cytochrome p450 enzyme. in the present study we have examined the hydroxylation of 5 alpha-androstane-3 beta,17 beta-diol by prostate microsomes from cynomolgus monkeys and from normal subjects and patients with benign prostatic hyperplasia. our results suggest that although rat, monkey, and human prostate microsomes catalyze the ... | 1992 | 1378714 |
| the role of natural killer cells and lymphokine activated killer cells in the pathogenesis of hepatic injury in hepatitis a [corrected]. | in order to clarify the mechanism of liver damage in hepatitis a, we studied the role of natural killer (nk) cells and lymphokine activated killer (lak) cells in non-specific immunological reactions using hepatitis a (hav) infected cells (jtc-12.p3 cell) using the 51cr release assay. no significant difference in specific cytotoxicity was observed between uninfected cells (jtc) and hav-infected cells (jtc-hav) to fresh and poly i:cor ril-2 pretreated peripheral blood mononuclear cells (pbmc) from ... | 1992 | 1343344 |
| clinical features and predictive markers of disease progression in cynomolgus monkeys experimentally infected with simian immunodeficiency virus. | to study the pathogenicity of simian immunodeficiency virus (sivsm) in cynomolgus monkeys in order to establish an animal model for human aids. | 1992 | 1348944 |
| selective d2 receptor stimulation induces dyskinesia in parkinsonian monkeys. | stimulation of d1 striatal receptors has been proposed as the main mechanism mediating levodopa-induced dyskinesia in parkinson's disease. we used (+)-phno, a selective d2 agonist, as the only treatment in 6 cynomolgus monkeys made parkinsonian by repeated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. all animals developed choreic dyskinesia after a mean treatment period of 12.8 days (range, 1-29). administration of the d1 antagonist sch-23390 1 hour before administration of (+)-p ... | 1992 | 1350718 |
| amino acids and n-acetyl-aspartyl-glutamate as neurotransmitter candidates in the monkey retinogeniculate pathways. | the identity of the neurotransmitter(s) in the mammalian retinogeniculate pathway is unclear. to investigate the possibility that some amino acids and certain dipeptides, such as n-acetyl-aspartyl-glutamate (naag), fulfill this function, changes in their concentration were measured in the optic tract, and the parvocellular and magnocellular segments of the lgnd of six monkeys (macaca fascicularis), seven days after right optic tractotomy. the lgnd was studied also in two additional macaques, thr ... | 1992 | 1350998 |
| quantification and excretion profiles of pteridines in primate urine. | biopterin, 6-hydroxymethyl-pterin, isoxanthopterin, neopterin and, pterin were quantified in stress-free collected spontaneous morning urine samples from callithrix jacchus, saguinus fuscicollis, saguinus labiatus, saimiri sciureus, presbytis entellus, cercopithecus albogularis, cercocebus torquatus, macaca fascicularis, hylobates concolor, pongo pygmaeus, and gorilla gorilla. in most species, biopterin was the most frequent urinary pteridine followed by neopterin. sex differences in biopterin a ... | 1992 | 1404333 |
| stereoselective renal tubular secretion of a new uricosuric diuretic, 6,7-dichloro-5-(n,n-dimethylsulfamoyl)-2,3-dihydro-2-benzofurancarboxyl ic acid (s-8666), in cynomolgus monkeys. | plasma concentration-time curves and urinary excretion of individual enantiomers of unchanged s-8666 and its n-monodemethylated metabolite, m-1, in male cynomolgus monkeys were measured after oral administration of racemic s-8666 at doses of 5, 10, and 50 mg/kg and also after intravenous injection at doses of 1, 5, and 10 mg/kg. the tmax values for individual enantiomers of s-8666 in fasted male monkeys were 30 min after oral administration. the auc values for s(-)-s-8666 were greater than those ... | 1992 | 1352207 |
| midbrain dopaminergic cell loss in parkinson's disease and mptp-induced parkinsonism: sparing of calbindin-d28k-containing cells. | computer imaging and immunohistochemical staining techniques were used to determine which midbrain dopaminergic (da) cells are spared in parkinson's disease (pd), and in animals treated with the da neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), and whether the spared cells contain the calcium-binding protein, calbindin-d28k (cabp). the pd patients had more than 55% fewer midbrain da neurons than age-matched normal subjects. the cell loss occurred within the combined substantia n ... | 1992 | 1353337 |
| pharmacokinetics and efficacy of structurally related spirohydantoin and spirosuccinimide aldose reductase inhibitors. | 1. six potent aldose reductase inhibitors (ari), three spirohydantoin (i to iii) and three spirosuccinimide (iv to vi) compounds, showed similar ic50 activities in vitro for the inhibition of rat lens aldose reductase, but their ed50 values in diabetic rats varied as much as 20-fold in the lens and 50-fold in the sciatic nerve tissue. pharmacokinetic studies were undertaken to investigate these findings. structure-pharmacokinetic relationships were studied following i.v. administration to cynomo ... | 1992 | 1413869 |
| effect of chronic treatment with (+)-phno, a d2 agonist in mptp-treated monkeys. | a group of four drug naive macaca fascicularis were rendered parkinsonian with the neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine and then treated chronically with (+)-phno, a potent d2 agonist. after several days, dyskinesia appeared in all animals. at this point, the daily dose of (+)-phno was replaced by a dose of the d1 agonist cy 208-243. the substitution by cy 208-243 reproduced the same dyskinesia observed with (+)-phno. the administration of the da synthesis inhibitor ampt (alp ... | 1992 | 1354166 |
| dopaminergic stimulation of oxytocin concentrations in the plasma of male and female monkeys by apomorphine and a d2 receptor agonist. | administration of the dopamine receptor agonist apomorphine causes a dose-dependent increase in plasma oxytocin concentrations and dose-specific behavioral changes in rodents. to investigate whether dopamine receptor agonists will elicit similar neuroendocrine and behavioral effects in primates, we administered graded doses of apomorphine and the respective dopamine d1 and d2 receptor agonists, cy 208-243 and ly 163502, to monkeys and monitored plasma concentrations of oxytocin and behavior. fiv ... | 1992 | 1355489 |
| prevention of hiv-2 and siv infections in cynomolgus macaques by prophylactic treatment with 3'-fluorothymidine. | the aim of this study was to determine the usefulness of human immunodeficiency virus type 2 (hiv-2) for in vivo evaluation of antiviral drugs in monkeys and to study if prophylactic treatment with 3'-fluorothymidine (flt) could prevent infection against a low challenge dose of hiv-2 or simian immunodeficiency virus (siv). protection against infection was assessed by virus isolation and polymerase chain reaction (pcr) on monkey peripheral blood mononuclear cells (pbmc) as well as by antibody and ... | 1992 | 1355658 |
| fk506-induced impairment of glucose metabolism in the primate--studies in pancreatic transplant recipients and in nontransplanted animals. | the effect of fk506 on glucose metabolism was studied in five cynomolgus monkeys after pancreatic transplantation and in 10 nontransplanted cynomolgus monkeys. we have clearly demonstrated that fk506 can induce hyperglycemia in these animals. in the orally treated nontransplanted animals the hyperglycemia was usually very mild (4.5-6.0 mmol/l). in one of the five transplanted animals, hyperglycemia was induced by the fk506 treatment, since histological signs of rejection were absent and since pl ... | 1992 | 1384189 |
| identification of an abundant monkey epididymal transcript encoding a homologue of human campath-1 antigen precursor. | a number of cdna clones encoding a small (0.5-0.6 kb) transcript have been isolated from a monkey (macaca fascicularis) epididymal cdna library. dna sequence analysis indicates that this abundant epididymal transcript is homologous to the human campath-1 (cdw52) antigen precursor, a gpi-anchored membrane glycoprotein previously described on lymphocytes and monocytes. | 1992 | 1384718 |
| therapeutic effects of arotinolol, a beta-adrenergic blocker, on tremor in mptp-induced parkinsonian monkeys. | the effect of arotinolol, a peripherally acting beta-adrenergic-blocking agent, on postural or kinetic tremor was studied in monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced parkinsonism. male cynomolgus monkeys (macaca fascicularis) were treated with three injections of mptp hydrochloride (0.3 mg/kg, i.v.) at an interval of 3-4 days, followed by several injections of the same dose every 7 days. four monkeys with persistent parkinsonian symptoms manifested for greater tha ... | 1992 | 1384970 |
| genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon. | epididymal glutathione peroxidase (gpx) has been suggested as a major factor in combating loss of fertility of spermatozoa due to lipid peroxidation. we report here the isolation and sequence of putative gpx cdnas from rat (rattus rattus) and cynomolgus-monkey (macaca fascicularis) epididymis, which exhibit marked sequence identity with known gpxs. in both species the cdnas encode predicted preproteins containing 221 amino acid residues. unlike other characterized gpx sequences, epididymal gpx m ... | 1992 | 1386734 |
| spontaneous hypercholesterolemia in cynomolgus monkeys: evidence for defective low-density lipoprotein catabolism. | spontaneously hypercholesterolemic (sh) cynomolgus monkeys were identified that have average plasma cholesterol of 202 mg/dl, while that in normal monkeys is 119 mg/dl. the ldl from these sh monkeys have lower affinity for fibroblast ldl receptors in vitro. the amount of ldl2 (1.030 mean value of d 1.063 g/ml) required to displace 50% of [125i]ldl was 3.8 micrograms/ml for normal ldl2 and 6.6 micrograms/ml for sh-ldl2. the binding affinity of ldl1 (1.019 mean value of d 1.030 g/ml) was the same ... | 1992 | 1390875 |
| species differences in urinary butadiene metabolites; identification of 1,2-dihydroxy-4-(n-acetylcysteinyl)butane, a novel metabolite of butadiene. | 1,3-butadiene (bd) is used in the manufacture of styrene-bd and polybutadiene rubber. differences seen in chronic toxicity studies in the susceptibility of b6c3f1 mice and sprague-dawley rats to bd raise the question of how to use the rodent toxicology data to predict the health risk of bd in humans. the purpose of this study was to determine if there are species differences in the metabolism of bd to urinary metabolites that might help to explain the differences in the toxicity of bd. the major ... | 1992 | 1394848 |
| heterogeneity of alveolar macrophages in experimental silicosis. | the alveolar macrophage (am) population has been shown to be heterogeneous in composition as well as in function. the aim of our study was to assess morphological and functional features of am in an experimental model of quartz-induced lung fibrosis by flow cytometric methods. twelve cynomolgus monkeys were exposed 8 hr/day, 5 days/week for 26 months to either normal atmosphere (n = 5) or 5 mg/m3 dq12 less than 5 microns quartz dust (n = 7). after 20 months of exposure, we studied am phagocytosi ... | 1992 | 1396469 |
| quantitative plasma disposition of retinol and retinyl esters after high-dose oral vitamin a administration in the cynomolgus monkey. | a solid-phase extraction technique followed by automated high-performance liquid chromatography sample elution was successfully used to evaluate the effect of three pharmaceutical parameters on the plasma profile of various forms of vitamin a after an oral dose to cynomolgus monkeys. the three parameters evaluated were the chemical form of vitamin a (retinol versus retinyl acetate), the vehicle (acetone/tween 20/water versus acetone/soybean oil), and the retinol dose (2, 10, and 50 x 10(3) retin ... | 1992 | 1397791 |
| noninvasive measurement of blood pressure in conscious cynomolgus monkeys. | systolic (sp), diastolic (dp), and mean arterial blood pressures (map) and pulse rate (pr) were recorded on treated and untreated conscious cynomolgus monkeys by the oscillometric method (dinamap 1846sx/p). each monkey was placed in a restraining tube with the cuff placed on the base on the shaved tail. measurements were taken on untreated animals once or twice a day for 4 weeks. the mean and standard deviations for sp, dp, map, and pr were approximately 121 +/- 17, 60 +/- 14, and 84 +/- 17 mm h ... | 1992 | 1397804 |
| effect of subchronic bis(tri-n-butyltin)oxide (tbto) oral administration on haematological parameters in monkeys: a preliminary report. | a preliminary study was conducted on adult male crab-eating monkeys (macaca fascicularis) orally exposed to bis(tri-n-butyltin)oxide (tbto) at doses of 0 and 160 micrograms/kg/day, 6 days/wk, for 22 wk. no treatment-related signs of toxicity or changes in body weight gain were detected during the course of the study. the haematological analyses performed every 2 wk indicated a decrease in total leucocyte count in the treated animals with significant values in wk 8, 10 and 22 of treatment. no dif ... | 1992 | 1398353 |
| protection in simian immunodeficiency virus-vaccinated monkeys correlates with anti-hla class i antibody response. | our earlier reports demonstrated that cynomolgus macaques vaccinated with either inactivated partially purified simian immunodeficiency virus (siv), fixed siv-infected c8166 (a human t lymphoblastoid cell line) cells, or fixed uninfected c8166 cells can be protected against a challenge infection with the 32h isolate of sivmac 251 (grown in c8166) (stott, e. j., w. l. chan, k. h. g. mills, m. page, f. taffs, m. cranage, p. greenway, and p. kitchin. 1990. lancet. 336:1538; stott, e. j., p. a. kitc ... | 1992 | 1402662 |
| is vasospasm related to proliferative arteriopathy? | although proliferative arteriopathy has been postulated to play a role in the etiology of vasospasm after subarachnoid hemorrhage (sah), histological and morphological studies examining cerebral vasospasm have produced conflicting results. to help settle this controversy, the authors used an in vivo label of cell division, bromodeoxycytidine, to assess cell proliferation in a primate model of sah. fifteen cynomolgus monkeys received a clot of either whole blood (11 animals) or red blood cells (f ... | 1992 | 1403117 |
| changes in optic disk characteristics and number of nerve fibers in experimental glaucoma. | we compared the change in cup/disk ratio and neuroretinal rim area-to-disk area to estimated change in the number of optic nerve fibers in 12 cynomolgus monkeys with unilateral experimental glaucoma. changes in the cup/disk ratios and neuroretinal rim area-to-disk area were estimated from stereoscopic optic disk photographs that were obtained before and after the development of increased intraocular pressure. change in the number of optic nerve fibers in the glaucomatous nerves was estimated by ... | 1992 | 1443015 |
| experimental allergic encephalomyelitis in cynomolgus monkeys. quantitation of t cell responses in peripheral blood. | chronic relapsing-remitting experimental allergic encephalomyelitis (eae) was induced in cynomolgus monkeys by a single immunization with a homogenate of human brain white matter (bh) in adjuvant. proliferative t lymphocyte responses to bh, to myelin basic protein (mbp), but not to proteolipid protein, were detected in peripheral blood mononuclear cells (pbmc) of all animals and persisted until their death or, in surviving animals, for greater than 10 mo postimmunization. responses of higher mag ... | 1992 | 1379611 |
| evidence for a substance p containing subpopulation in the primate suprachiasmatic nucleus. | immunohistochemical detection of substance p (sp) in the suprachiasmatic nucleus (scn) of the old world monkey, macaca fascicularis, was performed using two different rabbit polyclonal antisera. immunostaining revealed a large population of neurons located in the dorsal subdivision of the nucleus identified by nissl stain. this neuronal group represents the only cluster of sp-like immunoreactive (sp-ir) perikarya observed within the hypothalamus. in contrast with our present finding in the macaq ... | 1992 | 1380392 |
| the correlation between anterior-posterior translation and cross-sectional area of anterior cruciate ligament reconstructions. | total anterior-posterior translation is commonly used to assess the integrity of the cruciate ligaments and the success of reconstructive surgery. the purpose of this study was to determine, after surgical reconstruction of the anterior cruciate ligament with a biological graft, if total anterior-posterior translation correlated with graft length, cross-sectional area, or mechanical properties. these factors were investigated by analyzing data from three previous studies. these studies involved ... | 1992 | 1403302 |
| the peripheral nerve allograft in the primate immunosuppressed with cyclosporin a: i. histologic and electrophysiologic assessment. | nerve regeneration across peripheral nerve allografts and control autografts in primates immunosuppressed with cyclosporin a was quantitatively evaluated by electrophysiologic and histologic methods. twelve cynomolgus monkeys received 3-cm autografts and allografts in contralateral ulnar nerves. they were immunosuppressed with cyclosporin a at 25 mg/kg per day or placebo vehicle. morphometric analysis of nerve graft and distal nerve segments was assessed at 1 year after engraftment. quantitative ... | 1992 | 1448498 |
| the peripheral nerve allograft in the primate immunosuppressed with cyclosporin a: ii. functional evaluation of reinnervated muscle. | isometric contractile function was evaluated in primates receiving peripheral nerve allografts and autografts. twelve adult male cynomolgus monkeys received both sural nerve allografts and autografts to the ulnar nerve in opposite forearms. half the animals received cyclosporin a (csa) immunosuppression (25 mg/kg per day); the remaining animals received placebo. one year following nerve engraftment, isometric contractile muscle function was evaluated in reinnervated abductor digiti quinti and in ... | 1992 | 1448499 |
| astrocytoma in a cynomolgus monkey (macaca fascicularis). | | 1992 | 1448910 |
| immunocytochemical localisation of substance p-like nerves in the cardiac ganglia of the monkey (macaca fascicularis). | substance p-like immunoreactive (sp-ir) nerves formed 2 types of relationships with nerve cells in the cardiac ganglia of the monkey (macaca fascicularis). the first type consisted of varicose sp-ir nerve fibres that ramified throughout the cardiac ganglia, forming a loose network with several nerve cell bodies. the second type consisted of several nerve cell bodies enwrapped by a dense pericellular (basket-like) investment of varicose sp-ir nerve fibres. numerous sp-ir nerve fibres formed periv ... | 1992 | 1380495 |