| immunotherapy in equine sarcoid: a report of two cases. | | 1977 | 332676 |
| [mycobacterium bovis--independent species--and its identification (author's transl)]. | | 1977 | 333490 |
| tuberculin reactions in bulls and boars sensitized with atypical mycobacteria from sawdust. | | 1977 | 333885 |
| effector cells which mediate antibody-dependent cell-mediated cytotoxicity. ii. ontogeny of effector activity in murine spleen. | | 1977 | 334381 |
| bcg influence on 256 walker carcinosarcoma growth in rats in relation to adrenal cortex status. | bcg influence on antitumoral immunity varied in relation to the timing and the way of administration, as well as in relation to the adrenal cortex status of the animals. bcg administration several days before tumor grafting, but especially when mixed with tumoral cells determined a maximum antitumoral effect, while vaccination after the tumor had been formed enhanced its metastasization. the decrease of the endogenous corticoids secretion amplified the antitumoral effect of bcg, while exogenous ... | 1977 | 335488 |
| [significance of the leukocyte migration inhibition test (mit) in the study of cellular immunity]. | | 1977 | 335648 |
| serological responses in experimental bovine tuberculosis. | five two-year-old heifers were each inoculated intravenously with 0.02 mg m. bovis strain an5. clinical, haematological and microbiological observations were made during the course of the experiment and antibody levels were measured before and after infection by means of the indirect immunofluorescent antibody (ifa) and bentonite flocculation tests. all cattle developed m. bovis infection varying in severity from peracute tuberculous pneumonia resulting in death within 33 days to chronic progres ... | 1977 | 336017 |
| cellular source of interferons in the circulation of mice with delayed hypersensitivity. | the cellular origins of type i and type ii interferons released into the circulation of mice with delayed hypersensitivity were investigated. we determined the effect of treatment with various immunosuppressive agents, including cyclophosphamide, cycloheximide, antithymocyte serum, and whole-body x-irradiation, on the release of interferons after intravenous injection of specific (old tuberculin) or nonspecific (lipopolysaccharide) stimuli. the results suggest that (i) a heterogeneous population ... | 1977 | 336540 |
| suppression of immunity to mycobacterium lepraemurium infection. | after injection of 10(8) live mycobacterium lepraemurium (mlm) into the left hind footpad of mice, there is development of local swelling attributable to a granuloma of the cell-mediated immunity type. concomitant intravenous inoculation of live mlm delays and may even suppress footpad swelling, the effects being proportional to the intravenous dose of organisms. concomitant footpad infection and intravenous inoculation of 10(9) dead mlm also delays footpad swelling, but over a period of months ... | 1977 | 336544 |
| antigenic cross-reactivity between mycobacterium bovis (bcg) and leishmania donovani. | antigenic cross-reactivity was demonstrated between mycobacterium bovis (bcg) and leishmania donovani, using delayed hypersensitivity as a criterion. | 1977 | 336551 |
| scanning and transmission electron microscopy of leptomeningeal free cells: cell interactions in response to challenge by bacillus calmette-guerin. | | 1977 | 336881 |
| [nonspecific reactions of cattle to tuberculin]. | | 1977 | 337643 |
| high-viability lyophilized bacille calmette-guérin vaccine produced by deep-culture technique. | evidence suggests that bacille calmette-guérin (bcg) vaccine for use in cancer immunotherapy should have the following characteristics: high viability which is maintained on storage; high ratio of live to dead cells; high proportion of single cells; and low content of soluble antigen. the production of a vaccine with these characteristics was accomplished by use of a deep-culture technique. the medium was modified proskauer and beck medium containing tween 80 and glucose. the mass culture was gr ... | 1977 | 337895 |
| ocular tolerance of bacillus calmette-guerin organisms. | the results of this investigation indicate that 5 x 10(6) and 5 x 10(8) viable bacillus calmette-guerin (bcg) organisms (mycobacterium bovis strain) can be safely administered in the subconjunctival region of the eye of new zealand albino rabbits without producing toxic effects locally or within the eye. this study provides a format for testing the applicability of bcg immunotherapy for experimental melanomas. | 1977 | 337945 |
| lupus vulgaris and mycobacterium bovis: a case report. | | 1977 | 337961 |
| immune interferon. i. production by lymphokine-activated murine macrophages. | | 1977 | 338310 |
| antibody response in rabbits to immunization with mycobacterium leprae. | mycobacterium leprae purified from liver tissue of an infected armadillo (the a/10 preparation) was tested for antigenic composition by immunization of rabbits and characterization of the antibody response by crossed immunoelectrophoresis. the rabbit antisera detected seven distinct components in the m. leprae preparation. this number is far lower than in similar experiments with other mycobacteria. the m. leprae sonic extract gave far fewer lines after polyacrylamide gel electrophoresis and sta ... | 1977 | 338491 |
| the incidence of tuberculosis in lechwe (marsh antelope). | of the 238 specimens of tissue collected from 70 lechwe (marsh antelope) 79 yielded m. bovis, 1 yielded a mixed growth of m. bovis and an 'atypical' mycobacterium and 6 yielded 'atypical' mycobacteria; the 'atypical' mycobacteria were probably contaminants. of the 63 lechwe killed as a 1 in 10 random sample from four herds, m. bovis was obtained from 21 animals, indicating that 33% of wild lechwe are infected with tuberculosis. | 1977 | 339450 |
| immunoprophylaxis against african trypanosomiasis. | | 1977 | 339684 |
| cellular immunity and the parasite. | | 1977 | 339685 |
| skin testing, fecal culture, and lymphocyte immunostimulation in cattle inoculated with mycobacterium paratuberculosis. | fourteen calves at 21 days of age were experimentally inoculated with 100 mg (wet weight) of mycobacterium paratuberculosis. three calves were inoculated orally, 4 intravenously, and 7 subcutaneously. lymphocyte immunostimulation, fecal culture, and intradermal tuberculin skin testing were done between 112 to 150 days following exposure. lymphocyte immunostimulation test results, conducted at 112 days after inoculation, showed all animals positive to mycobacterium avium purified protein derivati ... | 1977 | 339793 |
| in vitro stimulation of bovine peripheral blood lymphocytes: suppression of phytomitogen and specific antigen lymphocyte responses by aflatoxin. | the effects of aflatoxin b1 on responses of the peripheral blood lymphocytes (pbl) of 2 normal animals to phytohemagglutinin, concanavalin-a, and pokeweed mitogen and of the pbl of 2 mycobacterium bovis-infected animals to phytohemagglutinin and purified protein derivative of m bovis (ppd) were studied. aflatoxin concentrations of greater than or equal to 10 microgram/ml significantly suppressed the lymphocyte response of normal animals to the phytomitogens. lymphocyte response of m bovis-infect ... | 1977 | 339794 |
| immunization of mice after airborne infection with various strains of bcg. | the growth of 6 strains of bacillus calmette-guérin (bcg) in the lungs of mice was compared after direct implantation into those organs. bacilli of the connaught, pasteur, phipps, and tice strains multiplied appreciably in the lungs and disseminated into the spleen in contrast, bcg birkhaug and glaxo strains did not replicate in the lungs or spread to the spleen. the immunizing ability of 3 of these strains was examined in more detail. aerosol infection with bcg glaxo, pasteur, or phipps strains ... | 1978 | 339795 |
| chronic experimental interstitial pneumonitis in the rabbit. | the effects on the lungs of chronic aerosol and intravenous antigen challenges in preimmunized and control rabbits were studied. soluble and particulate antigens included ovalbumin, keyhole limpet hemocyanin, antigen-adsorbed latex particles, glutaraldehyde cross-linked ovalbumin, and killed bacille calmette-guérin (bcg). despite the development of acute alveolitis in sensitized animals, chronic aerosol challenge with both soluble and particulate antigens failed to produce chronic interstitial l ... | 1978 | 339798 |
| production of thymocyte-stimulating factor by murine spleen lymphocytes: cellular and biochemical mechanisms. | | 1978 | 340057 |
| pulmonary tuberculosis due to bcg in a technician employed in a bcg laboratory. | x-ray examination of the lungs of a laboratory technician in the bcg department of the statens seruminstitut, copenhagen revealed a lung tumour and possible signs of tuberculosis. the diagnosis was confirmed by macroscopic and histopathological examination of lung tissue removed by surgery. subsequent bacteriological examination showed the infection to have been caused by bcg. the possibility is discussed of whether the condition had developed from a metastatic lesion following bcg vaccination, ... | 1977 | 340075 |
| echinococcus multilocularis in the mouse: the in vitro protoscolicidal activity of peritoneal macrophages. | | 1977 | 340398 |
| [immunotherapy of lung cancer using bcg cell-wall skeleton]. | | 1977 | 340747 |
| quantitation of seven elements in mycobacterium phlei and mycobacterium bovis by neutron activation analysis. | quantitative determination of the elements potassium, sodium, manganese, magnesium, iron, cobalt and zinc was performed in mycobacteria by neutron activation analysis. mycobacterium phlei atcc 19 249 at different phase of growth (4, 8, 13, 23 and 37 days old cultures), and 14 days old mycobacterium bovis bcg cultures and uninoculated semi-synthetic sauton culture media were examined. the elements studied could be divided into three groups; sodium, potassium and magnesium could be regarded as maj ... | 1977 | 341656 |
| humoral and cell-mediated immune responses in foetal sheep following vaccination with bcg. | | 1977 | 341872 |
| a study of maternal lymphoid organs and the progeny following treatment with immunomodulating agents during pregnancy. | whether differences in foetoplacental weight and post-implantation mortality in rodents are secondary to heterosis and inbreeding depression or antigenic differences between mother and foetus has been a continuing controversy. to determine whether non-specific depression or stimulation of the maternal immune system affects the success of the foetoplacental allograft, groups of virgin fischer (ag-b1) females of similar age and weight mated with da (ag-b4) males were treated with daily intraperito ... | 1977 | 342160 |
| secretion of antimycobacterial fatty acids by normal and activated macrophages. | cellular resistance to facultative intracellular parasites has been studied by determining the antimycobacterial activity and the amount of fatty acids in sera and in heptane extracts of freshly collected and 24-h-cultured normal and activated guinea pig alveolar macrophages and liver cells. the quantity and the antimycobacterial activity of extractable fatty acids were determined by gas chromatography and the agar plate diffusion test, respectively. these determinations showed that heptane extr ... | 1978 | 342410 |
| infection with bacillus calmette-guérin activates murine thymus-independent (b) lymphocytes. | thymus-independent (b) lymphocytes from bcg-infected mice respond with enhanced or depressed levels of proliferation relative to the nonspecific levels of stimulation induced by tuberculin. the type of response obtained depends on how bcg was administered and the source of the lymphocytes. the proliferation of splenic b lymphocytes was depressed when bcg was given i.v. and unchanged when bcg was given subcutaneously, whereas the lymph node b cell response was enhanced regardless of the route of ... | 1978 | 342604 |
| cell migration from clotted plasma droplets in vitro: development of a new method for mif assay. | a new in vitro method for mif assay has been developed using cells contained in clotted plasma droplets. it gives results concordant with the capillary tube method for h37 ra mycobacteria sensitized mice and ppd sensitized healthy persons. the technique is applicable to any migratory cell population and requires only a small number of cells for performance. it is technically simple, not time consuming and practicable both in patients and experimental animals. | 1978 | 342613 |
| coupling ppd to tumour cells enhances their antigenicity in bcg-primed mice. | | 1978 | 342968 |
| infection of clethrionomys g. glareolus schreb. (red mice) with mycobacterium bovis injected intravenously. | | 1977 | 343492 |
| enhancement of immune responses: purified protein derivative- and indomethacin-enhancement of mitogen- induced dna synthesis and in vitro antibody responses. | | 1978 | 343662 |
| enhancement of the antibody response in vitro by bcg. | the addition of heat-killed bcg to mouse spleen cells in marbrook cultures causes an enhanced in vitro antibody response against sheep red blood cells, the extent depending on bcg concentration and on whether the spleen cells have been previously primed with bcg in vivo. moreover, a factor is produced by spleen cells incubated in vitro with bcg which enhances the antibody response of spleen cells from normal untreated mice, the extent of enhancement again depending on bcg concentration and the o ... | 1977 | 344094 |
| immunological adjuvants in cancer immunotherapy. | | 1977 | 344097 |
| host responses in adjuvant contact suppression of experimental rat tumours. | bcg (glaxo) and c. parvum (wellcome cn 6134) have been examined for suppression of growth of a range of syngeneically transplanted rat tumours, both carcinogen-induced and of spontaneous origin. treatment by locally applied adjuvant controlled growth of both immunogenic and non-immunogenic tumours, and the response to highly immunogenic tumours was not abolished by host immunosuppression with whole body irradiation known to abrogate induction of tumour-specific immunity. in addition, rat tumour ... | 1977 | 344098 |
| unanticipated effect of bcg in mice treated by radiotherapy. | female c57 bl/6 mice (6-8 weeks old) bearing the lewis or the mbl-2 tumor received a localized irradiation (1,600 rads; cobalt 60) three days after the tumor implantation. we compared the association of irradiation and immuno-bcg-f (1 mg/mice i.v.) with three control groups (no treatment, irradiation alone, immuno-bcg-f alone). the timing and number of bcg injections varied in the different sub-groups. results were improved in the lewis tumor system when bcg was injected just after the end of th ... | 1977 | 344099 |
| various modalities of local administration of bacterial immunostimulants in transplantable rat tumours and in primitive methylcholanthrene mouse tumours. | the frequent use of intra-lesional injection of bacterial immunostimulants is hampered by apparent rarity of susceptible tumours, absence of therapeutic effect on large tumours, lack of variety of experimental models, eventual traumatism which is feared in case of intra-lesional, and injection in visceral cancers. (1) methylcholanthrene induced primitive tumours in mice are more frequently susceptible when the carcinogen induction dosage is low (0.01 mg). (2) using transplantable rat tumours, on ... | 1977 | 344100 |
| experience with bcg adjuvant immunotherapy in stage ii malignant melanoma. | 23 "high risk" melanoma patients treated with bcg-ait are compared with a non-randomized control group of 35 stage ii melanoma patients receiving other treatment. the results are discussed. it has been noted that patients with weak initial bcg reactions survived longer than patients with strongly positive first bcg reactions. this observation could be interesting for the choice of immunotherapy. | 1977 | 344106 |
| randomized trial of chemoimmunotherapy for resectable and non-resectable gastrointestinal cancer. | two trials were carried out in order to compare, in two similar groups of patients, the efficacity of 5-fluorouracil (5fu) with or without bcg. the first trial comprised 159 patients with different forms of carcinoma. the differences in survival rate between the 77 patients treated with 5fu and the 82 patients who had received 5fu and bcg seem to be in favour of the combined treatment, but are not statistically significant. the second trial (20 cases treated with 5fu and 23 cases treated with 5f ... | 1977 | 344107 |
| clinical immunotherapy experiences in the southeastern cancer study group. | the southeastern cancer study group has been particularly interested in the use of immunological adjuvants in the treatment of melanoma and acute myelogenous leukemia. a study of chemotherapy versus chemoimmunotherapy in randomly selected patients with metastatic malignant melanoma revealed no significant increase in either complete remissions or overall survival in the group receiving chemoimmunotherapy. preliminary results in a study involving maintenance of patients with acute myelogenous leu ... | 1977 | 344110 |
| immunity to mycobacterium leprae infections induced in mice by bcg vaccination at different times before or after challenge. | viable suspensions of bcg, an attenuated strain of mycobacterium bovis, have been previously shown to immunize mice against infections with m. leprae. usually, the mice have been vaccinated about 1 month before challenge. experiments have now been carried out with single intradermal injections of bcg given before or after the m. leprae challenge. approximately equal immunizing effect was seen in one experiment when the bcg was given at -168, -119, -70, and -28 days relative to challenge. approxi ... | 1978 | 344208 |
| genetic differences in bcg-induced resistance to schistosoma mansoni are not controlled by genes within the major histocompatibility complex of the mouse. | induction of nonspecific resistance to schistosoma mansoni infection after the i.v. injection of viable bcg was investigated in outbred mice and a panel of inbred and h-2 congenic strains. significant protection was induced in cf1, a/j, c57bl/6, c57bl/10, dba/2, c57br, and sjl mice. balb/c mice were not protected whereas cba and c3h mice expressed intermediate degrees of protection. expression of the protective phenomenon is not controlled by genes within the mhc as shown by the marked differenc ... | 1978 | 344795 |
| septicemic infection in nude mice caused by a virulent strain of mycobacterium bovis. | following i.v. infection with 2.3 to 2 x 10(6) viable organisms of mycobacterium bovis strain ravenel, congentitally athymic nude (nu/nu) mice of balb/c background died earlier than their heterozygous (nu/+) counterparts, showing necrotic nodules in the heart and kidney with the involvement of liver and spleen. pulmonary lesions in nu/nu mice, however, were less severe than those of dead nu/+ mice. in the reticuloendothelial organs of nu/nu mice, macrophages loaded numerous acid fast bacilli wer ... | 1977 | 344950 |
| immune reactivity during aging. i. t-helper dependent and independent antibody responses to different antigens, in vivo and in vitro. | the immunological status during aging was assessed by measuring the antibody response of the long-lived (c3h/eb x c57bl/6j)f1 mice to various antigens in vivo and in vitro. in vivo, a decrease in antibody production to dnp and nip haptenic determinants coupled on to bgg, as well as the response to srbc, was observed. the decline was more pronounced in the igg as compared to igm antibodies. the results were recorded when various parameters such as antigen dose and kinetics of the response, were c ... | 1978 | 345009 |
| [activation of kupffer cells]. | | 1977 | 345012 |
| [infection caused by bovine tuberculum bacteria in humans in the netherlands during the period 1972-1975]. | | 1978 | 345133 |
| the influence of extracts from the skeletal muscle of guinea-pigs infected with myco bovis bcg-praha and/or with myco fortuitum on the viability of ehrlich ascites tumor cells. | description of results obtained by following the influence of muscle from guinea-pigs infected with myco bovis bcg-praha and/or myco fortuitum on the viability of ehrlich ascites tumor cells is presented. the muscle extracts were prepared from the striated muscles of the upper and lower extremities as well as the sternal muscle of guinea-pigs killed on the 1st, 15th, 35th and 70th days after infection with the above-mentioned mycobacterial strains. it follows from the results obtained that only ... | 1978 | 345136 |
| [tuberculous lesions in lymph nodes of swine. occurrence, localization, microbiological, epidemiological, and patomorphological studies (author's transl)]. | | 1978 | 345225 |
| [circulating antibody titres in experimental renal tuberculosis]. | | 1978 | 345268 |
| synthesis of vitamin b12 by various species of mycobacteria. | the synthesis of vitamin b12 by five reference strains of species of mycobacteria, the influence of cobalt upton the synthesis and the correlation between the phase of growth and quantitative biosynthesis of vitamin b12 were studied. assays were performed on cell extracts and culture filtrates using lactobacillus leichmannii atcc7830 (tube method). all five species synthesized vitamin b12, which could be deomonstrated both in cell extracts and in the culture filtrates. an optimum accumulation of ... | 1977 | 345687 |
| mesothelioma and local immunotherapy. | | 1978 | 345909 |
| similarities among factors that render macrophages tumoricidal in lymphokine and interferon preparations. | lymphokine preparations, including supernatants derived from antigen-stimulated bacillus calmette-guérin-immune spleen cell cultures and normal spleen cells incubated with insoluble concanavalin a, were compared with partially purified l-cell interferon for the ability to render resting macrophages nonspecifically tumoricidal in vitro. significant activation of macrophages by lymphokine preparations occurred at concentrations as low as 0.5 and 0.25% of the assay mixture for antigen-stimulated an ... | 1978 | 346202 |
| type i and ii interferons and migration inhibitory factor: production in mycobacterium bovis bcg-infected mice desensitized with old tuberculin or lipopolysaccharide. | mice with delayed hypersensitivity induced by infection with mycobacterium bovis strain bcg were desensitized by a single large dose of specific antigen (old tuberculin, ot) or a nonspecific interferon stimulus (bacterial lipopolysaccharide, lps). subsequent challenge of the desensitized animals revealed only a homologous hyporeactivity, that is, mice desensitized with ot showed decreased type ii and migration inhibitory factor (mif) responses to the specific antigen, which were unaffected by de ... | 1978 | 346489 |
| kinetics of the humoral and cellular immune response of guinea pigs after injection of the synthetic adjuvant n-acetylmuramyl l-alanyl-d-isoglutamine: comparison with freund complete adjuvant. | we studied the time course of humoral and cellular immunity of guinea pigs injected with the synthetic adjuvant n-acetylmuramyl l-alanyl-d-isoglutamine (mdp pasteur, 10 microgram) in freund incomplete adjuvant; the kinetics were compared with those obtained with freund complete adjuvant (50 microgram of whole mycobacterium butyricum). the antibody response to ovalbumin was faster and higher with mdp, but dropped sooner to a low level; the secondary response was, however, again higher for mdp tha ... | 1978 | 346491 |
| effect of trichinella spiralis infection on delayed hypersensitivity to heterologous antigens. | studies were initiated to determine the effects of the different phases of the nematode life cycle on the delayed-type hypersensitivity (dth) capabilities of the host. mice were injected intraperitoneally with 4 x 10(6) viable or heat-killed bcg at 0, 3, 7, 14 and 28 days after oral infection with 200 trichinella spiralis larvae. groups were tested for dth 28 days after bcg inoculation by the footpad swelling assay. infection with t. spiralis was found to suppress the response in mice administer ... | 1978 | 346495 |
| antibody activity against mycobacterium leprae antigen 7 during the first year of dds treatment in lepromatous (bl-ll) leprosy. | | 1978 | 347205 |
| chemoimmunotherapy of head and neck cancer. | the present review aims at developing a perspective for surgeons of the role of chemoimmunotherapy in the management of head and neck cancer. the biochemical pharmacology of high dose methotrexate with leucovorin "rescue" is also discussed. the need for a combined modality approach in the treatment of patients with this cancer is emphasized. | 1978 | 347963 |
| cell-mediated immunity in neonatal calves: delayed-type hypersensitivity and lymphocyte blastogenesis following immunization with a mycobacterial immunopotentiating glycolipid and tuberculoproteins of mycobacterium bovis. | | 1978 | 347995 |
| papulonecrotic tuberculid secondary to mycobacterium bovis. | a patient with papulonecrotic tuberculid had a pruritic papular eruption associated with constitutional symptoms. the eruption flared whenever the patient received low doses of prednisone to control symptoms of temporal arteritis. a cervical lymph node biopsy specimen demonstrated acid-fast bacilli, and mycobacterium bovis grew on the cultures. the eruption cleared completely with antituberculous therapy. this case demonstrated the clinicopathologic findings compatible with a diagnosis of papulo ... | 1978 | 348113 |
| the antileukemic effect of systemic non-specific bcg-immunostimulation vs systemic specific immunostimulation with irradiated isogeneic leukemic cells. | | 1978 | 348478 |
| general ideas concerning a vaccine against leprosy: a basis for discussion during the eleventh international leprosy congress. | | 1978 | 348611 |
| colonial morphology of bcg sub-stains related to their biological properties. | | 1978 | 348702 |
| bacille calmette-guérin infection in the mouse. regulation of macrophage plasminogen activator by t lymphocytes and specific antigen. | high levels of plasminogen activator (pa) were induced in mouse peritoneal macrophages by infection with bcg, 2-6 x 10(7) viable organisms intravenously, followed 3-4 wk later by intraperitoneal challenge with purified protein derivative (ppd) 2 days before harvest. macrophages obtained from infected animal without boosting showed little fibrinolytic activity, but challenge of bacille-calmette-guèrin (bcg)-primed peritoneal cells with ppd in culture also enhanced macrophage pa 4- to 10-fold. sti ... | 1978 | 349108 |
| induced immune destruction of long-surviving, h-2 incompatible kidney transplants in mice. | | 1978 | 349112 |
| gassing badgers. | | 1978 | 349854 |
| [hypersensitivity of the delayed type and formation of immunity during the infectious process]. | | 1978 | 349917 |
| [effect of cyclophosphamide on experimental tuberculosis in mice]. | | 1978 | 350115 |
| a rapid radiometric technique used to trap and quantitate 14co2 evolved by slow-growing microorganisms. | an apparatus to trap and quantitate 14co2 is described. when used to measure antibiotic effects on histoplasma capsulatum and mycobacterium bovis (bcg), there was an inverse quantitative relationship between 14co2 evolved and antibiotic concentration. the technique should prove useful for analyses that require trapping and quantitation of 14co2, including antimicrobial sensitivities of slow-growing organisms. | 1978 | 350366 |
| autologous bone marrow grafts in dogs treated with lethal doses of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. | hematological and immunosuppressive effects of various single doses of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (ccnu) were evaluated in the preclinical canine model. immune function appeared not to be impaired by treatment with ccnu, but severe myelotoxicity contributed to the death of 3 of 4 dogs given 10 mg ccnu per kg and 5 of 5 dogs given 15 mg ccnu per kg within 10 days after drug administration. infusions of autologous bone marrow protected 6 of 6 dogs receiving 15 mg ccnu per kg and ... | 1978 | 350384 |
| [tuberculosis induced by bovine mycobacteria (author's transl)]. | | 1978 | 350401 |
| trichinella spiralis: effects on the host-parasite relationship in mice of bcg (attenuated mycobacterium bovis). | | 1978 | 350600 |
| biochemical and functional characteristics of the plasma membrane of macrophages from bcg-infected mice. | a set of quantitative signs of activation, previously developed in studies of inflammatory peritoneal macrophages, has been applied to the study of immunologically stimulated peritoneal cells. mice that are infected systemically with bacillus calmette guérin (bcg) and then challenged locally with soluble mycobacterial antigens generate populations of cells that spread rapidly in culture, display an elevated pinocytic rate, ingest igmc-coated sheep erythrocytes, and have diminished levels of 5'-n ... | 1978 | 351053 |
| bone marrow colony-stimulating factor and tumor resistance-enhancing activity of postendotoxin mouse sera. | the passive transfer of postendotoxin mouse serum could enhance nonspecific resistance to the development of ta3-ha transplantable ascites tumor in mice. the postendotoxin serum was not directly cytotoxic to ta3-ha tumor cells in vitro, nor did it contain significant amounts of residual endotoxin, but it was rich in colony-stimulating factors (csfs). high-titer csf serum could be induced by endotoxic lipopolysaccharide (lps). nonendotoxic, lipid-free, and polysaccharide-rich hydrolytic breakdown ... | 1978 | 351621 |
| assessment of cell-mediated immunity in the rat utilizing the agarose-droplet cell-migration-inhibition correlate of delayed-type hypersensitivity. | | 1978 | 352353 |
| effect of bcg cell-wall skeleton on metastasis of syngeneic tumor in rats, with special reference to lymphocyte trapping. | oil-attached bcg cell-wall skeleton (bcg-cws) was demonstrated to have an activity inducing lymphocyte trapping in the draining node in rats. it acts also as a potent adjuvant for the lymphocyte trapping when injected into the growing syngeneic transplantable tumor. treatment with repeated intratumor injections into the primary tumor resulted in suppression of tumor growth in both primary and metastatic sites. even when the primary tumor escaped regression, inhibitory effect on metastatic spread ... | 1978 | 352783 |
| [electron microscopic study on the focal immune response in the choroid (author's transl)]. | pigmented rabbits were sensitized by subcutaneous injection of bcg together with freund's complete adjuvant and heat killed tubercle bacilli together with adjuvant. after the titer of serum antibody to bgg was elevated or tuberculin skin test became positive, choroiditis was induced in these eyes by an injection of bgg or ppd directly through the posterior sclera in the vicinity of the optic nerve. the eyes were enucleated at various intervals and the choroid was studied by light and electron mi ... | 1978 | 352883 |
| [tuberculosis in children]. | | 1978 | 352925 |
| increased bone marrow production of granulocytes and mononuclear phagocytes induced by mycobacterial adjuvants: improved recovery of leukopoiesis in mice after cyclophosphamide treatment. | the effects of complete freund adjuvant (cfa) or mycobacterium bovis bcg on leukopoiesis and on leukopoietic recovery from cyclophosphamide treatment in mice was studied. cfa injected subcutaneously or intraperitoneally resulted in increased blood granulocyte and monocyte counts, increased numbers of bone marrow granulocyte and mononuclear phagocyte progenitors, and increased hematopoietic colony-stimulating factor in the serum. furthermore, the quantitative cellular response within 24 h to an i ... | 1978 | 352938 |
| enhancement of lymphocyte blastogenic and delayed hypersensitivity skin responses by indomethacin. | incubation of mycobacterium bovis-sensitized bovine peripheral blood lymphocytes with concanavalin a or m. bovis purified protein derivative and indomethacin caused a consistent, statistically significant increase in [3h] thymidine uptake as compared to cultures without indomethacin. the kinetics of the response showed that indomethacin must be added to lymphocyte cultures within hours after mitogen or antigen addition for enhancement of [3h]thymidine uptake to occur. lymphocyte blastogenic res ... | 1978 | 352951 |
| [treatment of dysfunction of cellular immunity and the prospect for future]. | | 1978 | 353324 |
| mode of immunopotentiating action of bcg: macrophage activation produced by bcg-infection. | macrophage activation as measured by increased rate of carbon clearance and spreading of peritoneal macrophage was studied in mice infected with bcg, strain japan. bcg caused marked increase of the numbers of peritoneal cells and spread macrophages. the increases of spread macrophages reached a peak at the 3rd week of bcg infection introduced by the both routes of intravenous(i.v.) injection and foot pad(f.p.) injection. bcg also enhanced the clearance of carbon. in the case of bcg given i.v., t ... | 1978 | 353337 |
| a plea for the use of bcg vaccine against tuberculosis in the united states. | | 1978 | 353438 |
| the methanol extract residue (mer) of bacillus calmette-guerin in cancer immunotherapy. | | 1978 | 353752 |
| [acute, lethal miliary tuberculosis due to mycobacterium bovis]. | the authors report a case of lethal acute miliary with bovine tuberculous bacilli. they stress the main characteristics of this exceptional observation :--difficulties in isolating and identifying,--favourable disposition linked to age and to a depressed cellular immunity,--pathogenic interest in the mechanisms of late endogenous reinfestation and of suffocating acute evolution. | 1978 | 353769 |
| metastatic osteomyelitis following bcg vaccination. | an 8-year-old girl, who had been vaccinated with bcg without subsequent regional reactions, developed osteomyelitis in the left calcaneus 7 months later. the process healed after surgical treatment and chemotherapy for 1 year. culture from the bone abscess gave growth of mycobacteria which could not be distinguished from bcg. | 1978 | 354311 |
| fatal bcg infection in an immunocompetent girl. | a 6-year-old girl developed progressive symptoms of increased intracranial pressure starting 5 months after bcg vaccination. thirteen months later craniotomy revealed an epithelioid cell granuloma of the arachnoid occluding the foramen of magendie. no tubercle bacilli were found on histological examination. insertion of a pudenz shunt relieved the symptoms. six months later generalized bcg infection developed, and in spite of treatment with ethambutol, rifampicin and isoniazid for 10 weeks, deat ... | 1978 | 354316 |
| mycobacteria isolated from nasal secretions of tuberculin test reactor cattle. | nasal secretions of 103 holstein cows from a tuberculosis-infected herd in argentina were bacteriologically cultured for mycobacteria. mycobacterium bovis was isolated in 8.7% of the cultures. this method was useful for the detection of active tuberculosis with open lesions. other mycobacteria, most of which grew rapidly on culture media, were isolated in 32% of the cultures and were of little importance as sensitizing agents to mammalian tuberculin in experimental studies in guinea pigs. | 1978 | 354437 |
| stimulation of splenic prostaglandin levels by dnp-protein antigens. | | 1978 | 354798 |
| immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. i. use of bacterial adjuvants in induction of immunity demonstrable in winn tests. | | 1978 | 354799 |
| use of pyridine for differentiating mycobacterium leprae from other mycobacteria in direct microscopy. | the loss of acid-fastness by m. leprae after two-hour pyridine extractions, reportedly a specific test for differentiating m. leprae from all other mycobacteria, was verified on different materials obtained from leprosy patients, histologic sections from a fatal post-bcg vaccination case and smears prepared from pure cultures of 32 strains of 18 different mycobacterial species. under the conditions used, pyridine extraction led to complete loss of acid-fastness in m. leprae only in histologic se ... | 1978 | 355157 |
| serum from lps nonresponder c3h/hej mice does not support the formation of functional eac reagents. | serum from c3h/hej mice in contrast to serum from other mouse strains does not convert ea into eac. a factor in supportive serum permits nonsupportive c3h/hej serum to produce a functional eac-rosetting reagent. this factor is heat stable. its concentration in serum parallels the sensitivity of mice to lps. it is absent or inoperative when sensitivity is reduced on a genetic basis and increased when sensitivity is increased by treatment with bcg. | 1978 | 355548 |
| a comparison of the effects of t and macrophage-like suppressor cells on memory cell differentiation in vitro. | | 1978 | 355552 |
| functional heterogeneity of rabbit peritoneal and alveolar macrophages activated with mycobacterium bovis bcg. | the biological activity of rabbit peritoneal and alveolar macrophages activated with m. bovis bcg was investigated by use of tests measuring their phagocytic and staphylocidal properties. macrophages were separated in a discontinuous albumin gradient which yielded 4 to 5 bands depending on the source of the exudate. the peritoneal exudate had about 40% of cells recovered in band e and the alveolar exudate had about 35% in band c. there were not significant differences between the uptake by three ... | 1978 | 356130 |
| bovine tuberculosis in man--reinfection or endogenous exacerbation. | cattle tuberculosis was totally eradicated in sweden 20 years ago. twelve cases of bovine tuberculosis in man were reported in 1974 and 1975. all cases lived for many years in areas where cattle tuberculosis had previously been common. no recent source of infection could be demonstrated. these findings are in accordance with an exacerbation of a distant infection. | 1978 | 356255 |
| chemoimmunotherapy for disseminated malignant melanoma: a prospective randomized study. | twenty-eight patients with disseminated malignant melanoma were treated with dtic (250 mg/m2 iv, days 1--5) and actinomycin d (0.5 mg/day iv, days 1--5) at 5-week intervals. patients were randomly allocated to receive no immunotherapy or immunotherapy consisting of methanol extracted residue of bacillus calmette-guérin (0.5 mg intradermally; 100 microgram in five separate sites) every 5 weeks, concomitant with chemotherapy. of these 28 evaluable patients, 13 received chemoimmunotherapy with one ... | 1978 | 356970 |