| mechanism of nonspecific macrophage-mediated cytotoxicity: evidence for lack of dependence upon oxygen. | peritoneal macrophages elicited in c3h/hj mice by the i.p. injection of corynebacterium parvum were cytotoxic to allogeneic virus-transformed fibroblasts in vitro. cytotoxicity was demonstrated in a morphologic (plaque) assay, and quantitated by measuring macrophage-mediated inhibition of incorporation of 3h-thymidine by the target cells. the cytotoxic effect was well established by 6 hr of macrophage-fibroblast interaction, and was retained in cultures from which the supernatant was removed bef ... | 1978 | 340584 |
| immunotherapy of lung cancer. i. review of clinical trials in non-small cell histologic types. | | 1979 | 394836 |
| antitumor activity of corynebacterium parvum. | | 1978 | 343523 |
| fatal infection with pseudomonas aeruginosa in mice treated with cyclophosphamide and propionibacterium acnes. | | 1979 | 428451 |
| immunotherapy from malignant disease. | | 1978 | 348035 |
| aerobic and anaerobic bacterial flora of the maternal cervix and newborn gastric fluid and conjunctiva: a prospective study. | aerobic and anaerobic cultures were performed on cervical swabs from 35 mothers and their newborn infants' gastric aspirates and conjunctival sacs. four hundred seventy-nine isolates were obtained; 287 were aerobes and 192 were anaerobes. the cervical and gastric cultures overall yielded a similar flora, but this was not always the case when one compared mothers with their own newborn infants. the conjunctival cultures yielded about half of the number of bacteria per specimen that the gastric co ... | 1979 | 440845 |
| [porphyrin production of propionibacterium acnes]. | | 1979 | 442749 |
| lack of effect of immunotherapy with bcg and corynebacterium parvum on hepatic drug hydroxylation in man. | serial serum diphenylhydantoin and urinary 5-(p-hydroxphenyl)-5-phenylhydantoin concentrations were determined in 8 patients with malignant disease and 4 healthy volunteers on 2 separate occasions after an oral dose of diphenylhydantoin (500 mg). no significant difference was observed between metabolism before and 10 days after immunization with bcg or corynebacterium parvum. volunteers without intervening immunization similarly showed no difference. | 1979 | 444399 |
| some examples of interactions between drugs in cancer chemotherapy. | drug combinations in cancer treatment are widely utilized because they frequently result in better therapeutic activity than the single treatments. the mechanism(s) by which this can be achieved may reside in an enhanced chemotherapeutic effect or in reduced toxicity, it being difficult to dissociate the two aspects. to underline this difficulty, experimental studies will be reported. a first example illustrates the interaction between phenobarbital and cyclophosphamide. depending on the schedul ... | 1978 | 348085 |
| immunotherapeutic response of concanavalin a-bound l1210 vaccine enhanced by a streptococcal immunopotentiator, ok-432. | immunotherapeutic response to concanavalin a (con a)-bound l1210 murine leukemic vaccine and immunopotentiators was examined in histocompatible animals bearing a small burden l1210 leukemic cells. when combined with con a-bound vaccine, a streptococcal immunopotentiator, ok-432 (nsc b116209), prepared from streptococcus pyogenes, was potent in antitumor therapy and resulted in a number of cured animals. administration of either con-a-bound vaccine or ok-432 alone did not produce any beneficial e ... | 1979 | 445486 |
| chemoimmunotherapy in the management of primary stage iii ovarian cancer: a gynecologic oncology group study. | the effectiveness of chemoimmunotherapy was evaluated in 45 previously untreated stage iii ovarian cancer patients. response rate, progression-free interval, and survival were considerably better than in a similar group of 63 patients treated with a single alkylating agent alone. | 1979 | 445505 |
| [immuno-chemotherapy in patients with disseminated metastasizing stage iii melanoma. randomized study with methyl-ccnu versus c. parvum plus methyl-ccnu]. | 34 patients with disseminated malignant melanoma (stage iii) were randomized to the following therapy groups: chemotherapy (meccnu, nsc 99441; 200 mg/m2, given orally every 8 weeks), or immuno-chemotherapy (1 mg corynebacterium parvum i.v., on days 1-4 + meccnu 200 mg/m2 on day 8, repeated every 7 weeks). total therapy response rate was 33%; total and partial remissions were achieved in 26% of the patients receiving chemotherapy, and in 40% under immuno-chemotherapy. interim life table analysis ... | 1978 | 362293 |
| positive correlation between the levels of natural killer cells and the in vivo resistance to syngeneic tumor transplants as influenced by various routes of administration of corynebacterium parvum bacteria. | | 1979 | 455483 |
| macrophage activation and increased resistance to infection in immunosuppressed mice treated with corynebacterium parvum vaccine or pyran copolymer. | | 1979 | 458782 |
| quantitative and functional differences induced in bone marrow-derived mononuclear phagocytes by inflammatory stimuli. | | 1979 | 458783 |
| multimodal immunotherapy of primary gastrointestinal tumors in rats. 1. histologic correlation. | the effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. multimodal immune manipulation consisted of combinations of splenectomy, c. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. such immunologic intervention resulted in significant inhibition of tumor growth, and their metastasis. ten of 10 untreated rats, 8 of 8 rats treated with splenectomy alone and 10 of 10 rats treated with nor ... | 1978 | 363250 |
| [postoperative prevention of recurrence with intrapleural corynebacterium parvum in patients with stage i and ii bronchial carcinomas. ludwig lung cancer study i]. | the ludwig lung cancer group was created in 1977. participants are from austria, denmark, germany, norway, sweden, switzerland, and yugoslavia. 400 patients are randomized yearly. the clinical trial i investigating the role of c. parvum intrapleurally as adjuvant therapy in operable non-small cell lung cancer patients has been closed in february 1979 with a total accrual of 475 patients. the average follow-up time for these cases is approximately 8 months. it is early to make any definitive comp ... | 1979 | 462160 |
| immunomodulation by corynebacterium parvum. 1. variable effects on anti-sheep erythrocyte antibody responses. | corynebacterium parvum injected i.p. 1--16 days prior to i.p. antigen inoculation virtually abolished both igm and igg primary responses to 1 x 10(8) srbc. the suppression was significantly marked at antigen doses ranging from 1 x 10(6)--1 x 10(9) srbc but not at 5 x 10(9) srbc. as little as 56 microgram c. parvum caused a marked suppression of the response to 1 x 10(8) srbc. in secondary responses c. parvum given either one day before priming with 1 x 10(8) srbc or one day before secondary chal ... | 1978 | 363603 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. v. comparison of the effects of tilorone hydrochloride, levamisole, methanol-soluble fraction of mycobacterium butyricum, bcg, and a nonviable aqueous ether extract of brucella abortus preparation in treatment of mice with tumors. | | 1978 | 413929 |
| effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. comparative studies in normal and congenitally athymic (nude) mice. | clinically, it is important to know whether agents used for immunostimulation require the presence of functional thymus-derived (t) cells. previous studies showed that both bcg and c. parvum induced a macrophage-dependent enhanced in vivo listeria clearance and in vivo inhibition of a fibrosarcoma induced by 20-methylcholanthrene. these two models were re-evaluated in congenitally thymusless (nude or nu/nu) b10lp mice lacking functional t cells. in nu/nu mice, (1) bcg failed to enhance listeria ... | 1977 | 415917 |
| the effect of corynebacterium parvum on the proliferation of monocyte precursors in the bone marrow of mice. | the anti-tumour activity of c. parvum is thought to be mediated via the monocyte/macrophage system (scott, 1974). these cells originate from rapidly dividing precursors in the bone marrow and it might be at this level that c. parvum exerts its action. to test this hypothesis bone marrow t0 swiss mice has been cultured according to the method of bradley and metcalf (1966), which gives an index of the number of proliferating macrophage precursor cells at the time of sacrifice. experiments were set ... | 1977 | 415919 |
| choriogonadotropin-like antigen in an anaerobic bacterium, eubacterium lentum, isolated from a rectal tumor. | using the indirect fluorescein-labeled and indirect peroxidase-antiperoxidase-labeled immunohistochemical techniques, and utilizing both antiserum specific for the beta-subunit of choriogonadotropin and antiserum for the total hormone, we have demonstrated the presence of a choriogonadotropin-like immunoreactive material in a strain of eubacterium lenthum that was originally isolated from a rectal tumor. in contrast, both immunohistochemical reactions were negative when applied to a strain of co ... | 1979 | 468380 |
| conditions favouring the selection of either specific or non specific c. parvum-mediated, systemic antitumour immunity in mice. | accumulated data suggest that one of two antitumour mechanisms of c. parvum may predominate depending on the route of injection of c. parvum and its distribution in relation to the tumour. after systemic c. parvum the mechanism is considered to be immunologically non specific (i.e. not requiring tumour specific antigens) and mediated by c. parvum activated macrophages. after local injection of c. parvum the interaction (direct or lymph node mediated) between c. parvum and tumour specific antigen ... | 1977 | 415921 |
| further observations on the inhibition of tumor growth by c. parvum with cyclophosphamide. vii. effect of treatment prior to primary tumor removal on the growth of distant tumor. | the present investigations were directed toward determining whether primary tumor manipulation prior to its removal is advantageous for the control of metastases and survival. studies were carried out to ascertain whether 1) there is justification for delaying surgical removal of a primary tumor to permit preoperative administration of cyclophosphamide (cy) and/or c. parvum (cp) and 2) there is an advantage to administering the immunotherapy directly into a primary tumor. after operation, in all ... | 1979 | 421172 |
| effect of corynebacterium parvum on liver proliferation and regeneration. | | 1979 | 421219 |
| sensitivity to chemotherapeutic and immunomodulating agents of two mouse lymphomas and of a macrophage tumor. | the effect of treatment with 15 chemotherapeutic and 10 immunomodulating agents on the growth of t-cell lymphoma el-4, macrophage tumor j774, and b-cell lymphoma 70z/2 of the mouse has been studied using the prolongation of median survival time of tumor-bearing hosts as an index of therapeutic effectiveness. the survival time of mice bearing 70z/2 was prolonged more than 100% by single-agent therapy with actinomycin d, cyclophosphamide, 6-mercaptopurine, mitomycin c, and vinblastine; a similar r ... | 1979 | 476634 |
| the aerobic growth of propionibacterium acnes in primary cultures from skin. | although propionibacterium acnes ordinarily grows as an anaerobe, this organism was commonly seen on aerobic primary cultures (directly from skin) of the forehead, axilla, deltoid area, and antecubital fossa. on subculture, strains from aerobic primary cultures showed their normal anaerobic state. on repeated tests of the foreheads of 7 subjects over periods of 1 to 4 yr, 24% of all cultures were positive for propionibacteria (p. acnes) on aerobic culture. this phenomenon was equally common in c ... | 1979 | 422866 |
| conditions for effective bacillus calmette-guérin immunotherapy of postsurgical metastases of 13762a rat mammary adenocarcinoma. | we evaluated critical variables in bacillus calmette-guérin (bcg) immunotherapy of residual 13762a rat mammary adenocarcinoma. bcg was given intratumorally on day 7 of tumor growth and followed by primary tumor excisions on day 20. untreated animals died on about day 40 with axillary nodal and pulmonary parenchymal metastases. bcg-treated animals experienced prolonged survival, and some were cured. the highest dose (5.0 x 10(7) colony-forming units) of bcg was more effective than the lowest (0.5 ... | 1979 | 427785 |
| effects of corynebacterium parvum and bcg therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. i. changes in blood counts, serum immunoglobulins and lymphoid cell populations. | the effects of a single immunization of melanoma patients with bcg or c. parvum on the blood counts, serum immunoglobulin levels and lymphoid subpopulations were followed by multiple assays over 28 days. c. parvum produced a decrease in the white cell count, lymphocyte count and lymphoid t and sig+ cell numbers, which recovered within 1 week; bcg did not produce such a marked depression. both agents were associated with increases in t cell numbers and lymphocyte pha blastogenesis after the first ... | 1979 | 428146 |
| comparison of the in-vitro antitumor activity of peritoneal cells from mice injected with corynebacterium parvum and corynebacterium liquefaciens. | | 1979 | 478988 |
| immune response modulation by colonization of germfree rats with propionibacterium acnes. | propionibacterium acnes (oral and/or parenteral administration) had a modulating effect on antibody-and cell-mediated immune responses of germfree (gf) and monoassociated (ma) rats. in conventionally reared rodents, parenteral injection of killed p. acnes stimulated the splenic plaque-forming cell response to sheep erythrocytes. however, in gf rats and in rats monoassociated with viable p. acnes, parenteral injection of killed p. acnes antigen inhibited the plaque-forming cell response to sheep ... | 1979 | 397928 |
| non-specific and specific active immunotherapy in a b16 murine melanoma system. | conflicts amongst reports concerning the efficacy of both nonspecific and specific attempts at immunotherapy may be ascribed to different animal models utilizing tumors of different immunogenicity. we have selected the b16 mouse melanoma model as the example of a spontaneously occurring neoplasm that is histocompatible with the host and does have tumor-associated antigens. attempts to alter tumor growth or survival with nonspecific active immunotherapy as well as with specific active immunothera ... | 1979 | 480953 |
| laboratory induction and clinical occurrence of combined clindamycin and erythromycin resistance in corynebacterium acnes. | corynebacterium acnes strains cross-resistant to clindamycin and erythromycin were observed following long-term selection or mutagenic treatment in the laboratory. similar strains were found among clinical isolates from patients using clindamycin or erythromycin topically in the treatment of acne vulgaris. clindamycin resistance was never observed in the absence of resistance to macrolides or other lincosaminides. it is suggested that this resistance may result from an alteration of the 50s ribo ... | 1979 | 429800 |
| monocytes and macrophages in malignant melanoma iv. effects of c. parvum on monocyte function. | assays for the capacity of peripheral-blood monocytes (a) to mature in vitro into macrophages, (b) to reduce nitro-blue tetrazolium (nbt) and (c) to lyse antibody-coated human group a red cells, were applied to a group of 82 patients with histologically proven malignant melanoma. in patients with micrometastatic disease there was an enhancement of red-cell lysis and nbt reduction, suggesting that their monocytes are in some way "activated", whereas nbt reduction was suppressed in those with over ... | 1979 | 486312 |
| fc receptor-bearing and phagocytic cells in syngeneic tumours of c. parvum- and carrageenan-treated mice. | | 1979 | 486317 |
| adjuvant immunotherapy. | because systemic spread occurs early in the growth of many malignancies, control of occult micrometastases must be an integral part of cancer treatment. for this reason, surgery and radiation therapy alone may fail to achieve a cure despite eradication of the primary tumor. chemotherapy is potent and systemic in its effects but kills tumor cells by first-order kinetics so the last cancer cell may not be eliminated. an agent is needed that can selectively attack and destroy small numbers of tumor ... | 1978 | 399764 |
| adjuvant intralesional and systemic corynebacterium parvum immunotherapy for surgically treated head and neck cancer. | | 1978 | 401122 |
| effect of sensitization with propionibacterium acnes on the growth of listeria monocytogenes and treponema pallidum in rabbits. | sensitization of rabbits with propionibacterium acnes, a nonspecific stimulant of the reticuloendothelial system, was investigated as a means of enhancing resistance to treponema pallidum. a single i.v. dose of p. acnes given 3 or 7 days before challenge with listeria monocytogenes was capable of suppressing the growth of the heterologous organism, whereas a single i.v. dose 24 hr or 14 days before challenge was not. reactivation via i.v. elicitation with p. acnes 14 days after sensitization (1 ... | 1977 | 401511 |
| effect of bacterial products on inflammatory reactions in the dental pulp. | culture filtrates (extracellular components) and material obtained from disintegrated cells (intracellular components) of cultured plaque bacteria were studied for their capacity to induce inflammatory reactions in the dental pulp. class v cavities were prepared on the buccal surface of 94 teeth: 42 test and 52 control teeth in six adult monkeys. lyophilized bacterial components were sealed into the test cavities either alone or following an 8-h topical application of a solution of the same comp ... | 1977 | 402688 |
| bacteremia after upper gastrointestinal endoscopy. | during 24 months, 200 upper gastrointestinal endoscopies were performed on 193 patients. blood cultures were obtained before and five and 30 minutes after the procedure using thiol (50 ml) and trypticase soy broth (100 ml) media. the mean endoscopic time was 34 minutes. sixteen patients developed bacteremia (8%). twelve groups of microorganisms were detected in positive blood cultures: streptococcus (5 species), lactobacillus sp, veillonella alcalescens, staphylococcus aureus, staph epidermidis, ... | 1977 | 404974 |
| pharmacokinetics of phenytoin and liver cytochrome p-450 levels in mice after single doses of corynebacterium parvum [proceedings]. | | 1979 | 497584 |
| diphtheroid osteomyelitis. | isolates of either corynebacterium diphtheriae or propionibacterium acnes from osteomyelitis are not necessarily contaminants, as shown by the cases of three patients who had bone and joint infections in which these organisms were pathogenic (one in pure culture and two in mixed cultures). previous operation or other factors that compromise host resistance create the setting for these opportunistic organisms. penicillin with or without streptomycin is the treatment of choice, but if penicillin o ... | 1977 | 405396 |
| bacteraemia in asymptomatic human subjects. | | 1977 | 405961 |
| ovarian cancer: use of multiple modality programs involving surgery, radiation therapy and chemotherapy. | appreciating the past reports of effectiveness for various therapeutic modalities in ovarian cancer, the gynecologic oncology group activated eight protocols. three involved epithelial lesions with randomized multimodality trials alone or in combination. the other protocols were devoted to registration of rare tumor case reports. conclusions are still difficult to reach due to inconsistencies in pathologic diagnoses and deficiencies in radiation therapy, chemotherapy and surgery inherent in the ... | 1977 | 406985 |
| effect of the combination of corynebacterium parvum and levamisole on murine tumors. | | 1977 | 413718 |
| is there postdefecation bacteremia? | an investigation was done to determine the incidence of postdefecation bacteremia. a study of 82 healthy volunteers was done. among 164 predefecation cultures, only one (0.6%) from an anaerobic flask was positive for microorganism, which was identified as staphylococcus epidermidis. in only two of 328 (0.6%) postdefecation cultures did microorganisms grow, which were shown to be propionibacterium acnes. the results of this study suggest that either bacteremia after defecation does not occur or i ... | 1979 | 464809 |
| regression of regionally advanced melanoma after arterial infusion with cis-platinum and actinomycin-d. | | 1979 | 466896 |
| macrophage precursors in ovarian carcinoma. | | 1979 | 510998 |
| alterations induced in macrophage and granulocyte-macrophage colony-forming cells by a single injection of mice with corynebacterium parvum. | | 1979 | 513059 |
| [equal sensitivity of normal or tumoral fibroblasts to cytotoxic and cytostatic effects of normal or "corynebacterium parvum" activated peritoneal exudate cells (author's transl)]. | cytotoxic and cytostatic properties of peritoneal exudate cells from balb/c mice either normal or pretreated with corynebacterium parvum normal were studied using as target cells two lines of balb/c fibroblasts one normal (balb) and one transformed by kirsten virus (k.balb).. c. parvum activated cells displayed higher cytotoxic as measured by 51cr or 3h-thymidine release and cytostatic, as measured by 3h-thymidine incorporation, activities against these lines of syngeneic cells. cytotoxic effect ... | 1979 | 475346 |
| an ultrastructural study of peritoneal mononuclear phagocytes from corynebacterium parvum-injected mice. | peritoneal mononuclear phagocytes harvested from mice 24 h after i.p. injection of c. parvum displayed hypertrophy of the golgi and smooth endoplasmic reticulum complex with attendant increase in lysosome production. the ingested bacilli were identified within phagolysosomes, within which large myelin figures accumulated. in addition to heterophagic vacuoles, autophagosomes and lipid droplets were observed. these latter two inclusions may reflect a direct or indirect cytopathic effect of c. parv ... | 1979 | 475974 |
| active, specific immunotherapy of murine leukemia. ii. adjuvant effect of corynebacterium parvum. | we have previously shown that irradiated lstra cells (lx) were immunogenic and could prolong survival of mice bearing lstra tumors. this study demonstrated that addition of corynebacterium parvum to the lx dramatically improved the strength of tumor immunity. in pretreatment-challenge experiments, c. parvum augmented the immunogenicity of 10(6) lx given intradermally, with an optimum dose of 0.14-1.4 microgram c. parvum per mouse. in therapy experiments (intraperitoneal vaccine treatment after t ... | 1979 | 528079 |
| action of cancer chemotherapy-radiotherapy on spleen hypertrophy response to corynebacterium parvum adjuvant therapy. | | 1979 | 536279 |
| inhibition of spontaneous akr leukemia by multiple inoculations of corynebacterium parvum. | in previous studies we have shown that akr mice could be protected from spontaneous leukemia by specific immunotherapy in combination with splenectomy. in this experiment we investigated the effects of nonspecific immunotherapy with c. parvum in a similar regimen. it was found that bi-weekly, ip inoculations of 0.7 mg of c. parvum could significantly protect akr mice from spontaneous tumors, and that splenectomy could not modify this effect. thus, the spleen does not appear to play a determinant ... | 1979 | 476565 |
| effects of intravenous injection of two different strains of corynebacterium parvum in the mouse. | a strain of c. parvum, cn6134, known to have antitumour activity, caused thrombosis in the sites where the organism is phagocytosed. it bound to macrophages in vitro and activated the alternate pathway of complement. a strain of c. parvum, cn5888, which fails to show antitumour activity, did not show thrombosis. it did not bind to macrophages or activate guinea-pig complement. it did, however, cause marrow infarction which seems to result from a diminished clearance of the organism from the circ ... | 1979 | 540104 |
| growth of cutaneous propionibacteria on synthetic medium; growth yields and exoenzyme production. | | 1979 | 541303 |
| enhancement of the thermal response of animal tumors by corynebacterium parvum. | the effect of corynecbacterium parvum treatment on the thermal response of animal tumors was studied. tumors were methylcholanthrene-induced (fsa-ii) and spontaneous (fsa-i) fibrosarcomas in c3hf/sed mice. c. parvum was given i.v. and was followed by local hyperthermia at 43.5 degrees 3 days later. cell survival determined by lung colony assays showed that preadministration of c. parvum insignificantly enhanced the thermal response of both tumors. studies of delay of tumor growth for fsa-ii demo ... | 1979 | 476675 |
| comparison of three methods of susceptibility testing of bacteroidaceae, peptococcaceae and other anaerobes to doxycycline. | the in vitro activity of doxycycline against 147 strains of gram-positive and gram-negative anaerobes was determined by broth dilution, agar dilution and agar diffusion tests. the strains were isolated from clinical specimens in 1977. saccharolytic bacteroides strains (39 b. fragilis, 6 b. thetaiotaomicron, 4 b. vulgatus) showed broth dilution mics of less than or equal to 0.0625-4.0 microgram/ml after 5 h incubation and mics of less than or equal to 16 microgram/ml after 15 h incubation at 37 d ... | 1979 | 543353 |
| [effect of corynebacterium parvum on serum lysozyme (muramidase) levels (author's transl)]. | an i.v. injection of 548 microgram of killed corynebacterium parvum into c57b1 mice leads to significant changes in serum lysozyme (muramidase) levels. after an initial fall at 24 h, the activity of the enzyme increased progressively, reached a peak on the 9th day and returned to control range after the 15th day. | 1979 | 477851 |
| activation of pleural macrophages by intrapleural application of corynebacterium parvum. | a single ipl injection of 0.25 mg cp into cba mice led to accumulation of macrophages in the pleural cavity, but it did not influence res as an injection given iv ipl cp caused a three-to-five-fold increase in the number of nucleated cells in the pleural cavity which persisted at least 14 days. of these cells 86% were macrophages as shown by their esterase activity. less than 30% of cells from the pleural cavity of normal mice were esterase positive. macrophages from the pleural cavity of cp-tre ... | 1979 | 547729 |
| propionibacterium acnes pneumonia in a patient with lymphoma. | a 57 year-old male with lymphocytic lymphoma developed symptoms of cough, fever and progressive dyspnea accompanied by a diffuse lower lung infiltrate. open lung biopsy revealed multiple micro-abscesses surrounding small bronchioles which yielded a pure growth of propionibacterium acnes. | 1979 | 478654 |
| [in vitro sensitivity of corynebacterium acnes (propionibacterium acnes) to meclocycline, clindamycin, erythromycin and neomycin]. | | 1979 | 554810 |
| dual effect of normal and stimulated macrophages and their conditioned media on target cell proliferation. | | 1979 | 480375 |
| [anerobic corynebacteria propionibacterium as immunostimulators and antioncogenic factors]. | | 1977 | 564299 |
| activation of human monocytes by mediators from lymphocytes stimulated with corynebacterium parvum. | human monocytes activated in vitro by lymphokine-containing supernatants of autologous or allogeneic lymphocytes stimulated in vitro by corynebacterium parvum (cp) expressed increased ability to suppress dna-synthesis in a human tumour cell line. monocyte activation was not dependent on in vitro differentiation of monocytes, enhanced cytostatic ability being observed at all stages of in vitro differentiation. the lymphokine-induced cytostatic ability was not affected by intensive washing and try ... | 1979 | 484237 |
| effects of repeated corynebacterium parvum and bcg therapy on immune parameters: a weekly study of melanoma patients ii. changes in serum immunoglobulins and lymphoid cell subpopulations. | two groups, each of eight patients, with metastatic melanoma were immunized with either c. parvum or bcg at 3-weekly intervals. the serum igg, iga, igm levels, e-rosettes, ea-rosetts, sig-bearing cells, 'null cells' and lymphocyte blastogenesis at four pha concentrations were assayed, before immunization and weekly thereafter for 8 weeks. the pre-immunization e-rosette values were significantly reduced, with a significant increase in 'null cell' values and ea-rosette percentages, when compared w ... | 1979 | 487647 |
| metabolic changes following the intravenous infusion of corynebacterium parvum in man. | the acute changes in concentrations of key blood metabolites and liver function tests were measured following intravenous infusion of corynebacterium parvum in 9 healthy patients who had recently undergone resection of a colorectal cancer. the following results were obtained: 1) blood glucose, lactate and ketone body concentrations significantly increased over a 5 hour study period; 2) blood alanine fell during the same period; 3) plasma bilirubin, got and urea were significantly elevated 24 hou ... | 1979 | 445333 |
| effect of 1(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (acnu) on sato lung carcinoma (slc). preliminary result of immunochemotherapy for slc by combination of acnu and propionibacterium acnes. | acnu was highly effective for sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of acnu for slc showed clear dependence upon tumor size. nonspecific activation of host-defence mechanism by propionibacterium acnes contributed to the suppression for the regrowth of solid slc treated by acnu. | 1979 | 450390 |
| c. parvum immuntherapy of transplanted rat tumours. | c.parvum (wellcome cn 6134) has been tested for tumour suppression against a range of syngeneically transplanted rat tumours, both carcinogen-induced and of spontaneous origin. subcutaneous growth was not prevented by distant subcutaneous or intravenous injection of the preparation, although growth rates were sometimes depressed or accelerated. in contrast, c. parvum injected in admixture with tumour cells consistently suppressed their growth and with highly immunogenic tumours induced systemic ... | 1977 | 591131 |
| the reversal of surgically induced reticuloendothelial depression. | the function of the reticuloendothelial (re) system may be depressed by surgical operation. as this system is an important defence mechanism against tumour growth and metastasis, it would be an advantage if this depression could be prevented by the administration of a suitable agent. the agents studied in this case were levamisole, corynebacterium parvum (c. parvum) and glucan. as a measure of re function a carbon clearance test was performed in rats, 1 hr after partial colectomy, animals having ... | 1979 | 487654 |
| [prospects of short-term sequential immunomodulation with levamisole and corynebacterium parvum in neoplastic pathology in the aged]. | | 1979 | 460632 |
| effect of corynebacterium parvum in prevention and reversal of atrophy of the liver following portacaval shunt. | since it has been demonstrated that the administration of corynebacterium parvum is associated with increased hepatocyte proliferation in both normal and regenerating livers, it seemed appropriate to determine whether the use of this agent would affect the hepatic atrophy which occurs following end-to-side portacaval shunts. when administered at shunting, liver weight and liver deoxyribonucleic acid failed to decrease to the same extent as that occurring in untreated, shunted rats. an increase i ... | 1979 | 462347 |
| [immunological problems in cancer]. | | 1977 | 601267 |
| investigations on the bacteriostatic effect of benzoyl peroxide. | | 1979 | 464656 |
| comparative studies on the cell wall composition of some anaerobic coryneforms of varying lympho-reticular stimulatory activity. | anaerobic diphtheroids possessing lympho-reticular stimulatory properties may differ considerably in their peptidoglycan composition. spleen weight-increasing activity of strains directly parallels their antitumour properties. p. granulosum strains, inactive in assays for lympho-reticular stimulation, appear to have a higher cell wall alanine content than most of the p. acnes and p. avidum strains tested. two p. acnes strains, however, had equivalently high alanine ratios and were stimulatory. t ... | 1977 | 608497 |
| studies using labelled c. parvum preparations in mice. | the in vivo distribution of 125i and fluorescein labelled c. parvum, after local and systemic injection mice has been studied. after i.v. injection large amounts were found in the liver, spleen and lungs, with less in the lymph nodes. the distribution after s. c. injection was more restricted; the bulk of inoculum was retained at the injection site and draining lymph node, and only small amounts were found in the liver and spleen. c. parvum was found in bone marrow, but not peritoneal cells afte ... | 1977 | 608498 |
| distribution of technetium-99m labeled corynebacterium parvum in normal and tumor bearing mice. | | 1977 | 608499 |
| distribution of 3h-thymidine-labelled c. parvum in mice. | little is known of the localisation of injected corynebacterium parvum. we therefore developed a method of radiolabelling this vaccine and determined its distribution in the mouse. live c. parvum (wellcome, strain cn 6134) was grown in the presence of 3h-thymidine and subsequently killed by formalin. a high activity, 1-6 x 10(5) cpm/0.1 ml of a 7 mg dry weight/ml concentrated suspension, was obtained. its biological properties (hepatosplenomegaly and antitumour effects) were similar to those of ... | 1977 | 608501 |
| immunotherapy of a murine ovarian carcinoma with corynebacterium parvum and specific heteroantiserum. i. activation of peritoneal cells to mediate antibody-dependent cytotoxicity. | immunotherapy with a combination of corynebacterium parvum and specific heteroantiserum is significantly more effective than treatment with either single agent in prolonging the survival of mice that have recevied an i.p. injection of syngeneic murine ovarian carcinoma (mot) cells. invitro, a combination of c. parvum-activated peritoneal cells and specific heteroantiserum has proven significantly more effective than either single component in destroying 51cr-labeled mot cells in the absence of c ... | 1979 | 489967 |
| chemoimmunotherapy for meningeal melanocytoma of the thoracic spinal cord. report of a case. | | 1979 | 490860 |
| anaerobic bacteria in late infections following orthopedic surgery. | twelve patients with late anaerobic infection following hip or knee arthroplasty or tibia osteosynthesis are presented. peptococci (peptococcus asaccharolyticus, p. magnus, p. prevotii) and peptostreptococci (peptostreptococcus micros, p. anaerobius, p. parvulus) were present in nine of the cases. anaerobic gram-positive or -negative rods were found in three cases (propionibacterium acnes, actinomyces israelii, and bacteroides fragilis). antibodies against the isolated bacteria were detected in ... | 1979 | 492071 |
| [adriamycin-combination chemotherapy with or without immune stimulation by corynebacterium parvum in metastasizing carcinoma of the breast (author's transl)]. | in a randomised, multicentre study the effect of changing the combined cytostatic treatment with vac (vincristin, adriamycin, cyclophosphamide) to fmc (fluorouracil, methotrexate, cyclophosphamide) was tested, as well as the effect of active non-specific immune stimulation with corynebacterium parvum, and compared with a control group. in 59 of 120 patients (49%) in whom the results could be analysed there was a measurable significant regression of tumour size to less than 50% of its initial val ... | 1979 | 510206 |
| potentiation of anamnestic humoral responses by a single intravenous injection of corynebacterium parvum (c. parvum) in adult rabbits. | | 1977 | 608507 |
| effect of corynebacterium parvum on the immune response of the guinea pig to ovalbumin. | | 1977 | 608508 |
| in vitro anti-tumour properties of peritoneal exudate cells of conventional germ-free and stimulated mice. | adherent cells of peritoneal exudates were obtained from conventional, or from germ-free mice or from mice having received in intraperitoneal infection of a variety of phlogogenic substances such as corynebacterium parvum (c. parvum) (mérieux) 500 microgram, thioglycolate (difco) 3 ml, bayol (esso) 0.50 ml + 0.50 ml culture medium, glycogene 1.2 ml. the cytotoxic properties adherent cells were studied in vitro by the chromium release technique (crt) and their cytostatic properties by the inhibit ... | 1977 | 608509 |
| chemical and biological properties of a purified lymphoreticular-stimulating fraction of corynebacterium parvum (propionibacterium acnes type i). | a method is described in which washed whole cells of corynebacterium parvum were chemically and enzymatically extracted to remove cytoplasm and cell-wall lipids. the resultant insoluble cell-wall residue possessed lympho-reticular stimulating properties as measured by their ability to increase spleen weight and protect against tumour-cell challenge. analysis of the final product by chromatography and infrared spectroscopy has shown it to consist of carbohydrate and peptidoglycan, both of which a ... | 1979 | 513108 |
| the facilitation of tumour growth in the lung by cyclophosphamide in artificial and spontaneous metastases models. | | 1979 | 527634 |
| biotyping of propionibacterium acnes isolated from normal human facial skin. | biochemical and serological characteristics of 128 strains of propionibacterium acnes isolated from the facial skin of healthy japanese volunteers were compared with the three standard strains of the american type culture collection, atcc 6919, 11827, and 11828. accordingly, the isolated strains of p. acnes were classified into five biotypes (b1 to b5) on the basis of fermentation tests of ribose, erythritol, and sorbitol. two serotypes were distinguished by the agglutination test. p. acnes belo ... | 1979 | 539817 |
| in vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with c. parvum. | we have investigated whether peritoneal exudate cells (pec) from c. parvum (cp) treated (c3hf/bu mice could transfer in vivo the resistance against a syngeneic fibrosarcoma (fsa). inhibition of tumour development and prolongation of survival of recipients were observed when cp-activated pec were admixed with fsa cells before their intraperitoneal (ip) or subcutaneous (sc) injections into normal mice. the antitumour activity increased with the increase of the ratio of effector to target cells. he ... | 1977 | 608514 |
| effects of c. parvum on radiation response of murine tumors. | the effects of intravenous c. parvum (cp) on the efficacy of fractionated gamma-irradiation in treating a fairly immunogenic fibrosarcoma (fsa) and a weakly immunogenic mammary carcinoma (mdah-mca-4) were studied in c3hf/bu mice. tumors were 8 mm in diameter at the start of irradiation. the fsa was exposed to 500 and the mdah-mca-4 to 750 rads daily for 3.6 or 10 days. the administration of 0.25 mg cp varied from 4 days before to 14 days after the start of irradiation. cp greatly augmented radio ... | 1977 | 608515 |
| chemo-immunotherapy of mouse tumours using cyclophosphamide and c. parvum. | treatment of a chemically induced mouse solid fibrosarcoma using either non-specific (c. parvum 350 mu i.v.), or specific active (s.c. c. parvum mixed with 5.10(5) irradiated tumour cells) immunotherapy, 4 days after a single dose of cyclophosphamide (200 mg/kg) was synergistically more effective than either c. parvum or drug treatment alone. a contributory factor may be that cyclophosphamide pretreatment has been shown to potentiate the specific antitumour immunity that arises from c. parvum in ... | 1977 | 608516 |
| increased sensitivity of c. parvum treated mice to ionizing whole body irradiation. | we have investigated whether c. parvum (cp)-induced stimulation of hematopoiesis affects the survival of mice exposed to the whole body irradiation (wbi). c3hf/bu mice treated with cp exhibit an increased hematopoietic colony forming activity in their spleens and blood, but not in their bone marrow, as determined by the exogenous spleen colony assay. also, cp-treated c3hf/bu as well as cba mice show an increase in their endogenous colonies. this increased hematopoietic activity caused by cp trea ... | 1977 | 608517 |
| experimental evaluation of nonspecific immunostimulation and chemotherapy in the intracranial tumor-bearing fisher rat. | one hundred sixty rats bearing intracranial tumors were divided into groups of 10 to evaluate c-i interval +, effect of chemotherapy alone (bcnu), chemotherapy and c. parvum, and c. parvum alone in the rat tumor model. all therapy was administered intraperitoneally: bcnu -5.2 mg/kg (40% of ld10) on the 9th and 16th post tumor implant day, and c. parvum-1.4 mg regardless of the body weight and the 6th or 23rd day and 6th and 23rd post tumor implant day. an additional group received bcnu on the 9t ... | 1977 | 608518 |
| the effect of pretreatment with corynebacterium parvum on the growth of a chemical induced transplanted murine tumor. | unspecific immunostimulation with or without specific tumor immunotherapy may well contribute to the control of minimal residual cancer. corynebacterium parvum (c.p.) has been shown to raise the level of immunocompetence in tumor bearing animals. experiments are reported, which aim at an evaluation of optimal conditions for an immunostimulation with c.p. prior to the transplantation of balb/c meth a ascitis. using different dosages, routes of injection and schedules of vaccination it was found, ... | 1977 | 608519 |
| prolonged effect of corynebacterium parvum stimulation on granulopoiesis. | an intravenous injection of 548 microgram of killed corynebacterium parvum (c. parvum) into c57bl mice led to a significant increase in the number of both committed stem cells (gm-cfc) and proliferating cells of bone marrow granulocytic series. this increase appeared 24 h after the injection of the bacterium, persisted in varying levels until the 4th week and was accompanied by a marked and prolonged granulocytosis. the proportion of gm-cfc in dna synthesis was found to be increased 1, 2, and 5 ... | 1979 | 542797 |
| the local effect of intravesical corynebacterium parvum in the dog. a preliminary study. | high doses of c. parvum introduced in the bladder of the dog provoke changes in the submucosa. the significance and importance of these modifications should be investigated. | 1977 | 608526 |
| comparison of bcg and c. parvum preparations for adjuvant contact therapy of a rat sarcoma. | | 1977 | 608529 |
| histological changes of intravascular coagulation in mice resulting from intravenous injection of c. parvum. | a histological study was made of liver and other tissues of mice at intervals after injection of c. parvum. as early as 20 min after injection occasional thrombi surrounded by polymorphs were seen in the alveolar capillaries. a general thrombosis rapidly developed in the hepatic vessels with consequent hepatic necrosis. thrombi also developed in splenic vessels. this intravascular coagulation was prolonged, lasting at least 7 days. there was evidence that fresh thrombi were being formed througho ... | 1977 | 608532 |
| effects of corynebacterium parvum vaccine on drug metabolism in the mouse. | mice of the cba strain were given a single intraperitoneal injection of c. parvum vaccine at 50 mg/m2. there followed a progressive increase in liver weight and in the duration of hexobarbitone sleeping time, accompanied by a marked decrease in liver microsomal protein and in cytochrome p-450/mg microsomal protein. that is to say, content of cytochrome p-450 was reduced out of proportion to the apparent loss of endoplasmic reticulum. these changes were paralleled by decreases in microsomal o-dem ... | 1977 | 608533 |
| effects of bcg and corynebacterium parvum on immune reactivity in melanoma patients. | sixteen patients with disseminated melanoma were immunised with either bcg (8 cases) or c. parvum (8 cases) on three occasions at 21 day intervals. blood for assay was taken immediately before the first immunisation and weekly for eight weeks thereafter. total white count tended to increase but little change was seen in lymphocyte and monocyte counts. serum igg increased after bcg but not with c. parvum, serum iga and igm did not alter. the 'e' rosette % did show some increase mainly after c. pa ... | 1977 | 608536 |