| randomized trial in advanced breast cancer using combination chemotherapy with or without c. parvum; preliminary results. | in a prospectively randomized cooperative study patients with metastatic breast cancer were treated with or without corynebacterium parvum (c.p.)5 mg/sc/m2 on day 1 in addition to cao/cmf (cyclophosphamid (c) 150 mg/m2/d per os x 5 d and adriamycine (a) 50 mg/m2 i.v. d 1 and oncovin (o) 1.0 mg/m2 i.v. d 1. 6 cao-cycles q 28 days later were followed by monthly cmf cycles q 28 d with cyclophosphamide (same dose), methotrexate 30 mg/m2 i.v. 1 and 5-fluorouracil 600 mg/m2 i.v. d 1). 76 patients ente ... | 1977 | 344108 |
| c. parvum clinical protocols: prototypes and summary results in u. s. trials with wellcome coparvax. | clinical investigations utilizing wellcome c. parvum in cancer therapy number more than one hundred in multiple institutions. multiple diseases in various stages are being attacked by multi-modality therapy, making the role of immunotherapy very difficult to assess. fundamental laboratory observations have suggested ways of weaving non-specific with specific immunotherapy, and these with chemotherapy and radiation to yield maximum therapeutic benefit. current protocols include examples of the cr ... | 1977 | 344109 |
| clinical immunotherapy experiences in the southeastern cancer study group. | the southeastern cancer study group has been particularly interested in the use of immunological adjuvants in the treatment of melanoma and acute myelogenous leukemia. a study of chemotherapy versus chemoimmunotherapy in randomly selected patients with metastatic malignant melanoma revealed no significant increase in either complete remissions or overall survival in the group receiving chemoimmunotherapy. preliminary results in a study involving maintenance of patients with acute myelogenous leu ... | 1977 | 344110 |
| immunotherapy from malignant disease. | | 1978 | 348035 |
| some examples of interactions between drugs in cancer chemotherapy. | drug combinations in cancer treatment are widely utilized because they frequently result in better therapeutic activity than the single treatments. the mechanism(s) by which this can be achieved may reside in an enhanced chemotherapeutic effect or in reduced toxicity, it being difficult to dissociate the two aspects. to underline this difficulty, experimental studies will be reported. a first example illustrates the interaction between phenobarbital and cyclophosphamide. depending on the schedul ... | 1978 | 348085 |
| combination chemotherapy plus methanol extracted residue of bacillus calmette-guérin or corynebacterium parvum in stage iii lung cancer. | seventy-six patients with stage iii bronchogenic carcinoma were treated with monthly adriamycin, cyclophosphamide, cis-dichlorodiammineplatinum(ii), and vincristine. in addition, they were randomized to receive either no immunotherapy, the methanol extracted residue of bacillus calmette-guérin (mer), or corynebacterium parvum (c. parvum). age, histology, extent of disease, prior therapy, and performance status were comparable in the three treatment groups. twelve patients (16%) died having recei ... | 1978 | 350388 |
| chemo-immunotherapy for unresectable bronchogenic carcinoma. | seventy-nine patients with metastatic or unresectable bronchogenic carcinoma were treated with a regimen of combination chemotherapy which included methotrexate, oncovin (vincristine), cyclophosphamide, and adriamycin (moca), and were randomized to receive no additional therapy, immunotherapy with bacillus calmette-guérin, or immunotherapy with corynebacterium parvum (c. parvum). the response rate and estimated median survival time were 68% and 42 weeks in small cell carcinoma and 18% and 29 wee ... | 1978 | 350397 |
| effectiveness of topically applied antibiotics on anaerobic bacteria in the pilo-sebaceous duct. | an unspecific cream vehicle containing 1% erythromycin base was applied once a day for 10 days to one side of the forehead of 16 healthy subjects and the same vehicle without the active agent to the other side. using the same procedure a solution containing 1.19% clindamycin phosphate (corresponding to 1% clindamycin base) and the corresponding unspecific vehicle was administered to another group of 17 healthy males. prior to the treatment and after the end bacteria were obtained from the pilose ... | 1978 | 352763 |
| immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. i. use of bacterial adjuvants in induction of immunity demonstrable in winn tests. | | 1978 | 354799 |
| combination chemoimmunotherapy for extensive non-oat cell lung cancer. | in a prospective randomized trial, sc corynebacterium parvum (c. parvum) immunotherapy did not significantly affect the responses and survival of 49 non-oat cell lung cancer patients receiving isophosphamide and adriamycin chemotherapy. remissions (tumor regression greater than 50%) were seen in five of 23 patients receiving an intensive c. parvum schedule and in three of 26 patients receiving a nonintensive c. parvum schedule (22% versus 12%). median survival was 20 weeks for patients given int ... | 1978 | 356968 |
| the effect of intramural injection of immunotherapeutic agents on bladder histology and systemic humoral response. | bacillus calmette-guerín (bcg), corynebacterium parvum, and various mycobacterium fragments were injected intramurally into mouse bladders and the resulting systemic humoral stimulation and local histologic reactions were evaluated. c. parvum and methanol extracted residue of bcg elicited significant immunostimulation without producing irreversible bladder damage. the severe histologic disruption caused by bcg could be reduced by the antituberculus drug isoniazed without abrogating the humoral s ... | 1978 | 361626 |
| [immuno-chemotherapy in patients with disseminated metastasizing stage iii melanoma. randomized study with methyl-ccnu versus c. parvum plus methyl-ccnu]. | 34 patients with disseminated malignant melanoma (stage iii) were randomized to the following therapy groups: chemotherapy (meccnu, nsc 99441; 200 mg/m2, given orally every 8 weeks), or immuno-chemotherapy (1 mg corynebacterium parvum i.v., on days 1-4 + meccnu 200 mg/m2 on day 8, repeated every 7 weeks). total therapy response rate was 33%; total and partial remissions were achieved in 26% of the patients receiving chemotherapy, and in 40% under immuno-chemotherapy. interim life table analysis ... | 1978 | 362293 |
| multimodal immunotherapy of primary gastrointestinal tumors in rats. 1. histologic correlation. | the effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. multimodal immune manipulation consisted of combinations of splenectomy, c. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. such immunologic intervention resulted in significant inhibition of tumor growth, and their metastasis. ten of 10 untreated rats, 8 of 8 rats treated with splenectomy alone and 10 of 10 rats treated with nor ... | 1978 | 363250 |
| immunomodulation by corynebacterium parvum. 1. variable effects on anti-sheep erythrocyte antibody responses. | corynebacterium parvum injected i.p. 1--16 days prior to i.p. antigen inoculation virtually abolished both igm and igg primary responses to 1 x 10(8) srbc. the suppression was significantly marked at antigen doses ranging from 1 x 10(6)--1 x 10(9) srbc but not at 5 x 10(9) srbc. as little as 56 microgram c. parvum caused a marked suppression of the response to 1 x 10(8) srbc. in secondary responses c. parvum given either one day before priming with 1 x 10(8) srbc or one day before secondary chal ... | 1978 | 363603 |
| evaluation of routine subcultures of macroscopically negative blood cultures for detection of anaerobes. | routine anaerobic subcultures of macroscopically negative blood culture bottles, performed within 1 day of receipt of the culture and after 5 days of incubation, were evaluated. anaerobes were recovered from 207 (12.3%) of the total 1,688 positive cultures and, of these, 154 were only detected macroscopically, 11 only by subculture, and 42 by both procedures. in no instance was the anaerobe detected earlier with the subculture, and the time required for a definitive identification was reduced fo ... | 1978 | 363740 |
| [quality of nutrient media according to indices of the cultivation process]. | | 1978 | 364893 |
| cocarcinogenesis. | | 1979 | 367444 |
| [current status of immunotherapy of malignant tumors]. | | 1979 | 367730 |
| immunotherapy of solid tumor. | | 1979 | 375448 |
| defective tumoricidal capacity of macrophages from a/j mice. i. characterization of the macrophage cytotoxic defect after in vivo and in vitro activation stimuli. | macrophages from a/j mice fail to develop tumoricidal activity after any of several in vivo or in vitro treatments that activate cells from c3h/hen mice. peritoneal macrophages from a/j mice treated i.p. with viable mycobacterium bovis, strain bcg, killed corynebacterium parvum, or pyran copolymer fail to develop in vitro tumoricidal activity; varying the numbers of macrophages from treated mice added to target cells, or the dose and time of treatment, or the treatment schedule of these in vivo ... | 1979 | 376720 |
| in vitro killing of schistosomula of schistosoma mansoni by bcg and c. parvum-activated macrophages. | resistance to schistosoma mansoni infection in the mouse has been induced either specifically by a primary infection with this parasite or nonspecifically by a variety of immunostimulants such as bcg. in the present study we developed an in vitro system to examine the effector mechanism of nonspecifically induced resistance. activated macrophage monolayers obtained from bcg- or corynebacterium parvum treated mice killed a respective mean 32 +/- 6% and 48 +/- 5% of schistosomula after 24 hr incub ... | 1979 | 376723 |
| current state of clinical immunotherapy. | | 1979 | 377611 |
| effect of adriamycin and corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. | administration of adriamycin and corynebacterium parvum alone in c57bl/6j mice bearing lewis lung carcinoma stimulated the direct (19s) and indirect (7s) plaque-forming cell (pfc) response specific for sheep red blood cells. thus adriamycin appears to possess some immunostimulatory effect on tumor-bearing mice with much less effect than c. parvum alone. simultaneous administration of adriamycin and c. parvum decreased the pfc response compared to that for c. parvum alone. this decrease may indic ... | 1979 | 379400 |
| corynebacterium parvum: effects on the biochemistry of mouse serum and liver. | | 1979 | 379402 |
| subcutaneous corynebacterium parvum in bladder cancer: a controlled study of its immunological effects. | fourteen out of 26 patients with invasive bladder cancer were randomly assigned to receive weekly subcutaneous injections of corynebacterium parvum (cp) in addition to standard treatment. peripheral blood t lymphocyte percentage, k cell activity, mitogen responsiveness, and monocyte and polymorph leucotaxis were measured at intervals over a period of 1 to 2 years. the only consistent difference between the cp-treatment patients and the controls was a slightly higher level of k cell activity in t ... | 1979 | 380732 |
| cyclophosphamide plus 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (dtic) with or without corynebacterium parvum in metastatic malignant melanoma. | one hundred twenty patients with metastatic malignant melanoma were randomized to receive either cyclophosphamide, 600 mg/m2 iv, on day 1 plus dtic 200 mg/m2 iv days 1 through 5, or the same chemotherapy plus c. parvum 5 mg/m2 iv on day 8 and day 15. therapy was repeated every 21 days. although responses were observed in 13.8% of patients on cyclophosphamide plus dtic versus 25.5% of patients on cyclophosphamide plus dtic plus c. parvum, the median duration of remission was 15.6 weeks on chemoth ... | 1979 | 383276 |
| c. parvum treatment of transplanted rat tumours of spontaneous origin. | c. parvum (wellcome cn6134) has been examined for suppression of a range of transplanted rat tumours of spontaneous origin. with five tumours (three mammary carcinomas and two fibrosarcomas) growth of comparatively high cell inocula (with respect to the minimum for growth in control rats) was suppressed by admixture with the vaccine. equivalent dry weights of glaxo, pasteur or connaught bcgs were relatively ineffective. intralesional injection of c. parvum into three three established tumours (t ... | 1979 | 385514 |
| direct effects of corynebacterium parvum and bcg on human monocyte-mediated tumour cell cytostasis in vitro. | four strains of corynebacterium parvum (cp) and bcg induced low levels of cytostatic ability to a human tumour cell line in human monocytes when added directly to conventional monocyte cultures. the cytostatic ability induced by mediators from autologous lymphocytes stimulated with the same agents was greater than that produced by direct addition to monocytes. bcg was more efficient in stimulating lymphocyte dna-synthesis and lymphokine release than any of the cp strains tested. in order to test ... | 1979 | 386712 |
| prostaglandin-like substances in propionibacterium acnes. iii. differential contractile effects on smooth muscle layers of the human utero-tubal junction. | the biological activity of a lipid fraction extracted from p. acnes was tested on isolated smooth muscle strips from the human utero-tubal junction. the bioassay experiments support the concept that prostaglandin-like substances (pls) occur in p. acnes. however, in the bioassay system used, the effect of pls was different from that of pgf2 alpha and pgi2 but similar, although not identical, to that of arachidonic acid and pge2. | 1979 | 387431 |
| [protection of mice with bacterial phospholipids against the lethal effect of frog virus 3 (fv 3) (author's transl)]. | a bacterial phospholipid extract (ebp) inoculated intraveinously at a dose of 1 mg/25 g body weight 30 hours before infection protects mice against the lethal effect of frog virus 3 (fv 3). the anti-fv 3 resistance produced by ebp requires protein synthesis during the period of pretreatment. the treatment with the bacterial extract has no effect on the inhibition of the macromolecular synthesis of the liver (rna and dna) which is observed at the beginning of the infection. however 48 hours after ... | 1979 | 388298 |
| the prevalence of anaerobic bacteria in suprapubic bladder aspirates obtained from pregnant women. | the incidence of asymptomatic bacteriuria due to aerobic, facultative anaerobic and strictly anaerobic bacteria during pregnancy was determined in 185 patients admitted for complications of pregnancy, using suprapubic bladder aspiration. anaerobic bacterial counts of 103 per ml urine or higher were detected in 6.4 per cent of the specimens. the incidence of anaerobic bacteriuria seems comparable to that of bacteriuria due to aerobic and facultative anaerobic micro organisms. in our group of pati ... | 1979 | 388942 |
| the effect of bcg-vaccination on vaccinia virus infections in mice. | pretreatment with bcg yielded a high degree of protection against experimental vaccinia virus infections in mice. corynebacterium parvum and aristolochia acid were less protective; other immunostimulants were ineffective. | 1979 | 389657 |
| the effect of acidic polysaccharides and prostaglandin-like substances isolated from propionibacterium acnes on granulocyte chemotaxis. | three acidic polysaccharide (ap) fractions and the prostaglandin-like substances (pls) isolated from p. acnes were investigated regarding their chemotactic activities on polymorphonuclear leukocytes. both ap's and pls induced a significant chemotatic response, which suggests their involvement in inflammatory acne vulgaris. | 1979 | 391585 |
| chemoimmunotherapy (dtic and corynebacterium parvum) as adjuvant treatment in malignant melanoma. | sixty-one patients with stage i or ii (lymph node involvement) malignant melanoma were prospectively randomized into a control group receiving surgical treatment only (consisting of wide excision of primary and regional node dissection) and a group receiving the same surgical treatment plus adjuvant therapy with dtic and corynebacterium parvum. followup times ranged from 1 1/2 to 4 years. among the 29 patients in the surgical control group, there were five hematogenous recurrences and one region ... | 1979 | 393377 |
| immunotherapy of lung cancer. i. review of clinical trials in non-small cell histologic types. | | 1979 | 394836 |
| antitumor activity of cell-wall skeleton of propionibacterium acnes c7 in mice and guinea pigs. | the antitumor activity of the cell-wall skeleton (cws) of propionibacterium acnes c7 was examined by using transplantable tumors in syngeneic mice and in guinea pigs, and autochthonous tumors in mice. p. acnes-cws was shown to suppress the growth of fibrosarcomas, el4 leukemia, and mh134 hepatoma in syngeneic mice, and to regress the established tumors of a fibrosarcoma (mc104) in c57bl/6j mice, and a hepatoma (line-10) in strain-2 guinea pigs. the oil-attached p. acnes-cws mixed with fructose m ... | 1979 | 395008 |
| human monocyte-mediated cytotoxicity to k-562 cells: activation by lymphokines. | human monocytes purified by adherence and prolonged in vitro monolayer culture were activated by supernatants of autologous lymphocytes stimulated with live bacillus calmette-guérin or killed corynebacterium parvum. activated monocytes expressed increased ability to lyse k-562 cells prelabelled with methyl-3h-thymidine in a 48 h assay. activation could be detected at a 1:64 dilution of lymphokine supernatants. target cell killing by activated monocytes was strongly influenced by the density of t ... | 1979 | 396667 |
| influence of tumor burden, tumor removal, immune stimulation, plasmapheresis on monocyte mobilization in cancer patients. | | 1979 | 397757 |
| immune response modulation by colonization of germfree rats with propionibacterium acnes. | propionibacterium acnes (oral and/or parenteral administration) had a modulating effect on antibody-and cell-mediated immune responses of germfree (gf) and monoassociated (ma) rats. in conventionally reared rodents, parenteral injection of killed p. acnes stimulated the splenic plaque-forming cell response to sheep erythrocytes. however, in gf rats and in rats monoassociated with viable p. acnes, parenteral injection of killed p. acnes antigen inhibited the plaque-forming cell response to sheep ... | 1979 | 397928 |
| phagosome/lysosome fusion: a possible prerequisite for the enhancement of antibody responses in vitro by bcg, mycobacterium leprae and corynebacterium parvum. | primary in vitro antibody responses to srbc were suppressed in cultures prepared from the spleens of cba mice injected i.v. 20 days previously with 10(8) liver bcg. in contrast, cultures prepared from mice injected with dead bcg showed enhanced responses. in vitro spleen cell responses of the mice had returned to normal levels 4--6 weeks after their injection, but if dead bcg, m. leprae or c. parvum was added to the cultures, responses were enhanced. the enhancing effect of the added bacteria co ... | 1979 | 399339 |
| adjuvant immunotherapy. | because systemic spread occurs early in the growth of many malignancies, control of occult micrometastases must be an integral part of cancer treatment. for this reason, surgery and radiation therapy alone may fail to achieve a cure despite eradication of the primary tumor. chemotherapy is potent and systemic in its effects but kills tumor cells by first-order kinetics so the last cancer cell may not be eliminated. an agent is needed that can selectively attack and destroy small numbers of tumor ... | 1978 | 399764 |
| [technics for isolation, incubation and preliminary identification tests]. | in this report the aa. emphasize the fact that anaerobes are mostly isolated from mixed cultures in which several bacteria are present. therefore they suggest to grow all the bacteria under the best conditions and consequently to select the anaerobes from the aerobes. furthermore they describe the selecting techniques used at istituto superiore di sanità and clinica medica iii, to attain this aim and enumerate the best methods used for anaerobic incubation. | 1979 | 399835 |
| adjuvant intralesional and systemic corynebacterium parvum immunotherapy for surgically treated head and neck cancer. | | 1978 | 401122 |
| effect of sensitization with propionibacterium acnes on the growth of listeria monocytogenes and treponema pallidum in rabbits. | sensitization of rabbits with propionibacterium acnes, a nonspecific stimulant of the reticuloendothelial system, was investigated as a means of enhancing resistance to treponema pallidum. a single i.v. dose of p. acnes given 3 or 7 days before challenge with listeria monocytogenes was capable of suppressing the growth of the heterologous organism, whereas a single i.v. dose 24 hr or 14 days before challenge was not. reactivation via i.v. elicitation with p. acnes 14 days after sensitization (1 ... | 1977 | 401511 |
| a special report: four-year study of a boy with combined immune deficiency maintained in strict reverse isolation from birth. | a 4-year study of a boy with combined immune deficiency is presented, and the impact of this disease on various aspects of his growth and development is examined. there is no evidence of immune deficiency in either parent or in the genetic background on the maternal side. three children of a brother of the mother's father may have had immune deficiencies but two have grown to be teenagers with no problems. another died. at autopsy, however, lymph nodes appeared normal. the deceased older brother ... | 1977 | 401538 |
| effect of bacterial products on inflammatory reactions in the dental pulp. | culture filtrates (extracellular components) and material obtained from disintegrated cells (intracellular components) of cultured plaque bacteria were studied for their capacity to induce inflammatory reactions in the dental pulp. class v cavities were prepared on the buccal surface of 94 teeth: 42 test and 52 control teeth in six adult monkeys. lyophilized bacterial components were sealed into the test cavities either alone or following an 8-h topical application of a solution of the same comp ... | 1977 | 402688 |
| antitumor activity of a brucella abortus preparation. | mice injected intraperitoneally with sarcoma-180 cells develop ascites and eventually die. intraperitoneal injection of a nonviable, aqueous... ether-extracted brucella abortus preparation (bru-pel) as early as 7 days before or as late as 7 days after injection of tumor cells significantly inhibited development of ascites and protected against death. bru-pel was not effective if injected after ascites was grossly apparent. bru-pel was significantly more active than a corynebacterium parvum prepa ... | 1977 | 404249 |
| bacteremia after upper gastrointestinal endoscopy. | during 24 months, 200 upper gastrointestinal endoscopies were performed on 193 patients. blood cultures were obtained before and five and 30 minutes after the procedure using thiol (50 ml) and trypticase soy broth (100 ml) media. the mean endoscopic time was 34 minutes. sixteen patients developed bacteremia (8%). twelve groups of microorganisms were detected in positive blood cultures: streptococcus (5 species), lactobacillus sp, veillonella alcalescens, staphylococcus aureus, staph epidermidis, ... | 1977 | 404974 |
| diphtheroid osteomyelitis. | isolates of either corynebacterium diphtheriae or propionibacterium acnes from osteomyelitis are not necessarily contaminants, as shown by the cases of three patients who had bone and joint infections in which these organisms were pathogenic (one in pure culture and two in mixed cultures). previous operation or other factors that compromise host resistance create the setting for these opportunistic organisms. penicillin with or without streptomycin is the treatment of choice, but if penicillin o ... | 1977 | 405396 |
| bacteraemia in asymptomatic human subjects. | | 1977 | 405961 |
| [radioprotection conferred by corynebacterium parvum against the lethality caused by x irradiation at sublethal and lethal doses in the mouse]. | intraperitoneal injection of corynebacterium parvum (c. parvum) into balb/c mice produces a protection against toxicity or lethality provoked by ionizing radiation (750 r and 950 r). survivals reaching nearly 90 days have been recorded. | 1977 | 406088 |
| ovarian cancer: use of multiple modality programs involving surgery, radiation therapy and chemotherapy. | appreciating the past reports of effectiveness for various therapeutic modalities in ovarian cancer, the gynecologic oncology group activated eight protocols. three involved epithelial lesions with randomized multimodality trials alone or in combination. the other protocols were devoted to registration of rare tumor case reports. conclusions are still difficult to reach due to inconsistencies in pathologic diagnoses and deficiencies in radiation therapy, chemotherapy and surgery inherent in the ... | 1977 | 406985 |
| antitumor activity of propionibacterium acnes (corynebacterium parvum) and isolated cytoplasmic fractions. | the tumor-inhibitory effect of an intralesional injection of propionibacterium acnes was of limited duration ("finite"). our model was the dba/2 syngeneic mouse injected with p815 mastocytoma cells (5 x 10(5)) into each rear footpad; only the left was treated, leaving the right as a "pseudometastasis." the finite effect occurred at approximately 21 days after the first treatment. subsequent i.p. treatments with p. acnes did not alter this effect, although they increased mean survival time. with ... | 1977 | 409491 |
| reticulostimulating properties of killed vaccines of anaerobic coryneforms and other organisms. | vaccines prepared from 115 strains of anaerobic coryneforms and other organisms were tested in mice for their reticulostimulating ability as judged by the degree of spleen hypertrophy produced after ip injection. almost all vaccines caused a statistically significant increase in spleen weight, but the ability to produce spleen ratios (test mean wt:control mean wt) of 4 or more was confined to propionibacterium acnes and p. avidum strains. p. acnes, type ii, gave high spleen ratios more frequentl ... | 1977 | 411938 |
| effect of the combination of corynebacterium parvum and levamisole on murine tumors. | | 1977 | 413718 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. v. comparison of the effects of tilorone hydrochloride, levamisole, methanol-soluble fraction of mycobacterium butyricum, bcg, and a nonviable aqueous ether extract of brucella abortus preparation in treatment of mice with tumors. | | 1978 | 413929 |
| effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. comparative studies in normal and congenitally athymic (nude) mice. | clinically, it is important to know whether agents used for immunostimulation require the presence of functional thymus-derived (t) cells. previous studies showed that both bcg and c. parvum induced a macrophage-dependent enhanced in vivo listeria clearance and in vivo inhibition of a fibrosarcoma induced by 20-methylcholanthrene. these two models were re-evaluated in congenitally thymusless (nude or nu/nu) b10lp mice lacking functional t cells. in nu/nu mice, (1) bcg failed to enhance listeria ... | 1977 | 415917 |
| the effect of corynebacterium parvum on the proliferation of monocyte precursors in the bone marrow of mice. | the anti-tumour activity of c. parvum is thought to be mediated via the monocyte/macrophage system (scott, 1974). these cells originate from rapidly dividing precursors in the bone marrow and it might be at this level that c. parvum exerts its action. to test this hypothesis bone marrow t0 swiss mice has been cultured according to the method of bradley and metcalf (1966), which gives an index of the number of proliferating macrophage precursor cells at the time of sacrifice. experiments were set ... | 1977 | 415919 |
| conditions favouring the selection of either specific or non specific c. parvum-mediated, systemic antitumour immunity in mice. | accumulated data suggest that one of two antitumour mechanisms of c. parvum may predominate depending on the route of injection of c. parvum and its distribution in relation to the tumour. after systemic c. parvum the mechanism is considered to be immunologically non specific (i.e. not requiring tumour specific antigens) and mediated by c. parvum activated macrophages. after local injection of c. parvum the interaction (direct or lymph node mediated) between c. parvum and tumour specific antigen ... | 1977 | 415921 |
| proposals for quality control methods of bacterial vaccines for immunostimulation. iii. effect of bcg and c. parvum on in vivo listeria clearance and tumor growth. | two quality control methods for bcg and c. parvum are described. first, in vivo macrophage dependent-spleen clearance of listeria monocytogenes in inbred b10lp mice. bcg and c. parvum were administered intravenously prior to listeria inoculation (a prophylactic model). conditions for enhanced listeria clearance including dose, route and time interval were described for each vaccine. next, a tumor model was developed: i.e. a fibrosarcoma, chemically induced by 20-methylcholanthrene in inbred balb ... | 1977 | 415924 |
| fatty acids of gram-positive bacterial rods from human dental plaque. | | 1978 | 416814 |
| [potentiation of immunologic memory by corynebacterium parvum and its mechanism]. | immune response to bovine serum albumin (bsa) at dose of 2,50 mg/kg which is rather a weak immunogen in rabbits, when given intravenous was highly potentiated when the animals received a previous single intravenous infection of 2 mg/kg of c. parvum, followed by subsequent bsa anamnestic challenges for several months. thus, the antibody amounts synthesized following the 1st anamnestic injection (3 weeks) were 0,260 mg/ml in the control versus, 0,800 mg/ml in the c. parvum pretreated groups; follo ... | 1977 | 417841 |
| natural killer cells may be the only cells in normal mouse lymphoid cell populations endowed with cytolytic ability for antibody-coated tumour target cells. | mouse normal lymphoid cells were analysed as to their ability to perform in three cytolytic systems: ability to act as 'natural killer', nk, cells against a nk sensitive tumour target, yac; as effector cells against igg-coated 815 cells, or to function as effector cells against igg-coated crbc. nk activity and adcc against the igg-coated p815 cells were found to vary in parallel as affected by age, organ distribution and genotype of the effector cells. on the other hand, adcc against crbc was la ... | 1978 | 418499 |
| further observations on the inhibition of tumor growth by c. parvum with cyclophosphamide. vii. effect of treatment prior to primary tumor removal on the growth of distant tumor. | the present investigations were directed toward determining whether primary tumor manipulation prior to its removal is advantageous for the control of metastases and survival. studies were carried out to ascertain whether 1) there is justification for delaying surgical removal of a primary tumor to permit preoperative administration of cyclophosphamide (cy) and/or c. parvum (cp) and 2) there is an advantage to administering the immunotherapy directly into a primary tumor. after operation, in all ... | 1979 | 421172 |
| effect of corynebacterium parvum on liver proliferation and regeneration. | | 1979 | 421219 |
| the aerobic growth of propionibacterium acnes in primary cultures from skin. | although propionibacterium acnes ordinarily grows as an anaerobe, this organism was commonly seen on aerobic primary cultures (directly from skin) of the forehead, axilla, deltoid area, and antecubital fossa. on subculture, strains from aerobic primary cultures showed their normal anaerobic state. on repeated tests of the foreheads of 7 subjects over periods of 1 to 4 yr, 24% of all cultures were positive for propionibacteria (p. acnes) on aerobic culture. this phenomenon was equally common in c ... | 1979 | 422866 |
| [n-alkane oxidation by propionic acid bacteria]. | propionic acid bacteria were found for the first time to be capable of oxidizing n-alkanes. the value of qo2 is higher on a mixture of n-alkanes (c12--c20) than on individual hydrocarbons whose availability is determined by the length of a hydrocarbon chain: c15 and c16-alkanes are oxidized best of all; c14, c13 and c12-alkanes are oxidized at a lower rate; and alkanes whose chain comprises less than ten carbon atoms are not oxidized at all. hexadecane is oxidized to co2, cetyl alcohol and palmi ... | 1979 | 423808 |
| skin and soft tissue polymicrobial infections from intravenous abuse of drugs. | skin and soft tissue infections were studied in 21 seriously ill narcotic addicts who had been admitted to hospital. subcutaneous abscesses were present in 14 patients; cellulitis was noted in 3, pyomyositis in 2 and necrotizing fasciitis in 2. in four patients there was septicemia. infections in 14 patients (66.6 percent) were associated with anaerobic bacteria, which were the exclusive isolates in 6 patients. in seven patients (33.3 percent) isolates were exclusively aerobic bacteria and in ei ... | 1979 | 425502 |
| conditions for effective bacillus calmette-guérin immunotherapy of postsurgical metastases of 13762a rat mammary adenocarcinoma. | we evaluated critical variables in bacillus calmette-guérin (bcg) immunotherapy of residual 13762a rat mammary adenocarcinoma. bcg was given intratumorally on day 7 of tumor growth and followed by primary tumor excisions on day 20. untreated animals died on about day 40 with axillary nodal and pulmonary parenchymal metastases. bcg-treated animals experienced prolonged survival, and some were cured. the highest dose (5.0 x 10(7) colony-forming units) of bcg was more effective than the lowest (0.5 ... | 1979 | 427785 |
| effects of corynebacterium parvum and bcg therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. i. changes in blood counts, serum immunoglobulins and lymphoid cell populations. | the effects of a single immunization of melanoma patients with bcg or c. parvum on the blood counts, serum immunoglobulin levels and lymphoid subpopulations were followed by multiple assays over 28 days. c. parvum produced a decrease in the white cell count, lymphocyte count and lymphoid t and sig+ cell numbers, which recovered within 1 week; bcg did not produce such a marked depression. both agents were associated with increases in t cell numbers and lymphocyte pha blastogenesis after the first ... | 1979 | 428146 |
| fatal infection with pseudomonas aeruginosa in mice treated with cyclophosphamide and propionibacterium acnes. | | 1979 | 428451 |
| laboratory induction and clinical occurrence of combined clindamycin and erythromycin resistance in corynebacterium acnes. | corynebacterium acnes strains cross-resistant to clindamycin and erythromycin were observed following long-term selection or mutagenic treatment in the laboratory. similar strains were found among clinical isolates from patients using clindamycin or erythromycin topically in the treatment of acne vulgaris. clindamycin resistance was never observed in the absence of resistance to macrolides or other lincosaminides. it is suggested that this resistance may result from an alteration of the 50s ribo ... | 1979 | 429800 |
| [participation of methylcobalamin in the methylation of propionibacterium shermanii dna]. | propionibacterium shermanii is characterized by a high content of 5-methylcytosine (5 mc). the level of 5-mc in b12-deficient cells of the culture is twice as low as in the control. the in vitro treatment of dna isolated from the b12-deficient cells with methyl-cobalamin in the presence of the extract of control cells possessing the activity of dna-methylase increases the content of 5-mc to the control level. no additional methylation of dna in vitro takes place in the absence of the methylase s ... | 1979 | 440158 |
| aerobic and anaerobic bacterial flora of the maternal cervix and newborn gastric fluid and conjunctiva: a prospective study. | aerobic and anaerobic cultures were performed on cervical swabs from 35 mothers and their newborn infants' gastric aspirates and conjunctival sacs. four hundred seventy-nine isolates were obtained; 287 were aerobes and 192 were anaerobes. the cervical and gastric cultures overall yielded a similar flora, but this was not always the case when one compared mothers with their own newborn infants. the conjunctival cultures yielded about half of the number of bacteria per specimen that the gastric co ... | 1979 | 440845 |
| [porphyrin production of propionibacterium acnes]. | | 1979 | 442749 |
| lack of effect of immunotherapy with bcg and corynebacterium parvum on hepatic drug hydroxylation in man. | serial serum diphenylhydantoin and urinary 5-(p-hydroxphenyl)-5-phenylhydantoin concentrations were determined in 8 patients with malignant disease and 4 healthy volunteers on 2 separate occasions after an oral dose of diphenylhydantoin (500 mg). no significant difference was observed between metabolism before and 10 days after immunization with bcg or corynebacterium parvum. volunteers without intervening immunization similarly showed no difference. | 1979 | 444399 |
| metabolic changes following the intravenous infusion of corynebacterium parvum in man. | the acute changes in concentrations of key blood metabolites and liver function tests were measured following intravenous infusion of corynebacterium parvum in 9 healthy patients who had recently undergone resection of a colorectal cancer. the following results were obtained: 1) blood glucose, lactate and ketone body concentrations significantly increased over a 5 hour study period; 2) blood alanine fell during the same period; 3) plasma bilirubin, got and urea were significantly elevated 24 hou ... | 1979 | 445333 |
| immunotherapeutic response of concanavalin a-bound l1210 vaccine enhanced by a streptococcal immunopotentiator, ok-432. | immunotherapeutic response to concanavalin a (con a)-bound l1210 murine leukemic vaccine and immunopotentiators was examined in histocompatible animals bearing a small burden l1210 leukemic cells. when combined with con a-bound vaccine, a streptococcal immunopotentiator, ok-432 (nsc b116209), prepared from streptococcus pyogenes, was potent in antitumor therapy and resulted in a number of cured animals. administration of either con-a-bound vaccine or ok-432 alone did not produce any beneficial e ... | 1979 | 445486 |
| chemoimmunotherapy in the management of primary stage iii ovarian cancer: a gynecologic oncology group study. | the effectiveness of chemoimmunotherapy was evaluated in 45 previously untreated stage iii ovarian cancer patients. response rate, progression-free interval, and survival were considerably better than in a similar group of 63 patients treated with a single alkylating agent alone. | 1979 | 445505 |
| effect of 1(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (acnu) on sato lung carcinoma (slc). preliminary result of immunochemotherapy for slc by combination of acnu and propionibacterium acnes. | acnu was highly effective for sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of acnu for slc showed clear dependence upon tumor size. nonspecific activation of host-defence mechanism by propionibacterium acnes contributed to the suppression for the regrowth of solid slc treated by acnu. | 1979 | 450390 |
| positive correlation between the levels of natural killer cells and the in vivo resistance to syngeneic tumor transplants as influenced by various routes of administration of corynebacterium parvum bacteria. | | 1979 | 455483 |
| macrophage activation and increased resistance to infection in immunosuppressed mice treated with corynebacterium parvum vaccine or pyran copolymer. | | 1979 | 458782 |
| quantitative and functional differences induced in bone marrow-derived mononuclear phagocytes by inflammatory stimuli. | | 1979 | 458783 |
| [prospects of short-term sequential immunomodulation with levamisole and corynebacterium parvum in neoplastic pathology in the aged]. | | 1979 | 460632 |
| [postoperative prevention of recurrence with intrapleural corynebacterium parvum in patients with stage i and ii bronchial carcinomas. ludwig lung cancer study i]. | the ludwig lung cancer group was created in 1977. participants are from austria, denmark, germany, norway, sweden, switzerland, and yugoslavia. 400 patients are randomized yearly. the clinical trial i investigating the role of c. parvum intrapleurally as adjuvant therapy in operable non-small cell lung cancer patients has been closed in february 1979 with a total accrual of 475 patients. the average follow-up time for these cases is approximately 8 months. it is early to make any definitive comp ... | 1979 | 462160 |
| effect of corynebacterium parvum in prevention and reversal of atrophy of the liver following portacaval shunt. | since it has been demonstrated that the administration of corynebacterium parvum is associated with increased hepatocyte proliferation in both normal and regenerating livers, it seemed appropriate to determine whether the use of this agent would affect the hepatic atrophy which occurs following end-to-side portacaval shunts. when administered at shunting, liver weight and liver deoxyribonucleic acid failed to decrease to the same extent as that occurring in untreated, shunted rats. an increase i ... | 1979 | 462347 |
| investigations on the bacteriostatic effect of benzoyl peroxide. | | 1979 | 464656 |
| is there postdefecation bacteremia? | an investigation was done to determine the incidence of postdefecation bacteremia. a study of 82 healthy volunteers was done. among 164 predefecation cultures, only one (0.6%) from an anaerobic flask was positive for microorganism, which was identified as staphylococcus epidermidis. in only two of 328 (0.6%) postdefecation cultures did microorganisms grow, which were shown to be propionibacterium acnes. the results of this study suggest that either bacteremia after defecation does not occur or i ... | 1979 | 464809 |
| regression of regionally advanced melanoma after arterial infusion with cis-platinum and actinomycin-d. | | 1979 | 466896 |
| choriogonadotropin-like antigen in an anaerobic bacterium, eubacterium lentum, isolated from a rectal tumor. | using the indirect fluorescein-labeled and indirect peroxidase-antiperoxidase-labeled immunohistochemical techniques, and utilizing both antiserum specific for the beta-subunit of choriogonadotropin and antiserum for the total hormone, we have demonstrated the presence of a choriogonadotropin-like immunoreactive material in a strain of eubacterium lenthum that was originally isolated from a rectal tumor. in contrast, both immunohistochemical reactions were negative when applied to a strain of co ... | 1979 | 468380 |
| the effect of bacterially produced vitamin b12 analogues (cobamides) on the in vitro absorption of cyanocabalamin. | an incubation system containing rat jejunoileum was used to determine whether analogues of cyanocabalamin (cncbl) inhibited the in vitro absorption of cncbl. the naturally occurring analogues "pseudo b12," "factor a," and the nonnaturally occurring analogue desdemethyl b12, were produced by guided biosynthesis with propionibacterium arabinosum. factor b was produced by acid cleavage of cyanocabalamin. inhibition of co57-cnbbl uptake was demonstrated for cold cncbl and for desdemethyl b12, altho ... | 1979 | 474472 |
| [equal sensitivity of normal or tumoral fibroblasts to cytotoxic and cytostatic effects of normal or "corynebacterium parvum" activated peritoneal exudate cells (author's transl)]. | cytotoxic and cytostatic properties of peritoneal exudate cells from balb/c mice either normal or pretreated with corynebacterium parvum normal were studied using as target cells two lines of balb/c fibroblasts one normal (balb) and one transformed by kirsten virus (k.balb).. c. parvum activated cells displayed higher cytotoxic as measured by 51cr or 3h-thymidine release and cytostatic, as measured by 3h-thymidine incorporation, activities against these lines of syngeneic cells. cytotoxic effect ... | 1979 | 475346 |
| an ultrastructural study of peritoneal mononuclear phagocytes from corynebacterium parvum-injected mice. | peritoneal mononuclear phagocytes harvested from mice 24 h after i.p. injection of c. parvum displayed hypertrophy of the golgi and smooth endoplasmic reticulum complex with attendant increase in lysosome production. the ingested bacilli were identified within phagolysosomes, within which large myelin figures accumulated. in addition to heterophagic vacuoles, autophagosomes and lipid droplets were observed. these latter two inclusions may reflect a direct or indirect cytopathic effect of c. parv ... | 1979 | 475974 |
| inhibition of spontaneous akr leukemia by multiple inoculations of corynebacterium parvum. | in previous studies we have shown that akr mice could be protected from spontaneous leukemia by specific immunotherapy in combination with splenectomy. in this experiment we investigated the effects of nonspecific immunotherapy with c. parvum in a similar regimen. it was found that bi-weekly, ip inoculations of 0.7 mg of c. parvum could significantly protect akr mice from spontaneous tumors, and that splenectomy could not modify this effect. thus, the spleen does not appear to play a determinant ... | 1979 | 476565 |
| sensitivity to chemotherapeutic and immunomodulating agents of two mouse lymphomas and of a macrophage tumor. | the effect of treatment with 15 chemotherapeutic and 10 immunomodulating agents on the growth of t-cell lymphoma el-4, macrophage tumor j774, and b-cell lymphoma 70z/2 of the mouse has been studied using the prolongation of median survival time of tumor-bearing hosts as an index of therapeutic effectiveness. the survival time of mice bearing 70z/2 was prolonged more than 100% by single-agent therapy with actinomycin d, cyclophosphamide, 6-mercaptopurine, mitomycin c, and vinblastine; a similar r ... | 1979 | 476634 |
| enhancement of the thermal response of animal tumors by corynebacterium parvum. | the effect of corynecbacterium parvum treatment on the thermal response of animal tumors was studied. tumors were methylcholanthrene-induced (fsa-ii) and spontaneous (fsa-i) fibrosarcomas in c3hf/sed mice. c. parvum was given i.v. and was followed by local hyperthermia at 43.5 degrees 3 days later. cell survival determined by lung colony assays showed that preadministration of c. parvum insignificantly enhanced the thermal response of both tumors. studies of delay of tumor growth for fsa-ii demo ... | 1979 | 476675 |
| [effect of corynebacterium parvum on serum lysozyme (muramidase) levels (author's transl)]. | an i.v. injection of 548 microgram of killed corynebacterium parvum into c57b1 mice leads to significant changes in serum lysozyme (muramidase) levels. after an initial fall at 24 h, the activity of the enzyme increased progressively, reached a peak on the 9th day and returned to control range after the 15th day. | 1979 | 477851 |
| propionibacterium acnes pneumonia in a patient with lymphoma. | a 57 year-old male with lymphocytic lymphoma developed symptoms of cough, fever and progressive dyspnea accompanied by a diffuse lower lung infiltrate. open lung biopsy revealed multiple micro-abscesses surrounding small bronchioles which yielded a pure growth of propionibacterium acnes. | 1979 | 478654 |
| comparison of the in-vitro antitumor activity of peritoneal cells from mice injected with corynebacterium parvum and corynebacterium liquefaciens. | | 1979 | 478988 |
| dual effect of normal and stimulated macrophages and their conditioned media on target cell proliferation. | | 1979 | 480375 |