Publications

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sarcocystis in feces of coyotes from montana: prevalence and experimental transmission to sheep and cattle. 1978104939
transcription and translation in a pleiotropic streptomycin-resistant mutant of escherichia coli.the role of the ribosomal protein s12 (streptomycin protein) in ribosome function and in other metabolic processes in the cell has been investigated. a spontaneous streptomycin-resistant strain of escherichia coli (sm3) carrying a mutation in the rpsl gene is deficient in its ability to induce the synthesis of the enzyme bets-galactosidase. it was demonstrated that the reduced rate of enzyme synthesis results from deficiencies in both the transcription of the lactose operon and translation of th ...1979104958
leukemia in workers exposed to ethylene oxide.ethylene oxide, a gaseous sterilant extensively used within health care facilities, is known to be a mutagen in bacteria and in human lymphocytes. the environmental protection agency as well as the national institue of occupational safety and health have recently stipulated certain conditions for the use of ethylene oxide despite the lack of case reports or epidemiologic studies concerning carcinogenicity. we report three cases of leukemia that occurred between 1972 and 1977 in a relatively smal ...1979105157
[acute enteritis with "new" pathogens. yersinia infections (author's transl)].infections of the intestinal tract with yersinia enterocolitica and yersinia pseudotuberculosis are known the world over. post-infection reactions like arthritis, erythema nodosum, erythema multiforme, scarlatiniform exanthemata and septicemic types deserve particular clinical attention. the clinical importance of enteric yersinioses has been shown in studies with the identification of significant antibody titers against yersinia enterocolitis and yersinia pseudotuberculosis in 6.71 and 4.58% re ...1979105284
[isolation of treponemas from the colon of pigs with clinical dysentery].optimal culture conditions in artificial nutritive media were determined for a defined avirulent strain of treponema hyodysenteriae and for four field strains of treponemas in pigs with clinical dysentery. the treponemas were isolated with the use of milliporous filters with pores of 0.3 micrometer in diameter, which were located on the surface of blood agar. no significant difference in the influence of equine, bovine or sheep blood on the growth of treponemas was determined. the commercial amo ...1979105448
further observations on the initiation of sperm motility. 1978105770
cryopreservation of antibody-coated human erythrocytes. 1978105832
on the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion in the rhesus monkey.ovariectomized rhesus monkeys bearing hypothalamic lesions which had abolished endogenous lhrh production, as evidenced by a profound reduction in gonadotropin secretion, but in which lh and fsh secretion was reestablished by a chronic intermittent iv infusion of synthetic lhrh (1 microgram/min for 6 min every hour) were used to investigate the sites of the negative and positive feedback actions of estradiol in the control of gonadotropin secretion. the administration of estradiol to such animal ...1978105873
[xerophytic microorganisms multiplying under conditions close to martian ones].the xerophytic cultures bacillus megaterium and mycococcus ruber can grow in the imitated martian conditions. therefore, they are resistant to the extreme factors of the environment: the composition of atmosphere, low pressure, the maximum hygroscopicity of a substrate, periodic freezing-thawing.1979106224
mutagenic effect of 7, 12-dimethylbenz[a]anthracene-epidioxide on salmonella typhimurium. 1979106234
a cost-benefit analysis of a mandatory premarital rubella-antibody screening program. 1979106279
[calcium kinetics of myocardium in experimental hypercalcemia and isoproterenol lesions--ultrastructural and roentgen microanalytical findings]. 1978106573
demonstration of the intermediate cells of billingham and medawar in the epidermis of macaca mulatta and rhesus monkey.the digest of the pure epidermis preparation from macaca mulatta demonstrated three types of dendritic cells i.e. (1) dopa-positive melanocytes, (2) dopa-negative langerhans' cells and (3) weakly dopa-positive intermediate cells of billingham and medawar. the last type of cell was found to have characteristics being intermediate between those of the melanocytes and of the langerhans' cell. a similar digest prepared from the epidermis of the rhesus monkey demonstrated isomorphous dendritic cells ...1979106619
the role of catecholamines in clinical medicine.the sympathetic nervous system is of major importance for the regulation of several physiological functions. drugs which inhibit the actions of catecholamines and adrenergic drugs are used in the treatment of many clinical disorders. the potential role of catecholamines in a number of human diseases has, however, until recent years been studied to a limited extent only due to lack of methods for quantitation of sympathetic nervous activity. after the development of enzymatic isotope-derivative a ...1979106629
immunochemical studies on a yersinia enterocolitica o:9 lipopolysaccharide cross-reacting with brucella abortus and vibrio cholerae extracts.the presence of two distinct lipopolysaccharides in yersinia enterocolitica o:9 is described: one isolated from the aqueous phase and one from the phenol phase (westphal system). the sugar moiety of the phenol phase lipopolysaccharide has been identified as being responsible for the serologic cross-reaction of y. enterocolitica o:9, brucella abortus and vibrio cholerae. the phenol phase antigen consists of glucose, galactose, glucosamine, 2-keto-3-deoxyoctonic acid, heptose, lipid a and a protei ...1978106756
trans-stilbene oxide: a new inducer of rat liver microsomal udp-glucuronyltransferase. 1979106858
structural determination of 'cord factor' from a corynebacterium diphtheriae strain by a combination of mass spectral ionization methods: field desorption cesium cationization and electron impact mass spectrometry studies.the composition and structure of a preparation of 'cord factor' (di-beta-hydroxy acyl trehaloses) from corynebacterium diphtheriae have been determined by a combination mass spectral ionization methods. the methods were tested by means of synthetic 6,6'-dicorynomycolate of alpha-d-trehalose prior to their use on natural products. the determination of the molecular weight of the components and the estimation of their relative abundance in the natural mixture were made by field desorption mass spe ...1978106902
inhibition of neisseria gonorrhoeae by normal human saliva.saliva was found to be a powerful and specific inhibitor of neisseria gonorrhoeae. although 28 other species of bacteria were tested, including neisseria meningitidis, neisseria pharyngis var flava, neisseria lactamica, and neisseria catarrhalis, we failed to find any others sensitive to saliva under similar conditions. the physical properties of the inhibitory substance indicated that it might be salivary alpha-amylase. to test this hypothesis alpha-amylase was extracted from saliva and was sho ...1979106919
[evidence of a circadian sequence of photogonadsensitivity in the ferret].using "skeleton" photoperiods with a primary photofraction of 3 hrs. 30 min. and secondary photofraction of 30 min. located at various intervals after the onset of darkness, the occurrence of a photoinducible phase in the androgenic function has been evidenced in the ferret. this photo-inducible phase seems to be located around 12 hrs. after the onset of the primary photofraction, since the ferrets who received the 30 min. photofraction 8 hrs. after the onset of darkness responded with a maximal ...1978106984
penicillin-resistant gonorrhea. 1979106997
liver transplantation. 1979107000
effect of proteases on the structure and activity of rabbit skeletal muscle glycogen synthetase. 1979107043
rapid demineralization in acidic buffers.the demineralization of routine histological specimens in buffers of weakly ionized organic acids, unbuffered formic acid, and edta was investigated. the rate of demineralization was measured by a chemical method and from radiographs. lactate-containing buffers and buffers of formic acid with its potassium salt were more rapid in effect than any other agent. acidic buffers and unbuffered formic acid produced rapid diffuse demineralization with secondary precipitation of calcium salts. preservati ...1979107151
regulation of teichoic acid synthesis during phosphate limitation.bacillus subtilis w-23, when placed in phosphate-free medium, ceases to synthesize teichoic acid and synthesizes teichuronic acid. the enzymatic basis for the cessation of teichoic acid synthesis is the irreversible inhibition of the first membrane-bound enzyme involved in teichoic acid synthesis which catalyzes the reaction undecapenol-p + udp-glcnac leads to undecaprenol-p-p-glcnac + ump.1979107156
acetylated methylmannose polysaccharide of streptomyces griseus. locations of the acetyl groups.the positions of esterification of the 4 to 5 acetyl residues in the acetylated methylmannose-containing polysaccharide from streptomyces griseus have been established by the methyl replacement technique, wherein ester substituents are specifically replaced with methyl ether substituents. the newly incorporated methyl groups were distinguished from 3-o-methyl groups by the use of polysaccharide containing radioactively labeled endogenous methyl groups. the positions of methyl group localization ...1979107171
dietary protein, aryl hydrocarbon hydroxylase and chemical carcinogenesis in rats. 1979107295
effects of dietary composition on somatomedin activity in growing rats. 1979107298
tumor-host responses to various nutritional feeding procedures in rats.parenteral and enteral nutrition are being used as adjuncts to cancer therapy. a liquid diet formulation containing a 27% solution of glucose and 3.9% crystalline amino acids with electrolytes and vitamins was given continuously for a week via parenteral (iv), and via intragastric (ig) routes and also was given ad libitum via the oral or per os (po) route to groups of buffalo rats with and without a morris no. 7777 transplantable hepatoma to find out how these feeding procedures affect tumor-hos ...1979107299
pseudomonas endocarditis. 1979107332
single-antibiotic therapy for streptococcal endocarditis.ninety-nine patients treated with penicillin g potassium, cephalothin sodium, or vancomycin hydrochloride were studied to evaluate single-drug therapy for nonenterococcal streptococcal endocarditis. eighty-six patients survived; of these, 66 received penicillin alone. the maximum serum bactericidal titer obtained at the expected nadir of serum antibiotic concentration was 1:8 or greater in 70 (95%) of the 74 patients studied. no relapse occurred among the 66 patients treated wih penicillin. only ...1979107335
partial purification of heat-labile hemolysin from pseudomonas aeruginosa. 1978107353
heat-labile enterotoxigenic escherichia coli infections in new arrivals at subic naval base, the philippines. 1979107483
[preparation of extracellular ribonuclease from bacillus subtilis].the paper describes a method for isolating alkaline ribonuclease from the culture liquid bacillus subtilis kp 349 which involved: submerged cultivation of the producer on complex and synthetic nutrient media with optimized rnase activity, acid treatment of the total culture liquid, and filtration through perlite. further treatment may include either spray drying of the culture liquid filtrate or its concentration in a vacuum evaporator, dialysis of the concentrate against distilled water, and d ...1978107517
prolongation of islet allograft survival following in vitro culture (24 degrees c) and a single injection of als.isolated rat islets remain morphologically and functionally intact during a 7-day period of in vitro culture at 24 degrees c. in vitro culture of islets at 24 degrees c for 7 days prior to transplantation, in conjunction with a single injection of antiserum to lymphocytes into the diabetic recipient, results in islet allograft survival of 100 days when the islets are transplanted across a major histocompatibility barrier.1979107588
frequency and fate of human renal allografts contaminated prior to transplantation.bacterial cultures were done from donor ureter and/or graft perfusion fluid on 92 of 112 patients who had renal transplantations during 1977. three samples of perfusion fluid and 14 samples of donor ureter contained bacteria. in nine cases there was a gram-positive organism, and in 10 cases a gram-negative rod was (among) the contaminant(s). there was no difference in the rate of graft survival, patient survival, or in the frequency of major postoperative complications between the two groups. on ...1979107605
postnatal development of resistance against infection in an experimental model.the postnatal development of resistance against infection was monitored by the treatment of juvenile mice with a virulent strain of listeria monocytogenes. it could be shown that until day 10 after birth, young mice succumbed to an infection with even minimal doses of bacteria. between day 15 and 30, the resistance against infection gradually increases until the rather constant level of grown-up animals is reached (fig. 1). juvenile mice that survive the primary infection are able to build up a ...1978107682
uv versus chemical polymerization of glycol methacrylate (gma) in enzyme histochemistry.the influence of the mode of polymerization of gma on the enzyme activities of differently fixed rat livers was studied. it was found that with increasing time of uv-polymerization several enzyme activities were inhibited whereas chemical polymerization was comparatively less harmful. the histochemical reactivity of substrates such as glycogen was not impaired by the mode of polymerization, which is in contrast to the increased basophilia of dna and rna after uv-polymerization.1978107707
stability and viability of neisseria gonorrhoeae in various solutions and buffers.the stability and viability of neisseria gonorrhoeae wp (t4) was tested in a variety of buffers and solutions, many of which are commonly used in gonococcal research. each solution was tested at room temperature for its ability to maintain stability and viability of gonococci in concentrated suspensions and to maintain viability of gonococci in dilute suspensions. the 14 buffers and solutions tested could be divided into four groups based upon these criteria. only a few solutions satisfied all t ...1979107855
two functional types of neurons in the superficial layers of monkey superior colliculus. 1978107871
albumin-coated amberlite xad-7 resin for hemoperfusion in acute liver failure. part i: adsorption studies.platelets adhere to most foreign surfaces. as a result, polymers and albumin have been suggested as possible coatings to improve the blood compatibility of such surfaces. amberlite xad-7 has a high affinity for human serum albumin (hsa) and several protein-bound toxic metabolites. in the present study it is shown that hsa can be tightly bound to amberlite xad-7 without the use of chemical coupling agents. optimal binding was achieved at ph 5.0 and the adsorption conforms to langmuir's isotherm. ...1979107929
spinal cord evaluation by cortical evoked responses.in ten monkeys, selective segmental lesions of the dorsal columns at the upper thoracic and middle cervical levels resulted in almost total attenuation of the cortical evoked potential responses to peripheral nerve stimulation. conversely isolated segmental dorsal column preservation showed intact transmission of the evoked responses at rostral spinal cord, nucleus ventralis posterior lateralis, and cortical levels. responses recorded from the intralaminar thalamic nuclei in the region of nucleu ...1979107931
induction of reaginic (ige) gonococcal antibodies in the rat by a common antigen of neisseria gonorrhoeae.an antigen (zab) common to neisseria gonorrhoeae was prepared by stepwise elution of a crude gonococcal antigen (za) from columns of diethylaminoethyl cellulose employing 0.02 m phosphate buffers, ph 7.6, containing increasing concentrations of sodium chloride. rats immunized with zab produced reaginic (ige) antibody which cross-reacted with za prepared from eight gonococcal strains by the passive cutaneous anaphylaxis (pca) test. heating of the sera at 56 degrees c for 4 h destroyed the pca act ...1979108009
[in vitro biosynthesis of beta-lipotropin in brain tissue].we have recently developed methods to identify biosynthetized beta-endorphin and beta-lipotropin (beta-lph) following incubation of rat pars intermedia with radioactive amino acids. we used the same approach for rat brain tissue. in the striatum we found a peptide similar to beta-lph while its identification in hypothalamus was less positive. this is the first demonstration of such biosynthesis and it could well be an important step in determining the biosynthetic patterns of cerebral endorphins ...1979108023
[antiarrhythmic properties of 3-(2-hydroxy-3 isopropylamino-propoxy)-3 phenyl-2 isoindolinone-1, (rs, sr) in the dog].in the dog, 3-(2-hydroxy-3 isopropylamino-proxy)-2-phenyl-1-isoindolinone (rs, sr) possesses an anti-arrhythmic activity similar to that of quinidine but at dose levels 2 to 6 times lower than in the case of the latter compound. furthermore, in contrast to quinidine, at the dose levels where the antiarrhythmic activity is well observed, the compound is devoid of hypotensive activity and of depressive action on cardiac contractility. the first clinical studies of this compound have shown its usef ...1979108025
substrate-labeled fluorescent immunoassay for phenytoin in human serum.a homogeneous substrate-labeled fluorescent immunoassay has been applied to the measurement of phenytoin concentrations in human serum. we coupled a fluorogenic enzyme substrate, galactosyl-umbelliferone, covalently to a derivative of phenytoin. under assay conditions, this drug-substrate conjugate was nonfluorescent but became fluorescent upon hydrolysis catalyzed by bacterial beta-galactosidase. when antibody to phenytoin is bound to the drug-substrate conjugate, it is inactive as an enzyme su ...1979108033
immunoelectrophoretic studies on human small intestinal brush border proteins. a quantitative study of brush border enzymes from single small intestinal biopsies.a method for measuring brush border membrane enzymes from small intestinal biopsies by crossed immunoelectrophoresis is presented. the use of a brush border specific antiserum made isolation of the brush border membrane before analysis unnecessary. this prevented loss of material which, together with inactivation of enzymes, was a limiting factor in previous studies of brush border enzymes from peroral biopsies. in 58 biopsies from patients without gastrointestinal disorders a close correlation ...1979108036
epilepsy, attentiveness and consciousness: recent contributions from behavioral and physiological investigations. a summary and commentary. 1978108075
fascioloides magna: development in selected nonruminant mammalian hosts. 1979108129
inhibition of 7,12-dimethylbenz[alpha]anthracene-induced mammary tumorigenesis in rats by a synthetic protease inhibitor, n,n-dimethylamino-(p-(p'-guanidinobenzoyloxy)) benzilcarbonyloxyglycolate.oral administration of n,n-dimethylamino-(p(p'-guanidinobenzoyloxy))-benzilcarbonyloxy glycolate depressed induction of breast tumors in rats by a single intravenous injection of 7,12-dimethylbenz[alpha]anthracene. the latent period was delayed in the group fed on a diet supplemented with n,n-dimethylamino-(p(p'-guanidinobenzoyloxy))benzilcarbonyloxy glycolate. administration of this compound for 40 days after 7,12-dimethylbenz[alpha]anthracene also significantly reduced the average weight of tu ...1978108169
demonstration of human apolipoprotien a in isolated mucosal cells from small intestine and isolated hepatocytes.isolated mucosal cells from the human jejunum and stomach, cryostat sections from the jejunum, isolated parenchymal liver cells and lymphocytes were investigated for the presence of apolipoprotien a (apoa). antisera against purified human apoa-i and apoa-ii were raised in rabbits and conjugated with fluorescein-isothiocyanate (fitc). mucosal cells from jejunum and stomach were isolated with pronase from tissue obtained from operated patients. apoa-i and apoa-ii could be demonstrated in isolated ...1979108182
a solid-phase radioimmunoassay for bacterial lipopolysaccharide.a radioimmunoassay for e. coli 055:b5 lipopolysaccharide (lps) is described. the lps was derivatised by two new methods and subsequently radiolabeled with 125i to a specific activity of 2-4 mci/mg without apparent loss in its biophysical, immunological or biological activities. using antibody-coated polystyrene tubes, a solid-phase radioimmunoassay was developed with a sensitivity of 10-500 ng/ml of lps.1979108200
macaca assamensis as a new host for experimental plasmodium knowlesi infection. 1978108217
limitations of aeruginocine typing of ps. aeruginosa as an epidemiological marker. 1978108218
age as a modifying factor of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in the lewis rat. 1979108227
pregnant mare serum gonadotropin. purification and physicochemical, biological, and immunological characterization. 1979108273
demonstration and characterization of specific binding sites for factor viii/von willebrand factor on human platelets.the presence of specific factor viii/von willebrand factor (fviii/vwf) binding sites on human platelets has been demonstrated by using 125i-fviii/vwf and washed human platelets. binding is ristocetin-dependent and increases in proportion to the concentration of ristocetin from 0.2 to 1 mg/ml. binding of 125i-fviii/vwf to platelets can be competitively inhibited by unlabeled human or bovine fviii/vwf, but not by human thrombin, fibrinogen, alpha 2-macroglobulin, equine collagen, or a lectin of ri ...1979108291
changes in the activity of lactose synthetase in the goat udder during pregnancy.the lactose synthetase activity of homogenates and particulate fractions prepared from the udders of goats killed at various stages of pregnancy were determined. both components of the enzyme, galactosyltransferase and alpha-lactalbumin, became detectable about half way through the gestation period, at the time when rapid proliferation of mammary epithelial tissue commences. throughout the second half of pregnancy the udder possessed a high level of lactose synthetase activity though the lactose ...1979108321
aging in the rhesus monkey: effects on visual discrimination learning and reversal learning.the behavior of aged rhesus monkeys (18 years and older) was compared to that of young monkeys (3 to 6 years old) to evaluate their relative abilities to learn a series of visual discrimination and discrimination reversal problems. using a subject-paced, automated experimental procedure designed to optimize stimulus control and facilitate execution of choice responses, no consistent age-related differences were observed in the ability to learn new color and pattern discrimination problems of var ...1979108323
growth and food intake of prematurely weaned rats: effect of cortisone and thyroxine injection during the suckling period. 1979108369
effect of n-trifluoroacetyl derivatives of amino acids and amino acid analogs on microbial antitumor screen.eighteen trifluoroacetyl derivatives of amino acids and of amino acid analogs were prepared and tested for growth-inhibitory activity using a lactobacillus casei system as a prescreen for antitumor activity. of the compounds tested, the trifluoroacetyl derivatives of o-, m-, and p-fluorophenylalanine and of beta-3-thienylalanine showed modest activity; trifluoroacetyl derivatives of phenylalanine and of beta-2-thienylalanine showed marginal activity. the activity exhibited by the active trifluor ...1979108385
comparison of ketmine with the combination of ketamine and xylazine for effective anesthesia in the rhesus monkey (macaca mulatta).the addition of xylazine to ketamine hydrochloride was found to enhance analgesia, anesthesia, and muscle relaxation in rhesus monkeys. at 0.10 ml/kg body weight, this combination provided adequate anesthesia for such procedures as cisternal puncture, lumbar spinal puncture, insertion of urinary catheters, finger amputations, and tattooing. the combination of ketamine and xylazine did depress the heart rate, respiration rate, and body temperature more than the administration of ketamine alone. t ...1978108468
neurofibrillary pathology: current status and research perspectives.the neurofibrils seen in the light microscope are shown, by electron microscopy, to be heterogeneous structures, formed of neurotubules and neurofilaments. a variety of pathological conditions (especially, presenile and senile dementia (are characterized by the presence of neurofibrillary tangles, formed either of paired helical filaments or of single filaments. the morphology, distribution and biochemistry of these various fibrillary structures is reviewed. particular attention is devoted to th ...1979108483
[anti-neisseria meningitidis antibodies, groups a and c, in individuals from urban and rural regions of argentina]. 1978108502
immobilization of pyridoxal 5'-phosphate and pyridoxal 5'-phosphate-dependent enzymes on sepharose. 1979108513
isolation of an influenza virus subtype hav4navl from a budgerigar. 1979108521
aflatrem, the tremorgenic mycotoxin from aspergillus flavus. 1979108599
aphasia: the sole manifestation of focal status epilepticus.aphasia was the sole manifestation of focal status epilepticus in a man with an old left frontal contusion. the diagnosis was made by electroencephalogram (eeg), and the attack was terminated by anticonvulsant medication.1979108612
response of periapical pathosis to endodontic treatment in monkeys.response of induced periapical lesions in monkeys to a conventional endodontic technique was investigated at varying periods ranging from 15 to 365 days after treatment. the findings indicate that response to treatment is influenced by the extent of the root canal filling, the time lapse between treatment and death, and the presence or absence of bacteria in the apical portion of the canal.1979108648
[new species of microsporidians (microsporidia, nosematidae) from horsefly larvae in the ukraine].a new species of microsporidians, stempellia lairdi sp. n., was found in larvae of tabanus autumnalis l. from ukraine. it affects the muscular tissue and haemolymph of horse fly larvae. spores of the species are oval, egg-shaped, 1.8--7.6 x 1.2--3.8 mu in size. the species is pathogenic and causes the mortality of infected larvae.1979108652
[effect of microsporidiosis on the fertility of aedes caspius caspius (culicidae) mosquitoes].effect of microsporidiosis on the fecundity of hosts a. c. caspius was studied. the calculation of eggs in hatches has shown that females developing from infected eggs lay 2--3 times lesser eggs than non-infected ones. besides, the number of females laying eggs decreases considerably. despite the females of mosquitoes suck blood before each egglaying the disease, which proceeds at their larval stage, affects greatly their fecundity. additional feeding of females cannot compensate completely the ...1979108654
[on the antimicrobial activity of propolis and propolis constituents (author's transl)].after a survey of the literature on the antimicrobial activity of the bee product propolis, the authors discuss their own findings as compared to the chemotherapeutical agents streptomycin, oxytetracycline, chloramphenicol, nystatin, griseofulvin and sulphamerazine. according to the results obtained by testing 25 isolated constituents on bacillus subtilis, staphylococcus aureus, candida albicans and trichophyton mentagrophytes, the antimicrobial properties of this mixture of natural substances a ...1979108687
mechanisms of control of the reproductive function by olfactory stimuli in female mammals. 1979108689
the effects of alcohol on agonistic behavior in the telomian dog.the study analyzed the effects of alcohol on agonistic behavior in three independent social systems, each compromised of two male and one female telomian dog. three dose levels were used: 0, 0.8, and 1.6 g/kg body weight of absolute alcohol diluted to 20%. observations were made when none, one (top, middle or low ranking), or all dogs in a system received a given treatment. at the 0.8 g/kg level, low ranking dogs showed an increased frequency of attacks and bone possession time, while top and mi ...1979108707
sex differences following pharmacological manipulation of the cholinergic system by dfp and pilocarpine. 1979108719
dietary modification of amphetamine stereotyped behaviour: the action of tryptophan, methionine, and lysine.rats fed diets high in tryptophan, methionine, and tryptophan plus methionine or lysine were subsequently injected with 10 mg/kg d-amphetamine. the amount of amphetamine-induced stereotyped behaviour observed varied as a function of the dietary addition, with methionine showing the greatest difference to controls, and lysine the least. whole brain catecholamine levels and 5-hydroxytryptamine levels also showed amino acid-specific changes.1979108724
enhanced 5-hydroxytryptamine-mediated behavioural responses in rats following repeated electroconvulsive shock: relevance to the mechanism of the antidepressive effect of electroconvulsive therapy.treatment of rats with one electroconvulsive shock (ecs) per day for 10 days enhanced the hyperactivity syndrome produced by administration of tranylcypromine (10 mg kg-1) and l-tryptophan (50 mg kg-1) given 24 h after the final shock. similar enhancement was seen whether the shock was alternating sinusoidal or direct current (fractionated), whether it was given through unilaterally or bilaterally placed electrodes and whether or not a neuromuscular blocking agent (fazadinium) was used. five sho ...1979108733
comparison of the discriminative stimulus properties of nefopam and morphine.separate groups of rats were trained to discriminate nefopam or morphine from saline in a two-lever operant task. nefopam produced saline-appropriate responding in morphine-trained rats. the highest dose of morphine tested in nefopam-trained rats produced responding appropriate for neither training treatment. this intermediate morphine responding was antagonized by a naloxone treatment that had no effect on the nefopam discrimination. these results suggest that the stimulus properties of nefopam ...1979108741
"routine."--a practice to be abjured. 1979110537
lethal effect of protamine and histone on competent bacillus subtilis cells. inhibition of genetic transformation by protamine in sublethal concentration.under experimental conditions of genetic transformation, protamine and total histone were bactericidal for bacillus subtilis cells. the abilities to cause lethality were very similar for both, either protamine or histone, with no antagonistic effects amongst these natural polycations. with both basic proteins acting simultaneously the enhancement was higher than a summation of the separate lethal effects. sublethal concentration of protamine added at the beginning of transformation time, produce ...1979111002
hallucinogen-induced rotational behavior in rats. 1979111284
evaluation of high-protein supplements in children with protein energy malnutrition.the present study was designed to test the comparative efficacy of cow's milk, a protein, vitamin and mineral mixture (pvm) and soybean textured vegetable protein (somos) as supplements to maize meal porridge in the dietary treatment of children with protein energy malnutrition (pem). each diet was designed to provide approximately 480 kj/kg with 2 protein/kg from the test protein, and 1,8 g protein/kg from maize. response to treatment was measured by loss of oedema, subsequent weight gain, rate ...1979111358
cerebellar cortical atrophy in an adult japanese macaque. 1979111404
lethal effects of 32p decay on transfecting activity of bacillus subtilis phage phi e dna. 1979111411
a radial immunodiffusion method for the measurement of rat fibrinogen and fibrin degradation products.the present report describes a technique for the production of monospecific rabbit antiserum to rat fibrinogen and its use in a quantitative radial immunodiffusion assay for measurement of rat fibrinogen and fibrin degradation products. it is a suitable technique for measurement of these parameters in small samples which can be repeatedly obtained from animals the size of rats.1979111420
observations on l-forms of yersinia enterocolitica. 1979112256
pharmacokinetics in the interpretation of chronic toxicity tests: the last-in, first-out phenomenon. 1979112717
isolation of yersinia enterocolitica serotype 0: 3 from captive monkeys and domestic pigs in zaire. 1978112929
morphology and morphogenesis of a new paramyxovirus (pmv 107).the morphology of the virions and nucleocapsids of paramyxovirus 107 (pvm 107) and the replication of the virus were investigated by electron microscopy. the virions and nucleocapsids exhibited the same structural properties as other paramyxoviruses. nuclecapsids were found in the nucleus and cytoplasm of infected bovine embryonic lung (bel) cell cultures. a similar situation has been described for the morbilliviruses measles, sspe, distemper and rinderpest. alignment of nucleocapsids beneath th ...1979113501
sensitization of myelinated nociceptive afferents that innervate monkey hand. 1979115969
sugar hydrolases and their arrangement on the rat intestinal microvillus membrane.the arrangement of the sugar hydrolases, sucrase-isomaltase, maltase, and lactase on the microvillus membrane of rat intestine was investigated by immunological technique. the enzymes were purified essentially free of each other to near homogeneity and antisera of high specificity were obtained against each. microvillus membranes were prepared routinely in high purity from rat intestine and contained an average 61% protein, 20% lipid, and 19% carbohydrate, with the sugar hydrolases comprising an ...1979116006
[lipoamino acids in the composition of actinomycete polar lipids].the capacity for substitution of phospholipids, in particular phosphatidyl ethanolamine, by a phosphorus-lacking lipoamino acid was studied in different groups of actinomycetes. in the conditions of phosphorus deficiency, most cultures were found to be capable of synthesizing a phosphorus-lacking nitrogen-containing lipoamino acid. its characteristics (rf) in tlc are similar to those of ornithinolipid. this fact confirms, for the first time and for different groups of actinomycetes, the hypothes ...1979116114
folacin deficiency and requirement in the squirrel monkey (saimiri sciuresus).acute folacin deficiency was studied in eight young squirrel monkeys (saimiri sciureus). half of the animals were fed a semipurified deficient diet (no added folic acid) and half were fed a control diet (0.84 mg of added folic acid per kilogram of dry diet). monkeys fed the deficient diet lost weight and suffered from diarrhea and dehydration leading to the death of one of the animals after 6 weeks. folacin deficiency also was studied in six older animals fed diets containing varying levels of a ...1979116540
evaluation of the moving intermediate zone concept for determing susceptibility of pseudomonads to gentamicin by the standardized disk agar-diffusion test.the usefulness of the moving intermediate zone concept for improving the performance of the standardized disk agar-diffusion test in measuring susceptibility of the fluorescent group of pseudomonads to gentamicin was studied. for this purpose, a 3-mm moving intermediate zone lying --3 mm and --6 mm below that measured for the quality control microorganism pseudomonas aeruginosa, atcc 27853, and a wider moving intermediate zone lying --2 mm and --7 mm below that for the quality control microorgan ...1979116543
complement in tears from normal humans.tears from ten normal persons were used in hemolytic assays to test for activity of total hemolytic complement (tested in all ten subjects), activities of each of the nine complement components (tested in two subjects), and activity of the alternate pathway (tested in two subjects). a modified radial-immunodiffusion method was used to confirm the presence of c3 and c4 complement proteins in the tear samples from all ten subjects. factor b protein was detected in tears from two of four normal sub ...1979116549
spontaneous zinc deficiency in marmosets, saguinus mystax.moustached marmosets, saguinus mystax, developed alopecia, skin lesions and general debilitation approximately 6 months after being brought into our laboratory. these lesions resembled the signs of zinc deficiency in pigs, rats and squirrel monkeys. the marmosets were fed a commercial monkey diet containing 150 parts per million zinc and about 100 g of apples and oranges per week. the addition of 40 parts per million zinc to the drinking water brought about improvement in hair coat and skin cond ...1979117220
effect of dyes on the quantitative recovery of yersinia enterocolitica.a total of 69 dyes were incorporated separately at different concentrations into an agar medium for evaluation of their effects on the quantitative recovery of five serotypes of yersinia enterocolitica. one strain of pseudomonas aeruginosa and one strain of bacillus cereus were included for comparative purposes. certain dyes were evaluated further for their selective properties with five additional serotypes of y. enterocolitica, three strains of p. aeruginosa, and two of engerobacter spp. metan ...1979117750
in vitro response to rosette inhibition factor (rif) and rosette restoring factor (rrf) of human lymphocyte after fractionation on a discontinuous density albumin gradient.in vitro studies on peripheral blood lymphocytes from tuberculous patients and healthy subjects are reported. factors isolated from human serum used in the experiments included the rosette inhibition factor (rif) from serum of tuberculous patients and the rosette restoring factor (rrf) from serum of healthy subjects. lymphocytes were fractionated on a discontinuous bsa gradient. lymphocytes from healthy subjects, sensitive to rif, as well as lymphocytes from tuberculous patients, sensitive to rr ...1979117785
[modelling modification of chemical mutagenesis in human cells. iii. linear index of protection as the standardized criterion of modification].the effect of substances with radioprotective activity, apaetp 2,3 (aminopropylaminoethylthiophosphoric acid 2,3), apaetp 3,3 and cystaphos, on chromosome aberrations, induced by thiotepa in the culture of human lymphocytes was investigated. it is shown that the obtained curves "concentration -- effect" for thiotepa can be described by equations rho = 1 -- e-(kc + alpha)2 and x = e -(kc + alpha)2 --1 for aberrant cells and for chromosome breaks in the presence of the investigated substances. on ...1979118079
contribution to the definition and the taxonomy of yersinia enterocolitica.the phenotypic study of 6,000 strains of y. enterocolitica and y. enterocolitica-like organisms by the biochemical reaction of the identification of enterobacteriaceae on one hand and of 100 strains representing different chemiotypes by an auxanogram technique shows a large homogeneity of these strains which are apparated from the other yersinia within enterobacteriaceae. six chemiotypes are described. the strains fermenting thamnose, similar to chemiotype i, can be subdivided in two groups acco ...1979119609
numerical classification of yersinia enterocolitica and relationship between its subdivision and pathogenicity.a total of 102 strains of yersinia enterocolitica were studied on their morphology, physiology and biochemistry at 25 degrees c. all data coded in binary notation and similarities between each pair of strains by simple matching coefficient were calculated using subsequent computation. four clusters were distinguished within the 102 strains at a similarity level of 90--93%. although some discrepancies were recognized on reactions of indole, xylose, esculin and salicin, it was evident that 3 of th ...1979119610
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