| atypical presentation of legionella pneumonia among patients with underlying cancer: a fifteen-year review. | immunocompromised patients, especially those receiving treatment with corticosteroids and cytotoxic chemotherapy are at increased risk for developing legionella pneumonia. | 2015 | 26496794 |
| atypical presentation of legionella pneumonia among patients with underlying cancer: a fifteen-year review. | immunocompromised patients, especially those receiving treatment with corticosteroids and cytotoxic chemotherapy are at increased risk for developing legionella pneumonia. | 2015 | 26496794 |
| prevalence and molecular characteristics of waterborne pathogen legionella in industrial cooling tower environments. | cooling towers are a source of legionnaires' disease. it is important from a public health perspective to survey industrial cooling towers for the presence of legionella. prospective surveillance of the extent of legionella pollution was conducted at factories in shijiazhuang, china between march 2011 and september 2012. overall, 35.7% of 255 industrial cooling tower water samples showed legionella-positive, and their concentrations ranged from 100 colony-forming units (cfu)/liter to 88,000 cfu/ ... | 2015 | 26473896 |
| legionella micdadei: a forgotten etiology of growing cavitary nodules: a case report and literature review. | background. legionella micdadei is a gram negative bacterium that can stain weakly acid fast. it was first described in 1979 after immunosuppressed patients developed pneumonia at a pittsburgh va, initially given the name pittsburgh pneumonia agent. it is the second most common legionella species causing infection after pneumophila, and typically infects immunocompromised hosts. it is not easy to be cultured which makes diagnosing difficult. case presentation. a 31-year-old female with ulcerativ ... | 2015 | 26451267 |
| utility of pcr, culture, and antigen detection methods for diagnosis of legionellosis. | the goal of this retrospective study was to evaluate the performance of different diagnostic tests for legionnaires' disease in a clinical setting where legionella pneumophila pcr had been introduced. electronic medical records at the cleveland clinic were searched for legionella urinary antigen (uag), culture, and pcr tests ordered from march 2010 through december 2013. for cases where two or more test methods were performed and at least one was positive, the medical record was reviewed for rel ... | 2015 | 26292304 |
| rash, disseminated intravascular coagulation and legionella: episode 10 and a rewind into the past. | legionella pneumophila is the most common cause of legionellosis and is one of the organisms causing atypical pneumonia. we report the presentation of disseminated intravascular coagulation (dic) and skin rash in a single case of severe legionella pneumonia. the unique clinical presentation of a diffuse rash diagnosed as purpura fulminans and the unpredictable variations encountered during the diagnostic work-up of the case make this write-up crucial. this article synthesizes all reported cases ... | 2015 | 26236615 |
| microbiological and clinical studies of legionellosis in 33 patients with cancer. | legionella, a large group of environmental gram-negative bacteria, represents an occasional cause of pneumonia. we analyzed the microbiological and clinical features of 33 consecutive cases of legionella infections that occurred at the university of texas md anderson cancer center, houston, tx, from 2002 to 2014. the legionella strains were isolated from bronchoscopy specimens (32 strains) and a blood culture (1 strain) and were identified by sequencing analysis of the full-length 16s rrna gene. ... | 2015 | 25926494 |
| mistaken identity: legionella micdadei appearing as acid-fast bacilli on lung biopsy of a hematopoietic stem cell transplant patient. | legionella micdadei is a potential cause of invasive lung infections in immunocompromised hosts. on biopsy specimens, it can appear as an acid-fast bacillus (afb) and can be mistaken for a member of genus mycobacterium. as legionella requires selective media to grow in culture, and the commonly used, commercially available urine antigen test for legionella only detects legionella pneumophila serogroup-1, but not l. micdadei, it is important to consider this organism in the differential diagnosis ... | 2015 | 25573597 |
| active and adaptive legionella crispr-cas reveals a recurrent challenge to the pathogen. | clustered regularly interspaced short palindromic repeats with crispr-associated gene (crispr-cas) systems are widely recognized as critical genome defense systems that protect microbes from external threats such as bacteriophage infection. several isolates of the intracellular pathogen legionella pneumophila possess multiple crispr-cas systems (type i-c, type i-f and type ii-b), yet the targets of these systems remain unknown. with the recent observation that at least one of these systems (ii-b ... | 2016 | 26936325 |
| determination of viable legionellae in engineered water systems: do we find what we are looking for? | in developed countries, legionellae are one of the most important water-based bacterial pathogens caused by management failure of engineered water systems. for routine surveillance of legionellae in engineered water systems and outbreak investigations, cultivation-based standard techniques are currently applied. however, in many cases culture-negative results are obtained despite the presence of viable legionellae, and clinical cases of legionellosis cannot be traced back to their respective con ... | 2016 | 26928563 |
| legionella cardiaca sp. nov., isolated from a case of native valve endocarditis in a human heart. | a gram-negative, rod-shaped bacterium, designated h63(t), was isolated from aortic valve tissue of a patient with native valve endocarditis. 16s rrna gene sequencing revealed that h63(t) belongs to the genus legionella, with its closest neighbours being the type strains of legionella brunensis (98.8% similarity), l. londiniensis (97.0%), l. jordanis (96.8%), l. erythra (96.2%), l. dresdenensis (96.0%) and l. rubrilucens, l. feeleii, l. pneumophila and l. birminghamensis (95.7%). dna-dna hybridiz ... | 2012 | 22286905 |
| multiplex real-time pcr assay for detection and differentiation of bordetella pertussis and bordetella parapertussis. | rapid diagnosis of pertussis is important for the timely isolation of the infection source and early prevention measures among the contact persons, especially among non-vaccinated infants for whom pertussis is life-threatening. | 2014 | 25870746 |
| 60 years of progress--cdc and infectious diseases. | | 2006 | 16845775 |
| round pneumonia in an elderly woman. | we describe a case of pneumococcal round pneumonia in an elderly smoker and it demonstrates the role of inflammatory biomarkers and follow-up imaging in ruling out more ominous diagnoses. | 2013 | 25356230 |
| round pneumonia in an elderly woman. | we describe a case of pneumococcal round pneumonia in an elderly smoker and it demonstrates the role of inflammatory biomarkers and follow-up imaging in ruling out more ominous diagnoses. | 2013 | 25356230 |
| high seroprevalence of mycoplasma pneumoniae igm in acute q fever by enzyme-linked immunosorbent assay (elisa). | q fever is serologically cross-reactive with other intracellular microorganisms. however, studies of the serological status of mycoplasma pneumoniae and chlamydophila pneumoniae during q fever are rare. we conducted a retrospective serological study of m. pneumoniae and c. pneumoniae by enzyme-linked immunosorbent assay (elisa), a method widely used in clinical practice, in 102 cases of acute q fever, 39 cases of scrub typhus, and 14 cases of murine typhus. the seropositive (57.8%, 7.7%, and 0%, ... | 2013 | 24147043 |
| legionella micdadei brain abscess. | we describe an immunocompromised patient who developed a large frontal brain abscess caused by legionella micdadei. this is, to our knowledge, a rare case of culture-proven legionella central nervous system infection. | 2013 | 23224082 |
| pulmonary infection by rhodococcus equi presenting with positive ziehl-neelsen stain in a patient with human immunodeficiency virus: a case report. | patients with human immunodeficiency virus carry a significant risk of contracting opportunistic infections. the worldwide increased incidence of tuberculosis has instituted pulmonary tuberculosis as an important diagnostic consideration in patients with human immunodeficiency virus presenting with lower respiratory tract infection. a positive result on the readily-available ziehl-neelsen stain usually leads to the initiation of antituberculous treatment, since tuberculosis may exert a rapid and ... | 2014 | 25495684 |
| 14(th) annual southern hospital medicine conference abstracts. | | 2014 | 24688348 |
| γδ t cells and their potential for immunotherapy. | vγ9vδ2 (also termed vγ2vδ2) t cells, a major human peripheral blood γδ t cell subset, recognize microbial (e)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a tcr-dependent manner. the recognition does not require specific accessory cells, antigen uptake, antigen processing, or mhc class i, class ii, or class ib expression. this subset of t cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and bro ... | 2014 | 24520210 |
| nontuberculous mycobacterial ocular infections: a systematic review of the literature. | nontuberculous or atypical mycobacterial ocular infections have been increasing in prevalence over the past few decades. they are known to cause periocular, adnexal, ocular surface and intraocular infections and are often recalcitrant to medical therapy. these infections can potentially cause detrimental outcomes, in part due to a delay in diagnosis. we review 174 case reports and series on nontuberculous mycobacterial (ntm) ocular infections and discuss etiology, microbiology, risk factors, dia ... | 2015 | 26106601 |
| brain abscess following rituximab infusion in a patient with pemphigus vulgaris. | immunocompromised patients are at increased risk for developing meningitis or, rarely, brain abscess with opportunistic organisms like listeria monocytogenes. | 2015 | 25659437 |
| a nonhuman primate scrub typhus model: protective immune responses induced by pkarp47 dna vaccination in cynomolgus macaques. | we developed an intradermal (id) challenge cynomolgus macaque (macaca fascicularis) model of scrub typhus, the leading cause of treatable undifferentiated febrile illness in tropical asia, caused by the obligate intracellular bacterium, orientia tsutsugamushi. a well-characterized animal model is required for the development of clinically relevant diagnostic assays and evaluation of therapeutic agents and candidate vaccines. we investigated scrub typhus disease pathophysiology and evaluated two ... | 2015 | 25601925 |
| role of brevundimonas vesicularis in supporting the growth of legionella in nutrient-poor environments. | in 1986, we encountered the first case of legionella micdadei pneumonia in japan. in the follow-up study to determine the infection route of l. micdadei, we isolated brevundimonas vesicularis from the shower hose of the patient�s home. this motivated us to explore the symbiosis between b. vesicularis and legionella in this study. b. vesicularis type strain, b. vesicularis kobe strain, legionella pneumophila serogroup 1 type strain, and l. micdadei kobe strain were used. b. vesicularis was inocul ... | 2014 | 24531169 |
| simultaneous detection of legionella species and l. anisa, l. bozemanii, l. longbeachae and l. micdadei using conserved primers and multiple probes in a multiplex real-time pcr assay. | legionnaires' disease is a severe respiratory disease that is estimated to cause between 8,000 and 18,000 hospitalizations each year, though the exact burden is unknown due to under-utilization of diagnostic testing. although legionella pneumophila is the most common species detected in clinical cases (80-90%), other species have also been reported to cause disease. however, little is known about legionnaires' disease caused by these non-pneumophila species. we designed a multiplex real-time pcr ... | 2016 | 27107536 |
| the legionella pneumophila incomplete phosphotransferase system (pts) is required for optimal intracellular growth and maximal expression of pmra regulated effectors. | the nitrogen phosphotransferase system (pts(ntr)) is a regulatory cascade present in many bacteria, where it controls different functions. this system is usually composed of three basic components: ei(ntr), npr and eiia(ntr) (encoded by the ptsp, ptso and ptsn genes, respectively). in legionella pneumophila, as well as in many other legionella species, the eiia(ntr) component is missing. however, we found that deletion mutations in both ptsp and ptso are partially attenuated for intracellular gr ... | 2017 | 28373357 |
| orange sputum in a kidney transplant patient with legionella micdadei pneumonia. | | 2017 | 27133899 |