| [differential affinity of pathogenic species of microorganisms for a set of lectins detectable by the sandwich method using fluorescein isothiocyanate (fitc)]. | the qualitative differences in the affinity of concanavalin a (con a), wheat-germ agglutinin (wga) and phaseolus vulgaris lectin to the surface of 10 microbial strains inducing various diseases in humans and agricultural animals have been demonstrated by means of the indirect immunofluorescence tests. enterobacteria, coxiella burnetii and bacillus anthracis have been found to possess pronounced affinity to con a and wga, while rickettsia prowazekii, francisella tularensis and brucella abortus, a ... | 1985 | 3920844 |
| the diagnostic utility of the febrile agglutinin tests. | the purpose of our study was to analyze the use of febrile agglutinin (fa) serologic tests in the diagnosis of salmonella (typhi and paratyphi), rickettsia, brucella, and francisella infections. data were collected in a retrospective chart study of 202 titer requests covering a 42-month period at our teaching hospital. we found that no diagnoses were made by utilizing complete six-antigen fa panels. three cases of infection were diagnosed serologically, all three with more discriminately selecte ... | 1985 | 3927019 |
| agglutination and elisa methods in the diagnosis of tularemia in different clinical forms and severities of the disease. | | 1986 | 3941279 |
| [development of an immunoenzyme method for detecting francisella tularensis]. | the conditions permitting the determination of f. tularesis cells by means of the enzyme immunoassay (eia) in 3-5 hours have been established. ways for enhancing the reliability of results obtained in the assay of the least possible amount of the test material have been proposed. the sensitivity and specificity of the rapid eia technique permitting the determination of f. tularensis cells at a concentration of 20 000 cells/ml in the presence of other bacterial cells in 100-fold excess have been ... | 1986 | 3962541 |
| tularemia and rhabdomyolysis. | rhabdomyolysis as a complication of tularemia occurred in four patients in tennessee over a four-year period. all patients were severely ill and had renal failure. tularemia was not suspected initially in any of these patients. one patient died of complications of rhabdomyolysis. at autopsy, multiple abscesses were present within skeletal muscle, suggesting that rhabdomyolysis resulted from direct muscle involvement with francisella tularensis. tularemia should be considered in the differential ... | 1985 | 3965776 |
| response of tularemic meningitis to antimicrobial therapy. | a 60-year-old man had pyogenic meningitis due to francisella tularensis acquired by tick bite. his disease initially improved but later relapsed after a standard course of streptomycin. complete resolution resulted from prolonged combined therapy with streptomycin and tetracycline. successful treatment of acute tularemic meningitis has not previously been reported. our experience suggests that therapy should include agents that reliably penetrate the csf, that is, tetracycline or chloramphenicol ... | 1985 | 3975716 |
| [effect of immunization with tularemia vaccine on 3,4-benz[a]pyrene-induced blastomogenesis and mutagenesis in rats]. | the living tularemia vaccine is studied for its effect on rat tumours and chromosome aberrations in bone marrow cells during 3,4-benz(a)pyrene injection (bp). it is established that a single epicutaneous vaccination of rats decreases the incidence of bp-induced tumours, prolongs the latent period and reduces the mean weight of tumours as well as lowers the number of myelocaryocytes with chromosome aberrations when bp is administered 15 days after immunization. 125 days after a single subcutaneou ... | 1985 | 3979338 |
| [preliminary study of tularemia in humans and the tick (dermacenter marginatus) populations in ta-cheng district of the xinjiang uygur autonomous region]. | | 1985 | 3995569 |
| determination of monounsaturated double-bond position and geometry in the cellular fatty acids of the pathogenic bacterium francisella tularensis. | the nonhydroxy fatty acid composition of francisella tularensis is reported in detail. the double-bond configuration of the monounsaturated acids has been determined by capillary gas chromatography-mass spectrometry of the derivatized fatty acids. the monounsaturated fatty acids detected, in decreasing order of abundance, were 24:1 omega 15c, 18:1 omega 9c, 22:1 omega 13c, 20:1 omega 11c, 16:1 omega 7c, 26:1 omega 17c, and 14:1 omega 7c. the fatty acid profile found in f. tularensis, in particul ... | 1985 | 3998104 |
| oculoglandular syndrome caused by francisella tularensis. | oculoglandular syndrome developed in a 9-year-old boy with a recent history of tick bites and minor eye trauma. francisella tularensis was isolated on chemically supplemented chocolate agar from a swab of a conjunctival ulcer and an aspirate of a preauricular lymph node, confirming the diagnosis of tularemia. in addition, a rise in agglutination titer to the pathogen was detected in paired sera. the differential diagnosis of oculoglandular syndrome is discussed, with emphasis on the clinical cha ... | 1985 | 4017402 |
| [experimental multifactorial study of the effect of doxycycline and glucosaminylmuramyl dipeptide on the primary immunologic response to antigens of a tularemia vaccine strain]. | the effect of the combined use of doxycycline and glucosaminylmuramyl dipeptide (gmdp) on the primary immune response to antigens of tularemia vaccine was studied on cba male mice with the use of the multifactorial design of experiment. antibodies to the blood serum of the immunized animals were determined by the passive hemagglutination test with the use of the tularemia antigen diagnosticum. the delayed type hypersensitivity was estimated by changes in the weight of the extremities of the expe ... | 1985 | 4026257 |
| antimicrobial susceptibility testing of francisella tularensis with a modified mueller-hinton broth. | a modified mueller-hinton broth was developed to perform antimicrobial susceptibility tests on francisella tularensis. adequate growth of the organism was obtained within 24 h of inoculation, and mics could be read at that time. we tested 15 selected strains of f. tularensis and five reference quality control strains in this medium with 36 antimicrobial agents. the mics of the aminoglycosides and tetracycline increased 1 to 3 dilutions in this medium compared with those in the usual medium, but ... | 1985 | 4031036 |
| tick-borne tularemia. an outbreak of lymphadenopathy in children. | between june 1 and july 15, 1984, twenty persons with glandular tularemia were identified on the lower brule and crow creek indian reservations in south dakota. the median age of the patients was 6 years (range, 2 to 20 years). the clinical illness was mild, consisting of fever, headache, and lymphadenopathy. all lymphadenopathy was in the head and neck area. dermacentor variabilis ticks were identified as the vector. although the mild clinical illness suggested francisella tularensis, type b, w ... | 1985 | 4057512 |
| humoral immunity against francisella tularensis after natural infection. | forty-two subjects with acute tularemia were studied for the occurrence of c-reactive protein (crp), and 73 subjects with acute tularemia or experience of the disease within the last 11 years were studied for immunoglobulin m (igm), iga, and igg class-specific antibodies, agglutinating antibodies, and complement-fixing antibodies to francisella tularensis by using an enzyme-linked immunosorbent assay (elisa), the tube agglutination test, and a complement-fixing elisa. the incubation time between ... | 1985 | 4066925 |
| [effect of immunization with live tularemia vaccine on the growth of various tumor strains in rats]. | the paper deals with a study of the effect of a single challenge with living tularemia vaccine on the growth of such transplantable tumors as zajdela's hepatoma, pliss' lymphosarcoma, walker's carcinosarcoma, schwetz' erythromyelosis and sarcoma 45 in wistar rats. immunization was followed by a significant (37.2-86%) inhibition of the rate of growth of the said tumors. ascites was detected in half the vaccinated animals of zajdela's hepatoma series, this being matched by 100% in controls. | 1985 | 4072086 |
| humoral immunity induced by a live francisella tularensis vaccine. complement fixing antibodies determined by an enzyme-linked immunosorbent assay (cf-elisa). | a complement-fixing enzyme-linked immunosorbent assay (cf-elisa) with bacterial sonicate as the antigen, human ab serum as the source of complement and alkaline-phosphatase-labelled anti-(human c3c) as the conjugate was developed for detecting antibodies to francisella tularensis. humoral responses after inoculation with a live attenuated tularemia vaccine were studied in 13 subjects by this method. twelve responded with cf antibodies, which in most cases appeared 4 weeks after vaccination, the ... | 1985 | 4082752 |
| airborne transmission of tularemia in farmers. | in a tularemia epidemic during 1982 in northern finland, 53 patients showed no peripheral portal of entry for infection or associated lymphadenopathy. respiratory symptoms were observed in 72% of the patients. 26/38 cases had abnormal chest films. hilar adenopathy was the most common finding (36%). four patients did not receive antibiotics; 43 received tetracyclines, 5 streptomycin and 1 cefuroxime and amoxycillin. all patients recovered. 50 patients acquired the infection during common farming ... | 1985 | 4089543 |
| [effect of the combined use of rifampicin and a low-molecular immunomodulator of natural origin on the primary immune response to the antigens of a tularemia vaccinal strain]. | the effect of rifampicin combination with a natural low molecular immunomodulator on the primary immune response to the antigens of tularemia vaccine was studied with the methods of multifactor designing of the experiment. the dependence of the delayed hypersensitivity and antibody titer on doses of the antibiotic and immunomodulator and the time of the immunomodulator administration was manifested by the second order equation. nomographs for precise quantitative estimation of the doses and regi ... | 1985 | 4091512 |
| electron-microscopic study of localization of antigens in francisella tularensis by means of ferritin-labelled antibodies. | | 1970 | 4099755 |
| microagglutination test for detecting and measuring serum agglutinins of francisella tularensis. | a microagglutination method utilizing stained antigen for detecting and measuring serum agglutinins against francisella tularensis is described. the microagglutination and standard tube agglutination techniques were demonstrated to be comparable in sensitivity and specificity. advantages of the micro method are rapidity and ease of performance, economy of reagents and, in particular, ease of interpreting specific reactivity. | 1974 | 4129476 |
| [ornithonyssus bacoti mites as pest on a farm]. | | 1973 | 4133599 |
| [detection of dissociation of tularemia microbe cultures by the method of staining of colonies]. | | 1974 | 4139347 |
| characterization of human serum and nasal hemagglutinating antibody to francisella tularensis. | | 1967 | 4163639 |
| fluorescein-labeled beta-glucosidase as a bacterial stain. | fluorescein isothiocyanate-labeled beta-glucosidase was used as a simple staining reagent with selected gram-positive and gram-negative organisms. staining in situ appeared to be dependent on the presence of accessible glycosidic-type linkages in the bacterial cell wall. extensive wall damage or lysis did not occur when stained cells were suspended in washing and mounting solutions. the apparent specificity of labeled enzyme for wall substance was tested by blocking reactions, staining of isolat ... | 1967 | 4169543 |
| [on the method of determination of initial stages of glycerin metabolism in geographic varieties of the causative agent of tularemia]. | | 1968 | 4185826 |
| [differentiation of geographic races of francisella tularensis on the basis of citrulline ureidase activity]. | | 1970 | 4192178 |
| tularaemic pneumonia: pathogenesis of the aerosol-induced disease in monkeys. | | 1973 | 4200656 |
| zoonotic potential (rocky mountain spotted fever aed tularemia) in the tennessee valley region. ii. prevalence of rickettsia rickettsi and francisella tularensis in mammals and ticks from land between the lakes. | | 1974 | 4204021 |
| zoonotic potential (rocky mountain spotted fever and tularemia) in the tennessee valley region. i. ecologic studies of ticks infesting mammals in land between the lakes. | | 1974 | 4204030 |
| [isolation of the a-antigen of the tularemia microbe]. | | 1973 | 4205255 |
| [the physico-chemical properties and allergenic activity of peptides of various species of bacteria]. | | 1973 | 4205258 |
| [submicroscopic structure of the bacterial cell wall (review of the literature)]. | | 1973 | 4206610 |
| the mediator of cellular immunity. vii. localization of sensitized lymphocytes in inflammatory exudates. | peritoneal exudates induced in rats infected with listeria monocytogenes contain sensitized lymphocytes which can protect normal recipients against a listeria challenge. the protective cells arise in lymphoid tissue remote from the peritoneal cavity. those formed in the caudal lymph nodes of subcutaneously infected rats are delivered to the thoracic duct and hence to the blood from where they are drawn into exudates. immunoblasts are the most immature members of this protective cell population a ... | 1974 | 4208417 |
| [rapid processing of material for the antibody neutralization test in case of detection of antigen of tularemia and f-1 plague]. | | 1974 | 4214964 |
| vaccine potencies of the live vaccine strain of francisella tularensis and isolated bacterial components. | | 1974 | 4215444 |
| [p-antigen of the causative agent of tularemia]. | | 1974 | 4218034 |
| [plague, tularemia and anthrax immunization with associated di- and trivaccines using a jet injector. i]. | | 1974 | 4218042 |
| [studies on the sensitivity of francisella tularensis to antibiotics in vitro]. | | 1967 | 4229465 |
| [on the factors of the stable maintenance of natural microfoci of tularemia in the steppe zone of the stavropol area]. | | 1969 | 4239987 |
| [tularemia in the orenburg region. ii]. | | 1969 | 4239988 |
| [on the mechanism of persistence of the plague microbe on the plains of azerbaijan]. | | 1969 | 4240558 |
| tularemia in a pet squirrel monkey (saimiri sciureus). | | 1970 | 4249657 |
| production of interferon-like inhibitor in chickens after secondary induction by bacteria and virus. | | 1968 | 4385157 |
| characterization of the endogenous mediator(s) of serum zinc and iron depression during infection and other stresses. | | 1971 | 4399096 |
| the definition and application of evaluation techniques as a guide for the improvement of fluorescent antibody reagents. | | 1971 | 4400555 |
| further studies on tularemia in alaska: human tularemia. | | 1974 | 4434260 |
| further studies on tularemia in alaska: virulence and biochemical characteristics of indigenous strains. | | 1974 | 4434261 |
| [tularemia laboratory infection]. | | 1974 | 4445529 |
| [evaluation of tularemia vaccine strains in experiments on rabbits]. | | 1974 | 4454858 |
| [attempts at growing francisella tularensis in cell cultures in vitro]. | | 1974 | 4471744 |
| human infections with francisella tularensis in norway. development of a serological screening test. | | 1972 | 4503972 |
| first detection of tularaemia in domestic and wild mammals in iran. | during a study on the ecology of small-mammal-borne infections in iran, over 4 600 wild mammals were collected at 47 localities. attempts were made to isolate francisella tularensis from the spleens of 3 548 of these animals. all were found to be negative. in addition, sera from 200 sheep and cattle and from 39 wild mammals were tested: 8 sheep, 3 oxen, and 1 hedgehog showed evidence of recent infection. this is the first report of tularaemia in iran. the relationship of these findings to the po ... | 1973 | 4548386 |
| aerosol survival of pasteurella tularensis and the influence of relative humidity. | the aerosol survival in air was determined for pasteurella tularensis live vaccine strain (lvs) as a function of relative humidity (rh). three different preparations of bacteria were used: (i) liquid suspension of p. tularensis lvs in spent culture medium; (ii) powders of p. tularensis lvs freeze-dried in spent culture fluid; (iii) p. tularensis lvs freeze-dried in spent culture fluid and then reconstituted with distilled water and disseminated as a liquid suspension. preparation (i) gave greate ... | 1972 | 4551041 |
| infection-immunity in tularemia: specificity of cellular immunity. | the relationship between hypersensitivity and cellular resistance to infection with facultative intracellular parasites was studied in mice by using infection-immunity in tularemia as a model system. delayed hypersensitivity to antigenic fractions of francisella tularensis was first detected 6 to 7 days after immunization with viable f. tularensis vaccine, at which time immunity against challenge infection developed. both immunity and delayed-type sensitivity reached maximal levels by 9 to 10 da ... | 1972 | 4564560 |
| tularemia: dr. edward francis and his first 23 isolates of francisella tularensis. | | 1972 | 4570449 |
| [history of the study of the causative agent of tularemia]. | | 1973 | 4585673 |
| oysters: retention and excretion of three types of human waterborne disease bacteria. | | 1974 | 4586734 |
| [use of the fluorescent antibody technic for detection of the agent of tularemia in the organs of experimentally infected animals]. | | 1973 | 4595602 |
| [experimental mixed infection in muskrats (omsk hemorrhagic fever and tularemia)]. | | 1974 | 4613000 |
| [experimental production of specific fluorescent tularemia serum using a non-virulent strain]. | | 1974 | 4614554 |
| the antigenic structure of francisella tularensis. i. isolation of the ether antigen and its fractionation. | | 1972 | 4624012 |
| function of the alveolar macrophage in immunity. | | 1972 | 4624744 |
| the antigenic structure of francisella tularensis. ii. fractionation of the ether antigen on cellulose carriers and by gel filtration. | | 1972 | 4627016 |
| methods for the assessment of microbial populations recovered from enclosed aerosols. | | 1972 | 4627206 |
| rapid assays for the detection and determination of sparse populations of bacteria and bacteriophage t7 with radioactively labelled homologous antibodies. | | 1972 | 4627207 |
| pathogenesis of tularemia in monkeys aerogenically exposed to francisella tularensis 425. | the pathogenesis of tularemia was studied in groups of rhesus monkeys (macaca mulatta) that inhaled graded 10-fold doses ranging from 10 through 10(6) organisms of francisella tularensis 425, a strain highly virulent for the white mouse but of reduced virulence for the domestic rabbit. mean incubation periods ranged from 3 to 6 days followed by acute illness lasting 5 to 11 days with subsequent recovery of most animals. the higher inhaled doses resulted in shorter incubation periods, longer and ... | 1972 | 4629251 |
| susceptibility of tularemia bacilli to the antagonistic action of cocci. | | 1972 | 4632426 |
| experimental tularemia in macaca mulatta: relationship of aerosol particle size to the infectivity of airborne pasteurella tularensis. | ninety-six macaca mulatta were exposed to aerosol particles containing pasteurella tularensis. four different aerosols were employed that contained particle size distributions with median diameters of 2.1, 7.5, 12.5, or 24.0 mum. size distributions were calculated only for those particles observed by phase microscope to contain organisms. animals exposed to particles whose median diameters were either 2.1 or 7.5 mum were all infected and showed extensive infection of the lower respiratory tract, ... | 1972 | 4632469 |
| survival of airborne pasteurella tularensis at different atmospheric temperatures. | the aerosol survival, recovery, and death rate of pasteurella tularensis schu s5 disseminated in particle sizes of 1 to 5 mum were significantly affected by air temperature. the highest aerosol recovery of viable p. tularensis was observed within -7 and 3 c; the recovery decreased significantly below and above this temperature range. the death rate of airborne p. tularensis was not significantly influenced by an increase in temperature from -40 to 24 c. however, a progressive increase in atmosph ... | 1973 | 4633423 |
| [experience of a 25-year study of the stability of properties of tularemia vaccine strains]. | | 1972 | 4643653 |
| bacteriological study of a natural focus of tularemia in the lake reserve of srebrna, the silistra region, bulgaria. | | 1972 | 4673074 |
| [study of the toxicity of f. tularensis following the action of ionizing irradiation]. | | 1973 | 4711422 |
| tularemia epidemic associated with the deerfly. | | 1973 | 4740907 |
| tularemia. | | 1973 | 4740911 |
| effects of hypobaric hyperoxia on the development and activity of immune spleen cells. | | 1973 | 4744245 |
| [determination of fibrinolytic activity of the causative agent of tularemia]. | | 1973 | 4785009 |
| [change in the properties of the causative agent of tularemia due to erythromycin]. | | 1973 | 4785841 |
| afghan hedgehog, a new reservoir of tularemia. | | 1973 | 4801900 |
| nonspecific staining: its control in immunofluorescence examination of soil. | gelatin preparations were used to treat soil slides prior to addition of fluorescent antibody. nonspecific staining was avoided, with no detectable interference to specific staining. gelatin-rhodamine conjugates served to counterstain as well as to prevent nonspecific staining. | 1968 | 4880718 |
| influence of bacterial infection on serum enzymes of white rats. | infection of white rats with francisella tularensis (pasteurella tularensis) and salmonella typhimurium and exposure to the endotoxin of s. typhimurium stimulated significant increases in various serum enzymes including aldolase, lactate dehydrogenase, phosphohexose isomerase, isocitrate dehydrogenase, and glutamate-oxalacetate transaminase. the rates of changes in enzymatic activity after infection were directly related to the size of infecting dose and to the type of infective agent employed. ... | 1969 | 4886856 |
| tularemia epidemia: vermont, 1968. forty-seven cases linked to contact with muskrats. | | 1969 | 4891088 |
| the effects of francisella tularensis infection on iron metabolism in man. | | 1969 | 4894492 |
| cellular response of mice to infection with pasteurella tularensis (live vaccine strain) following continuous exposure to low dose gamma radiation. | | 1969 | 4898414 |
| preparation of agglutinating antisera and fluorescent-antibody conjugates against pasteurella tularensis in equines. | the serological response in burros and horses to the viable lvs strain of pasteurella tularensis was studied. high-titered agglutinating antisera and fluorescent-antibody conjugates were obtained in both groups of animals. maximum titers were obtained in horses 14 to 21 days after the start of vaccination and in burros 21 to 28 days after the start of vaccination. the use of woodhour's adjuvants or booster inoculations did not result in increased titers. | 1970 | 4917187 |
| demonstration of francisella tularensis (syn. pasteurella tularensis) in sylvan animals with the aid of fluorescent antibodies. | | 1970 | 4922256 |
| antitissue versus antimicrobial cellular immunity: a perspective. | | 1971 | 4941265 |
| effect of infection and endotoxicosis on plasma lactate dehydrogenase isozymes in white rats. | vertical slab electrophoresis in polyacrylamide gels was used to monitor changes in lactate dehydrogenase (ldh) isozymes in plasma of white rats during bacterial infection and endotoxin poisoning. peritoneal infection with francisella tularensis and salmonella typhimurium and administration of s. typhimurium endotoxin stimulated significant increases in plasma ldh-5. rates of change in enzyme activity after infection were directly related to size of infecting dose and type of agent employed. inf ... | 1971 | 4949502 |
| effect of aerosol age on the infectivity of airborne pasteurella tularensis for macaca mulatta and man. | sawyer, william d. (u.s. army medical unit, fort detrick, frederick, md.), joseph v. jemski, arthur l. hogge, jr., henry t. eigelsbach, elwood k. wolfe, harry g. dangerfield, william s. gochenour, jr., and dan crozier. effect of aerosol age on the infectivity of airborne pasteurella tularensis for macaca mulatta and man. j. bacteriol. 91:2180-2184. 1966.-in aging aerosols of pasteurella tularensis schu-s4, the respiratory infectivity for man and macaca mulatta decreased more rapidly than the via ... | 1966 | 4957611 |
| [a study of the antigenic composition of some strains of p. tularensis. i]. | | 1965 | 4960676 |
| a virus inhibitor circulating in the blood of chickens, induced by francisella tularensis and listeria monocytogenes. | | 1967 | 4961829 |
| polynucleotide homologies of brucella deoxyribonucleic acids. | deoxyribonucleic acids (dna's) extracted from organisms presently placed in the genus brucella (b. abortus, b. melitensis, b. neotomae, and b. suis) possessed very similar polynucleotide sequences. unlabeled, single-stranded dna fragments from b. abortus, b. melitensis, b. neotomae, and b. suis were equally effective in competing with the interaction of corresponding radiolabeled, single-stranded dna fragments with their homologous dna-agars. unlabeled fragments of b. ovis, however, did not comp ... | 1968 | 4966546 |
| [karyometric study of the reaction of cells in monolayer tissue culture of human embryo to infection with virulent bacterial strains]. | | 1966 | 4968845 |
| [immunochemical characteristics of 2 geographic strains of tularemia microbes]. | | 1967 | 4969633 |
| toxicity of open air to a variety of microorganisms. | | 1969 | 4975276 |
| effect of vaccine, route, and schedule on antibody response of rabbits to pasteurella tularensis. | the response of the rabbit to viable or killed whole-cell pasteurella tularensis vaccines was studied. the most practical preparation for the production of anti-p. tularensis antibodies was viable organisms of the live vaccine strain (lvs). the intravenous route of administration proved superior to either the subcutaneous or intradermal routes, and incorporation of lvs into freund's adjuvants did not result in increased levels of antibody. short-term hyperimmunization, three injections at weekly ... | 1969 | 4976322 |
| [on a method of setting up the indirect hemagglutination test with antibody-sensitized erythrocytes]. | | 1966 | 4978070 |
| [a study of the antigenic composition of various strains of the tularemia microbe. ii. comparative antigenic composition of a virulent and avirulent microbe]. | | 1966 | 4978575 |
| [antigenic and immunologic interrelationships between brucellae and the agents of tularemia]. | | 1967 | 4979510 |
| antibodies in nonhuman primate to selected bacterial antigens. | | 1969 | 4981658 |
| oral vaccination against tularemia in the monkeys. | | 1969 | 4982863 |