| erosive prepyloric changes in dyspeptics and non-dyspeptics in a defined population. the sørreisa gastrointestinal disorder study. | in this population-based endoscopic survey we found erosive prepyloric changes (epc) in 38.5% of dyspeptics and 35.1% of non-dyspeptics. epc were observed more frequently in men than in women in both groups. occurrence of helicobacter pylori was not associated with epc. no common gastrointestinal symptoms were found to be associated with epc. endoscopic duodenitis of the duodenal bulb was found more frequently in subjects with epc of the two highest grades than in subjects without epc. only the ... | 1992 | 1502487 |
| double-blind randomized trial of bismuth subsalicylate and clindamycin for treatment of helicobacter pylori infection. | we evaluated clindamycin and bismuth subsalicylate (pepto-bismol) for treatment of helicobacter pylori infection. patients with culture or histology positive for h. pylori were randomized to receive two tablets of bismuth subsalicylate four times daily for 4 weeks or bismuth combined with 2 weeks of 300 mg clindamycin four times daily. clinical symptoms were recorded before and after treatment by means of visual analog scales. patients in both treatment arms showed improvement in clinical scores ... | 1992 | 1502490 |
| helicobacter pylori infection--a common worldwide environmental risk factor for gastric cancer? | | 1992 | 1505491 |
| recurrent abdominal pain of gastro-intestinal origin. | a consecutive series of 71 children (mean age 8.6 years) with recurrent abdominal pain underwent endoscopic oesophageal, gastric and duodenal biopsy in order to determine whether the pain was of gastro-intestinal origin. of these 71 children, 27 (38%) showed oesophagitis, 14 (20%) cardiac gastritis, 29 (41%) body gastritis, 38 (54%) antral gastritis, and 29 (41%) duodenitis. thus, 66 of the 71 children studied had an inflammatory lesion explaining their complaints. one of the patients had a gast ... | 1992 | 1505571 |
| helicobacter pylori in north indian subjects. | | 1992 | 1506055 |
| proposed mechanism for metronidazole resistance in helicobacter pylori. | metronidazole mic values were determined for ten isolates of helicobacter pylori. under microaerobic conditions four were inhibited by less than 0.25 mg/l, two strains required 2.0 mg/l and four strains had mic greater than 32 mg/l. the strains were tested for their susceptibility to metronidazole after varying lengths of anaerobic exposure prior to or during microaerobic incubation. the susceptibility was determined by e-test and traditional agar dilution technique. the level of susceptibility ... | 1992 | 1506325 |
| [differential diagnosis of peptic ulcer]. | although new pathogenetic findings of peptic ulcers have been detected, there still remain some open questions. accurate anamnestic evaluation will find out risk factors as cigarette-smoking, stress and therapy with nonsteroidal antiinflammatory drugs (nsaids), and will be helpful in differential diagnosis. endoscopy is the diagnostic means of choice, and enables to easy helicobacter pylori detection. since some gastric ulcers are actually carcinomas, it is absolutely necessary to obtain multipl ... | 1992 | 1509765 |
| [helicobacter pylori. new apsects in the pathogenesis of peptic ulcer disease]. | antral gastritis and peptic ulcer disease are closely related to gastric helicobacter pylori (hp) infection. hp possesses several pathogenic features which point to a causal role of hp in the development of gastroduodenal lesions. it is now generally accepted that hp causes type b gastritis, while its role in the pathogenesis of peptic ulcers is still unsolved. according to the classical ulcer concept, peptic ulceration is the result of an imbalance between protective mucosal mechanisms and aggr ... | 1992 | 1509766 |
| helicobacter pylori infection in a pediatric population: in vitro susceptibilities to omeprazole and eight antimicrobial agents. | the in vitro activities of omeprazole and eight antimicrobial agents against 18 clinical strains of helicobacter pylori isolated from a pediatric population were determined by an agar dilution method. ampicillin and erythromycin were the most active agents in vitro. all strains were susceptible to azithromycin, ciprofloxacin, doxycycline, metronidazole, and tinidazole. one isolate demonstrated resistance to cefixime (mic, greater than or equal to 4 micrograms/ml). h. pylori was inhibited by the ... | 1992 | 1510406 |
| the genetics, epidemiology, and early detection of gastrointestinal cancers. | current recommendations for screening large populations for colorectal neoplasia have been promulgated by a number of researchers and authorities who generally agree that ongoing screening is justifiable in high-risk groups but not yet in average-risk groups. nonetheless, it is thought to be justifiable to provide screening for average-risk individuals upon request. choice of tools for screening remains under discussion. colonoscopy is generally agreed to be justifiable in those patients with th ... | 1992 | 1511028 |
| [detection of campylobacter species by using polymerase chain reaction and nonradioactive labeled dna probe]. | we have detected campylobacter species which are now recognized as major pathogens of acute diarrheal disease in humans using polymerase chain reaction (pcr) and a nonradioactive labeled dna probe. diagnosis of campylobacter enteritis without doing culture from stool samples is of great benefit in the laboratory. two oligonucleotide primers (20 mer) complementary to a unique sequence of the dna encoding ribosomal rna (rrna) of campylobacter jejuni for pcr were synthesized by solid-phase phosphoa ... | 1992 | 1513035 |
| fluoride as a possible aetiological factor in non-ulcer dyspepsia. | a prospective case controlled study was conducted to evaluate the role of fluoride as a possible aetiological factor for non-ulcer dyspepsia (nud). twenty patients with nud and 10 age and sex matched healthy controls were subjected to clinical evaluation, upper gastrointestinal endoscopy and biopsies from the gastric antrum and duodenum. the antral and duodenal mucosa was subjected to a rapid urease test for helicobacter pylori and histological and electron microscopic examinations. fluoride lev ... | 1992 | 1515558 |
| helicobacter pylori serology in patients with coeliac disease and dermatitis herpetiformis. | to investigate whether helicobacter pylori infection or autoimmune gastritis is responsible for the reported increase in gastric pathology and abnormalities of gastric function in patients with coeliac disease and dermatitis herpetiformis (dh). | 1992 | 1517459 |
| helicobacter pylori infection in children: clinical, endoscopic, and histologic correlations. | we have assessed 270 consecutive patients (age range 0.8-20 years) referred for endoscopic study because of abdominal pain during 32 months. helicobacter pylori (hp) was detected by culture in 91 cases (33.7%). hp colonization increased significantly with age (p less than 0.01). nine patients less than 5 years of age were colonized by hp. a previous history of peptic ulcer disease in first-degree relatives was significantly more frequent in the hp-positive group (p less than 0.001). the frequenc ... | 1992 | 1517945 |
| ammonia: a possible promotor in helicobacter pylori-related gastric carcinogenesis. | helicobacter pylori (hp) has been shown to possibly be a pathogen of gastric carcinoma. hp has urease activity and produces ammonia in the stomach. in this study, the role of ammonia on gastric carcinogenesis induced by n-methyl-n'-nitro-n-nitrosoguanidine (mnng) were investigated in rats. after 24 weeks pretreatment with mnng (83 mg/l), 0.01% ammonia or tap water as a drinking water was administered for 24 weeks. the ammonia-treated rats showed a significantly higher incidence of gastric cancer ... | 1992 | 1511405 |
| helicobacter pylori. its role in the pathogenesis of peptic ulcer disease in a new animal model. | the association and causative role of helicobacter pylori infection of the stomach with gastric ulcer, duodenal ulcer, non-ulcer dyspepsia, and gastritis has remained controversial. the authors studied the effects of daily intragastric administration of h. pylori suspension in saline (10(8) cfu/ml) and bacteria-free filtrates of saline h. pylori suspensions in 85 sprague-dawley rats (weight, 150 to 200 g) with normal mucosa and with surgically produced experimental gastric ulcers. group i rats ( ... | 1992 | 1519673 |
| igg subclass antibodies against helicobacter pylori heat-stable antigens in normal persons and in dyspeptic patients. | measurement of serum igg antibodies against helicobacter pylori seems to be useful in the diagnosis of h. pylori infections. igg subclass antibodies against h. pylori have, however, not been investigated thoroughly. in this study igg1, igg2, igg3 and igg4 antibody levels against h. pylori were measured using an elisa technique in 187 normal adult persons and in 174 patients with dyspeptic symptoms, of whom 99 patients were h. pylori positive. none of the igg subclass antibody levels were better ... | 1992 | 1520486 |
| helicobacter pylori: its role in disease. | | 1992 | 1520782 |
| prediction of helicobacter pylori in gastric specimens by inflammatory and morphological histological evaluation. | statistical correlations and predictive values were calculated for 330 gastrointestinal biopsies and tissues, of which 248 were from the stomach from 115 patients in this retrospective study, which graded 10 inflammatory and 14 morphological mucosal and submucosal abnormalities and compared them with the presence of helicobacter pylori. analysis revealed that 78 (31.5%) of the 248 stomach biopsies and tissues showed h. pylori, and 21 (8.5%) had non-helicobacter-like bacteria, such as rods and co ... | 1992 | 1519569 |
| [the role of the polyclinic in raising the efficacy of rehabilitation with peptic ulcer patients]. | the authors provide the results of the treatment and prophylaxis of peptic ulcer (pu) patients followed up by the polyclinic for 14 years. on a large factual material they estimate the efficacy of pu patients treatment with the use of drugs belonging to different groups, including drugs that exert antisecretory, cytoprotective and antibacterial effects. during the follow-up period, the number of patients with medium-grave and grave pu decreased whereas that of patients with mild disease and no r ... | 1992 | 1523569 |
| helicobacter pylori and atrophic gastritis. | sixty-four consecutive patients which on upper gastrointestinal endoscopy had endoscopic signs of atrophic body gastritis were investigated with standard histology examinations of gastric biopsies, serology and/or culture for helicobacter pylori and with standard blood chemistry profile. a histologic diagnosis of atrophy could be made in only 27 of the 64 patients (42%). of these 27 patients, 5 had the pernicious anaemia (pa) type (19%), 22 had not (81%). past and/or present h. pylori infection ... | 1992 | 1523687 |
| helicobacter pylori. new diagnostic tools. clinical and experimental studies on local and systemic immune response. minireview based on a doctoral thesis. | | 1992 | 1523731 |
| identification of erythrocyte-binding antigens in helicobacter pylori. | the surface antigens of helicobacter pylori conferring erythrocyte-binding activity were obtained by adsorption onto formaldehyde-treated dog and goat erythrocytes from supernatant fractions of sonicated bacteria and elution using a high concentration of nacl. the desorbed material was analysed by sds-page and immunoblotting with anti-whole-cell serum to agar-grown bacteria which had been absorbed with broth-grown, non-haemagglutinating cells (haemagglutination-associated antiserum). two polypep ... | 1992 | 1512579 |
| management and response to treatment of helicobacter pylori gastritis. | gastritis associated with helicobacter pylori was present in gastric biopsies from 24/95 (25%) children and adolescents undergoing endoscopy for recurrent abdominal pain and upper gastrointestinal symptoms. h pylori associated gastritis occurred mainly in older children (8-16 years) and was significantly associated with low socioeconomic class and a family history of peptic ulcer disease. antral nodularity was a common endoscopic finding in h pylori positive children. eighteen children, all over ... | 1992 | 1519961 |
| serum neutralizing antibody response to the vacuolating cytotoxin of helicobacter pylori. | approximately 50% of helicobacter pylori isolates produce a cytotoxin in vitro that induces vacuolation of eukaryotic cells. to determine the in vivo relevance of this phenomenon, we sought to detect cytotoxin-neutralizing antibodies in sera from h. pylori-infected persons. as a group, sera from 29 h. pylori-infected patients neutralized the activity of the purified cytotoxin to a significantly greater extent than sera from 24 uninfected persons (p = 0.007). the cytotoxin neutralizing activity i ... | 1992 | 1522241 |
| catalase negative mutants of helicobacter pylori. | nine strains of helicobacter pylori have been isolated exhibiting spontaneous mutations with a loss of catalase activity. growth characteristics in vitro were unaffected by the mutation showing that catalase is not essential for growth of helicobacter pylori. parent strains and mutants could not be distinguished morphologically from each other when compared by electron microscopy. restriction endonuclease digestion with hindiii, separated in an 0.7% agarose gel in tbe buffer, showed each pair to ... | 1992 | 1526235 |
| frequency of helicobacter pylori and gastritis in healthy subjects without gastrointestinal symptoms. | to investigate the frequency of helicobacter pylori and gastritis in asymptomatic adults, 30 healthy volunteers underwent upper endoscopy. biopsy specimens were obtained from the corporeal and antral mucosa of the stomach. the specimens were examined by light microscopy for gastritis and the occurrence of h. pylori. in 12 subjects signs of gastritis were noted at endoscopy, but only in 7 of them was this diagnosis confirmed histologically. no other abnormalities were observed by the endoscopist. ... | 1992 | 1529273 |
| longitudinal study of influence of helicobacter pylori on current risk of duodenal ulcer relapse. the hvidovre ulcer project group. | seventy-four patients with duodenal ulcer were followed up longitudinally for 2 years after initial ulcer healing. endoscopy including biopsy of the antral mucosa was performed every 3rd month and whenever clinical symptoms of relapse occurred. the presence of helicobacter pylori in the biopsy specimens was scored as 0 (none), 1 (sporadic occurrence), 2 (clusters), and 3 (numerous bacteria found diffusely in the mucus layer). the incidence rates of ulcer relapse per patient-month, grouped in acc ... | 1992 | 1529279 |
| immunocytochemical identification of rochalimaea henselae in bacillary (epithelioid) angiomatosis, parenchymal bacillary peliosis, and persistent fever with bacteremia. | we report the immunocytochemical identification of rochalimaea henselae, a newly recognized fastidious, gram-negative, warthin-starry-positive organism, as the common pathogen in bacillary angiomatosis (ba), bacillary peliosis (bp) of the liver and spleen, and persistent fever with bacteremia in immunocompromised patients. immunogenic proteins of the r. henselae strain isolated from the blood of a febrile immunocompromised patient with bp of the liver were used to produce primary immune serum in ... | 1992 | 1530106 |
| helicobacter pylori and hypergastrinaemia during proton pump inhibitor therapy. | the rise in serum gastrin and pepsinogen i after 5 days' treatment with the proton pump inhibitor pantoprazole (40 mg/day) was examined in eight duodenal ulcer patients with helicobacter pylori infection and compared with eight in whom it had been eradicated. before treatment, the post-prandial serum gastrin concentrations were higher in the h. pylori-positive than -eradicated patients (p less than 0.05). the median rise in pre-prandial serum gastrin concentrations on treatment was similar in th ... | 1992 | 1532864 |
| gastric emptying, esophageal 24-hour ph and gastric potential difference measurements in non-ulcer dyspepsia. | pathological gastroesophageal reflux, prolonged gastric emptying and abnormal gastric potential difference have been claimed to be functional disorders often detectable in non-ulcer dyspspsia (nud). the role of helicobacter pylori in nud is still unclear. the aim of the present study was to evaluate the prevalence of these factors in 47 patients with nud. according to demeester's criteria, 60 percent of nud patients had abnormal gastroesophageal reflux, while 38 percent had prolonged gastric emp ... | 1992 | 1526393 |
| duodenal ulcer and eradication of helicobacter pylori in a developing country. an 18-month follow-up study. | forty-eight patients with endoscopically proven duodenal ulcer (du) and helicobacter pylori infection detected by 14c-urea breath test (bt) were assigned to 5 days of treatment with furazolidone, metronidazole, and amoxicillin in addition to eventual classical anti-ulcer agents if necessary. clinical evaluation and bt were repeated at 2, 6, and 18 months after therapy to determine h. pylori eradication or reinfection. endoscopy was also repeated at 6 and 18 months after treatment to detect du re ... | 1992 | 1529269 |
| the role of helicobacter pylori in recurrent, functional abdominal pain in children. | recurrent abdominal pain in children usually is considered to be functional in nature. we hypothesized that helicobacter pylori infection might be the etiology of abdominal pain symptoms in some children with presumed functional abdominal pain. therefore, we studied 20 children with a previous diagnosis of functional abdominal pain, using a 13c-urea breath test and an enzyme-linked immunosorbent assay for antibody to the h. pylori high molecular weight, cell-associated antigens. two children had ... | 1992 | 1539570 |
| acute helicobacter pylori infection in an infant, associated with gastric ulceration and serological evidence of intra-familial transmission. | reports of the clinical picture and laboratory findings associated with naturally acquired acute h. pylori infection are rare and, although family studies have suggested person-to-person transmission, there have been no accounts of serologically proven intra-familial spread. this report describes the clinical and histological features associated with acute h. pylori infection in an infant and includes serological evidence for the possible transmission of this organism within his direct family. t ... | 1992 | 1539579 |
| chemical gastritis and helicobacter pylori related gastritis in patients receiving non-steroidal anti-inflammatory drugs: comparison and correlation with peptic ulceration. | to evaluate the prevalence and significance of chemical gastritis, in comparison with gastritis related to helicobacter pylori in patients receiving non-steroidal anti inflammatory drugs (nsaids). | 1992 | 1541693 |
| short report: short-term triple therapy for h. pylori-associated duodenal ulcer disease. | thirty consecutive patients with endoscopically proven duodenal ulceration who had helicobacter pylori infection on culture and histology, were treated with tripotassium dicitrato bismuthate (1 tablet q.d.s., 400 mg metronidazole t.d.s. and 500 mg tetracycline t.d.s. for one week, followed by the bismuth salt for a further 3 weeks. all patients were endoscoped at entry and 4 weeks after cessation of treatment, to check for ulcer healing and h. pylori eradication. two antral biopsies were taken a ... | 1992 | 1543813 |
| helicobacter pylori clearance in the treatment of non-ulcer dyspepsia. | one hundred and thirty north nigerian patients with non-ulcer dyspepsia were treated with tripotassium dicitrato bismuthate and amoxycillin, or antacid. symptoms resolved in 28 (33%) of bismuth and amoxycillin recipients completing the trial compared with 1 (4%) of the antacid recipients. symptomatic improvement did not relate to clearance of helicobacter pylori. | 1992 | 1543814 |
| comparison of one-day oral dosing with three bismuth compounds for the suppression of helicobacter pylori assessed by the 13c-urea breath test. | assessment of intragastric urease activity by the 13c-urea breath test was performed before and after one day of dosing with either de-noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), pepto-bismol liquid (bismuth salicylate 30 ml q.d.s.), or roter tablets (bismuth subnitrate, one tablet q.d.s.) in twelve helicobacter pylori-positive patient volunteers. there was a significant decrease in the excess of 13co2 after one day of dosing with each of the three bismuth compounds, but an ... | 1992 | 1543820 |
| factors influencing gastroduodenal mucosal prostaglandin concentrations: roles of smoking and aging. | to evaluate behavioral, demographic, clinical, and histologic variables that independently influence gastroduodenal mucosal prostaglandin concentrations. | 1992 | 1546863 |
| low biological activity of helicobacter pylori lipopolysaccharide. | lipopolysaccharide from the gastroduodenal pathogen helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. we suggest that the phosphorylation pattern and acylation in lipid a are responsible for the low biological activity. | 1992 | 1548097 |
| noninvasive detection of helicobacter pylori colonization in stomach using [11c]urea. | helicobacter pylori is associated with chronic type b gastritis. diagnosis can be made on gastric biopsy specimens and noninvasively using [13c]- or [14c]urea breath tests. both breath tests require meticulous breath collection, and false positive results are possible from urease producing oral-pharyngeal flora. we used [11c]urea, a positron-emitting radionuclide allowing dynamic imaging, to measure metabolism of urea in the stomach of biopsy documented h. pylori-positive patients. [11c]urea was ... | 1992 | 1551356 |
| assessment of enzyme detection tests useful in identification of campylobacteria. | twenty-one type or other reference strains, each representing a different campylobacter, helicobacter, or arcobacter taxon, and a reference strain of staphylococcus aureus were used to assess the reproducibility of nine enzyme detection tests used in the identification of campylobacters. for five of the tests (alkaline phosphatase, dnase, and h2s production, indoxyl acetate hydrolysis, and nitrate reduction), more than one procedure was employed to determine the most suitable method. alkaline ph ... | 1992 | 1551996 |
| increased density of helicobacter pylori on antral biopsy is associated with severity of acute and chronic inflammation and likelihood of duodenal ulceration. | an increased risk of ulcers and severity of inflammation with increased degree of helicobacter pylori (hp) infection (biological gradient) would support the hypothesis that hp causes ulcers. a blinded pathologist evaluated antral biopsies obtained at endoscopy in 903 patients. the level of hp infection was assessed on warthin starry stain, and the severity of acute and chronic inflammation on hematoxylin and eosin graded from 0 to 3. the presence of duodenal ulcers was associated with increasing ... | 1992 | 1553928 |
| serum pepsinogen i levels of gastric ulcer patients are determined by the location of the ulcer crater. | to examine the relation between gastric ulcer (gu) location and serum pepsinogen i (pgi) level, we measured this marker in 284 endoscopically proved gu patients. their ulcer locations were further divided according to johnson's criteria modified to the corpus (type 1a), gastric angle (type 1b), combined with duodenal ulcer (type 2) and prepyloric area (type 3). the number of each subset were 96, 81, 58 and 49, respectively. mean serum pgi level (99.6 +/- 44.8 ng/ml) of all gu patients showed no ... | 1992 | 1555752 |
| production of a conserved adhesin by the human gastroduodenal pathogen helicobacter pylori. | an adhesin protein with an approximate subunit molecular weight of 19,600 has been purified from the gastric pathogen helicobacter pylori. the protein was loosely associated with the cell surface and was removed by gentle stirring or shearing. released aggregates of the 19.6-kda protein were removed from suspension by ultracentrifugation and separated from contaminating membranes by washing in 1.0% sodium dodecyl sulfate (sds). the sds-insoluble protein was purified further by mono q anion-excha ... | 1992 | 1556073 |
| helicobacter pylori associated phospholipase a2 activity: a factor in peptic ulcer production? | to examine the potential role of the lipolytic enzyme phospholipase a2, produced by helicobacter pylori in ulcer formation. | 1992 | 1556229 |
| secretion of intravenously administered antibiotics in gastric juice: implications for management of helicobacter pylori. | to study whether differences in eradication rates of antibiotics may be explained by differences in secretion of antibiotics in gastric juice. | 1992 | 1556230 |
| effect of physical environment on survival of helicobacter pylori. | to determine the effects of physical conditions on survival of helicobacter pylori in aquatic environments. survival for prolonged time intervals would implicate environmental water as a possible source of infection. | 1992 | 1556231 |
| helicobacter pylori infection and duodenal ulcer disease. | | 1992 | 1556517 |
| effect of treatment of helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. a randomized, controlled study. | to determine the effect of treating helicobacter pylori infection on the recurrence of gastric and duodenal ulcer disease. | 1992 | 1558340 |
| helicobacter pylori: selection of patients for treatment. | | 1992 | 1558351 |
| current trends in the pharmacotherapy for peptic ulcer disease. | a variety of options are available for the medical treatment of peptic ulcer disease, including antacids, histamine2 receptor antagonists, omeprazole, prostaglandin analogues, and sucralfate and bismuth formulations. seventy percent to 90% of peptic duodenal and gastric ulcers will heal after 4 to 8 weeks of therapy. combination regimens using these agents have not been demonstrated to be superior to single-agent therapy. aggressive acid suppression with "high-dose" histamine2 receptor antagonis ... | 1992 | 1558429 |
| [epidemiologic characteristics of helicobacter pylori infections]. | | 1992 | 1528151 |
| antral gastritis, helicobacter pylori, and gastric mucosal sensitivity. | | 1992 | 1537506 |
| helicobacter pylori infection in patients with upper gastrointestinal symptoms in arba minch hospital: southwestern ethiopia. | a prospective study was conducted to determine the frequency of occurrence of helicobacter pylori infection in outpatients presenting with upper gastro intestinal symptoms to arba minch hospital over a one year period. four hundred and forty four patient, 309 males and 135 females, underwent upper gastro intestinal fiberoptic endoscopy between march 1989 and april 1990. the age range was 14 to 75 years (mean = 35). all 444 patients were examined and tested for infection. sixty per cent had abnor ... | 1992 | 1563364 |
| elevated risk of helicobacter pylori infection in submarine crews. | in a prospective study designed to elucidate the route of transmission of helicobacter pylori, the seroprevalence and incidence of helicobacter pylori infection was determined in the following branches of the armed forces presumed to be at increased risk of acquiring transmissible diseases by the fecal-oral or oral-oral route: german submarine crews (n = 64, mean age 26.2 years) and regular officers of the french infantry (n = 51, mean age 26.5 years) who had served for a minimum of three years. ... | 1992 | 1563394 |
| relationship of helicobacter pylori to serum pepsinogens in an asymptomatic japanese population. | a seroepidemiologic study of the prevalence of helicobacter pylori infection in japan was performed, and the relationship between serum pepsinogen i and ii levels (markers of gastritis and gastric atrophy) and h. pylori infection was investigated. four hundred and eighteen asymptomatic children and adults were studied. the prevalence of anti-h. pylori immunoglobulin g antibody increased with age. for persons born after 1950, the frequency of h. pylori infection increased at approximately 1% per ... | 1992 | 1537513 |
| igg subclass response to helicobacter pylori in patients with chronic active gastritis and duodenal ulcer. | the igg subclass response is determined by the type of bacteria producing the infection and by genetic factors of the host. patients with a helicobacter pylori infection develop a specific immune response that is mainly of the iga and igg class. we measured the igg subclass response in 20 patients with chronic active gastritis without a history of duodenal ulcer and 20 patients with chronic active gastritis and duodenal ulcer diagnosed by endoscopy and histology. a control group included 20 h. p ... | 1992 | 1561526 |
| identification and purification of a cpn60 heat shock protein homolog from helicobacter pylori. | helicobacter pylori is associated with gastritis and peptic ulcer disease in humans. we have identified a homolog of the chaperonin cpn60 family of heat shock proteins in h. pylori, referred to as hp54k. hp54k, purified from water-extractable h. pylori proteins, migrated as a single band at 54 kda by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. its native molecular mass was 740 kda; thus, hp54k apparently comprises a 14-mer. the n-terminal 33 residues of hp54k exhibited 60.6, 57.6, ... | 1992 | 1563786 |
| ultrastructural study of helicobacter pylori adherence properties in gnotobiotic piglets. | ultrastructural examination of gastric mucosa from helicobacter pylori-infected gnotobiotic piglets identified four general adherence patterns comparable to those observed in human patients. intimate associations between the bacterial and mucosal cell membranes, including cuplike invaginations and adherence pedestals, were present and were accompanied by alterations to microvilli and cell membrane morphology. | 1992 | 1563801 |
| helicobacter pylori and duodenal ulcer. evidence suggesting causation. | | 1992 | 1563322 |
| difference in expression of helicobacter pylori gastritis in antrum and body. | seven hundred seventy biopsy specimens obtained from 10 different sites in stomachs of 77 patients were examined for the presence of active chronic gastritis (acg) and helicobacter pylori to investigate the characteristics of gastritis in the antrum and body. forty-eight patients with acg at one or more sites were all h. pylori positive. h. pylori was not found in 20 patients who had chronic gastritis with no activity or in 9 patients who had histologically normal mucosa. in patients with acg in ... | 1992 | 1568567 |
| helicobacter pylori and peptic ulcers: the present position. | | 1992 | 1568643 |
| [helicobacter pylori-associated hypertrophic gastritis. imitation of ménétrier disease]. | a 42-year-old man developed giant fold gastritis that was associated with massive helicobacter pylori colonization, highly active, high-grade gastritis and severe hypoproteinemia with gastric protein-loss syndrome. histology revealed marked focal foveolar hyperplasia of the body and fundic mucosa. combination treatment with amoxicillin and omeprazole resulted in the eradication of the helicobacter pylori. concomitantly, the foveolar hyperplasia, gastritis and the giant folds regressed completely ... | 1992 | 1568688 |
| adherence and internalization of helicobacter pylori by hep-2 cells. | helicobacter pylori colonizes the mucous layer of the stomach and the surface of gastric mucous cells. although h. pylori is not generally thought of as invasive, it has been observed in the lamina propria and within vacuoles in the cytoplasm of epithelial cells. the authors report that isolates of h. pylori can enter into the cytoplasm of tissue culture epithelial cell lines such as hep-2 cells. intracellular uptake of h. pylori by hep-2 cells is rapid and appears to require both the n-acetylne ... | 1992 | 1568565 |
| drug resistance of helicobacter pylori: memorandum from a meeting at the sixth international workshop on campylobacter, helicobacter, and related organisms. | | 1992 | 1569352 |
| further evidence of the toxic effect of ammonia produced by helicobacter pylori urease on human epithelial cells. | former studies have shown that helicobacter pylori can induce vacuolation of vacuolation of epithelial cells in vitro and possibly in vivo, either by direct action of a cytotoxin or by the action of its strong urease, which breaks down the urea physiologically present in the stomach into cytotoxic ammonia. we have developed a test using hep2 cells with adherent h. pylori bacteria in order to compare the effects of an h. pylori urease-negative variant with those of its urease-positive parent stra ... | 1992 | 1563774 |
| characterization of helicobacter pylori urease mutants. | the association between helicobacter pylori, gastritis, and peptic ulcer is well established, and the association of infection with gastric cancer has been noted in several developing countries. however, the pathogenic mechanism(s) leading to disease states has not been elucidated. the h. pylori urease is thought to be a determinant of pathogenicity, since the enzyme is produced by all h. pylori clinical isolates. evidence indicates that some h. pylori strains are more cytotoxic than others, wit ... | 1992 | 1563778 |
| a comparison of diagnostic tests to determine helicobacter pylori infection. | twenty-five helicobacter pylori positive and 25 h. pylori negative subjects as defined by culture and phase contrast microscopy of antral biopsy specimens obtained from routine upper endoscopy were studied. antral biopsies were examined by rapid urease test, phase contrast microscopy, culture and histology. venous blood was tested for h. pylori specific igg antibodies by an elisa technique. within 7 days of endoscopy the patients also had a [14c]-urea breath test. the sensitivity and specificity ... | 1992 | 1571505 |
| more on pathogenic mechanisms of helicobacter pylori. | | 1992 | 1571456 |
| beta-2-microglobulin and helicobacter pylori infection in uraemic dialysed patients. | chronic gastritis in patients with chronic renal failure may have different causes and mechanisms. recent observations suggest that severe gastritis often found in uraemic patients might be related to helicobacter pylori (hp) infection. in chronic gastritis hp has been found in the mucus and on the epithelial cell surface of gastric foveolas. significant infiltration of the subepithelial gastric layer by polymorphonuclear leucocytes has been described. moreover, beta-2-microglobulin deposits hav ... | 1992 | 1571503 |
| pathologic changes of gastric mucosa colonized by helicobacter pylori. | one hundred eighty-nine consecutive gastric biopsies showing colonization by helicobacter pylori (hp) were studied. epigastric pain and bleeding were the clinical presentations in 167 cases (88.4%). major endoscopic findings were gastritis (n = 72, 38.1%) and ulceration (n = 101, 53.4%). duodenal ulcer was associated with 32 (44.4%) and 29 (28.7%) cases of gastritis and gastric ulcer, respectively. histologically, the hp-colonized gastric epithelium showed characteristic degenerative changes tha ... | 1992 | 1568749 |
| the role of helicobacter pylori in the pathogenesis of acid-peptic disease. | helicobacter pylori (h pylori) is likely the most common cause of chronic active gastritis in humans. also, h pylori has been found in up to 100% of patients with peptic ulcer disease. recent studies have shown that long-term infection by h pylori is associated with an increased risk of developing gastric carcinoma. the mechanism(s), however, by which h pylori causes gastritis or leads to the development of peptic ulcers and gastric cancer is not well understood. the prevalence of h pylori gradu ... | 1992 | 1576460 |
| mechanisms of gastric and duodenal damage and protection. | by binding to the cyclooxygenase enzyme, non-steroidal, anti-inflammatory drugs (nsaids) inhibit synthesis of prostanoids characteristic of the cell under consideration. for the gastric mucosa, the main products are prostaglandin (pg) e2 or pgi2; for platelets the main product is thromboxane. aspirin irreversibly acetylates the cyclooxygenase enzyme. consequently, it has more prolonged effects, particularly in cells like platelets, which are not rapidly turned over. prostaglandin-dependent prote ... | 1992 | 1577394 |
| helicobacter pylori and gastric ulcer therapy: reflections and uncertainties. | the relationship between helicobacter pylori (hp) and gastric ulcer therapy is examined by analyzing both the data that suggest that eradication of hp renders the gastric mucosa less susceptible to development of gastric ulcer as well as the substantial body of evidence that does not support this contention. the results reported in clinical trials with colloidal bismuth citrate, antimicrobial agents (furazolidone), and combinations of anti-ulcer and antimicrobial agents (h2-antagonist+cefixime, ... | 1992 | 1576367 |
| helicobacter pylori infection and chronic gastritis in gastric cancer. | to investigate the prevalence of helicobacter pylori associated chronic gastritis in patients with gastric cancer. | 1992 | 1577969 |
| urease activity of helicobacter pylori. | | 1992 | 1577984 |
| [relation between helicobacter pylori and intractable gastric ulcer--pas positive intramucosal mucus as an index]. | helicobacter pylori (hp) is considered to be one of the causes of gastric mucosal injury. using biopsy specimens from the gastric mucosa of patients with gastritis or gastric ulcer, the intramucosal mucus was quantified by computer image analysis to evaluate its relationship with hp. in gastric mucosa positive for hp, the mucus content within the gastric mucosa was significantly decreased. ammonia was administered based on its assumed role in decreasing the mucus content of the gastric mucosa, a ... | 1992 | 1578801 |
| [short-term therapy with high dosage omeprazole and amoxicillin for helicobacter pylori eradication. a pilot study]. | in an open study, 50 patients with helicobacter pylori-associated ulcer disease or severe functional dyspepsia were treated over one week with 2 x 40 mg omeprazole in the morning and evening preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. fourty-seven patients (ulcer disease: n = 40, functional dyspepsia: n = 7) completed the study without contravening the protocol. the proportion of helicobacter pylori eradication four weeks after cessation of study medic ... | 1992 | 1579087 |
| [polymorphism in helicobacter pylori--a key function in recurrence of infection?]. | despite the fact that helicobacter (h.) pylori is ubiquitous throughout the world, little is known at present about the source of infection and mode of transmission. person-to-person transmission may be of importance. the fact that helicobacter pylori can revert to a coccoid form stimulated speculation about its role in transmission and as a possible cause of reinfection in duodenal ulcer disease. various antibacterial agents (bismuth subcitrate 32 mg/l bismuth subsalicylate 64 mg/l, amoxicillin ... | 1992 | 1579096 |
| cholesterol binding of helicobacter pylori. | h. pylori cells grown on cholesterol-free medium adsorb cholesterol from serum, egg yolk, and vdrl reagent. the binding of cholesterol does not influence the hydrophobicity of the cells. the haemagglutinating activity is slightly diminished. the cell-bound haemolytic activity is completely inhibited. the affinity of h. pylori for cholesterol probably acts as factor of chemotaxis and adherence. | 1992 | 1576402 |
| helicobacter pylori and peptic ulcer disease in sri lanka. | the variation in the healing and the relapse rates of peptic ulcer disease has led to the search for other factors in the pathogensis of peptic ulcer disease. helicobacter pylori is believed to be responsible for these different patterns of healing. the results of a study to detect helicobacter pylori in sri lankan patients having duodenal ulcer, gastric ulcer, gastritis and non-ulcer dyspepsia are presented in this paper. the method employed was the urease test which detects the urease enzyme o ... | 1992 | 1581990 |
| helicobacter pylori: the african enigma. | | 1992 | 1582581 |
| influence of age and helicobacter pylori infection on serum pepsinogens in healthy blood transfusion donors. | in a healthy population pepsinogen a and pepsinogen c increase with advancing age. as pepsinogen a and c are raised in chronic superficial gastritis which is caused by h pylori infection, we investigated whether h pylori is responsible for the age related increase of pepsinogen a and c. in h pylori positive blood transfusion donors serum pepsinogen a (mean (sd) 73 (35) micrograms/ml v 52 (19) micrograms/ml, p much less than 0.01) and c (mean (sd) 24 (13) micrograms/ml v 10 (7) micrograms/ml, p m ... | 1992 | 1582585 |
| assay of urease-inhibiting activity in serum from children infected with helicobacter pylori. | in order to provide a basis for obtaining further information concerning the host response to helicobacter pylori urease, four assay methods for detecting urease-inhibiting activity in serum were examined. a quantitative assay, established in a cobas bio centrifugal fast analyzer and based on detection of the consumption of nadh by glutamate dehydrogenase stimulated by ammonia production, was considered most suitable for large-scale serological work. serum samples from 63 children (aged 5 to 16 ... | 1992 | 1583144 |
| new plate medium for growth and detection of urease activity of helicobacter pylori. | a new medium for detection of urease activity and isolation of helicobacter pylori is proposed. this medium, containing columbia agar base, was supplemented with isovitalex, hemin, urea, and phenol red (nonselective medium [nsm]). both bacterial growth and color change were evaluated and compared with growth in the same medium supplemented with cefsulodin, vancomycin, polymyxin b sulfate, and amphotericin b (selective medium [sm]). twenty-five recent clinical isolates and antral biopsy specimens ... | 1992 | 1583148 |
| partial characterization of a cell-free hemolytic factor produced by helicobacter pylori. | maximum cell-free hemolytic activity of helicobacter pylori cultured in broth containing 10% horse serum occurred only after the stationary phase of growth was reached, unlike many hemolysins produced by gram-negative bacteria which are active during exponential growth. this characteristic of the h. pylori hemolytic factor suggested that it might also possess protease activity. however, because no evidence of albumin degradation was found, the hemolysis by cell-free concentrates of h. pylori app ... | 1992 | 1575989 |
| helicobacter pylori and gastroduodenal disease. | helicobacter pylori infection is now recognized as the primary cause of active chronic gastritis in humans. most infected persons remain asymptomatic, but are at increased risk for the development of peptic ulcer disease and possibly gastric cancer. the pathogenesis of this infection is not well understood, but motility and urease activity are virulence factors in an animal model. the eradication of h. pylori infection is associated with resolution of gastritis and a decreased rate of duodenal u ... | 1992 | 1580578 |
| helicobacter pylori and gastritis. | | 1992 | 1587206 |
| [serological screening for helicobacter pylori. can a blood test make gastroscopy superfluous?]. | | 1992 | 1587222 |
| mechanism of gastric mucosal damage induced by ammonia. | the mechanism for helicobacter pylori-induced gastric mucosal injury remains obscure. h. pylori has high urease activity to produce ammonia from urea in the stomach. in this study, the effects of ammonia on (a) gastric mucosal integrity, (b) gastric mucosal hemodynamics, (c) mucosal cellular viability, (d) mitochondrial respiration, and (e) energy metabolism of gastric mucosal were investigated. ammonia (ph 10.3) at concentrations of greater than 125 mmol/l caused acute macroscopic gastric mucos ... | 1992 | 1587407 |
| long-term nonsteroidal anti-inflammatory drug use and gastroduodenal injury: the role of helicobacter pylori. | to evaluate the association of helicobacter pylori infection with gastroduodenal ulceration and symptoms in rheumatoid arthritis patients chronically ingesting nonsteroidal anti-inflammatory drugs (nsaids), a population-based study was performed. residents of olmsted county, minnesota, and surrounding counties, 40 years of age and over with active rheumatoid arthritis taking therapeutic dose of nsaids daily for 6 months or more were evaluated (n = 50). an endoscopic score from 0 to 5 was assigne ... | 1992 | 1587409 |
| the glycerolipid receptor for helicobacter pylori (and exoenzyme s) is phosphatidylethanolamine. | we have previously shown that helicobacter pylori specifically binds to a glycerolipid species preferentially found in the antrum of the human stomach. we now show by high-pressure liquid chromatographic analysis that this species is a form of phosphatidylethanolamine and that h. pylori specifically binds to bona fide phosphatidylethanolamine as detected by a thin-layer chromatogram overlay procedure. considerable variation in the binding of h. pylori to phosphatidylethanolamine from different s ... | 1992 | 1587616 |
| purification and characterization of the vacuolating toxin from helicobacter pylori. | a vacuolating toxin was purified to homogeneity from broth culture supernatant of the human gastric bacterium, helicobacter pylori. the procedure for isolating the toxin included ammonium sulfate precipitation, hydrophobic interactive chromatography, size exclusion chromatography, and anion exchange chromatography, which together resulted in a greater than 5000-fold purification of toxin activity. the molecular mass of the purified, denatured toxin was 87,000 +/- 320 daltons, and the native toxi ... | 1992 | 1587837 |
| evaluation of different solid media used for cultivation of helicobacter (campylobacter) pylori. | the ability of nine blood containing media to support the growth of h. pylori was compared. eighteen strains of h. pylori isolated from antral biopsies were cultivated in two dilutions, for colony counts on the media to be tested. columbia base chocolate agar without additives was found to be the best medium for growth of h. pylori. however, all other fresh blood containing media also supported the growth of this organism satisfactorily. | 1992 | 1577515 |
| helicobacter pylori eradication with doxycycline-metronidazole-bismuth subcitrate triple therapy. | triple therapy containing tetracycline hcl is currently among the most efficient combination therapies for eradication of helicobacter pylori. substitution of doxycycline for tetracycline hcl offers advantages of less frequent dosing and extrarenal excretion. in this study patients with duodenal ulcer or non-ulcer dyspepsia positive for h. pylori were randomized to either doxycycline or tetracycline hcl triple therapy in conjunction with bismuth subcitrate and metronidazole. of the 34 patients t ... | 1992 | 1589705 |
| oxyntic and antral gastritis in the people's republic of china: diagnosis and relationship to helicobacter pylori. | this study investigates the relationship between gastritis and helicobacter pylori infection in the chinese population. particular focus was placed upon the grading of gastritis, using the recently developed "sydney system." five diagnostic procedures were used to establish h. pylori status, all of which were found to be highly sensitive and specific. histological chronic gastritis was reported in 93/108 (86.1%) of the patients examined, h. pylori infection being present in 73/93 (78.5%), and in ... | 1992 | 1590312 |
| metronidazole resistance among helicobacter pylori strains in malaysia. | | 1992 | 1590330 |
| role of metronidazole resistance in therapy of helicobacter pylori infections. | susceptibility to metronidazole was determined by disk diffusion tests for 559 strains of helicobacter pylori isolated from patients. the overall metronidazole resistance was 26%. in males metronidazole-resistant strains made 18% of all h. pylori strains, and in females the corresponding figure was 40% (p less than 0.001). mics of metronidazole were determined for h. pylori strains from 86 patients undertaking triple therapy, i.e., treatment with colloidal bismuth subcitrate, amoxicillin, and me ... | 1992 | 1590683 |
| helicobacter pylori infection: comparison among four different therapeutic regimens. | helicobacter pylori is both virulent and pathogenic, yet it is not clear what is the best way to treat the infection. this study compares the ability of 4 regimens of colloidal bismuth subcitrate (cbs) 120 mg q.i.d. for 4 weeks, combined with one or two antibiotics, to eradicate helicobacter pylori and assesses the outcome of eradication on antral gastritis and on symptoms of non-ulcer dyspepsia in 140 consecutive subjects (44 duodenal ulcers and 96 non ulcer dyspepsia). endoscopy with antral bi ... | 1992 | 1589252 |