| role of emerging campylobacter species in inflammatory bowel diseases. | the gut microbiota is a central player in the etiology of inflammatory bowel diseases. as such, there is intense scientific interest in elucidating the specific group/s of bacteria responsible for driving barrier damage and perpetuating the chronic inflammation that results in disease. because of their ability to colonize close to the surface of the host intestinal epithelium, mucosa-associated bacteria are considered key players in the initiation and development of both crohn's disease and ulce ... | 2014 | 24874462 |
| psychometric scores and persistence of irritable bowel after campylobacter concisus infection. | gastroenteritis with campylobacter concisus is an emerging infection, but the risk of irritable bowel syndrome (ibs) following it is unknown. | 2014 | 24646319 |
| tools to covisualize and coanalyze proteomic data with genomes and transcriptomes: validation of genes and alternative mrna splicing. | direct links between proteomic and genomic/transcriptomic data are not frequently made, partly because of lack of appropriate bioinformatics tools. to help address this, we have developed the pg nexus pipeline. the pg nexus allows users to covisualize peptides in the context of genomes or genomic contigs, along with rna-seq reads. this is done in the integrated genome viewer (igv). a results analyzer reports the precise base position where lc-ms/ms-derived peptides cover genes or gene isoforms, ... | 2014 | 24152167 |
| campylobacter concisus and exotoxin 9 levels in paediatric patients with crohn's disease and their association with the intestinal microbiota. | there is mounting evidence for a possible role for campylobacter concisus in crohn's disease (cd). however, the pathogenic potential of c. concisus remains disputed due to its presence in healthy subjects. it is documented that genetic diversity exists within this species, with some strains possessing putative virulence determinants such as exotoxin 9/dnai that may enable them to persist intracellularly in host cells. in order to clarify this, we employed real-time pcr to determine c. concisus a ... | 2014 | 24105841 |
| clinical manifestations of campylobacter concisus infection in children. | there is only sparse information about the clinical impact of campylobacter concisus infections in children. | 2013 | 23743545 |
| comparison of polycarbonate and cellulose acetate membrane filters for isolation of campylobacter concisus from stool samples. | one thousand seven hundred ninety-one diarrheic stool samples were cultivated for campylobacter spp. we found a high prevalence of campylobacter concisus with use of a polycarbonate filter (n = 114) compared to a cellulose acetate filter (n = 79) (p < .0001). the polycarbonate filter is superior to the commonly used cellulose acetate filter for detection of c. concisus. | 2013 | 23743174 |
| the role of epsilonproteobacteria in children with gastroenteritis. | a polymerase chain reaction-denaturing gradient gel electrophoresis method was used to examine 50 stool samples from children in belgium with gastroenteritis for an extensive range of epsilonproteobacteria species. during the 3-month study period, campylobacter concisus was the most common species. our observations suggest that c. concisus displays similar microbiologic and clinical features as campylobacter jejuni. | 2013 | 23624432 |
| oesophageal bacterial biofilm changes in gastro-oesophageal reflux disease, barrett's and oesophageal carcinoma: association or causality? | barrett's oesophagus (bo) and gastro-oesophageal reflux disease (gerd) are precursors of oesophageal adenocarcinoma (oac). there is an oesophageal biofilm, which changes in disease, but its role in aetiopathogenesis remains unclear. | 2013 | 23600758 |
| a culture-independent sequence-based metagenomics approach to the investigation of an outbreak of shiga-toxigenic escherichia coli o104:h4. | identification of the bacterium responsible for an outbreak can aid in disease management. however, traditional culture-based diagnosis can be difficult, particularly if no specific diagnostic test is available for an outbreak strain. | 2013 | 23571589 |
| high incidence of campylobacter concisus in gastroenteritis in north jutland, denmark: a population-based study. | the incidence of non-thermophilic campylobacter species was assessed in an unselected population-based study in a mixed urban and rural community in north jutland, denmark. in a 2-year study period, 11,314 faecal samples from 8302 patients with gastroenteritis were cultured with supplement of the filter method. we recovered a high incidence of campylobacter concisus (annual incidence 35/100,000 inhabitants), almost as high as the common campylobacter jejuni/coli. in contrast, there was a very lo ... | 2013 | 22512739 |
| ibd-what role do proteobacteria play? | the gastrointestinal microbiota has come to the fore in the search for the causes of ibd. this shift has largely been driven by the finding of genetic polymorphisms involved in gastrointestinal innate immunity (particularly polymorphisms in nod2 and genes involved in autophagy) and alterations in the composition of the microbiota that might result in inflammation (so-called dysbiosis). microbial diversity studies have continually demonstrated an expansion of the proteobacteria phylum in patients ... | 2012 | 22349170 |
| gastroenteritis caused by campylobacter concisus. | we describe a case of gastroenteritis caused by campylobacter concisus. the pathogenic potential of c. concisus has yet to be elucidated. recent studies indicate an association with enteric disease in immunocompromised patients and inflammatory bowel disease in children. molecular identification methods may be necessary for identifying certain campylobacter species because of phenotypic similarity. | 2012 | 22301611 |
| azathioprine, mercaptopurine, and 5-aminosalicylic acid affect the growth of ibd-associated campylobacter species and other enteric microbes. | campylobacter concisus is a bacterium that is associated with inflammatory bowel disease (ibd). immunosuppressive drugs including azathioprine (aza) and mercaptopurine (mp), and anti-inflammatory drug such as 5-aminosalicylic acid (5-asa) are commonly used to treat patients with ibd. this study aimed to examine the effects of aza, mp, and 5-asa on the growth of ibd-associated bacterial species and to identify bacterial enzymes involved in immunosuppressive drug metabolism. a total of 15 bacteria ... | 2017 | 28424670 |
| incidence of campylobacter concisus and c. ureolyticus in traveler's diarrhea cases and asymptomatic controls in nepal and thailand. | campylobacter concisus and c. ureolyticus have emerged in recent years as being associated with acute and prolonged gastroenteritis and implicated in the development of inflammatory bowel diseases. however, there are limited data on the prevalence of these microorganisms in southeast asia. in this study, 214 pathogen-negative stool samples after laboratory examination for common enteric pathogens to include c. jejuni and c. coli by culture from two case-control traveler's diarrhea (td) studies c ... | 2017 | 28824712 |
| campylobacter concisus genomospecies 2 is better adapted to the human gastrointestinal tract as compared with campylobacter concisus genomospecies 1. | campylobacter concisus was previously shown to be associated with inflammatory bowel disease including crohn's disease (cd) and ulcerative colitis (uc). c. concisus has two genomospecies (gs). this study systematically examined the colonization of gs1 and gs2 c. concisus in the human gastrointestinal tract. gs1 and gs2 specific polymorphisms in 23s rrna gene were identified by comparison of the 23s rrna genes of 49 c. concisus strains. two newly designed pcr methods, based on the polymorphisms o ... | 2017 | 28824443 |
| complete genome sequence of campylobacter concisus atcc 33237(t) and draft genome sequences for an additional eight well-characterized c. concisus strains. | we report the complete genome sequence of the campylobacter concisus type strain atcc 33237 and the draft genome sequences of eight additional well-characterized c. concisus strains. c. concisus has been shown to be a genetically heterogeneous species, and these nine genomes provide valuable information regarding the diversity within this taxon. | 2017 | 28729281 |
| analysis of a dual domain phosphoglycosyl transferase reveals a ping-pong mechanism with a covalent enzyme intermediate. | phosphoglycosyl transferases (pgts) are integral membrane proteins with diverse architectures that catalyze the formation of polyprenol diphosphate-linked glycans via phosphosugar transfer from a nucleotide diphosphate-sugar to a polyprenol phosphate. there are two pgt superfamilies that differ significantly in overall structure and topology. the polytopic pgt superfamily, represented by mray and weca, has been the subject of many studies because of its roles in peptidoglycan and o-antigen biosy ... | 2017 | 28630348 |
| campylobacter concisus as the etiologic agent of gastrointestinal diseases. | a number of reports on the pathogenic influence of campylobacter concisus on the human body and its role in many diseases of the gastrointestinal system, including gastroesophageal reflux disease, barrett's esophagus and inflammatory bowel disease, have appeared lately. campylobacter concisus is a gram negative bacteria which requires an anaerobic environment or microaerophilic environment with hydrogen for growth and is therefore difficult to culture. due to this difficulty, the rate of infecti ... | 2017 | 28397447 |