| [comparative studyof prototype and vaccinating strains of junin virus (e.h.f.)]. | | 1970 | 5504270 |
| [evaluation of a method of purification of junin virus]. | | 1970 | 5527262 |
| [a simple method of obtaining a complement fixation antigen of junin virus]. | | 1970 | 5527263 |
| [immunization against argentinian hemorrhagic fever using an attenuated strain of junin virus. iv. evaluation of clinical and immunological results]. | | 1970 | 5527264 |
| [comparative study of radiotype and vaccinating strains of junin virus (e.h.f.)]. | | 1970 | 5527265 |
| [establishment and characteristics of a subline of vero cells persistently infected with junin virus]. | | 1970 | 5527266 |
| [chromosome changes caused by junin virus in a mixed culture]. | | 1970 | 5527267 |
| [chromosome changes caused by junin virus in a mixed culture]. | | 1970 | 5527656 |
| frequency of rodents in habitats near pergamino, argentina, as related to junín virus. | | 1971 | 5553268 |
| [level of antibodies against junin virus in a group of laboratory personnel]. | | 1971 | 5566441 |
| tolerance to junin virus in thymectomized mice. | | 1967 | 5591573 |
| growth of junin virus, the etiological agent of argentinian hemorrhagic fever, in cell cultures. | | 1967 | 5591575 |
| [immunological studies with junin virus. i. formation of antibodies in guinea pigs inoculated with live viruses]. | | 1967 | 5600651 |
| [immunological studies with junin virus. i. formation of antibodies in guinea pigs inoculated with live viruses]. | | 1967 | 5600651 |
| [immunological studies with the junin virus. ii. acquired immunity in guinea pigs with a formol-inactivated virus]. | | 1967 | 5619831 |
| [immunological studies with the junin virus. ii. acquired immunity in guinea pigs with a formol-inactivated virus]. | | 1967 | 5619831 |
| purification of junin virus by an aqueous biphasic polymer system. | | 1968 | 5684207 |
| [lipid changes in the serum of guinea pigs infected with junin virus (argentinian hemorrhagic fever)]. | | 1968 | 5738395 |
| [lipid changes in the serum of guinea pigs infected with junin virus (argentinian hemorrhagic fever)]. | | 1968 | 5738395 |
| [size of junin virus (argentinian hemorrhagic fever)]. | | 1968 | 5738400 |
| [immunization against argentina hemorrhagic fever using a strain attenuated junin virus. ii. imunization of volunteers, clinical and laboratory analysis]. | | 1969 | 5795134 |
| junin virus multiplication in thymectomized mice. effect of thymus and immunocompetent cells grafting. | | 1969 | 5795747 |
| [immunization against argentina hemorrhagic fever using a strain of attenuated junin virus. 3. serological reactions in volunteers]. | | 1969 | 5802652 |
| [experimental hemorrhagic fever in guinea pigs (junín virus). contagion and elimination of the virus]. | | 1965 | 5844726 |
| [experimental hemorrhagic fever in guinea pigs (junín virus). contagion and elimination of the virus]. | | 1965 | 5844726 |
| [antigenic relationships of 7 strains of junín virus isolated in epidemics in different years]. | | 1965 | 5861768 |
| [sub-cellular localization of the junín virus in the brain of suckling rats. study of infectivity]. | | 1965 | 5861770 |
| [electrophoresis of the serum proteins of guinea pigs inoculated with junín virus (on paper and polyacrylamide gel)]. | | 1965 | 5861780 |
| [electrophoresis of the serum proteins of guinea pigs inoculated with junín virus (on paper and polyacrylamide gel)]. | | 1965 | 5861780 |
| [experimental hemorrhagic fever. histaminemia in guinea pigs inoculated with junín virus]. | | 1965 | 5888139 |
| [experimental hemorrhagic fever. histaminemia in guinea pigs inoculated with junín virus]. | | 1965 | 5888139 |
| [study carried out with the sera of the argentine hemorrhagic fever epidemic (1963) which did not present serologic conversion for junin virus]. | | 1966 | 5962723 |
| [electron microscopy of the cytopathological action of the junín virus in the guinea pib lymph node]. | | 1966 | 5981793 |
| [experimental hemorrhagic fever (junin virus). blood sugar, lactic acid in the blood, serum glycolysis and osmotic fragility of erythrocytes]. | | 1966 | 5987602 |
| [electrolyte changes in the blood of guinea pigs infected with junin virus]. | | 1966 | 5987610 |
| [electrolyte changes in the blood of guinea pigs infected with junin virus]. | | 1966 | 5987610 |
| characteristics of junin virus. etiological agent of argentine hemorrhagic fever. | | 1966 | 5989313 |
| [experimental infection of a south american primate, the cebus sp, with xj strain of junin virus]. | | 1983 | 6088938 |
| [responsibility of serological variants in chronic junin virus infection]. | | 1983 | 6088939 |
| [analysis of chromosome aberrations and sister chromatid exchanges in human lymphocyte cultures infected with junin virus (strain xj-clone 3)]. | | 1983 | 6088940 |
| [lethality produced by an attenuated junin virus in suckling mice]. | | 1983 | 6088941 |
| the guinea pig model for argentine hemorrhagic fever. | guinea pigs infected by the peripheral route with the xj pathogenic strain of junin virus showed viscerotropism mainly in reticulo-phagocytic rich organs. by immunofluorescence, heavy infection of reticular-phagocytic cells was demonstrated, supporting the leading role of these cell types. absence of neurotropism was demonstrated by the inability to recover infectious virus, as well as the absence of antigens, immunoglobulins, or 3rd component of complement deposits, in cells, vessels, or mening ... | 1984 | 6095695 |
| the guinea pig model for argentine hemorrhagic fever. | guinea pigs infected by the peripheral route with the xj pathogenic strain of junin virus showed viscerotropism mainly in reticulo-phagocytic rich organs. by immunofluorescence, heavy infection of reticular-phagocytic cells was demonstrated, supporting the leading role of these cell types. absence of neurotropism was demonstrated by the inability to recover infectious virus, as well as the absence of antigens, immunoglobulins, or 3rd component of complement deposits, in cells, vessels, or mening ... | 1984 | 6095695 |
| replication of junin virus in the presence of tunicamycin. | in the presence of tunicamycin (tm), an antibiotic which inhibits glycosylation, junin virus-infected cells released 70% as much virus as control cultures, as measured by [35s]-methionine appearing in a sucrose gradient virus particle fraction. in this same fraction, the incorporation of [14c]-glucosamine was inhibited 85% by tm, accompanied by a dramatic decrease in the envelope glycoprotein, gp38, and a marked decrease in virus infectivity. these results indicate that the presence of gp38 on t ... | 1984 | 6096295 |
| [rat-junin virus model: a virulence indicator]. | | 1983 | 6099861 |
| [suckling guinea pigs as a differential indicator of the virulence of attenuated strains of junin virus]. | | 1984 | 6100499 |
| [suckling guinea pigs as a differential indicator of the virulence of attenuated strains of junin virus]. | | 1984 | 6100499 |
| [inhibition of the production of infectious particles in cells infected with junín virus in the presence of tunicamycin]. | the antibiotic tunicamycin, an inhibitor of glycoprotein synthesis, suppressed junin virus multiplication in vero cells. no infectious virus was formed if tunicamycin was added, at a concentration of 1 microgram/ml, immediately after virus adsorption and remained up to the end of the replicative cycle. tunicamycin added at 24,48 or 72 hours p.i. immediately stopped virus synthesis. the effect was irreversible. virus grown in the presence or absence of tunicamycin and labelled with 3h-uridine was ... | 1982 | 6101002 |
| [differentiation among strains of junín virus by intraperitoneal infection in the rat]. | the 2-day-old rat is known to resist intracerebral infection with the xj prototype strain of junin virus, but 95-100% mortality results when infected with the attenuated xjc13 strain. when this animal was inoculated by intraperitoneal route, behaviour was diametrically opposite: the xj strain proved lethal, while de xjc13 led to low mortality. studies on mortality, virus titer in different organs, and anti-viral humoral response in 2-day-old rats infected with junin virus strains were carried ou ... | 1984 | 6101033 |
| [lack of viral persistence in 2 cebus sp]. | two cebus sp surviving acute junin virus infection, one after intramuscular inoculation with pathogenic xj and the other after intracerebral inoculation with xj clone 3, failed to exhibit persistent infection. although treatment with immunosuppressive drugs was carried out, no junin virus was detected in blood or organs in spite of blind passages in mice for the former as well as cocultivation with permissive vero cells for the latter. viremia was also ruled out by immunofluorescence on bhk/21 c ... | 1984 | 6101036 |
| [effect of the host cells in the crossed neutralization reactions between junín and tacaribe viruses ]. | it has been previously reported that guinea pigs inoculated with tacaribe virus grown in suckling mouse brain, develop specific anti-junín neutralizing antibodies (na) after 45 days of infection and a typical secondary response after junín virus challenge. since in these experiments both viruses were grown in suckling mouse brain doubt was raised about the specificity of na, considering the possibility that they were raised against host-cell antigens. in order to test this interpretation the fol ... | 1984 | 6101038 |
| [effect of the host cells in the crossed neutralization reactions between junín and tacaribe viruses ]. | it has been previously reported that guinea pigs inoculated with tacaribe virus grown in suckling mouse brain, develop specific anti-junín neutralizing antibodies (na) after 45 days of infection and a typical secondary response after junín virus challenge. since in these experiments both viruses were grown in suckling mouse brain doubt was raised about the specificity of na, considering the possibility that they were raised against host-cell antigens. in order to test this interpretation the fol ... | 1984 | 6101038 |
| [effect of various schedules of cyclophosphamide administration on the mortality of the adult mouse infected with junín virus]. | the object of this paper was to determine the influence of cyclophosphamide immunosuppression on the mortality of 40-45 day old balb/c mice infected intracerebrally with a pathogenic strain of junin virus, using different administration schedules. up to 200 mg/kg of cyclophosphamide were not toxic. results show that, unlike in other experimental models, three or four 50 mg/kg cyclophosphamide doses given both before and after viral infection were required to break-down resistance to junin virus ... | 1984 | 6101041 |
| [features of infection in hamsters by junín virus]. | suckling hamsters infected with three low passaged strains of junin virus by intracerebral route developed a non differentiated illness with about 7 log of virus replication in the brain after which they either died between 6 and 19 days post inoculation or developed cf antibodies. even in suckling hamsters and suckling mice gave similar results for viral titration, isolation attempts were less successful in hamsters. the young hamster response was characterized by a severe neurological disease ... | 1983 | 6101062 |
| [induction of heat-sensitive mutants of junín virus using 5-fluorouracil]. | this paper presents results concerning production, selection and isolation of conditionally lethal mutants of junin virus. two temperature sensitive (ts) mutants of junin virus, xjcl3 strain, were isolated from a virus population that had been mutagenized with 5-fluorouracil (5-fu). a study of the behaviour of wild-type virus over a range of temperature from 34 degrees c to 40 degrees c was done. in vero cells, the initial cloned junin virus stock gave very turbid plaques at 34 degrees c, more c ... | 1983 | 6101063 |
| [detection of laboratory infections caused by junín virus using the neutralization and immunofluorescence technics comparatively]. | to study junin virus infection among laboratory workers and to compare immunofluorescence and neutralization tests, blood samples were taken from 48 individuals, of which 42 were considered high risk personnel. none of the 16 low risk workers exhibited antibodies. neutralizing antibodies were detected in 15 high risk laboratory workers. nine of the latter were already known to carry antibodies from a previous survey in 1978. titers detected were either at previous levels or slightly higher. of t ... | 1983 | 6101064 |
| [development of the infection in guinea pigs infected with the attenuated variant xjo of junín virus]. | as previously shown, the xjo variant of junin virus (jv) is attenuated and elicits in guinea pigs a lasting humoral response and resistance to the challenge with xj pathogenic strain, during at least three months. in this paper the long term evolution of guinea pigs inoculated with xjo by im route was studied. ten animals were infected with 10(3) pfu of xjo at day 0 (group i) and an other 10, at days 0 and 77 (group ii). another 30 guinea pigs were inoculated with 10(2) pfu at day 0 (group iii) ... | 1983 | 6101069 |
| [development of the infection in guinea pigs infected with the attenuated variant xjo of junín virus]. | as previously shown, the xjo variant of junin virus (jv) is attenuated and elicits in guinea pigs a lasting humoral response and resistance to the challenge with xj pathogenic strain, during at least three months. in this paper the long term evolution of guinea pigs inoculated with xjo by im route was studied. ten animals were infected with 10(3) pfu of xjo at day 0 (group i) and an other 10, at days 0 and 77 (group ii). another 30 guinea pigs were inoculated with 10(2) pfu at day 0 (group iii) ... | 1983 | 6101069 |
| [infection of new world primates with junín virus. iv. aotus trivirgatus]. | owl monkeys (aotus trivirgatus) were inoculated with xj, a pathogenic strain of junin virus, seeking new animal models for argentine hemorrhagic fever. nine monkeys were inoculated intramuscularly with 30 or 300,000 tcid50 of junin virus. hematological and virological studies showed no alteration in blood elements such as red cell, reticular cell and platelets, up to 28 days after inoculation. hemoglobin and hematocrit determinations also remained constant. however, significant neutropenia was s ... | 1983 | 6101070 |
| [infection of new world primates with junín virus. iv. aotus trivirgatus]. | owl monkeys (aotus trivirgatus) were inoculated with xj, a pathogenic strain of junin virus, seeking new animal models for argentine hemorrhagic fever. nine monkeys were inoculated intramuscularly with 30 or 300,000 tcid50 of junin virus. hematological and virological studies showed no alteration in blood elements such as red cell, reticular cell and platelets, up to 28 days after inoculation. hemoglobin and hematocrit determinations also remained constant. however, significant neutropenia was s ... | 1983 | 6101070 |
| [infection in rats by the intraperitoneal route with junín virus]. | the susceptibility of the rat, infected at various ages by intraperitoneal route with the xj prototype strain of junin virus was studied two day-old animals showed maximum mortality, being the most suitable dose 10(3) ld50. antiviral humoral response at 35 days pi was tested in survivors of all ages. highest neutralizing antibody titers were found in those infected up to 4 days of age. this host behaves quite differently when infected by intracerebral route with the same xj strain. | 1983 | 6101071 |
| [experimental infection of guinea pigs with tacaribe virus: effect on the functioning of the immunocompetent system]. | tacaribe virus is the member most closely related to junín virus within the tacaribe complex. it has been demonstrated that both viruses are indistinguishable by complement-fixation, due to the high cross-reactivity. however, adult guinea pigs are highly sensitive to infection with the xj pathogenic strain of junín virus whereas tacaribe virus is nonpathogenic for this species. furthermore this last virus protects them against junín virus. the xj strain reduces the immune response of guinea pigs ... | 1981 | 6101101 |
| [experimental infection of guinea pigs with tacaribe virus: effect on the functioning of the immunocompetent system]. | tacaribe virus is the member most closely related to junín virus within the tacaribe complex. it has been demonstrated that both viruses are indistinguishable by complement-fixation, due to the high cross-reactivity. however, adult guinea pigs are highly sensitive to infection with the xj pathogenic strain of junín virus whereas tacaribe virus is nonpathogenic for this species. furthermore this last virus protects them against junín virus. the xj strain reduces the immune response of guinea pigs ... | 1981 | 6101101 |
| [effect of cyclophosphamide on experimental infection of rats with 2 strains of the junin virus]. | the course of viral infection in rats of several ages after intracerebral inoculation with two strains of junin virus, as well as the effect of an immunosuppressor was studied. the survival rate in 2-day-old rats was 95%, which fell to 45% in cyclophosphamide-treated infected animals (figure 1a). however, barely 5% of these rats inoculated with the xjcl3 strain survived, while the cyclophosphamide suppressive treatment increased the rate to 36% (figure 1b). this contrasting behaviour suggested t ... | 1981 | 6101102 |
| development of specific immune response in mice infected with junin virus. | different parameters of specific immune response involved in the resistance to intracerebral junin virus (jv) infection were studied in adult balb/c mice. the relationship of virus replication to production of antiviral antibodies, to occurrence of cytotoxic t cells and to development of delayed-type hypersensitivity response was evaluated. spleen cytotoxic t cells were assayed by 51cr-release method on virus-infected h2 compatible targets. effector t cells were detected on day 2, reached peak c ... | 1982 | 6127015 |
| junin virus infection of calithrix jacchus: haematological findings. | haematological changes produced by experimental junin virus infection of a platyrrhine monkey, callithrix jacchus were studied. normocytic and normochromic anaemia appeared after 7 days post infection (p. i.), and increased steadily until day 21 p. i. reticulocytes and circulating erythroblasts were elevated during the anaemia, reached a peak on day 7 p. i., and disappeared later. platelets and leukocytes showed a significant decrease from days 14 and 18 p. i., respectively. these alterations co ... | 1982 | 6127935 |
| junin virus infection of calithrix jacchus: haematological findings. | haematological changes produced by experimental junin virus infection of a platyrrhine monkey, callithrix jacchus were studied. normocytic and normochromic anaemia appeared after 7 days post infection (p. i.), and increased steadily until day 21 p. i. reticulocytes and circulating erythroblasts were elevated during the anaemia, reached a peak on day 7 p. i., and disappeared later. platelets and leukocytes showed a significant decrease from days 14 and 18 p. i., respectively. these alterations co ... | 1982 | 6127935 |
| action of antithymocyte serum on junin virus infection in rats. | two-day-old rats resistant to intracerebral (i.c.) infection with xj strain of junin virus (jv), were rendered sensitive to jv by treatment with antithymocyte serum (ats). the mortality reached 80%, the virus titres in brain were higher and the serum neutralizing antibodies dropped but brain lesions were absent throughout. the same host was susceptible to xjcl3 strain infection, which induced lethal encephalitis manifested by severe necrotic foci in cerebellum. ats treatment conferred significan ... | 1983 | 6140833 |
| importance of dose of neutralising antibodies in treatment of argentine haemorrhagic fever with immune plasma. | p6 a retrospective study outcome in patients with argentine haemorrhagic fever was associated with the amount of neutralising antibodies against junin virus present in the transfused units of immune plasma. low doses of neutralising antibodies were associated with higher mortality. a prospective study gave comparable results. a dose of no less than 3000 therapeutic units of neutralising antibodies per kg body weight is recommended. it is also suggested that the lack of effectiveness of immune pl ... | 1984 | 6146809 |
| modification of junin virus neutropism in the guinea pig model. | virulent and attenuated junin virus (jv) strains have been employed to study the influence of virus passage history on the neurotropism for guinea pigs. five i.p. successive passages (p1-p5) of the pathogenic jv-xj strain and of the attenuated xjo variant were performed in guinea pig spleen. viral titrations of organ suspensions were made through p1-p5 passages. the xj strain produced a widespread infection in p1 guinea pigs with viral dissemination to all organs except brain, in p5 animals the ... | 1984 | 6147995 |
| modification of junin virus neutropism in the guinea pig model. | virulent and attenuated junin virus (jv) strains have been employed to study the influence of virus passage history on the neurotropism for guinea pigs. five i.p. successive passages (p1-p5) of the pathogenic jv-xj strain and of the attenuated xjo variant were performed in guinea pig spleen. viral titrations of organ suspensions were made through p1-p5 passages. the xj strain produced a widespread infection in p1 guinea pigs with viral dissemination to all organs except brain, in p5 animals the ... | 1984 | 6147995 |
| nasal and intrathalamic inoculations of primates with tacaribe virus: protection against argentine hemorrhagic fever and absence of neurovirulence. | callithrix jacchus marmosets were inoculated by different routes with two stocks of tacaribe virus, one from suckling mouse brain and another from human diploid mrc5 cells. all 12 primates inoculated by nasal route developed neutralizing serum antibodies without any clinical signs. all 6 primates receiving the mouse brain-tacaribe virus were protected against lethal challenge with pathogenic xj strain of junin virus, while protection was also conferred in 4 out of 6 primates receiving the diploi ... | 1984 | 6148851 |
| nasal and intrathalamic inoculations of primates with tacaribe virus: protection against argentine hemorrhagic fever and absence of neurovirulence. | callithrix jacchus marmosets were inoculated by different routes with two stocks of tacaribe virus, one from suckling mouse brain and another from human diploid mrc5 cells. all 12 primates inoculated by nasal route developed neutralizing serum antibodies without any clinical signs. all 6 primates receiving the mouse brain-tacaribe virus were protected against lethal challenge with pathogenic xj strain of junin virus, while protection was also conferred in 4 out of 6 primates receiving the diploi ... | 1984 | 6148851 |
| passive transfer protection against junin virus in cyclophosphamide-suppressed mice. | | 1984 | 6148861 |
| lymphatic tissue in argentine hemorrhagic fever. pathologic features. | spleen and lymph nodes from seven fatal cases of argentine hemorrhagic fever were studied by light and electron microscopy and by immunofluorescent techniques. in addition, junin virus infectivity was determined. destruction of splenic white pulp and of lymph node cortex was observed. the ultrastructural study showed a characteristic cytopathic effect on the macrophages with presence of intracisternal virus-like particles and occasional virions budding from the plasma membrane. the immunofluores ... | 1980 | 6154445 |
| biological activities of junin virus proteins. ii. complement-fixing polypeptides associated with the soluble antigen and purified virus particles. | in the junin virus-infected cell, there is a soluble antigen (sag), which we have detected by complement fixation. page of purified sag revealed two polypeptides with molecular weights of 20,000 and 25,000. an antigenically identical component, which was demonstrated by complement fixation and immunodiffusion tests and which had the same electrophoretic profile as sag, was found after proteolytic breakdown of purified virions. sag is an internal component of the virion, since it is unable to sti ... | 1980 | 6162824 |
| [persistent infection of mouse cells with junin virus: participation of interferon]. | | 1980 | 6163063 |
| induction of rna polymerase ii activity in junin virus-infected cells. | nuclear involvement of the host cell in junin virus (jv) replication was studied. alpha-amanitin was shown to inhibit jv yield, and rna synthesis in cell nuclei was found to be augmented during the eclipse period. jv infection exerted a selective effect on cellular rna polymerase activities, when measured in purified infected nuclei. rna polymerase i was inhibited, but rna polymerase ii was stimulated. these data support the hypothesis that rna polymerase ii is involved in arenavirus replication ... | 1981 | 6173349 |
| [interferon in experimental infection with junin virus]. | | 1981 | 6178929 |
| alteration of blood coagulation and complement system in neotropical primates infected with junin virus. | the neotropical primate callithrix jacchus infected with junin virus presented an acute disease with hematological and neurological manifestations and died 17 to 24 days after infection. this picture is similar to that of human argentine hemorrhagic fever (ahf). blood coagulation and complement studies were performed in ten c jacchus animals inoculated with 10(3) tcid50 of junin virus, the prototype pathogenic xj strain. four monkeys were used as normal controls. infected monkeys and normal cont ... | 1983 | 6197506 |
| alteration of blood coagulation and complement system in neotropical primates infected with junin virus. | the neotropical primate callithrix jacchus infected with junin virus presented an acute disease with hematological and neurological manifestations and died 17 to 24 days after infection. this picture is similar to that of human argentine hemorrhagic fever (ahf). blood coagulation and complement studies were performed in ten c jacchus animals inoculated with 10(3) tcid50 of junin virus, the prototype pathogenic xj strain. four monkeys were used as normal controls. infected monkeys and normal cont ... | 1983 | 6197506 |
| endogenous interferon in argentine hemorrhagic fever. | the induction of endogenous interferon (ifn) was studied in 28 cases of argentine hemorrhagic fever (ahf), a severe systemic disease caused by junin virus. serum samples were taken daily during the acute period, both before and after administration of immune plasma. this form of treatment has been found to reduce mortality when given early in the course of ahf. high titers of circulating ifn were present in the serum samples taken before treatment. ifn titers drastically dropped after transfusio ... | 1984 | 6232326 |
| protection of guinea pigs inoculated with tacaribe virus against lethal doses of junin virus. | guinea pigs were protected against lethal doses of junin virus by a previous inoculation with tacaribe virus. fourteen guinea pigs were infected with 10(6) 50% lethal doses (ld50) of tacaribe virus and superinfected 45 days later with 10(3) ld50 of junin virus. appropriate control groups for both infections were also studied. the replication of junin virus was impaired, as no virus was isolated from blood and organs of animals killed on days 9 and 11 after infection. high levels of neutralizing ... | 1980 | 6245155 |
| protection of guinea pigs inoculated with tacaribe virus against lethal doses of junin virus. | guinea pigs were protected against lethal doses of junin virus by a previous inoculation with tacaribe virus. fourteen guinea pigs were infected with 10(6) 50% lethal doses (ld50) of tacaribe virus and superinfected 45 days later with 10(3) ld50 of junin virus. appropriate control groups for both infections were also studied. the replication of junin virus was impaired, as no virus was isolated from blood and organs of animals killed on days 9 and 11 after infection. high levels of neutralizing ... | 1980 | 6245155 |
| immunosuppression in experimental junin virus infection of mice. | the effects of cyclophosphamide (cy), anti-mouse thymocyte sera, oxisuran, and cytosine arabinoside were evaluated in adult and newborn mice infected with junin virus. treatment with cy was the most effective, adult mice, which are not normally susceptible to intracerebral infection with 10(3) ld50 of junin virus, were rendered susceptible by treatment with an adequate dose and schedule of cy. however, cy-treated newborn mice were protected from death. this animal model may be suitable for use i ... | 1980 | 6246026 |
| in vitro inactivation of complement by a serum factor present in junin-virus infected guinea-pigs. | a serum factor(s) of guinea-pigs infected with junin virus, the etiological agent of argentine haemorrhagic fever, is endowed with a potent anticomplementary activity. it is resistant to heat (56 degrees, 30 min) and elutes from a sephadex g-200 column between albumin and haemoglobin. it is ineffective in the presence of edta or egta and does not sediment at 82,000 g. it has no direct effect on c4 unless functional cl is present. however, it induces cl activation that consumes c4 haemolytic acti ... | 1980 | 6247264 |
| in vitro inactivation of complement by a serum factor present in junin-virus infected guinea-pigs. | a serum factor(s) of guinea-pigs infected with junin virus, the etiological agent of argentine haemorrhagic fever, is endowed with a potent anticomplementary activity. it is resistant to heat (56 degrees, 30 min) and elutes from a sephadex g-200 column between albumin and haemoglobin. it is ineffective in the presence of edta or egta and does not sediment at 82,000 g. it has no direct effect on c4 unless functional cl is present. however, it induces cl activation that consumes c4 haemolytic acti ... | 1980 | 6247264 |
| biological properties of junin virus proteins. i. identification of the immunogenic glycoprotein. | purified junin virus was disrupted by nonionic detergent treatment (triton x-100), and subviral components were separated by ultracentrifugation. only the soluble fraction, containing all of the major glycoprotein (mol.wt. 38,000), induced the formation of neutralizing antibodies in laboratory animals and protected them against subsequent challenge with live virus. thus, the glycoprotein is the antigen responsible for these immunologic responses. | 1980 | 6250990 |
| [antigenic capacity of junin virus inactivated by photodynamic oxidation]. | | 1980 | 6251337 |
| [infection of new world primates by junin virus. ii callithrix jacchus]. | | 1980 | 6253762 |
| [infection of new world primates by junin virus. ii callithrix jacchus]. | | 1980 | 6253762 |
| [effect of cyclophosphamide and antithymocyte serum on the resistance of the adult rat to junin virus]. | | 1980 | 6253763 |
| [preliminary study of an atenuated variant of junin virus derived from the xj prototype strain]. | | 1980 | 6253764 |
| [various aspects of experimental infection of the guinea pig with an attenuated variant of junin virus]. | | 1980 | 6259493 |
| [various aspects of experimental infection of the guinea pig with an attenuated variant of junin virus]. | | 1980 | 6259493 |
| [genesis of interferent particles during the multiplication of junin virus in vivo]. | | 1980 | 6259494 |
| junin virus infection of guinea pigs: immunohistochemical and ultrastructural studies of hemopoietic tissue. | an association between viral antigens, cytopathic effect (cpe) and viral titers in blood and lymphoid tissues suggests a direct cpe of junin virus on the lymphopoietic organs of guinea pigs infected with 10(3) 50% lethal doses of the xj prototype strain. after seven days of infection, all lymphoreticular organs had infectivity titers higher than those for blood. virus was recovered from bone marrow and lymph nodes at day 5 after infection; peak titers were obtained from bone marrow, spleen, and ... | 1981 | 6260868 |
| junin virus infection of guinea pigs: immunohistochemical and ultrastructural studies of hemopoietic tissue. | an association between viral antigens, cytopathic effect (cpe) and viral titers in blood and lymphoid tissues suggests a direct cpe of junin virus on the lymphopoietic organs of guinea pigs infected with 10(3) 50% lethal doses of the xj prototype strain. after seven days of infection, all lymphoreticular organs had infectivity titers higher than those for blood. virus was recovered from bone marrow and lymph nodes at day 5 after infection; peak titers were obtained from bone marrow, spleen, and ... | 1981 | 6260868 |
| serological survey to detect subclinical junín virus infection in laboratory personnel. | serological survey for detecting subclinical infections with junín virus, the etiological agent of argentine hemorrhage fever, was carried out in a group of 107 individuals working in laboratories where this virus was handled. the group was divided into high risk and low risk personnel according to the degree of exposure to the virus. neutralizing tests were performed in vero cell cultures to detect circulating antibodies. results were evaluated comparatively with those obtained in a previous su ... | 1980 | 6262457 |
| description of a bhk/21 cell line persistently infected with junin virus: its use in diagnostic procedures. | a bhk/21 cell line persistently infected by an arenavirus is described. during four consecutive passages, 30-45% of the cells showed granular cytoplasmic antigen by indirect immunofluorescence, employing both argentine hemorrhagic fever convalescent sera and sera from animals immunized with junin virus. virus isolated from the cells killed suckling mice but not adult mice and protected guinea pigs against further challenge with the virulent prototype strain of junin virus. neutralization tests s ... | 1980 | 6263820 |