| [changes in the age structure of the labor force by occupation in quebec, 1981-1986]. | the author examines trends in the age structure and size of the labor force in quebec, canada, for the period 1981-1986. "using simulations, the author shows that the occupational structure of workers as a whole is less influenced by the decrease in the number of young workers...than by occupational changes observed among young workers." (summary in eng and spa) | 1990 | 12283933 |
| [the economically active population in an era of low fertility]. | the links between demographic trends and the evolution of the labor force are analyzed in the context of quebec, canada. four aspects are considered: the presence of children, the numerical changes between generations, migration, and demographic aging. the author notes that consequences of current trends include increased participation in the labor force by women and young people. | 1991 | 12284395 |
| [declaration: women, populations and environment]. | this statement from the quebec committee on women and development argues that rapid population growth, and thus the high fertility of poor women, is not the basic development problem in the third world. the view that overpopulation is the cause of environmental degradation implies that the solution must be found in reducing the number of poor people rather than in profoundly altering the dominant economic model. the persisting world environmental crisis has encouraged a malthusian conception o ... | 1993 | 12291193 |
| [fertility behavior in quebec, family allowances, and taxes: results and simulations with a discrete choice model for the years 1975-1987]. | "we suppose that women (couples), who are less than 40 years old, are faced with three types of sequential decisions: the fertility decision, the decision relative to the number of children to have and the decision concerning labour force participation.... we use a nested polychotomous discrete choice model to estimate the responsiveness of the behaviour of 'married' women in quebec to variations in the expected flow of revenue resulting from changes in the parameters of the personal income tax ... | 1994 | 12291903 |
| [the availability of university graduates in the quebec labor force]. | a decline in the number of university graduates in the quebec labor force in comparison with the labor force in the rest of canada is noted. reasons for this trend are sought both in the decline in the number of those graduating and in the migration of graduates out of quebec. the implications of the further reductions in support for university budgets under consideration by the quebec government are discussed. | 1981 | 12312217 |
| [can one reconcile a pro-natalist policy with feminism?]. | a review of the current debate in quebec concerning the need for a pro-natalist policy is first presented. the author then summarizes the experiences of eastern european countries and france with regard to the effectiveness of pro-natalist policies. the impact of alternative pro-natalist measures in quebec is considered, with particular reference to the role women play in the labor force. finally, the author examines the role of maternity from a feminist perspective and sketches the elements ... | 1981 | 12312379 |
| [specificity of female unemployment]. | the author develops the argument that "female unemployment should not be tackled in the same way as male unemployment because women's situation within the family and in the labor market is different. the author proposes a new vision of female unemployment, taking into account the dialectical situation experienced by women because of their double role, in the sphere of reproduction as well as in the sphere of economic production." the primary geographic focus is on the situation in quebec. (summ ... | 1985 | 12314319 |
| [the evolution of female single parent families in various regions of quebec, 1971-1981]. | developments concerning single-parent, female-headed households in quebec are analyzed. the authors note that in contrast to past experience, "the new single parent family is in most cases the result of a voluntary disruption of the household, or of a birth outside marriage; its head is mostly--and increasingly--the mother; and it concerns an increasingly younger population, among parents as well as children." differences among metropolitan regions are analyzed with regard to labor force partic ... | 1985 | 12314320 |
| [class, sex, and socio-professional trajectory: the case of haitian immigration to quebec]. | "various studies have shown the role of haitian immigration in satisfying the need for manpower in quebec. very few, however, analyse the process which leads immigrants to this role. this paper shows that sex and class in the country of origin strongly determine the socio-professional trajectory of haitian immigrants in quebec. these two factors define indeed a specific process of skill acquisition, and, therefore, a more or less strong bargaining power on the labor market." (summary in eng a ... | 1985 | 12314324 |
| [the capitalist development of regions and labor force mobility in quebec, from 1966 to 1976]. | "in this paper the author presents a study of the spatial mobility of the quebec population between 1966 and 1976, in the light of regional capitalist development. based on an empirical operationalization of the concepts of mobility and development, the author demonstrates that quebec presents a very irregular distribution of its poles of development over its territory, and that the mobility of the work force is in the image of this distribution. a few regions within the montreal metropolitan ... | 1987 | 12315208 |
| [nuptiality and professional groups in quebec during the french regime]. | "the demographic regime that historically characterizes any given society constitutes a complex whole in which several elements interact. in relation to marriages, we have been able to demonstrate that, for the city of quebec during the french regime, the age of first marriages reflects a specific division of tasks according to sex within the family. at the same time, it is a reflection of the differences that exist in the possibilities for getting established and the requirements of rank amon ... | 1987 | 12315210 |
| act amending the charter of human rights and freedoms with respect to the commission and establishing a human rights tribunal, 22 june 1989. | among other things, this quebec, canada act enlarges the duties of the human rights commission and establishes a human rights tribunal. the tribunal has the authority to hear cases dealing with employment, housing, public goods and services, and equal access programs referred to it by the commission when parties refuse to negotiate; when urgent measures need to be undertaken because of a threat to the life, health, or safety of a person; and when retaliatory measures are taken against a person ... | 1989 | 12344089 |
| tremblay v. daigle, 8 august 1989. | the putative father of an 18-week-old fetus sought an injunction to prevent the mother from having an abortion. the canadian supreme court reversed a lower court ruling granting the injunction (see dominion law reports, series 4, vol. 59, p. 609). it held that a fetus is not a "human being" under the quebec charter of human rights and freedoms or the quebec civil code and is not a "person" under anglo-canadian law. it also concluded that a father's interest in a fetus does not give him the rig ... | 1989 | 12344357 |
| [decennial censuses of the labor force using a population register. presentation of a methodology]. | the authors describe the way in which the balsac computerized population register was used to reconstruct a decennial census of the active male population in the region of saguenay, quebec, between 1851 and 1961. this type of analysis was not feasible using canadian government census data because of methodological changes from one census to the next and because the data were often aggregated at the provincial level. the balsac register contains all records of baptism, marriage, and burial from ... | 1997 | 12348493 |
| the k-cl cotransporter kcc3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. | peripheral neuropathy associated with agenesis of the corpus callosum (accpn) is a severe sensorimotor neuropathy associated with mental retardation, dysmorphic features and complete or partial agenesis of the corpus callosum. accpn is transmitted in an autosomal recessive fashion and is found at a high frequency in the province of quebec, canada. accpn has been previously mapped to chromosome 15q. the gene slc12a6 (solute carrier family 12, member 6), which encodes the k+-cl- transporter kcc3 a ... | 2002 | 12368912 |
| a missense mutation (r565w) in cirhin (flj14728) in north american indian childhood cirrhosis. | north american indian childhood cirrhosis (cirh1a, or naic), a severe autosomal recessive intrahepatic cholestasis described in ojibway-cree children from northwestern quebec, is one of several familial cholestases with unknown molecular etiology. it typically presents with transient neonatal jaundice, in a child who is otherwise healthy, and progresses to biliary cirrhosis and portal hypertension. clinical and physiological investigations have not revealed the underlying cause of the disease. c ... | 2002 | 12417987 |
| a longitudinal study of pain sensitivity and blood pressure in adolescent boys: results from a 5-year follow-up. | a growing literature has observed a significant reduction in pain sensitivity among hypertensive animals and humans. it is uncertain whether a reduced sensitivity to pain can be observed in nonnotensive individuals who go on to develop high blood pressure. blood pressure (bp) was reassessed in one hundred fifteen 19-year-old boys initially tested at age 14, when they were also presented with a pain stimulus (mechanical finger pressure). hierarchical regression analyses indicated that information ... | 2002 | 12433012 |
| [a research partnership in a multiethnic setting]. | the objective of this paper is to describe a research partnership endeavour with five community organizations focusing their work on facilitating the integration of immigrant populations in the montreal area. survey data were collected in order to obtain a sociodemographic picture of recent immigrant women (n = 254), their knowledge of info-santé clsc services and their use of those services. focus group discussions were also carried out to explore the needs of these women with regards to the va ... | 2002 | 12448871 |
| hiv risk profile and prostitution among female street youths. | the objective of this study was to compare human immunodeficiency virus (hiv) risk factors among female street youths involved in prostitution and those with no history of prostitution. youths aged 14 to 25 years were recruited into the montreal street youth cohort. semiannually, youths completed an interviewer-administered questionnaire. statistical analyses comparing characteristics and hiv risk factors for girls involved in prostitution and those never involved were carried out using parametr ... | 2002 | 12468672 |
| support for the presence of bipolar disorder susceptibility loci on chromosome 5: heterogeneity in a homogeneous population in quebec. | a very large pedigree derived from the saguenay-lac-st-jean region of quebec contains a branch where a distal chromosome 5q haplotype seems to cosegregate with bipolar affective disorder. the authors used a diagnosis model where bipolar types i and ii and schizoaffective disorder bipolar type were considered as affected, while single or recurrent episode major depression was classified as unknown and all the others diagnoses as unaffected. model-free two-point lod score values of 3.41 and 2.21 w ... | 2002 | 12502013 |
| comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. | polychlorinated biphenyls (pcbs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. extensive evidence from animal studies shows that pcbs are neurotoxins, even at low doses. interpretation of human data regarding low-level, early-life pcb exposure and subsequent neurodevelopment is problematic because levels of exposure were not similarly quantified across studies. we expres ... | 2003 | 12515680 |
| use of nsaids, cox-2 inhibitors, and acetaminophen and associated coprescriptions of gastroprotective agents in an elderly population. | to identify determinants of cyclooxygenase 2 (cox-2) inhibitor versus nonsteroidal antiinflammatory drug (nsaids) or acetaminophen prescription in seniors; and to compare gastroprotective agent coprescriptions. | 2002 | 12522832 |
| investigation of the presence of amino and nitro polycyclic aromatic hydrocarbons in a söderberg primary aluminum smelter. | an excessive risk of bladder cancer among söderberg primary aluminum smelter potroom workers has been reported by several authors, and to date, a causal agent has not been identified. certain nitro and amino polycyclic aromatic hydrocarbons (pahs) are either known or suspected human bladder carcinogens, and their presence in this work environment would be cause for concern. in fact, one of these, 2-aminonaphthalene, has been found in both the air and the coal tar pitch used to fabricate process ... | 2002 | 12570080 |
| obtaining consent for research studies on incompetent subjects: the quebec experience. | | 2003 | 12579419 |
| ush1c: a rare cause of ush1 in a non-acadian population and a founder effect of the acadian allele. | usher syndrome (ush) is characterized by the associated findings of hearing loss and retinitis pigmentosa (rp), leading to progressive loss of vision. three forms of ush can be distinguished clinically. in the most severe form, ush1, profound congenital deafness is associated with vestibular dysfunction and rp. to determine the frequency of ush1c mutations as a cause for ush1, 128 probands with usher syndrome type 1 including seven from acadian and 121 from non-acadian populations were systemati ... | 2003 | 12630964 |
| genetic heterogeneity in a very large bipolar affective disorder pedigree from quebec. | we previously reported a genome-wide scan for bipolar affective disorder based on a multigenerational family sampled from a relatively homogeneous population derived from founding families that migrated to an isolated area of quebec from the early 1830s onwards. for the genome scan, the pedigree was split into five branches to facilitate calculation and a second family was added to more specifically analyze chromosome 12 results. in the present study, we reanalyzed the undivided pedigree after g ... | 2003 | 12707941 |
| risks associated with transfusion of cellular blood components in canada. | we provide a comprehensive review of risks associated with allogeneic red blood cell and platelet transfusions in canada. the review focuses on clinically symptomatic noninfectious transfusion risks (acute and delayed hemolytic, febrile nonhemolytic [fnhtr], allergic, volume overload, transfusion-related acute lung injury, graft-versus-host disease, and posttransfusion purpura) and the risk of clinically significant disease from transfusion-transmitted infections. data sources include informatio ... | 2003 | 12733105 |
| association between the length of the vas deferens excised during vasectomy and the risk of postvasectomy recanalization. | to evaluate the association between the length of the vas deferens excised during vasectomy and the risk of recanalization. | 2003 | 12749445 |
| antimicrobial resistance of campylobacter jejuni subsp. jejuni strains isolated from humans in 1998 to 2001 in montréal, canada. | the rates of resistance of 51 to 72 human strains of campylobacter jejuni subsp. jejuni isolated annually from 1998 to 2001 in montréal, québec, canada, varied from 1 to 12% for erythromycin, 43 to 68% for tetracycline, and 10 to 47% for ciprofloxacin. in the last years of the study, there was a significant increase in the rate of resistance to ciprofloxacin (p = 0.00003) but not in the rate of resistance to erythromycin (p = 0.056) or tetracycline (p = 0.095) compared to the rate obtained in th ... | 2003 | 12760892 |
| hereditary motor and sensory neuropathy with agenesis of the corpus callosum. | hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (omim 218000) is an autosomal recessive disease of early onset characterized by a delay in developmental milestones, a severe sensory-motor polyneuropathy with areflexia, a variable degree of agenesis of the corpus callosum, amyotrophy, hypotonia, and cognitive impairment. although this disorder has rarely been reported worldwide, it has a high prevalence in the saguenay-lac-st-jean region of the province of ... | 2003 | 12838516 |
| assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the inuit cohort study. | polychlorinated biphenyls (pcbs) are food-chain contaminants that have been shown to induce adverse developmental effects in humans. in the course of an epidemiologic study established to investigate neurodevelopmental deficits induced by environmental pcb exposure in the inuit population of northern québec (nunavik, canada), we compared three biomarkers of prenatal exposure and models to predict pcb plasma concentration at 6 months postpartum. concentrations of 14 pcb congeners were measured by ... | 2003 | 12842782 |
| genome-wide linkage scan for physical activity levels in the quebec family study. | it is commonly recognized that there is familial aggregation for physical activity level. however, the genes and sequence variants responsible for the familial clustering have not been investigated. we performed a genome-wide linkage scan based on 432 markers typed in 767 subjects from 207 families of the quebec family study with the aim of identifying loci affecting physical activity levels. four physical activity level phenotypes were used. | 2003 | 12900690 |
| monitoring of umbilical cord blood lead levels and sources assessment among the inuit. | analyses completed on samples collected between 1993 and 1996 showed that about 7% of 475 inuit newborns from northern quebec (canada) had a cord blood lead concentration equal to or greater than 0.48 micromol/l, an intervention level adopted by many governmental agencies. a comparison between the cord blood lead isotope ratios of inuit and southern quebec newborns showed that lead sources for these populations were different. our investigation suggests that lead shots used for game hunting were ... | 2003 | 12937194 |
| effects of low concentrations of organochlorine compounds in women on calcium transfer in human placental syncytiotrophoblast. | for most canadians, food represents one of the major sources of environmental contaminants. among them, organochlorine compounds (ocs) are known to affect calcium (ca2+) homeostasis. they are neurotoxic by perturbation of ca2+ channels and pumps, and they interfere with protein kinase c (pkc) and ca2+ binding protein (cabp). ca2+ is an essential element to adequate fetal growth and development. the aim of the present study is to determine the relation between low environmental maternal exposure ... | 2003 | 12970576 |
| q fever in canada. | a canada-wide survey of q fever was begun in 1958 in co-operation with public health and veterinary laboratories to determine the presence and prevalence of the disease so that medical practitioners might be alerted to the potential dangers existing. serologic evidence obtained indicated that the q fever rickettsia now exists in cattle in all provinces of canada except new brunswick, nova scotia, and prince edward island. isolations of the rickettsia were obtained from bovine milk samples from o ... | 1964 | 14175873 |
| [thalassemia in quebec]. | | 1964 | 14183889 |
| blood groups of the naskapi and montagnais indians of schefferville, quebec. | | 1964 | 14210757 |
| evolution of surface and nonstructural-1 genes of influenza b viruses isolated in the province of québec, canada, during the 1998-2001 period. | after 2 minor winter seasons, influenza b viruses were predominantly isolated in the province of quebec, canada, during the 2000-2001 season representing 74% of laboratory-confirmed influenza viruses. we performed an antigenic study of the hemagglutinin (ha) protein and a molecular characterization of the ha1 region, nonstructural-1 (ns1) and neuraminidase (na)/nb genes of 20 influenza b strains isolated in the province of quebec during the 1998-2001 period. our isolates were compared to recent ... | 2003 | 14501190 |
| management of return-to-work programs for workers with musculoskeletal disorders: a qualitative study in three canadian provinces. | in this qualitative research project, researchers in three canadian provinces explored the perceptions of many different actors involved in return-to-work (rtw) programs for injured workers, studying their views on successful rtw strategies and barriers to/facilitators of the rtw process, then analyzing the underlying dynamics driving their different experiences. each research team recruited actors in a variety of different workplaces and key informants in the rtw system, and used a combination ... | 2003 | 14512241 |
| knowing, mapping and understanding st. lawrence biodiversity, with special emphasis on bird assemblages. | environment canada and the québec department of the environment, partners in the st lawrence vision 2000 action plan, set out to prepare a compendium of knowledge of the flora and fauna of the st lawrence and to identify potential conservation sites. the resulting portrait is an internet site that presents the current knowledge base of the river's ecological and biological diversity (http://lavoieverte.qc.ec.gc.ca/faune/biodiv/index.html). the portrait provides information on over 5,000 species ... | 2003 | 14570415 |
| how does fluoride concentration in the tooth affect apatite crystal size? | despite fluoride's (f) well-documented ability to prevent caries, the effects of f concentrations on enamel and dentin apatite crystals are unknown. the present study examined the hypothesis that tooth f concentration and tooth crystallite size correlate. one hundred human unerupted third molars were studied-53 from fortaleza-brazil (f water 0.7 ppm), 23 from toronto (1.0 ppm), and 24 from montreal (0.2 ppm). f concentration was analyzed by neutron activation analysis and apatite crystal size by ... | 2003 | 14578504 |
| seroprevalence of antibodies against human herpesvirus 8 in a population of renal transplant recipients at hôtel-dieu de québec hospital. | we conducted a seroepidemiologic study to determine the prevalence of anti-human herpesvirus 8 antibodies in a renal transplant population at hôtel-dieu de québec hospital. testing for immunoglobulin g antibodies against lytic and latent antigens was performed on serum samples from 150 renal transplant patients. human immunodeficiency virus-positive patients with confirmed kaposi's sarcoma were used as positive controls. none of the renal transplant patients tested positive. | 2003 | 14605164 |
| trihalomethanes in drinking water of greater québec region (canada): occurrence, variations and modelling. | the levels of trihalomethanes (thms)--the main species of by-product from water chlorination--were monitored in the distribution systems of the five major drinking water utilities of the greater area of québec city in order to investigate and model their occurrence on a spatial and seasonal basis. data for thms and other water quality and operational parameters associated with their formation were generated through a 16 month sampling program involving several sites representing variable water r ... | 2003 | 14609275 |
| influenza-like illness during pregnancy: results from a study in the eastern townships, province of quebec. | (1) to assess the frequency of influenza and influenza-like illness (ili) during pregnancy; (2) to explore the associated risk of adverse maternal and fetal outcomes. | 2003 | 14663536 |
| research on subjects incapable of giving informed consent: the situation in dutch intensive care departments. | | 2003 | 14669785 |
| genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the quebec family study. | a genome-wide linkage study was performed to identify chromosomal regions harboring genes influencing lipid and lipoprotein levels. linkage analyses were conducted for four quantitative lipoprotein/lipid traits, i.e., total cholesterol, triglyceride, hdl-cholesterol (hdl-c), and ldl-c concentrations, in 930 subjects enrolled in the québec family study. a maximum of 534 pairs of siblings from 292 nuclear families were available. linkage was tested using both allele-sharing and variance-component ... | 2004 | 14679165 |
| academic health leadership: looking to the future. proceedings of a workshop held at the canadian institute of academic medicine meeting québec, que., canada, apr. 25 and 26, 2003. | the academic health sector will face major changes in governance, health care delivery, educational requirements and research programs over the next decade. increased emphasis on disease prevention and health outcomes, the need for evidence to support both clinical and policy decisions, educational changes both in content and delivery, and the importance of working in teams will challenge the academic health care community. large research teams may require new ways of training and nurturing youn ... | 2003 | 14690305 |
| arsacs goes global. | | 2004 | 14718687 |
| effects of defendant age on severity of punishment for different crimes. | after reading a murder or theft vignette in which the perpetrator was a 20-, 40-, or 60-year-old man, 95 undergraduates gave sentence and parole recommendations. punishment was harsher for the murder than for the theft. for murder, participants treated the 20- and 60-year-old men less harshly than the 40-year-old man, which confirms previous archival findings. however, this inverted u-shaped function occurred for murder only. the authors discussed the results in the context of the just-desert an ... | 2004 | 14760966 |
| powered tilt/recline systems: why and how are they used? | prolonged static sitting can lead to discomfort, pain, pressure sores, spinal curvatures, and loss of functional independence. in order to counteract these harmful effects, adjustable tilt and/or recline systems are often prescribed. considering the current context of assistive technology service delivery and budget cuts, it is essential to have a better knowledge of the use of these technical aids and user's satisfaction with them. the purpose of this study was to characterize the use of powere ... | 2003 | 14760982 |
| characterization of campylobacter isolates recovered from clinically healthy pigs and from sporadic cases of campylobacteriosis in humans. | campylobacter spp. were recovered from 660 (77.6%) of 850 swine cecal contents at the abattoir and from 24 (8.6%) of 278 specimens from sporadic cases of human diarrhea during the same period in the same geographical area. campylobacter coli represented 95.7% of campylobacter isolates recovered from pigs and 8.3% of those isolated from humans. genetic profiles were determined by pulsed-field gel electrophoresis (pfge) using kpni enzyme to characterize the isolates in combination with phenotypic ... | 2004 | 14968951 |
| animal ethical evaluation: an observational study of canadian iacucs. | three canadian institutional animal care and use committees were observed over a 1-year period to investigate animal ethical evaluation. while each protocol was evaluated, the observer collected information about the final decision, the type of protocol (research vs. teaching), and the category of invasiveness. the observer also wrote down verbatim all verbal interventions, which were coded according to the following categories: scientific, technical, politics, human analog, reduction, refinemen ... | 2003 | 15000096 |
| human exposure to respirable manganese in outdoor and indoor air in urban and rural areas. | methylcyclopentadienyl manganese tricarbonyl (mmt), is an additive in gasoline, and its combustion leads to the emission of mn particles, which increase atmospheric metal concentrations. the objective of this study was to determine the level of outdoor and indoor respirable mn (mnr) in montreal, canada, where mmt has been used since 1976. ten women were involved in this study: five living in an urban area, near an expressway with high traffic density, and five residing in a rural area characteri ... | 2004 | 15000130 |
| a magical dream: a pilot project in animal-assisted therapy in pediatric oncology. | for children with cancer, being hospitalized represents a great source of stress. hospitalized children are not only deprived of their familiar and comforting world, but they must also face various and often painful treatments. they must quickly adapt to new people and to an environment that is very different from that of their homes. they have greater safety needs. thus, it is important to offer these children concrete ways to better adapt to the stresses of hospitalization. animal-assisted the ... | 2004 | 15040146 |
| an overview of the types of physicians treating acute cardiac conditions in canada. | as the issue of physician supply and distribution increases in intensity in canada, the scope of practice of different types of physicians becomes increasingly important. | 2004 | 15054505 |
| identification of a novel gene (hsn2) causing hereditary sensory and autonomic neuropathy type ii through the study of canadian genetic isolates. | hereditary sensory and autonomic neuropathy (hsan) type ii is an autosomal recessive disorder characterized by impairment of pain, temperature, and touch sensation owing to reduction or absence of peripheral sensory neurons. we identified two large pedigrees segregating the disorder in an isolated population living in newfoundland and performed a 5-cm genome scan. linkage analysis identified a locus mapping to 12p13.33 with a maximum lod score of 8.4. haplotype sharing defined a candidate interv ... | 2004 | 15060842 |
| genetics. two new asthma genes uncovered. | | 2004 | 15073340 |
| characterization of a common susceptibility locus for asthma-related traits. | susceptibility to asthma depends on variation at an unknown number of genetic loci. to identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. one of these coded for an orphan g protein-coupled receptor named gpra (g protein-coupled receptor for asthma susceptibility), which showed distinct distribution of protein isoforms between bronchial biopsies from healthy and ... | 2004 | 15073379 |
| tourette syndrome and dopaminergic genes: a family-based association study in the french canadian founder population. | tourette syndrome (ts) is a genetically complex disorder for which no causative genes have been unequivocally identified. nevertheless, a number of molecular genetic studies have investigated several candidate genes, particularly those implicated in dopamine modulation. the results of these studies were inconclusive, which may be due, at least in part, to the variable ethnicity of the patients included in different studies and the chosen research design. in this study, we used a family-based ass ... | 2004 | 15094788 |
| association between 7q31 markers and tourette syndrome. | tourette syndrome (ts) is a complex neuropychiatric disorder with a strong genetic basis. although no specific susceptibility genes have been identified for ts, cytogenetic studies in selected cases suggest the existence of a predisposing gene located in the 7q31 chromosomal region. in order to test the hypothesis of a possible relationship between this region and ts at the population level, we undertook a family based association study in a sample of french canadian patients from quebec. for th ... | 2004 | 15103711 |
| the role of the lrpprc (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of cox (cytochrome c oxidase) i and cox iii mrna. | leigh syndrome french canadian (lsfc) is a variant of cytochrome oxidase deficiency found in québec and caused by mutations in the lrpprc (leucine-rich pentatricopeptide repeat cassette) gene. northern blots showed that the lrpprc mrna levels seen in skeletal muscle>heart>placenta>kidney>liver>lung=brain were proportionally almost opposite in strength to the severity of the enzymic cytochrome oxidase defect. the levels of cox (cytochrome c oxidase) i and cox iii mrna visible on northern blots we ... | 2004 | 15139850 |
| hpa-5b (bra) neonatal alloimmune thrombocytopenia in quebec: incidence and clinical outcome in 31 cases. | clinical detection of neonatal allo-immune thrombocytopenia (naitp) is often less than the incidence predicted in prospective studies. the aims of this study were to calculate the observed and expected incidence of naitp in quebec, canada, and to evaluate the clinical outcome of infants with anti-hpa-5b naitp. | 2004 | 15157249 |
| nonylphenolic compounds in drinking and surface waters downstream of treated textile and pulp and paper effluents: a survey and preliminary assessment of their potential effects on public health and aquatic life. | eleven drinking water treatment plants, located downstream of textile plants or pulp and paper mills, have been sampled monthly during a year for the analysis of 17 nonylphenol ethoxylates (np1-17eo) and two nonylphenoxycarboxylic acids (np1-2ec). at all but one plant, results in the drinking water, for the sum of these 19 substances, range between below detection levels and 6.7 microg/l. annual means are between 0.02 and 2.8 microg/l. at the other plant, the yearly average concentration is 10.4 ... | 2004 | 15172597 |
| assessment of surveillance of human west nile virus infection in quebec, 2003. | | 2004 | 15188913 |
| low environmental contamination by lead in pregnant women: effect on calcium transfer in human placental syncytiotrophoblasts. | there is an extensive literature on the neurotoxic effects of lead (pb) on the developing fetus; however, little is known about the mechanisms of action at low levels. heavy metals are known to affect calcium (ca2+) homeostasis through perturbation of ca2+ channels and pumps and interference with protein kinase c (pkc) and ca2+ binding protein (cabp). during pregnancy, placental ca2+ exchange is one of the most important mechanisms for fetal survival. this ion is an essential element for healthy ... | 2004 | 15205024 |
| québec: an outbreak of hiv/aids-related stigma and discrimination. | in the space of a few weeks in january 2004, actions by three different institutions in québec combined to threaten the human rights of people living with hiv/aids, raise the spectre of mandatory hiv testing, and create unnecessary public fears about the spread of hiv infection. in response to what they called "the worst weeks in recent history for people living with hiv/aids in québec," the canadian hiv/aids legal network and cocq-sida (the québec coalition of community-based organizations figh ... | 2004 | 15216808 |
| a genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern quebec affected by psychoses. | antipsychotics can induce in schizophrenic (sz) and bipolar disorder (bp) patients serious body weight changes that increase risk for noncompliance to medication, and risk for cardiovascular diseases and diabetes. a genetic origin for this susceptibility to weight changes has been hypothesized because only a proportion of treated patients are affected, the degree of affection differing also in rates and magnitudes. in a first genome scan on obesity under antipsychotics in sz and bp, we analyzed ... | 2004 | 15224101 |
| stress during pregnancy affects general intellectual and language functioning in human toddlers. | prenatal maternal stress has been shown to impair functioning in nonhuman primate offspring. little is known about the effects of prenatal stress on intellectual and language development in humans because it is difficult to identify sufficiently large samples of pregnant women who have been exposed to an independent stressor. we took advantage of a natural disaster (january 1998 ice storm in québec, canada) to determine the effect of the objective severity of pregnant women's stress exposure on ... | 2004 | 15240860 |
| [intervention to promote recognition of the rights of families of an elderly relative with dementia living in a long-term care facility]. | the rights of families of an institutionalized elderly relative with dementia have yet to be recognized. the results of our pilot study based on a participatory approach show, among other things, that family caregivers, women for the most part, have little input in the decisions regarding their relative's care and are uneasy to express their opinions to health care staff. as part of the pilot study, caregivers developed a group intervention program entitled "taking care of myself" geared, among ... | 2004 | 15253070 |
| putative common origin of two mlh1 mutations in italian-quebec hereditary non-polyposis colorectal cancer families. | hereditary non-polyposis colorectal cancer (hnpcc) is one of the most common inherited cancer syndromes, accounting for 3-5% of all cases of colorectal cancer. in most hnpcc families, the disease is caused by a germline mutation in mlh1 or msh2. in some populations, founder mutations appear to explain a substantial fraction of hnpcc. we report here the identification and preliminary characterization of two putative mlh1 founder mutations. the mutation mlh1c.1831delat was shown to segregate in tw ... | 2004 | 15253764 |
| a preliminary investigation on the infectivity of trichinella larvae in traditional preparations of walrus meat. | this study evaluated the infectivity of trichinella nativa in freshly frozen walrus meat and traditionally aged walrus meat (igunaq) associated with two human outbreaks of trichinellosis in the canadian arctic. trichinella larvae recovered from walrus meat stored at -20 degrees c for up to 20 months remained infective for guinea pigs inoculated with 135 or 716 larval doses. however, none of the 4-5 and 10-month-old igunaq preparations contained infective t. nativa larvae as measured by bioassays ... | 2004 | 15278445 |
| the conduct of canadian researchers and institutional review boards regarding substituted consent for research. | | 2004 | 15281211 |
| association of vitamin d receptor genetic variants with susceptibility to asthma and atopy. | genome scans for asthma have identified suggestive or significant linkages on 17 different chromosomes, including chromosome 12, region q13-23, housing the vitamin d receptor (vdr) gene. through interaction with vdr, 1,25-dihydroxyvitamin d3 mediates numerous biological activities, such as regulation of helper t-cell development and subsequent cytokine secretion profiles. variants of the vdr have been found to be associated with immune-mediated diseases that are characterized by an imbalance in ... | 2004 | 15282199 |
| mortality in a cohort of street youth in montreal. | many studies have shown a high prevalence of sexually transmitted diseases, human immunodeficiency virus (hiv) infection, viral hepatitis, drug dependence, and mental health problems among street youth. however, data on mortality among these youth are sparse. | 2004 | 15292082 |
| practice makes perfect: preparing graduate nurses for professional licensure. | in the fall of 2000, the licensing examination for nursing taken by candidates in the province of quebec was altered to include an oral practical component. this article describes how a group of nurse clinician educators, despite severe time and human resources constraints, developed a unique and interactive program to assist graduate unlicensed nurses to successfully prepare for this new examination process. | 2004 | 15295262 |
| rates of influenza vaccination in older adults and factors associated with vaccine use: a secondary analysis of the canadian study of health and aging. | influenza vaccination has been shown to reduce morbidity and mortality in the older adult population. in canada, vaccination rates remain suboptimal. we identified factors predictive of influenza vaccination, in order to determine which segments of the older adult population might be targeted to increase coverage in influenza vaccination programs. | 2004 | 15306030 |
| effect of 4-aminopyridine on gait in ambulatory spinal cord injuries: a double-blind, placebo-controlled, crossover trial. | animal and human research have shown that the drug 4-aminopyridine (4-ap) may improve gait in spinal cord lesions by enhancing nerve transmission to affected muscles. | 2004 | 15356676 |
| [nursing practice in the context of geographic isolation: implications for training]. | a survey on the characteristics of the unique working context of nursing practice in remote areas of french polynesia and semi-remote areas of northern quebec demonstrates the importance of a specific training to best prepare the professionals who find themselves in this type of setting. twenty professionals were interviewed: six nurses practicing in isolated stations in french polynesia (tuamotu archipelago, marquesas islands and austral islands), six nurses practicing in semi-remote areas with ... | 2004 | 15360177 |
| skeletal age, dental age, and the maturation of knm-wt 15000. | the skeleton of the homo erectus boy from west lake turkana, kenya (knm-wt 15000), is remarkably complete, and this individual has thus provided a case study for several researchers examining homo erectus growth. using data from a longitudinal study of montreal french-canadian children, it is shown that while dental and skeletal ages match reasonably well at the level of a sample of children, individuals can display differences between skeletal and dental ages of 2 years or more. furthermore, th ... | 2004 | 15365977 |
| nlgn3/nlgn4 gene mutations are not responsible for autism in the quebec population. | jamain [2003: nat genet 34:27-29] recently reported mutations in two neuroligin genes in sib-pairs affected with autism. in order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. we found no mutations in these x-linked genes. these results indicate that mutations in nlgn3 and nlgn4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populatio ... | 2005 | 15389766 |
| patients' perspectives on high-tech home care: a qualitative inquiry into the user-friendliness of four technologies. | the delivery of technology-enhanced home care is growing in most industrialized countries. the objective of our study was to document, from the patient's perspective, how the level of user-friendliness of medical technology influences its integration into the private and social lives of patients. understanding what makes a technology user-friendly should help improve the design of home care services. | 2004 | 15462682 |
| ministerial action plan on research ethics and scientific integrity. | | 1998 | 15468465 |
| [influenza prevention, surveillance, and control in long term care facilities]. | describe the implementation of various activities suggested in the guide entitled prevention, surveillance et contrôle de l'influenza en milieu d'hébergement et de soins de longue durée (chsld) au quebec, distributed in 2000 to montréal-area chsld. | 2004 | 15490930 |
| a genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12. | our previous results pointed to a putative gene for susceptibility to bipolar affective disorder located on the chromosomal region 12q23-q24 that segregated in the saguenay-lac-st-jean population of quebec. we report here results from a second genome-wide scan based on the analysis of 380 polymorphic microsatellite markers. for the purpose of this analysis, an additional 18 families were recruited from the saguenay-lac-st-jean region and pooled to our previous sample to improve its statistical p ... | 2005 | 15494705 |
| the quebec hemovigilance system: description and results from the first two years. | following federal and provincial reviews of the blood system, the canadian province of quebec passed a series of legislative and administrative measures to improve blood safety, including the establishment of a hemovigilance system, and made infrastructure and human resource investments to support their implementation. the quebec hemovigilance system was inspired by the french system using similar data elements and case definitions, grading of severity and determination of likelihood of associat ... | 2004 | 15501415 |
| shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in eastern quebec families. | the goal of this study was to identify susceptibility loci shared by schizophrenia (sz) and bipolar disorder (bp), or specific to each. to this end, we performed a dense genome scan in a first sample of 21 multigenerational families of eastern quebec affected by sz, bp or both (n=480 family members). this probably constitutes the first genome scan of sz and bp that used the same ascertainment, statistical and molecular methods for the concurrent study of the two disorders. we genotyped 607 micro ... | 2005 | 15534619 |
| obesity research in canada: literature overview of the last 3 decades. | to identify research published on obesity in canada, to explore the range of areas studied, and to identify gaps and areas that merit future research attention. | 2004 | 15536218 |
| neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity. | obesity is frequently associated with eating disorders, and evidence indicates that both conditions are influenced by genetic factors. however, little is known about the genes influencing eating behaviors. | 2004 | 15585758 |
| [should we vaccinate infants against influenza? yes!]. | | 2004 | 15624639 |
| exclusion of non-synonymous snps and a polyglutamine tract in smrt/n-cor2 as common deleterious mutation for bipolar disorder in the sagnenay-lac-st-jean population. | bipolar disorder (bp) is a psychiatric illness with both genetic and environmental components occurring with a prevalence of slightly more than 1%. our previous linkage and case/control studies have pointed to a susceptibility locus for bp in the 12q24.31 chromosomal region. here, we investigated the possible involvement of the smrt/n-cor2 gene, which encodes for the nuclear receptor co-repressor 2. smrt/n-cor2 was retained as a candidate gene for bp because of its location within our candidate ... | 2005 | 15635693 |
| classic kaposi's sarcoma in the inuit of northern quebec. | classic kaposi's sarcoma (ks) is predominantly a disease of eastern mediterranean and ashkenazi jewish elderly men. nevertheless, the disease has been reported to occur in people from various other ethnic and regional backgrounds. | 2005 | 15692509 |
| mutations in senataxin responsible for quebec cluster of ataxia with neuropathy. | senataxin recently was identified as the mutated gene in ataxia-oculomotor apraxia 2, which is characterized by ataxia, oculomotor apraxia, and increased alpha-fetoprotein levels. in this study, we evaluated 24 ataxic patients from 10 french-canadian families. all cases have a homogeneous phenotype consisting of a progressive ataxia appearing between 2 and 20 (mean age, 14.8) years of age with associated dysarthria, saccadic ocular pursuit, distal amyotrophy, sensory and motor neuropathy, and in ... | 2005 | 15732101 |
| human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated c-peptide in the québec family study. | obesity and insulin resistance are common features of type 2 diabetes. a new protein called resistin has been shown to be secreted by adipocytes in mice and to influence insulin sensitivity. the goal of the present study was to investigate the associations between one polymorphism (g-420c>g) of the human resistin gene and phenotypes related to adiposity and glucose metabolism. we genotyped 725 (including 42 diabetics) adult subjects participating in the quebec family study (qfs) by a minisequenc ... | 2004 | 15754730 |
| [two public health laws: one in quebec, the other in france. what can us teach putting them in parallel]. | | 2004 | 15768752 |
| seroprevalence of parvovirus b19 infection in daycare educators. | this study was undertaken to provide first-time estimates for the seroprevalence of parvovirus b19 infection among daycare educators in montréal, canada, and to identify factors associated with seropositivity. a cross-sectional design was used. directors and educators from 81 daycare centres (dccs) were surveyed about dcc and personal characteristics respectively, and serum samples from 477 female educators were tested for parvovirus b19 igg antibodies. the seroprevalence of parvovirus b19 was 7 ... | 2005 | 15816155 |
| association of dlg5 r30q variant with inflammatory bowel disease. | crohn's disease (cd) and ulcerative colitis (uc) are chronic inflammatory diseases of the gastrointestinal system known as the inflammatory bowel diseases (ibd). recently, stoll and colleagues reported a novel finding of genetic variation in the dlg5 gene that is associated with ibd (cd and uc combined). we present here a study of the genetic variation described in that report in two well-powered, independent case-control cohorts and one family-based collection, and confirm the proposed associat ... | 2005 | 15841097 |
| pesticides and human health: why public health officials should support a ban on non-essential residential use. | the college of family physicians of ontario recently released a comprehensive report on pesticide exposure and health risk, concluding that various pesticides had adverse health effects. the pesticide industry says that pesticides are "safe" when used as directed because they are studied and approved by governmental agencies. yet many municipalities, including canada's three largest, and the province of quebec have enacted bans on cosmetic use of pesticides, largely in response to health concern ... | 2005 | 15850024 |
| [mcgill model]. | | 2005 | 15861915 |
| [claude fortier: the great history of neuroendocrinology]. | the work of claude fortier is linked to the history of neuroendocrinology. through him and his pioneer work in montreal with hans selye, the << man of stress >>, and at laval university in quebec city in his own laboratory, where all researchers involved in the study of the hypothalamo-hypophysial adrenal axis have been through, it is the whole saga of the search for the neuropeptide crh (corticotropin releasing factor), and the harsh fight for the nobel distinction that can be related. among cl ... | 2005 | 15885209 |
| modifiable risk factors associated with clearance of type-specific cervical human papillomavirus infections in a cohort of university students. | previous findings regarding risk factors for human papillomavirus (hpv) persistence, other than viral determinants, identified from prospective cohort studies have been inconsistent in part because study designs have differed with respect to differing hpv detection methods and varying lengths of follow-up time. therefore, the objectives of this study were to continue the search for epidemiologic risk factors of persistent cervical hpv infections and determine what behaviors differed between thos ... | 2005 | 15894665 |