| tuberculosis as a manifestation of the acquired immunodeficiency syndrome (aids). | tuberculosis has not been well documented as a complication of the acquired immunodeficiency syndrome (aids). we studied 48 cases of mycobacterial diseases among a group of 136 adult patients with aids over a 43-month period. twenty-nine of them had severe and unusual manifestations of disease due to mycobacterium tuberculosis, predominantly extrapulmonary and disseminated. tuberculosis was more common among haitians (4/8) and intravenous drug abusers (24/102) than among homosexuals who did not ... | 1986 | 3723722 |
| central nervous system tuberculosis with the acquired immunodeficiency syndrome and its related complex. | central nervous system tuberculosis occurred in three patients with the acquired immunodeficiency syndrome (aids) and seven patients with aids-related complex who were evaluated for 48 months. nine patients were intravenous drug abusers and one was haitian. five patients had cerebral-ring-enhancing lesions and three had hypodense areas. the clinical spectrum included meningitis in two patients, multiple cerebral abscesses in one, and tuberculomas in four. all mycobacterium tuberculosis isolates ... | 1986 | 3729203 |
| movement disorders in bacterial meningitis. | movement disorders developed in five children, ages 6 to 21 months, during the course of bacterial meningitis caused by hemophilus influenzae (one), streptococcus pneumoniae (one), neisseria meningitidis (one), or mycobacterium tuberculosis (two). athetosis, choreoathetosis, and hemiballismus occurred, ranging in duration from hours to months. cranial computed tomography, performed in four cases, showed no lesion of the basal ganglia. the movements were of such abrupt onset and severity that in ... | 1986 | 3734962 |
| tuberculosis in non-haitian patients with acquired immunodeficiency syndrome. | from jan 1, 1981 to oct 31, 1984, 24 of 280 (8.6 percent) patients with acquired immunodeficiency syndrome (aids) had tuberculosis. no patient with both aids and tuberculosis was haitian. in 15 patients, tuberculosis was diagnosed prior to or concomitant with the diagnosis of aids. twelve patients (50 percent) had mycobacterium tuberculosis grown from at least one extrapulmonary site. although the clinical presentation was variable, no patient had cavitary and only one had apical disease. histol ... | 1986 | 3757564 |
| symmetrical peripheral gangrene in disseminated tuberculosis. | we report the case of a 66-year-old man who developed a symmetrical peripheral gangrene (spg) on both feet during disseminated miliary tuberculosis. mycobacterium tuberculosis was not only isolated from sputum, gastric juice, and urine, but also from a blood culture. since a disseminated intravascular coagulopathy was very likely to be excluded, it is possible that the spg was due to embolization of arterioles by the tubercle bacilli. the literature of spg is reviewed and the different possible ... | 1986 | 3770263 |
| the effect of exposure of hospital employees to patients with tuberculosis on dermal reactivity to four new tuberculins. | an early (6-8 h) erythematous response to purified protein derivative and to sonicate antigens (new tuberculins) prepared from mycobacterium tuberculosis, m. vaccae, m. scrofulaceum, and m. leprae occurred much more frequently amongst hospital employees exposed to patients with tuberculosis than amongst factory workers. biopsies taken from the skin test sites at 48 h revealed a more intense inflammatory cell infiltrate in response to ppd and the sonicate of m. tuberculosis, but not to the antige ... | 1986 | 3775860 |
| pelvic tuberculosis: an uncommon gynaecological problem in malaysia. | tuberculosis of the genital tract was diagnosed in only 12 patients during the 17 year period from march 1968 to february 1985 at the university hospital, kuala lumpur, which serves as a major referral centre in malaysia. the incidence was 0.31 per 1000 gynaecological admissions and the peak age incidence was in the age group 26 to 35 years. the surgical management was mainly conservative as infertility was the most frequent mode of presentation (50%). evidence of previous pulmonary tuberculosis ... | 1986 | 3783810 |
| bone tuberculosis: results and experience in leicestershire. | management of tuberculosis falls to the thoracic physician and includes extrapulmonary sites. we have conducted a survey of notification of bone tuberculosis in leicestershire from 1978 to 1983 inclusive. eighty-one cases were notified, 75 were traced and 69 confirmed tuberculosis (mean age 40.2 years, 39 male, 54 from the indian sub-continent (isc)). mean length of symptoms was 8.4 months, the commonest being pain and swelling. the diagnosis was established by evidence of bone involvement plus ... | 1986 | 3790417 |
| tuberculosis and the acquired immunodeficiency syndrome at a new york city hospital: 1978-1985. | recent reports have described an increase in cases of tuberculosis in several urban centers. to investigate the possible relationship between tuberculosis and the acquired immunodeficiency syndrome (aids), we reviewed case records at a new york city hospital between 1978 and 1985. during this period, tuberculosis occurred in 15.1 percent of aids patients with a history of parenteral drug use and 4.4 percent of all other patients with aids. the yearly rate of tuberculosis more than doubled during ... | 1987 | 3802929 |
| effects of diet and genetics on mycobacterium bovis bcg vaccine efficacy in inbred guinea pigs. | strain 2 and strain 13 guinea pigs were vaccinated with mycobacterium bovis bcg and placed on low-protein or protein-adequate diets. five weeks later all animals were infected by the respiratory route with virulent mycobacterium tuberculosis h37rv organisms. four weeks postchallenge, guinea pigs were skin tested with purified protein derivative and sacrificed. protein deficiency resulted in significant reductions in body weight and thymus weight and in an impairment in the ability to control the ... | 1987 | 3804439 |
| the spectrum of pneumonia in 1983 at the riyadh armed forces hospital. | the agents causing pneumonia have been assessed in 112 adult patients admitted to the armed forces hospital in riyadh during a period of one year: pathogens were identified in 78 patients (69.6%). sputum culture produced a significant isolate in 60 patients (53.5%), and in 17 (15.2%) the causative agent was suggested by serological tests. streptococcus pneumonia was the commonest infecting agent (21.4%). pneumonia due to mycobacterium tuberculosis was diagnosed in eight patients, to mycoplasma p ... | 1987 | 3819456 |
| atypical community-acquired pneumonia: concurrent infection with chlamydia psittaci and mycobacterium tuberculosis. | we have presented a case of combined pulmonary infection with chlamydia psittaci and mycobacterium tuberculosis, both documented by culture of lymph nodes and respiratory secretions. we describe it not only as an unusual occurrence, but also to illustrate the importance of a systematic and thorough diagnostic approach to every case of pneumonia. | 1987 | 3824037 |
| laboratory evaluation of a new long-acting 3-azinomethylrifamycin fce 22250. | fce 22250 (3-(n-piperidinomethylazino)methylrifamycin sv) is a member of the new class of 3-azinomethylrifamycins characterized by a long persistance in animals, a good oral absorption and a broad antibacterial spectrum including mycobacteria. in the experimental mice infection sustained by mycobacterium tuberculosis h37rv, fce 22250 shows an efficacy 14 times higher than rifampicin and is still therapeutic when administered once every three weeks. | 1985 | 3839503 |
| immune responses to hepatitis b virus and tuberculosis infections in southeast asian refugees. | both mycobacterium tuberculosis and hepatitis b virus infections are common in the philadelphia southeast asian refugee population. among 224 hepatitis b carriers identified between january 1, 1982 and march 31, 1984, there was a statistically significant association between a negative tuberculin skin test (purified protein derivative (ppd)) and viral replication (hepatitis b e antigen positivity (hbeag)). this finding suggests that bacille calmette guérin (bcg) vaccination might reduce the prev ... | 1985 | 3877457 |
| chronic relapsing experimental allergic encephalomyelitis in the lewis rat. | chronic relapsing experimental allergic encephalomyelitis (cr-eae) was induced in rats with an emulsion of guinea-pig spinal cord tissue (gpsc) in complete freund's adjuvant (cfa) enriched with mycobacterium tuberculosis h37ra (tbc). 78% of the sensitized rats developed a cr-eae showing 2 to 3 clinical relapses during the first 40 days. after 60-80 days, approximately half of the rats with cr-eae had a further relapse which was followed by complete recovery in only 35% of the cases. the remainin ... | 1985 | 3877741 |
| biodistribution of 64cu in inflamed rats following administration of two anti-inflammatory copper complexes. | 64cu was administered in two anti-inflammatory formulations to normal rats and to rats with 2 forms of local inflammation, namely (a) an acute paw oedema (elicited with carrageenan) or (b) a chronic granulomatous response to an implanted irritant (mycobacterium tuberculosis in a polyurethane sponge). the copper formulations used were (i) a slow release one consisting of cu(ii) salicylate applied dermally with ethanol/dmso and (ii) short acting hydrophilic complex (cu(i)cu(ii)-penicillamine)5- gi ... | 1985 | 3878667 |
| fatty acid biosynthesis in mycobacterium tuberculosis var. bovis bacillus calmette-guérin. purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-coa with methylmalonyl-coa. | a crude extract from mycobacterium tuberculosis var. bovis bacillus calmette-guérin was previously shown to incorporate methylmalonyl-coa into mycocerosic acids, exemplified by 2,4,6,8-tetramethyloctacosanoic acid, and malonyl-coa into n-fatty acids (rainwater d. l., and kolattukudy, p. e. (1983) j. biol. chem. 258, 2979-2985). the presence of several fatty acid synthases with differences in substrate preference and product chain length was detected in the crude extract of m. tuberculosis var. b ... | 1985 | 3880746 |
| short-course chemotherapy for pulmonary infection due to mycobacterium bovis. | three residents of the open door mission of omaha developed pulmonary infections due to mycobacterium bovis. all were alcoholics with malnutrition. the disease was most likely due to reactivation of a primary infection acquired at least 30 years earlier in the index case. both of the secondary patients had been treated more than ten years previously for infections due to mycobacterium tuberculosis. supervised short-course chemotherapy was effective in treating the disease caused by mycobacterium ... | 1985 | 3885893 |
| in vitro delayed hypersensitivity granuloma formation: development of an antigen-coated bead model. | previously, we have described an in vitro model of granulomatous hypersensitivity around schistosoma mansoni eggs in both the murine model of schistosomiasis and in human schistosomiasis. these studies describe a new model of in vitro granuloma formation that complexes soluble egg antigen from s. mansoni eggs, a partially purified protein derivative of mycobacterium tuberculosis (ppd), or bovine serum albumin to carrier beads. ultrastructural and morphologic evaluations demonstrate that there ar ... | 1985 | 3886798 |
| the role of lumbar puncture in the evaluation of dementia: the durham veterans administration/duke university study. | the use of lumbar puncture (lp) and cerebrospinal fluid (csf) analysis in the routine, initial evaluation of patients with dementia continues to be questioned. this is especially true in the investigation of infectious causes of dementia. to explore this question further, the authors performed a retrospective analysis of 672 hospitalized patients specifically evaluated for dementia. lp and csf analysis were performed on 402 patients (60 per cent); routine bacteriologic, acid-fast, and fungal cul ... | 1985 | 3889117 |
| changing etiology of nosocomial bacteremia and fungemia and other hospital-acquired infections. | serial surveys on the etiology of nosocomial bacteremia have been conducted over a period of years at boston city hospital (boston) and grady memorial hospital (atlanta). a comparison of the information from these surveys with that from single-period surveys at 10 other hospitals in the united states illustrates changes in the etiology of nosocomial bloodstream infection over the past five decades. prominent trends include an increased frequency of episodes of polymicrobial bacteremia, an increa ... | 1985 | 3901203 |
| [malignant lymphoma and tuberculosis]. | in 153 patients with malignant lymphoma (1981-1984) one case of simultaneous occurrence of a non-hodgkin lymphoma of high grade malignancy and tuberculosis of a cervical lymph node is reported. typical morphological characteristics were absent. in the first biopsy mycobacterium tuberculosis was demonstrated in a microbiological animal trial. in a second biopsy a centroblastic lymphoma was found. it is possible that the onset of lymph node tuberculosis is promoted by the impaired immunological de ... | 1985 | 3910983 |
| tuberculous pseudotumour of the liver developing during antituberculous chemotherapy. | a 29-year-old chinese woman presented with a liver mass 2 months after initiation of chemotherapy for disseminated tuberculosis. a percutaneous liver biopsy revealed tuberculous pseudotumour. although acid-fast bacilli were seen in the biopsy specimen, no organism could be cultured. no changes were made in the antituberculous chemotherapy, and the mass subsequently resolved. the patient was still well 18 months after presentation. to the authors' knowledge, the features of tuberculous pseudotumo ... | 1985 | 3917349 |
| use of the bactec system for drug susceptibility testing of mycobacterium tuberculosis, m. kansasii, and m. avium complex. | a total of 199 mycobacterium tuberculosis, 182 m. kansasii, and 32 m. avium complex isolates were tested for susceptibility to either three or 10 color-coded drugs in a four-phase study using the conventional 7h10 plate method and the bactec system. agreement between the two test systems for m. tuberculosis isolates against isoniazid, ethambutol, and rifampin was 96%; it was 93.6% against all 10 drugs. disagreement was highest for ethionamide and cycloserine. m. kansasii data were encouraging, w ... | 1985 | 3917885 |
| nonphagocytic dendritic cells are effective accessory cells for anti-mycobacterial responses in vitro. | the accessory cell requirements for a given t cell response may be examined in vitro by using highly purified lymph node t cells. we have examined the capacity of different antigen-presenting cells to stimulate proliferation of mycobacterium tuberculosis-primed t cells when the antigenic challenge is either soluble or particulate in nature. by titrations of cell number and antigen concentration, it was shown that dendritic cells are not only extremely efficient at presenting soluble mycobacteria ... | 1985 | 3918113 |
| guinea-pig inoculation and culture for mycobacterium tuberculosis in infertile women. a study of cost-effectiveness. | endometrial biopsy (eb) specimens obtained from infertile women at natalspruit hospital are routinely subjected to histological examination, culture for tubercle bacilli and guinea-pig inoculation (gpi). a retrospective analysis of 103 eb specimens from natalspruit hospital and 255 specimens from private patients (in the greater johannesburg area) examined during january 1981 - august 1983 revealed a 1,96% overall incidence of endometrial tuberculosis (tb). the incidence of endometrial tb in inf ... | 1985 | 3918350 |
| arthroscopy in septic arthritis. lidocaine- and iodine-containing contrast media are bacteriostatic. | puncture of septic foci is usually performed to determine the responsible bacteria. if contrast medium is used instead of saline to rinse the lesion and to withdraw an adequate bacteriologic specimen, the opacification provides valuable information about the extent of the changes. since lidocaine is usually used as a local anesthetic when patients undergo this procedure, we tested the in vitro antibacterial effects of lidocaine 1%, as well as those of 2 contrast media--meglumine amidotrizoate an ... | 1985 | 3918544 |
| role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a t lymphocyte line in rats. | adjuvant arthritis is an experimental disease of rats induced by immunization to antigens of mycobacterium tuberculosis. our observation that arthritis could be induced in irradiated rats by the a2 line of t lymphocytes in the absence of mycobacterial antigens suggested that adjuvant arthritis is an autoimmune disease. moreover, the a2 line could be used to vaccinate unirradiated rats against the subsequent induction of adjuvant arthritis by active immunization to mycobacteria. in the present st ... | 1985 | 3919059 |
| subdivision of mycobacterium tuberculosis for epidemiological purposes: a seven year study of the "classical' and 'asian' types of the human tubercle bacillus in south-east england. | human strains of mycobacterium tuberculosis were divided into the 'classical' and 'asian' types according to their sensitivity to thiophen-2-carboxylic acid hydrazide. the isolation of these two types in south-east england was studied during a seven-year period (1977-1983). the 'asian' type was more prevalent among ethnic asian patients than among ethnic europeans. among europeans there was a decline in the isolation rate of 'classical' strains and a small but significant increase in 'asian' str ... | 1985 | 3919087 |
| in vitro antituberculosis activity of a new antibacterial substance ofloxacin (dl8280). | a new antituberculosis agent, ofloxacin (dl8280), inhibited the growth of mycobacterium tuberculosis at concentrations of 0.63 to 1.25 micrograms/ml. there were no cross-resistance relationships between this agent and other antituberculosis agents. the agent delayed the growth rate of m. tuberculosis (strain h37rv) at concentrations of 0.2 to 0.5 microgram/ml. it showed considerable bactericidal activity at concentrations a little higher than the growth-inhibitory concentration. the combined eff ... | 1985 | 3919625 |
| i-a restricted activation by t cell lines of anti-tuberculosis activity in murine macrophages. | tuberculosis and leprosy remain two of the world's most significant diseases. immunity involves the activation of macrophages by lymphokines but the details are unknown because there has been no objective assay for the relevant effector function using human pathogens. we previously reported the use of tritiated-uracil uptake by surviving mycobacteria as a measure of the anti-mycobacterial effect of human monocytes. we describe here the use of a modification of this assay to measure control of th ... | 1985 | 3919979 |
| efficacy of three mycobacterial antigens in the serodiagnosis of tuberculosis. | three different antigens were tested for detection of mycobacterial antibodies. the 3 antigens were mycobacterial saline extract (mse), mycobacterial sonicate (mso) and ppd. for detection, both the soluble antigen fluorescent antibody (safa) and the enzyme-linked immunosorbent assay (elisa) tests were used. we used 88 serum samples (50 from clinically, radiologically and/or bacteriologically proven cases of tuberculosis, 8 from proven cases of leprosy and 30 from healthy controls). with mse anti ... | 1985 | 3920068 |
| in-vitro inhibition of mycobacteria by viridans streptococci. | eleven strains of mycobacterium tuberculosis and 13 other species of mycobacteria were examined for susceptibility to 26 strains of viridans streptococci. susceptibility was detected by the simultaneous antagonism technique, but not by tests of deferred antagonism. it is concluded that in-vitro inhibition of mycobacterial growth by actively growing streptococci is due to a peroxide-mediated antagonism which is too variable to be of value for identification. however, a standard bactericidal test ... | 1985 | 3920400 |
| fixation of mycobacterium leprae in unstained smears prior to shipment or storage: evaluation of formaldehyde using mycobacterium tuberculosis as indicator of efficacy. | | 1985 | 3920468 |
| [use of irritating inhalations for the detection of bacteria in patients with silicotuberculosis]. | | 1985 | 3920652 |
| [primary colon tuberculosis]. | two cases of primary gastrointestinal tuberculosis are reported. one patient showed radiologic, colonoscopic and histopathologic features of crohn's disease. after a five-year follow-up, acid-fast bacilli were identified in colonic tissue cultures. in both patients fecal cultures were repeatedly negative for mycobacterium tuberculosis. the two patients were successfully treated with antituberculous therapy. the authors emphasize the importance of considering tuberculosis in patients presenting w ... | 1985 | 3920754 |
| bacteriologically confirmed pulmonary tuberculosis in childhood. clinical and radiological features. | over a 4-year period 185 cases of pulmonary tuberculosis in children were confirmed by culture of mycobacterium tuberculosis, usually from gastric aspirate. the majority of cases occurred in boys (62%) and the younger age groups were more commonly affected--26% of patients were less than 1 year old and 65% less than 3 years of age. at the time of presentation 40% of the 151 children tested had a negative tuberculin test. a chest radiograph was available in 136 cases. the commonest changes seen w ... | 1985 | 3920765 |
| [comparison of tuberculosis cutis luposa and cutaneous leishmaniasis]. | we present a comparative study concerning two cases of tuberculosis cutis luposa and cutaneous leishmaniasis, respectively. these two turkish female patients had suffered from changes of the facial skin since 20 years (tuberculosis cutis luposa) and for 5 months (cutaneous leishmaniasis). the tuberculosis cutis luposa had been misdiagnosed as cutaneous leishmaniasis and surgically treated. both cases showed an apple jelly-like color at the edges of the lesions with soft tissue. with tuberculosis ... | 1985 | 3920838 |
| determination of in vitro susceptibility of mycobacterium tuberculosis to cephalosporins by radiometric and conventional methods. | among eight cephalosporins and cephamycins tested in preliminary in vitro screening against mycobacterium tuberculosis, the most promising for further study was found to be ceforanide, followed by ceftizoxime, cephapirin, and cefotaxime. moxalactam, cefoxitin, cefamandole, and cephalothin were found to be not active enough against m. tuberculosis to be considered for further in vitro studies. the antibacterial activity of various ceforanide concentrations was investigated by three methods: (i) t ... | 1985 | 3920957 |
| pulmonary tuberculosis in residents of lodging houses, night shelters and common hostels in glasgow: a 5-year prospective survey. | despite a high prevalence of pulmonary tuberculosis in the vagrant population in large cities, this group is reluctant to accept chest radiograph screening and outpatient chemotherapy. in order to improve the response rate, inducements were given for chest radiographic examinations between 1978 and 1982 to residents in lodging houses, night shelters, common hostels in glasgow. the response rate improved and 133 cases of active pulmonary tuberculosis were found. of these, 63% had positive sputum ... | 1985 | 3921049 |
| radiometric selective inhibition tests for differentiation of mycobacterium tuberculosis, mycobacterium bovis, and other mycobacteria. | in the context of a busy reference laboratory, radiometric selective inhibition tests were evaluated for rapid differentiation of mycobacterium tuberculosis and mycobacterium bovis and of the m. tuberculosis complex from other mycobacteria. p-nitro-alpha-acetylamino-beta-hydroxypropiophenone at 5 micrograms and hydroxylamine hydrochloride at 62.5 and 125 micrograms per ml of 7h12 medium were used to separate the m. tuberculosis complex from other mycobacteria (mott bacilli). since it is importan ... | 1985 | 3921561 |
| evaluation of the p-nitro-alpha-acetylamino-beta-hydroxypropiophenone differential test for identification of mycobacterium tuberculosis complex. | the p-nitro-alpha-acetylamino-beta-hydroxypropiophenone (nap) differential test for the identification of mycobacterium tuberculosis recovered from clinical specimens was evaluated by two laboratories and found to be a rapid and accurate procedure with a specificity exceeding 99%. | 1985 | 3921563 |
| mycobacterium tuberculosis bacteremia detected by the isolator lysis-centrifugation blood culture system. | mycobacterium tuberculosis was detected by the isolator lysis-centrifugation blood culture system from the blood of a patient with tuberculosis of the breast. the organism also grew on conventional laboratory media inoculated with pleural fluid from the patient. | 1985 | 3921564 |
| [pulmonary tuberculosis with negative sputum smear. approaches and perspectives]. | | 1985 | 3921786 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 22-1985. an 88-year-old man with weight loss and a large pleural effusion. | | 1985 | 3921843 |
| [role of the l form in the persistence of pathogenic bacteria]. | | 1985 | 3922153 |
| peroxidase-mediated oxidation of isoniazid. | oxidation of isonicotinic acid hydrazide (isoniazid) by horseradish peroxidase at the expense of h2o2 yielded reactive species which were able to reduce nitroblue tetrazolium and bleach p-nitrosodimethylaniline. nicotinic acid hydrazide oxidation did not cause these effects. at slightly alkaline ph, oxidation of isonicotinic acid hydrazide by horseradish peroxidase proceeded at the expense of molecular o2, and the reaction was oxygen consuming. the addition of h2o2 abolished o2 consumption. bovi ... | 1985 | 3922297 |
| effects of the methanol extraction residue (mer) tubercle bacillus fraction on the production of antibodies in vitro. iii. consequence of prior sensitization to mer. | mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (mer) in incomplete freund's adjuvant produced high titers of circulating antibodies against mer, as assessed by the enzyme-linked immunosorbent assay (elisa) method. spleen cells derived from these animals failed to respond to the usual nonspecific immunopotentiating influence of mer on the primary production of antibodies (generation of specific plaque-forming cells) in vitro to sheep red blood cells. t ... | 1985 | 3922630 |
| diagnosis of ileocecal and colonic tuberculosis by colonoscopy. | the colonoscopic findings in 11 proven cases of ileocecal tuberculosis consisted of deformed ileocecal valve in all 11 and contracted cecal lumen in 10. this was associated with mucosal nodules predominantly around the ileocecal valve, pseudopolypoid folds, and mucosal protuberance. two patients had an isolated cecal ulcer. in three of the 11 patients the examination enabled a histologic diagnosis to be made on the basis of typical granuloma. in the other four patients mycobacterium tuberculosis ... | 1985 | 3922847 |
| detection of an antigen (my4) common to m. tuberculosis and m. leprae by 'tandem' immunoassay. | a novel 'tandem' immunoassay for the detection of mycobacterial antigen was devised using a monoclonal antibody (ml 34) both as solid phase 'capture' and as the 125i- or enzyme-labelled 'tracer' antibody. this antibody binds to the repeating epitopes (my4b) of a water-soluble protease-resistant antigen from m. tuberculosis, m. leprae and some other species of mycobacteria. optimal binding results could be obtained within 4 h by the consecutive incubation of ml34-coated microtitre plates with ant ... | 1985 | 3923119 |
| [pyrazinamidase activity and sensitivity to pyrazinamide in tuberculosis bacteria]. | | 1985 | 3923467 |
| [value of microbiological studies in the diagnosis of ocular tuberculosis]. | | 1985 | 3923468 |
| [generalized tuberculosis in a child, caused by l forms of mycobacterium tuberculosis]. | | 1985 | 3923469 |
| [clinical manifestations and treatment of respiratory organ tuberculosis in children caused by mycobacterium bovis]. | | 1985 | 3923470 |
| augmentation of anti-tumor activity by immunization with mycobacterium tuberculosis (tbc) and tuberculin-coupled tumor cells. | the anti-tumor effect of immunization with heat-killed mycobacterium tuberculosis (tbc) and tuberculin (ppd)-coupled syngeneic tumor cells was examined in vivo. three tumor cell lines were employed. immunization of tbc-primed balb/c mice with ppd-coupled syngeneic meth-a tumor cells displayed a potent anti-tumor effect on viable meth-a cells inoculated subcutaneously. neither ppd-coupled llc (lewis lung carcinoma) cells nor sonicated ppd-coupled meth-a cells were capable of immunizing these mice ... | 1985 | 3923781 |
| techniques of dna hybridization detect small numbers of mycobacteria with no cross-hybridization with non-mycobacterial respiratory organisms. | the traditional methods used in identifying mycobacteria, such as acid-fast bacillus stains and culture, are often time-consuming, insensitive, and nonspecific. as part of an ongoing program to improve diagnosis and characterization of mycobacteria, we have found that deoxyribonucleic acid (dna) hybridization techniques using isotopically labeled, single-stranded, total dna can be used to detect as little as 10(-4) micrograms of mycobacterium tuberculosis (mtb) dna. this amount of dna represents ... | 1985 | 3923880 |
| non-specific protection against pulmonary legionella pneumophila infection in guinea-pigs immunized and challenged with mycobacteria. | experiments were designed to test the ability of the non-specific efferent limb of cell mediated immunity (cmi) to protect guinea-pigs against a lethal l. pneumophila challenge. a secondary cmi response was generated in the lungs of guinea-pigs using an established protocol which consisted of intraperitoneal infection with mycobacterium bovis bcg followed by intravenous infection with mycobacterium tuberculosis h37ra. the animals were challenged with l. pneumophila (100 ld50) by the aerosol rout ... | 1985 | 3924087 |
| [use of mycobacterium tuberculosis antigen 5 in the diagnosis of active pulmonary tuberculosis with elisa technic]. | | 1985 | 3924532 |
| granuloma formation by muramyl dipeptide associated with branched fatty acids, a structure probably essential for tubercle formation by mycobacterium tuberculosis. | muramyl dipeptide, which does not induce epithelioid granuloma when injected alone dissolved in phosphate-buffered saline, could induce extensive granulomas in guinea pigs when chemically conjugated with branched, but not linear, fatty acids. peptidoglycan fragments of staphylococcus epidermidis could evoke epithelioid granulomas when incorporated in a water-in-oil emulsion. these findings suggest the importance of a lipid bound to muramyl dipeptide for granuloma formation. in view of the fact t ... | 1985 | 3924828 |
| evaluation of the bactec radiometric method for detection of 1% resistant populations of mycobacterium tuberculosis. | bactec and conventional methods of antimicrobial susceptibility testing were compared with the use of artificial mixtures of 1% resistant and 99% susceptible mycobacterium tuberculosis strains. inocula for the assays were prepared on the basis of radiometric readings. a total of 40 resistant strains were tested: 18 were resistant to isoniazid, 16 to rifampin, 5 to streptomycin, and 1 to ethambutol. the bactec method detected 27 of 39 strains at the greater than 0.5% resistance level, whereas the ... | 1985 | 3924952 |
| [mycobacterium tuberculosis cultures in mycobacterium 7h11 agar versus löwenstein-jensen medium]. | the mycobacteria 7h11 agar medium has ben compared with the löwenstein-jensen medium for the growth of mycobacterium tuberculosis. fifty five strains of m. tuberculosis isolated from different clinical specimens in sivas have been used in this study. thirty two of them grew on the mycobacteria 7h11 agar within ten days but only 26 grew on the löwenstein-jensen medium. | 1985 | 3925304 |
| [studies on pyrazine derivatives. xvi. antitubercular properties of compound f-369 in in vitro and in vivo studies]. | | 1985 | 3925442 |
| [clinico-epidemiological aspects of sparse and single detection of m. tuberculosis]. | | 1985 | 3925452 |
| [effectiveness of a fast culture method for mycobacteria as a therapeutic control and within the scope of diagnosis]. | a rapid method for culturing mycobacteria using a liquid medium and a rotating incubator was applied in routine examinations parallel with the conventional methods. as therapy control the rapid method appeared unsuitable, for the cultures are checked by microscopy and during therapy there is a period in which mycobacteria are visible but not multiplying. within the diagnostics results are available somewhat earlier but the efficiency of the rapid culture is less than with the method in general u ... | 1985 | 3925651 |
| infection and disease among contacts of tuberculosis cases with drug-resistant and drug-susceptible bacilli. | three hundred ninety-eight tuberculosis patients with tubercle bacilli resistant to isoniazid and/or streptomycin were matched by age, race, sex, and geographic area to an equal number of patients with tubercle bacilli susceptible to 9 drugs, including isoniazid and streptomycin, in an effort to determine whether the risk of infection and disease among contacts of patients with resistant bacilli is different from the risk among contacts to patients with susceptible bacilli. the risk of infection ... | 1985 | 3925826 |
| lung allograft rejection in the rat. v. inhaled stimuli aggravate the rejection response. | responses to inhaled stimuli in lung allografts might intensify the rejection response against the grafts. therefore, we investigated the rejection of lung allografts in rats exposed to various degrees of stimuli via the airways. a group of these rats was selectively decontaminated to eliminate infection of the graft. stimuli provided were intrabronchially injected purified protein derivative in sensitized rats and dust inhaled from sawdust used as bedding in the cages. both intrabronchially inj ... | 1985 | 3925827 |
| periodic acid-schiff reaction stains mycobacterium tuberculosis, mycobacterium leprae, mycobacterium ulcerans, mycobacterium chelonei (abscessus), and mycobacterium kansasii. | | 1985 | 3925927 |
| [epidemiology and etiology of acute infections of the lower respiratory tract]. | | 1985 | 3925966 |
| tuberculoid bacilli and tuberculoidosis. | | 1985 | 3926397 |
| tuberculin (tb) skin testing after exposure. | | 1985 | 3926684 |
| superficial tuberculous lymphadenitis in merseyside: 1969-1984. | the aetiology, epidemiology and clinical presentation of 137 bacteriologically confirmed cases of superficial mycobacterial lymphadenitis identified at the liverpool public health laboratory between 1969 and 1984 were reviewed. despite a fall in pulmonary and total extrapulmonary isolates, the annual recovery of mycobacteria from lymph nodes remained relatively constant. mycobacterium tuberculosis was the cause of infection in 121 patients (88.3%), m. bovis in 6 and the remaining 10 isolates wer ... | 1985 | 3926870 |
| necrotic inflammatory reaction induced by muramyl dipeptide in guinea pigs sensitized by tubercle bacilli. | in the course of studies aimed at determining whether mdp was antigenic or not, a hitherto unreported phenomenon was noticed. injection (a provocative injection) of muramyl dipeptide (mdp) caused severe inflammation, with hemorrhage and necrosis in the footpads of guinea pigs, where tubercle bacilli in water-oil emulsion (a preparatory injection) had been injected 3-8 wk earlier. sometimes the reaction was accompanied by generalized and fatal shock. several related substances were tested, and on ... | 1985 | 3926935 |
| taxonomic studies on the mycobacterium tuberculosis series. | numerical classification of slowly growing mycobacteria, including 159 strains received as mycobacterium tuberculosis, m. bovis, m. africanum, and m. microti, was carried out using 88 characters, and the following results were obtained. 1) all 159 strains received as m. tuberculosis, m. bovis, m. africanum, and m. microti formed one cluster, and no clear-cut differentiation among four species was achieved. these four species should be reduced to one species, m. tuberculosis. 2) within the cluste ... | 1985 | 3927118 |
| [antitubercular properties of erythromycin a cyclic 11,12-carbonate in experiments in vitro and in vivo]. | | 1985 | 3927273 |
| upper airway obstruction due to tuberculosis. treatment by photocoagulation. | we describe here a case of endotracheobronchial tuberculosis involving both the trachea and major bronchi. endobronchial carcinoma was suspected initially, even at the time of bronchoscopy. later, despite improvement of the pulmonary infiltrate and clinical symptoms after chemotherapy, upper airway obstruction occurred. repeat bronchoscopy showed a distal tracheal nongranulomatous, fibrogranular stenotic lesion. laser therapy was then employed to reduce the stenosis. | 1985 | 3927276 |
| [pyrazinamidase of m. tuberculosis. possibility of testing sensitivity to pyrazinamide]. | | 1985 | 3927281 |
| arthritis induced by a t-lymphocyte clone that responds to mycobacterium tuberculosis and to cartilage proteoglycans. | adjuvant arthritis characterized by chronic inflammation of the joints of rats is induced by immunization to mycobacterium tuberculosis. to learn how autoimmune arthritis may be caused by a microbial antigen, we isolated a t-lymphocyte clone specific for m. tuberculosis antigens that was strongly arthritogenic. we now report that the clone recognized, in addition to m. tuberculosis antigens, antigens present in human synovial fluid, medium of chondrocyte cultures, and proteoglycans purified from ... | 1985 | 3927297 |
| characterization of the specificity of monoclonal antibodies against mycobacterium tuberculosis by crossed immunoelectrophoresis. | the specificity of monoclonal antibodies against mycobacterium tuberculosis was determined by crossed immunoelectrophoresis. radiolabelled, non-precipitating monoclonal antibody was incorporated in the top gel together with unlabelled polyvalent, precipitating anti-bacillus calmette-guérin (bcg) antibody. inclusion of labelled antibody in individual precipitate lines was demonstrated by autoradiography. each monoclonal antibody was localized in a single precipitate line: antibody tb73 reacted wi ... | 1985 | 3927476 |
| culture of mycobacterium tuberculosis from non-fixed sputum smears. | smears prepared from sputum species were kept in the dark at 4 degrees c or at 20-25 degrees c. cultures for mycobacteria were carried out on these smears 0, 4, 8, and 15 days later and the results compared with those of cultures made from the sputum specimen on the day of collection. the percentage of negative cultures from originally positive specimens was high, and use of the method is not considered advisable. there is an additional risk of infection for laboratory staff when handling unfixe ... | 1985 | 3927541 |
| primary drug-resistant tuberculosis in children. correlation of drug-susceptibility patterns of matched patient and source case strains of mycobacterium tuberculosis. | the purpose of this study is to compare the drug-susceptibility patterns of mycobacterium tuberculosis isolated from patients (children) and from their corresponding adult contacts. we wished to ascertain if the susceptibility pattern of the isolate from the adult contact could be used as a guide in the initial selection of the antituberculous drug regimen in the child. strains resistant to one or more antituberculous drugs were emphasized in our study. for 120 children with positive cultures, a ... | 1985 | 3927707 |
| alteration of ribosomes and rna polymerase in drug-resistant clinical isolates of mycobacterium tuberculosis. | the biochemical mechanism of resistance to kanamycin, viomycin, and rifampin in five clinical isolates of mycobacterium tuberculosis was studied. resistance to viomycin and kanamycin was attributed to altered ribosomes, whereas resistance to rifampin was attributed to an alteration of rna polymerase. ribosomal resistance was, however, not the only way of expressing resistance to viomycin and kanamycin. | 1985 | 3927838 |
| isolation and geographic distribution of mycobacterium other than m. tuberculosis in british columbia, 1972-81. | it has been suggested that the incidence of infection with mycobacteria other than typical tubercle (mott) bacilli is increasing. laboratory and epidemiologic information relating to mott infection in british columbia between 1972 and 1981 was analysed. patient records for 1960-81 were also analysed. of the 313 661 laboratory specimens 13 474 yielded mycobacterium tuberculosis isolates and 3172, mott isolates. over the 10 years the number of m. tuberculosis isolates declined, whereas the absolut ... | 1985 | 3928125 |
| enzyme-linked immunosorbent assay using mycobacterium tuberculosis antigen 5 and ppd for the serodiagnosis of tuberculosis. | enzyme-linked immunosorbent assays (elisa) of immunoglobulin g antibody to mycobacterium tuberculosis antigen 5 and tuberculin purified protein derivative (ppd) were assessed for the serodiagnosis of tuberculosis in 41 patients with active tuberculosis, 19 patients with inactive tuberculosis, and 59 healthy control subjects. patients with active tuberculosis were studied serially at monthly intervals following the initiation of therapy. when contrasted with our earlier studies of sera from patie ... | 1985 | 3928278 |
| rifampicin for non-tuberculous infections? | large populations of rifampicin-sensitive strains of mycobacterium tuberculosis have been exposed in vitro to changing concentrations of rifampicin (rif) in line with changes in the blood level of the drug observed during treatment, and to much lower concentrations. experiments in which the organism was exposed to either 7 or 14 days of cyclically-changing rifampicin concentrations have resulted in the elimination of the m. tuberculosis test strains without the emergence of rif resistance. the s ... | 1985 | 3928283 |
| isoenzyme patterns of mycobacteria. i. factors influencing ldh isoenzymes of mycobacteria. | cell free extracts of a fast growing mycobacterium (m. phlei) and a slow growing mycobacterium (m. tuberculosis h37ra) were analysed for lactate dehydrogenase (ldh) isoenzymes under different experimental conditions. it was observed that growth of m. phlei when taken from lowenstein jensen (lj) as well as sauton's medium showed identical band but for (m. tuberculosis h37ra the number of bands observed were less when grown on lj-medium. there was no difference in ldh isoenzyme patterns when the m ... | 1985 | 3928774 |
| [changes in the prevalence of drug-resistant tuberculosis from 1972 to 1982]. | | 1985 | 3928959 |
| [biological effects of new pas derivatives on mycobacterium tuberculosis]. | a new series of p-aminosalicylic acid derivatives were tested in vitro against myc.tbc. h37rv strain and clinically isolated pathogenic mycobacteria. 4 - [alpha - (benzylamino - thiocarbonylthio) - acetamido] - salicylic acid was most active, 4 - [alpha - methyl - alpha - (furfurylamino - thiocarbonylthio) - acetamido] - salicylic acid was more active than pas. 4 - [alpha - (ethylamino - thiocarbonylthio) - acetamido] - salicylic acid, and 4 - [alpha - methyl - alpha - (ethylamino - thiocarbonyl ... | 1985 | 3929034 |
| transmission of mycobacterium tuberculosis with renal allografts. | disseminated tuberculosis occurred in 2 allograft recipients of kidneys procured on the same donor. both recipients were treated by low dose prednisolone and azathioprine, and one of them was on a special protocol including antilymphocyte globulins as rejection prophylaxis. none of them experienced acute rejection. the early posttransplant period was uneventful except for the occurrence of mild viral infections in both cases (herpes simplex virus in case 1 and cytomegalovirus in case 2). 2 and 6 ... | 1985 | 3929153 |
| tuberculous fistula of cheek. report of a case. | a case of tuberculous fistula of the cheek is reported. the fistula was caused primarily by a carious tooth and was infected with tubercle bacilli present in the sputum of the patient, who had pulmonary tuberculosis. | 1985 | 3929200 |
| male genital tuberculosis: a review of the literature with instructive case reports. | the prevalence of extrapulmonary tuberculosis, including cases at male genital sites, has remained relatively constant during the past two decades in the united states. the most common genital sites of tuberculous infection are the epididymis and prostate; the testicle is infected in a lower proportion of cases. the usual modes of genital involvement include descending infection from the kidneys, intracanalicular or direct extension from neighboring foci in the genital tract, and hematogenous se ... | 1985 | 3929355 |
| [characteristics of the protein complexes of clinical strains of mycobacteria]. | the protein composition of mycobacterium tuberculosis and the molecular weight of proteins contained in these organisms have been determined by the method of electrophoresis in the porosity gradient of polyacrylamide gel. close similarity between the electrophoregrams of m. tuberculosis clinical and laboratory strains has been revealed. the study of 18 strains of different groups of mycobacteria has shown that m. tuberculosis are essentially different from opportunistic mycobacteria and acid-res ... | 1985 | 3929502 |
| microscopic evaluation of sputum specimens submitted for mycobacterium tuberculosis culture. | using microscopic screening criteria employed in the study of sputum in acute bacterial pneumonia, the authors evaluated 644 sputum samples from 347 patients submitted for mycobacterial bacterial culture. after microscopic examination, these specimens were processed using standard mycobacterial laboratory technics. salivary specimens accounted for 67.1% of the samples evaluated, and yielded 13 of the total 42 mycobacterium tuberculosis isolates, as well as 4 of the 21 smear-positive culture-posi ... | 1985 | 3929590 |
| determination of in vitro susceptibility of mycobacteria to ansamycin. | the in vitro susceptibility of different mycobacterial species to ansamycin (lm427) in concentrations of 2.0, 1.0, 0.5, and 0.2 micrograms/ml was determined by the agar dilution method. for those strains of m. tuberculosis and m. avium complex tested, susceptibility to ansamycin was compared with susceptibility to rifampin. all m. tuberculosis strains susceptible to rifampin were susceptible to ansamycin; the strains that were highly resistant to rifampin also were resistant to ansamycin. the ma ... | 1985 | 3929660 |
| effect of methanol extraction residue tubercle bacillus fraction treatment in vivo and in vitro on the release and activity of suppressor factor inhibiting the efferent phase of contact sensitivity in mice. | balb/c mice subjected to injection of dinitrobenzenesulfonate (dnbso3) and skin painting with dinitrofluorobenzene (dnfb) produce splenic t-suppressor (ts) cells that, when transferred to dnfb-sensitized recipients, suppress the efferent (eff) phase of contact sensitivity (cs). splenocyte populations containing such ts-eff cells release a specific soluble suppressor factor (ssf) in vitro that similarly suppresses cs in sensitized recipient mice. treatment with the methanol extraction residue (me ... | 1985 | 3930076 |
| gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. | recombinant human gamma interferon (rifn-gamma) was examined for its ability to activate human peripheral blood monocyte-derived macrophages to kill tumor cells and to affect the replication of two phylogenetically distinct intracellular pathogens, mycobacterium tuberculosis and leishmania donovani. macrophages preincubated overnight with doses of rifn-gamma from 5 to 500 u/ml killed [3h]thymidine-labeled mouse l929 tumor targets, as measured by the release of [3h]thymidine into the supernatant ... | 1985 | 3930401 |
| mycolipenates and mycolipanolates of trehalose from mycobacterium tuberculosis. | analysis of the lipids of mycobacterium tuberculosis, by thin-layer chromatography, revealed the presence of two families of novel glycolipids each having two closely-related members but differing widely in polarity. the least and most polar families of lipids were characterized from m. tuberculosis strains c and h37rv, respectively; all were based on trehalose, the least polar pair of glycolipids having more long-chain substituents than the more polar pair. the acyl substituents of the least po ... | 1985 | 3930656 |
| detection of mycobacterial antigen and antibodies in the cerebrospinal fluid of patients with tuberculous meningitis. | an immunodiagnostic test for the detection of a soluble nonprotein mycobacterial antigen by reverse passive haemagglutination with igm murine monoclonal antibody was developed. the test was used to analyse the cerebrospinal fluid of 89 patients with tuberculous meningitis (tbm) from india and 127 control subjects from india and the uk. the antigen was demonstrable in 88% of culture-positive and 73% of culture-negative tbm patients. however, it was also detected in 21% of indian patients with pyo ... | 1985 | 3930746 |
| [evaluation of early results of treatment of pulmonary tuberculosis in mycobacterium-positive patients. comparison of the results of 3- and 4-drug treatment]. | | 1985 | 3931056 |
| [61 years' survival of koch's bacillus in a closed focus. disclosure in a case of spinal cord compression caused by sequelae of pott's disease]. | a 68 year-old woman presented with a spinal cord compression from an angular kyphosis due to pott's disease at age 7. clinical, radiological and pathological studies of the vertebral lesions did not demonstrate an evolutive lesion. however, culture yielded some viable koch's bacilli. this bacteriologic confirmation 61 years later exemplifies the importance of host immunity reactions, that may prevent the development of kb, and the remarkable capacity of survival of the bacillus. | 1985 | 3931195 |
| [resistance of mycobacterium tuberculosis. an 8-year survey in the poitiers area]. | we have studied in poitiers area from 1977 to 1984 the resistance of 853 mycobacterium tuberculosis strains to the main anti-tuberculosis drugs. the overall rate of drug resistance was showed to be steady over the years while the primary resistance rate has decreased. the only one drug resistance has concerned para-aminosalicylic acid, streptomycin and isoniazid. foreigners, most of them asian people or north-african people, often bear resistant tubercle bacilli (29,03%) compared with french peo ... | 1985 | 3931200 |