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findprobe: a computer program to locate potential probe sequences in dna. 20061426575
perinatal care and cost effectiveness: changes in health expenditures and birth outcome following the establishment of a nurse-midwife program.estimates of infant health status and expenditures for perinatal care are presented for periods of time before and after implementation of a nurse-midwife program in rural georgia. as the program developed, the infant mortality rate of the four counties served by the program showed a decrease. similarly, the target population (pregnant women of low to moderate income who had no private physician) experienced decreases in the rate of neonatal mortality, low birthweight, and short gestational age. ...1998107372
ultrasonic visualization of wirsung's duct: dream or reality?ultrasonic visualization of normal and pathological wirsung's ducts has become quite common, especially with the newest gray scale units. ductal images were studied in 17 cases of quiescent chronic pancreatitis. duct dilatation could be identified in the majority1998108297
[vasodilator therapy of heart failure]. 1998108068
[infection in biliary surgery. per and post-operative bacteriological study (author's transl)]. 1998107009
phase changes of cardiolipin vesicles mediated by divalent cations.small unilamellar vesicles were prepared from cardiolipin and produced the hexagonal ii phase when dialyzed against cacl2 or mgcl2. upon removal of the cation by dialysis against edta large unilamellar vesicles were formed. the events of the transition from the lamellar to hexagonal phase and back to the lamellar phase are described.1998106890
rising health care costs: a schism between medicine and business? 199997049
the assessment of thyroid function and structure. 199999712
[secondary coronary fistulas].these fistulae are very rare: 8 to 11 p. 100 of all coronary fistulae. three types are recognised: right coronaro-ventricular, left coronaro-ventricular, and coronao-pulmonary. the two first types are found most frequently in association with a sigmoid atresia on the orifice, and with ventricular hypoplasia in the presence of a functional atrio-ventricular valve. the fistula then serves as a means of ventricular ejection. of the secondary fistulae, the right coronaro-ventricular type is the most ...199996769
[hungarian-made titanium-polyamide knee joint prosthesis]. 199917789
substrate specificity of hexosaminidase a isolated from the liver of a patient with a rare form (ab variant) of infantile gm2 gangliosidosis and control tissues. 199996668
[oral administration of nasal mucosa decongestants]. 199993766
differentiation of normal pressure hydrocephalus and cerebral atrophy by computed tomography and spinal infusion test.the diagnostic value of computed tomography (ct) and spinal infusion test (sit) was investigated in 27 patients with normal pressure hydrocephalus (nph) and 35 patients with cerebral atrophy. the most consistent ct finding of nph was dilatation of the temporal horns, that of cerebral atrophy widening of the convexity sulci. however, 43% of patients with cerebral atrophy demonstrated no cortical atrophy. the sit showed an excellent relation with isotope cisternography and continuous intracranial ...199993629
hurler/scheie phenotype. report of an inbred sibship with tapeto-retinal degeneration and electron-microscopie examination of the conjuctiva.an inbred sibship with corneal opacities and deficient alpha-l-iduronidase activity showed signs of a hurler/scheie phenotype. the children were of normal intelligence. in one of the children, electron microscopy of the conjunctiva showed membrane-bound intracellular vacuoles and the electroretinogram was extinguished. the consanguinity of the parents is taken to indicate the presence of homozygosity of a mutant gene different from both the hurler and scheie mutants, thus rejecting the concept o ...199996404
aylmer francis foster-carter. 199984314
antitoxin treatment of tetanus.a random study of 300 cases suffering from tetanus was conducted at the lady reading hospital peshawar. three groups each of hundred patients were formed depending on the dose of a.t.s. administered. no particular difference was noted in the mortality of groups receiving 100,000 units and 20,000 units. a dose of 20,000 units is thus sufficient for most of the tetanus cases. 1000,000 units a.t.s. may be given to postpartum and abortion cases where the infection is more generalised and severe.199996286
antibodies to sarcocystis in malaysians.sera from 243 donors belonging to the four main ethnic groups in west malaysia (orang asli, malays, chinese and indians) were tested, using the indirect fluorescent antibody technique for the prevalence of antibodies to sarcocystis. almost 20% reacted positively at dilutions of 1:64 or higher and eight among the orang asli and malays gave the highest titres of 1:256. prevalence was highest in the orang asli and lowest in chinese. 22 sera also reacted positively to toxoplasma, whether due to poly ...200097821
deafness due to hypervitaminosis d. 200087663
antibiotic tolerance in producer organisms. 200094753
[significance of clearance values in advanced renal insufficiency (author's transl)].under physiological conditions there is satisfactory agreement between the clearance values of endogenous creatinine and inulin in humans. in chronic renal insufficiency the endogenous creatinine clearance cannot be considered as an index for glomerular filtrate because of considerable individual variations. in spite of this limitation endogenous creatinine clearance proves to be a sensitive test for hospital and general practice to estimate the loss of renal function in chronic progressive rena ...2000101802
[improving the economic effectiveness of the operations of pharmaceutical institutions]. 200098347
therapeutic evaluation of various drugs in giardiasis (a comparative trial). 2000101765
[increased demethylation of aminopyrine under long-term treatment with anticonvulsive drugs (author's transl)].demethylation of aminopyrine was measured in 25 healthy controls and 19 epileptics on long-term treatment with anticonvulsants by the 14c-aminopyrine breath test. compared to controls epileptics exhibited increased cumulative 14co2-exhalation rates (88.7% at 30 min, 62.6% at 2 h and 24.8% at 8h) following ingestion of 2 mu ci 14c-aminopyrine. the results suggest that long-term treatment with antiepileptic drugs results in increased demethylating function of the liver which can be easily detected ...200097469
psychiatric manifestations of organic diseases. 20001220951
phencyclidine and ketamine intoxication: a study of four populations of recreational users. 2000101865
deep vein thrombosis. 200097405
[stenosis and intestinal ulcer due to chronic ingestion of a combination of a thiazidic diuretic with potassium].reports from recent years shown evidence of the existence of a type of primary ulceration of the small bowel associated with stenosis, relatively frequent and possibly iatrogenic. the primary characteristics of the studied cases were that it was present in patients over 50 years old, a good number of them had cardiorenal diseases or were hypertensives, and ingestion of a thiazide diuretic supplemented with potassium. clinical and experimental investigations suggest that potassium, with or withou ...200097150
radiation from implantable nuclear pacemakers. ii. analysis. 200195300
flashbacks: ventricular fibrillation. part ii. 200195229
[radioimmunologic determination of alpha fetoprotein in high risk pregnancies]. 200190481
esophageal atresia, duodenal atresia, and gastric distention: report of two cases. 200197973
infertility in a potto. 200197850
problems of classification of low-back pain. 2002139668
the bender gestalt: use of clinical judgment versus recall scores in prediction in huntington's disease. 2002130390
[malignant pheochromocytoma in the organ of zuckerkandl]. 2002130307
chlorpromazine photoallergy. coexistence of immediate and delayed type.a 54-year-old woman had a recurrent pruritic eruption in light-exposed areas. she had a combination of three types of hypersensitivity to chlorpromazine, ie, allergic contact dermatitis, photocontact dermatitis, and immediate allergic photosensitivity. immediate wheal reactions were found after long-wave ultraviolet light irradiation at photopatch test and intradermal injection sites with chlorpromazine. these responses were differentiated from phototoxic reactions. a positive passive transfer r ...2002128322
relation of the fibrinolytic to other biological systems. 2002128149
[medical synchrocyclotron proton tract of the leningrad institute of nuclear physics]. 2002127916
mouth-operated devices for handicapped persons.a mouth-operated device designed for paralyzed persons was described. this device enables invalid persons to perform simple, everyday actions. the uses and advantages of the instrument as compared to other types were discussed.2002127837
[massive dose methotrexate with citrovorum factor rescue: mtx-pharmacokinetics, excretion pattern, and techniques for safety administration (author's transl)]. 2003317293
lumbar spinal canal stenosis. 2003262526
circular dichroic properties and conformation of thionicotinamide dinucleotides.the spectroscopic properties of the 3-thioamide analogues of coenzymes nad and nadh (snad and snadh) have been investigated in order to obtain information about their conformational properties. in particular, ultraviolet absorption and circular dichroism properties of solutions in phosphate buffer ph 7 and ethanol were studied. also equimolar mixtures of amp and snmn(h), obtained by cleaving the coenzymes with phosphodiesterase, were investigated using the same solvents. the appearance of a coup ...2003204482
vagal body tumor (nonchromaffin paraganglioma, chemodectoma, and carotid body-like tumor) with cervical node metastasis and familial association: ultrastructural study and review.a case of a vagal body tumor with a solitary cervical node metastasis is described. there was a remarkable familial association: a biopsy-proven paraganglioma occurred in two members of the patient's family and there was a strong clinical suspicion of a paraganglioma in two others. in a review of the literature, eight patients with metastasizing vagal body tumors and eight patients in whom the vagal body tumor was a component of multicentric presentation of paragangliomas were found. only one ot ...2003187317
unique training in developmental disabilities for senior dental hygiene students. 2003161977
an overview of immune aging.a brief overview of the effect of age on the function of cells of the immune system is presented. normal immune functions can begin to decline shortly after an individual reaches sexual maturity. foremost among the cellular changes are those in the stem cells as reflected in their growth properties and the availability of precursor t cells, and in the t cell where a shift in subpopulations may be occurring. present evidence indicates that thymic involution precedes and therefore may be responsib ...2003155761
indications for the sterilisation of the handicapped adolescent. 2003152033
relief of seizures from a predominantly posterior temporal tumor with anterior temporal lobectomy.we report the relief of intractable complex partial seizures in a patient with a posteromesial temporal lobe hamartoma after anterior temporal lobectomy, despite minimal tumor removal. we suggest that the key to successful treatment is the mainly medial, or limbic, location of the tumor, which apparently requires anterior limbic structures for full clinical expression of seizures. we conclude that excision anterior to a posterior temporal lesion can result in seizure relief and that a medial tum ...20032792031
[people's commissariat of public health of the rsfsr and the establishment of public health in the union republics]. 2003150046
intercarpal fusion for treatment of carpal instability: a preliminary report.post-traumatic instability was once considered to be a rare but important injury recognized among the various carpal trauma. however, recent literature suggests that reports on this entity are increasing in number. methods of treatment for this injury were few in the past and were not well established. following the lesson of 2 cases of failure with open reduction and ligamentous reconstruction, 4 such cases were treated by intercarpal fusion; 3 had no pain or tenderness at a follow-up period of ...2004535218
[isolated thrombosis of the deep femoral vein]. 2004470589
response from menhaden fish meal in diets of young turkeys.diets involving three or five fish meal treatments and two zinc bacitracin treatments were fed to 5410 poults. the poults were divided into 552 pens and raised to two, three or four weeks of age in five series of 3 x 2 or 5 x 2 factorial experiments. body weights increased 9.0 to 31.3% from the addition of 5% menhaden fish meal and 5.4 to 11.9% from the addition of 44 ppm bacitracin. no interaction existed between fish meal and bacitracin. residues derived from either water or petroleum ether ex ...2004514950
congenital pulmonary artery branch stenosis: association with renal artery stenosis.a patient had multiple bilateral stenoses of the pulmonary artery and its branches with systemic hypertension associated with mild stenoses of the renal arteries. cardiac catheterization and angiocardiography are important in the evaluation of the degree of stenoses and pulmonary hypertension. this case suggests that in a child or young person with hypertension and a loud precordial murmur, lesions other than coarctation of the aorta may be present. unexplained systemic hypertension requires fur ...2004421591
[should the mentally handicapped be sterilized?]. 2004436057
relationship of serum aluminum to serum creatinine and parathyroid hormone in chronic renal failure and transplant patients. 2004356040
platelet aggregation: methodology and physiopathology.the physiopathological role of platelet aggregation in some thromboembolic and atherosclerotic complications is strongly suggested on the basis of many indirect findings. the qualitative methodological approach to this problem generally used until recently is rapidly giving way to a quantitative, biochemical approach. platelet aggregation, however, even if expressed in terms of nanomoles of a product obtained in a sophisticated reaction system, will continue to deceive investigators and clinicia ...2004381008
in memoriam. walter westbrook robinson, m.d. 1893-1977. 2004331396
mechanism of mitotic synchronization induced by 5-aminouracil. 20051253843
[modification of the capillary flow of interdental papillae using massage with a stream of water]. 20051168613
[obstructive cardiomyopathy. a new surgical method of treatment].a case of treatment of obstructive cardiomyopathy by insertion of a disc mistral prosthesis (cooley's technique) is reported. the result obtained was satisfactory from a clinical, haemodynamic and angiocardiographic standpoint. the mode of action of this technique is discussed.20051168899
influence of regenerative capacity and innervation on oncogenesis in the adult frog (rana pipiens).twenty-two sarcomas were induced in 19 adult frogs (rana pipiens) treated with 3-methylcholanthrene pellets. thirteen of these tumors arose first in a denervated forelimb, and only 2 arose first in normal or nerve-supplemented control forelimbs (p = 0.004). the remaining tumors developed either as a second tumor in a tumor-bearing frog or in hindlimbs. the critical role of innervation in regenerative capacity suggests that the predilection to tumor formation in the denervated limbs may have resu ...20051087345
[spontaneous hemobilia in the differential diagnosis of upper gastrointestinal hemorrhages].hemobilia, biliary tree hemorrhage, is characterized by melana and/or haematemesis, biliary colic and clinical jaundice. the rare cause of gastrointestinal bleeding probably accounts for quite a large percentage of gastrointestinal hemorrhages of undetermined source. in the evaluation of gastrointestinal bleeding the hepato-biliary system is seldom examined unless trauma has occurred. however, 10-15% of cases with hemobilia are non-traumatic. three cases are presented illustrating three differen ...20051087461
[immunoblastic lymphadenopathy and toxacariasis. report of a case].this is a report of a case a larval granulomatosis associated with immunoblastic lymphadenopathy, corroborated by laboratory and histologic studies compatible with that. the etiopathogenesis, clinical picture and diagnosis of both diseases are commented, and the possible relationship between them is stressed.20051087413
ada standards for dental prepayment programs. 20051064930
[reduction of orthophosphates in the secondary effluent from an activated sludge treatment plant by combined chemical and bacteriological actions]. 2005554124
oil spill studies: strategies and techniques. 2005547011
[biliary hamartomas (apropos of a case)]. 2005538831
nifedipine reduces the incidence of myocardial infarction and transient ischemia in patients undergoing coronary bypass grafting.a randomized study was performed on 104 patients undergoing elective coronary artery bypass grafting to examine whether the infusion of nifedipine (n = 53) reduces the incidence of perioperative myocardial ischemia and necrosis in the early postoperative period. continuous hemodynamic and three-channel holter monitoring was performed for 24 hours and serial assessment of serum enzymes and 12-lead electrocardiography were performed for 36 hours postoperatively. nifedipine (minimum dose, 10 microg ...20061899365
nifedipine reduces the incidence of myocardial infarction and transient ischemia in patients undergoing coronary bypass grafting.a randomized study was performed on 104 patients undergoing elective coronary artery bypass grafting to examine whether the infusion of nifedipine (n = 53) reduces the incidence of perioperative myocardial ischemia and necrosis in the early postoperative period. continuous hemodynamic and three-channel holter monitoring was performed for 24 hours and serial assessment of serum enzymes and 12-lead electrocardiography were performed for 36 hours postoperatively. nifedipine (minimum dose, 10 microg ...20061899365
[acute febrile polyarthritis disclosing horton's disease]. 20061828585
[acute febrile polyarthritis disclosing horton's disease]. 20061828585
effects of sex steroids on skin 5 alpha-reductase activity in vitro.skin 5 alpha-reductase activity is the major factor influencing the manifestation of androgen excess. although oral contraceptives have been useful for the treatment of androgen excess, little is known of the independent effects of the various progestins and estrogens on inhibition of skin 5 alpha-reductase activity. we incubated minces of normal genital and pubic skin with physiologic concentrations of 3h-testosterone to assess 5 alpha-reductase activity by its conversion to 3h-dihydrotestoster ...20061828548
effects of sex steroids on skin 5 alpha-reductase activity in vitro.skin 5 alpha-reductase activity is the major factor influencing the manifestation of androgen excess. although oral contraceptives have been useful for the treatment of androgen excess, little is known of the independent effects of the various progestins and estrogens on inhibition of skin 5 alpha-reductase activity. we incubated minces of normal genital and pubic skin with physiologic concentrations of 3h-testosterone to assess 5 alpha-reductase activity by its conversion to 3h-dihydrotestoster ...20061828548
the e2f transcription factor is a cellular target for the rb protein.although it is generally believed that the product of the retinoblastoma susceptibility gene (rb1) is an important regulator of cell proliferation, the biochemical mechanism for its action is unclear. we now show that the rb protein is found in a complex with the e2f transcription factor and that only the under phosphorylated form of rb is in the e2f complex. moreover, the adenovirus e1a protein can dissociate the e2f-rb complex, dependent on e1a sequence also critical for e1a to bind to rb. the ...20061828392
the e2f transcription factor is a cellular target for the rb protein.although it is generally believed that the product of the retinoblastoma susceptibility gene (rb1) is an important regulator of cell proliferation, the biochemical mechanism for its action is unclear. we now show that the rb protein is found in a complex with the e2f transcription factor and that only the under phosphorylated form of rb is in the e2f complex. moreover, the adenovirus e1a protein can dissociate the e2f-rb complex, dependent on e1a sequence also critical for e1a to bind to rb. the ...20061828392
acute and chronic effects of parathion and 2,4 d on the oxygen consumption of chasmagnathus granulata (decapoda, brachyura).the effect of two pesticides widely used in argentina on the oxygen consumption of the estuarine crab chasmagnathus granulata was studied. constant pressure respirometers were employed to estimate the rate of oxygen consumption per weight unit of animals treated previously with each pesticide, both acute (96 h) and chronically (15 and 30 days). crabs exposed to parathion -an organophosphorate insecticide that causes the inhibition of acetylcholinesterase- show an increase of oxygen consumption a ...20061797200
acute and chronic effects of parathion and 2,4 d on the oxygen consumption of chasmagnathus granulata (decapoda, brachyura).the effect of two pesticides widely used in argentina on the oxygen consumption of the estuarine crab chasmagnathus granulata was studied. constant pressure respirometers were employed to estimate the rate of oxygen consumption per weight unit of animals treated previously with each pesticide, both acute (96 h) and chronically (15 and 30 days). crabs exposed to parathion -an organophosphorate insecticide that causes the inhibition of acetylcholinesterase- show an increase of oxygen consumption a ...20061797200
differential modulation of monoamine levels and turnover rates by estrogen and/or androgen in hypothalamic and vocal control nuclei of male zebra finches.sexual behaviors, including singing, in male zebra finches are under the combined control of androgens and estrogens. treating castrates with androstenedione (ae), a hormone which provides both androgenic and estrogenic metabolites, restores catecholamine (ca; i.e., norepinephrine (ne) and dopamine (da] function in brain areas known to be involved in the control of these behaviors. since these behaviors can only be activated by the combined action of androgens and estrogens, the present study de ...20061698105
[richard larsson wrote courage to live. bookseller started a new life in the health service. interview by christina mörk]. 20062095088
diverticuloplasty for severe mucosal injury after cricopharyngeal myotomy.cricopharyngeal myotomy with either diverticulopexy or diverticulectomy is the recommended therapy for zenker's diverticulum. mucosal injury during myotomy is rare and usually can be managed by direct mucosal closure. a technique is described to repair a serious mucosal defect that may occur during cricopharyngeal myotomy.20061540077
n-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production.tnf is a major mediator in the pathogenesis of endotoxic shock, and its inhibition has a protective effect in various animal models of sepsis or endotoxin (lipopolysaccharide, lps) toxicity. lps treatment also induces an oxidative damage mediated by increased production of reactive oxygen intermediates. n-acetylcysteine (nac) is an antioxidant and a precursor of the synthesis of glutathione (gsh) and was reported to protect against lps toxicity and lps-induced pulmonary edema. in this study we i ...20061544168
use of the polymerase chain reaction to isolate an s-locus glycoprotein cdna introgressed from brassica campestris into b. napus ssp. oleifera.a self-incompatible canola-quality brassica napus ssp. oleifera line (w1) was generated by introgressing the s-locus from a self-incompatible b. campestris plant into the westar cultivar. using the polymerase chain reaction (pcr) with primers derived from conserved regions in s-locus glycoprotein (slg) alleles, the central region of the active slg gene (910) was obtained. the remaining portions of the cdna for this 910 gene were subsequently cloned using the pcr-rapid amplification of cdna ends ...20061508146
problems imposed by the new technology. 20061458757
health checks on patients 75 years and over in nottinghamshire after the new gp contract.to investigate annual health checks for patients of 75 years and over required by the 1990 contract for general practitioners.20061393076
the cellular and molecular biology of membrane transport. aps conference. orlando, florida, november 4-7, 1992. abstracts. 20061360685
adjuvant treatment in breast cancer. 20061346675
the proteins of poliovirus. 20061317596
[renal tubular acidosis]. 20072293263
[renal tubular acidosis]. 20072293263
diagnosis of ectopic pregnancy by vaginal ultrasonography in combination with a discriminatory serum hcg level of 1000 iu/l (irp)the diagnostic value of vaginal sonography in combination with a discriminatory serum hcg level of 1000 iu/l (international reference preparation) was tested prospectively in 200 pregnant women suspected of having an ectopic pregnancy. an ectopic pregnancy was diagnosed in 68 women (34%), a miscarriage in 56 (28%) and a normal pregnancy in 76 (38%). on admission, an intrauterine sac was seen in 89% of the intrauterine pregnancies, but in none of the ectopic pregnancies. detection of an adnexal m ...20072223681
diagnosis of ectopic pregnancy by vaginal ultrasonography in combination with a discriminatory serum hcg level of 1000 iu/l (irp)the diagnostic value of vaginal sonography in combination with a discriminatory serum hcg level of 1000 iu/l (international reference preparation) was tested prospectively in 200 pregnant women suspected of having an ectopic pregnancy. an ectopic pregnancy was diagnosed in 68 women (34%), a miscarriage in 56 (28%) and a normal pregnancy in 76 (38%). on admission, an intrauterine sac was seen in 89% of the intrauterine pregnancies, but in none of the ectopic pregnancies. detection of an adnexal m ...20072223681
differential scanning calorimetry study of mixed-chain phosphatidylcholines with a common molecular weight identical with diheptadecanoylphosphatidylcholine.to examine the thermotropic phase behavior of various mixed-chain phosphatidylcholines in excess water and to compare it with the known behavior of identical-chain phosphatidylcholines, we have carried out high-resolution differential scanning calorimetric (dsc) studies on aqueous dispersions of 10 different mixed-chain phosphatidylcholines. these lipids, c(16):c(18)pc, c(18):c(16)pc, c(15):c(19)pc, c(19):c(15)pc, c(14):c(20)pc, c(20):c(14)pc, c(13):c(21)pc, c(21):c(13)pc, c(12):c(22)pc, and c(2 ...20072223759
differential scanning calorimetry study of mixed-chain phosphatidylcholines with a common molecular weight identical with diheptadecanoylphosphatidylcholine.to examine the thermotropic phase behavior of various mixed-chain phosphatidylcholines in excess water and to compare it with the known behavior of identical-chain phosphatidylcholines, we have carried out high-resolution differential scanning calorimetric (dsc) studies on aqueous dispersions of 10 different mixed-chain phosphatidylcholines. these lipids, c(16):c(18)pc, c(18):c(16)pc, c(15):c(19)pc, c(19):c(15)pc, c(14):c(20)pc, c(20):c(14)pc, c(13):c(21)pc, c(21):c(13)pc, c(12):c(22)pc, and c(2 ...20072223759
[comparative evaluation of clinical and economic effectiveness of preventive therapy of affective and schizoaffective psychoses].the authors provide the results of a comparative study into the action of different drug approaches to the prevention of relapses of affective and schizoaffective psychoses with the aid of multifactorial consideration of different clinical, economic and socioeconomic indicators characterizing the "benefits and losses" because of the use of carbamazepine and lithium carbonate. the comparative analysis has shown a high normothymic activity of carbamazepine and lithium carbonate in the patients exa ...20072176049
primary repair vs. colostomy for the treatment of colon injuries. 20072323289
normal metabolism of debrisoquine and theophylline in a slow tolbutamide metaboliser.the metabolism of debrisoquine and theophylline has been studied in a healthy male who was identified as a slow hydroxylator of tolbutamide. tolbutamide clearance in this subject was three-fold lower than the lowest tolbutamide clearance observed in other healthy males and the drug's half-life was approximately three-fold longer. despite this, his ability to 4-hydroxylate debrisoquine and both n-demethylate and 8-hydroxylate theophylline was normal. along with previously published information th ...20073864428
normal metabolism of debrisoquine and theophylline in a slow tolbutamide metaboliser.the metabolism of debrisoquine and theophylline has been studied in a healthy male who was identified as a slow hydroxylator of tolbutamide. tolbutamide clearance in this subject was three-fold lower than the lowest tolbutamide clearance observed in other healthy males and the drug's half-life was approximately three-fold longer. despite this, his ability to 4-hydroxylate debrisoquine and both n-demethylate and 8-hydroxylate theophylline was normal. along with previously published information th ...20073864428
design of 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde as a reagent for ultrasensitive determination of primary amines by capillary electrophoresis using laser fluorescence detection.amino acids and peptides, from both standard solutions and biological samples, were successfully reacted with 3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde, at low concentration, to form highly fluorescent isoindole derivatives. the formed mixtures are effectively separated by high-performance capillary electrophoresis and their constituents detected by their laser-induced fluorescence signals. the minimum detectable quantities in the low attomole (10(-18) mol) range are encountered.20072064006
carbohydrate feedings 1 h before exercise improves cycling performance.the effects of consuming two different amounts of liquid carbohydrate 1 h before exercise on the metabolic responses during exercise and on exercise performance were determined. subjects consumed either 1.1 g (lc) or 2.2 g (hc) carbohydrate/kg body mass or a placebo (p). subjects cycled at 70% of maximal oxygen consumption (vo2max) for 90 min and then underwent a performance trial. blood glucose and insulin responses during exercise were different among the three trials. total carbohydrate oxida ...20071951158
120-hour 5-fluorouracil (5-fu) continuous infusion (ci) plus bcnu in advanced colorectal cancer.seventy-five previously untreated patients with measurable advanced colorectal cancer were treated with 5 fluorouracil 1,000 mg/m2 as a 24-hour intravenous (i.v.) continuous infusion during days 1-5 and 28-32 every cycle, plus 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu), 200 mg/m2 i.v. bolus on day 1, all given every 8 weeks up to 6 cycles. median karnofsky performance status (kps) was 100. sites of disease at entry were mainly the abdomen (45%) and liver (33%). all patients were evaluable for r ...20071951175
hospice day care.hospice day care is a cost-effective way to expand the range of services available to hospice patients and families. additionally, day care can increase continuity of care between inpatient and homecare settings, and ease the burden of responsibility on the homecare component of hospice.20072361094
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