| down-regulation of na/k+ atpase activity by human parvovirus b19 capsid protein vp1. | human parvovirus b19 (b19v) may cause inflammatory cardiomyopathy (icmp) which is accompanied by endothelial dysfunction. the b19v capsid protein vp1 contains a lysophosphatidylcholine producing phospholipase a2 (pla) sequence. lysophosphatidylcholine has in turn been shown to inhibit na(+)/k(+) atpase. the present study explored whether vp1 modifies na(+)/k(+) atpase activity. | 2013 | 23689698 |
| human parvoviruses b19, parv4 and bocavirus in pediatric patients with allogeneic hematopoietic sct. | among the immunocompetent, infections with parvovirus b19 (b19v) and human bocavirus (hbov) 1 range clinically from asymptomatic to severe, while following allogeneic hematopoietic sct (hsct) b19v can cause a persistent severe illness. the epidemiology and clinical impact of hbov1 and the other emerging parvovirus 4 (parv4) among immunocompromised patients have not been established. to determine the occurrence and clinical spectrum of b19v, parv4 and hbov1 infections, we performed a longitudinal ... | 2013 | 23686097 |
| post-infectious acute glomerulonephritis and transient coagulation factor xiii deficiency associated with acute parvovirus b19 infection in a young woman--reply. | | 2013 | 23683879 |
| post-infectious acute glomerulonephritis and transient coagulation factor xiii deficiency associated with acute parvovirus b19 infection in a young woman. | | 2013 | 23683878 |
| acute viral myocarditis: current concepts in diagnosis and treatment. | acute myocarditis is one of the most challenging diseases to diagnose and treat in cardiology. the true incidence of the disease is unknown. viral infection is the most common etiology. modern techniques have improved the ability to diagnose specific viral pathogens in the myocardium. currently, parvovirus b19 and adenoviruses are most frequently identified in endomyocardial biopsies. most patients will recover without sequelae, but a subset of patients will progress to chronic inflammatory and ... | 2013 | 23662385 |
| evidence for the continued transmission of parvovirus b19 in patients with bleeding disorders treated with plasma-derived factor concentrates. | | 2013 | 23659532 |
| absence of evidence of parvovirus b19 transmission by plasma-derived clotting concentrates derived from b19v nucleic acid technology-tested plasma and including effective steps for the inactivation or removal of nonenveloped viruses. | | 2013 | 23659531 |
| long-term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia: a review. | perinatal survival rates after intrauterine transfusions (iut) for red cell alloimmunisation now exceed 90%, which demonstrates the safety and efficacy of one of the most successful procedures in fetal therapy. however, improved perinatal survival could lead to an increased number of children with long-term disabilities. the importance of long-term follow-up studies in fetal therapy lies in both the necessity of evaluation of antenatal management as well as in evidence-based preconceptional and ... | 2013 | 23658134 |
| bone lesions in an infant with congenital parvovirus b19 infection. | bone lesions on radiographs of newborns often suggest congenital infections. skeletal roentgenograms are recommended in the evaluation of suspected congenital syphilis, but bone lesions have been recognized in other congenital infections. we report the case of an infant with hydrops fetalis secondary to congenital parvovirus b19 infection who was found to have bone lesions in multiple long and axial bones on admission to the neonatal icu. both the infant and her mother were evaluated for other c ... | 2013 | 23610199 |
| [liver involvement and parvovirus b19 infection in healthy adults]. | | 2013 | 23597570 |
| the determinants for the enzyme activity of human parvovirus b19 phospholipase a2 (pla2) and its influence on cultured cells. | human parvovirus b19 (b19v) is the causative agent of erythema infectiosum in humans. b19 infection also causes severe disease manifestations, such as chronic anemia in immunocompromised patients, aplastic crisis in patients with a high turnover rate of red blood cells, and hydrops fetalis in pregnant women. although a secreted phospholipase a2 (pla2) motif has been identified in the unique region of the b19v minor capsid protein vp1(vp1u), the determinants for its enzyme activity and its influe ... | 2013 | 23596524 |
| rhabdomyolysis associated with human parvovirus b19 infection in a patient with fukuyama-type congenital muscular dystrophy. | patients with fukuyama-type congenital muscular dystrophy sometimes experience transient exacerbations of muscle weakness. we took care of a 9-year-old boy with fukuyama-type congenital muscular dystrophy who presented with acute respiratory failure and decreased exercise ability with marked elevation of serum creatine kinase indicating rhabdomyolysis. at that time, his younger sister suffered from erythema infectiosum. although he had no particular symptoms, he was tested and proven to have acu ... | 2014 | 23594821 |
| the effects of co-infection with human parvovirus b19 and plasmodium falciparum on type and degree of anaemia in ghanaian children. | to determin the extent to which parvovirus b19 (b19v) and co-infection of b19v and malaria contribute to risk of anaemia in children. | 2013 | 23593592 |
| frequent occurrence of parvovirus b19 dnaemia in the first year after kidney transplantation. | described for the first time in 1986, parvovirus b19 (b19v) infection in kidney transplant recipients remains little-known and probably underestimated. the aims of this study were to establish b19v infection frequency during the first year after kidney transplant and to determine predisposing factors and manifestations of the infection in renal transplant recipients. sixty consecutive adult patients, transplanted less than a year before, were included in this study. b19v and other opportunistic ... | 2013 | 23588740 |
| retrospective evaluation of antibody index of human parvovirus b19 as a prognostic factor in patients with dilated and ischemic cardiomyopathy. | cardiotropic viral infections are important causative factors in dilated cardiomyopathy. this retrospective study examined the antibody index for human parvovirus b19 in patients suffering from dilated or ischemic cardiomyopathy as a prognostic factor for stable left ventricular function. blood specimens from 43 patients with the diagnosis of dilated or ischemic cardiomyopathy were analyzed for human parvovirus b19 by polymerase chain reaction (pcr) and enzyme immunoassay kit for qualitative det ... | 2013 | 23588739 |
| preemptive intravenous immunoglobulin allows safe and timely administration of antineoplastic therapies in patients with multiple myeloma and parvovirus b19 disease. | parvovirus b19 (b19) disease is a rare cause of anemia in cancer patients and often goes unrecognized, causing delays in anticancer therapy. | 2013 | 23578205 |
| human parvovirus b19 ns1 protein aggravates liver injury in nzb/w f1 mice. | human parvovirus b19 (b19) has been associated with a variety of diseases. however, the influence of b19 viral proteins on hepatic injury in sle is still obscure. to elucidate the effects of b19 viral proteins on livers in sle, recombinant b19 ns1, vp1u or vp2 proteins were injected subcutaneously into nzb/w f1 mice, respectively. significant expressions of inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2) were detected in nzb/w f1 mice receiving b19 ns1 as compared to those mi ... | 2013 | 23555760 |
| papular-purpuric gloves and socks syndrome due to parvovirus b19: a report of two simultaneous cases in cohabitant families. | the so-called papular-purpuric gloves and socks syndrome (ppgss) is a condition characterized by acute onset of intense erythema, edema and petechiae with a typical localization on the hands and feet, besides mucosal lesions of the oral cavity. the syndrome has a favorable and self-limited course, requiring only a symptomatic therapy. in the 50% of the cases described in literature (ninety cases in 22 years), is documented an acute infection caused by parvovirus b19 and in only two cases the ons ... | 2013 | 23550259 |
| [human bocavirus and its current epidemic status in china]. | human bocavirus (hbov) is classified in the family of parvovirdae, genus bocavirus. besides parvovirus b19 and human parvovirus 4 (parv4), hbov isone of the parvoviruses currently known to infect and cause illness in human. so far, four different hbovs (hbov1-4) have been successively reported. the incidence of hbovs infection varies widely, the clinical presentations of patients are different, and hbovs are often co-detected with other pathogens. there are already quite a few report of hbovs in ... | 2013 | 23547381 |
| analysis about the influence on the fetus infected with parvovirus b19 using amniotic erythropoietin and troponin-t. | we tried to identify the influence on the fetus infected with parvovirus b19 (pb19) and retrospectively analyze the severity of fetal infection. | 2013 | 23525596 |
| pure red cell aplasia following autoimmune hemolytic anemia: an enigma. | a 26-year-old previously healthy female presented with a 6-month history of anemia. the laboratory findings revealed hemolytic anemia and direct antiglobulin test was positive. with a diagnosis of autoimmune hemolytic anemia (aiha), prednisolone was started but was ineffective after 1 month of therapy. a bone marrow trephine biopsy revealed pure red cell aplasia (prca) showing severe erythroid hypoplasia. the case was considered prca following aiha. this combination without clear underlying dise ... | 2015 | 23525059 |
| severe warm autoimmune haemolytic anaemia due to anti-jk(a) autoantibody associated with parvovirus b19 infection in a child. | | 2013 | 23522895 |
| increased il-6 detection in adult and pediatric lymphoid tissue harboring parvovirus b19. | parvovirus b19 (b19v) is a common pathogenic virus infecting humans. previous studies have shown evidence of b19v infection in patients with non-hodgkin's lymphoma (nhl) and hodgkin's lymphoma using elisa and pcr on serum specimens. b19v nonstructural protein is known to alter the expression of cellular factors including interleukin-6 (il-6), which can increase the risk for and worsen the prognosis of lymphomas. | 2013 | 23522566 |
| high-efficiency transduction of primary human hematopoietic stem cells and erythroid lineage-restricted expression by optimized aav6 serotype vectors in vitro and in a murine xenograft model in vivo. | we have observed that of the 10 aav serotypes, aav6 is the most efficient in transducing primary human hematopoietic stem cells (hscs), and that the transduction efficiency can be further increased by specifically mutating single surface-exposed tyrosine (y) residues on aav6 capsids. in the present studies, we combined the two mutations to generate a tyrosine double-mutant (y705+731f) aav6 vector, with which >70% of cd34(+) cells could be transduced. with the long-term objective of developing re ... | 2013 | 23516552 |
| water, water, everywhere. acute parvovirus b19 infection. | | 2013 | 23472922 |
| human parvovirus b19 in solid organ transplantation. | | 2013 | 23465012 |
| transition from endocapillary proliferative glomerulonephritis to membranoproliferative glomerulonephritis in a patient with a prolonged human parvovirus b19 infection. | we report a case in which renal biopsies were performed 4 years apart in a woman with a prolonged human parvovirus b19 (hpb19) infection. when she was 29 years old the first biopsy, performed because of microscopic hematuria and mild proteinuria, showed endocapillary and mesangial proliferative glomerulonephritis in light microscopy as well as deposits of immunoglobulins (igs) and complement c3 on capillary walls. mesangial, intramembranous, and subepithelial hump-like electron dense deposits we ... | 2014 | 23442257 |
| long-term use of ventricular assist device as a bridge to recovery in acute fulminant myocarditis. | we report the successful long-term use of a left ventricular assist device (berlin excor) as a bridge to recovery in a patient with fulminant parvovirus b19 myocarditis. the use of this device allowed time for myocardial recovery, avoiding the need for cardiac transplantation. | 2013 | 23438564 |
| successful immunotherapy in life-threatening parvovirus b19 infection in a child. | we report a case of an immunocompetent child who developed parvovirus b19 infection complicated by autoinflammatory disease with myocarditis, tamponade and macrophage activation syndrome. he recovered with immunotherapy including prednisone, immunoglobulins, cyclosporin and anakinra (anti-interleukin-1). the report shows that parvovirus can provoke severe systemic inflammation with acute heart injury and that anti-interleukin-1 might be considered in such parvovirus-related inflammation. | 2013 | 23429554 |
| human parvovirus b19 infection in a renal transplant recipient: a case report. | parvovirus b19 presents tropism for human erythroid progenitor cells, causing chronic anemia in organ transplant recipients, due to their suppressed humoral and cellular responses. diagnosis may be achieved through serological tests for detection of anti-b19 antibodies. however, renal transplant recipients are not routinely tested for parvovirus b19 infection, since there is scanty data or consensus on screening for b19 infection, as well as for treatment or preventive management of transplanted ... | 2013 | 23343210 |
| molecular and clinical evaluation of the acute human parvovirus b19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature. | human parvovirus b19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. the different clinical outcome of the acute parvovirus b19 infection in two pediatric patients with sickle cell disease has been examined. one of them developed life-threatening condition requiring emergency transfusions, while the other had asymptomatic infection, diagnosed occasionally. both cases had high viral load ... | 2013 | 23290473 |
| parvovirus b19–induced pure red cell aplasia in a heart transplant recipient. | | 2012 | 23256205 |
| prevalence of parvovirus b 19 infection in children with aplastic anemia. | we studied the prevalence of parvovirus b19 infection in pediatric patients with acquired aplastic anemia. detection of parvovirus b19 dna by pcr and igm antibodies by elisa was carried out in 66 pediatric patients with acquired aplastic anemia. 45 healthy children acted as controls. parvovirus b19 dna was detected in significantly higher number of patients in comparison to controls (27% vs 2%, p = 0.001). similarly, parvovirus b19 igm antibodies were detected in 17 (25.8%) patients as against o ... | 2013 | 23255678 |
| intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus b19 infection: a retrospective study of 10 patients and review of the literature. | we evaluated the efficacy of intravenous immunoglobulin (ivig) therapy in patients with pure red cell aplasia (prca) related to human parvovirus b19 (hpv-b19) infection. | 2013 | 23243178 |
| standard and etiology-directed evidence-based therapies in myocarditis: state of the art and future perspectives. | in inflammatory dilated cardiomyopathy and myocarditis, there is apart from heart failure and antiarrhythmic therapies no alternative to an etiologically driven specific treatment. their prerequisites are noninvasive and invasive biomarkers including endomyocardial biopsy and pcr on cardiotropic agents. this review deals with the different etiologies of myocarditis and inflammatory cardiomyopathy including the genetic background, the predisposition for heart failure and inflammation. it analyses ... | 2013 | 23225133 |
| [observations on human parvovirus b19 infection diagnosed in 2011]. | the incidence of human parvovirus b19 infection is unknown. | 2012 | 23204301 |
| a study on the association between parvovirus b19 infection, serum tumour necrosis factor and c-reactive protein levels among nigerian patients with sickle cell anaemia. | microbial burden involving parvovirus b19 infection has been recognised as a major cause of morbidity and mortality in sickle cell anaemia (sca) patients. given the recent reports of parvovirus b19 infection in nigeria and the role of inflammation in sickle cell crisis, knowledge of the relationship between the two may be essential for deploying appropriate interventions in infected patients. this study determined the serum levels of tumour necrosis factor alpha (tnf-α) and c-reactive protein (c ... | 2012 | 23192499 |
| portable chemiluminescence multiplex biosensor for quantitative detection of three b19 dna genotypes. | a miniaturized multiplex biosensor exploiting a microfluidic oligonucleotide array and chemiluminescence (cl) lensless imaging detection has been developed for parvovirus b19 genotyping. the portable device consists of a reaction chip, comprising a glass slide arrayed with three b19 genotype-specific probes and coupled with a polydimethylsiloxane microfluidic layer, and a charge-coupled device camera modified for lensless cl imaging. immobilized probes were used in dna hybridization reactions wi ... | 2013 | 23187829 |
| detection of human parvovirus b19 in cancer patients using elisa and real-time pcr. | parvovirus b19 (b19) is associated with a wide range of diseases in humans, whose severity depends on the immunological and haematological status of the host. | 2012 | 23183464 |
| neurologic consequence of a parvovirus b19 infection. | | 2013 | 23182456 |
| investigation of human parvovirus b19 occurrence and genetic variability in different leukaemia entities. | human parvovirus b19v (b19v) has been associated with various haematological disorders, but data on its prevalence in leukaemia are scarce. in this cross-sectional study, we investigated patients in sao paulo, brazil with leukaemia to determine the molecular frequency of b19 variants and characterize the viral genetic variability by partial and complete sequencing of the coding of non-structural protein 1 (ns1)/viral capsid proteins 1 and 2 (vp1/vp2). the presence of b19v infections was investig ... | 2013 | 23167493 |
| impact of chemiluminescent enzyme immunoassay screening for human parvovirus b19 antigen in japanese blood donors. | to reduce the risk of human parvovirus b19 (b19v) transmission through contaminated blood for transfusion and plasma-derived products, the japanese red cross (jrc) blood centers introduced b19v antigen screening by chemiluminescent enzyme immunoassay (cleia-b19v) in 2008. | 2013 | 23145866 |
| severe bone marrow failure associated with human parvovirus b19 infection in a case with no underlying disorder. | | 2012 | 23143653 |
| common variable immunodeficiency presenting with persistent parvovirus b19 infection. | parvovirus b19 infection in healthy hosts is self-limited, but persistent infection has been described in patients with cellular immune defects. a 6-year-old boy presented with a 6-month history of weight loss and malaise and a 1-month history of fever and polyarticular arthritis. parvovirus dna was detected in plasma at 10 300 copies/ml. levels of immunoglobulin (ig)g, iga, igm, igg-1, and igg-2 were low, and antibody responses to vaccine antigens were impaired. hiv antibody and dna polymerase ... | 2012 | 23129076 |
| the effects of the 11 kda protein and the putative x protein on the p6 promoter activity of parvovirus b19 in hela cells. | human parvovirus b19 (b19) is a small nonenveloped icosahedral virus with a single-stranded, linear 5.6 kb dna genome. the p6 promoter, at map unit 6 of the viral genome, controls the expression of all b19 transcripts. some previous reports revealed that this promoter is transactivated by ns1 protein. in an attempt to investigate the roles of other small viral proteins in the control of the p6 promoter activity, various truncated promoter/reporter constructs along with these nonstructural protei ... | 2013 | 23114653 |
| [a neonate with subumbilical swellings]. | a neonate presented with hypoplasia of the abdominal wall muscles after fetal ascites due to anemia caused by an intra-uterine infection with parvovirus b19. because this is an extremely rare complication, pathogenesis and prognosis are currently unclear. | 2012 | 23114168 |
| sweet's syndrome and acute parvovirus b19 infection. | | 2013 | 23113722 |
| human parvovirus b19-induced acute glomerulonephritis: a case report. | human parvovirus b19 (hpv b19) infection is well known as a cause of erythema infectiosum in children. acute glomerulonephritis due to hpvb19 infection is rarely observed in adults. here, we present the case of a 45-year-old female who showed acute glomerulonephritis induced by hpvb19 infection with various autoantibodies. she had proteinuria (175 mg/g creatinine) and hematuria (20-29 erythrocytes per high-power field) in a urinalysis, and various autoantibodies such as antinuclear antibodies, p ... | 2013 | 23113616 |
| anterior ischemic optic neuropathy in patient with hereditary spherocytosis and coexisting angioid streaks. | purpose. to describe a rare case of hereditary spherocytosis (he) with angioid streaks that developed anterior ischemic optic neuropathy (aion).
method. case report.
results. a 53-year-old woman with he had a 3-day history of blurred vision in the lower hemifield in the left eye. at presentation, her visual acuity was 20/20 od and 20/200 os. perimetric testing showed a relative scotoma in the superior parafoveal region in the right eye and an inferior altitudinal field defect in the left eye. fu ... | 2012 | 23112036 |
| [posttransplant chronic anemia: parvovirus b19]. | anemia is frequent in kidney transplant patients, and its prevalence varies according to posttransplant time and the adopted diagnostic criteria. parvovirus b19 (pv b19) infection is an underdiagnosed cause of anemia in this particular population. to illustrate epidemiologic and clinical data regarding it, we present a case of pv b19 infection complicated by pure red cell aplasia (prca), pointing out the pitfalls we encountered in diagnosis and treatment. the use of viral dna detection by polyme ... | 2012 | 23099839 |
| pure red cell aplasia in a simultaneous pancreas-kidney transplantation patient: inside the erythroblast. | a case of pure red cell aplasia in a simultaneous kidney-pancreas transplant recipient on immunosuppressive therapy is reported here. the patient presented with anemia unresponsive to erythropoietin treatment. bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus b19 dna in peripheral blood. after the administration of intravenous immunoglobulin the anemia improved with a risin ... | 2012 | 23087806 |
| parvovirus b19 infection in the first trimester of pregnancy and risk of fetal loss: a population-based case-control study. | because parvovirus b19 infection during pregnancy has been associated with increased risk of fetal loss in small or selected study populations, the authors evaluated the risk in a population-based study. a nested case-control study was conducted by using a population-based screening for syphilis in 3 regions in denmark from 1992 to 1994. cases of women with fetal loss were identified in the national patient register (n = 2,918), and control women with live-born children were identified in the me ... | 2012 | 23051601 |
| case for diagnosis. papular-purpuric gloves and socks syndrome. | papular-purpuric gloves and socks syndrome is a rare, highly contagious dermatosis caused by parvovirus b19, which may result in the abrupt cessation of red blood cell production in patients with preexisting hematological diseases. it affects predominantly children and young adults and has an unusual presentation. | 2012 | 23044582 |
| mirror syndrome in a chinese hospital: diverse causes and maternal fetal features. | to investigate the clinical characteristics of mirror syndrome. | 2013 | 23035798 |
| evidence for the transmission of parvovirus b19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening. | parvovirus b19 (b19v) is a small, nonenveloped virus that typically causes a benign flu-like illness that occurs most frequently in childhood. the virus is resistant to current viral inactivation steps used in the manufacture of antihemophilic factor concentrates and b19v transmission through these products has been documented. since 2000, b19v nucleic acid test (nat) screening of plasma pools has been implemented to further decrease the viral burden in these products, but no study has examined ... | 2013 | 22998193 |
| [predictive factors for fetal tolerance to cordocentesis: a monocentric retrospective study]. | indications for fetal blood sampling (fbs) are getting more limited. in this context, we aimed to evaluate fetal loss and morbidity associated with fbs and to precise the predictive parameters for fetal complications. more than a retrospective evaluation of our practices, the final end point of our study was to better inform the patients coming to our centre. | 2012 | 22981975 |
| wells syndrome in a child triggered by parvovirus b19 infection? | | 2012 | 22980284 |
| the lack of routine surveillance of parvovirus b19 infection in pregnancy prevents an accurate understanding of this regular cause of fetal loss and the risks posed by occupational exposure. | in europe, fetal loss due to parvovirus b19 (b19v) is under-reported and a poorly addressed occupational risk to pregnant women. this is exemplified internationally, where it was unmentioned in the last two european centre for disease prevention and control (ecdc) annual surveillance reports or its 2009 special report on infections in pregnancy. to assess this potential for underestimating b19v fetal loss in pregnancy, we undertook a systematic review of practice in northern ireland in the manag ... | 2013 | 22977072 |
| capsid protein expression and adeno-associated virus like particles assembly in saccharomyces cerevisiae. | the budding yeast saccharomyces cerevisiae supports replication of many different rna or dna viruses (e.g. tombusviruses or papillomaviruses) and has provided means for up-scalable, cost- and time-effective production of various virus-like particles (e.g. human parvovirus b19 or rotavirus). we have recently demonstrated that s. cerevisiae can form single stranded dna aav2 genomes starting from a circular plasmid. in this work, we have investigated the possibility to assemble aav capsids in yeast ... | 2012 | 22966759 |
| development of chemiluminescent assays for the quantitative detection and imaging of 5-bromo-2'deoxyuridine-labeled dna in parvovirus b19-infected cells. | incorporation of exogenous analogues is a widely used method to evaluate dna synthesis in cultured cells exposed to exogenous factors such as infectious agents. herein, two new quantitative methodologies exploiting ultrasensitive chemiluminescence (cl) detection of 5-bromo-2'-deoxyuridine (brdu) have been developed: a cl microscope imaging assay to evaluate brdu labelling at single-cell level and a cl dot-blot assay to measure the amounts of dna produced in the course of an in vitro infection of ... | 2013 | 22960798 |
| [nonimmune hydrops fetalis: two decades of experience in a university hospital]. | to identify the etiology of nonimmune hydrops fetalis cases in pregnant women diagnosed and referred for prenatal care. | 2012 | 22948503 |
| how many times can parvovirus b19-related anemia recur in solid organ transplant recipients? | parvovirus b19 (pb19) infection is known to cause acute erythroblastopenia-mediated anemia in solid organ transplant (sot) recipients. intravenous immunoglobulins (ivig) and the decrease of immunosuppression level are supposed to induce a long-term remission, although no consensus exists about the dose and the schedule of ivig administrations. however, a few reports have shown that pb19-related anemia can recur despite this treatment, with a maximum of 3 recurrences reported. in this report, we ... | 2012 | 22931551 |
| molecular and phylogenetic analyses of human parvovirus b19 isolated from brazilian patients with sickle cell disease and β-thalassemia major and healthy blood donors. | human parvovirus b19 (b19v) is a recognized cause of life-threatening conditions among patients with hemoglobinopathies. this study investigates b19v infection in patients with sickle cell disease and β-thalassemia using different experimental approaches. a total of 183 individuals (144 with sickle cell disease and 39 with β-thalassemia major) and 100 healthy blood donors were examined for b19v using anti-b19v igg enzyme immunoassay, quantitative pcr, dna sequencing, and phylogenetic analysis. v ... | 2012 | 22930515 |
| atypical intrauterine parvo b19 infection. | human parvovirus b19 is a single-stranded dna virus. during pregnancy, parvovirus b19 infection can be asymptomatic or cause a variety of signs of fetal damage, fetal anemia, nonimmune hydrops fetalis, spontaneous abortion and can result in fetal death. recent improvements in diagnosing parvovirus infections and the availability of intrauterine transfusion have reduced the overall rate of fetal loss after maternal exposure. there is an approximately 30% risk of vertical transmission and 1% of hy ... | 2012 | 22926394 |
| global co-existence of two evolutionary lineages of parvovirus b19 1a, different in genome-wide synonymous positions. | parvovirus b19 (b19v) can cause infection in humans. to date, three genotypes of b19v, with subtypes, are known, of which genotype 1a is the most prevalent genotype in the western world. we sequenced the genome of b19v strains of 65 asymptomatic, recently infected dutch blood donors, to investigate the spatio-temporal distribution of b19v strains, in the years 2003-2009. the sequences were compared to b19v sequences from dutch patients with fifth disease, and to global b19v sequences as availabl ... | 2012 | 22912828 |
| mirna and tropism of human parvovirus b19. | parvovirus b19 has an extreme tropism for human erythroid progenitors. here we propose the hypothesis explaining the tropism of human parvovirus b19. our speculations are based on experimental results related to the capsid proteins vp1 and vp2. these proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mrnas were synthesized. our interpretation of these results is an inhibition of translation in nonpermissive cells by human mirnas. we bri ... | 2012 | 22902951 |
| acute glomerulonephritis in an immunocompetent elderly woman after contact with a child who had been diagnosed as erythema infectiosum. | the prevalence of postinfectious glomerulonephritis has decreased in most developed countries. we report the case of a previously healthy, immunocompetent 65-year-old woman who developed acute glomerulonephritis associated with human parvovirus b19 infection. she was referred by her primary care physician for suspected congestive heart failure but she had an elevated creatinine level and an abnormal urinalysis. renal biopsy showed diffuse endocapillary proliferative glomerulonephritis. after bio ... | 2012 | 22892503 |
| anemia as a complication of parvovirus b19 infection in renal transplant recipients. | the frequency of b19 infection in renal transplant donors and recipients was studied to determine the significance of active viral infection in the development of anemia. | 2012 | 22885363 |
| parvovirus b19 myocarditis causes significant morbidity and mortality in children. | although parvovirus b19 (pvb19) currently is the most common cause of viral myocarditis, limited pediatric data exist. whereas other viruses infect cardiomyocytes, pvb19 targets coronary endothelium, leading to myocardial ischemia and dysfunction. a retrospective review investigated patients with polymerase chain reaction (pcr)-verified pvb19 myocarditis at texas children's hospital and arkansas children's hospital (january 2005 to august 2008). the primary end points of the study were transplan ... | 2013 | 22872019 |
| mirna as activity markers in parvo b19 associated heart disease. | parvovirus b19 is a frequent virus detected in endomyocardial biopsies of patients with clinically suspected myocarditis or dilated cardiomyopathy (dcm). viruses often cause a more symptomatic disease with increased tissue injury if they become reactivated. a disease-specific differential expression of micrornas (mirnas) has been described in the regulation of replicating viruses. analyzing patients with latent and reactivated b19v infection, we found 29 differentially regulated mirnas and, in o ... | 2012 | 22872003 |
| human parvovirus b19 dna replication induces a dna damage response that is dispensable for cell cycle arrest at phase g2/m. | human parvovirus b19 (b19v) infection is highly restricted to human erythroid progenitor cells, in which it induces a dna damage response (ddr). the ddr signaling is mainly mediated by the atr (ataxia telangiectasia-mutated and rad3-related) pathway, which promotes replication of the viral genome; however, the exact mechanisms employed by b19v to take advantage of the ddr for virus replication remain unclear. in this study, we focused on the initiators of the ddr and the role of the ddr in cell ... | 2012 | 22837195 |
| proliferative glomerulonephritis with monoclonal immunoglobulin g3κ deposits in association with parvovirus b19 infection. | proliferative glomerulonephritis with monoclonal immunoglobulin g deposits is a recently described disease entity, characterized by nonorganized electron-dense deposits in glomeruli and immunofluorescence findings indicating monoclonal immunoglobulin g deposits. the pathogenesis of many cases of proliferative glomerulonephritis with monoclonal immunoglobulin g deposits remains unknown. we herein report 2 patients with parvovirus b19 infection who developed acute nephritic syndrome with hypocompl ... | 2012 | 22819999 |
| [parvovirus b19 infection in healthy adults]. | | 2012 | 22818220 |
| parvovirus b19 with a scarlatiniform/rubelliform rash and small joint arthritis mimicking rubella in an adult. | | 2012 | 22794938 |
| parvovirus b19 in pregnancy: possible consequences of vertical transmission. | the aim was to determine the outcome of pregnancies complicated by maternal parvovirus b19 (b19) infection. | 2012 | 22777688 |
| [an exceptional cause of acute hepatitis in an adult: parvovirus b19]. | there are multiple causes of hepatitis. the most frequent etiologies are viral, usually hepatitis a, b and c viruses. however, other, non-hepatotropic viruses can cause this disease, including parvovirus b19. we present a case of acute hepatitis due to parvovirus b19, as well as a review of the epidemiological, clinical, diagnostic and therapeutic features of this entity. | 2012 | 22749503 |
| [revision of the guideline 'blood transfusion': for the newborn]. | the large majority (> 90%) of very premature infants and newborn infants with haemolysis receive one or more red blood cell (rbc) transfusions. up to 35% of newborn infants have thrombocytopenia (platelet count < 150 x 109/l). following an unambiguous blood transfusion guideline leads to decrease in the number of transfusions given. the necessity for rbc transfusions can be diminished by use of diagnostic tests, micro-analysis techniques and delay of umbilical cord clamping (waiting for 30 secon ... | 2012 | 22748371 |
| characterization of the early steps of human parvovirus b19 infection. | the early steps of human parvovirus b19 (b19v) infection were investigated in ut7/epo cells. b19v and its receptor globoside (gb4cer) associate with lipid rafts, predominantly of the noncaveolar type. pharmacological disruption of the lipid rafts inhibited infection when the drug was added prior to virus attachment but not after virus uptake. b19v is internalized by clathrin-dependent endocytosis and spreads rapidly throughout the endocytic pathway, reaching the lysosomal compartment within minu ... | 2012 | 22718826 |
| occurrence of human bocaviruses and parvovirus 4 in solid tissues. | human bocaviruses 1-4 (hbov1-4) and parvovirus 4 (parv4) are recently discovered human parvoviruses. hbov1 is associated with respiratory infections of young children, while hbov2-4 are enteric viruses. the clinical manifestations of parv4 remain unknown. the objective of this study was to determine whether the dnas of hbov1-4 and parv4 persist in human tissues long after primary infection. biopsies of tonsillar tissue, skin, and synovia were examined for hbov1-4 dna and parv4 dna by pcr. serum ... | 2012 | 22711355 |
| [parvovirus b19 dna testing in polish blood donors, 2004-2010]. | since 2004 polish blood donors have been tested for parvovirus b19 (b19v) dna. the screening testing has been performed in donors of plasma for fractionation and anti-d and anti-hbs production and donors of erythrocytes used for immunization. aim is to present methods of the testing, quality control and results in period 2004-2010. | 2012 | 22708291 |
| [left ventricular assist device in a five-year-old child: a bridge to recovery in a case of viral myocarditis]. | viral myocarditis can lead to heart failure that is refractory to medication. in these cases, a ventricular assist device is a good therapeutic option that can be used as a bridge to transplantation or recovery. we describe the first case in portugal of recovery with ventricular assistance after severe myocarditis. | 2012 | 22704821 |
| differences in virus prevalence and load in the hearts of patients with idiopathic dilated cardiomyopathy with and without immune-mediated inflammatory diseases. | infections with cardiotrophic viruses and immune-mediated responses against the heart have been suggested to play a dominant role in the pathogenesis of idiopathic dilated cardiomyopathy (dcm). furthermore, immune-mediated inflammatory diseases (imids) may result in dcm. it has not previously been assessed whether dcm patients with and without an imid have different prevalences and quantities of cardiotrophic viruses in the heart. therefore, we compared the profiles of cardiotrophic viruses in h ... | 2012 | 22695157 |
| parvovirus b19 infection and severe anemia in renal transplant recipients. | kidney transplant (kt) recipients can develop symptomatic parvovirus (pv) b19 infections, frequently associated with persistent anemia. the aim of this study was to evaluate the prevalence and clinical significance of pv b19 infection in anemic and non-anemic kt patients. overall, out of 64 patients monitored for the presence of pv b19 by real-time pcr, 2 (3.12%) had an active pv b19 infection, in absence of other viral coinfections. the 2 cases occurred in nonanemic kidney transplant patients g ... | 2012 | 22619569 |
| complete remission of human parvovirus b19 associated symptoms by loxoprofen in patients with atopic predispositions. | two cases of women in their thirties with past histories of atopic dermatitis and allergic rhinitis developed a low grade fever, followed by a butterfly-shaped erythema, swelling of their fingers, and polyarthralgia. despite such symptoms that overlap with those of systemic lupus erythematosus (sle), the diagnostic criteria for sle were not fulfilled. due to positive results for human parvovirus b19 (hpv-b19) igm antibodies in the serum, diagnoses of hpv-b19 infection were made in both cases. al ... | 2012 | 22611409 |
| human parvovirus b19 genotype 3 associated with chronic anemia after stem cell transplantation, missed by routine pcr testing. | | 2012 | 22608841 |
| other viral infections in solid organ transplantation. | viral infections are a major cause of morbidity and even mortality in solid organ transplant recipients. this article reviews key aspects of infections in solid organ transplant recipients from respiratory viruses, such as influenza, polyomavirus, erythrovirus b19 and measles. | 2012 | 22542038 |
| [fetal parvowirus b19 infection with hydrops fetalis, a case report]. | parvovirus b19 (b19v) infection during pregnancy is a cause of nonimmune hydrops. we report a case of hydrops fetalis with severe fetal anemia in the course of b19v infection in the third trimester of pregnancy. maternal and fetal parvovirus b19 infection was confirmed using quantitative real time pcr detection of viral dna. the affected fetus was treated with three intrauterine transfusions. the baby was delivered by caesarean section at 36 weeks. up until 6 months of age no abnormalities in th ... | 2012 | 22568361 |
| immune thrombocytopenic purpura due to mixed viral infections. | an 11-year-old boy presented with epistaxis, petechial hemorrhages, easy bruising, and purpuric rash. he was diagnosed to have immune thrombocytopenic purpura and evidence of concomitant parvovirus b19 and dengue viral infection. | 2013 | 22544695 |
| human parvovirus b19 surveillance in patients with rash and fever from belarus. | human parvovirus b19 (b19v) infection in immunocompetent patients usually has a mild clinical course, but during pregnancy it can cause serious and even fatal complications in the fetus. the most common clinical presentation of b19v infection is erythema infectiosum and in this case laboratory confirmation is required for differentiation from other exanthematous diseases. measles and rubella negative sera collected in belarus between 2005 and 2008 from 906 patients with a rash and fever were scr ... | 2012 | 22499021 |
| pityriasis lichenoides et varioliformis acuta with numerous cd30(+) cells: a variant mimicking lymphomatoid papulosis and other cutaneous lymphomas. a clinicopathologic, immunohistochemical, and molecular biological study of 13 cases. | pityriasis lichenoides comprises a clinicopathologic spectrum of cutaneous inflammatory disorders, with the 2 most common variants being pityriasis lichenoides et varioliformis acuta (pleva) and pityriasis lichenoides chronica. the aim of the study was to describe 13 cases of a unique pleva variant characterized in the conspicuous cd30 component and thus mimicking lymphomatoid papulosis (lyp), a condition currently classified in the spectrum of cd30 lymphoproliferative disorders. the cohort incl ... | 2012 | 22472952 |
| investigation of parvovirus b19 seroprevalence, endothelin-1 synthesis, and nitric oxide levels in the etiology of essential hypertension. | many studies have focused on the role of pathogen infection in hypertension (ht). it has been postulated that increased vascular tonus in ht is basically related to the imbalance between vasodilator, such as nitric oxide (no), and vasoconstrictor, such as endothelin-1 (et-1), substances secreted by endothelium. the aim of the present study was to investigate the seroprevalence of human parvovirus b19 (hpv b19) in the etiology of essential ht and the effect of hpv b19 on et-1 and no levels in thi ... | 2012 | 22468640 |
| brain ultrasound findings in neonates treated with intrauterine transfusion for fetal anaemia. | the main causes of severe fetal anaemia are red-cell allo-immunization, parvo b19 virus infection and feto-maternal haemorrhage. treatment consists of intrauterine transfusion (iut). neuro-imaging studies in surviving neonates treated with iut are scarce. | 2012 | 22445567 |
| [monitoring of implementation of international programs of poliomyelitis eradication and measles and rubella elimination in the republic of belarus]. | monitoring of implementation of international programs of poliomyelitis eradication, and measles and rubella elimination in the republic of belarus based on results of molecular-epidemiologic studies of 2009 - 2010. | 2012 | 22442967 |
| green fluorescent protein (gfp) color reporter gene visualizes parvovirus b19 non-structural segment 1 (ns1) transfected endothelial modification. | human parvovirus b19 (pvb19) has been associated with myocarditis putative due to endothelial infection. whether pvb19 infects endothelial cells and causes a modification of endothelial function and inflammation and, thus, disturbance of microcirculation has not been elucidated and could not be visualized so far. | 2012 | 22438961 |
| parvovirus b19 is a bystander in adult myocarditis. | the genomic dna of parvovirus b19, a small single-stranded dna virus of the genus erythrovirus, has been shown to persist in solid tissues of constitutionally healthy, immunocompetent individuals. despite these data, many case reports and series have linked the presence of parvovirus b19 genomic dna, detected through nucleic acid amplification testing, with myocarditis and cardiomyopathy. herein, we use multiple tools to better assess the relationship between parvovirus b19 and myocarditis and c ... | 2012 | 22425629 |
| acute cerebellitis and concurrent encephalitis associated with parvovirus b19 infection. | | 2012 | 22418658 |
| parvovirus b19 dna cpg dinucleotide methylation and epigenetic regulation of viral expression. | cpg dna methylation is one of the main epigenetic modifications playing a role in the control of gene expression. for dna viruses whose genome has the ability to integrate in the host genome or to maintain as a latent episome, a correlation has been found between the extent of dna methylation and viral quiescence. no information is available for parvovirus b19, a human pathogenic virus, which is capable of both lytic and persistent infections. within parvovirus b19 genome, the inverted terminal ... | 2012 | 22413013 |
| acute fulminant hepatic failure associated with parvovirus b19 infection in an immunocompetent adult. | | 2012 | 22395961 |
| intrauterine transfusion for parvovirus b19 infection: long-term neurodevelopmental outcome. | to evaluate long-term neurodevelopmental outcome of children treated with intrauterine transfusions for fetal anemia because of parvovirus b19 infection. | 2012 | 22381602 |
| papular-purpuric "gloves and socks" syndrome. | papular-purpuric "gloves and socks" syndrome (ppgss), is an acute dermatosis characterized by a papular-purpuric edematous rash in a distinct ''gloves and socks'' distribution often accompanied by fever, asthenia and lymphadenophaties. it is mainly caused by parvovirus b19 (b19v) but other viruses and drugs such as trimethoprim/sulfametaxol or chemotherapics may be involved. we describe a case of ppgss with a serologically proven b19v infection in a 42-year-old italian kindergarten teacher suffe ... | 2012 | 22370576 |