| deep brain stimulation hardware-related infections: a report of 12 cases and review of the literature. | in this monocentric study, the median delay between deep brain stimulation implantation and infection was 28 days (range, 8-820). infections limited to generator (n = 4) required partial hardware removal, whereas infections involving frontal or retroauricular sites (n = 7) required total removal. surgical samples yielded staphylococcus aureus (n = 6), staphylococcus epidermidis (n = 2), propionibacterium acnes, and micrococcus species. | 2011 | 21460317 |
| anti-inflammatory properties of a new undecyl-rhamnoside (aprc11) against p. acnes. | acne vulgaris is a skin disease affecting pilosebaceous glands in which propionibacterium acnes (p. acnes) induced inflammation plays a central role. in order to develop new therapies against the inflammatory events, we evaluated the modulating effect of a new undecyl-rhamnoside, aprc11, on different markers of the inflammation. for this purpose, normal human keratinocytes taken from five healthy donors were pre-incubated for 24 h with aprc11 or zinc gluconate (zn) which was used as reference mo ... | 2011 | 21461892 |
| infection after shoulder surgery. | infection after shoulder surgery is rare but potentially devastating. normal skin flora, including staphylococcus aureus, staphylococcus epidermidis, and propionibacterium acnes, are the most commonly isolated pathogens. perioperative measures to prevent infection are of paramount importance, and clinical acumen is necessary for diagnosis. superficial infections may be managed with local wound measures and antibiotics; deep infections require surgical débridement in combination with antibiotic t ... | 2011 | 21464214 |
| galvanic zinc-copper microparticles produce electrical stimulation that reduces the inflammatory and immune responses in skin. | the human body has its own innate electrical system that regulates the body's functions via communications among organs through the well-known neural system. while the effect of low-level electrical stimulation on wound repair has been reported, few studies have examined the effect of electric potential on non-wounded, intact skin. a galvanic couple comprised of elemental zinc and copper was used to determine the effects of low-level electrical stimulation on intact skin physiology using a derma ... | 2011 | 21465312 |
| isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne. | a clear-cut need exists for safe and effective alternatives to the use of isotretinoin in severe acne. lack of data regarding the specifics of isotretinoin's mechanism of action has hampered progress in this area. recently, the protein neutrophil gelatinase-associated lipocalin (ngal) has been identified as a mediator of the apoptotic effect of isotretinoin on sebocytes. | 2011 | 21466536 |
| propionibacterium acnes osteomyelitis occurring 23 years after craniotomy: case report and review of literature. | background and importance:: propionibacterium acnes is an uncommon pathogen in delayed surgical site infection, and its indolent course can complicate diagnosis and treatment. we report the longest delay between neurosurgery and p. acnes infection reported. clinical presentation:: asymptomatic postoperative p. acnes osteomyelitis and tumor recurrence occurring 23 years after initial craniotomy. initial presentation was of tumor recurrence only, without signs or symptoms of infection. calvarial o ... | 2011 | 21471838 |
| a case of brain abscess caused by propionibacterium acnes 13 months after neurosurgery and confirmed by 16s rrna gene sequencing. | propionibacterium acnes is a gram-positive anaerobic bacillus and a normal inhabitant of the skin. although it is often considered a contaminant of blood cultures, it can occasionally cause serious infections, including postoperative central nervous system infections. here, we report the case of a 70-yr-old man who developed a large cerebral abscess caused by p. acnes 13 months after neurosurgery. immediate gram staining of the pus from his brain revealed the presence of gram-positive coccobacil ... | 2011 | 21474989 |
| a microbial aetiology of acne-what is the evidence? | a microbial aetiology of acne has been suggested since the beginning of the last century. there is considerable evidence, circumstantial at best, which suggests that micro-organisms, particularly propionibacterium acnes, are important in the pathogenesis of acne vulgaris. however, it is still unclear whether propionibacterium acnes is actually a causal agent in the development of non-inflamed or inflamed acne lesions. based on a review of the microbiological data on normal and acne affected skin ... | 2011 | 21495996 |
| evaluation of the scanrdi(r) as a rapid alternative to the pharmacopoeial sterility test method: comparison of the limits of detection. | two sterility test methods, the scanrdi® rapid sterility test and the united states pharmacopeia/european pharmacopoeia/japanese pharmacopoeia (usp/ep/jp) compendial sterility test, were compared with respect to the limits of detection for the presence of viable microorganisms in aqueous solutions at low inoculation levels. the scanrdi® system employs a combination of direct fluorescent labeling techniques and solid-phase laser scanning cytometry to rapidly enumerate viable microorganisms from a ... | 2010 | 21502036 |
| characterization and genome sequencing of two propionibacterium acnes phages displaying pseudolysogeny. | abstract: | 2011 | 21504575 |
| a rare complication of nd-yag capsulotomy: propionibacterium acnes endopthalmitis. | abstract posterior capsular opacification, also known as after cataract develops in 33 % of patients after uneventful cataract surgery. nd-yag laser capsulotomy is the treatment of choice for pco and is routinely performed by the general ophthalmologist on an opd basis. endophthalmitis, although a rare complication after nd-yag laser capsulotomy, has been reported in the literature. we report a case of propionibacterium acnes endophthalmitis following laser capsulotomy and the possible mechanism ... | 2011 | 21505550 |
| late-developing infection following posterior fusion for adolescent idiopathic scoliosis. | this study is a retrospective case series review of patients with adolescent idiopathic scoliosis (ais) who were revised more than 1 year after the index procedure, due to a late-developing deep wound infection, to determine onset, bacteriology, possible influence of implant alloy (titanium vs. stainless-steel) and treatment outcome of patients. from a total of 540 patients who underwent posterior-only fusion for ais from 1993 through 2005 at our institution, 15 cases (2.77%) were revised due to ... | 2011 | 21505809 |
| a novel multilocus sequence typing scheme for the opportunistic pathogen propionibacterium acnes and characterisation of type i cell surface-associated antigens. | we have developed a novel multilocus sequence typing scheme (mlst) and database (http://pubmlst.org/pacnes/) for propionibacterium acnes based on the analysis of seven core housekeeping genes. the scheme, which was validated against previously described antibody, single locus and random amplification of polymorphic dna (rapd) typing methods, displayed excellent resolution and differentiated 123 isolates into 37 sequence types (st). an overall clonal population structure was detected with six ebu ... | 2011 | 21511767 |
| evaluation of decontamination process of heart valve and artery tissues in european homograft bank (ehb): a retrospective study of 1,055 cases. | to evaluate the efficiency of decontamination practice in european homograft bank (ehb), the data of the cardiovascular tissues received during recent 2 years were retrospectively analysed in this study. after initial assessment, the tissues were incubated in a 3-antibiotics' cocktail at 4°c for 20-48 h. the states of contamination were evaluated before and after incubation with the focus on the differences in donor type, tissue type, germ type and incubation time. amongst 1,055 eligible tissues ... | 2011 | 21512894 |
| validation of a microbial detection system for use with acd-a platelets with pas iii platelet additive solution. | background: the bact/alert microbial detection system (bta) is used for testing leukoreduced apheresis platelets (lr-ap) in plasma. platelet additive solutions (pass) such as intersol (pas iii) may be used to reduce the amount of plasma transfused in lr-ap. this study evaluated the performance of the two-bottle bta testing scheme in the recovery of seeded microorganisms from lr-ap in intersol-plasma compared to a reference plate culture method. study design and methods: hyperconcentrated, double ... | 2011 | 21517894 |
| an update on the role of the sebaceous gland in the pathogenesis of acne. | the pathogenesis of acne, a disease of the pilosebaceous follicle and one of the most common chronic skin disorders, is attributed to multiple factors such as increased sebum production, alteration of the quality of sebum lipids, inflammatory processes, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinisation and the proliferation of propionibacterium acnes within the follicle. in particular, the sebaceous gland plays an exquisite role in the ... | 2011 | 21519409 |
| propionibacterium acnes camp factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment. | in the progression of acne vulgaris, the disruption of follicular epithelia by an over-growth of propionibacterium acnes (p. acnes) permits the bacteria to spread and become in contact with various skin and immune cells. | 2011 | 21533261 |
| optimization of periprosthetic culture for the diagnosis of propionibacterium acnes prosthetic joint infection. | propionibacterium acnes is increasingly recognized as an important agent of prosthetic joint infection (pji). however, the optimum culture conditions for recovery of this organism from pji specimens have not been determined. by applying a prolonged 28-day culture incubation to all periprosthetic specimens received for bacterial culture from 198 revision arthroplasty procedures, we retrospectively determined that a 13-day culture incubation period is necessary for the recovery of p. acnes from pa ... | 2011 | 21543562 |
| follicular spicules associated with propionibacterium acnes in response to erythromycin. | | 2011 | 21544949 |
| new, relevant information and innovative interventions in the management of acne. | the recent innovative interventions in the acnes (acne vulgaris, acne rosacea and acne inversa) have not occurred in their management; rather the major changes are occurring in how the disorders and the individual lesions are seen to originate and develop. to finalize the optimal management of each of the acnes will ultimately require that every step in the aetiopathogenesis described and postulated here will need to be tested, validated, and then appropriately countered with environmental and l ... | 2011 | 21566550 |
| genome sequence of a novel species, propionibacterium humerusii. | as part of a larger project to sequence multiple clinical isolates of propionibacterium acnes, we have produced a draft genome sequence of a novel propionibacterium species that is closely related to, yet distinct (by sequence) from p. acnes. we tentatively name this new species propionibacterium humerusii. | 2011 | 21571999 |
| contained rupture of an inflammatory abdominal aortic aneurysm into the iliopsoas muscle : report of a case. | a 72-year-old man with a history of old myocardial infarction was admitted to our hospital for surgical treatment of a ruptured abdominal aortic aneurysm. his hemodynamics was stable. he had left lumbar pain on moving his left leg and constipation for ten days without abdominal pain and high fever. elevation of fat density around the aneurysm and ureter involvement were noted on the computed tomography. these characteristic image findings indicated inflammatory aortic aneurysm. during operation, ... | 2011 | 21597420 |
| microbiology specimens obtained at the time of surgical lung biopsy for interstitial lung disease: clinical yield and cost analysis. | objectives: in efforts to obtain complete results, current practice in surgical lung biopsy (lb) for interstitial lung disease (ild) recommends sending lung tissue samples for bacterial, mycobacterial, fungal, and viral cultures. this study assesses the value of this practice by evaluating the microbiology findings obtained from lb for ild and their associated costs. methods: a total of 296 consecutive patients (140 women, 156 men, median age=61 years) underwent lb for ild from 2002 to 2009. all ... | 2011 | 21601471 |
| propionibacterium acnes infection of the elbow. | | 2011 | 21602062 |
| acne analysis, grading and computational assessment methods: an overview. | introduction: this paper presents a comprehensive review of acne grading and measurement. acne is a chronic disorder of the pilosebaceous units, with excess sebum production, follicular epidermal hyperproliferation, inflammation and propionibacterium acnes activity. most patients are affected with acne vulgaris, which is the prevalent type of acne. acne vulgaris consists of comedones (whitehead and blackhead), papules, pustules, nodules and cysts. objectives: to review and identify the issues fo ... | 2011 | 21605170 |
| detection of nine microorganisms from the initial carious root lesions using a taqman-based real-time pcr. | oral diseases (2011) objective: the purpose of this study was to quantify nine selected cariogenic bacteria in plaque from sound root surfaces and initial carious root lesions using taqman pcr and to analyse a putative dependence on the kind of initial periodontal treatment. material and methods: fifty-four subjects with generalized chronic periodontitis were randomly allocated to one of the following initial periodontal therapies: full-mouth disinfection, full-mouth scaling and root planing o ... | 2011 | 21605286 |
| in-vivo effectiveness of adapalene 0.1%/benzoyl peroxide 2.5% gel on antibiotic-sensitive and resistant propionibacterium acnes. | background: a gel combination treatment containing a retinoid (adapalene 0.1%) and an antimicrobial (benzoyl peroxide 2.5%) has been shown to be an effective treatment for acne vulgaris, addressing three of the four pathogenic factors (hyperkeratinization, propionibacterium acnes proliferation, inflammation) without contributing to the incidence of propionibacterium acnes antibiotic resistance as neither the retinoid nor benzoyl peroxide creates selective pressure for resistance. objective: to e ... | 2011 | 21607190 |
| efficacy of preoperative home use of 2% chlorhexidine gluconate cloth before shoulder surgery. | hypothesis: deep infection after shoulder surgery is a rare but devastating problem. this study tested the hypothesis that the home application of a 2% chlorhexidine gluconate cloth before shoulder surgery would be more efficacious than a standard shower of soap and water at decreasing the preoperative cutaneous levels of pathogenic bacteria on the shoulder. materials and methods: this randomized, prospective study evaluated 100 consecutive patients undergoing shoulder surgery. patients were ran ... | 2011 | 21612945 |
| a descriptive study of bacterial load of full-thickness surgical wounds in dermatologic surgery. | background surgical site infections (ssis) after dermatologic surgery cause pain, prolong healing, result in unaesthetic complications, and lead to excessive use of antibiotics. the pathogenesis of wound infections is complex and is dependent on bacterial load and diversity, among several factors. objective to investigate bacterial dynamics at dermatosurgical sites at different time intervals and assess the correlation with postoperative outcomes and to examine different endo- and exogenous fact ... | 2011 | 21615603 |
| nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. | microbial components stimulate innate immunity via toll-like receptors (tlrs), nucleotide-binding oligomerization domain (nod)-like receptors (nlrs), and/or il-1. we recently reported that in mice, escherichia coli lipopolysaccharide (lps, tlr4-ligand) promotes allergic responses to nickel (ni) at both the sensitization and elicitation steps. here, we examined in mice the effects of administering other microbial or inflammatory materials at the ni-sensitization step. a mixture of 1mm nicl(2) and ... | 2011 | 21621645 |
| medical microbiology | the microorganisms discussed in this chapter are taxonomically unrelated. the human
infections they cause are rare except in the case of listeria and
propionibacterium acnes. some of these infections are fatal;
others tend to be self-limited. recognition depends largely on the proper use of
bacteriological methods, which is important not only to ensure appropriate therapy
but also to exclude other possible agents ... | 1996 | 21413274 |
| sterility of posterior elements of the spine in posterior correction surgery. | abstract: study design. prospective clinical series.objective. to investigate the sterility of the posterior elements of the spine during posterior correction surgery.summary of background data: bacterial growth in the operating field is considered one of the causes of surgical-site infection.methods: eighty consecutive patients (mean age 19.5 years) who underwent posterior correction surgery for spinal deformities were included in the study. during surgery, specimens for bacterial culture were ... | 2011 | 21629158 |
| pathogenesis of acne vulgaris: what's new, what's interesting and what may be clinically relevant. | acne vulgaris is the most common skin disorder seen in dermatology and primary care offices today with significant associated morbidity. the pathogenesis of acne is complex and multifactorial, and there continues to be an influx of new information to increase our understanding of this chronic disease. recent advances in acne pathogenesis will be discussed, including theories regarding the sequence of events in acne formation, the functions of p. acnes, tlr involvement and role of the sebaceous g ... | 2011 | 21637898 |
| deep wound infection following pediatric scoliosis surgery: incidence and analysis of risk factors. | deep wound infection after spinal surgery is a severe complication that often requires prolonged medical and surgical management. it can compromise the outcome of the deformity correction, especially in patients requiring surgical intervention with subsequent removal of implants. ascertaining the incidence and risk factors leading to infection may help to prevent this problem. | 2011 | 21658334 |
| chronic infective endarteritis due to propionibacterium acnes on aortic prosthetic graft. | | 2011 | 21794971 |
| cathelicidin-bf, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris. | cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. cathelicidin-bf has been purified from the snake venoms of bungarus fasciatus and it is the first identified cathelicidin antimicrobial peptide in reptiles. in this study, cathelicidin-bf was found exerting strong antibacterial activities against propionibacterium acnes. its minimal inhibitory concentration against two strains of p. acnes was 4.7 µg/ml. cathelicidin-bf also effec ... | 2011 | 21789223 |
| folliculitis et perifolliculitis capitis abscedens et suffodiens controlled with a combination therapy: systemic antibiosis (metronidazole plus clindamycin), dermatosurgical approach, and high-dose isotretinoin. | folliculitis et perifolliculitis capitis abscedens et suffodiens is a rare disease of unknown etiology. it is a suppurative process that involves the scalp, eventually resulting in extensive scarring and irreversible alopecia. the condition is also known as 'acne necrotica miliaris' or 'proprionibacterium' folliculitis. most often the disease affects men of african-american or african-caribbean descent between 20 and 40 years of age. the clinical picture is determined by fluctuating painful fist ... | 2011 | 21772598 |
| in vitro antibacterial activity of nb-003 against propionibacterium acnes. | nb-003 and nb-003 gel formulations are oil-in-water nanoemulsions designed for use in bacterial infections. in vitro susceptibility of propionibacterium acnes to nb-003 formulations and comparator drugs was evaluated. both nb-003 formulations were bactericidal against all p. acnes isolates, including those that were erythromycin-, clindamycin- and/or tetracycline-resistant. in the absence of sebum the mic(90)/mbc(90) values for nb-003, nb-003 gel, salicylic acid (sa), and benzoyl peroxide (bpo) ... | 2011 | 21746943 |
| [postoperative recurrence of subdural empyema]. | we present a case of recurrent subdural post-surgical empyema by proprionibacterium acnes after a first drained empyema in which no microbiological diagnosis was reached. p. acnes is a gram-positive anaerobic organism which is part of the saprophytic flora of the skin and others parts of the body. however, it can cause infections, as in the central nervous system, especially post-surgical infections in which can be the second more frequent organism after staphylococcus aureus. p. acnes grows slo ... | 2011 | 21743949 |
| cognitive deficits after systemic induction of inducible nitric oxide synthase: a randomised trial in rats. | background: nitric oxide acts as an important neurotransmitter as well as a sepsis mediator. during sepsis, high levels of nitric oxide, produced by the inducible form of the nitric oxide synthase (inos), may lead to disturbances concerning these conflicting roles and cause septic encephalopathy. to evaluate this theory, we aimed at first, to demonstrate cognitive dysfunction in a rat model based on systemic inos induction; second, to elucidate molecular mechanisms; and third, to prevent cogniti ... | 2011 | 21743335 |
| tyrosinase activity of greyia flanaganii (bolus) constituents. | hyper-pigmentation of the skin is a common problem that is prevalent in middle aged and elderly people. it is caused by over production of melanin. tyrosinase is known to be the key enzyme in melanin production. ethanolic extract of greyia flanaganii leaves showed significant (p<0.05) antityrosinase activity exhibiting the ic(50) of 32.62++g/ml. the total extract was further investigated for its toxicity and effect on melanin production by melanocytes cells, and showed significant inhibition (p< ... | 2011 | 21680165 |
| comparative genomics and transcriptomics of propionibacterium acnes. | the anaerobic gram-positive bacterium propionibacterium acnes is a human skin commensal that is occasionally associated with inflammatory diseases. recent work has indicated that evolutionary distinct lineages of p. acnes play etiologic roles in disease while others are associated with maintenance of skin homeostasis. to shed light on the molecular basis for differential strain properties, we carried out genomic and transcriptomic analysis of distinct p. acnes strains. we sequenced the genome of ... | 2011 | 21738717 |
| in vitro inactivation of endodontic pathogens with nd:yag and er:yag lasers. | both nd:yag and er:yag lasers have been suggested as root canal disinfection aids. the aim of this in vitro study is to compare both wavelengths in terms of irradiation dose required for microbial inactivation, to quantify these irradiation doses and to investigate the influence of certain (laser) parameters on the antimicrobial efficacy. agar plates containing a uniform layer of enterococcus faecalis, candida albicans or propionibacterium acnes were mounted perpendicularly underneath the laser ... | 2011 | 21691826 |
| clearance of propionibacterium acnes by kupffer cells is regulated by osteopontin through modulating the expression of p47phox. | osteopontin (opn) is a cytokine with multiple functions, including the regulation of innate immune response. however, the detailed function and mechanism of opn in host defense against invaded microorganisms remain unclear. in this report, we revealed that opn could affect the clearance of propionibacterium acnes in kupffer cells. in a murine model of p. acnes induced hepatic granuloma, opn-deficient mice or wild-type (wt) mice treated with anti-opn mab exhibited more hepatic granuloma formation ... | 2011 | 21737140 |
| complete genome sequence of propionibacterium acnes type ib strain 6609. | propionibacterium acnes is an anaerobic gram-positive bacterium that forms part of the normal human cutaneous microbiota and is thought to play a central role in acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit (i. kurokawa et al., exp. dermatol. 18:821-832, 2009). here we present the whole genome sequence of p. acnes type ib strain 6609, which was recovered from a skin sample from a woman with no recorded acne history and is thus considered a nonpathogenic strain (i. nagy ... | 2011 | 21705602 |
| The SAPHO syndrome--are microbes involved? | The syndrome of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) includes a rare group of chronic, relapsing, inflammatory osteoarticular disorders that is conventionally associated with manifestations in the skin. Diagnostic dilemmas can arise due to incomplete manifestations or confusion generated through mimicking of other conditions, such as osteomyelitis. The aetiology of this syndrome remains unclear, but probably involves genetic, immunological and infectious mechanisms. The ... | 2011 | 22100290 |
| primary total joint arthroplasty performed in operating rooms following cases of known infection. | no study has examined infection rates in "clean" cases following "dirty" cases. this study evaluated patients undergoing elective primary total joint arthroplasties performed in operating rooms following cases of known infection for development of postoperative infection. a retrospective review of all elective primary total joint arthroplasties performed over a 5-year period at our institution was conducted. patients who underwent primary total joint arthroplasties that followed cases of known i ... | 2011 | 21902154 |
| Facial nerve palsy caused by parotid gland abscess. | Objectives:We present the first report of methicillin-resistant Staphylococcus aureus and Propionibacterium acnes parotid abscesses complicated by facial nerve palsy. Facial nerve palsy secondary to parotid gland abscess is rare, with only eight previously reported cases.Method:Case reports and literature review concerning parotid abscess and facial nerve palsy presentation and management.Case reports:Within two months, two female patients presented with parotid gland abscess complicated by unil ... | 2011 | 22017803 |
| Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. | Glycolic acid chemical peeling is effective for treating comedones, and some clinical data show that it also improves inflammatory eruptions. The purpose of this study was to identify the mechanism of glycolic acid chemical peeling to improve inflammatory acne. To assess growth inhibitory and bactericidal effects of glycolic acid on Propionibacterium acnes in vitro, we used an agar diffusion method and a time-kill method. To reveal bactericidal effects in vivo, we established an agar-attached me ... | 2011 | 21950544 |
| [Drug sensitivity of causative agents in ocular infection of external adnexa and anterior segments--multicenter study of causative agents and drug sensitivity of ocular infection by the Japanese Association for Ocular Infection part II]. | To report the drug sensitivity of causative agents produced by ocular infection of external adnexa and anterior segments investigated by the nationwide survey conducted by Japanese Association for Ocular Infection between September, 2007 and August, 2008. | 2011 | 22073598 |
| antibacterial properties of a glycolipid-rich extract and active principle from nunavik collections of the macroalgae fucus evanescens c. agardh (fucaceae). | this study investigated the antibacterial activity of glycolipid-rich extracts of the brown macroalga fucus evanescens in cell culture. accessions were collected on the arctic coast of ungava bay, nunavik, quebec. the crude ethyl acetate extract of these accessions showed strong antibacterial activity (≥4 log(10) cfu) against hemophilus influenzae , legionella pneumophila , propionibacterium acnes (atcc and clinical isolate), and streptococcus pyogenes at 100 µg/ml. this algal extract inhibited ... | 2011 | 21859295 |
| Neolitsea aciculata essential oil inhibits drug-resistant skin pathogen growth and Propionibacterium acnes-induced inflammatory effects of human monocyte leukemia. | This study examined the chemical composition of Neolitsea aciculata essential oil (NAE) and its biological activities. NAE was obtained by hydro-distillation of N. aciculata leaves collected in Jeju Island and analyzed by gas chromatography equipped with a mass spectrometer detector. 1-Dodecen-3-yne (12.5%), calarene (11.5%) and elemol (9.5%) were identified as the major components of NAE. The antibacterial and anti-inflammatory activities of NAE against skin pathogens were examined to determine ... | 2011 | 21922933 |
| newer approaches in topical combination therapy for acne. | acne vulgaris is a common chronic inflammatory cutaneous disease involving the pilosebaceous unit. its pathophysiology is multifactorial and complex, including obstruction of the pilosebaceous unit due to increased sebum production, abnormal keratinization, proliferation of propionibacterium acnes (p. acnes), and inflammation. topical agents are the most commonly used therapy for acne. first generation topicals mainly consist of single agent retinoids, benzoyl peroxide (bpo) and antibacterials t ... | 2011 | 22089505 |
| The use of lymecycline and benzoyl peroxide for the treatment of progressive macular hypomelanosis: a prospective study. | Progressive macular hypomelanosis is a dermatosis of uncertain etiology. The participation of Propionibacterium acnes has been suggested in view of the response achieved following therapy with drugs that are active against this bacterium. This report describes a series of thirteen patients with progressive macular hypomelanosis who were treated with an association of lymecycline and benzoyl peroxide over a three-month period. Response to treatment was excellent and the positive results were main ... | 2011 | 21987158 |
| Progression of cerebrospinal fluid cell count and differential over a treatment course of shunt infection. | Object The physiological reaction of CSF white blood cells (WBCs) over the course of treating a shunt infection is undefined. The authors speculated that the CSF WBC count varies with different infecting organisms in peak level and differential percentage of polymorphonuclear (PMN) leukocytes, lymphocytes, monocytes, and eosinophils. The authors hope to identify clinically useful trends in the progression of CSF WBCs by analyzing a large group of patients with successfully treated shunt infect ... | 2011 | 22132920 |
| topical dose justification: benzoyl peroxide concentrations. | abstract background: benzoyl peroxide (bpo) is widely utilized in acne treatment as an alternative to antibiotics against which propionibacterium acnes becomes more resistant. objective: this overview examines bpo dose justification. methods: pubmed, embase® and science citation index searches were conducted using the keywords "benzoyl peroxide" and "acne vulgaris". results: limited experimental data are available. however, there appears no significant difference in the efficacy of concentrat ... | 2011 | 22103743 |
| Corynebacterium pyruviciproducens promotes the production of ovalbumin specific antibody via stimulating dendritic cell differentiation and up-regulating Th2 biased immune response. | Corynebacterium pyruviciproducens (C. pyruviciproducens), a newly discovered Corynebacterium, is gram-positive, non-flagellate, non-spore-forming lipophilic rod. No known pathogenic components of Corynebacteria have been found in this new bacterium, such as diphtheria toxin and tuberculostearic acid. In the present study, referring to Propionibacterium acnes (P. acnes), a well-known bacterial adjuvant, the stimulation of dendritic cells by C. pyruviciproducens was analyzed through detecting the ... | 2011 | 22178104 |
| genome sequence of propionibacterium acnes type ii strain atcc 11828. | propionibacterium acnes is an anaerobic gram-positive bacterium that forms part of the normal human cutaneous microbiota and is occasionally associated with inflammatory diseases (i. kurokawa et al., exp. dermatol. 18:821-832, 2009). here we present the complete genome sequence for the commercially available p. acnes type ii reference strain atcc 11828 (i. nagy et al., microbes infect. 8:2195-2205, 2006) recovered from a subcutaneous abscess. | 2012 | 22156398 |
| delayed- versus acute-onset endophthalmitis after cataract surgery. | purpose: to report a large consecutive case series of patients who developed delayed-onset and acute-onset endophthalmitis after cataract surgery. design: retrospective consecutive case series. methods: the current study is a retrospective consecutive case series of patients treated between january 2000 and december 2009 for culture-proven endophthalmitis after cataract surgery. the study defined 2 groups after cataract surgery: acute-onset endophthalmitis (≤6 weeks after surgery) and delayed-on ... | 2011 | 22030353 |
| uv induced red fluorescence of the acne patients reflects regional casual sebum level and acne lesion distribution: qualitative and quantitative analyses of facial fluorescence. | background: the uv-induced red fluorescence of the acne patients had been considered to be caused by propionibacterium acnes. objectives: to study the correlation of the facial red fluorescence with the casual sebum level and the number of acne lesions and to investigate the difference in clinical features, according to both distribution and proportion of fluorescence. methods: a total of 878 patients, clinically diagnosed with acne vulgaris, were included. the inflammatory and non-inflammato ... | 2011 | 21895623 |
| first report of high levels of clindamycin-resistant propionibacterium acnes carrying erm(x) in japanese patients with acne vulgaris. | | 2011 | 22142418 |
| antibiotic-resistant propionibacterium acnes among acne patients in a regional skin centre in hong kong. | background there has been no study on antibiotic-resistant propionibacterium acnes in hong kong. objective we investigated the prevalence and pattern of antibiotic-resistant p. acnes and to identify any associated factors for harbouring the resistant strains. methods culture and sensitivity testing of p. acnes to commonly used antibiotics were performed. resistance to tetracycline was defined at a minimal inhibitory concentration (mic) of 2 μg/ml or more; erythromycin at an mic of 0.5 μg/ml o ... | 2011 | 22103749 |
| analysis of symptomatic and asymptomatic primary root canal infections in adult norwegian patients. | this molecular study analyzed the microbiota of primary root canal infections from adult norwegian patients. | 2011 | 21846535 |
| granulomatous propionibacterium acnes infection after trauma surgery. | we report here a rare case of infection caused by propionibacterium acnes following trauma surgery: a 36-year-old male, accident victim was admitted to the hospital because of polytrauma. he underwent a long-drawn-out surgical intervention and after a free-muscle transfer using the rectus femoris muscle, signs of inflammation were detected in the affected area. microbiological examination of the wound revealed the presence of p. acnes as the only etiological agent of this infection. adequate ant ... | 2011 | 21911069 |
| in vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, propionibacterium acnes. | this study was conducted to evaluate the antimicrobial activities of common seaweeds from the coast of south korea against the etiologic agents of acne vulgaris. fifty-seven species of seaweed were screened for potential antimicrobial activity. methanol extracts of 13 species (22.8%) showed inhibitory effects against propionibacterium acnes. the aqueous extracts of only two species (3.5%) showed antimicrobial activity. when tested with the agar disk diffusion method, ecklonia cava, e. kurome, is ... | 2011 | 22167943 |
| susceptibility of propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics. | the in vitro antimicrobial activity of ascorbic acid derivatives against propionibacterium acnes was tested either alone or in combination with a variety of antimicrobial agents, and their fractional inhibitory concentration index was determined using checkerboard tests. the antimicrobial effectiveness of zinc ascorbate in the treatment of acne vulgaris, either alone or in combination with antibiotics such as clindamycin that are commonly used in japan for the treatment of acne vulgaris, was the ... | 2011 | 22087070 |
| improvement of rna-sip by pyrosequencing to identify putative 4-n-nonylphenol degraders in activated sludge. | nonylphenols (np) have estrogenic potential because of their phenolic ring, but the organisms involved in the degradation of this alkylated phenol remain unidentified. using 16s ribosomal rna (rrna)-based stable isotope probing (sip) and a new method based on pyrosequencing, we identified the bacteria involved in the degradation of the aromatic ring of [u-ring-(13)c] 4-n-np in aerobic sludge. the first order degradation rate of 4-n-np was 5.5d(-1). single strand conformation polymorphism of dens ... | 2011 | 22154106 |
| Anti-in?ammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes. | Interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-a) from keratinocyte play important roles in initiating the inflammatory process of acne. They are used as major elements to evaluate the anti-inflammatory activity of drugs. In this study, various active constituents extracted from Chinese medicinal herbs were tested for their anti-inflammatory effects against P. acnes using ELISA. Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin ... | 2011 | 21999396 |
| Investigation of Propionibacterium acnes in progressive macular hypomelanosis using real-time PCR and culture. | Progressive macular hypomelanosis (PMH) is a dermatosis of unknown etiology. It has been concluded that it involves the presence of Propionibacterium acnes, a saprophyte of the pilosebaceous follicles. In our study, we investigated the presence of P. acnes in lesional and non-lesional skin of patients with PMH through quantitative real-time polymerase chain reaction (PCR) and bacterial culture from a skin fragment. | 2011 | 22004486 |
| the breast: a clean-contaminated surgical site. | capsular contracture is one of the most common complications associated with breast implants. while the cause of this process has not yet been elucidated, subclinical infection is a likely culprit. | 2011 | 21908811 |
| Acne vulgaris. | Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Although early colonisation with P acnes and family history might have important roles in the disease, exactly what triggers acne and how treatment affects the course of the disease remain unclear. Other factors such as diet have ... | 2011 | 21880356 |
| Acne vulgaris. | Acne vulgaris is one of the most common dermatological diseases, and caused by a combination of pathogenetic factors including follicular hyperkeratosis, seborrhea, colonization with Propionibacteriumacnes and inflammatory phenomena. Various medical treatments address these causative factors, but they are not always well tolerated. In the last decades, there has been increased interest in laser and light-based treatments. These optical devices mainly target Propionibacteriumacnes by activating p ... | 2011 | 21865806 |
| [a white woman with white skin spots]. | a 26-year-old white woman came to the clinic because of white spots. the spots were confluent in the midline, non-scaly and localized on trunk and proximal parts of the arms. biopsy showed loss of pigment in the epidermis. the diagnosis was: progressive macular hypomelanosis. | 2011 | 21854654 |
| validation of the bact/alert(®)3d automated culture system for the detection of microbial contamination of epithelial cell culture medium. | living tissue engineering for regenerative therapy cannot withstand the usual pharmacopoeia methods of purification and terminal sterilization. consequently, these products must be manufactured under aseptic conditions at microbiologically controlled environment facilities. this study was proposed to validate bact/alert(®)3d automated culture system for microbiological control of epithelial cell culture medium (eccm). suspensions of the nine microorganisms recommended by the european pharmacopoe ... | 2011 | 22160810 |
| [determination of causative agents in ocular infection of external adnexa and anterior segments--multicenter study of causative agents and drug sensitivity of ocular infection by the japanese association for ocular infection part i]. | to determine the causative agents of ocular infection of external adnexa and anterior segments due to selected criteria. | 2011 | 22073597 |
| Periprosthetic infections after shoulder hemiarthroplasty. | BACKGROUND: To examine the rates and predictors of deep periprosthetic infections after shoulder hemiarthroplasty. METHODS: We used prospectively collected institutional registry data on all primary shoulder hemiarthroplasty patients from 1976-2008. We estimated survival free of deep periprosthetic infections using Kaplan-Meier survival curves. Using univariate Cox regression analyses, we examined the association of patient-related factors (age, sex, body mass index), comorbidity (Deyo-Charlson ... | 2011 | 22154310 |
| efficiency of diversion of the first aliquot of blood and prestorage leukoreduction for preventing bacterial contamination in red blood cell concentrates assessed using a rapid polymerase chain reaction-based bacterial detection system. | sepsis caused by the bacterial contamination of blood products is a major infection risk associated with blood transfusion. diversion of the initial 25 ml of blood and prestorage leukoreduction were implemented in japan in 2007 for all donated blood products. we assessed the efficacy of these new collection procedures in preventing bacterial contamination of red blood cell (rbc) concentrates. | 2011 | 22191101 |
| single nucleotide polymorphisms of toll-like receptor-4 protect against acne conglobata. | background former studies have shown that propionibacterium acnes may stimulate expression of toll-like receptor 4 (tlr4) in keratinocytes of patients with acne vulgaris. objective to investigate the impact of single nucleotide polumorphisms (snps) of the tlr4 gene in acne vulgaris. methods genomic dna was isolated from 191 patients with acne vulgaris and 75 healthy controls. asp299gly and thr399ile snps were defined after cutting of the pcr products by restriction enzymes. sebum of lesions w ... | 2011 | 22085193 |
| molecular relatedness of propionibacterium species isolated from blood products and on the skin of blood donors. | in this study it was investigated whether propionibacterium acnes present in platelet concentrates (pcs) and related red blood cells (rbcs), originate from the skin of the donor. | 2011 | 21985045 |
| Heme Oxygenase-1 Alleviates Mouse Hepatic Failure through Suppression of Adaptive Immune Responses. | Heme oxygenase-1 (HO-1) has protective effects on liver damage induced by noxious stimuli. The mechanism of action of HO-1 is not well understood. In the present study, we investigate the effect of HO-1 in a model of fulminant hepatic failure induced by Propionibacterium acnes and lipopolysaccharide (LPS). The expression of HO-1 mRNA and protein in the liver was increased after repeated administration of the HO-1 inducer cobalt protoporphyrin IX. We found that HO-1 protected mice from acute live ... | 2012 | 21946119 |
| Diethylene glycol monoethyl ether: an emerging solvent in topical dermatology products. | Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Dermatologists are already treating patients that apply products containing 5-40% of this solvent multiple times each day. Aims To provide dermato ... | 2011 | 22151944 |
| Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. | Topical therapy with comedolytics and antibiotics are often advocated for mild and moderate severity acne vulgaris. Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. This randomized controlled assessor blind trial compared the clinical effectiveness and safety of eight weeks therapy of nadifloxacin 1% versus clindamycin 1% as add-on therapy to benzoyl peroxide (2.5%) in mild to moderate grade acn ... | 2011 | 22144763 |
| comparative photodynamic evaluation of new phenothiazinium derivatives against propionibacterium acnes(†). | the screening of recently patented derivatives of the standard phenothiazinium agents methylene blue and toluidine blue was carried out against propionibacterium acnes, the main bacterium associated with acne vulgaris. comparative tests were made using the topical agent benzoyl peroxide (bpo) and standard tetracyclines. each of the photosensitizers employed, including the lead compounds, was photobactericidal at lower concentrations than bpo, and produced a much more rapid kill than the tetracyc ... | 2011 | 22043962 |
| Propionibacterium acnes: infection beyond the skin. | Propionibacterium acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain. Device-related infections include those of joint prostheses, shunts and prosthetic heart valves. ... | 2011 | 22114965 |
| Multilocus Sequence Typing (MLST) and Phylogenetic Analysis of Propionibacterium acnes. | Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris and in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer. As the species includes evolutionary lineages with distinct association with health and disease, there is a need for a high-resolution typing scheme. Recently, two MLST schemes were reported, one based on ... | 2011 | 22205788 |
| molecular detection of in-vivo microbial contamination of metallic orthodontic brackets by checkerboard dna-dna hybridization. | knowing the microbiota that colonizes orthodontic appliances is important for planning strategies and implementing specific preventive measures during treatment. the purpose of this clinical trial was to evaluate in vivo the contamination of metallic orthodontic brackets with 40 dna probes for different bacterial species by using the checkerboard dna-dna hybridization (cddh) technique. | 2012 | 22196182 |
| intratumoral injection of propionibacterium acnes suppresses malignant melanoma by enhancing th1 immune responses. | malignant melanoma (mm) is an aggressive cutaneous malignancy associated with poor prognosis; many putatively therapeutic agents have been administered, but with mostly unsuccessful results. propionibacterium acnes (p. acnes) is an aerotolerant anaerobic gram-positive bacteria that causes acne and inflammation. after being engulfed and processed by phagocytes, p. acnes induces a strong th1-type cytokine immune response by producing cytokines such as il-12, ifn-γ and tnf-α. the characteristic th2 ... | 2011 | 22216160 |
| the role of rifampin against propionibacterium acnes biofilm in vitro and in an experimental foreign-body infection model. | propionibacterium acnes is an important cause of orthopedic implant-associated infections, for which the optimal treatment has not yet been determined. we investigated the activity of rifampin, alone and in combination, against planktonic and biofilm p. acnes in vitro and in a foreign-body infection model. the mic and the minimal bactericidal concentration (mbc) were 0.007 and 4 μg/ml for rifampin, 1 and 4 μg/ml for daptomycin, 1 and 8 μg/ml for vancomycin, 1 and 2 μg/ml for levofloxacin, 0.03 a ... | 2012 | 22252806 |
| reply: "follicular spicules associated with propionibacterium acnes with response to erythromycin": lack of evidence for the species? | | 2012 | 22225404 |
| blood collection procedures influence contamination rates in blood culture: a prospective study. | blood culture contamination is a significant adverse event. the aim of this project was to evaluate the efficacy of a strict blood collection procedure in reducing the blood culture contamination rate. | 2011 | 22340332 |
| the temporal dynamics of bacterial communities across human anterior nares. | the anterior nares (nostrils), are an important niche for bacterial colonization by both commensals and opportunistic pathogens. here the temporal dynamics and variation of the global nasal bacterial community across 25 healthy volunteers was evaluated over 15 months. overall, there was a global seasonal shift in bacterial community structure. such a temporal shift was also strongly evident in the abundances of species such as propionibacterium acnes and staphylococcus epidermidis. however, such ... | 2011 | 23757239 |
| prescribing prophylactic antibiotics to users of therapeutic contact lenses. | background: to describe the benefits and optimum use of prophylactic antibiotics in users of therapeutic contact lenses (tcl). methods: a microbiological study was carried out on samples from 33 patients who continuously wore tcl. the resistance to antibiotics of bacteria isolated in our health region was also reviewed. an assessment was also made on whether there were microorganisms of a higher pathogenic potential in tcl than conventional contact lenses, as reported in the literature. results: ... | 2012 | 23473085 |
| brain abscess induced by propionibacterium acnes in a patient with severe chronic sinusitis. | propionibacterium acnes has long been considered a contaminant organism. however, recently the isolation of this emerging pathogen has become a more difficult clinical challenge. infections of the central nervous system caused by p. acnes have been strongly associated with neurosurgical procedures. we describe a patient with propionibacterium acnes cerebral abscess developed as consequence of a severe chronic sinus disease. | 2013 | 23912875 |
| is there any association between sarcoidosis and infectious agents?: a systematic review and meta-analysis. | during the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. with the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. | 2016 | 27894280 |
| presence of bacteria in failed anterior cruciate ligament reconstructions. | novel microbial detection technologies have revealed that chronic bacterial biofilms, which are recalcitrant to antibiotic treatment, are common in failed orthopedic procedures. | 2015 | 26339561 |
| the use of pcr/electrospray ionization-time-of-flight-mass spectrometry (pcr/esi-tof-ms) to detect bacterial and fungal colonization in healthy military service members. | the role of microbial colonization in disease is complex. novel molecular tools to detect colonization offer theoretical improvements over traditional methods. we evaluated pcr/electrospray ionization-time-of-flight-mass spectrometry (pcr/esi-tof-ms) as a screening tool to study colonization of healthy military service members. | 2016 | 27448413 |
| the novel aminomethylcycline omadacycline has high specificity for the primary tetracycline-binding site on the bacterial ribosome. | omadacycline is an aminomethylcycline antibiotic with potent activity against many gram-positive and gram-negative pathogens, including strains carrying the major efflux and ribosome protection resistance determinants. this makes it a promising candidate for therapy of severe infectious diseases. omadacycline inhibits bacterial protein biosynthesis and competes with tetracycline for binding to the ribosome. its interactions with the 70s ribosome were, therefore, analyzed in great detail and comp ... | 2016 | 27669321 |
| propionibacterium acnes prosthetic valve endocarditis with abscess formation: a case report. | endocarditis due to propionibacterium acnes is a rare disease. scant data on treatment of these infections is available and is based on case reports only. if the disease is complicated by abscess formation, surgical intervention combined with an antibiotic therapy might improve clinical outcome. in some cases, cardiac surgeons are reluctant to perform surgery, since they consider the intervention as high risk. therefore, a conservative therapy is required, with little, if any evidence to choose ... | 2014 | 24568204 |
| chronic subdural hematoma infected by propionibacterium acnes: a case report. | we present a very rare case of a patient with an infected subdural hematoma due to propionibacterium acnes. a 63-year-old male complained of dizziness and was admitted to our hospital. he had a history of left chronic subdural hematoma due to a traffic accident, which had been conservatively treated. physical, neurological and laboratory examinations revealed no definite abnormality. plain ct scan demonstrated a hypodense crescentic fluid collection over the surface of the left cerebral hemisphe ... | 2015 | 25759659 |
| gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study. | elucidating gut microbiota among gallstone patients as well as the complex bacterial colonization of cholesterol gallstones may help in both the prediction and subsequent lowered risk of cholelithiasis. to this end, we studied the composition of bacterial communities of gut, bile, and gallstones from 29 gallstone patients as well as the gut of 38 normal individuals, examining and analyzing some 299, 217 bacterial 16s rrna gene sequences from 120 samples. | 2013 | 24083370 |