| sudden cardiac death from parvovirus b19 myocarditis in a young man with brugada syndrome. | cardiovascular diseases are the leading cause of sudden death all over the world. the aetiology of sudden cardiac death among young adults includes brugada syndrome and myocarditis. brugada syndrome is a genetic abnormality of sodium channels in the myocardium with a characteristic electrocardiographic pattern. myocarditis has several aetiologies including infections. one of the most common cardiotropic viruses is parvovirus b19. this infection presents as a febrile illness in childhood and may ... | 2014 | 24931854 |
| persistence of parvovirus b19 (b19v) dna and humoral immune response in b19v-infected blood donors. | parvovirus b19 (b19v) dna seems to persist in the plasma of b19v-infected blood donors. the relevance of this for recipients of single-donor blood components is yet unclear. | 2014 | 24916600 |
| parvovirus b19 genotype 2 in blood donations. | | 2014 | 24911910 |
| intrauterine blood transfusion: current indications and associated risks. | fetal anemia is a serious complication in pregnancy and associated with perinatal mortality and morbidity. during 25 years of worldwide experience with intravascular intrauterine blood transfusion, a variety of indications have been described. intrauterine transfusion (iut) treatment is considered most successful for fetal anemia due to red cell alloimmunization. moreover, the use of this procedure has also been reported in pregnancies with parvovirus b19 infection, fetomaternal hemorrhage and p ... | 2014 | 24903741 |
| parvovirus b19 vlp recognizes globoside in supported lipid bilayers. | studies have suggested that the glycosphingolipid globoside (gb4cer) is a receptor for human parvovirus b19. virus-like particles bind to gb4cer on thin-layer chromatograms, but a direct interaction between the virus and lipid membrane-associated gb4cer has been debated. here, we characterized the binding of parvovirus b19 vp1/vp2 virus-like particles to glycosphingolipids (i) on thin-layer chromatograms (tlcs) and (ii) incorporated into supported lipid bilayers (slbs) acting as cell-membrane mi ... | 2014 | 24889255 |
| clinical presentation and outcome of 20 fetuses with parvovirus b19 infection complicated by severe anemia and/or fetal hydrops. | the aim of this study was to assess the prognosis of parvovirus b19 infection with severely anemic and/or hydropic fetuses according to initial ultrasound and biological criteria. | 2014 | 24851784 |
| development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome. | cases 1 and 2 were 55- and 68-year-old males, respectively. both were administered deferasirox (dfx) because they received red blood cell transfusions regularly as treatment for myelodysplastic syndrome refractory anemia. dfx administrations were stopped on the 22nd day in case 1 and on the 78th day in case 2 because significantly reduced hemoglobin values and reticulocyte counts were observed. bone marrow examinations showed pure red cell aplasia in both cases. in case 1, the reticulocyte ratio ... | 2014 | 24850456 |
| clinical characteristics and genetic analysis of childhood acute lymphoblastic leukemia with hemophagocytic lymphohistiocytosis: a japanese retrospective study by the kyushu-yamaguchi children's cancer study group. | this present study sought to analyze acute lymphoblastic leukemia (all) patients with hemophagocytic lymphohistiocytosis (hlh) registered in kyushu-yamaguchi children's cancer study group studies conducted between 1996 and 2007. four of 357 patients, including two of 318 patients with b cell precursor acute lymphoblastic leukemia (bcp-all) and two of 39 of those with t cell acute lymphoblastic leukemia (t-all), were identified. hlh was observed more frequently in the t-all patients than in the b ... | 2014 | 24827398 |
| congenital human parvovirus b19 infection with persistent viremia. | | 2015 | 24807977 |
| antibody-mediated enhancement of parvovirus b19 uptake into endothelial cells mediated by a receptor for complement factor c1q. | despite its strong host tropism for erythroid progenitor cells, human parvovirus b19 (b19v) can also infect a variety of additional cell types. acute and chronic inflammatory cardiomyopathies have been associated with a high prevalence of b19v dna in endothelial cells of the myocardium. to elucidate the mechanisms of b19v uptake into endothelium, we first analyzed the surface expression of the well-characterized primary b19v receptor p antigen and the putative coreceptors α5β1 integrins and ku80 ... | 2014 | 24807719 |
| the presence of enterovirus, adenovirus, and parvovirus b19 in myocardial tissue samples from autopsies: an evaluation of their frequencies in deceased individuals with myocarditis and in non-inflamed control hearts. | multiple viruses have been detected in cardiac tissue, but their role in causing myocarditis remains controversial. viral diagnostics are increasingly used in forensic medicine, but the interpretation of the results can sometimes be challenging. in this study, we examined the prevalence of adenovirus, enterovirus, and parvovirus b19 (pvb) in myocardial autopsy samples from myocarditis related deaths and in non-inflamed control hearts in an effort to clarify their significance as the causes of my ... | 2014 | 24781135 |
| persistence of human parvovirus b19 in tissues from adult individuals: a comparison with serostatus and its clinical utility. | human parvovirus b19 (pvb19) is linked to variety of diseases, including erythema infectiosum, transient aplastic crisis, fetal hydrops, cardiomyopathy and, recently, hepatitis and arthritis. persistence of pvb19 in asymptomatic individuals has been reported in skin, synovium, myocardium and bone marrow. a higher level of pvb19 dna has been observed in various tissues from cases of disease than in controls. simultaneously, equal detection of pvb19 dna has been shown in both cases and controls. t ... | 2014 | 24777824 |
| erythrovirus b19 and autoimmune thyroid diseases. review of the literature and pathophysiological hypotheses. | erythrovirus b19 (evb19) has been incriminated, over recent years, in the onset and/or pathogenesis of many diseases, especially autoimmune thyroid diseases. this review of the literature (published over the last 40 years using pubmed and science direct search engines) was designed to define the role of evb19, particularly in autoimmune thyroid diseases.two cases of subacute thyroiditis, one case of graves' disease (associated with type 1 diabetes and rheumatoid arthritis), and one case of hashi ... | 2015 | 24760746 |
| different patterns of skin manifestations associated with parvovirus b19 primary infection in adults. | skin involvement is reported during primary parvovirus b19 infection in adults. | 2014 | 24726401 |
| dynamics of graft function measured by dna-technology in a patient with severe aplastic anemia and repeated stem cell transplantation. | although bone marrow transplantation (bmt) from an hla identical sibling is considered as treatment of choice in pediatric patients with severe aplastic anemia (saa), a significant number of them experience graft failure (gf) after bmt. we report a case of an 8-year-old male patient with saa who presented with a complicated posttransplant course due to parvovirus b19 infection and gf. a subsequent attempt to support the graft by antithymocyte globulin (atg) and a peripheral stem cell boost resul ... | 2014 | 24715914 |
| frequent human parvovirus b19 dna occurrence and high seroprevalence in haemophilic patients from a non-metropolitan blood centre, brazil. | | 2014 | 24684574 |
| parvovirus b19 persistence in abnormal thyroid tissue of a mature cystic ovarian teratoma: a case report. | ovarian teratomas represent the most common neoplasm derived from germ cells and can contain mature ectodermal, mesodermal, and endodermal tissues. in rare cases, these teratomas can be composed predominantly or solely of thyroid tissue. these thyroid cells often function similarly to normal thyroid tissues. this laboratory and others have previously shown that parvovirus b19 (b19v) persists in primary and metastatic thyroid tissues. no reports exist on possible b19v persistence in thyroid tissu ... | 2014 | 24668251 |
| parvovirus b19 infections and blood counts in blood donors. | parvovirus b19 (b19v) is a transfusion-transmissible virus. to obtain data about the prevalence, incidence, the course of b19v infection in blood donors and whether b19v might impair their blood counts, samples from blood donors with b19v infection were investigated. | 2014 | 24659948 |
| estimating the risk of parvovirus b19 infection in blood donors and pregnant women in japan. | seroepidemiological study of parvovirus b19 has not taken place for some 20 years in japan. to estimate the risk of parvovirus b19 infection in japan among blood donors and pregnant women in this century, a seroepidemiological survey and statistical modeling of the force of infection were conducted. | 2014 | 24658180 |
| the seroprevalence of parvovirus b19 infection in pregnant women in sudan. | parvovirus b19 (b19v) infection during pregnancy may have serious consequences like fetal anaemia, hydrops fetalis, and fetal loss. since epidemiological data on b19v infection are generally lacking in sudan, the current study aimed to determine the seroprevalence of b19v in sudanese pregnant women. five hundred women, attending antenatal clinics in khartoum state between november 2008 and march 2009, were enrolled and screened for b19v igg and igm antibodies by enzyme immunoassays. the study re ... | 2015 | 24650427 |
| an unusual cause of cerebellar ataxia in an immunocompromised elderly patient. | parvovirus b19 is a single-stranded dna virus belonging to the family parvoviridae, genus erythrovirus. pvb19 infection is most common in the pediatric population, manifesting as erythema infectiosum. in patients with hemoglobinopathy, pvb19 infection is known to cause aplastic anemia. pvb19 infection rarely affects the nervous system - reported manifestations include seizures, encephalitis and meningoencephalitis. less common presentations include stroke, cerebellar ataxia, optic neuritis, brac ... | 2014 | 24635888 |
| human parvovirus b19-induced aplastic crisis in an adult patient with hereditary spherocytosis: a case report and review of the literature. | although there are several case reports of human parvovirus b19 infection in patients with hereditary spherocytosis, no systematic reviews of adult patients with hereditary spherocytosis with human parvovirus b19 infection have been published as clinical case reports. in this study, we report a case of aplastic crisis due to human parvovirus b19 infection in an adult patient with hereditary spherocytosis. | 2014 | 24618088 |
| exacerbation of microcytic anemia associated with cessation of anti-retroviral therapy in an hiv-1-infected patient with beta thalassemia. | we report a patient with japanese minor β thalassemia and hiv-1 infection. the patient showed prolonged anemia, which was originally attributed to chronic parvovirus b19 infection. twelve years later, the patient presented with exacerbation of microcytic anemia following cessation of anti-retroviral therapy; the exacerbation resolved when anti-retroviral therapy was resumed. sequencing of the β globin gene revealed heterozygosity for a four-nucleotides deletion at codon 41/42 and minor β thalass ... | 2014 | 24613601 |
| human parvovirus b19 in childhood acute lymphoblastic leukaemia in basrah. | to investigate the association of human parvovirus b19 infection with the onset of acute lymphoblastic leukaemia and its effect on tel-aml-1 fusion gene and the presence of mutant p53. | 2014 | 24605704 |
| [genotyping of parvovirus b19 isolates circulating in northwestern federal district of russia]. | genotyping and phylogenetic analysis of parvovirus b19 isolates isolated on the territories of northwestern federal district (nwfd) of russia. | 2014 | 24605673 |
| seroprevalence of human parvovirus b19 in healthy blood donors. | human parvovirus b19 is an emerging transfusion transmitted infection. although parvovirus b19 infection is connected with severe complications in some recipients, donor screening is not yet mandatory. to reduce the risk of contamination, plasma-pool screening and exclusion of highly viraemic donations are recommended. in this study the prevalence of parvovirus b19 in healthy blood donors was detected by elisa. | 2013 | 24600121 |
| a serious parvovirus b19 genotype 2 infection not detected in a commercial pcr assay. | | 2014 | 24589313 |
| awareness of and knowledge about mother-to-child infections in japanese pregnant women. | to reduce the incidence of infants with congenital infections, women should be aware of and know prevention measures against maternal infection with mother-to-child infections during pregnancy. our objective was to assess the awareness of and knowledge about mother-to-child infections in japanese pregnant women. a survey of 343 japanese pregnant women was completed. awareness of 13 pathogens capable of mother-to-child transmission was surveyed. knowledge about the transmission route, the most su ... | 2014 | 24588778 |
| a case of parvovirus b19-induced pure red cell aplasia in a child following heart transplant. | we describe a case of an 11-year-old boy who underwent orthotopic heart transplant for dilated cardiomyopathy. he developed a normocytic, normochromic anaemia with a low reticulocyte count 1 month after transplant. a bone marrow biopsy was performed, which showed a mildly hypocellular bone marrow with few red blood cell precursors with giant pro-erythroblasts indicative of a pure red cell aplasia. parvovirus b19 polymerase chain reaction in the blood was positive 2 months after transplant. intra ... | 2015 | 24555951 |
| varied clinical course of aplastic crisis in hereditary spherocytosis. | this study is the first to report a familial case involving differing clinical courses of aplastic crisis triggered by parvovirus b19 in two patients with hs, although similar eosin-5-maleimide-binding test and sodium dodecylsulfate-polyacrylamide gel electrophoresis results had been obtained for both. one patient had short-term mild symptoms, whereas the other patient developed severe anemia that required blood transfusion, experienced fever for 13 days, and did not have any rash. the severity ... | 2014 | 24548193 |
| parvovirus b19 (b19) and cytomegalovirus (cmv) infections and anti-erythropoietin (anti-epo) antibodies in patients on dialysis hyporesponsive to erythropoietin therapy. | approximately 10% of patients receiving recombinant human erythropoietin (rhuepo) do not respond to the treatment. we evaluated parvovirus b19 (b19) and cytomegalovirus (cmv) infections and antierythropoietin (anti-epo) antibodies as potential causes of anemia in dialyzed patients, hyporesponsive to rhuepo. | 2014 | 24513539 |
| [an adult case of acute pericarditis and glomerulonephritis associated with human parvovirus b19 infection]. | we report herein on a 52-year-old japanese woman with acute pericarditis and glomerulonephritis associated with human parvovirus b19 infection, who had no significant medical history. the patient was admitted for progressive edema and upper abdominal pain. on physical examination, she had hypertension, generalized edema and upper abdominal tenderness. urinalysis revealed protein (1+), and occult blood (+/-), with cellular casts. echocardiography revealed pericardial effusion measuring 3-9mm in d ... | 2013 | 24483023 |
| [parvovirus b19 disease in immunocompetent adults. description of an outbreak in a urban healthcare center in zaragoza (spain)]. | | 2014 | 24480292 |
| bone marrow necrosis and fat embolism syndrome in sickle cell disease: increased susceptibility of patients with non-ss genotypes and a possible association with human parvovirus b19 infection. | fat embolism syndrome (fes) due to extensive bone marrow necrosis (bmn) in sickle cell disease (scd) is a potentially under-diagnosed complication associated with severe morbidity and mortality. we identified 58 cases reported in the world literature to date. typically, patients presented with a seemingly uncomplicated vaso-occlusive crisis (voc) and subsequently deteriorated rapidly with a drop in their haemoglobin and platelets, development of respiratory failure, encephalopathy and varying de ... | 2014 | 24468004 |
| epidemiological and clinical features of erythema infectiosum in children in novi sad from 2000 to 2009. | erythema infectiosum (ei) is a common childhood illness, caused by human parvovirus b19. it occurs sporadically or in epidemics and is characterized by mild constitutional symptoms and a blotchy or maculopapular lacy rash on the cheeks (slapped-cheek) spreading primarily to the extremities and trunk. the aim of our study was to analyse the epidemiological and clinical characteristics of erythema infectiosum in children. | 2013 | 24450250 |
| t-lineage acute lymphoblastic leukemia and parvovirus infection in a child with neurofibromastosis-1. | neurofibromatosis (nf-1) patients have an increased risk of developing malignancies most commonly rhabdomyosarcomas, optic gliomas, brain tumors and non-lymphocytic leukemias. acute lymphoblastic leukemia (all) has been infrequently reported in association with nf-1. we describe a rare association of nf-1, t-lineage all and parvovirus infection in a 12-year-old child. in addition, it is also to emphasize that a high index of suspicion should be kept for parvovirus b19 infection as a cause of bic ... | 2014 | 24441245 |
| the seroprevalence of parvovirus b19 among kidney transplant recipients: a single-center study. | parvovirus b19 is a dna virus that is responsible for causing several diseases in humans. parvovirus b19-induced persistent anemia is one of its manifestations that is relatively common in transplant recipients. this study was aimed to investigate the seroprevalence of parvovirus b19 among kidney transplant recipients. ninety-one transplant recipients were selected randomly and were investigated for several variables including age, gender, educational status, history of hemodialysis (hd), histor ... | 2014 | 24434377 |
| [the course of parvovirus b19 infection during pregnancy after kidney transplantation]. | having a tropism for erythroid progenitor cells, parvovirus b19 may cause partial red cell aplasia and thrombocytopenia. early diagnosis of parvovirus b19 infection in immunocompromised patients is needed for timely antiviral therapy. a high-risk group for parvovirus b19 infection includes patients with blood diseases who receive multiple transfusions of blood components; those who have undergone donor organ transplantation and are long taking immunosuppressive drugs; and pregnant women. these p ... | 2013 | 24432604 |
| paediatric dilated cardiomyopathy: clinical profile and outcome. the experience of a tertiary centre for paediatric cardiology. | dilated cardiomyopathy is the most common form of cardiomyopathy in the paediatric population and an important cause of heart transplantation in children. the clinical profile and course of dilated cardiomyopathy in children have been poorly characterised. a retrospective review of 61 patients (37 female; 24 male) diagnosed with dilated cardiomyopathy from january, 2005 to june, 2012 at a single institution was performed. the median age at diagnosis was 15 months. heart failure was present in 83 ... | 2015 | 24423967 |
| the human parvovirus b19 non-structural protein 1 n-terminal domain specifically binds to the origin of replication in the viral dna. | the non-structural protein 1 (ns1) of human parvovirus b19 plays a critical role in viral dna replication. previous studies identified the origin of replication in the viral dna, which contains four dna elements, namely nsbe1 to nsbe4, that are required for optimal viral replication (guan et al., 2009). here we have demonstrated in vitro that the ns1 n-terminal domain (ns1n) binds to the origin of replication in a sequence-specific, length-dependent manner that requires nsbe1 and nsbe2, while ns ... | 2014 | 24418564 |
| acute hepatitis and myositis associated with erythema infectiosum by parvovirus b19 in an adolescent. | erythema infectiosum is the most common clinical manifestation of parvovirus b19 infection although it has also been associated with rheumatologic diseases and various types of systemic vasculitides. acute hepatitis and benign myositis however are rarely reported in association with parvovirus b19 infection. | 2014 | 24410941 |
| identification of past and recent parvovirus b19 infection in immunocompetent individuals by quantitative pcr and enzyme immunoassays: a dual-laboratory study. | parvovirus b19 (b19v) is a member of the family parvoviridae, genus erythrovirus. b19v-specific igg and igm react differently against conformational and linear epitopes of vp1 and vp2 antigens, leading to the development of igg avidity and epitope type specificity (ets) enzyme immunoassays (eias) for distinguishing past from recent infection. additionally, b19v viral load determination (by quantitative pcr [qpcr]) is increasingly used in the staging of b19v infection. in this study, the utility ... | 2014 | 24403307 |
| myeloid leukemia of down syndrome: relation to parvovirus b19 infection and wilms tumor gene (wt1) expression. | | 2015 | 24390447 |
| hemolytic crisis as the initial presentation of hereditary spherocytosis induced by parvovirus b19 and herpes virus infection in a patient with the thalassemia trait: a case report. | | 2012 | 24385735 |
| measles, mumps, rubella, and human parvovirus b19 infections and neurologic disease. | while the systemic disorders associated with measles, mumps, and rubella viruses and human parvovirus b19 tend to be mild, each virus can produce potentially life-threatening neurologic disease in human hosts, especially when these viruses infect young children. two of the viruses, rubella and parvovirus b19, can be vertically transmitted to fetuses during maternal infection and cause congenital infection. neurologic complications are common after intrauterine infection with the rubella virus, a ... | 2014 | 24365423 |
| association of fetal loss with recent parvovirus infection and other demographic prognostic risk factors. | a total of 206 pregnant women were prospectively enrolled to this case-control study, from which 71 and 65 women had 1st and 2nd trimester miscarriage, respectively. the remaining 70 women with uneventful pregnancy were the control group. the serological profile of parvo b19 infection was confirmed with elisa. electron microscopy was selectively conducted in the patients' group. recent infection rate in women with 1st and 2nd trimester miscarriage was 3.68% and 5.8%, respectively. univariate ana ... | 2014 | 24359048 |
| acute herpes simplex virus 1 pneumonitis in a patient with systemic lupus erythematosus. | a woman with severe and longstanding systemic lupus erythematosus presented with a 1-week history of fever up to 38°c and pain in her right flank. computed tomography scan of the chest revealed interstitial infiltrates and multiple nodules. bronchoalveolar lavage did not show any inflammatory cells. gram stain and cultures for aerobic and anaerobic bacteria, fungi, and nocardia; acid-fast staining; polymerase chain reaction for tuberculosis, cytomegalovirus, herpesvirus 6, and parvovirus b19; an ... | 2014 | 24356475 |
| seroprevalence of parvovirus b19 igg and igm antibodies among pregnant women in oyo state, nigeria. | human parvovirus b19 causes a wide range of complications in pregnant women including abortion, severe fetal anemia, non-immune hydrops fetalis, and even intrauterine fetal death. however, there is a dearth of information on the prevalence of the virus among pregnant women in southwestern nigeria. | 2013 | 24334941 |
| [parvovirus b19 in adult: report of two cases]. | parvovirus b19 infection is asymptomatic in the majority of cases, but the are several well-known clinical manifestation. in adults transient aplastic crisis, chronic anemia, arthropathy, meningitis, encephalitis, myocarditis and acute hepatitis have been described. in this paper the authors report two cases - arthropathy and acute hepatitis - of parvovirus b19 infection in adults. | 2013 | 24326708 |
| parvovirus b19 at the culprit coronary stenosis predicts outcome after stenting. | parvovirus (pv) b19 dna is detected in endothelial cells and may cause endothelial dysfunction, which is involved in in-stent restenosis. we aimed at performing an exploratory analysis that evaluated if pvb19 dna at the culprit coronary stenosis would be associated with an increased rate of major adverse cardiac events (mace) after coronary stenting. | 2014 | 24289269 |
| [systemic inflammatory response syndrome and septic shock due to parvovirus b19 in a healthy child]. | | 2014 | 24280424 |
| infection and persistence of erythrovirus b19 in benign and cancerous thyroid tissues. | human erythrovirus b19 (evb19) is a small, pathogenic dna virus that has been associated with a wide range of illnesses. the primary site of replication is in bone marrow-derived erythroid progenitor cells, but evb19 dna has been detected in a wide range of organs. recently, studies have linked evb19 to thyroid cancers and other thyroid diseases. previous studies from multiple laboratories have detected evb19 capsid proteins in graves' disease, hashimoto's thyroiditis, and thyroid cancer tissues ... | 2014 | 24265024 |
| parvovirus b19 associated hepatitis. | parvovirus b19 infection can present with myriads of clinical diseases and syndromes; liver manifestations and hepatitis are examples of them. parvovirus b19 hepatitis associated aplastic anemia and its coinfection with other hepatotropic viruses are relatively underrecognized, and there is sufficient evidence in the literature suggesting that b19 infections can cause a spectrum of liver diseases from elevation of transaminases to acute hepatitis to fulminant liver failure and even chronic hepat ... | 2013 | 24232179 |
| novel b19-like parvovirus in the brain of a harbor seal. | using random pcr in combination with next-generation sequencing, a novel parvovirus was detected in the brain of a young harbor seal (phoca vitulina) with chronic non-suppurative meningo-encephalitis that was rehabilitated at the seal rehabilitation and research centre (srrc) in the netherlands. in addition, two novel viruses belonging to the family anelloviridae were detected in the lungs of this animal. phylogenetic analysis of the coding sequence of the novel parvovirus, tentatively called se ... | 2013 | 24223918 |
| use of belatacept as alternative immunosuppression in three renal transplant patients with de novo drug-induced thrombotic microangiopathy. | thrombotic microangiopathy (tma), a severe complication of renal transplantation, is a pathological process involving microvascular occlusion, thrombocytopenia, and microangiopathic hemolytic anemia. it generally appears within the first weeks after transplantation, when immunosuppressive drugs are used at high doses. de novo tma may also be drug-induced when calcineurin inhibitors or proliferation signal inhibitors are used. we report three cases of de novo drug-induced tma in renal transplant ... | 2013 | 24198835 |
| [regulatory effect of 11 kda protein of parvovirus b19 on nf-kappab pathway in hela cells]. | the 11 kda protein, a small nonstructural protein of parvovirus b19, may play important roles in viral replication cycle. to investigate the effect of 11 kda protein on the nf-kappab signaling pathway, we first prepared the poly-antiserum using gst-11 kda fusion protein purified via prokaryotic expression system, and demonstrated that the 11 kda protein mainly localized in cytoplasm when expressed in hela cells. meanwhile, luciferase activity assay and western blotting assay showed that 11 kda u ... | 2013 | 24195363 |
| pediatric parvovirus b19: spectrum of clinical manifestations. | parvovirus b19 (pvb19) infection has a varied spectrum of clinical manifestations, ranging from subclinical infection to skin and joint symptoms to hematologic effects with potential fatality. the most common manifestation of pvb19 infection in children is erythema infectiosum (ei). also known as fifth disease or slapped cheek syndrome, ei presents as an erythematous exanthem limited to the malar eminences that follows a mild prodromal illness. in healthy children, infection is selflimiting and ... | 2013 | 24195090 |
| increased incidence of acute parvovirus b19 infections in marseille, france, in 2012 compared with the 2002-2011 period. | human parvovirus b19 occurs worldwide and causes mild or asymptomatic disease in the form of cyclic local epidemics usually occurring in late winter and early summer. in 2012, a dramatic increase in cases was observed in the public hospitals system of marseille, with a total of 53 cases reported. here, we describe the characteristics of this outbreak and compare it with the local epidemiology of b19v infections observed during the 2002-2011 period. | 2014 | 24188076 |
| ballantyne syndrome and congenital anaemia associated with parvovirus b19 infection: case report and review. | acute maternal parvovirus b19 infection affects about 1% of all pregnancies worldwide. diaplacental transmission of parvovirus b19 during the second trimester can cause complications like foetal hydrops, premature delivery or foetal loss in about 20-30% of these pregnancies, whereas the majority of maternal infections remain clinically silent. in individual cases, foetoplacental hydrops (of various origins) can trigger a rare form of preeclampsia in the pregnant woman. the developing maternal oe ... | 2013 | 24170444 |
| haemophagocytic syndrome with a fatal outcome triggered by parvovirus b19 infection in the skin. | | 2014 | 24164247 |
| non-immune hydrops fetalis without anemia due to parvovirus b19. | | 2014 | 24140219 |
| persistent parvovirus b19 infection resulting in red cell aplasia after allogeneic hematopoietic stem cell transplantation. | persistent parvovirus b19 (pvb) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. however, the pathogenesis of persistent infection has yet to be fully elucidated. we report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (hsct) caused by pvb. the patient had already had pvb viremia before transpl ... | 2013 | 24134728 |
| single-cell chemiluminescence imaging of parvovirus b19 life cycle. | human parvovirus b19 (b19v) is a single-stranded dna virus. the genome encodes a multifunctional non-structural protein (ns), two capsid proteins (vp1, vp2) and other small non-structural proteins (7.5 kda, 9 kda, 11 kda). within sensitive cells, b19v can achieve a productive replicative cycle or, on the contrary, establish persistence; differences in its expression profile have been yet investigated following in vitro infections by methodologies enabling information on the entire infected cell ... | 2013 | 24100233 |
| cephalhematoma and petechial rashes associated with acute parvovirus b19 infection: a case report. | parvovirus b19 can cause petechial rashes in the acute phase of illness as well as erythema infectiosum (fifth disease) during convalescence. this petechial rash is often called "gloves and socks" syndrome because of the typical distribution of the eruption. however, involvement of other sites (e.g., intertriginous area) and generalized involvement have been recently recognized. we report here a patient with parvovirus-associated petechiae and cephalhematoma. | 2013 | 24093148 |
| human parvovirus b19 infection leads to downregulation of thyroid, estrogen, and retinoid hormone receptor expression. | erythrovirus b19 (b19v) is a member of the family parvoviridae. infection with b19v has been linked to a variety of diseases including erythroid, thyroid, neurological and autoimmune diseases. here we show that infection of primary cd36+ cells with b19v coincides with downregulation of thyroid, retinoid, and estrogen hormone receptors. in addition we show changes in expression of a variety of related downstream signaling genes participating in cancer and cardiac-related diseases in b19v-infected ... | 2013 | 24074579 |
| long-term parvovirus b19 infections with genetic drift after cord blood transplantation complicated by persistent cd4+ lymphocytopenia. | a 5-month-old girl was diagnosed with langerhans cell histiocytosis and received unrelated umbilical cord blood transplantation at the age of 14 months. after cord blood transplantation, cd4(+) lymphocytopenia from unknown causes was observed, and persistent infections with human parvovirus b19 (b19) occurred. we performed repeated longitudinal genetic analysis for b19, which revealed 6 nucleotide mutations in b19 nonstructural protein regions in the patient. the resulting changes of the nonstru ... | 2014 | 24072236 |
| parvovirus b19 uptake is a highly selective process controlled by vp1u, a novel determinant of viral tropism. | the vp1 unique region (vp1u) of human parvovirus b19 (b19v) is the immunodominant part of the viral capsid. originally inaccessible, the vp1u becomes exposed upon primary attachment to the globoside receptor. to study the function of the exposed vp1u in b19v uptake, we expressed this region as a recombinant protein. here, we report that purified recombinant vp1u binds and is internalized in ut7/epo cells. by means of truncations and specific antibodies, we identified the most n-terminal amino ac ... | 2013 | 24067971 |
| parvovirus b19 infection in pregnancy and subsequent morbidity and mortality in offspring. | because parvovirus b19 infection in pregnancy has been associated with infant morbidity and mortality in case reports and after intrauterine transfusion, we tested the population-based association using serum and hospital data of high quality. | 2013 | 24062296 |
| parvovirus b19 infection in pediatric patients with hematological disorders. | | 2013 | 24049371 |
| human parvovirus b19 infection causes cell cycle arrest of human erythroid progenitors at late s phase that favors viral dna replication. | human parvovirus b19 (b19v) infection has a unique tropism to human erythroid progenitor cells (epcs) in human bone marrow and the fetal liver. it has been reported that both b19v infection and expression of the large nonstructural protein ns1 arrested epcs at a cell cycle status with a 4 n dna content, which was previously claimed to be "g2/m arrest." however, a b19v mutant infectious dna (m20(mtad2)) replicated well in b19v-semipermissive ut7/epo-s1 cells but did not induce g2/m arrest (s. lou ... | 2013 | 24049177 |
| acute transverse myelitis associated with human parvovirus b19 infection. | we describe severe acute transverse myelitis in a previously healthy 9-year-old boy in whom primary human parvovirus b19 infection was confirmed serologically and b19 dna was detected in his serum and cerebrospinal fluid. besides erythema infectiosum, parvovirus b19 infection has various clinical manifestations; however, central nervous system involvement is rare. even more unusual is parvovirus b19-associated acute transverse myelitis. | 2014 | 24049056 |
| [detection of human parvovirus b19, human bocavirus and human parvovirus 4 infections in blood samples among 95 patients with liver disease in nanjing by nested pcr]. | to analyze the infection of human parvovirus b19, human bocavirus (hbov) and human parvovirus 4 (parv4) in blood samples among patients with liver disease in nanjing by molecular detection. | 2013 | 24044222 |
| studies on the inactivation of human parvovirus 4. | human parvovirus 4 (parv4) is a novel parvovirus, which like parvovirus b19 (b19v) can be a contaminant of plasma pools used to prepare plasma-derived medicinal products. inactivation studies of b19v have shown that it is more sensitive to virus inactivation strategies than animal parvoviruses. however, inactivation of parv4 has not yet been specifically addressed. | 2013 | 24032592 |
| keeping pace with parvovirus b19 genetic variability: a multiplex genotype-specific quantitative pcr assay. | three genotypes have been identified within the parvovirus b19 species (b19v), and such genetic diversity may have significant implications for the development of molecular detection assays. in the present study, b19v genetic variability has been examined on a subset of genomic sequences available in the ncbi nucleotide database, and a quantitative pcr (qpcr) assay able to detect, differentiate, and quantify all viral variants has been established. the designed primers and probes have been used ... | 2013 | 24006003 |
| cumulative amount of intravenous lipid intake and parenteral nutrition-associated cholestasis in neonates with gastrointestinal surgical disorders. | to evaluate if cumulative amount of intravenous lipid (il) intake is associated with severity of parenteral nutrition (pn)-associated cholestasis (pnac) in neonates with gastrointestinal surgical disorders (gisd). | 2014 | 24000109 |
| testicular cancer and viral infections: a systematic literature review and meta-analysis. | in 1984, newell and coworkers were the first to suggest that testicular cancer might have a viral etiology since it showed similar characteristics to hodgkin's lymphoma. a systematic literature review and meta-analysis was conducted to investigate a possible association between viral infections (ebv, cmv, parvovirus b19, hpv, and hiv) and testicular cancer. articles published from 1985 through june 2010 were located from medline and embase databases, 21 articles were finally included in the revi ... | 2013 | 23959966 |
| [immune thrombocytopenia as a complication of acute infectious diseases - case reports]. | immune thrombocytopenia (immune thrombocytopenic purpura, itp) is an acquired autoimmune disease, mediated by antibodies against platelet glycoproteins. itp can develop in the context of other disorders (secondary itp), including acute and chronic infections (hiv, h. pylori, hcv, hbv, cmv, ebv, vzv, parvovirus b19, rubella, etc.). the case reports present two children and one adult with itp complicating vzv, ebv and hav infections. corticosteroids are usually initial drugs, but they are controve ... | 2013 | 23945832 |
| co-infection of human parvovirus b19 with plasmodium falciparum contributes to malaria disease severity in gabonese patients. | high seroprevalence of parvovirus b19 (b19v) coinfection with plasmodium falciparum has been previously reported. however, the impact of b19v-infection on the clinical course of malaria is still elusive. in this study, we investigated the prevalence and clinical significance of b19v co-infection in gabonese children with malaria. | 2013 | 23945350 |
| human parvovirus b19 in pediatric and adult recipients of allogeneic hematopoietic stem cell transplantation. | | 2013 | 23933762 |
| recognizing and treating myocarditis in recent-onset systemic sclerosis heart disease: potential utility of immunosuppressive therapy in cardiac damage progression. | scleroderma heart disease is a major risk of death in systemic sclerosis (ssc). mechanisms underlying myocardial damage are still unclear. we performed an extensive study of ssc patients with recent-onset symptoms for heart disease and examined the efficacy of immunosuppressive therapy. | 2014 | 23932313 |
| anti-n-methyl-d-aspartate receptor encephalitis and parvovirus b19: a possible link? | | 2013 | 23919909 |
| low-level dnaemia of parvovirus b19 (genotypes 1-3) in adult transplant recipients is not associated with anaemia. | after acute parvovirus b19 (b19v) infection of immunocompetent individuals, viral genomes persist lifelong in various tissues. in immunocompromized patients, acute b19v infection may be associated with severe anaemia. it is unclear whether reactivation of latent b19v dna may contribute to persistent viraemia and anaemia in transplant recipients. | 2013 | 23916377 |
| parvovirus b19 associated acute hepatitis and hepatosplenomegaly. | | 2014 | 23886765 |
| seroprevalence of parvovirus b19 antibodies and evidence of viremia among nigerian patients with sickle cell anemia. | clinical, biochemical and molecular evidence for the sickle cell anemia (sca) crisis in nigerian patients arising from parvovirus b19 infection remains inadequate. this study determined the prevalence and correlates of anti-parvovirus b19 antibodies in a population of sca patients and non-sca healthy controls in lagos, nigeria. in this prospective cross-sectional study, we enrolled 73 confirmed sca patients from 5 district hospitals in lagos and 81 sex and age-matched non-sca healthy controls. s ... | 2013 | 23885266 |
| [papular-purpuric gloves and socks syndrome and thrombocytopenia related to parvovirus b19 infection]. | | 2014 | 23845252 |
| exacerbating effects of human parvovirus b19 ns1 on liver fibrosis in nzb/w f1 mice. | systemic lupus erythematosus (sle) is an autoimmune disorder with unknown etiology that impacts various organs including liver. recently, human parvovirus b19 (b19) is recognized to exacerbate sle. however, the effects of b19 on liver in sle are still unclear. herein we aimed to investigate the effects of b19 on liver in nzb/w f1 mice by injecting subcutaneously with pbs, recombinant b19 ns1, vp1u or vp2, respectively. our experimental results revealed that b19 ns1 protein significantly enhanced ... | 2013 | 23840852 |
| generation of a parvovirus b19 vaccine candidate. | parvovirus b19 is the causative agent of fifth disease in children, aplastic crisis in those with blood dyscrasias, and hydrops fetalis. previous parvovirus b19 virus-like-particle (vlp) vaccine candidates were produced by co-infection of insect cells with two baculoviruses, one expressing wild-type vp1 and the other expressing vp2. in humans, the vlps were immunogenic but reactogenic. we have developed new vlp-based parvovirus b19 vaccine candidates, produced by co-expressing vp2 and either wil ... | 2013 | 23827313 |
| recent parvovirus b19 infection in late pregnancy. | | 2013 | 23806249 |
| [reactivation of parvovirus b19 infection in an hiv-infected woman]. | infection by human parvovirus b19 (erythrovirus b19) is common and usually asymptomatic during childhood conferring lasting protection against a new infection. parvovirus b19 infection may cause erythema infectiosum (5th disease) and aplastic crisis. secondary symptomatic parvovirus b19 infection in the same patient is rare and its physiopathology is not always clear. | 2014 | 23791089 |
| [case report: a case of lupus-like presentation associated with human parvovirus b19 infection]. | | 2013 | 23777162 |
| human parvovirus b19 induced apoptotic bodies contain altered self-antigens that are phagocytosed by antigen presenting cells. | human parvovirus b19 (b19v) from the erythrovirus genus is known to be a pathogenic virus in humans. prevalence of b19v infection has been reported worldwide in all seasons, with a high incidence in the spring. b19v is responsible for erythema infectiosum (fifth disease) commonly seen in children. its other clinical presentations include arthralgia, arthritis, transient aplastic crisis, chronic anemia, congenital anemia, and hydrops fetalis. in addition, b19v infection has been reported to trigg ... | 2013 | 23776709 |
| a population-based epidemiological survey of human parvovirus b19 infection: a project of the kyushu and okinawa population study (kops). | human parvovirus b19 infection occurs by droplet nuclei through the respiratory tract and causes a wide range of diseases. it can be transmitted through blood transfusion from asymptomatic blood donors. this study was done to investigate the parvovirus b19 infection rate of a group of healthy japanese residents. of 2,081 blood samples tested, 15 (0.72 %) were positive for parvovirus b19 igm, 1,412 (67.9 %) for b19 virus igg, and 4 (0.2 %) for parvovirus b19 dna. about half of all women of childb ... | 2013 | 23775357 |
| [clinical and biological manifestations in primary parvovirus b19 infection in immunocompetent adult: a retrospective study of 26 cases]. | parvovirus b19 causes erythema infectiosum in children, transient aplastic anemia in patients with hemoglobinopathies, pur red cell aplasia in immunocompromised persons and hydrops fetalis in pregnancy. the spectrum of clinical and biological manifestations in immunocompetent adult continues to grow up. | 2014 | 23773900 |
| adenovirus vector-mediated rna interference for the inhibition of human parvovirus b19 replication. | human parvovirus b19 (b19v) has been considered to cause acute and chronic myocarditis, which is accompanied by endothelial dysfunction. currently, no causative treatment option for b19v-infections is available. since rna interference (rnai) has proven to be a highly potent antiviral approach, the aim of the current study was to develop an rnai-based strategy to inhibit b19v replication. three b19v-vp2-specific short hairpin rnas (shrnas) were designed and tested for their silencing activity in ... | 2013 | 23770153 |
| detection of erythrovirus b19 in thyroidectomy specimens from graves' disease patients: a case-control study. | environmental factors, such as viruses, are thought to contribute to the development of thyroid autoimmunity. erythrovirus b19 (evb19) is suspected to be involved in hashimoto's thyroiditis, but no direct evidence is available concerning the role of evb19 infection in graves' disease. the objective of this study was to investigate whether the presence of evb19 is more frequent in thyroidectomy specimens of patients undergoing thyroidectomy for graves' disease (cases) than for multinodular thyroi ... | 2013 | 23765778 |
| impaired genome encapsidation restricts the in vitro propagation of human parvovirus b19. | the lack of a permissive cell culture system hampers the study of human parvovirus b19 (b19v). ut7/epo is one of the few established cell lines that can be infected with b19v but generates none or few infectious progeny. recently, hypoxic conditions or the use of primary cd36+ erythroid progenitor cells (cd36+ epcs) have been shown to improve the infection. these novel approaches were evaluated in infection and transfection experiments. hypoxic conditions or the use of cd36+ epcs resulted in a s ... | 2013 | 23764418 |
| autoimmune hemolytic anemia with concurrent acute parvovirus b19 infection in a heterozygous for sickle cell patient and literature review. | | 2013 | 23758143 |
| prevalence of human parvovirus b19, bocavirus, and parv4 in blood samples from the general population of china and lack of a correlation between parvovirus and hepatitis b co-infection. | few comprehensive studies have investigated viraemia caused by human parvoviruses (hpavs) in china. a total of 1626 of blood samples were collected from non-hbv and hbv infected chinese subjects (adults, n = 1279; children, n = 347) from south-western and south-eastern china. dna from three hpavs was detected in blood samples using pcr-based assays. the epidemiological profiles and association with hbv co-infection were also analysed. of the 1626 blood samples tested, 138 (8.49%) were found to e ... | 2013 | 23737981 |
| clinical investigation of human parvovirus b19 infection after renal transplantation in china. | we investigated the incidence of human parvovirus b19 (hpv b19) infection after renal transplantation as well as the risk of anemia and renal allograft damage among infected transplant recipients in china. | 2013 | 23726627 |
| normalisation of angiogenic imbalance after intra-uterine transfusion for mirror syndrome caused by parvovirus b19. | we report a case of mirror syndrome caused by parvovirus b19, which resolved after intra-uterine transfusion. mirror syndrome is a rare condition characterised by a triad of foetal hydrops, generalized maternal oedema and placentomegaly. although the mechanism underlying the onset of this syndrome is unknown, it probably shares a common pathophysiologic origin with pre-eclampsia. our patient showed increased circulating levels of soluble fms-like tyrosine kinase 1 (sflt-1) and decreased levels o ... | 2013 | 23711762 |