| [effect of paeoniflorin on secretion of tgf-beta1 from macrophages in mice]. | to explore the effect of paeoniflorin (pae) on the production of transforming growth factor beta1 (tgf-beta1) from peritoneal macrophages(pms) stimulated by soluble egg antigen (sea) of schistosoma japonicum. | 2008 | 24812806 |
| effects of γ-interferon on hepatic fibrosis of schistosoma japonicum-infected mice. | to probe the effect of γ-ifn on hepatic fibrosis in schistosomiasis japonica. | 1997 | 27006573 |
| immune regulation in schistosomiasis japonica. | in schistosomiasis caused by the blood fluke, schistosoma japonicum, the major lesion responsible for clinical disease is the granuloma formed in the liver as an immune response to the eggs deposited there. in this review abram stavitsky discusses the most recent evidence for the mechanisms involved in the formation and spontaneous regression of the granulomas and presents a working hypothesis to guide future research. | 1987 | 25290435 |
| schistosoma mansoni cercarial elastase (smce): differences in immunogenic properties of native and recombinant forms. | the schistosoma mansoni cercarial elastase (smce) has previously been shown to be poorly immunogenic in mice. however, a minority of mice were able to produce antibodies against smce after multiple immunizations with crude preparations containing the enzyme. these mice were partially protected against challenge infections of s. mansoni. in the present study, we show that in contrast to the poor immunogenicity of the enzymatically active native form of smce derived from a crude preparation (cerca ... | 2017 | 28777067 |
| high prevalence of enteroparasites in children from ribeirão preto, são paulo, brazil. | to determine the prevalence of intestinal parasites and possible associated factors. | 2017 | 28562805 |
| characterization of schistosoma japonicum tetraspanning orphan receptor and its role in binding to complement c2 and immunoprotection against murine schistosomiasis. | schistosomiasis remains an important global public health problem, as millions of people are at risk of acquiring infection. an ideal method for sustainable control of schistosomiasis would be to develop an efficient vaccine. schistosomes can survive in the host vascular system by immune evasion, regulating the host complement cascade. schistosoma japonicum tetraspanning orphan receptor (sjtor) is a complement regulator, which is a tegument membrane protein. to date there is no experimental evid ... | 2017 | 28599669 |
| a candidate recombinant antigen for diagnosis of schistosomiasis japonica in domestic animals. | domestic animals infected with schistosoma japonicum are a major source of infection and play an important role in transmission to humans. a key strategy for the elimination of schistosomiasis is to control the sources of infection. in the present study, we identified a candidate diagnostic antigen-encoding gene, sjmrp1, the putative multidrug resistance protein 1 gene, by screening a cdna phage display library from 44-day-old s. japonicum worms using iggs from goat, cattle, and buffalo infected ... | 2017 | 28807301 |
| nested-pcr assay for detection of schistosoma japonicum infection in domestic animals. | schistosomiasis japonica is a common zoonosis. domestic animals are the primary source of infection and play an important role in disease transmission. the prevalence and infectivity of this disease in domestic animals in china have significantly decreased and, for this reason, diagnostics with a higher sensitivity have become increasingly necessary. it was reported that polymerase chain reaction (pcr)-based methods could be used to detect schistosome infection in humans and animals and presente ... | 2017 | 28407808 |
| innate scavenger receptor-a regulates adaptive t helper cell responses to pathogen infection. | the pattern recognition receptor (prr) scavenger receptor class a (sr-a) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. however, little is known about the role of sr-a in the host adaptive immune responses to pathogen infection. here we show with mouse models of helminth schistosoma japonicum infection and heat-inactivated mycobacterium tuberculosis stimulation that sr-a is regulated by pathogens and suppresses irf5 ... | 2017 | 28695899 |
| novel carbazole aminoalcohols as inhibitors of β-hematin formation: antiplasmodial and antischistosomal activities. | malaria and schistosomiasis are two of the most socioeconomically devastating parasitic diseases in tropical and subtropical countries. since current chemotherapeutic options are limited and defective, there is an urgent need to develop novel antiplasmodials and antischistosomals. hemozoin is a disposal product formed from the hemoglobin digestion by some blood-feeding parasites. hemozoin formation is an essential process for the parasites to detoxify free heme, which is a reliable therapeutic t ... | 2017 | 28395189 |
| salmonella typhimurium infection reduces schistosoma japonicum worm burden in mice. | coinfection of microorganisms is a common phenomenon in humans and animals. in order to further our understanding of the progress of coinfection and the possible interaction between different pathogens, we have built a coinfection mouse model with schistosoma japonicum and salmonella typhimurium, and used this model to investigate the systemic metabolic and immune responses using nmr-based metabonomics and immunological techniques. our results show that salmonella typhimurium (atcc14028) infecti ... | 2017 | 28465515 |
| schistosomiasis: drugs used and treatment strategies. | neglected tropical diseases (ntds) affect millions of people in different geographic regions, especially the poorest and most vulnerable. currently ntds are prevalent in 149 countries, seventeen of these neglected tropical parasitic diseases are classified as endemic. one of the most important of these diseases is schistosomiasis, also known as bilharzia, a disease caused by the genus schistosoma. it presents several species, such as schistosoma haematobium, schistosoma japonicum and schistosoma ... | 2017 | 28803725 |
| skull metastasis from the liver.case report and literature review. | calvarial metastasis from liver cirrhosis in the absence of a primary focus is exceptionally rare. few reports of metastases from hepatocellular carcinoma of an unknown primary focus have been published. | 2017 | 28844927 |
| anti-cd25 monoclonal antibody enhances the protective efficacy of schistosoma japonicum gst vaccine via inhibition of cd4(+)cd25(+)foxp3(+) regulatory t cells. | the effect of anti-cd25 monoclonal antibody (anti-cd25 mab) on the protection efficacy of schistosoma japonicum 26 kda gst (glutathione-s-transferase) vaccine was evaluated. mice were immunized with gst before infection with s. japonicum cercariae and then injected with anti-cd25 mab. the worm reduction rate was promoted from 24.18% in mice with gst immunization to 47.09% in mice with gst plus anti-cd25 mab. compared with the control group, the percentages of splenic cd4(+)cd25(+)foxp3(+) regula ... | 2017 | 28825137 |
| nlrp3 inflammasome activation results in liver inflammation and fibrosis in mice infected with schistosoma japonicum in a syk-dependent manner. | granulomatous and fibrosing inflammation in response to soluble egg antigen (sea) from schistosoma japonicum (s. japonicum) is the main pathological process of s. japonicum infection. inflammasome activation has recently been implicated in the pathogenesis of liver disease. however, the role of inflammasome activation in schistosomiasis-associated liver fibrosis (sslf) has not been extensively studied. in this study, it is demonstrated that the nlrp3 inflammasome is markedly activated in mouse h ... | 2017 | 28808303 |
| heat shock protein 47 effects on hepatic stellate cell-associated receptors in hepatic fibrosis of schistosoma japonicum-infected mice. | the study aimed to explore the regulation of heat shock protein 47 (hsp47) on expressions of receptors associated with hepatic stellate cell (hsc) in liver fibrosis mouse models induced by schistosoma japonicum (s. japonicum). mouse fibroblasts (nih/3t3) were transfected with hsp47 shrna plasmid by lipofectamine transfection, and experimental fibrosis in hscs was studied in s. japonicum mouse models treated with hsp47 shrna in vivo. hsp47 expression was assessed using western blot and real-time ... | 2017 | 28802097 |
| the regulation of regulation: il-10 increases cd4(+) cd25(+) regulatory t cells but impairs their immunosuppressive activity in murine models with schistosomiasis japonica or asthma. | cd4(+) cd25(+) foxp3(+) regulatory t cells (tregs) play an important role in maintaining immune homeostasis. interleukin 10 (il-10), a cytokine with anti-inflammatory capacities, also has a critical role in controlling immune responses. in addition, it is well known that production of il-10 is one of suppression mechanisms by tregs. however, the action of il-10 on tregs themselves remains insufficiently understood. in this study, by using a schistosoma japonicum (s. japonicum)-infected murine mo ... | 2017 | 28799262 |
| elevated serum antibody against schistosoma japonicum hsp60 as a promising biomarker for liver pathology in schistosomiasis. | the pathology associated with schistosoma japonicum (s. japonicum) infection in humans is attributed to parasite egg-induced granulomatous inflammation and fibrosis in the host liver. currently, a marker that is reliable, cheap, less device-dependent, and can be easily and repeatedly used on a large scale to monitor the progression of liver pathology in schistosomiasis japonica endemic areas is lacking. the levels of serum s. japonicum heat shock protein 60 (sjhsp60)-specific igg and its subtype ... | 2017 | 28798366 |
| colorectal cancer in a patient with intestinal schistosomiasis: a case report from kilimanjaro christian medical center northern zone tanzania. | colorectal cancer associated with chronic intestinal schistosomiasis has been linked with the chronic inflammation as a result of schistosomal ova deposition in the submucosal layer of the intestine. among all species schistosoma japonicum has been more linked to development of colorectal cancer as compared to schistosoma mansoni due to absence of population-based studies to support the association. despite the weak evidence, some cases have been reported associating s. mansoni with development ... | 2017 | 28768520 |
| evidence for an important role of host micrornas in regulating hepatic fibrosis in humans infected with schistosoma japonicum. | micrornas (mirnas) are short, non-coding rnas that repress the translation of target gene transcripts. they have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. we report here the first known mirnome and transcriptome analysis of human livers displaying advanced fibrosis due to schistosoma japonicum infection. we present evidence that hsa-mir-150-5p, hsa-mir-10a-5p, hsa-mir-199a-3p, hsa-mir-4521, hsa-mir-222/221, hsa-mir-663b ... | 2017 | 28739251 |
| suppression of vamp2 alters morphology of the tegument and affects glucose uptake, development and reproduction of schistosoma japonicum. | schistosomiasis caused by schsitosomes is a serious global public health concern. the tegument that surrounds the worm is critical to the schistosomes survival. the tegument apical membrane undergoes a continuous process of rupture and repair owing to membranous vacuoles fusing with the plasma membrane. vesicle-associated membrane protein 2 (vamp2), a member of soluble n-ethylmaleimide sensitive factor attachment protein receptor (snares) is required for membrane fusion. here, we used rna interf ... | 2017 | 28701752 |
| geographic strain differentiation of schistosoma japonicum in the philippines using microsatellite markers. | microsatellites have been found to be useful in determining genetic diversities of various medically-important parasites which can be used as basis for an effective disease management and control program. in asia and africa, the identification of different geographical strains of schistosoma japonicum, s. haematobium and s. mansoni as determined through microsatellites could pave the way for a better understanding of the transmission epidemiology of the parasite. thus, the present study aims to ... | 2017 | 28692692 |
| epigastric pain in a patient with cirrhosis. | •classic images of schistosomiasis.•pathology proved case.•impressive educational case. | 2017 | 28663683 |
| dynamics of th9 cells and their potential role in immunopathogenesis of murine schistosomiasis. | th1, th2, th17, treg and tfh cells play important roles in schistosomiasis. th9 cells secrete il-9 as a signature cytokine and contribute to several classes of inflammatory disease. however, the effects of th9 cells in schistosomiasis are unknown. we aimed to explore the dynamic changes and potential roles of th9 cells in the pathogenesis of hepatic egg granulomatous inflammation in mice infected with schistosoma japonicum. | 2017 | 28646920 |
| absence of batf3 results in reduced liver pathology in mice infected with schistosoma japonicum. | the involvement of cd8(+)t cells in schistosomiasis is being increasingly appreciated, but the underlying mechanism is not well defined. | 2017 | 28646891 |
| rodents, goats and dogs - their potential roles in the transmission of schistosomiasis in china. | schistosomiasis in china has been substantially reduced due to an effective control programme employing various measures including bovine and human chemotherapy, and the removal of bovines from endemic areas. to fulfil elimination targets, it will be necessary to identify other possible reservoir hosts for schistosoma japonicum and include them in future control efforts. this study determined the infection prevalence of s. japonicum in rodents (0-9·21%), dogs (0-18·37%) and goats (6·9-46·4%) fro ... | 2017 | 28637527 |
| schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. | the "hygiene hypothesis" is a theory try to explain the dramatic increases in the prevalence of autoimmune and allergic diseases over the past two to three decades in developed countries. according to this theory, reduced exposure to parasites and microorganisms in childhood is the main cause for the increased incidences of both t helper 1 (th1)-mediated autoimmunity and th2-mediated allergy. in this study, we investigated the impact of schistosoma japonicum infection on the allergic airway infl ... | 2017 | 28614408 |
| orthotopic liver transplantation from a donor with schistosoma japonicum. | | 2017 | 28603103 |
| identification and validation of a schistosoma japonicum u6 promoter. | rna polymerase iii promoters have been widely used to express short hairpin-rna (shrna), microrna (mirna), and small guide rna (sgrna) in gene functional analysis in a variety of organisms including schistosoma mansoni. however, no endogenous rna polymerase iii promoters have been identified in schistosoma japonicum. the lack of appropriate promoters in s. japonicum has hindered its gene functional analysis. identification of functional promoters in s. japonicum is therefore in urgent need. | 2017 | 28583151 |
| molecular characterization and expression profile of nanos in schistosoma japonicum and its influence on the expression several mammalian stem cell factors. | pluripotent stem cells, called neoblasts, are well known for the regenerative capability and developmental plasticity in flatworms. impressive advancement has been made in free-living flatworms, while in case of its parasitic counterpart, neoblast-like stem cells have attracted recent attention for its self-renewal and differentiation capacity. nanos is a key conserved post-transcriptional regulator critical for the formation, development, and/or maintenance of the pluripotent germ line stem cel ... | 2017 | 28555405 |
| characteristics of il-9 induced by schistosoma japonicum infection in c57bl/6 mouse liver. | liver granulomatous inflammation and fibrosis were the primary pathological changes observed during schistosoma japonicum (s. japonicum) infection. in the present study, the characteristics of il-9 were investigated in the liver of s. japonicum infection c57bl/6 mice. immunofluorescence, qrt-pcr, and elisa results demonstrated that the expression of il-9 significantly increased after infection (p < 0.01). facs results indicated that the peak of il-9(+) th9 cells in the liver mononuclear cells ap ... | 2017 | 28539607 |
| structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy. | the antischistosomal prodrug oxamniquine is activated by a sulfotransferase (sult) in the parasitic flatworm schistosoma mansoni. of the three main human schistosome species, only s. mansoni is sensitive to oxamniquine therapy despite the presence of sult orthologs in schistosoma hematobium and schistosoma japonicum the reason for this species-specific drug action has remained a mystery for decades. here we present the crystal structures of s. hematobium and s. japonicum sults, including s. hema ... | 2017 | 28536265 |
| lessons from a 15-year-old boy with advanced schistosomiasis japonica in china: a case report. | schistosomiasis is a chronic, parasitic disease caused by flukes (trematodes) of the genus schistosoma, which presents the most important global burden of the 17 neglected tropical diseases listed by the world health organization. china has made great achievements in schistosomiasis control, and now china is planning to move forward, to eliminate schistosomiasis within 2020, but the fact cannot be denied that the possibility of schistosome infection is still there in some endemic due to its zoon ... | 2017 | 28508167 |
| recruitment of neutrophils mediated by vγ2 γδ t cells deteriorates liver fibrosis induced by schistosoma japonicum infection in c57bl/6 mice. | conventional adaptive t cell responses contribute to the pathogenesis of schistosoma japonicum infection, leading to liver fibrosis. however, the role of gamma-delta (γδ) t cells in this disease is less clear. γδ t cells are known to secrete interleukin-17 (il-17) in response to infection, exerting either protective or pathogenic functions. in the present study, mice infected with s. japonicum are used to characterize the role of γδ t cells. combined with the infection of s. japonicum, an extrem ... | 2017 | 28507072 |
| plasma d-dimer can effectively predict the prospective occurrence of ascites in advanced schistosomiasis japonica patients. | china still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. d-dimer is a fibrin degradation product. as ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with d-dimer and other clinical easy-achievable indicators. a case-control study nested in a prospective cohort was conducted in schistosomiasis-endemic area of southern china. a total of 291 patients of advanc ... | 2017 | 28506039 |
| vaccination with recombinant paramyosin in montanide isa206 protects against schistosoma japonicum infection in water buffalo. | schistosomiasis japonica is a zoonosis and presents significant public health problems in china and the philippines. vaccines targeting domestic animals constitute attractive control measures. | 2017 | 28504194 |
| recombinant sjp40 protein enhances p27 promoter expression in hepatic stellate cells via an e2f1-dependent mechanism. | the p27 protein plays a critical role in cell cycle arrest. our previous studies have demonstrated that recombinant p40 protein from schistosoma japonicum (rsjp40) could induce g1 phase arrest of cell cycle. we, therefore, attempted to observe the effect of rsjp40 on p27 promoter activity in lx-2 cells and to explore its potential mechanisms in this study. using both western blot and dual-luciferase reporter assay, we demonstrated that rsjp40 could enhance the expression of p27 in lx-2 cells. re ... | 2017 | 28489573 |
| mhc ii(-), but not mhc ii(+), hepatic stellate cells contribute to liver fibrosis of mice in infection with schistosoma japonicum. | hepatic stellate cells (hscs) are considered as the main effector cells in vitamin a metabolism and liver fibrosis, as well as in hepatic immune regulation. recently, researches have revealed that hscs have plasticity and heterogeneity, which depend on their lobular location and whether liver is normal or injured. this research aimed to explore the biological characteristics and heterogeneity of hscs in mice with schistosoma japonicum (s. japonicum) infection, and determine the subpopulation of ... | 2017 | 28483578 |
| therapeutic effect of schistosoma japonicum cystatin on bacterial sepsis in mice. | sepsis is a life-threatening complication of an infection and remains one of the leading causes of mortality in surgical patients. bacteremia induces excessive inflammatory responses that result in multiple organ damage. chronic helminth infection and helminth-derived materials have been found to immunomodulate host immune system to reduce inflammation against some allergic or inflammatory diseases. schistosoma japonicum cystatin (sj-cys) is a cysteine protease inhibitor that induces regulatory ... | 2017 | 28482922 |
| a schistosoma japonicum infection promotes the expansion of myeloid-derived suppressor cells by activating the jak/stat3 pathway. | myeloid-derived suppressor cells (mdscs), a heterogeneous group of immune cells from the myeloid lineage, play an important part in suppression of host immune responses during many pathologic conditions, including cancer and infectious diseases. thus, understanding the functional diversity of these cells as well as the underlying mechanisms is crucial for the development of disease control strategies. the role of mdscs during schistosoma japonicum infection, however, is not clear, and there is a ... | 2017 | 28476935 |
| immunization with recombinant schistosome adenylate kinase 1 partially protects mice against schistosoma japonicum infection. | highly effective and safe prophylactic vaccines are urgently needed to sustainably control schistosomiasis, one of the most serious endemic zoonoses in china. in this study, we characterized adenylate kinase 1 from schistosoma japonicum (sjak1), a phosphotransferase that regulates cellular energy and metabolism, and evaluated its potential as a recombinant vaccine. based on real-time quantitative pcr, western blot, and immunolocalization, sjak1 is active throughout the life of the worm, although ... | 2017 | 28455627 |
| soluble egg antigen activates m2 macrophages via the stat6 and pi3k pathways, and schistosoma japonicum alternatively activates macrophage polarization to improve the survival rate of septic mice. | sepsis is one of the most challenging health problems worldwide. our previous study showed that chronic schistosoma japonica (sj) infection might increase serum anti-inflammatory factors to play a protective role, thus improving the survival rate of septic mice. further research revealed that sj infection promoted j774a.1 macrophage differentiation into m2 macrophages; suppressed lps-induced activation of m1 macrophages; up-regulated cd163, il-10, and tgf-β1 expression; inhibited tnf-α and inos ... | 2017 | 28419526 |
| assessing environmental factors associated with regional schistosomiasis prevalence in anhui province, peoples' republic of china using a geographical detector method. | schistosomiasis is a water-borne disease caused by trematode worms belonging to genus schistosoma, which is prevalent most of the developing world. transmission of the disease is usually associated with multiple biological characteristics and social factors but also factors can play a role. few studies have assessed the exact and interactive influence of each factor promoting schistosomiasis transmission. | 2017 | 28416001 |
| development of monoclonal antibodies against sj29 and its possible application for schistosomiasis diagnosis. | timely schistosoma japonicum detection improves outcomes in schistosomiasis. here, we established a double antibody sandwich elisa to detect schistosoma japonicum. | 2017 | 28412409 |
| identification and functional characterisation of a schistosoma japonicum insulin-like peptide. | previous studies have shown that insulin receptors in schistosomes, triggered by host insulin, play an important role in parasite growth, development and fecundity by regulating glucose metabolism. however, limited information is available on the recently identified endogenous insulin-like peptide (ilp) in blood flukes. | 2017 | 28407789 |