| [antimycobacterial beta-aminoketones]. | | 1987 | 3117015 |
| inhibition of growth of mycobacterium tuberculosis in the presence of auramine. | | 1987 | 3117540 |
| [action of synthetic antitubercular agents on the metabolism of mycobacterium tuberculosis]. | | 1987 | 3117586 |
| detection of tubercle bacilli in sputum smear by floatation method--a reappraisal. | | 1987 | 3117680 |
| gamma interferon reverses inhibition of leukocyte bactericidal activity by a 25-kilodalton fraction from mycobacterium tuberculosis. | in this study we examined the effects of mycobacterium tuberculosis cell extracts on the phagocytic activity of polymorphonuclear leukocytes and cultured peripheral blood monocytes. m. tuberculosis cell extracts were fractionated on sephacryl s-200 columns, and a 25-kilodalton glycolipoprotein was shown to inhibit the intracellular killing ability of these leukocytes but had no effect on their phagocytic potential. this same fraction inhibited fusion of phagosomes with lysosomes, as assessed by ... | 1987 | 3117692 |
| effects of long-term treatment with d-penicillamine on antigen-induced arthritis in rabbits: studies on in vivo articular chondrocyte damage and in vitro collagen biosynthesis by cultured chondrocytes. | the effects of a long-term (120 days) treatment with d-penicillamine (dp) (50 mg/kg/day; i.v.) on antigen-induced arthritis were studied in rabbit. they were investigated by the terminal histological examination of the joints of different groups of rabbits (unimmunized treated or untreated, immunized treated or untreated) and the study of collagen and non-collagen protein biosynthesis by cultured chondrocytes obtained from articular cartilage of the same groups of animals. treatment with d-penic ... | 1987 | 3117714 |
| the ex vivo measurement of malondialdehyde and chemiluminescence as possible indices for anti-inflammatory drug evaluation. | a well-established model of foot-pad oedema in the rat, an example of a cell-mediated hypersensitivity reaction, was used in this study. male rats were immunized on day 0 with freund's complete adjuvant (fca) and then challenged 6 days later with fca in one hind paw. within 4 h of the initiation of this acute inflammatory reaction, the presence of free radicals was detected as luminol-amplified chemiluminescence (lac) directly from the inflamed paws. in addition, an increase in malondialdehyde ( ... | 1987 | 3117715 |
| [extrapulmonary tuberculosis today]. | in the past ten years 162 patients with extrapulmonary tuberculosis have been admitted to this hospital. they constituted 10% of the total number of patients with tuberculosis seen. the percentage of immigrants with extra-pulmonary disease was 39%, which was not only higher than the percentage of immigrants with pulmonary tuberculosis (25%) but also than their percentage in the total population (13%). the sites primarily affected were the pleura (28%), skeleton (23%) and urogenital tract (21%). ... | 1987 | 3118456 |
| [open tuberculosis with radiologically negative cavity findings]. | non-cavernous bacillary tuberculosis is observed with relatively increasing frequency nowadays. most patients affected have very few or no symptoms, and radiographs usually show circumscribed lesions. the essential feature is the low infection risk due to the small number of bacilli excreted. | 1987 | 3118459 |
| [the basic achievements and tasks in modern phthisiology]. | | 1987 | 3118491 |
| [importance of microbiological research in correcting the antibacterial therapy of tuberculosis]. | long-term observations showed the importance of the phenomenon of the drug resistance of mycobacterium tuberculosis in phthisiological clinical practice and its tendency in recent years. methods for individual selection of an optimum drug combination were developed and tested, its efficacy was shown. | 1987 | 3118492 |
| [effectiveness of the combined therapy of pulmonary mycobacterial infections depending on the species classification of the causative agent]. | the purpose of the study was to define the effect of specific tubercle bacillus on a course of pulmonary tuberculosis and the role of atypical mycobacteria in the development of "nontuberculous mycobacterioses". a total of 1896 mycobacterial cultures isolated from 1285 patients were identified. mycobacterial cultures from 86 patients were identified as m. bovis; mycobacteria of the "atypical" group from 12 patients were agents of nontuberculous mycobacterioses. cultures in 7 patients were identi ... | 1987 | 3118493 |
| susceptibility testing of mycobacterium tuberculosis to pyrazinamide. | one hundred and sixty clinical isolates of mycobacterium tuberculois were tested for their sensitivity to pyrazinamide (pza) using the conventional proportion method (middlebrook 7h10 agar) and the results compared to the pyrazinamidase (pzase) activity of the strains. the correlation between strains susceptible to pza and the production of pzase was 99%. none of the isolates were exclusively resistant to pza. at present the rate of initial pza resistance in kanton zurich is 0.6%. | 1987 | 3118600 |
| [bilateral abscess of the psoas with aero-anaerobic digestive flora in advanced tuberculosis]. | the authors report a case of bilateral psoas abscess without spondylodiscitis, occurring in the course of an advanced pleuro-pulmonary tuberculosis. the dual bacteriological composition of the pus with an aero-anaerobic flora on direct examination, and mycobacterium tuberculosis in the culture, as well as the presence of an obstructive appendicitis noticed during the surgery, open the discussion of its pathogenesis. | 1987 | 3118756 |
| demonstration that the galactosyl and arabinosyl residues in the cell-wall arabinogalactan of mycobacterium leprae and mycobacterium tuberculosis are furanoid. | by a complex process involving methylation, partial hydrolysis with acid, reduction with sodium borodeuteride, ethylation, further hydrolysis and reduction, and subsequent capillary gas-liquid chromatography-mass spectrometry of the derived alditol acetates, it was established that the arabinogalactans of mycobacterium leprae and mycobacterium tuberculosis contain arabinofuranyosyl and galactofuranosyl residues exclusively. thus, the covalently bound, highly immunogenic arabinogalactan of mycoba ... | 1987 | 3119212 |
| the role of gamma-interferon, vitamin d3 metabolites and tumour necrosis factor in the pathogenesis of tuberculosis. | endotoxin (lps)-triggered release of tumour necrosis factor (tnf) from human monocytes is high for the first 3 days in culture, and then falls to a trough between days 4 and 6. this trough is less deep if the cells are cultured in the presence of indomethacin. if monocytes are cultured in the presence of either recombinant gamma-interferon or 1,25-(oh)2 vitamin d3, their capacity for lps-triggered tnf release is increased. live virulent mycobacterium tuberculosis can substitute for the lps, and ... | 1987 | 3119471 |
| allergenic and blastogenic reactivity of three antigens from mycobacterium tuberculosis in sensitized guinea pigs. | three antigens from a culture filtrate of mycobacterium tuberculosis h37rv were purified by affinity chromatography, using monoclonal antibodies. the molecular weights of the purified antigens are 17,000 to 19,000, 32,000 to 33,000, and 39,000, respectively, and by their migration patterns in sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing and nonreducing conditions, they all appeared to be single-chain polypeptides. western blot and enzyme-linked immunosorbent assay ana ... | 1987 | 3119491 |
| inhibition by 1,25(oh)2-vitamin d3 of the multiplication of virulent tubercle bacilli in cultured human macrophages. | historically, sunlight has seemed to fortify antituberculosis resistance. evidence is presented here suggesting a role for vitamin d in this effect. the active metabolite of this photosynthesized vitamin, 1,25-dihydroxy-vitamin d3 (1,25d), promotes maturation and activation of human monocytes and macrophages (mps). therefore, it was tested for ability to protect mps against virulent tubercle bacilli. mps were derived by 7-day culture from blood monocytes, infected with the bacilli, and exposed t ... | 1987 | 3119492 |
| immunological activity of a 14-kilodalton recombinant protein of mycobacterium tuberculosis h37rv. | a 14-kilodalton peptide antigen from mycobacterium tuberculosis was isolated from an escherichia coli lambda gt 11 recombinant dna clone and was identified by western blotting (immunoblotting) with monoclonal antibody tb68. immunization of mice and guinea pigs with the recombinant peptide (rtb68) induced in vitro lymphoproliferative responses in draining lymph node lymphocyte cultures as well as in vivo delayed-type hypersensitivity reactions. moreover, rtb68 was found both to induce and to cros ... | 1987 | 3119499 |
| an appraisal of epidemiologic, clinical, bacteriologic, histopathologic, and immunologic parameters in cutaneous tuberculosis. | cutaneous tuberculosis incidence was recorded as 0.15%. of the 42 patients, 23 had scrofuloderma, 17 lupus vulgaris, and 2 tuberculosis verrucosa cutis. both men and women were affected by the disease in the second and third decades. its duration was variable. an affirmative family history was elicited in five scrofuloderma patients. the clinical expression largely conformed to the ritual text. variation in mantoux test positivity was unremarkable. the disparity in the demonstration of bacilli i ... | 1987 | 3119506 |
| [technical guidance in tuberculosis laboratory works in indonesia--technical transfer of sputum culture examination and training of microscopists]. | | 1987 | 3119910 |
| [new diagnostic methods in meningeal tuberculosis]. | | 1987 | 3119953 |
| [diagnosis and characteristics of the clinical course of newly detected pulmonary tuberculosis in patients with a scanty and single isolation of bacteria]. | | 1987 | 3120175 |
| [value of biological and culture methods of examination in diagnosing tuberculosis]. | | 1987 | 3120176 |
| rapid automated methods (bactec system) in clinical mycobacteriology. | by using radiometric techniques, it is now possible to measure mycobacterial growth, to identify organisms as part of the mycobacterium tuberculosis complex, and to perform drug susceptibility testing in a matter of days rather than weeks or months. the method is based on the elaboration of radiolabeled carbon dioxide (c14o2) by metabolically active mycobacteria that consume an exclusive carbohydrate substrate containing the labelled carbon. field studies have shown the method to be sensitive an ... | 1986 | 3120267 |
| studies of antituberculosis chemotherapy with an in vitro model of human tuberculosis. | testing new drugs or drug combinations for activity against tuberculosis is highly problematic: clinical therapy trials are expensive and time-consuming; animal trial results may not be applicable to humans; and simple in vitro testing on culture medium excludes a vital component of the natural infection, namely the macrophage. described here is a technique to treat with chemotherapy human macrophages that have been infected ex vivo with tubercle bacilli. briefly discussed are the results of tre ... | 1986 | 3120268 |
| drug resistance in tuberculosis control. | | 1987 | 3120383 |
| [prolonged-action antitubercular preparation]. | | 1987 | 3120416 |
| adjuvant polyarthritis and the pseudosynovitis. | the cavity lining of a six day old subcutaneous air pouch in rats resembles normal synovium in morphology and responds in a comparable manner during development of polyarthritis. the ability of newly formed pouches (one and two days old) to respond similarly to polyarthritogen was examined here. positive macro and microscopic changes similar to those seen in the six day old pouch were observed in rats previously inoculated with adjuvant. the intensity of some of these changes varied between pouc ... | 1987 | 3120508 |
| cutaneous mycobacteriosis: occurrence and significance in two patients with the acquired immunodeficiency syndrome. | | 1987 | 3120648 |
| [studies on monoclonal antibodies in the diagnosis of tuberculosis]. | | 1987 | 3121192 |
| in vitro activity of ciprofloxacin and ofloxacin against the mycobacterium avium-intracellulare complex. | the in vitro activity of ciprofloxacin and ofloxacin against strains of mycobacterium avium-intracellulare complex were studied by the standard 1% proportion method. thirty-eight of 100 strains (30%) were inhibited by ciprofloxacin at 2 micrograms/ml and 11 of 30 strains (37%) were inhibited by ofloxacin at 8 microm/ml. patients having these more susceptible isolates may potentially benefit from therapy with these agents [corrected]. | 1987 | 3121243 |
| a direct effect of glucocorticoid hormones on the ability of human and murine macrophages to control the growth of m. tuberculosis. | recombinant murine gamma interferon (rifn-gamma) causes powerful inhibition of m. tuberculosis by murine peritoneal macrophages. this inhibition is totally abrogated by glucocorticosteroid hormones. in contrast, glucocorticoids do not oppose the weak inhibition of m. tuberculosis by human macrophages which can be induced with human rifn-gamma, nor do they reduce the effect in this system of 1,25-(oh)2 vitamin d3. however, glucocorticoid hormones do decrease the baseline inhibition of m. tubercul ... | 1987 | 3121374 |
| antituberculous drug resistance in a predominantly black veteran population. | | 1987 | 3122077 |
| [bacteria isolation and immunological reactivity in patients with recurrent pulmonary tuberculosis]. | | 1987 | 3122199 |
| [outlook for using a short course of chemotherapy in tuberculosis]. | | 1987 | 3122200 |
| [improved methods of isolating altered forms of mycobacterium tuberculosis in patients with stable destructive changes in lung tissue]. | | 1987 | 3122201 |
| [new possibilities in the rapid bacteriologic diagnosis of pulmonary tuberculosis]. | | 1987 | 3122421 |
| studies on clofazimine-resistance in mycobacteria: is the inability to isolate drug-resistance mutants related to its mode of action? | this study showed that clofazimine was not radiomimetic, it was not a mutagenic compound, it was not an inducer of prophage-lambda, and it did not eliminate plasmids from appropriate host bacteria. the drug caused an effective inhibition of the growth of mycobacterium aurum, and also inhibited the growth cycle of the mycobacteriophage d29. cross-resistance between clofazimine, streptomycin and rifampicin could not be demonstrated. drug-resistance mutants towards clofazimine could not be isolated ... | 1987 | 3122464 |
| evaluation of a third sequential tuberculin skin test in a chronic care population. | to evaluate factors that might influence the accuracy of tuberculin tests in identifying elderly persons recently infected with mycobacterium tuberculosis, we performed as many as 3 sequential administrations of 5 tuberculin units of purified protein derivative in 1,726 persons residing in chronic care facilities. significant reactions (greater than or equal to 10 mm of induration) to 1 of 3 tests were found in 702 (40.7%) persons. of these, 68% were found with test 1, 22.5% with test 2, and 9.5 ... | 1988 | 3122610 |
| stimulation by anti-idiotype antibody of murine t cell responses to the 38 kd antigen of mycobacterium tuberculosis. | rabbit antisera raised against eight monoclonal antibodies (moab) binding to distinct mycobacterial antigens revealed individual anti-idiotype specificities following cross-absorption with normal mouse globulin. only one of these antibodies (rb71), directed towards an m. tuberculosis-specific epitope on the 38 kd protein antigen was able to stimulate mouse t cell responses which had 'internal image' characteristics. this was demonstrated by anti-id induced in vitro proliferation of lyt 1.2+ t ce ... | 1987 | 3123105 |
| evaluation of gen-probe dna hybridization systems for the identification of mycobacterium tuberculosis and mycobacterium avium-intracellulare. | the gen-probe dna hybridization system, rapid diagnostic assays for the identification of mycobacterium tuberculosis (mtb) complex and mycobacterium avium-intracellulare (maic) complex, were evaluated. designed to identify a primary mycobacterial isolate, the former correctly identified 91 of 92 mtb and all 27 non-mtb isolates and controls when compared with conventional identification methods for a sensitivity of 98.91% and specificity of 100%. the latter correctly identified 63 of 64 maic isol ... | 1987 | 3123122 |
| absence of antimycobacterial synergism between garlic extract and antituberculosis drugs. | garlic extract inhibited the growth of four strains of mycobacterium tuberculosis, three strains of mycobacterium avium-intracellulare, and three strains of mycobacterium kansasii in concentrations ranging from 0.98 mg/ml to 2.94 mg/ml. synergism could not be demonstrated when garlic extract was added to various concentrations of four commonly used antituberculous drugs. | 1987 | 3123123 |
| high level of interferon gamma in tuberculous pleural effusion. | it has been observed that t-lymphocytes of patients with tuberculosis produce interferon gamma (ifn gamma) in vitro. based on this idea, we studied ifn gamma in pleural fluid and serum. we studied 80 patients with pleural effusion; 30 patients with tuberculous pleurisy had high ifn gamma concentrations in pleural fluid. patients with malignant pleural effusions, nonspecific pleural effusion, parapneumonic effusions and pleural transudates had low levels. the ifn gamma levels were higher in those ... | 1988 | 3123150 |
| diagnostic value of bronchoalveolar lavage in suspected pulmonary tuberculosis. | of 222 patients suspected of having pulmonary tuberculosis (pt), studied during a one-year period, we performed fiberoptic bronchoscopy together with bronchoalveolar lavage (bal), bronchial washing and postbronchoscopy sputum smears and löwenstein cultures in 20 patients. bronchoalveolar lavage proved to be the most effective method leading to diagnosis in 17 of 20 cases. diagnosis was obtained in 11 of 20 cases using bronchial washing and postbronchoscopy sputum. the results of this study sugge ... | 1988 | 3123151 |
| chemotherapy of pulmonary tuberculosis in britain. | | 1988 | 3123192 |
| effect of insulin immunization on glucose tolerance in normal rats. | normal rats were immunized with insulin and freund's adjuvant and submitted to an intravenous glucose tolerance test. plasma glucose and free and total iri levels were determined and compared to those observed in untreated rats, and in animals injected with the freund's adjuvant used for the immunization procedure. in six of the 15 insulin injected animals, a significant amount of iri (more than 100 mu/l) was found to circulate in bound form. in these animals, the fasting plasma glucose concentr ... | 1987 | 3123287 |
| mycobacteriocin typing of mycobacterium tuberculosis isolated from patients in south india, hong kong & britain. | | 1987 | 3123382 |
| use of multiple media for the cultivation of mycobacteria from specimens other than sputum. | | 1987 | 3123383 |
| modulation of macrophage lysosomal ph by mycobacterium tuberculosis-derived proteins. | macrophage lysosomal ph was significantly (greater than 1 ph unit) increased in a reversible, concentration-dependent manner characterized by a saturable and cyclic kinetics after exposure to culture filtrate protein extract derived from mycobacterium tuberculosis. lysosomal alkalinization peaked 30 min after administration of culture filtrate protein extract to cells of the macrophagelike cell line j774a.1. the alkalinization was reversible, and a second peak was observed approximately 60 min a ... | 1988 | 3123394 |
| [mycobacteria and the cause of rheumatoid arthritis]. | | 1988 | 3124006 |
| [relation between chemical structure, antitubercular activity and hepatotoxicity of 2-alkylthio-6-benzamidobenzothiazoles]. | the paper investigates the relationships between hydrophobic parameters and antituberculotic activity of 2-alkylthio-6-benzamidobenzothiazoles, tested on inh-resistant strain of mycobacterium tuberculosis. in the group of compounds with linear alkyl substituents in position 2, the tuberculostatic effect is increasing with decrease of lipophility of alkyls. branching of the alkyls strongly increases the activity. the hepatotoxicity of compounds under study was investigated by means of the activit ... | 1987 | 3124140 |
| the antigens of mycobacterium tuberculosis, h37rv, studied by crossed immunoelectrophoresis. comparison with a reference system for mycobacterium bovis, bcg. | on the basis of a previously developed reference system for mycobacterium bovis, bcg, in crossed immunoelectrophoresis (cie), antigens of mycobacterium tuberculosis were identified in an analogous system. a majority of the numbered lines in the bcg system were also present and identified in the m. tuberculosis system. the corresponding antigens in the two systems were identified by dual dilution in cie, and using monospecific antisera and monoclonal antibodies. some of the antigens were specific ... | 1988 | 3124264 |
| nontuberculous mycobacteria and mycobacterium bovis as a cause of human disease in argentina. | fifteen laboratories from six regions of the country participated in the present trial covering the three years period 1982-84 during which they obtained 13544 mycobacterial cultures from 7672 patients. of the total isolates, 437 (3.22%) were nontuberculous mycobacteria and 49 (0.36%) mycobacterium bovis. the remaining cultures were identified as m. tuberculosis, which was the infectious agent in 7609 cases (99.17%). a further 36 cases (0.47%) were due to m. bovis and the remaining 27 to nontube ... | 1987 | 3124310 |
| enzyme-linked immunosorbent assay (elisa) of antibodies to purified protein derivative (ppd) in the diagnosis of active tuberculosis: evaluation of its potential and limitation in a high prevalence area. | sera from patients with active tuberculosis were assayed for igg antibodies to purified protein derivative (ppd) by an enzyme-linked immunosorbent assay (elisa) technique. eighty seven of the 112 patients (78%) with sputum culture-positive, and 57 of 78 patients (73%) with sputum culture-negative, pulmonary tuberculosis had positive serology. seventeen of 19 patients (89%) with renal tuberculosis (demonstrable lesion on intravenous pyelography) had antibody to ppd, whereas only 3 of 9 patients ( ... | 1987 | 3124311 |
| [a new method of determining the virulence of nontubercular mycobacteria and weakly virulent mycobacterium tuberculosis]. | a new method for enhancing the sensitivity of white mice to infection with faintly virulent mycobacteria is proposed. the method consists in the sensitization of animals with pertussis monovaccine introduced in a single-intraperitoneal injection 7 days before the infection of animals with the culture under study. the method permitted the detection of residual virulence in all opportunistic mycobacteria under study. | 1987 | 3124419 |
| monoglycosyldiacylphenol-phthiocerol of mycobacterium tuberculosis and mycobacterium bovis. | the structure of a minor glycolipid of m. tuberculosis (strain canetti) is shown to be 2-o-methyl-alpha-l-rhamnosyldiacylphenol-phthiocerol. a similar compound with non-methylated rhamnose as sugar moiety was also detected. in the course of this work, the structure of mycoside b from mycobacterium bovis was reexamined, and was shown to be identical to that of the 2-o-methylrhamnosyldiacylphenol-phthiocerol of the canetti strain, while it was described as a 2-o-methyl-beta-d-rhamnosyl derivative ... | 1988 | 3124883 |
| superficial mycobacterial lymphadenitis in saskatchewan. | a total of 43 bacteriologically verified cases of superficial mycobacterial lymphadenitis were reported in saskatchewan between 1981 and 1986; 35 (81%) were due to mycobacterium tuberculosis. among the eight cases (19%) due to nontuberculous mycobacteria the agent most frequently isolated was m. avium-intracellulare. five additional cases were smear-positive and culture-negative. direct smears of node tissue or aspirate were positive for acid-fast bacilli in 7 (88%) of the 8 cases of nontubercul ... | 1988 | 3124949 |
| in vitro susceptibility of mycobacterium tuberculosis to ofloxacin and ciprofloxacin in combination with rifampin and isoniazid. | the in vitro susceptibility of mycobacterium tuberculosis to new quinolones, ofloxacin and ciprofloxacin, alone and in combination with rifampin or isoniazid, was studied by the agar dilution method. at a concentration of 1 mg/l or lower of ofloxacin and ciprofloxacin, 90% of the strains were inhibited. a synergistic effect with rifampin and with isoniazid was demonstrated. | 1987 | 3124964 |
| in vitro activity of five new quinolones against cultivable mycobacteria. | | 1987 | 3125049 |
| in vitro activity of four fluoroquinolones against eighty-six isolates of mycobacteria. | the in vitro activity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin against 86 strains of mycobacteria was evaluated by broth dilution. while mycobacterium avium, mycobacterium scrofulaceum and mycobacterium chelonae were resistant to all four antibacterials, the susceptibility of the other species, mycobacterium tuberculosis, mycobacterium kansasii, mycobacterium xenopi and mycobacterium fortuitum, depended on the antibiotic. ofloxacin and ciprofloxacin (mic90: 0.5 - 2 mg/l) were more ... | 1987 | 3125050 |
| [development of new vaccination strategies against tuberculosis]. | tuberculosis still represents a major global health problem. despite the possibility of chemotherapeutic treatment, effective control of the disease could best be achieved by the adjunct of active vaccination procedures. bcg-vaccination, unfortunately proved less effective in developing countries than originally thought. therefore, the development of a new generation of tuberculosis vaccines should be considered. recent achievements in biotechnology have laid the basis for such a development. in ... | 1987 | 3125102 |
| aids and tuberculosis. | | 1987 | 3125148 |
| identification of major slowly growing pathogenic mycobacteria and mycobacterium gordonae by high-performance liquid chromatography of their mycolic acids. | a rapid, reverse-phase high-performance liquid chromatography method was used to detect rho-bromophenacyl mycolic acid ester patterns for strains of four major pathogenic mycobacterium species and for the most commonly encountered saprophytic species, mycobacterium gordonae. mycobacteria in low numbers (2.5 x 10(6) cfu) were detected and identified to the species level. standard chromatographic patterns characteristic of each species were established. simple pattern recognition enabled rapid ide ... | 1988 | 3125214 |
| identifying mycobacterium tuberculosis cultures by gas-liquid chromatography and a computer-aided pattern recognition model. | a procedure that uses gas-liquid chromatography and a pattern recognition computer model was developed for distinguishing cultures of mycobacterium tuberculosis from cultures of other mycobacteria, common bacteria, and fungi. in this procedure, a sample of a culture preparation is methanolyzed and trimethylsilylated sequentially and injected into a gas chromatograph equipped with a flame ionization detector. a pattern recognition procedure computes an error score by comparing the gas-liquid chro ... | 1988 | 3125216 |
| the first joint thelep-sasakawa memorial health foundation workshop on experimental chemotherapy of leprosy. | | 1987 | 3125288 |
| two groups of mycobacterium avium complex strains determined according to the susceptibility to rifampicin and ansamycin. | mycobacterium avium complex strains previously not exposed to any antituberculosis agents could be divided into two groups according to their susceptibility to rifampicin and ansamycin; one group susceptible to 80 micrograms/ml rifampicin and to 1.25 micrograms/ml ansamycin, and another resistant to these concentrations. in each group, the ratio of the minimal inhibitory concentration of ansamycin against that of rifampicin was greatly different depending on the strain. this naturally occurring ... | 1987 | 3125413 |
| [value of various methods of the diagnosis of focal pulmonary tuberculosis]. | | 1987 | 3125537 |
| [intermittent chemotherapy of patients with fibrous-cavernous pulmonary tuberculosis in a hospital]. | | 1987 | 3125538 |
| [collective experience with bacteriophage typing and identification of mycobacterium tuberculosis isolated in the ussr and cssr]. | | 1987 | 3125539 |
| [effect of low-energy irradiation with the helium-neon laser on mycobacterium tuberculosis]. | | 1987 | 3125540 |
| [muramyl dipeptide (mdp): its origin, mechanism of action and prospects for its use]. | | 1987 | 3125614 |
| spontaneous fracture of the sternum and sternal tuberculosis. | | 1987 | 3125625 |
| comparison of ribosomes and ribosomal proteins of sensitive and resistant mycobacteria. | ribosomal proteins from mycobacterium tuberculosis h37 rv were analyzed by polyacrylamide gel electrophoresis and 73 proteins were separated. the 30s subunit consists of 26 proteins, the 50s subunit of 41 proteins, 6 proteins of the ribosomes could not be shown in the subunits. the molecular weights for the proteins of the 30s subunit are 9100-43500, and for the proteins of the 50s subunit 8000-46000. the sedimentation coefficient have values of 28.8s and 47.7s. it was demonstrated that streptom ... | 1987 | 3125705 |
| antitumor effects of polysaccharides of human-type mycobacterium tuberculosis on collagenation in human cancer xenografts. | the most important activity of ssm is stimulation of collagenation from cancer-infiltrated stromal tissue which confines the cancer. in order to elucidate the proliferative responses of collagen in cancer, single and double xenografts were prepared by transplantation of human gastric cancer (hgc), human lung cancer (hlc), and nb41a3 (mouse neuroblastoma) into nude mice. the collagen responses were dependent on the type of cancer cell used, particularly the cell membranes. ssm distinctly stimulat ... | 1987 | 3125716 |
| treatment of tuberculosis. | | 1988 | 3125723 |
| implications of emerging isoniazid resistance to mycobacterium tuberculosis in korea. | | 1988 | 3125824 |
| immunopathogenesis in tuberculosis. part ii: humoral mechanism of resistance. | | 1987 | 3126132 |
| a gene from mycobacterium tuberculosis which is homologous to the dnaj heat shock protein of e. coli. | | 1988 | 3126487 |
| radiometric method for pyrazinamide susceptibility testing of mycobacterium tuberculosis in egg-yolk-enriched bactec 12a medium. | a radiometric method for testing the susceptibility of mycobacterium tuberculosis to pyrazinamide in egg-yolk-enriched 12a medium (ph 5.5) is described. we obtained 100% agreement between the 7h10 agar method with 25 microgram of pyrazinamide per ml and the modified radiometric method with a drug concentration of 50 microgram/ml in tests of 90 clinical isolates. | 1988 | 3126704 |
| enzyme-linked immunosorbent assay for the detection of antibodies against mycobacterium tuberculosis in bronchial washings and serum. | this prospective study evaluates an enzyme-linked immunosorbent assay (elisa) for the detection of igg antibodies against mycobacterium tuberculosis when applied to serum and bronchial washings (bw) of patients requiring bronchoscopy for definitive diagnosis. the elisa employed an adsorbed fraction of mycobacterial sonicates as antigen. of the 57 patients tested, 12 had tuberculosis (tb), 13 had malignant disease, 14 acute pneumonia or chronic destructive pneumonia, 13 had no demonstrable diseas ... | 1988 | 3127124 |
| polyphthienoyl trehalose, glycolipids specific for virulent strains of the tubercle bacillus. | phthienoic acids constitute a family of dextro-rotary odd-numbered unsaturated fatty acids isolated exclusively from virulent strains of human and bovine tubercle bacilli. in the bacterial cell they are not free and a search for their linked form in complex wall lipids of mycobacterium tuberculosis (strain canetti) showed that they esterified trehalose. structural elucidation of the major phthienoyl trehalose showed the occurrence of five acyl residues located at 2, 2', 3', 4 and 6' positions of ... | 1988 | 3127210 |
| the mycobacterial cell-wall as target for antimycobacterial drugs. i--synthesis and activity of some diphenylalkylanalogues of mycolic acids. | mycolic acids are 2-alkyl-3-hydroxyfatty acids and are essential parts of the peptidoglycan of mycobacteria. potential antimetabolites were prepared by substituting a longchain alkylgroup by a diphenylmethylfunction. 3-oxo esters and 3-hydroxy esters and acids were prepared. the 3-oxo esters showed a slight activity against m. tuberculosis and some atypical mycobacteria. | 1987 | 3127238 |
| detection of lytic antimycobacterial antibodies by immune lysis of liposomes sensitized to tuberculin. | two procedures were used in order to incorporate purified protein derivative tuberculin (ppd) from m. tuberculosis, strain h37rv, into calcein-containing liposomes: formation of multilamellar vesicles (mlv) in a ppd solution or exposure of preformed mlv to this solution. immune lysis of these ppd-sensitized mlv was studied in the presence of a hyperimmune anti-m. tuberculosis sheep serum using a specific pathogen-free rabbit serum as a source of complement. a 50% release of encapsulated calcein ... | 1988 | 3127472 |
| susceptibility of micro-organisms to active oxygen species: sensitivity to the xanthine-oxidase-mediated antimicrobial system. | xanthine oxidase with acetaldehyde as substrate (the xoa system) generated superoxide anion and hydrogen peroxide, but this system had only weak bactericidal activity. addition of fe2+ and edta to the xoa system (xoa-fe-edta system) increased bactericidal activity against staphylococcus aureus, escherichia coli, listeria monocytogenes and salmonella typhimurium, although both mycobacterium tuberculosis and candida albicans remained highly resistant. catalase (h2o2 scavenger) and mannitol (.oh sc ... | 1987 | 3127535 |
| relationship between the susceptibility of various bacteria to active oxygen species and to intracellular killing by macrophages. | the susceptibilities of six micro-organisms to active oxygen species generated in the xanthine oxidase-mediated bactericidal system were as follows: escherichia coli 81 greater than or equal to listeria monocytogenes egd greater than or equal to salmonella typhimurium hkb-1 greater than or equal to staphylococcus aureus smith much greater than mycobacterium tuberculosis h37rv approximately equal to candida albicans nih a207 (the last two organisms were essentially resistant to this system). the ... | 1987 | 3127536 |
| [improvement of enzyme-linked immunosorbent assay for the serodiagnosis of active pulmonary tuberculosis]. | | 1987 | 3127623 |
| [short course chemotherapy of tuberculosis]. | | 1987 | 3127624 |
| [improvement of methods of the microbiological diagnosis of tuberculosis]. | | 1987 | 3127821 |
| [use of immunoenzyme assay for the determination of specific antibodies in the prophylactic examination of persons with posttubercular lesions]. | | 1987 | 3127822 |
| excretion of viable tubercle bacilli by blatta orientalis (the oriental cockroach) following ingestion of heat-fixed sputum smears: a laboratory investigation. | adult blatta orientalis were allowed to feed on heat-fixed tuberculous sputum smears and the faeces collected for examination by microscopy and culture. mycobacterium tuberculosis was repeatedly isolated from homogenized faecal pellets using liquid and solid selective culture media. faeces remained positive both microscopically and on culture even after storing for 8 weeks at room temperature. it is recommended that smears, prepared from clinical material which may contain m. tuberculosis or m. ... | 1987 | 3127961 |
| pathological studies on three cases of cancer treated with polysaccharides from human-type mycobacterium tuberculosis. antitumor activity through collagen fiber proliferation. | three cases of cancer treated with ssm (special substance, maruyama: a polysaccharide extract from mycobacterium tuberculosis) for a long period were studied pathologically following biopsies and autopsies. the most significant antitumor activity resulting from ssm treatment was found to be collagenation from stromal cells and the cancer cells themselves. another significant finding was that collagenation was promoted by macrophages which had been stimulated non-specifically. however, it was app ... | 1987 | 3128056 |
| extrapulmonary tuberculosis--a continuing problem in australia. | extrapulmonary tuberculosis (tb) remains a major health problem in australia, with 24.3% of all new tuberculosis notifications in 1984 of extrapulmonary origin. we have reviewed our recent experience to assess the epidemiology and clinical features that may allow the earlier recognition and treatment of patients at risk for this disease. from 1980-1985, 51 cases of extrapulmonary tb were identified at westmead hospital. thirty-eight patients were born outside australia, mainly in south-east asia ... | 1987 | 3128259 |
| proficiency testing of conventional drug susceptibility tests of mycobacterium tuberculosis. | proficiency testing of indirect drug susceptibility tests of mycobacterium tuberculosis was begun in 1985 by the laboratory centre for disease control (lcdc) with the participation of provincial public health laboratories in canada. comparable sets of 60 cultures of mycobacterium tuberculosis representing 30 strains were distributed by lcdc to the participating laboratories to be tested for drug susceptibility against isoniazid, streptomycin, rifampin, and ethambutol using conventional methodolo ... | 1987 | 3128393 |
| biological activity of protein antigens isolated from mycobacterium tuberculosis culture filtrate. | mycobacterium tuberculosis culture filtrate (mtcf) protein antigens were isolated from mid-logarithmic-phase cultures grown in liquid medium and examined by high-pressure liquid chromatography and western blot (immunoblot) analysis. a major protein band with a molecular mass of about 68 kilodaltons (kda) and several fainter bands in the 38- and 24-kda range were observed. the mtcf protein produced a significant delayed footpad hypersensitivity response in mycobacterium bovis bcg-vaccinated c57bl ... | 1988 | 3128483 |
| clofazimine reverses the inhibitory effect of mycobacterium tuberculosis derived factors on phagocyte intracellular killing mechanisms. | the effects of clofazimine on phagocyte functions associated with antimicrobial activity have been investigated. clofazimine at a variety of concentrations was capable of enhancing the spontaneous production of hydrogen peroxide and the intracellular killing ability of phagocytes; but had no effect on resting phagocyte lysozyme release, or hexose monophosphate shunt (hmps) activity. however, when these latter functions were assessed in the presence of a phagocytic stimulus, clofazimine moderatel ... | 1988 | 3128522 |
| [clinical and bacteriological manifestations of nonspecific infection of the urinary tract and dysbacteriosis in patients with tuberculosis of the kidneys]. | altogether 124 patients with tuberculosis of the kidney and post-tuberculous changes of the urinary tracts were investigated. changes in microflora of the urine, feces, blood, fauces, vagina, and resected tissues in the course of antituberculous therapy were studied. frequent disorders in ecological equilibrium of autoflora of the macro-organism were shown to develop in the first 2-4 months of antituberculous therapy, mainly in patients with an active tuberculous process and a complicated course ... | 1987 | 3128884 |
| characteristics and specificity of acquired immunologic memory to mycobacterium tuberculosis infection. | the results herein show that mice infected with mycobacterium tuberculosis and then exposed to a protracted course of isoniazid chemotherapy possess a heightened state of acquired resistance to subsequent challenge with the homologous organism. our results provide the first evidence, moreover, that this resistance is mediated by a long-lived, cyclophosphamide- and irradiation-resistant l3t4+ lyt-2- lymphocyte capable of giving rise to an accelerated re-emergence of resistance in the animal upon ... | 1988 | 3129497 |
| studies on the effect of methotrexate on macrophage function. | time course studies in rat adjuvant arthritis have shown that resident peritoneal macrophages synthesize large amounts of interleukin-1 (il-1) on day 10-11 postadjuvant immunization. expression of ia antigen on these macrophages increased rapidly between day 15 to day 20 postadjuvant treatment and remained at these high levels on day 25. if these adjuvant immunized rats were treated with low doses of methotrexate, resident peritoneal macrophages appeared to synthesize lower amounts of il-1 and t ... | 1988 | 3129560 |
| [course and treatment effectiveness of infiltrative pulmonary tuberculosis in adolescents]. | | 1988 | 3129712 |