| relevance of cardiac parvovirus b19 in myocarditis and dilated cardiomyopathy: review of the literature. | over the last decade, parvovirus b19 (b19v) has frequently been linked to the pathogenesis of myocarditis (mc) and its progression towards dilated cardiomyopathy (dcm). the exact role of the presence of b19v and its load remains controversial, as this virus is also found in the heart of healthy subjects. moreover, the prognostic relevance of b19v prevalence in endomyocardial biopsies still remains unclear. as a result, it is unclear whether the presence of b19v should be treated. this review pro ... | 2016 | 27748022 |
| human parvovirus b19 infection with red cell aplasia and idiopathic thrombocytopenic purpura. | | 2016 | 27727702 |
| detection of parvovirus b19 dna in blood: viruses or dna remnants? | parvovirus b19 (b19v) dna can be detected in blood over a long period after acute infection. several reports associate the presence of b19v dna with disease, irrespective of timing of the initial b19v infection. | 2016 | 27664778 |
| pure red cell aplasia caused by parvovirus b19 in a heart transplant recipient. | a case of parvovirus b19-induced pure red cell aplasia occurring in a heart transplant recipient is reported. the diagnosis of this rare but clinically important complication can be suspected on the basis of the pathognomonic morphological features of the bone marrow. | 2016 | 27648265 |
| persistence of villous immaturity in term deliveries following intrauterine transfusion for parvovirus b19 infection and rhd-associated hemolytic disease of the fetus and newborn. | fetal anemia and hydrops may be caused by parvovirus b19 infection and maternal alloimmunization to rhd with subsequent hemolytic disease of the fetus and newborn. the use of intrauterine transfusion over the last few decades has dramatically improved outcomes. prior literature has extensively documented placental changes associated with untreated parvovirus infection and rhd hdfn in intrauterine fetal demises (iufd) and pre-term births; however, histopathologic changes in term placentas from te ... | 2016 | 27643761 |
| existence of various human parvovirus b19 genotypes in chinese plasma pools: genotype 1, genotype 3, putative intergenotypic recombinant variants and new genotypes. | human parvovirus b19 (b19v) is a frequent contaminant of blood and plasma-derived medicinal products. three distinct genotypes of b19v have been identified. the distribution of the three b19v genotypes has been investigated in various regions or countries. however, in china, data on the existence of different b19v genotypes are limited. | 2016 | 27639978 |
| placental abruption possibly due to parvovirus b19 infection. | there is concern about the development of anemia-associated fetal hydrops associated with maternal parvovirus b19 infection. parvovirus b19 infection occurs via the globoside (p antigen) receptor, the main glycolipid of erythroid cells, which induces apoptosis. similar findings have been reported for the p antigen of globoside-containing placental trophoblast cells. | 2016 | 27547655 |
| parvovirus b19-associated papular-purpuric eruption with atypical localisation: "leg warmer syndrome"? | | 2016 | 27545520 |
| agranulocytosis under biotherapy in rheumatoid arthritis: three cases hypothesis of parvovirus b19 involvement in agranulocytosis observed under tocilizumab and rituximab for the treatment of rheumatoid arthritis. | leukopenia is a considerably common complication of tocilizumab [tcz] and rituximab [rtx] therapy. rtx-induced leukopenia typically exhibits delayed onset. while agranulocytosis has been reported linked to rtx treatment of lymphoma, this complication rarely occurs in rheumatoid arthritis (ra) treatment and, to our knowledge, has never been reported in association with tcz therapy. we herein report four agranulocytosis cases in three patients, with the first two cases suspected to be secondary to ... | 2016 | 27541023 |
| peptide presentation on primate erythroparvovirus 1 virus-like particles: in vitro assembly, stability and immunological properties. | virus-like particles (vlps) have demonstrated to be valuable scaffolds for the display of heterologous peptides for vaccine development and other specific interactions. vlps of primate erythroparvovirus 1, generally referred as parvovirus b19 (b19v), have already been produced in-vivo and in-vitro from the recombinant vp2 protein of this virus. in this study, chimeric forms of b19v vp2 were constructed, and their ability to assemble into vlps was evaluated. chimeras were composed of the vp2 prot ... | 2016 | 27523978 |
| transient red cell aplasia in two brothers with sickle cell anemia and erythrovirus b19 infection. | | 2017 | 27521868 |
| serological prevalence of human parvovirus b19 in diseases or disordersrelated to different human body systems. | human parvovirus b19 is a pathogen that affects different parts of the body. we planned this study because of the lack of data on b19 seroprevalence based on different body-system diseases. | 2016 | 27511498 |
| diagnostic and prognostic value of molecular and serological investigation of human parvovirus b19 infection during pregnancy. | to define diagnostic and prognostic markers of parvovirus b19 (b19v) fetal infection, two groups were investigated: 1) pregnant women with specific symptoms or contacts with symptomatic households (n=37); 2) mothers with pathological ultrasound findings and the relevant fetus at the time of prenatal diagnosis (n=16). in the first group, diagnosis of b19v infection was achieved using igm detection in 29/37 (78.3%) of patients, while b19v dna was detected in 36/37 (97.3%) of infected women. in the ... | 2016 | 27455181 |
| congenital and perinatally-acquired infections in resource-constrained settings. | congenital and perinatal infections are a leading cause of neonatal and infant morbidity and mortality. maternal screening, vaccines or treatment where available, constitute effective prevention strategies to reduce the burden of these diseases. data on the burden of congenital and perinatal infections are very limited for low and middle-income regions. | 2016 | 27442227 |
| atypical rashes in adult human parvovirus b19 infection; atypical is typical. | | 2016 | 27419073 |
| prevalence and viral load of human parvovirus b19 (b19v) among blood donors in south-east brazil. | the infection of human parvovirus b19 (b19v) is a common event in the general population, including volunteer blood donors. in some cases it can be asymptomatic and can remain persistent for a long period of time. the objective of this study was to examine the b19v dna prevalence and viral load in first-time volunteer blood donors. blood samples were collected from 91 primary blood donors at the regional blood center of ribeirão preto, southeast brazil. viral detection and quantitation was perfo ... | 2016 | 27408426 |
| parvovirus b19 passive transmission by transfusion of intercept® blood system-treated platelet concentrate. | pathogen reduction methods for blood components are effective for a large number of viruses though less against small, non-enveloped viruses such as parvovirus b19 (b19v). this article describes the passive transmission by transfusion of two b19v-contaminated pooled platelet concentrates (pcs) which were treated with the intercept® blood pathogen reduction system. | 2016 | 27403092 |
| [seroprevalence of human parvovirus b19 in children with fever and rash in the north of tunisia]. | the aim of the study is to evaluate the prevalence of specific antibodies anti-human parvovirus b19 (pvb19) immunoglobulin m (igm) and igg in children with fever and rash. this study involved 257 children aged from 7 months to 15 years with febrile rash unrelated to measles and rubella (seronegative for igm). the sera were examined by immunoenzymatic assay. detection of antibodies of pvb19 was done by enzyme-linked immunosorbent assay (elisa). in our study, prevalence of immunoglobulin g (igg) a ... | 2016 | 27385036 |
| parvovirus b19. | primary parvovirus b19 infection is an infrequent, but serious and treatable, cause of chronic anemia in immunocompromised hosts. many compromised hosts have preexisting antibody to b19 and are not at risk. however, upon primary infection, some patients may be able to mount a sufficient immune response to terminate active parvovirus b19 infection of erythroid precursors. the most common consequence of b19 infection in the compromised host is pure red-cell aplasia, resulting in chronic or recurre ... | 2016 | 27337440 |
| chronic persistent parvovirus b19 bone marrow infection resulting in transfusion-dependent pure red cell aplasia in multiple myeloma after allogeneic haematopoietic stem cell transplantation and severe graft versus host disease. | we report a chronic persistent parvovirus b19 (pvb19) infection despite long-term immunoglobulin substitution intravenous immunoglobulin (ivig) and tapering of immune-suppressive therapy in a 41-year-old patient after allogeneic haematopoietic stem cell transplantation (allohsct) and long-term immune-suppressive therapy due to a steroid-refractory graft versus host disease (gvhd). | 2017 | 27311084 |
| nonstructural protein (ns1) of human parvovirus b19 stimulates host innate immunity and blunts the exogenous type i interferon signaling in vitro. | b19 virus is a non-enveloped dna virus and belongs to the family of parvoviridae. there are two large open reading frames (orfs), nonstructural protein (ns1) and two capsid proteins (vp1 and vp2). host innate immune responses form the first line of defense against many pathogen invasion. how b19 virus, especially its encoded viral proteins interacts with host innate immune system remains unknown. in this study we aim to investigate the effect of ns1 on the host innate immune response and exogeno ... | 2016 | 27270128 |
| cellulitis-like lesions: an unusual manifestation of a parvovirus b19 infection. | | 2016 | 27266966 |
| hypocomplementemia is a diagnostic clue for parvovirus b19 infection in adults. | | 2017 | 27238731 |
| toxoplasmosis, parvovirus, and cytomegalovirus in pregnancy. | there are several infections in adults that warrant special consideration in pregnant women given the potential fetal consequences. among these are toxoplasmosis, parvovirus b19, and cytomegalovirus. these infections have an important impact on the developing fetus, depending on the timing of infection. this article reviews the modes of transmission as well as maternal and neonatal effects of each of these infections. in addition, the article outlines recommended testing, fetal surveillance, and ... | 2016 | 27235921 |
| parvovirus b19 congenital infection. | | 2016 | 27218697 |
| splenic infarcts as a rare manifestation of parvovirus b19 infection. | human parvovirus b19 is a dna virus most known for causing erythema infectiosum in children, and polyarthropathy or transient aplastic crisis in adults. however, various unusual clinical manifestations have also been reported in association with it. we describe a young patient who presented with splenic infarcts as a rare complication of b19 infection. | 2016 | 27213135 |
| seroprevalence of erythrovirus b19 in saudi pregnant women. | erythrovirus b19 infection is associated with clinical symptoms that range from mild to severe. the common clinical presentation of b19 virus (b19v) infection is erythema infectiosum, arthropathy, aplastic crisis, and fetal infection. infection in seronegative pregnant women can lead to fetal hydrops. | 2017 | 27186157 |
| a false positive dengue fever rapid diagnostic test result in a case of acute parvovirus b19 infection. | an outbreak of dengue fever occurred in japan in august 2014. we herein report the case of a 63-year-old man who presented with a persistent fever in september 2014. acute parvovirus b19 infection led to a false positive finding of dengue fever on a rapid diagnostic test (panbio dengue duo cassette(tm)). to the best of our knowledge, there are no previous reports of a false positive result for dengue igm with the dengue rapid diagnostic test. we believe that epidemiological information on the pr ... | 2016 | 27181552 |
| [a pregnant woman with a red skin and itch]. | a 35-year-old, caucasian multiparous woman presented in the outpatient clinic with an itchy skin rash and arthropathy at 32 weeks gestation. the diagnosis of human parvovirus b19 infection was confirmed by serological tests positive for igg and igm antibodies. parvovirus infection during pregnancy may cause fetal anemia and hydrops fetalis. | 2016 | 27165464 |
| a significantly lower potency observed for the 3rd who international standard for parvovirus b19v dna with the cobas taqscreen dpx test. | in the context of the official medicines control laboratories plasma pool testing for parvovirus b19 dna, we use the cobas taqscreen dpx test. when we re-evaluated this method using the 3rd b19 dna who is at the final concentration of 4 log iu/ml, we observed a titre lower than expected, i.e. 3.79 log iu/ml. therefore, we further investigated the accuracy of the dpx test. | 2016 | 27149002 |
| chimeric external control to quantify cell free dna in plasma samples by real time pcr. | dna isolation procedure can significantly influence the quantification of dna by real time pcr specially when cell free dna (cfdna) is the subject. to assess the extraction efficiency, linearity of the extraction yield, presence of co-purified inhibitors and to avoid problems with fragment size relevant to cfdna, development of appropriate external dna control (edc) is challenging. using non-human chimeric nucleotide sequences, an edc was developed for standardization of qpcr for monitoring stab ... | 2017 | 27141267 |
| focal epilepsy as a long term sequela of parvovirus b19 encephalitis. | human parvovirus b19 (pvb19), the etiological agent of the fifth disease, is associated with a large spectrum of pathologies, among which is encephalitis. since it has been detected from the central nervous system in children or in immunocompromised patients, its causative role in serious neurological manifestations is still unclear. here we report the case of an 18-year-old healthy boy who developed encephalitis complicated by prolonged status epilepticus. the detection of pvb19 dna in his seru ... | 2016 | 27130981 |
| genotype 3b of human parvovirus b19 detected from hospitalized children with solid malignancies in a north indian tertiary care hospital. | human parvovirus b19 (b19v) infection is known to cause serious consequences in immuno-compromized individuals. the present cross sectional study was designed to estimate the prevalence and genotype distribution of b19v in children receiving chemotherapy for solid malignancies at a tertiary care hospital in north india during october 2013 to may 2015. serum samples from all the patients were tested for anti-b19v igm and igg antibodies and for b19v-dna as soon as received. samples testing positiv ... | 2016 | 27116539 |
| betaferon in chronic viral cardiomyopathy (bicc) trial: effects of interferon-β treatment in patients with chronic viral cardiomyopathy. | chronic viral infections of the heart are considered one antecedent event leading to progressive dysfunction of the myocardium, often with an impaired prognosis due to a virus- or immune-mediated myocardial injury. symptomatic treatment does not influence the viral cause of heart failure, and the effect of antiviral treatment has not been determined, yet. | 2016 | 27112783 |
| parvovirus b19 induced lupus-like syndrome with nephritis. | we report a case of a 65-year-old man who developed an acute illness with fever, arthralgia and nephritic syndrome. antinuclear antibodies were slightly positive and complement levels were low. renal biopsy showed exudative diffuse proliferative endocapillary glomerulonephritis with diffuse immunoglobulin (igg, iga, igm) and complement deposition (c3d, c4d, c1q) on immunofluorescence. the patient was first treated with corticosteroids and mycophenolate mofetil for suspected lupus with who class ... | 2016 | 27075795 |
| enhanced inhibition of parvovirus b19 replication by cidofovir in extendedly exposed erythroid progenitor cells. | human parvovirus b19 (b19v) commonly induces self-limiting infections but can also cause severe clinical manifestations in patients with underlying haematological disorders or with immune system deficits. currently, therapeutic options for b19v entirely rely on symptomatic and supportive treatments since a specific antiviral therapy is not yet available. recently a first step in the research for active compounds inhibiting b19v replication has allowed identifying the acyclic nucleoside phosphona ... | 2016 | 27071853 |
| ana testing in the presence of acute and chronic infections. | autoantibody testing is performed to help diagnose patients who have clinical symptoms suggestive of possible autoimmune diseases. antinuclear antibodies (ana) are present in many systemic autoimmune conditions such as systemic lupus erythematosus (sle). however, a positive ana test may also be seen with non-autoimmune inflammatory diseases, including both acute and chronic infections. when the ana test is used as an initial screen in patients with non-specific clinical symptoms, such as fever, ... | 2016 | 27050929 |
| the impact of specific viruses on clinical outcome in children presenting with acute heart failure. | the presence and type of viral genomes have been suggested as the main etiology for inflammatory dilated cardiomyopathy. information on the clinical implication of this finding in a large population of children is lacking. we evaluated the prevalence, type, and clinical impact of specific viral genomes in endomyocardial biopsies (emb) collected between 2001 and 2013 among 63 children admitted to our hospital for acute heart failure (median age 2.8 years). viral genome was searched by polymerase ... | 2016 | 27043551 |
| autoimmune hemolytic anemia triggered by infection with human parvovirus b19 after total abdominal colectomy for ulcerative colitis. | a 50-year-old man was admitted to our hospital for an adhesive ileus 14 years after total abdominal colectomy for ulcerative colitis (uc). the ileus decreased with conservative treatment, however, autoimmune hemolytic anemia (aiha) was diagnosed due to worsening anemia, a positive direct coombs test, low haptoglobin, high lactase dehydrogenase, reticulocytosis, and an increase in the erythroblastic series in a bone-marrow examination. human parvovirus b19 (pv-b19) igm and pv-b19 dna were present ... | 2016 | 26984090 |
| prevalence of a positive torch and parvovirus b19 screening in pregnancies complicated by polyhydramnios. | the aim of this study was to evaluate the rate of women with polyhydramnios who eventually screened positive to infectious disease by serum screening testing for torch and parvovirus b19. | 2016 | 26970557 |
| human parvovirus b19-induced transient red cell aplasia in a patient with vitamin b12 deficiency. | | 2016 | 26970225 |
| severe anemia due to parvovirus b19 in a silver haired boy. | griscelli syndrome (gs) is a rare autosomal recessive immunodeficiency disorder in which the affected children present with characteristic silvery-white hairs. the hair microscopy of these children is characteristic and is helpful in differentiating gs from chediak-higashi syndrome which also presents with immunodeficiency and silver hairs. we report a 17-month-old boy with gs type 2 who presented with severe anemia. bone marrow examination of the child suggested parvovirus b19 as the cause of s ... | 2017 | 26960654 |
| original research: parvovirus b19 infection in children with sickle cell disease in the hydroxyurea era. | parvovirus b19 infection causes transient aplastic crisis in sickle cell disease (scd) due to a temporary interruption in the red blood cell production. toxicity from hydroxyurea includes anemia and reticulocytopenia, both of which also occur during a transient aplastic crisis event. hydroxyurea inhibits proliferation of hematopoietic cells and may be immunosuppressive. we postulated that hydroxyurea could exacerbate parvovirus b19-induced aplastic crisis and inhibit the development of specific ... | 2016 | 26940953 |
| the receptor-binding domain in the vp1u region of parvovirus b19. | parvovirus b19 (b19v) is known as the human pathogen causing the mild childhood disease erythema infectiosum. b19v shows an extraordinary narrow tissue tropism for erythroid progenitor cells in the bone marrow, which is determined by a highly restricted uptake. we have previously shown that the specific internalization is mediated by the interaction of the viral protein 1 unique region (vp1u) with a yet unknown cellular receptor. to locate the receptor-binding domain (rbd) within the vp1u, we an ... | 2016 | 26927158 |
| enhanced assembly and colloidal stabilization of primate erythroparvovirus 1 virus-like particles for improved surface engineering. | virus-like particles (vlps) are the product of the self-assembly, either in vivo or in vitro, of structural components of viral capsids. these particles are excellent scaffolds for surface display of biomolecules that can be used in vaccine development and tissue-specific drug delivery. surface engineering of vlps requires structural stability and chemical reactivity. herein, we report the enhanced assembly, colloidal stabilization and fluorescent labeling of primate erythroparvovirus 1 (pe1v), ... | 2016 | 26911883 |
| [bicytopenia due to parvovirus b19 infection in octogenarian: a case report]. | | 2016 | 26888340 |
| clinicopathological associations of acquired erythroblastopenia. | acquired erythroblastopenia (ae) is a rare clinical situation. it is characterized by the reduction of erythroid precursors in the bone marrow together with the low reticulocyte counts in the peripheral blood. | 2015 | 26885236 |
| novel col4a1 mutation in an infant with severe dysmorphic syndrome with schizencephaly, periventricular calcifications, and cataract resembling congenital infection. | a clinical case is described of growth retardation, severe developmental delay, facial dysmorphic features with microcephaly, as well as congenital cataract, schizencephaly, periventricular calcifications, and epilepsy. | 2016 | 26879631 |
| possible involvement of mirnas in tropism of parvovirus b19. | human parvovirus b19 (pvb19) is one of the most important pathogens that targets erythroid lineage. many factors were mentioned for restriction to erythroid progenitor cells (epcs). previous studies showed that in non-permissive cells vp1 and vp2 (structural proteins) mrnas were detected but could not translate to proteins. a bioinformatics study showed that this inhibition might be due to specific micrornas (mirnas) present in non-permissive cells but not in permissive epcs. to confirm the hypo ... | 2016 | 26878856 |
| detection of parvovirus b19 infection in thalasemic patients in isfahan province, iran. | parvovirus b19, a member of the erythrovirus genus of parvoviridae family, causes various clinical illnesses including infectious erythema, arthropathy, hydrops fetalis or congenital anemia, and transient aplastic crises. the b19 virus can be transmitted through respiratory secretions, blood products, and blood transfusion. | 2015 | 26855745 |
| insights into epidemiology of human parvovirus b19 and detection of an unusual genotype 2 variant, bulgaria, 2004 to 2013. | the present study aimed to determine the role of human parvovirus в19 (b19v) as an aetiological agent in measles and rubella negative fever/rash patients from bulgaria between 2004 and 2013. a total of 1,266 sera from all over the country were tested for b19v igm antibodies and all positives were further investigated by polymerase chain reaction (pcr). overall, 280 sera (22%) were b19v igm positive and 227 of these (81%) were also pcr positive. the highest number of igm positives was found among ... | 2016 | 26847955 |
| parvovirus b19 replication and expression in differentiating erythroid progenitor cells. | the pathogenic parvovirus b19 (b19v) is characterized by a strict adaptation to erythroid progenitor cells (epcs), a heterogeneous population of differentiating cells with diverse phenotypic and functional properties. in our work, we studied the dynamics of b19v infection in epcs in dependence on the cell differentiation stage, in terms of distribution of infected cells, synthesis of viral nucleic acids and production of infectious virus. epcs at early differentiation stage led to an abortive in ... | 2016 | 26845771 |
| postinfectious glomerulonephritis secondary to erythrovirus b19 (parvovirus b19): case report and review of the literature. | a previously healthy 32-yearold woman developed arterial hypertension, proteinuria, and hematuria (nephritic syndrome) with normal renal function and was diagnosed with post-infectious glomerulonephritis secondary to parvovirus b19 infection. the renal biopsy showed endocapillary glomerulonephritis, with positive igg, c3, and c1q immunoreactivity in the capillary walls and ultrastructural evidence of subendothelial deposits. the diagnosis of parvovirus b19 infection was confirmed by igg/igm sero ... | 2016 | 26833301 |
| outbreak of parvovirus b19 infection among anesthesiology and surgical fellows. | a human parvovirus b19 outbreak was detected in personnel assigned to a surgical area (anesthesiology fellows and an otorhinolaryngology fellow) in a university hospital. the attack rate between susceptible members was higher than previous reports. diagnosis was determined by polymerase chain reaction for human parvovirus b19 in serum of 1 subject and immunoglobulin m/immunoglobulin g antibody titer in the remaining subjects. medical personnel were put on leave of absence until resolution of sym ... | 2016 | 26831272 |
| mutational characteristics of ank1 and sptb genes in hereditary spherocytosis. | the aim of this study was to describe the mutational characteristics in korean hereditary spherocytosis (hs) patients. relevant literatures including genetically confirmed cases with well-documented clinical summaries and relevant information were also reviewed to investigate the mutational gene- or domain-specific laboratory and clinical association. twenty-five hs patients carried one heterozygous mutation of ank1 (n = 13) or sptb (n = 12) but not in spta1, slc4a1, or epb42. deleterious mutati ... | 2016 | 26830532 |
| [diagnostic value of combined use of combined method of enzyme immunoassay and polymerase chain reaction to detect of intrauterine fetal infection by parvovirus b19]. | the combined method of diagnosis parvovirus infection during pregnancy by maternal serum enzyme immunoassay and deoxyribonucleic acid isolation parvovirus b19 polymerase chain reaction in amnniotic fluid and fetal cord blood newborns, can diagnose vertical transmission and anticipate a negative effect on the fetus parvovirus. lack of maternal igm antibodies in serum due to parvovirus seroconversion during pregnancy does not exclude the persistence of the virus in the fetus. to analyze the diagno ... | 2016 | 26827452 |
| carbimazole-induced agranulocytosis. | a 47 year old lady with hyperthyroidism for past 1½ years was initially on carbimazole 20 mg orally then changed to 30 mg (during hysterectomy) but was taking 10 mg for last 1 year. she had intermittent fever with severe b/l bifrontal headache since 3 weeks. routine investigations showed anaemia, neutropenia, leucopenia and crp elevation. peripheral smear showed normocytic normochromic anaemia with rouleaux formation, leucopenia with 2% atypical cells and mild thrombocytosis. widal test, ra fact ... | 2017 | 26813922 |
| parvovirus leading to thrombotic microangiopathy in a healthy adult. | a healthy 47-year-old man initially presented with symptoms of body rash, myalgias, dark urine, nausea and vomiting. acute kidney injury, and positive urine analysis for blood and protein warranted a kidney biopsy, which revealed micro thrombi in kidney vasculature, suggestive of thrombotic microangiopathy. serology revealed positive parvovirus b19 igm antibodies and biopsy tests revealed a viral genome on pcr. despite plasma exchanges and treatment with rituximab, renal function continued to de ... | 2016 | 26811413 |
| pseudo-erysipelas: a new atypical cutaneous manifestation of parvovirus b19 primary infection. | | 2016 | 26791960 |
| clinical profile of patients with advanced age and inflammatoric dilated cardiomyopathy on endomyocardial biopsy. | endomyocardial biopsy (emb) is an important tool when patients with inflammatoric cardiomyopathy (dcmi) are evaluated. we aimed to assess the clinical profile of elderly patients with dcmi on emb. | 2015 | 26788036 |
| hepatic inflammation resulting from localized, subcutaneous expression of parvovirus vp1u capsid protein: importance and implication. | | 2016 | 26786960 |
| update of the human parvovirus b19 biology. | since its discovery, the human parvovirus b19 (b19v) has been associated with many clinical situations in addition to the prototype clinical manifestations, i.e. erythema infectiosum and erythroblastopenia crisis. the clinical significance of the viral b19v dna persistence in sera after acute infection remains largely unknown. such data may constitute a new clinical entity and is discussed in this manuscript. in 2002, despite the genetic diversity among b19v viruses has been reported to be very ... | 2016 | 26778837 |
| isolated hypoplasia of abdominal wall muscles associated with fetal ascites. | we report the case of an infant born after parvovirus b19-induced fetal hydrops, who presented at birth with bilateral abdominal wall laxity, which was more evident on the flanks. imaging exams revealed congenital hypoplasia of oblique abdominal muscles not associated with other anatomical abnormalities except for small liver calcifications. we review the medical literature and identify similar cases associated with fetal ascites. we propose that isolated hypoplasia of abdominal wall muscles can ... | 2016 | 26762954 |
| identification of recombination in the ns1 and vps genes of parvovirus b19. | human parvovirus b19 (b19v), a member of the genus erythrovirus of the family parvoviridae, is a pathogenic virus distributed worldwide in the human population. in this study, we performed phylogenetic and recombination analysis of b19v based on the available nonstructural gene (ns1) and capsid proteins (vps) genes in genbank. results indicated that recombination occurred between genotypes 3 and 1, leading to the recombinant cluster genotype 2. other three inter-genotype recombination events wer ... | 2016 | 26756922 |
| femoral agminated petechiae associated with acute parvovirus b19 infection. | | 2016 | 26756269 |
| steroid-responsive status epilepticus caused by human parvovirus b19 encephalitis. | | 2016 | 26756268 |
| microsphere-based antibody assays for human parvovirus b19v, cmv and t. gondii. | human parvovirus b19 (b19v), cytomegalovirus (cmv) and toxoplasma gondii (t. gondii) may cause intrauterine infections with potentially severe consequences to the fetus. current serodiagnosis of these infections is based on detection of antibodies most often by eia and individually for each pathogen. we developed singleplex and multiplex microsphere-based suspension immuno assays (sias) for the simultaneous detection of igg antibodies against b19v, cmv and t. gondii. | 2016 | 26746194 |
| [the comparative benchmark analysis of the methods used to verify etiology of myocarditis associated with alcoholic cardiomyopathy]. | immunohistochemical (ihc) methods and polymerase chain reaction (pcr) were employed to study the cases of death from alcoholic cardiomyopathy (acmp) among the patients presenting with interstitial myocarditis who did not have this condition in their medical histories. ihc studies revealed the expression of anti-parvovirus b19 antibodies in cardiomyocytes (cmc) and inflammatory infiltrate cells of 40% of the patients. these antibodies were expressed in vascular smooth cells and inflammatory infil ... | 2015 | 26710509 |
| focal seizure associated with human parvovirus b19 infection in a non-encephalopathic child. | the incidence of acute symptomatic (at the time of documented brain insult) seizures and single unprovoked seizures are 29-39 and 23-61 per 100 000 per year, respectively. after stabilization of the patient, finding the etiology of the seizure is of paramount importance. a careful history and physical examination may allow a diagnosis without need for further evaluation. | 2016 | 26684306 |
| [autoimmune lymphoproliferative syndrome: a case report and literature review]. | we described 1 case of autoimmune lymphoproliferative syndrome (alps), first diagnosed in our hospital, and reviewed the recent literature. the 11-month old male patient presented with a history of splenomegaly and hepatomegaly since 1 month after birth. he suffered recurrent infectious diseases including cytomegalovirus infection, parvovirus b19 infection and chronic diarrhea disease. besides, his symptoms included hemolytic anemia and thrombocytopenia. the laboratory abnormality indicated an e ... | 2015 | 26679669 |
| human parvovirus b19 and low hemoglobin levels in pregnant sudanese women. | to investigate risk factors for, and the seroprevalence of, parvovirus b19 (b19v), as well as the effect of b19v infection on patient hemoglobin levels. | 2016 | 26674318 |
| acute parvovirus b19 infection detected in bone marrow biopsy. | | 2015 | 26668860 |
| complexity in interpreting partial viral sequence data as supportive evidence for possible transfusion transmitted parvovirus b19 infection. | | 2016 | 26646810 |
| the role of parvovirus b19 in the pathogenesis of autoimmunity and autoimmune disease. | human parvovirus b19 is a single-stranded dna virus which preferentially targets the erythroblasts in the bone marrow. b19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. b19 infection has also been associate ... | 2016 | 26644521 |
| human parvovirus b19 vp1u protein as inflammatory mediators induces liver injury in naïve mice. | human parvovirus b19 (b19v) is a human pathogen known to be associated with many non-erythroid diseases, including hepatitis. although b19v vp1-unique region (b19-vp1u) has crucial roles in the pathogenesis of b19v infection, the influence of b19-vp1u proteins on hepatic injury is still obscure. this study investigated the effect and possible inflammatory signaling of b19-vp1u in livers from balb/c mice that were subcutaneously inoculated with vp1u-expressing cos-7 cells. the in vivo effects of ... | 2016 | 26632342 |
| parvovirus b19 myocarditis in children: an observational study. | the advent of pcr testing for the presence of viral genomes has led to the identification of parvovirus b19 (pvb19) as a causative agent of myocarditis. | 2016 | 26613943 |
| bones hold the key to dna virus history and epidemiology. | dna in human skeletal remains represents an important historical source of host genomic information and potentially of infecting viruses. however, little is known about viral persistence in bone. we searched ca. 70-year-old long bones of putative finnish casualties from world war ii for parvovirus b19 (b19v) dna, and found a remarkable prevalence of 45%. the viral sequences were exclusively of genotypes 2 (n = 41), which disappeared from circulation in 1970´s, or genotype 3 (n = 2), which has ne ... | 2015 | 26611279 |
| aplastic crisis secondary to parvovirus b19 infection as the first manifestation of an undiagnosed hereditary spherocytosis: report of a pediatric series of spanish patients. | | 2016 | 26583618 |
| acute encephalitis and encephalopathy associated with human parvovirus b19 infection in children. | reports of neurologic manifestations of human parvovirus b19 (b19) infection have been on the rise. acute encephalitis and encephalopathy is the most common, accounting for 38.8% of total b19-associated neurological manifestations. to date, 34 children with b19 encephalitis and encephalopathy have been reported, which includes 21 encephalitis and 13 encephalopathy cases. ten (29%) were immunocompromised and 17 (39%) had underlying diseases. fever at the onset of disease and rash presented in 44. ... | 2015 | 26566485 |
| characterization of markers of the progression of human parvovirus b19 infection in virus dna-positive plasma samples. | accurate characterization of the infection stage in parvovirus b19(b19v)-positive plasma donations would help establish the donation deferral period to contribute to a safe fractionation pool of plasma. | 2015 | 26557815 |
| confirmation of etiology in fetal hydrops by sonographic evaluation of fluid allocation patterns. | to evaluate patterns of fluid allocations in different etiologies of hydrops fetalis. | 2015 | 26540593 |
| no definite association between human parvovirus b19 infection and behçet disease. | the etiology of the behçet disease (bd) has remained obscured. there have been studies to show the association of bd to infections like herpes simplex, hepatitis, and parvovirus b19 however, the findings are rather controversial. | 2015 | 26538777 |
| prevalence and genotypic characterization of human parvovirus b19 in children with measles- and rubella-like illness in iran. | human parvovirus b19 (b19v) is a prototype of the erythroparvovirus genus in parvoviridae family. b19v infections are often associated with fever and rash, and can be mistakenly reported as measles or rubella. differential diagnosis of b19v illness is necessary for case management and also for public health control activities, particularly in outbreak situations in which measles or rubella is suspected. to investigate the causative role of b19v infection in children with measles- and rubella-lik ... | 2016 | 26538067 |
| up-regulation of epithelial na(+) channel enac by human parvovirus b19 capsid protein vp1. | clinical disorders caused by parvovirus b19 (b19v) infection include endothelial dysfunction with cardiac ischemia. the virus is effective in part by lysophosphatidylcholine-producing phospholipase a2 (pla2) activity of b19v capsid protein vp1. mechanisms compromising endothelial function include up-regulation of amiloride sensitive epithelial na(+)-channel enac leading to endothelial cell stiffness. regulators of enac include ubiquitin-ligase nedd4-2. the present study explored whether vp1 modi ... | 2016 | 26522226 |
| seroprevalence of parvovirus b19 antibodies among young pregnant women or planning pregnancy, tested for toxoplasmosis. | acute parvovirus b19 (b19v) infection is a proven risk for pregnant women and fetus. the aim of this study was to determine the prevalence of b19v antibodies among pregnant women or planning pregnancy, who were referred for preventive toxoplasmosis screening. | 2015 | 26519843 |
| blood donors screening for blood born viruses in poland. | blood donor screening of viral markers in poland is based on serologic testing for anti-hcv, hbsag, anti-hiv1/2 (chemiluminescence tests) and on nucleic acid testing (nat) for rna hcv, rna hiv-1 and dna hbv performed in minipools of 6 with real-time pcr (mpx 2.0 test on cobas s201) or with tma in individual donations (ultrio plus or ultrio elite). donors of plasma for anti-d and anti-hbs production are tested for parvovirus b19 dna. before implementation tests and equipment are evaluated at the ... | 2015 | 26519842 |
| parvovirus b19 1a complete genome from a fatal case in brazil. | parvovirus b19 (b19v) infects individuals worldwide and is associated with an ample range of pathologies and clinical manifestations. b19v is classified into three distinct genotypes, all identified in brazil. here, we report a complete sequence of a b19v genotype 1a that was obtained by high-throughput metagenomic sequencing. this genome provides information that will contribute to the studies on b19v epidemiology and evolution. | 2015 | 26517666 |
| parvovirus b19 infection presenting as acute hepatitis and transient anemia in a previously healthy child. | acute hepatitis has been noted as a manifestation of parvovirus b19 infection in children and adults, although its pathogenesis remains unclear. in this report, we present a case of an 11-year old thai boy with parvovirus b19-associated acute hepatitis who presented with jaundice, hepatomegaly and transient aplastic crisis. our report underscores the need to consider parvovirus b19 as the causative pathogen in patients with increased liver enzymes, jaundice and anemia. | 2015 | 26513925 |
| prdm1 expression via human parvovirus b19 infection plays a role in the pathogenesis of hashimoto thyroiditis. | ectopic lymphoid follicle infiltration is a key event in hashimoto thyroiditis (ht). positive regulatory domain zinc finger protein 1 (prdm1), which is induced by antigen stimulation, can regulate all lymphocyte lineages. several groups independently demonstrated that human parvovirus b19 (pvb19) is closely associated with ht. hence, we determined whether prdm1 is expressed in ht thyroid tissue and whether there is any correlation between prdm1 expression and pvb19 in the pathogenesis of ht. we ... | 2015 | 26475096 |
| recurrent pure red cell aplasia in a hepatorenal transplant recipient with chronic parvovirus b19 infection. | | 2016 | 26457576 |
| parvovirus b19-associated microvesicular eruption. | we report on a 3-year-old girl with a microvesicular generalized rash in whom primary infection by parvovirus b19 was demonstrated by seroconversion. to our knowledge, this is the first instance of an eruption arising from parvovirus b19 with this peculiar clinical pattern. | 2015 | 26447144 |
| prevalence of human parvovirus b19 in chinese plasma pools for manufacturing plasma derivatives. | human parvovirus b19 (b19v) is a frequent contaminant of blood and plasma-derived medicinal products. to ensure the quality and safety of plasma-derived products, european regulations, plasma protein therapeutics association (ppta) standard and fda guidelines require testing of manufacturing plasma for parvovirus b19 dna to limit the load of this virus. in china, however, there have been no related documentation and technical guiding principles for monitoring b19v, moreover, an adequate level of ... | 2015 | 26445095 |
| human parvovirus b19 and autoimmune diseases. review of the literature and pathophysiological hypotheses. | a number of arguments support the role played by pvb19 in autoimmunity, in the broad sense of the term essentially derived from numerous clinical case reports and/or small series over the past 20-30 years in the medical literature. pvb19 can induce a very broad spectrum of autoantibody production, especially including: anti-soluble nuclear antigen antibodies, antiphospholipid antibodies anti-native dna antibodies, antilymphocyte antibody, anticardiolipin antibodies, antinuclear antibodies and rh ... | 2015 | 26433772 |
| parvovirus b19-induced acute bilateral carpal tunnel syndrome in twin girls. | we describe 2 cases of 6-year-old twin girls presenting with acute carpal tunnel syndrome (cts) associated with human parvovirus b19 (hpv-b19) infection, as evidenced by serological data and detection of hpv-b19 dna in blood with use of polymerase chain reaction (pcr). to our knowledge, this is the first time that hpv-b19 infection has been suggested as the causal agent of simultaneous acute bilateral cts in twins, thus presenting the possibility that similar immunologic responses can be observe ... | 2015 | 26422355 |
| persistent and prolonged parvovirus b19 viremia in a pediatric patient with acute lymphoblastic leukemia. | parvovirus b19 is a small single-stranded dna virus of the parvoviridae family. depending on host factors, it may produce a wide array of clinical disease states. disease severity can range from self-limited to severe, requiring significant supportive care. immunocompromised patients are generally affected more severely but rarely develop prolonged and persistent infections. here, we describe a patient who was diagnosed with parvovirus during maintenance therapy for acute lymphoblastic leukemia ... | 2015 | 26407441 |
| atypical exanthems associated with parvovirus b19 infection: similarities and differences between adults and children. | | 2015 | 26397302 |
| hereditary spherocytosis unmasked by human parvovirus b19 induced aplastic crisis in a family. | human parvovirus (hpv) b19 induced aplastic crisis in a family leading to the diagnosis of hereditary spherocytosis (hs) is a very rare condition being barely reported in the literature. we herein report a 4-year-old girl, her brother, and their mother who all presented with progressive pallor and jaundice after a febrile illness. the hpv b19 was diagnosed using polymerase chain reaction (pcr) and positive serology for specific anti-hpv b19 igm. they were further diagnosed with having hs. the cl ... | 2015 | 26379354 |
| pericardial effusion and adenosine deaminase false positivity due to parvovirus b19. | this case is presented to highlight that one of the causes for massive exudative pericardial effusion in a child may be parvovirus b19, and adenosine deaminase can be falsely positive in such patients. | 2015 | 26376310 |
| prevalence and incidence of erythrovirus b19 infection in children with sickle cell disease: the impact of viral infection in acute clinical events. | b19v infection is common during childhood. it is self-limited in healthy individuals, but is often associated with transient aplastic crisis in children with sickle cell disease. the aim of this study was to estimate the prevalence and incidence of b19v infection in children with sickle cell disease screened by the newborn screening program of minas gerais, brazil, and followed-up at fundação hemominas. serum or plasma samples from 278 patients were tested for anti-b19v igg and igm using commerc ... | 2016 | 26369294 |
| [serological diagnosis of congenital infections and algorithms to improve diagnostic efficacy]. | congenital infection is those transmitted by the mother to the fetus before delivery. it can occur transplacentally or by direct contact with the pathogen during birth or in the immediate postnatal period. congenital infection can be due to viruses (rubella, cytomegalovirus, herpes simplex, varicella-zoster, hepatitis b and c virus, human inunodeficiencia, erythrovirus b19) as bacteria (treponema pallidum) and parasites (toxoplasma gondii and trypanosoma cruzi). serological diagnosis of congenit ... | 2015 | 26320992 |