| genes for the major protein antigens of mycobacterium tuberculosis: the etiologic agents of tuberculosis and leprosy share an immunodominant antigen. | mycobacterium tuberculosis genes encoding immunologically relevant proteins were isolated by systematically screening a lambda gt11 recombinant dna expression library with a collection of murine monoclonal antibodies directed against protein antigens of this pathogen. these antibodies, previously characterized by a world health organization workshop on monoclonal antibodies against mycobacteria, were used to isolate dna sequences encoding five major protein antigens of this pathogen. to evaluate ... | 1987 | 3104901 |
| [classification of mycobacterium tuberculosis by phage typing markers in the city of havana province]. | | 1986 | 3105006 |
| [bacteriology of tuberculosis]. | | 1986 | 3105080 |
| [theoretical basis for the treatment of tuberculosis]. | | 1986 | 3105082 |
| [physiopathology of tuberculosis]. | | 1986 | 3105083 |
| [incidence of primary and secondary resistance of m. tuberculosis in east germany in 1983 in hospitalized patients]. | the frequency of primary drug resistance in patients treated in hospital because of tuberculosis of the lung in 1983 was 2.3% (21 patients). among them there were 5 patients (0.6%) with resistance to both inh and sm and 1 patient with a fourfold resistance. the frequency of secondary drug resistance was 20% (29 patients), among them a good third showed resistance to two or more drugs. comparing to 1980 a decrease by half of patients treated repeatedly and also of the number of patients with seco ... | 1986 | 3105189 |
| the antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria. | the aim of the present investigation was to illustrate the antibacterial effect of various phenothiazine and thioxanthene derivatives on mycobacteria in vitro. it was demonstrated that clopenthixol is about twice as potent as chlorpromazine (cpz) and levomepromazine-maleate is about half as potent as cpz, measured by the inhibitory effect on the growth of the mycobacterial strains. measured in the same way the stereoisomeric compounds of flupenthixol are shown to be more potent than the stereo-i ... | 1986 | 3105243 |
| in vitro susceptibility of mycobacterium tuberculosis, mycobacterium africanum, mycobacterium bovis, mycobacterium avium, mycobacterium fortuitum, and mycobacterium chelonae to ticarcillin in combination with clavulanic acid. | the in vitro susceptibility of mycobacterium tuberculosis, mycobacterium bovis, mycobacterium africanum, mycobacterium avium, mycobacterium fortuitum, and mycobacterium chelonae (m. chelonei) to ticarcillin in combination with calvulanic acid (ca) was studied by the agar dilution method. all the m. tuberculosis, m. bovis, and m. africanum strains were inhibited at a ticarcillin concentration of 32 micrograms/ml or lower in combination with 5 micrograms of ca. m. chelonae and m. avium strains pro ... | 1987 | 3105441 |
| periodic acid in the staining of acid-fast bacilli in tissue section. | | 1987 | 3105515 |
| endobronchial tuberculosis. serial fiberoptic bronchoscopy and natural history. | endobronchial tuberculosis in the preantibiotic era was considered a complication of advanced post-primary disease. bronchial mucosa adjacent to parenchymal cavities was bathed in infectious sputum, resulting in implantation. effective antituberculosis drug therapy has reduced childhood exposure, resulting in an increase in adult primary tuberculosis with unusual clinical and roentgenographic presentations. we studied four adults with endobronchial tuberculosis who presented with unusual lobe in ... | 1987 | 3105965 |
| enumeration of t cells reactive with mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kda protein. | the major goal of the present study was to develop a limiting dilution system for the enumeration of t cells which respond to mycobacterial antigens. purified t cells from m. tuberculosis-immune mice were restimulated with mycobacterial antigens and accessory cells, and after 4 days expanded with antigen, accessory cells and t cell growth factor. after another 3 days, proliferative responses were determined. similar cultures performed without antigen served as controls. limiting dilution analysi ... | 1987 | 3106059 |
| t-cell activation by anti-idiotypic antibody: evidence for the internal image. | human lymphoproliferative responses to a rabbit anti-idiotypic antibody (anti-id tb71) and the corresponding mycobacterial protein antigen [38,000 molecular weight (mw)] have been investigated in a number of donors. it was found that responsiveness to anti-id tb71 correlated with responder and non-responder (four subjects each) status to the 38,000 mw antigen. furthermore, the induction of t-cell proliferation by both the 38,000 mw antigen and the anti-id tb71 was dependent on accessory cells. w ... | 1987 | 3106197 |
| structural requirements of muramylpeptides for induction of necrosis at sites primed with mycobacterium tuberculosis in guinea pigs. | intracutaneous injection of n-acetylmuramyl-l-alanyl-d-isoglutamine (mdp) in guinea pigs caused an extensive necrotic reaction in footpads prepared by injection of heat-killed mycobacterium tuberculosis in water-in-mineral-oil emulsion. we examined a variety of analogs and derivatives of muramylpeptides for their ability to provoke this reaction. a maximum and a minimum structure responsible for the necrotic reaction were found to be n-acetylglycosaminyl-beta(1-4)-n-acetylmuramyl-tripeptide (glc ... | 1987 | 3106217 |
| screening of a recombinant mycobacterial dna library with polyclonal antiserum and molecular weight analysis of expressed antigens. | a lambda gt11 expression library containing recombinant dna from mycobacterium tuberculosis was screened using hyperimmune anti-m. tuberculosis rabbit serum. the majority (22 of 29) of the recombinant clones selected by using polyclonal serum expressed three antigens that were previously identified by using mouse monoclonal antibodies, thus indicating the immunodominance of these proteins. western blot analysis of the recombinant clones demonstrated that expression of these antigens is frequentl ... | 1987 | 3106221 |
| [the assessment of pleural biopsy culture in the diagnosis of tuberculous pleurisy]. | | 1987 | 3106561 |
| elisa using mycobacterial antigens as a diagnostic aid for tuberculous meningitis. | an enzyme-linked immunosorbent assay (elisa) was studied as a possible laboratory test to aid in the diagnosis of tuberculous meningitis (tbm) in an indian population. the assay detected mycobacterial antibodies in the cerebrospinal fluid (csf) of tbm patients. three antigens, ppd, bcg and m. tuberculosis were tested for use in the assay and of these, m. tuberculosis was found to be the most suited. a sensitivity of 72% and specificity of 92% with m. tuberculosis as antigen was obtained for the ... | 1987 | 3106582 |
| characteristics of human t-cell clones from bcg and killed m. leprae vaccinated subjects and tuberculosis patients. recognition of recombinant mycobacterial antigens. | | 1986 | 3106732 |
| peptides as potential immunodiagnostic reagents to detect mycobacterial infections. | | 1986 | 3106733 |
| analysis of a leprosy-specific antibody epitope. | | 1986 | 3106734 |
| immunogenic synthetic peptides against mycobacteria of potential immunodiagnostic and immunoprophylactic value. | | 1986 | 3106735 |
| [immunologic method of predicting the tuberculosis process]. | | 1987 | 3106953 |
| [nutrient media for cultivating mycobacterium tuberculosis]. | | 1987 | 3106954 |
| [potentiating the specific activity of isoniazid and streptomycin by benzimidazole derivatives]. | | 1987 | 3106955 |
| [the effect of nucleic acids and their precursors on the growth of mycobacterium tuberculosis h37ra and bcg]. | | 1986 | 3107218 |
| [detection of mycobacteria in tissue in urogenital tuberculosis]. | 121 tissue specimens of the urogenital systems (66 from the kidney, 39 from the epididymis and testis, 8 from the prostate, 4 from the bladder and 4 from the female genital tract) were examined by microscopy, culture and animal experiment on the presence of mycobacteria. in 37 of these specimens (30.6%) mycobacteria were demonstrated, 10 of that only by microscopy and in 27 cases by culture and/or animal experiment. up to 20 weeks after onset of treatment mycobacteria were demonstrated from the ... | 1986 | 3107253 |
| activity of ciprofloxacin and other fluorinated quinolones against mycobacteria. | the new fluorinated quinolones display interesting but variable activity against mycobacteria. almost all compounds tested (ciprofloxacin, ofloxacin, enoxacin, norfloxacin, difloxacin, ci-934, a-56620, and megalone) inhibit mycobacterium tuberculosis at achievable serum concentrations, with ciprofloxacin and ofloxacin most active by weight (minimal inhibitory concentration at which growth of 90 percent of strains is inhibited is equal to 1 microgram/ml or less). the growth of mycobacterium kansa ... | 1987 | 3107379 |
| [smear-positive and culture-negative results in detecting acid-fast bacilli in the sputum and their clinical significance]. | | 1986 | 3107941 |
| mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of mycobacterium tuberculosis. | growth inhibition of the intracellular bacterial pathogens mycobacterium bovis and m. tuberculosis by lymphokine-activated murine bone marrow macrophages was studied. mycobacterial growth was assessed by the uptake of 3h-uracil or by determination of colony-forming units. stimulation of macrophages with recombinant interferon-gamma (r-ifn-gamma) or with ifn-gamma-containing supernatants from antigen- or mitogen-stimulated t cells markedly reduced growth of m. bovis strain bcg phipps or m. tuberc ... | 1987 | 3108389 |
| immunology of tuberculosis: new directions in research. | tuberculosis is still one of the major health problems in almost all over the world. thus, new directions in basic and applied research on tuberculosis are under investigation. in this review we have provided recent data obtained in our laboratories on three main aspects of the immunology of tuberculosis, namely: i. the role of b lymphocytes in the processing and presentation of mycobacterium tuberculosis antigens to t cells; ii. the activation and characterization of mycobacterial-specific t ce ... | 1987 | 3109004 |
| enzyme-linked immunosorbent assay for the detection of mycobacterial antigens in the cerebrospinal fluid in tuberculous meningitis. | fifty-three cerebrospinal fluid specimens from meningitis patients were investigated by enzyme-linked immunosorbent assay for detection of mycobacterial antigens. after heating at 56 degrees c for 1 hour to eliminate nonspecific interference, all 22 tuberculous meningitis (tbm) specimens had an optical density of greater than 0.05 (sensitivity 100%). six out of 31 non-tbm cases gave false-positive results (specificity 81%). | 1987 | 3109040 |
| drug resistance in mycobacterium tuberculosis: a survey over 25 years in blackburn. | over the past 25 years the incidence of tuberculosis in blackburn has changed from one that was below the national average to one which is consistently in the 10 highest local authority areas in england and wales. a survey of primary and acquired drug resistance over the same period included 974 ethnic white patients and 538 of indian subcontinent ethnic origin. primary drug resistance in the white population has fallen consistently from 1965 onwards and is now zero. only one case of acquired re ... | 1986 | 3109053 |
| effect of cord factor, a toxic glycolipid from mycobacterium tuberculosis, on mouse liver drug metabolizing enzymes. | cord factor (a mycobacterial toxin) treatment of mice for 72 hr resulted in decreased activities of hepatic drug metabolizing enzymes. the toxin treated animals exhibited reduced levels of liver cytochrome p-450 and cytochrome b5, accompanied by significant lowering of nadph-cytochrome c reductase and nadh-cytochrome b5 reductase activities. the hepatic activities of aminopyrine n-demethylase and aniline hydroxylase were diminished, while liver cytosolic glutathione s-transferase activity was in ... | 1987 | 3109076 |
| drug-resistant tuberculosis in a southern california hospital. trends from 1969 to 1984. | resistance to one or more antituberculosis drugs was found in 98 of 281 (35%) patients hospitalized at harbor-ucla with culture-positive tuberculosis between 1980 and 1984. resistance to antituberculosis drugs occurred in 23% of patients who had not been previously treated, whereas previously treated patients had a 59% rate of resistance. the overall rates of drug resistance had not significantly changed from prior studies at this hospital. drug resistance was also found in patients with extrapu ... | 1987 | 3109291 |
| inner-city survey for tuberculosis: evaluation of diagnostic methods. | a total of 1,271 persons living in a socially and economically depressed, inner-city area of vancouver, british columbia, voluntarily attended a tuberculosis case-finding campaign. chest x-ray, on-the-spot specimen of sputum, and tuberculin skin test were offered at the time of the first attendance. all 3 diagnostic methods were found to be well accepted, with 93% of the participants having an x-ray, over 95% producing a sputum specimen, and almost 95% having a tuberculin test (a quarter of thes ... | 1987 | 3109292 |
| management of tuberculous pericarditis. | the cases of 17 patients with tuberculous pericarditis were reviewed. thirteen patients had effusive pericarditis, and 10 had surgical drainage of the effusion. no deaths were due to pericardial tamponade; this appears to be related to earlier recognition of major pericardial effusions by echocardiography. in 2 patients clinical evidence of pericardial constriction developed while they were on a regimen of therapy, and in another 2 patients, echocardiography revealed pericardial thickening after ... | 1987 | 3109338 |
| sensitivity to rifaximin and rifampicin of mycobacterium tuberculosis isolated from guinea pigs treated orally with rifaximin. | the in vitro sensitivity of the h 37 rv strain of mycobacterium tuberculosis to rifaximin and rifampicin was determined by evaluating both the antimycobacterial activity of the two rifamycin derivatives after oral administration to infected guinea pigs and the influence of rifaximin on the susceptibility to rifampicin of the isolated strain from spleen, lungs and liver. the results showed that after oral treatment with rifaximin no changes regarding the sensitivity of the strain to rifaximin and ... | 1987 | 3109750 |
| various strains of bcg vaccine and genetic control of the immune response of mice. | numerous field trials of bcg vaccine, undertaken to evaluate its effectiveness in the prophylaxis of human tuberculosis, indicated that the levels of protection achieved were not uniform. most probable factors influencing these results are: partial protection due to atypical mycobacteria, tuberculosis expectancy in different population, nutritional and socio-economic factors, potency of bcg vaccines, and genetic factors controlling the host immune response. specific and non specific hallmarks of ... | 1986 | 3109987 |
| histopathological and bacteriological status of quiescent cases of pulmonary tuberculosis. | | 1986 | 3110056 |
| serology of tuberculosis. | | 1986 | 3110058 |
| total hip arthroplasty for tuberculous coxarthrosis. | forty-four total hip prostheses were implanted in thirty-eight patients who had tuberculous arthritis of the hip. the interval between active disease and total hip arthroplasty ranged from three months to forty-five years. the length of follow-up averaged 45.6 months (range, twenty-four to eighty-five months). cultures of material and specimens of tissue that were taken intraoperatively were positive in four hips. the mean functional rating of the hip was 62 points preoperatively and 85 points a ... | 1987 | 3110167 |
| six cases of mycobacterium tuberculosis bacteremia. | | 1987 | 3110309 |
| [relation between antibody formation and drug resistance of mycobacterium tuberculosis]. | | 1987 | 3110763 |
| [immunological indices of patients with destructive pulmonary tuberculosis due to bovine and human mycobacterium tuberculosis]. | | 1987 | 3110764 |
| [significance of different mycobacterium species in the epidemiology of tuberculosis]. | | 1987 | 3110765 |
| [characteristics of a mycobacterium population growing in pulmonary tuberculomas]. | | 1987 | 3110766 |
| [detection of pulmonary tuberculosis in adolescents in institutions of the general medical network and efficacy of its treatment]. | altogether 100 adolescents with tb detected on referral to general medical institutions were followed up. 30 patients with a clear-cut tb clinicoroentgenological pictures were referred to special hospitals. the rest 70 adolescents were followed up in general outpatients departments. the chief method of prehospital diagnosis verification was inefficacy of previous antiinflammatory therapy. 51 patients were not examined for tuberculosis (tuberculin test, chest x-ray, sputum investigation for tuber ... | 1987 | 3110991 |
| pulmonary cytology in tuberculosis. | a review was made of 138 sputa, 4 bronchial washings and 4 bronchial aspirates from 64 patients with pulmonary tuberculosis. the cytologic findings that may indicate granulomatous involvement were epithelioid cells, giant cells, lymphocytes and a necrotic background. cell-block preparations stained by the ziehl-neelsen technique gave a positivity for acid-fast bacilli similar to that of bacterioscopy. this study emphasizes the potential diagnostic value of inflammatory alterations, even when the ... | 1987 | 3111136 |
| [growth-promoting effects of histamine on mycobacterium tuberculosis]. | | 1987 | 3111445 |
| significance of the tuberculin test in the elderly. | nine hundred thirty-three persons over 65 years of age, residing in long-term or extended-care facilities in vancouver, canada, had tuberculin tests. in addition to ppd-tuberculin, 5 tu and 250 tu, we used ppd-battey, candida albicans, mumps, and trichophyton antigens. twenty-five percent reacted to 5 tu of tuberculin with reactions of 10 mm or more. there was a progressive, substantial loss of reactivity with advancing age. reactions to ppd-battey greater than to ppd-t 5 tu were infrequent, sug ... | 1987 | 3111795 |
| comparison of two modified sauton media for tuberculin production. | | 1986 | 3111902 |
| production and purification of eta (eta) precipitinogen, species-specific to mycobacterium tuberculosis and its intradermal reactivity. | the partially purified preparation of eta precipitinogen which is species-specific for mycobacterium tuberculosis showed skin reaction specificity for guinea pigs sensitized with m. tuberculosis. strains of m. tuberculosis and the conditions for cultivation for optimal production of stable eta precipitinogen preparation in a large scale were investigated. additional purification of procedures of the partially purified preparation of eta were also investigated. the significance of eta precipitino ... | 1986 | 3111903 |
| comparative study of biological potencies of different tuberculins. | | 1986 | 3111904 |
| comparative testing of the potency of different ppd preparations. | the potency of different ppd preparations, obtained from m. tuberculosis and m. bovis was investigated in the guinea-pig test. the groups of animals were immunized with dried mycobacterium powder (obtained from m. tuberculosis, m. bovis and m. tuberculosis + m. bovis), suspended in sterile liquid paraffin oil and with bcg vaccine. the potency tests were carried out according to the who requirements. independently of the immunization method, a significantly greater potency of homologous versus he ... | 1986 | 3111905 |
| sensitivity to avian sensitin of tuberculin reactors in belgium. | it was proposed that a study should be made on the specificity of the reactions of 1068 subjects reacting "weakly to moderately" to an intradermal test with 2 units of ppd rt23; 43% were classified as "positives" (greater than or equal to 10 mm) and palmer type iv indurations or merely erythema were seen in 81%. three months later, the same people were retested, this time with 2 units of ppd rt23 and, simultaneously, with 0.1 mcg of avian sensitin: 23% of all reactors (13% of all "positives", bu ... | 1986 | 3111906 |
| the significance of a dual skin test with ppd and ppd-b in humans after bcg vaccination. | dual skin tests with tuberculin purified protein derivative (ppd) and with one of the following antigens prepared from mycobacteria other than m. tuberculosis, such as ppd-y, ppd-g, ppd-b, ppd-f, etc., are performed to establish the frequency of "atypical" mycobacterial infection in a given population. however, most of this work has been done in areas where bcg vaccination was rarely implemented, if at all. the purpose of this study was to assess the significance of a dual skin test using ppd an ... | 1986 | 3111907 |
| response to tuberculin ppds prepared from m. tuberculosis and other mycobacteria in a 1 to 16 year old population. | | 1986 | 3111908 |
| response of inbred mice to aerosol challenge with mycobacterium tuberculosis. | an autosomal dominant gene (bcg), which maps to mouse chromosome 1, has been shown to confer on mice resistance to attenuated mycobacterium bovis bcg montreal, salmonella typhimurium, and leishmania donovani. most animal models used for the study of the bcg gene have involved intravenous injection of a large number of microorganisms (greater than 10(4) cfu). the present study examines the effect of the bcg gene on the resistance of inbred mice to challenge via the respiratory route with 5 to 10 ... | 1987 | 3112014 |
| comparative in-vitro activity of five fluoroquinolones against mycobacteria. | fifty distinct strains of mycobacteria were investigated to determine their in-vitro susceptibility to five new fluoroquinolones (norfloxacin, pefloxacin, ofloxacin, enoxacin and ciprofloxacin). ofloxacin and ciprofloxacin were found to be the most active, with minimum inhibitory concentrations (mic) of 1.25 mg/l or less to all strains of mycobacterium tuberculosis, m. bovis, m. xenopi, m. kansasii and bcg tested. all agents showed little activity against m. malmoense and m. avium-intracellulare ... | 1987 | 3112094 |
| in-vitro activity of six fluorinated quinolones against mycobacterium tuberculosis. | thirty-five clinical isolates of mycobacterium tuberculosis, 24 susceptible and 11 resistant to conventional primary antituberculous drugs, were tested against six new quinolones. the mode mics of isoniazid susceptible organisms on 7h11 agar for ciprofloxacin, ofloxacin, enoxacin, norfloxacin, ci-934 and a56620 were 1.0, 1.0, 2.0, 2.0, 1.0 and 1.0 mg/l, respectively. strains resistant to isoniazid and other antituberculous agents were usually inhibited within one dilution of these values. these ... | 1987 | 3112095 |
| activity of ciprofloxacin against mycobacteria in vitro: comparison of bactec and macrobroth dilution methods. | various clinical isolates of mycobacteria were tested for susceptibility to ciprofloxacin by a standard macrobroth dilution test and the radiometric bactec method. agreement between the two test systems was species dependent: mycobacterium tuberculosis (80%), m. kansasii with m. scrofulaceum (30%), m. avium-intracellulare (20%), and 0% for the rapidly growing mycobacteria. most mycobacterial strains other than m. tuberculosis were susceptible to the breakpoint ciprofloxacin concentration of 2 mg ... | 1987 | 3112096 |
| expression of proteins of mycobacterium tuberculosis in escherichia coli and potential of recombinant genes and proteins for development of diagnostic reagents. | recombinant plasmids containing dna from mycobacterium tuberculosis were transformed into escherichia coli, and three colonies were selected by their reactivity with polyclonal antisera to m. tuberculosis. the three recombinant vectors contained dna inserts of different sizes flanking a common 4.7-kilobase (kb) sequence. each recombinant produced 35- and 53-kilodalton proteins (35k and 53k proteins, respectively) which were absent in the control e. coli. in western blotting experiments, both pro ... | 1987 | 3112175 |
| whole chromosomal dna probes for rapid identification of mycobacterium tuberculosis and mycobacterium avium complex. | whole chromosomal dna probes were used to identify clinical isolates of mycobacterium tuberculosis, mycobacterium avium complex, and mycobacterium gordonae. the probe for m. tuberculosis was prepared from mycobacterium bovis bcg, which has been shown to be closely related to m. tuberculosis. a probe for the m. avium complex was prepared from three strains representing each of the three dna homology groups in the m. avium complex. the probes were used in dot blot assays to identify clinical isola ... | 1987 | 3112180 |
| primary resistance to antituberculous drugs in a new jersey hospital. | | 1987 | 3112660 |
| [studies with the bactec 460 system. 2. isolation of mycobacterium tuberculosis from the sputum. comparison of the radiometric with the conventional method]. | | 1987 | 3112760 |
| [early diagnosis of tuberculous eye diseases]. | | 1987 | 3112766 |
| [drug resistance of mycobacterium tuberculosis]. | | 1987 | 3113076 |
| [the problem of a combination of tuberculosis and alcoholism]. | | 1987 | 3113134 |
| a study of mycobacterium tuberculosis antigen and antibody in cerebrospinal fluid and blood in tuberculous meningitis. | radioimmunoassay (ria) techniques have been evaluated to detect specific tubercular antigen (tb ag) and antitubercular antibody (tb ab) in csf and serum of patients with tuberculous meningitis (tbm). a solid-phase ria using h37rv sonicate antigen of mycobacterium tuberculosis, anti-bcg antibody, and staphylococcal protein a was standardized. tb ag and tb ab levels were noted to be significantly elevated in cerebrospinal fluid (csf) as well in circulating immune complexes (cic) isolated from seru ... | 1987 | 3113789 |
| [preliminary study on the detection of tuberculosis antibodies in ascites with enzyme-linked immunosorbent]. | | 1987 | 3113855 |
| [prospective study on the preliminary evaluation of a tuberculosis susceptibility test with the micro-culture dish method using native products]. | | 1987 | 3113894 |
| structure of the major triglycosyl phenol-phthiocerol of mycobacterium tuberculosis (strain canetti). | phenol-phthiocerol glycolipids have been found previously in mycobacterium leprae, m. kansasii, m. bovis and m. marinum, but not in m. tuberculosis. a search for glycolipids in this latter species showed that the canetti strains of m. tuberculosis synthesize a major triglycosyl phenol-phthiocerol, accompanied by minor amounts of other glycolipids with a similar aglycone moiety. the triglycoside moiety has the following structure: 2,3,4-tri-o-methyl l-fucopyranosyl(alpha 1----3)l-rhamnopyranosyl( ... | 1987 | 3113946 |
| impaired resistance to mycobacterium tuberculosis infection after selective in vivo depletion of l3t4+ and lyt-2+ t cells. | the resistance of mice against mycobacterium tuberculosis infection after selective in vivo depletion of l3t4+ and lyt-2+ t cells was studied. thymectomized mice were treated with rat monoclonal antibodies against the l3t4 or lyt-2 molecule to selectively eliminate the respective t-cell subset. in both l3t4+ and lyt-2+ t-cell-depleted mice, resistance against subsequent infection with m. tuberculosis was markedly impaired compared with that in untreated controls, with l3t4+ t-cell-depleted mice ... | 1987 | 3114143 |
| in vivo and in vitro characterization of murine t-cell clones reactive to mycobacterium tuberculosis. | seventeen helper t-cell clones were derived by stimulating lymph node cells from sensitized c57bl/6 mice with mycobacterium tuberculosis h37ra, m. tuberculosis h37rv, or purified protein derivative. most clones cross-reacted with mycobacterium bovis bcg, h37ra, h37rv, and purified protein derivative. however, four clones were able to differentiate h37rv from h37ra, or bcg from h37ra and h37rv. in addition, four other t-cell clones recognized recombinant antigens of 19 and 65 kilodaltons isolated ... | 1987 | 3114149 |
| rapid identification of mycobacterium avium complex in culture using dna probes. | a commercial dna probe procedure for identification of mycobacterium avium complex isolates was evaluated for accuracy and applicability for use in the clinical laboratory. the test (gen-probe rapid diagnostic system for mycobacterium avium complex; gen-probe corp., san diego, calif.) uses hybridization in solution of two 125i-labeled cdna probes. one probe is complementary to rrna from m. avium, and the other is complementary to rrna from m. intracellulare. results are expressed as absolute per ... | 1987 | 3114319 |
| low serum antimycobacterial glycolipid antibody titers in the sera of patients with systemic lupus erythematosus associated with central nervous system involvement. | antibodies which bind to glycolipids derived from mycobacterium tuberculosis were sought in the sera of patients with systemic lupus erythematosus (sle), with and without neurological disease, patients with active tuberculosis and normal controls. a significantly lower activity against the mycobacterial glycolipids was detected in the sera of patients with sle with neurological involvement compared to other patients with sle or controls. we suggest that low antibody levels against mycobacterial ... | 1987 | 3114486 |
| [in vitro and in vivo activities of norfloxacin, ofloxacin and ciprofloxacin against various mycobacteria]. | | 1987 | 3114537 |
| [the diagnosis of tuberculosis]. | | 1986 | 3114588 |
| response to tuberculin ppds prepared from mycobacterium tuberculosis and other mycobacteria in children of buenos aires. | | 1986 | 3114591 |
| [characteristics of osteoarticular tuberculosis caused by various species and l forms of mycobacteria]. | | 1987 | 3114737 |
| [interrelations between cellular reactions and the bacterioscopic picture in pulmonary tuberculosis during chemotherapy]. | | 1987 | 3114738 |
| radiometric studies of mycobacterium tuberculosis. | | 1987 | 3114862 |
| [comparative effectiveness of different methods for the microbiological study of resected pulmonary tuberculomas]. | wide-range microbiological study (bacterioscopy, inoculation, biological assays) of 114 lung tuberculomas excised from 107 patients has revealed a pronounced variability and sharply decreased viability of mycobacterial populations vegetating in caseous foci. differences in the frequency and character of the detection of mycobacterium tuberculosis and their altered forms, arising from the use of three above-mentioned methods of microbiological investigation, were noted. bacterioscopy proved to be ... | 1987 | 3115013 |
| igg antibody level to mycobacterial glycoprotein in pulmonary tuberculosis by elisa. | sera from patients with active pulmonary tuberculosis and sera from appropriate control individuals were assayed for igg, iga and igm antibodies against glycoprotein from tubercle bacilli by an enzyme-linked immunosorbent assay. the mean antibody levels in igg and iga were significantly higher in the tuberculosis patients than in the controls. by measuring igg antibody, this assay may provide a diagnostic tool to distinguish patients with active pulmonary tuberculosis from patients with other pu ... | 1987 | 3115808 |
| isoniazid and ethambutol as a cause of optic neuropathy. | a well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked. a patient developed optic neuropathy while being treated with isoniazid and ethambutol. the optic neuropathy subsided only when both drugs were discontinued, suggesting an additive toxic effect. | 1987 | 3115809 |
| mycobacterial carbohydrate antigens for serological testing of patients with leprosy. | to determine whether quantitation of antibodies to mycobacterial carbohydrate determinants would be valuable in serodiagnosis and monitoring of leprosy, we tested serum igm antibody to mycobacterium leprae phenolic glycolipid i and igm and igg antibodies to mycobacterium tuberculosis and m. leprae lipoarabinomannan (lam) by enzyme-linked immunosorbent assay. seventy-one percent of patients with paucibacillary disease and 85.5% of patients with multibacillary disease were positive for at least on ... | 1987 | 3116103 |
| metabolic studies on mycobacteria. iv. assay of isocitrate lyase and malate synthase activity in m. leprae. | cell free extracts from m. tuberculosis h37 rv, m. smegmatis armadillo derived m. leprae and normal armadillo liver homogenates were assayed for the presence of isocitrate lyase and malate synthase activity. it was observed that significant amount of isocitrate lyase and malate synthase activity was present in m. tuberculosis h37 rv, m. smegmatis and armadillo derived m. leprae. no such activity was demonstrable in cell free extracts of normal armadillo liver. it is concluded that m. leprae like ... | 1987 | 3116105 |
| effects of mitomycin c on m. tuberculosis. | | 1987 | 3116134 |
| [a comparative study of the susceptibilities to antituberculosis agents between mycobacterium tuberculosis and mycobacterium avium complex strains]. | | 1987 | 3116312 |
| [value of the germ-carrier method for testing of the activity of disinfectants against mycobacteria strains]. | we investigated bactericidal activity of four disinfectants against mycobacterium smegmatis and others mycobacteria species such as those responsible for respiratory and lymphadenitis diseases. we used the germ carried method according to all the afnor requisites changing only the strains culture conditions and for some studies time of contact (15 and 30 minutes). in addition we realized a preliminary essay to control efficacy of washing in order to maximally eliminate the product after the time ... | 1987 | 3116490 |
| [chemotherapy of tuberculosis]. | | 1987 | 3116507 |
| [characteristics of destructive pulmonary tuberculosis detected by various methods]. | | 1987 | 3116539 |
| [effectiveness of single and fractional administration of isoniazid in the treatment of dogs infected with isoniazid-resistant strains of mycobacterium tuberculosis]. | | 1987 | 3116540 |
| virulence of tubercle bacilli isolated from patients with tuberculosis in bangalore, india. | this is a study of the virulence of cultures of mycobacterium tuberculosis isolated from pulmonary and extrapulmonary forms of tuberculosis in patients living in or near bangalore, india. the findings are as follows: 1. the percentage of cultures recovered from cases of pulmonary tuberculosis in bangalore classified as being of low, moderate, and high virulence, was the same as that reported by mitchison et al., in 1960 for isolates obtained from patients in madras, india. 2. the distribution of ... | 1986 | 3116728 |
| inhibition of virulent mycobacterium tuberculosis by murine peritoneal macrophages and human alveolar lavage cells: the effects of lymphokines and recombinant gamma interferon. | both murine peritoneal macrophages and human alveolar lavage cells inhibited growth of m. tuberculosis in a medium containing 10% foetal calf serum. however, whereas addition of recombinant gamma interferon or crude lymphokine reproducibly activated further strong anti-mycobacterial mechanisms in the murine cells, these stimuli had weak and variable effects on human alveolar cells. | 1986 | 3116729 |
| national survey of tuberculosis notifications in england and wales in 1983: characteristics of disease. report from the medical research council tuberculosis and chest diseases unit. | the number of newly notified, previously untreated patients in a survey of notifications of tuberculosis in england and wales conducted by the mrc in 1983 was 26% lower than in the previous mrc survey in 1978/79. in both surveys the great majority of patients were of white (about half) or indian subcontinent (indian, pakistani or bangladeshi) ethnic origin (just over a third). the notification rates in the indian subcontinent (isc) ethnic groups were much higher than for the white group and were ... | 1987 | 3116730 |
| virulence for guinea pigs of tubercle bacilli isolated from the sputum of participants in the bcg trial, chingleput district, south india. | this study, conducted in madras, india and in madison, wisconsin, usa, was concerned with the virulence of isolates of mycobacterium tuberculosis obtained from the sputum of individuals living in the chingleput district of south india. the following results were obtained. 1. the findings of mitchison with respect to the predominance of low virulence for guinea pigs among isolates from persons living madras, were confirmed on isolates from the sputum of residents of the chingleput district. 2. a ... | 1987 | 3116731 |
| the inoculation of tissue specimens into guinea-pigs in suspected cases of mycobacterial infection--does it aid diagnosis and treatment? | the record of guinea-pig inoculations carried out at the london hospital during a 5-year period was examined. a total of 677 specimens were inoculated into guinea-pigs: 34 were positive on culture and guinea-pig post-mortem and 22 were positive on culture alone. only five were positive on guinea-pig post-mortem when culture was negative and in only three of these five cases were mycobacteria isolated from the guinea-pig tissues. all three cases had been diagnosed effectively on histological grou ... | 1987 | 3116732 |
| in vitro properties of rifapentine (mdl473) relevant to its use in intermittent chemotherapy of tuberculosis. | in a comparison of in vitro properties of rifapentine (rif) and rifampicin (rmp), the minimal inhibitory concentration of rif against mycobacterium tuberculosis in tween-albumin liquid medium was usually 0.02 micrograms/ml, 2-3 times lower than for rmp; the bactericidal activity against a log phase culture was slightly less than that of rmp and the recovery after pulsed exposures to 1 microgram/ml of rif or rmp lasting 6, 24 and 96 h was identical for the two rifamycins. these findings are used ... | 1987 | 3116733 |
| in vitro susceptibility of mycobacterium tuberculosis to a new macrolide antibiotic: ru-28965. | the in vitro susceptibility of mycobacterium tuberculosis to a new macrolide antibiotic ru-28965, alone and in combination with rifampicin or isoniazid, was studied by the agar dilution method. at a concentration of 4 mg/l, or lower, of ru-28965, 90% of the strains were inhibited. a synergistic effect with both rifampicin and with isoniazid was demonstrated. | 1987 | 3116734 |
| is the tuberculosis screening program of hospital employees still required? | the american thoracic society and the centers for disease control recommend that each hospital has a tuberculosis screening program. as the incidence of active tuberculosis in the united states has been decreasing during the last 30 yr, the necessity for continuing this screening program may be questioned. this prospective study evaluates whether screening hospital employees is still useful. in the state of washington from january 1, 1982, through december 31, 1984, tuberculosis was diagnosed in ... | 1987 | 3116895 |