| [preliminary observation on the detection of tubercle antibodies in the micro-serum of auricular lobulus by elisa]. | | 1986 | 3091334 |
| the role of i-region associated antigen (ia)-bearing accessory cells in the generation of cytotoxic t cells in a subpopulation of thymocytes. | the roles of killer-helper factor (khf) and accessory cells bearing i-region associated antigen (ia) in the generation of cytotoxic t lymphocytes (ctl) were analyzed. peanut agglutinin-binding (pna+) thymocytes from c3h/hen mice generated efficient ctl responses against 2,4,6-trinitrophenyl (tnp)-modified syngeneic spleen cells in the presence of cell-free supernatant (cfs) derived from purified protein derivatives (ppd)-stimulated mycobacterium tuberculosis-primed balb/c spleen cell culture (pp ... | 1986 | 3091558 |
| structure and antigenicity of the phosphorylated lipopolysaccharide antigens from the leprosy and tubercle bacilli. | a family of major arabinose- and mannose-containing phosphorylated lipopolysaccharides was isolated from mycobacterium leprae and mycobacterium tuberculosis. the only antigenic member of the family, lipoarabinomannan (lam)-b, was purified by anion exchange and gel filtration chromatography in detergent and recovered in large quantities (15 mg/g of bacteria). it yielded a broad diffuse band on polyacrylamide gel electrophoresis but appeared homogeneous by this criterion and gel filtration. beside ... | 1986 | 3091602 |
| an assessment of the enzyme-linked immunosorbent assay (elisa) for diagnosis of pulmonary tuberculosis. | | 1986 | 3091747 |
| [characteristics of morphological changes in the lungs of guinea pigs after administration of ultra-small forms of mycobacteria obtained from patients with tuberculosis]. | | 1986 | 3092208 |
| [comparative therapeutic activity of rifampicin and isoniazid in different densities of microbial population in the lungs of experimental animals]. | | 1986 | 3092209 |
| [effect of streptococcal and staphylococcal infections on the course of experimental tuberculosis]. | | 1986 | 3092210 |
| [a standardized highly sensitive variant of the complement fixation test for the detection of anti-tuberculosis antibodies]. | | 1986 | 3092211 |
| elusive diagnosis of tuberculous peritonitis. | four patients with tuberculous peritonitis were diagnosed at our hospital in one year. in two patients it was only after surgery for iatrogenic bowel perforation that the diagnosis was made. the difficulty in recognizing this illness in those patients prompted a review of cases in arkansas over the past nine years. a total of 27 cases have been documented; in 14 the diagnosis was made after considerable delay or during surgery for another diagnosis. tuberculous peritonitis should be considered i ... | 1986 | 3092366 |
| [method for improving the diagnostic animal study in the detection of mycobacterial]. | in 5,400 animal tests of different specimens for detection of mycobacteria the spleen of the guinea pigs was checked for mycobacteria by microscopy and culture also after macroscopic negative results. on this way the number of positive results of animal tests could be increased by 22.6%. | 1986 | 3092478 |
| [a clinical observation on urogenital tuberculosis]. | a clinical observation was made on 30 cases of urogenital tuberculosis diagnosed and treated at the urological department of our hospital between january, 1976 and december, 1984. furthermore, 20 of them were examined for drug resistance and investigated for this tendency. they accounted for 0.23% of the outpatients. male to female ratio was 2 to 1, but on urological tuberculosis this ratio was even. the average age was 43.7 and 50% of the patients who had a history of tuberculosis. mycobacteriu ... | 1986 | 3092603 |
| primary drug-resistant tuberculosis in children. emergence of primary drug-resistant strains of m. tuberculosis to rifampin. | a prospective study of primary drug-resistant strains of mycobacterium tuberculosis among children was begun at the kings county hospital medical center of brooklyn in 1961 and reported at 5 4-yr periods through 1980. the present report extends our observations of primary drug-resistant tuberculosis in children through 1984. the salient finding in the present report was the increase in primary drug resistance to rifampin, 3 of 19 strains resistant in the last period of study (1981 to 1984) as co ... | 1986 | 3092708 |
| in vitro susceptibility of mycobacterium tuberculosis, mycobacterium fortuitum and mycobacterium chelonei to augmentin. | | 1986 | 3093225 |
| kinetics of the tuberculocidal response by alkaline glutaraldehyde in solution and on an inert surface. | single cell suspensions of bcg and mycobacterium tuberculosis were exposed to 2% alkaline glutaraldehyde solution (ph 8.0) and the rate of kill measured at intervals up to 30 min. residual glutaraldehyde was neutralized with freshly prepared 1% sodium bisulphite. the rate of kill was directly proportional to the temperature and independent of the inoculum size whether the organism was tested in suspension or attached to an inert surface. glutaraldehyde was slightly more bactericidal for the viru ... | 1986 | 3093441 |
| beta-lactam antibiotics and mycobacteria. | | 1986 | 3093446 |
| comparison in sensitized and unsensitized guinea-pigs of tuberculin ppds rt 23 and ppd-m by skin tests and lymphocyte stimulation tests. effect of immunization time. | the biological activities of tuberculin ppd rt 23 and the international standard for purified protein derivative of mammalian tuberculin (ppd-m) were compared in sensitized and unsensitized guinea-pigs by skin tests and lymphocyte stimulation (ls) tests. estimates of relative potency (rp) from skin test results were dependent on the dose level, on the immunogen used, and, in guinea-pigs immunized with killed tubercle bacilli in oil, also on the immunization time. relative potency estimates from ... | 1986 | 3093484 |
| an evaluation of the polyacrylamide gel electrophoresis fractionation method for the production of mycobacterium tuberculosis skin test preparations. i. production, physiochemical characterization and serological analyses. | as a part of a cooperative inter-laboratory who supported project raw tuberculins were produced and purified protein derivative (ppd, 18.7 g protein) was prepared. employing a multistage preparative polyacrylamide gel electrophoresis (page) method the ppd was separated into four fractions corresponding to 15, 7, 4.75 and 3.5% gel concentrations. the page procedure resulted in three lots of material--each representing 11 electrophoretic runs. immunodiffusion analyses showed that the largest numbe ... | 1986 | 3093486 |
| an evaluation of the polyacrylamide gel electrophoresis fractionation method for the production of mycobacterium tuberculosis skin test preparations. ii. comparative skin testing on guinea-pigs. | as part of a cooperative inter-laboratory who supported project for the fractionation of mycobacterium tuberculosis skin test preparations, four fractions (designated 15, 7, 4.75 and 3.5%) were evaluated by comparative skin tests on sensitized guinea-pigs. the 7% fraction was the most potent in both homologously and heterologously sensitized animals, and the 4.75% and 3.5% gel fractions showed the lowest activity. significant levels of cross-reactivity in guinea-pigs immunized with m. bovis bcg, ... | 1986 | 3093487 |
| effects of therapeutic dosage of gamma ray on the drug susceptibility of mycobacteria. | | 1986 | 3093622 |
| [application of middlebrook 7h-10 agar medium for rapid detection of mycobacteria]. | | 1986 | 3093736 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 40-1986. a 28-year-old cambodian immigrant woman with recent fever and abdominal distention. | | 1986 | 3093860 |
| [significance of tuberculous infection in pediatric practice and borderline conditions in pediatric nephrology]. | | 1986 | 3093971 |
| synthesis and some reactions of 2-cyanomethylimidazo [4,5-b]pyridine. tuberculostatic investigations of obtained compounds. | 2-cyanomethylimidazo [4,5-b]pyridine 1 was obtained and its properties during acid and basic hydrolysis, esterification, and reaction with hydrogen sulfide were investigated. condensation of 1 with aromatic aldehydes was also studied. some of the obtained compounds were tested on tuberculostatic activity. | 1986 | 3093995 |
| [clinical and bacteriological aspects of the drug resistance of mycobacterium tuberculosis in patients with chronic destructive pulmonary tuberculosis]. | | 1986 | 3094001 |
| [effectiveness of the method of electrophoretic concentration of mycobacteria]. | | 1986 | 3094002 |
| [biological properties of drug-sensitive mycobacterium tuberculosis]. | | 1986 | 3094003 |
| tuberculosis screening in boston's homeless shelters. | from february 1984, through march 1985, a total of 26 cases of tuberculosis (tb) were verified in homeless persons in boston. fifteen cases were resistant to isoniazid (inh) and streptomycin (sm) and were most likely the result of a common source exposure to one or possibly two highly infectious persons. five cases without multiple drug resistant organisms occurred in persons with previous positive tuberculin tests who had not received adequate therapy for prophylaxis of infection or treatment o ... | 1986 | 3094079 |
| analysis of a co-operative study in finding of mycobacteria. | comparative examinations in finding of mycobacteria carried out in two laboratories of different countries show a superiority of one lab only in one of two series of specimens. that indicates that the results are dependent not only on methods used but also on other factors as the nature of the specimens and the conditions of transport. a critical evaluation is necessary. | 1986 | 3094261 |
| field evaluation of enzyme-linked immunosorbent assay for the serodiagnosis of tuberculosis. | an enzyme-linked immunosorbent assay (elisa) was evaluated as a serodiagnostic test for active tuberculosis in la paz, bolivia. elisa was compared with sputum smear in 277 persons presenting to the instituto de torax and was used for screening in 1,458 military personnel. the test was performed under field conditions on 4-microliter samples of capillary blood obtained by finger prick. elisa was found to have a sensitivity of 69% and a specificity of 88%. sputum smear had a sensitivity of 79% and ... | 1986 | 3094416 |
| function and antigen recognition pattern of l3t4+ t-cell clones from mycobacterium tuberculosis-immune mice. | t-cell clones were established from mycobacterium tuberculosis-immunized mice. these clones had the phenotype thy-1+ l3t4+ lyt-2- and were restricted by the h-2i-a locus. after antigen stimulation, the t-cell clones secreted interleukin-2 and gamma interferon. factors produced by these t-cell clones activated normal bone marrow macrophages for antimycobacterial activity in vitro. furthermore, the t-cell clones could adoptively confer delayed-type hypersensitivity on normal recipient mice. these ... | 1986 | 3095237 |
| laboratory diagnosis of mycobacterial infections in patients with acquired immunodeficiency syndrome. | disseminated mycobacterial infections are commonly seen in acquired immunodeficiency syndrome (aids) patients, and laboratory culture is the best method for diagnosing these infections. in addition to conventional agar media, we used bactec 12a (johnston laboratories, inc., towson, md.) broth medium for culture. more isolates of mycobacterium avium complex and mycobacterium tuberculosis were recovered from 12a broth than from lowenstein-jensen or middlebrook 7h11 agar. also, the average detectio ... | 1986 | 3095369 |
| heating cells in acid methanol for 30 min without freeze-drying provides adequate yields of fatty acids and alcohols for gas chromatographic characterization of mycobacteria. | we studied the release of mycobacterial fatty acids (as methyl esters) and secondary alcohols after heating both wet and freeze-dried cells in methanolic hydrogen chloride for different time periods. a 30-min heating of the mycobacteria without prior freeze-drying was found adequate in a routine gas chromatographic procedure for strain and species characterization. | 1986 | 3095371 |
| serodiagnosis of intestinal tuberculosis by the soluble antigen fluorescent antibody test (safa test). | the diagnosis of intestinal tuberculosis can only be established by the tissue obtained during surgery or endoscopy. we investigated the role of the soluble antigen fluorescent antibody (safa) test with the possibility that it may prove to be a valuable technique for the serodiagnosis of intestinal tuberculosis. the sera of 38 patients and 60 control subjects were studied. mycobacterial saline extract was used as an antigen in the test. thirty-two (84%) of 38 patients with intestinal tuberculosi ... | 1986 | 3095560 |
| [clinico-anatomical and microbiological research on the residual changes following spontaneously cured tuberculosis]. | | 1986 | 3095824 |
| [growth of mycobacterium tuberculosis l forms on semipermeable cellophane membranes]. | | 1986 | 3095825 |
| drug-resistant tuberculosis in sierra leone. | culture and sensitivity tests were performed on tubercle bacilli from patients with tuberculosis attending a provincial general hospital in sierra leone, who appeared clinically to have drug-resistant infections. amongst the general intake of patients from 1978 to 1984 there was a 10.5% incidence of isoniazid resistance, with 7.7% of patients having strains resistant to both streptomycin and isoniazid, 1.3% resistant to rifampicin, and 0.8% resistant to ethambutol. multiple drug resistance was m ... | 1986 | 3095965 |
| the birmingham tuberculosis drug resistance register, 1956-1983. | the findings of the birmingham drug resistance register are recorded for the years 1956-83. in native born patients initial drug resistance was common up to 1969, but few new cases were discovered after 1970. in the immigrant population a peak of male discoveries was noted in 1968 and a peak of female discoveries in 1979, probably due to immigration patterns. in the native born, single drug resistance was the more common pattern; no initial isoniazid resistance has been detected in this group si ... | 1986 | 3095966 |
| enzyme linked protein-a: an elisa for detection of igg antibodies against mycobacterium tuberculosis in intestinal tuberculosis. | enzyme linked protein-a has been used to develop an enzyme-linked immunosorbent assay (elisa) to detect circulating igg antibodies to mycobacterium tuberculosis. the specific binding of protein-a to igg fractions through fc receptors, makes the test more specific for detection of total igg antibodies. the elisa system has been used for detection of circulating antibodies to m. tuberculosis h37ra in 22 patients with histologically proven intestinal tuberculosis and 88 healthy controls, in additio ... | 1986 | 3095967 |
| [studies of pyrazine derivatives. xvii. synthesis and the tuberculostatic activity of pyrazinyl-1,3,4-oxadiazole derivatives]. | | 1986 | 3096080 |
| demonstration of intrapleural immunoglobulin synthesis by agarose gel isoelectric focusing. a new specific method for the diagnosis of pleural effusions of inflammatory origin? | in order to demonstrate an intrapleural immunoglobulin (ig) synthesis, pleural effusions and serum from 14 patients with pleural effusions of various causes (inflammatory condition, malignancies, primary lung cancers, pleural metastasis, and congestive heart failure) were investigated by agarose gel isoelectric focusing (aief), antiserum immunofixation with monospecific antiserum against igg and iga, and quantitative estimation of igg and iga. intrapleural immunoglobulin synthesis was assumed to ... | 1986 | 3096176 |
| syntheses and biological activities of 2-(adamantylmethyl)benzimidazoles and -imidazolines. | | 1986 | 3096260 |
| local hepatic tuberculosis, the cause of a painful hepatic mass: case report and review of the literature. | local hepatic tuberculosis is an unusual form of extrapulmonary tuberculosis. the authors describe the case of a 39-year-old woman with this disease who posed diagnostic difficulties. she presented with abdominal pain, minimal constitutional symptoms, hepatomegaly and radiologic findings of a focal hepatic lesion. laparotomy was required for diagnosis. a literature review revealed that most individuals with local hepatic tuberculosis have fever, night sweats and weight loss. hepatomegaly is ofte ... | 1986 | 3096551 |
| community-acquired pneumonia caused by mixed aerobic bacteria. | mixed bacterial pneumonia caused by organisms other than anaerobes has been infrequently reported. we describe six cases and review the literature. two patients had co-infection with s pneumoniae and l pneumophila. two were infected with s pneumoniae and k pneumoniae and the others simultaneously harbored m tuberculosis and n asteroides. the first two sets of patients had bacteria isolated from usually sterile sites (blood and lung), while the latter harbored repeatedly isolated organisms not us ... | 1986 | 3096644 |
| bactericidal activity of alkaline glutaraldehyde solution against a number of atypical mycobacterial species. | the mycobactericidal activity of 2% alkaline glutaraldehyde solution was determined using standardized suspensions of 10 species of atypical mycobacteria and compared with that for virulent mycobacterium tuberculosis. suspensions of m. avium, m. intracellulare and m. gordonae were more resistant to disinfection by the glutaraldehyde than were virulent tubercle bacilli while m. kansasii, m. scrofulaceum and m. szulgae were somewhat more susceptible. mycobacterium marinum, m. smegmatis and m. fort ... | 1986 | 3096931 |
| diglycosyl diacylglycerol of mycobacterium tuberculosis. | a diglycosyl diacylglycerol was isolated from mycobacterium tuberculosis, and its structure was established by a combination of methylation analysis, 1h nuclear magnetic resonance, and fast atom bombardment-mass spectrometry. it is a 1,2-diacyl-[beta-d-glucopyranosyl(1"----6')-beta-d-glucopyranosyl(1'---- 3)]- sn-glycerol and exists in at least five molecular species differing in fatty acyl substituents. the major constituent fatty acids were identified as iso- and anteisopentadecanoate, iso- an ... | 1986 | 3096963 |
| susceptibility testing of slowly growing mycobacteria by a microdilution mic method with 7h9 broth. | based on previous success with rapidly growing mycobacteria, a microdilution mic system was devised for slowly growing mycobacterial species using 7h9 broth. test drugs included isoniazid, rifampin, ethambutol, streptomycin, clofazamine, and sulfamethoxazole. sixty isolates of four mycobacterial species, including mycobacterium tuberculosis, from patients who had never received drug therapy were evaluated in the system, as well as 25 drug-resistant isolates and 11 control strains. mics were read ... | 1986 | 3097069 |
| the kinetics of emergence and loss of mediator t lymphocytes acquired in response to infection with mycobacterium tuberculosis. | mice infected i.v. with the virulent erdman strain of mycobacterium tuberculosis exhibited three distinct phases of infection within the spleen. these consisted of a primary phase, characterized by the progressive growth of the organism; a secondary phase, in which the viable organism was progressively eliminated; and a tertiary phase, characterized by a chronic or slowly recrudescing disease state. passive transfer experiments, in which t cell-enriched spleen cells from immune donors were infus ... | 1987 | 3097148 |
| [urogenital tuberculosis--incidence and clinical laboratory characteristics]. | | 1986 | 3097381 |
| exogenous reinfection with tuberculosis in a shelter for the homeless. | we investigated an outbreak of tuberculosis in a large shelter for the homeless to assess the role of exogenous reinfection as opposed to reactivation of endogenous infection as the cause of secondary tuberculosis in this population. exogenous reinfection is considered relatively unimportant in the united states and other developed countries. of 49 shelter-related cases, 22 had cultures resistant to both isoniazid and streptomycin and of the same phage type, indicating recent transmission origin ... | 1986 | 3097543 |
| [clinical aspects of a single established isolation of mycobacteria]. | | 1986 | 3097629 |
| [clinical significance of finding mycobacterial l forms in patients with destructive pulmonary tuberculosis]. | | 1986 | 3097630 |
| [diagnostic significance of isolating mycobacterium tuberculosis l forms in patients at the sanatorium stage of treatment]. | | 1986 | 3097631 |
| [effect of rifampicin on the l transformation of a mycobacterial population in patients with destructive pulmonary tuberculosis]. | | 1986 | 3097632 |
| [cultivation of mycobacterium tuberculosis and opportunistic mycobacteria on a medium with n-alkanes]. | | 1986 | 3097633 |
| [changes in the biological properties of mycobacterium tuberculosis as affected by x-ray radiation]. | | 1986 | 3097634 |
| [epidemiologic and diagnostic significance of isolating bacteria from persons at risk for tuberculosis]. | | 1986 | 3097635 |
| [current concepts of the ultrastructure and function of the cell wall in mycobacterium tuberculosis]. | | 1986 | 3097636 |
| [critical thoughts on the terms "mycobacterium tuberculosis", "mycobacterium bovis" and "mycobacterium avium" in bergey's manual of determinative bacteriology, 8th edition, 1975, williams-wilkins company, baltimore]. | | 1986 | 3097688 |
| [primary resistance in the area of the district of split]. | | 1986 | 3097689 |
| rapid diagnosis of sputum negative miliary tuberculosis using the flexible fibreoptic bronchoscope. | acid fast bacilli are seldom identified by direct staining of sputum smears in patients with miliary tuberculosis, so that delays in diagnosis are common. we report 41 patients with miliary tuberculosis who had negative sputum smears and who underwent bronchoscopy, bronchial brushing, and transbronchial biopsy. in two patients the procedure was repeated. a definitive diagnosis was obtained from bronchoscopy in 34 patients (83%). bronchial brushings yielded mycobacterium tuberculosis in 24 of 42 ... | 1986 | 3097866 |
| [the medullary compression syndrome caused by bacterial spondylitis]. | | 1986 | 3097899 |
| [bacteriological diagnosis within the scope of tuberculosis control]. | | 1986 | 3097969 |
| metal analogues of mycobactin and exochelin fail to act as effective antimycobacterial agents. | mycobactins and exochelins from mycobacteria formed complexes with many heavy metals in the absence of iron. although many of these complexes affected the growth of m. tuberculosis and m. avium in laboratory culture medium and in serum the complexes were not stable enough in the presence of iron, which displaced the metal ion, to be of value as specific antimycobacterial agents. | 1986 | 3097987 |
| action of colistin (polymyxin e) on the lytic cycle of the mycobacteriophage d29 in mycobacterium tuberculosis. | the antibiotic colistin (polymyxin e) inhibited the lytic cycle of the mycobacteriophage d29 in the tubercle bacilli, but not the d29 adsorption. the protein and nucleic acid synthesis in d29-infected bacteria were not affected significantly. the inhibitory activity was reversed by washing off the antibiotic, and by addition of ca++, but not in media made iso-osmotic by addition of nacl or sucrose. transmission electron microscopy revealed an asymmetric to symmetric transition in the staining pr ... | 1986 | 3097989 |
| [studies of pyrazine derivatives. xx. synthesis and tuberculostatic activity of 3-pyrazinol-1,2,4-oxadiazole derivatives]. | | 1986 | 3098054 |
| enzyme-linked immunosorbent assay using mycobacterium tuberculosis antigen 5 for the diagnosis of pulmonary tuberculosis in china. | measurement of serum igg antibody to mycobacterium tuberculosis antigen 5 by enzyme-linked immunosorbent assay was evaluated as a serodiagnostic test for pulmonary tuberculosis in china. the test was 89% sensitive and 94 to 100% specific with high accuracies of prediction. among 82 tuberculous patients, antibody titer was related to the extent of pulmonary disease. among control subjects, false positive tests were encountered among 5 of 52 persons with other pulmonary disease and not among 30 he ... | 1986 | 3098148 |
| preliminary studies on bacteriophage typing of mycobacterium tuberculosis strains isolated in salamanca (spain). | a phage typing of 202 strains of mycobacterium tuberculosis isolated in central and northwest spain was carried out. the commonest phage type was a (64%) and within this type a (45%). this was followed in frequency by phage type b (26%) and in last place type i (10%). no relationship was observed between the phage type and the geographical or anatomical origin of the strains. | 1986 | 3098576 |
| activation of macrophages to inhibit proliferation of mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages. | when cultured in 20% heat-inactivated human serum, human monocytes from seven donors were not on average significantly different from non-activated murine peritoneal cells (cultured simultaneously and in an identical manner) in their ability to inhibit bcg and, when calculated relative to growth of bacilli in the same medium without macrophages, to enhance the growth of mycobacterium tuberculosis. recombinant gamma-interferon caused marked inhibition of virulent m. tuberculosis by murine (balb/c ... | 1986 | 3098676 |
| production, characterization, and species specificity of five monoclonal antibodies to mycobacterium tuberculosis. | the production and characterization of five monoclonal antibodies to mycobacterium tuberculosis are described. specificity of the monoclonal antibodies was tested against other mycobacterial species by an enzyme-linked immunosorbent assay and immunoblots. hgt 3a, an immunoglobulin m (igm) antibody, recognizes a molecule of 38,000 molecular weight present only in the tuberculosis complex of m. tuberculosis and mycobacterium bovis bcg. hgt 6, an igg1 antibody, recognized two molecules with molecul ... | 1987 | 3098780 |
| enzyme immunoassay using bcg in serodiagnosis of pulmonary tuberculosis. | amounts of mycobacterium tuberculosis antibodies were determined in sera from patients with either active or inactive tuberculosis and in healthy subjects by an immunoenzymatic assay in which whole bcg cells attached covalently to polystyrene disks were used as antigen. statistically significant differences (p less than 0.005) were found both between the active and inactive tuberculosis groups and between the active group and healthy controls. no significant differences were found between the in ... | 1986 | 3098836 |
| effect of cyclopiazonic acid on delayed hypersensitivity to mycobacterium tuberculosis, complement activity, serum enzymes, and bilirubin in guinea pigs. | cyclopiazonic acid (cpa) was given daily to groups of guinea pigs at doses of 0.00625, 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4, 0.8, 1.6, and 1.95 mg/day for 30 days. all guinea pigs were sensitized and survivors were skin tested twenty-five days later with mycobacterium tuberculosis. mortalities occurred only in the two greatest dose groups. signs of disease included anorexia, roughened hair coat, diarrhea and incoordination. the major histopathologic changes occurring in these two groups included h ... | 1986 | 3099199 |
| [further study on the decontaminated pretreatment of mycobacterium tuberculosis cultures]. | | 1986 | 3100256 |
| [in vitro activity of ciprofloxacin and ofloxacin against mycobacterium tuberculosis, m. avium, m. africanum, m. kansasii and bcg strains]. | the in vitro activity of ciprofloxacin and ofloxacin against 33 strains of mycobacteria was investigated in a comparative study. the resulting mic values were compared with serum levels, measured in a cross-over study. possible therapeutic application of these substances in mycobacterial infections are being discussed. we found the antimycobacterial activity of ciprofloxacin to be insufficient for its clinical application, whereas the corresponding mic values for ofloxacin could be achieved in v ... | 1986 | 3100424 |
| [comparison of in vitro antimycobacterial activities of ansamycin and rifampicin]. | | 1986 | 3100853 |
| [new active drugs against the tuberculosis bacillus and other mycobacteria]. | | 1986 | 3100907 |
| [characteristics of patients--chronic carriers of mycobacterium tuberculosis in poland 1984]. | | 1986 | 3101043 |
| [effect of thermal treatment on the structure and biological properties of tuberculin]. | the effect of heat treatment used in the course of tuberculin production by mycobacteria tuberculosis cells on the structure and biological activity of tuberculin was studied. methods of preparative and analytical gel-filtration were used. the largest quantity of the biologically active component was obtained after 2-hour heat treatment of the mycobacteria culture. | 1986 | 3101059 |
| [effect of the combined action of laser irradiation and an alternating magnetic field on the multiplication of mycobacterium tuberculosis]. | | 1986 | 3101060 |
| an enzyme-linked immunosorbent assay using adsorbed mycobacterial sonicates for the serodiagnosis of tuberculosis. | sera from 123 patients with confirmed tuberculosis and 576 patients with other non-mycobacterial diseases were tested for antibodies to an adsorbed mycobacterial sonicate antigen employing an enzyme-linked immunosorbent assay. the results show significant differences in igg levels between sera from tuberculosis patients and controls. the results of delayed hypersensitivity skin-test reactions to purified protein derivative in both the patient and control groups were unrelated to antibody levels. ... | 1987 | 3101208 |
| evaluation of a radiometric method for pyrazinamide susceptibility testing of mycobacterium tuberculosis. | pyrazinamide susceptibility testing of mycobacterium tuberculosis requires an acid environment. by controlling the method of acidification and the quality and quantity of the inoculum, the test can be performed with the bactec radiometric system (johnston laboratories, towson, md.). we acidified bactec 7h12 medium with buffered phosphoric acid and adjusted the test inoculum to 1/10 of that usually employed in bactec protocols; after 5 days of growth we correctly identified 36 of 36 strains susce ... | 1986 | 3101586 |
| ethambutol mics and mbcs for mycobacterium avium complex and mycobacterium tuberculosis. | we determined the mics of ethambutol for both mycobacterium avium and mycobacterium tuberculosis strains by using broth dilution (7h12 broth, radiometric method) and agar dilution (7h11 agar) methods. we found the mics to be much lower in liquid than in solid medium. the broth-determined mics for susceptible m. tuberculosis and most of the m. avium strains were comparable to the levels in blood of patients, being lower than the peak levels. we propose that the mics, determined radiometrically in ... | 1986 | 3101588 |
| implications of emerging isoniazid resistance in mycobacterium tuberculosis in korea. | in 1981, the korean national institute of health (knih) reported that 17% of all tuberculosis patients had primary resistance to isoniazid while an additional 17% acquired isoniazid resistance during chemotherapy. this 34% isoniazid resistance rate in the republic of korea, where an estimated 6-8% of the total population have active tuberculosis, poses significant concerns regarding management of u.s. military health care beneficiaries who develop tuberculosis or have tuberculosis skin test conv ... | 1987 | 3101660 |
| mycobacteria and cryptococci cultured from the buffy coat of aids patients prior to symptomatology: a rationale for early therapy. | culture of the buffy coat layer of the peripheral blood of 14 aids patients demonstrated sustained mycobacteremia or fungemia: 11 with mycobacterium avium-intracellulare, 2 with cryptococcus neoformans, and one with mycobacterium tuberculosis. the early detection of these agents prior to the onset of overt symptomatology of disseminated infection due to these microorganisms allowed speculations on an early phase bacteremia and the proposal of prompt inception of antimicrobial therapy while the m ... | 1986 | 3101713 |
| monoclonal anti-tuberculosis antibodies react with dna, and monoclonal anti-dna autoantibodies react with mycobacterium tuberculosis. | classical models of experimental autoimmune diseases, such as adjuvant arthritis entail the use of mycobacteria. furthermore, bcg immunotherapy may be followed by arthritic symptoms. to test the infection-autoimmunity relationship of mycobacteria, we used monoclonal antibodies raised against m. tuberculosis and against dna. murine monoclonal anti-tb antibodies were found to react with ssdna, dsdna and other polynucleotides. monoclonal anti-dna autoantibodies derived from patients and mice with s ... | 1986 | 3102132 |
| comparison of antigens and antisera in crossed immunoelectrophoresis by dual dilution. | the localization of individual precipitates in the crossed immunoelectrophoresis (cie) pattern is an important feature for their identification, but in a given system this pattern may vary markedly when different antigen preparations or antisera are used. two different antigen preparations or antisera may be compared by mixing them in various proportions in a set of four cie plates. the amounts of the preparations to be compared are selected to obtain a gradual change in position of individual p ... | 1987 | 3102615 |
| new approaches to the rapid diagnosis of tuberculous meningitis. | | 1987 | 3102626 |
| activity of adenosine deaminase in cerebrospinal fluid for the diagnosis and follow-up of tuberculous meningitis in adults. | we studied the activity of adenosine deaminase in the cerebrospinal fluid of 40 normal controls and 205 patients who were grouped according to disease (tuberculous, viral, and purulent meningitis; neoplasms; stroke; and miscellaneous). the mean enzyme value was clearly higher for the patients with tuberculous meningitis (15.7 +/- 4.3 u/liter) than for the other patients (1.4 +/- 1.5 u/liter). the sensitivity of the test for diagnosing tuberculous meningitis was 1 and specificity, 0.99. the enzym ... | 1987 | 3102627 |
| radioimmunoassay for detecting mycobacterium tuberculosis antigen in cerebrospinal fluids of patients with tuberculous meningitis. | a biotin-avidin radioimmunoassay for detecting mycobacterium tuberculosis antigen has been developed. the assay involves sandwiching mycobacterial antigens from sonicate preparations and cerebrospinal fluids between two antibodies produced in burros and rabbits. the reaction is amplified by using biotinylated antibody to rabbit igg and 125i-labeled avidin. the assay has a sensitivity of 20 ng/ml and shows less than 5% cross-reactivity with six other mycobacteria. we studied patients with untreat ... | 1987 | 3102628 |
| [current status of urogenital tuberculosis]. | | 1986 | 3102829 |
| isolation and characterization of new glycolipids from mycobacterium tuberculosis h37rv. | | 1986 | 3103042 |
| [tuberculostatic action of piperidinoethyl esters of alkoxyphenylcarbamide acid in vitro]. | | 1986 | 3103140 |
| [the principal antitubercular agents]. | | 1986 | 3103194 |
| pulmonary tuberculosis in elderly men. | the clinical manifestations, predisposing factors, and diagnostic approach to 29 young men and 35 elderly men with pulmonary tuberculosis admitted to a veterans administration hospital were compared. elderly men had a higher number of underlying conditions such as atherosclerosis, previous gastrectomy, and malignancy, whereas alcoholism was more prevalent in the younger group. the classic symptoms and signs of tuberculosis were noted in a significantly higher proportion of the younger group: fev ... | 1987 | 3103441 |
| a rapid method for the evaluation of new antituberculous agents. | fifty-one new synthetic compounds belonging to four different series, namely (1a) substituted aryl-4-(substituted phenyl) succinimide; (1b) n-(substituted methyl)-4-(heterocyclic) succinimide; (2) heterocyclic 4-(5'-nitro-2-furyl) thiazoles; (3) substituted aryl-4-(3', 4'-dihydroxy phenyl) thiazoles, and (4) phenyl-n,n-1,2,3-bis-methoxy carbonyl guanidines were screened for antituberculous activity using a conventional broth dilution test (bdt) and a liquid scintillation radiometric method (lsrm ... | 1987 | 3103991 |
| diagnosis of intrathoracic tuberculosis by detection of tubercle and/or tubercular antigen (tb ag) in bronchial aspirate. | | 1987 | 3104205 |
| a simple new method for using antigens separated by polyacrylamide gel electrophoresis to stimulate lymphocytes in vitro after converting bands cut from western blots into antigen-bearing particles. | the individual antigenic components present in microgram quantities of complex mixtures can be separated reproducibly by polyacrylamide gel electrophoresis and transferred onto nitrocellulose blots. we report that the ng quantities of antigen present in single lines cut from such western blots can be used to induce maximal lymphoproliferative responses in 30-60 microtitre wells. in order to achieve this the excised lines of antigen-bearing nitrocellulose sheet must be converted into antigen-bear ... | 1987 | 3104476 |
| the relation between allergy and immunity in leprosy. | | 1987 | 3104515 |
| [the effect of catalase added to löwenstein-jensen medium on the rate of growth of m. tuberculosis]. | in this study, the effect of catalase on the rate of growth mycobacterium tuberculosis has been investigated. thirty-five sputa were inoculated on the löwenstein-jensen medium and löwenstein-jensen medium modified by the addition of catalase 4 mcg/ml. only four sputa were observed to have an early growth on the löwenstein-jensen medium with catalase five days than löwenstein-jensen medium. of the 55 strains grown in the löwenstein-jensen medium the following results were obtained from the inocul ... | 1986 | 3104733 |
| [treatment of pulmonary tuberculosis patients with primary drug resistant mycobacterium tuberculosis]. | | 1987 | 3104897 |
| [differentiation of m. tuberculosis and m. bovis using the salicylate test and nitrate reduction]. | | 1987 | 3104898 |