| propylthiouracil-induced interstitial pneumonia in a caucasian women with amiodarone induced thyrotoxicosis. | background. propylthiouracil (ptu) therapy is associated with a variety of adverse reactions, among the most rare being interstitial pneumonia. to date, this has been reported in four asian patients with autoimmune hyperthyroidism. here we describe a caucasian woman who developed a bronchiolitis obliterans organizing pneumonia (boop)-like interstitial pneumonia after ptu administration for amiodarone-induced thyrotoxicosis. patient findings. the patient was a 68 year old women who had been tre ... | 2011 | 22150593 |
| in vitro and in vivo antiparasitic activity of azadirachtin against argulus spp. in carassius auratus (linn. 1758). | argulus is one of the most common and predominant ectoparasites which cause serious parasitic disease and is a potent carrier of viruses and bacteria in the ornamental fish industry. in recent years, organic (herbs)-based medicines are widely used to cure the disease, and neem (sarbaroganibarini) medicine is very popular and effective throughout the world. the present study was conducted to find the effects of azadirachtin against argulus spp. on carassius auratus under in vitro and in vivo cond ... | 2011 | 22042504 |
| laparoscopic radical prostatectomy: oncological and functional outcomes of 559 cases in siriraj hospital, thailand. | to evaluate the results of oncological and functional outcomes of laparoscopic radical prostatectomy (lrp) during the first five years experience in siriraj hospital. | 2011 | 21863675 |
| free thyroxine, free triiodothyronine and thyroid-stimulating hormone before and after hemodialysis in saudi patients with end-stage renal disease: is there any difference? | patients on regular hemodialysis (hd) suffer from a chronic illness that is believed not to involve the thyroid gland. however, they may have low levels of serum thyroxine (t4) and tri-iodothyronine (t3). it was found earlier that serum total t3 and free t4 concentrations were significantly higher immediately after a hd session than before. in this single-center prospective study, we evaluated the difference between free t3 (ft3), free t4 (ft4) and thyroid-stimulating hormone (tsh) levels before ... | 2011 | 21912019 |
| locally advanced prostate cancer: a population-based study of treatment patterns. | study type - therapy (practice patterns) level of evidence 2b what's known on the subject? and what does the study add? the treatment of locally advanced prostate cancer varies widely even though there is level one evidence supporting the use of multimodality therapy as compared with monotherapy. this study defines treatment patterns of locally advanced prostate cancer within the united states and identifies predicators of who receives multimodality therapy rather than monotherapy. objective: • ... | 2011 | 22085255 |
| acanthamoeba belonging to t3, t4, and t11: genotypes isolated from air-conditioning units in santiago, chile. | free-living amoebae (fla) of the genus acanthamoeba are widely distributed in the environment, in the air, soil, and water, and have also been isolated from air-conditioning units. the objective of this work was to investigate the presence of this genus of fla in the air-conditioning equipment at the institute of public health of chile in santiago, chile. water and air samples were collected from air-conditioning systems and were checked for the presence of acanthamoeba spp. positive samples wer ... | 2011 | 22092528 |
| [treatment strategy for stage ii/iii( non-t4)advanced esophageal cancer in high-risk patients]. | we evaluated treatment strategies for stage ii/iii( non-t4) advanced esophageal cancer in high-risk( hr) patients and analyzed the relationship between e-pass scoring system( e-pass) and hr patients retrospectively. the subjects were 85 patients who received the treatment for stage ii/iii( non-t4) advanced esophageal cancer between 2006 and 2010 in our institute. the patients were divided into the hr and non high-risk( nhr) group. in this study, hr patients were defined as satisfying at least on ... | 2011 | 22202389 |
| a single-step competitive binding assay for mapping of single dna molecules. | optical mapping of genomic dna is of relevance for a plethora of applications such as scaffolding for sequencing and detection of structural variations as well as identification of pathogens like bacteria and viruses. for future clinical applications it is desirable to have a fast and robust mapping method based on as few steps as possible. we here demonstrate a single-step method to obtain a dna barcode that is directly visualized using nanofluidic devices and fluorescence microscopy. using a m ... | 2011 | 22166208 |
| total laryngectomy for laryngeal cancer in a nigerian tertiary health center: prognosis and outcome. | advanced laryngeal cancers presenting with upper airway obstruction are a common scenario in sub-saharan africa, requiring operative intervention as a priority. | 2011 | 22022650 |
| age, place of living and education influences the pregnancy universal thyroid function screening program attendance - questionnaire study. | the aim of this study was to assess attendance at the universal screening programme for thyroid function in pregnancy and attempt to evaluate the influence of age, number of past pregnancies, level of education, and place of residence on the attendance. the study was performed by means of a questionnaire. | 2011 | 22069102 |
| snd2, a nac transcription factor gene, regulates genes involved in secondary cell wall development in arabidopsis fibres and increases fibre cell area in eucalyptus. | abstract: background: nac domain transcription factors initiate secondary cell wall biosynthesis in arabidopsis fibres and vessels by activating numerous transcriptional regulators and biosynthetic genes. nac family member snd2 is an indirect target of a principal regulator of fibre secondary cell wall formation, snd1. a previous study showed that overexpression of snd2 produced a fibre cell-specific increase in secondary cell wall thickness in arabidopsis stems, and that the protein was able t ... | 2011 | 22133261 |
| spinal pilocytic astrocytoma in an elderly patient. | objective: astrocytomas are the most common intramedullary spinal cord tumor (imsct) in pediatric and adolescent patients and the incidence decreases with age. there are very few cases of spinal pilocytic astrocytomas (who grade 1) reported after the fourth decade. we report the oldest known case of a pathologically confirmed spinal pilocytic astrocytoma. methods: a 78-year-old female presented with 12 months of bilateral lower extremity numbness. magnetic resonance imaging (mri) revealed cord e ... | 2011 | 22120566 |
| genotyping of acanthamoeba isolated from water in recreational areas of tehran, iran. | a comprehensive survey assessing the presence of acanthamoeba was conducted on 50 samples from water sources in parks and public squares from 22 municipal districts of tehran, iran. the prevalence and genotypes of acanthamoeba were determined by pcr and the pcr fragments of ribosomal rna genes sequenced. sixteen (32%) samples were positive for acanthamoeba spp. sequence analysis revealed that the positive isolates belonged to the t4 and t5 genotypes. fourteen isolates (87.5%) were t4, and two (1 ... | 2011 | 21976207 |
| anthrax vaccine antigen-adjuvant formulations completely protect new zealand white rabbits against challenge with bacillus anthracis ames strain spores. | in an effort to develop an improved anthrax vaccine that shows high potency, five different anthrax protective antigen (pa)-adjuvant vaccine formulations that were previously found to be efficacious in a nonhuman primate model were evaluated for their efficacy in a rabbit pulmonary challenge model using bacillus anthracis ames strain spores. the vaccine formulations include pa adsorbed to alhydrogel, pa encapsulated in liposomes containing monophosphoryl lipid a, stable liposomal pa oil-in-water ... | 2012 | 22089245 |
| simulation of post-thyroidectomy treatment alternatives for t3 or t4 replacement in pediatric thyroid cancer patients. | background: as with adults, thyroidectomy of pediatric patients with differentiated thyroid cancer is often followed by 131i remnant ablation. a standard protocol is to give normalizing oral t4 or t3 after surgery and then withdraw it for 2 to 6 weeks. thyroid remnants or metastases are treated most effectively when serum tsh is high, but prolonged withdrawals should be avoided to minimize hypothyroid morbidity. methods: a published feedback control system model of adult human thyroid hormon ... | 2011 | 22191403 |
| measurements of canine aqueous humor inflammatory mediators and the effect of carprofen following anterior chamber paracentesis. | phase i: to evaluate levels of prostaglandin e(2) (pge(2) ), nitrites and nitrates (no(x) ), tumor necrosis factor-alpha (tnf-α) and expression of inducible cyclo-oxygenase (cox-2), nitric oxide synthase (nos-2), and matrix metalloproteinases (mmp-3 and -9) in canine aqueous humor following repeated anterior chamber paracenteses (acp). phase ii: to evaluate the effect of carprofen on pge(2) , no(x) , and tnf-α in canine aqueous humor following acp. | 2011 | 21929606 |
| oxidative stress parameters in women with breast cancer undergoing neoadjuvant chemotherapy and treated with nutraceutical doses of oral glutamine. | to evaluate the effects of oral administration of gln on the oxidative stress in women with breast cancer undergoing neoadjuvant fac chemotherapy (5 fluouracil 500 mg/m²+doxorubicin 50 mg/m²+cyclophosphamide 500 mg/m² body surface area). | 2011 | 21971664 |
| effect of ageing and pulmonary inflammation on the incidence and number of cross-bridging structures in pneumothorax patients. | there is an improved prognosis for t4 non-small-cell lung cancer in patients who show particular patterns of direct mediastinal invasion. the particular patterns suggest the presence of direct pathways other than the pulmonary hilum between each of the lungs and the mediastinum/chest wall. | 2011 | 22042982 |
| investigation of bacteriophage t4 by atomic force microscopy. | bacteriophage t4 was visualized using atomic force microscopy (afm). the images were consistent with, and complementary to electron microscopy images. head heights of dried particles containing dna were about 75 nm in length and 60 nm in width, or about 100 nm and 85 nm respectively when scanned in fluid. the diameter of hydrated tail assemblies was 28 nm and their lengths about 130 nm. seven to eight pronounced, right-handed helical turns with a pitch of 15 nm were evident on the tail assemblie ... | 2011 | 22164350 |
| aerobic capacity with hybrid fes rowing in spinal cord injury: comparison with arms-only exercise and preliminary findings with regular training. | to determine the magnitude and range of increases in peak aerobic capacity with hybrid-functional electrical stimulation (fes) rowing versus arms-only rowing in persons with spinal cord injury. | 2011 | 21944299 |
| [treatment of lateral node metastasis from lower rectal cancer]. | lateral lymphatics of the rectum originate in the area where branches of the inferior hypogastric plexus and the middle rectal vessels from the internal iliac vessels enter the mesorectum below the level of the peritoneal reflection in the pelvis, then reach the bifurcation of iliac vessels along the internal iliac vessels. among lateral lymph nodes, the middle rectal, obturator, and internal iliac lymph nodes are important from the viewpoint of both the incidence of metastais and treatment effe ... | 2011 | 21941823 |
| the effect of patient-controlled intravenous analgesia on postoperative hypokalemia in patients undergoing laparoscopic cholecystectomy. | we investigated whether hypokalemia developed during the postoperative period and whether the use of intravenous patient-controlled analgesia (iv-pca) could decrease the incidence of postoperative hypokalemia in patients who underwent laparoscopic cholecystectomy. | 2011 | 21863389 |
| optimizing the management of cutaneous melanoma in the elderly. | the incidence of melanoma in patients aged ≥ 65 years is increasing. melanoma characteristics appear to be different in the elderly, and outcomes worse. we undertook this study to characterize our experience with melanoma in the elderly and identify factors associated with outcome. | 2011 | 22000197 |
| locally advanced nasopharyngeal carcinoma: current and emerging treatment strategies. | although nasopharyngeal carcinoma (npc) is a widespread malignant tumor, it is particularly frequent in southeast asia. although t1 tumors can be effectively controlled with exclusive radiotherapy, this treatment modality is insufficient for most npc patients, who present with locally advanced disease at diagnosis. in fact, for stages ranging from t2b n0 to t4 n3, definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam radiotherapy. t ... | 2011 | 22171280 |
| speed and efficiency in walking and wheeling with novel stimulation and bracing systems after spinal cord injury: a case study. | to compare various novel and conventional systems for locomotion, a 25-year-old man was studied with motor complete spinal cord injury at the t4/5 level. he used various devices in the community, and changes in speed, physiological cost index (pci), and oxygen consumption were measured periodically. speed was fastest with a conventional manual wheelchair (nearly 120 m/min in a 4-min test). speed was about 30% less, but the pci was lowest (highest efficiency) using functional electrical stimulati ... | 2005 | 22151555 |
| squamous carcinoma and dysplasia of the conjunctiva and cornea an analysis of 101 cases. | objective: to evaluate clinical and histopathologic factors of squamous conjunctival neoplasia associated with recurrence. design: retrospective, clinical case series. participants: one hundred one eyes of 99 patients with squamous conjunctival dysplasia, carcinoma in situ, or squamous cell carcinoma. methods: review of the medical records, pathology reports, and color photographs. main outcome measures: demographic information, laterality, tumor size, extension, pathologic diagnosis, seventh ed ... | 2011 | 22189448 |
| Social stress-induced hypothyroidism is attenuated by antidepressant treatment in rats. | Although serotonergic system has been classically implicated in mood modulation, there has been relatively little study on the relationship between this system and thyroid hormones (TH) economy in stress models. When TH are studied, the effects of stress on thyroid function seems to be complex and depend on the kind and time of stress which counts for the elusiveness of mechanisms underlying changes in TH economy. Herein, we hypothesized that serum TH are affected in a time-dependent fashion aft ... | 2012 | 21903114 |
| preliminary report--near total laryngectomy for scc larynx. | a retrospective analysis was performed on patients subjected to near-total laryngectomy at aga khan university hospital karachi from september 2006 and may 2010, to evaluate the functional outcome of near total laryngectomy and its effect on disease control. in all of these advanced stage laryngeal-hypopharyngeal squamous cancer patients, the disease was limited to one side of the larynx-hypopharynx. four patients were staged as t3 and rest were t4; near total laryngectomy was done in all 07 pat ... | 2011 | 22204224 |
| characterization of tchmgb, a high mobility group b family member protein from trypanosoma cruzi. | high mobility group b (hmgb) proteins are highly abundant non-histone chromatin proteins that play important roles in the execution and control of many nuclear functions. based on homology searches, we identified the coding sequence for the tchmgb protein, an hmgb family member from trypanosoma cruzi. tchmgb has two hmg box domains, similar to mammalian hmgbs, but lacks the typical c-terminal acidic tail. instead, it contains a 110 amino acid long n-terminal domain. the tchmgb n-terminal domain ... | 2011 | 21854779 |
| A randomized controlled study investigating static and dynamic balance in older adults after training with pilates. | Bird M-L, Hill KD, Fell JW. A randomized controlled study investigating static and dynamic balance in older adults after training with Pilates. | 2012 | 21975148 |
| adjuvant radiotherapy in the treatment of invasive intraductal papillary mucinous neoplasm of the pancreas: an analysis of the surveillance, epidemiology, and end results registry. | background: management and outcomes of patients with invasive intraductal papillary mucinous neoplasm (ipmn) of the pancreas are not well established. we investigated whether adjuvant radiotherapy (rt) improved cancer-specific survival (css) and overall survival (os) among patients undergoing surgical resection for invasive ipmn. methods: the surveillance, epidemiology, and end results (seer) registry was used in ... | 2011 | 22002799 |
| the effects of withholding feed and water on carcass shrinkage and meat quality in beef cattle. | eighty beef crossbred steers with an average weight of 493 kg (4·66 kg sd) were allocated at random to one of five treatments to assess the effects of withholding feed and water on carcass shrinkage and meat quality. the five treatments were: slaughter from the feedlot (t1); and 12, 24, 36 and 48 h periods without feed and water prior to slaughter (t2-5).weights were taken of the live animal and the carcass to monitor shrinkage along with relevant meat quality measurements. there were no treatme ... | 1990 | 22055514 |
| Is celiac axis resection justified for T4 pancreatic body cancer? | The clinical impact of the distal pancreatectomy with en-bloc celiac axis resection for locally advanced pancreatic body cancer remains unclear. | 2012 | 22088810 |
| minimally invasive lateral approach for symptomatic thoracic disc herniation: initial multicenter clinical experience. | object symptomatic herniated thoracic discs remain a surgical challenge and historically have been associated with significant complications. while neurological outcomes have improved with the abandonment of decompressive laminectomy, the attempt to minimize surgical complications and associated morbidities continues through less invasive approaches. many of these techniques, such as thoracoscopy, have not been widely adopted due to technical difficulties. the current study was performed to ex ... | 2011 | 22176427 |
| excess folate during adolescence suppresses thyroid function with permanent deficits in motivation and spatial memory. | cognitive and memory deficits can be caused or exacerbated by dietary folate deficiency, which has been combatted by the addition of folate to grains and dietary supplements. the recommended dose of the b9 vitamin folate is 400 µg/day for adolescents and non-pregnant adults, and consumption above the recommended daily allowance is not considered to be detrimental. however, the effects of excess folate have not been tested in adolescence when neuro and endocrine development suggest possible vulne ... | 2011 | 22050771 |
| clinicopathological features and prognostic factors of gastric cancer patients aged 40 years or younger. | background and objectives: gastric adenocarcinoma (gc) occurs frequently in the sixth decade of life and is uncommon in patients aged 40 years or younger. the aims of this study were to define the clinicopathological features and elucidate the prognostic factors of gc in the young. methods: between 1998 and 2006, 1,815 gc patients undergoing resection were enrolled in a prospective database. the findings for 115 (6.0%) patients aged 40 years or younger were compared with those of 1,009 patients ... | 2011 | 22116742 |
| thyroid axis function and dysfunction in critical illness. | acutely ill patients typically present with low circulating t3 and increased reverse t3. when illness is severe and prolonged, also pulsatile tsh secretion and circulating t4 levels are low. this constellation of changes within the thyroid axis is referred to as the low t3 syndrome or non-thyroidal illness syndrome (nti), and comprises both peripheral and central alterations in the thyroid axis. acute alterations are dominated by changes in thyroid hormone binding, in thyroid hormone uptake by t ... | 2011 | 21925075 |
| oxidative stress following administration of levothyroxine in subjects suffering from primary hypothyroidism. | oxidative stress (os) in subjects with primary hypothyroidism under therapy with l-t4 might be the cause of the side effects commonly found with this treatment. | 2011 | 22108484 |
| i-131 spect/ct elucidates cryptic findings on planar whole-body scans and can reduce needless therapy with i-131 in post-thyroidectomy thyroid cancer patients. | interpreting i-131 whole-body scans (wbss) after thyroidectomy for thyroid cancer is not simple. there are scans in which interpretation is speculative because of cryptic findings (cf). complexity is added in scans that are done a week after an ablative or therapeutic dose of i-131 because not only is i-131-labeled thyroxine (t4) distributed throughout the body, but inorganic i-131 that is derived from the de-iodination of t4 may be also detected. we present our observations regarding the analys ... | 2011 | 22007920 |
| [viral sorption on polyaniline, carbon nanotubes and their based nanocomposites]. | the paper gives data on the sorption of influenza virus pandemic strain a/iiv-moscow/01/2009 (h1n1)swl, avian influenza viruses with a/h5 and a/h7 hemagglutinin, poliomyelitis virus, and t4-d bacteriophage on polyaniline sorbents, carbon nanotubes, and their based nanocomposites. the sorption of viruses occurred in different solutions at 4-37 degrees c during 15 min or more. the rate of viral sorption depended on the structure of sorbents. | 2011 | 21899064 |
| [locally advanced rectal cancer managment: which role for the pathologist in 2011?]. | locally advanced rectal cancers mainly correspond to lieberkünhien adenocarcinomas and are defined by t3-t4 lesions with or without regional metastatic lymph nodes. such tumors benefit from neoadjuvant treatment combining chemotherapy and radiotherapy, followed by surgery with total mesorectum excision. such a strategy can decrease the rate of local relapse and lead to an easier complementary surgery. the pathologist plays an important role in the management of locally advanced rectal cancer. in ... | 2011 | 22172116 |
| new dual-energy x-ray absorptiometry equipment in the assessment of vertebral fractures: technical limits and software accuracy. | objective: the aim of this study was to investigate software accuracy and influence of body mass index on image quality of lunar idxa (lunar, madison, wi, usa; software encore 12.0) in vertebral fracture (vfs) assessment. materials and methods: we enrolled 65 normal or overweight patients (group 1) and 64 obese patients (group 2) with indication for morphometric evaluation of the spine. patients underwent idxa, w ... | 2011 | 22005799 |
| differentiated thyroid cancer in navarra (spain): historic cohort results (1987-2003). | introduction. navarra has the highest incidence of differentiated thyroid cancer in spain. the aim of this study was to review its management carried out by the navarra's multidisciplinary thyroid disease unit, from 1987 to 2003. material and methods. 325 patients were studied to find the incidence, prevalence, and prognostic factors. statistical analysis comprised univariate and multivariate cox proportional hazards regression models for survival and tumor recurrence. results. the average annua ... | 2011 | 22084734 |
| phase ii study of long-term androgen suppression with bevacizumab and intensity-modulated radiation therapy (imrt) in high-risk prostate cancer. | purpose: we report a phase ii trial assessing the acute and late toxicities of intensity-modulated radiation therapy (imrt), long-term androgen suppression (ltas), and bevacizumab in patients with high-risk localized prostate cancer. methods and materials: we treated 18 patients with ltas with bicalutamide and goserelin in combination with bevacizumab and imrt. bevacizumab (10 mg/kg every 2 weeks) was administered for the first 16 weeks, and 15 mg/kg was then given every 3 weeks for 12 additiona ... | 2011 | 22208976 |
| free energy perturbation hamiltonian replica-exchange molecular dynamics (fep/h-remd) for absolute ligand binding free energy calculations. | free energy perturbation with replica exchange molecular dynamics (fep/remd) offers a powerful strategy to improve the convergence of free energy computations. in particular, it has been shown previously that a fep/remd scheme allowing random moves within an extended replica ensemble of thermodynamic coupling parameters "lambda" can improve the statistical convergence in calculations of absolute binding free energy of ligands to proteins [j. chem. theory comput. 2009, 5, 2583]. in the present st ... | 2010 | 21857813 |
| kinetic characterization of single strand break ligation in duplex dna by t4 dna ligase. | t4 dna ligase catalyzes phosphodiester bond formation between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex dna in three steps: 1) enzyme-adenylylate formation by reaction with atp; 2) adenylyl transfer to a 5'-phosphorylated polynucleotide to generate adenylylated dna; and 3) phosphodiester bond formation with release of amp. this investigation used synthetic, nicked dna substrates possessing either a 5'-phosphate or a 5'-adenylyl phosphate. steady state experiments with a nicked su ... | 2011 | 22027837 |
| recommendations and expert opinion on the treatment of locally advanced rectal cancer in spain. | in spain 22,000 new cases of colorectal cancer are diagnosed each year, with 13,075 deaths resulting from this disease. around 70% of colorectal cancers are localised in the colon and 30% in the rectum. a group of spanish experts established recommendations on what would be the best strategy in the treatment of locally advanced rectal cancer (larc). adequate assessment of local tumour extension, including high-resolution magnetic resonance imaging and endorectal ultrasound, is essential for succ ... | 2011 | 22126729 |
| relationship of obesity, androgen receptor genotypes and biochemical failure after radical prostatectomy. | background: obesity and androgen metabolism have been implicated in the progression of prostate cancer. obesity has been associated with increased risk for advanced disease and biochemical failure after treatment. this association may be the result of changes in androgen metabolism that occur with obesity and are mediated by the androgen receptor (ar). methods: to evaluate the effects of obesity and ar polymorphisms on biochemical failure, we conducted a study of 536 caucasian prostate cancer ca ... | 2011 | 22025404 |
| improved binding free energy predictions from single-reference thermodynamic integration augmented with hamiltonian replica exchange. | reliable predictions of relative binding free energies are essential in drug discovery, where chemists modify promising compounds with the aim of increasing binding affinity. conventional thermodynamic integration (ti) approaches can estimate corresponding changes in binding free energies, but suffer from inadequate sampling due to ruggedness of the molecular energy surfaces. here, we present an improved ti strategy for computing relative binding free energies of congeneric ligands. this strateg ... | 2011 | 22046108 |
| [clinical study of safflower injection in treating and preventing the vascular crisis after free flap transplantation]. | to observe the clinical efficacy of safflower injection (al) in treating and preventing the vascular crisis after free flap transplantation. | 2011 | 22097197 |
| the expression of the hypoxia markers ca9 and cxcr4 is correlated with survival in patients with neuroendocrine tumours of the ileum. | background/aim: the hypoxia-inducible factor pathway regulates the expression of a diverse group of molecules such as ca9 and cxcr4. our aim was to investigate the expression of these markers in a series of patients with an ileal neuroendocrine tumour (iet) at various stages of tumorigenesis. methods: the immunohistochemical expression of ca9 and cxcr4 was examined in 51 patients with a resected iet. a 'hypoxic score' was calculated, integrating the expression of both ca9 and cxcr4 (hypoxic scor ... | 2011 | 22133596 |
| how type of parturition and health status influence hormonal and metabolic profiles in newborn foals. | thyroid hormones, insulin growth factor i (igf-i) and non-esterified fatty acids (nefa) represent important hormonal and metabolic factors associated with perinatal growth and maturation. their action could be influenced by the type of parturition and the health status of the foal and therefore the aim of this work is to evaluate their plasma concentrations in newborn foals during the first 2 wks of life. three groups of subjects were enrolled: 15 healthy foals born by spontaneous parturition, 2 ... | 2011 | 22153270 |
| [the expressions of alpha-enolase in the nasopharyngeal cancer tissue]. | to study the meaning of expressions of eno1 in the nasopharyngeal cancer tissue. | 2011 | 21950004 |
| real-time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging: preliminary results of a prospective study. | background: recently, a highly sensitive fluorescent imaging technique was developed for the real-time identification of hepatic tumors. the authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer. methods: forty-nine consecutive patients with pancreatic cancer who underwent surgical intervention were examined. preoperative clinical images had not revealed any hepatic metastases. on the day before surgery, indocyan ... | 2011 | 21990070 |
| metabonomic phenotyping reveals an embryotoxicity of deca-brominated diphenyl ether in mice. | recent studies have demonstrated that polybrominated diphenyl ethers (pbdes), a group of industrial chemicals, could disrupt thyroid hormone homeostasis and exhibit neurotoxicity, reproductive toxicity, and embryotoxicity. however, clear evidence of embryotoxicity and neurotoxicity of many of these congeners, such as deca-bde, one of the least bioactive congeners of pbdes, is still lacking. in the present study, we investigated deca-bde embryotoxicity by quantitative analysis of two essential th ... | 2011 | 21995789 |
| indications for staging laparoscopy in clinical t4m0 gastric cancer. | this study was undertaken to determine the efficacy of the clinical indications for performing staging laparoscopy for locally advanced gastric cancer to detect peritoneal metastasis or positive cytology findings. | 2011 | 21953130 |
| clinical evaluation of leukocyte filtration as an alternative anti-inflammatory strategy to aprotinin in high-risk patients undergoing coronary revascularization. | purpose: the use of aprotinin in cardiac surgery is associated with overriding safety concerns. therefore, there is increased research on alternatives. this study investigated the relative benefits of strategic leukofiltration on polymer-coated extracorporeal circuits (ecc), aprotinin, and combined therapy in high-risk patients. methods: eight hundred and seventy-five patients (euroscore 6+) undergoing coronary r ... | 2011 | 22068670 |
| previously unknown thyroid dysfunction in patients with acute ischemic stroke. | bengtsson d, brudin l, wanby p, carlsson m. previously unknown thyroid dysfunction in patients with acute ischemic stroke. acta neurol scand: doi: 10.1111/j.1600-0404.2011.01604.x. © 2011 john wiley & sons a/s. objectives - opinions differ regarding the clinical significance of subclinical thyroid disorders. the aim of the present study was to evaluate the prevalence and influence of previously unknown overt or subclinical thyroid dysfunction in patients with acute ischemic stroke and to look f ... | 2011 | 22034899 |
| sex steroid priming for induction of puberty in thalassemia patients with pulsatile reversible hypogonadotrophic hypogonadism. | growth and pubertal disturbances are the most common causes of morbidity, affecting 60-80% β-thalassemia major (β-tm) patients worldwide, due mainly to hypogonadotrophic hypogonadism (hh). we undertook a 6-year prospective study of 55 indian β-tm children with stunted growth and absent or arrested puberty, aged 15-18 years with pulsatile hh, to evaluate the role of low dose sex steroid priming (6-12 months) for physiological induction of puberty. eighty percent responded favorably with increase ... | 2011 | 22074126 |
| highly efficient dna compaction mediated by an in vivo antitumor-active tetrazolato-bridged dinuclear platinum(ii) complex. | we investigated the effects of antitumor-active tetrazolato-bridged dinuclear platinum(ii) complexes [{cis-pt(nh(3))(2)}(2)(μ-oh)(μ-tetrazolato-n(1),n(2))](2+) (1) and [{cis-pt(nh(3))(2)}(2)(μ-oh)(μ-tetrazolato-n(2),n(3))](2+) (2) on the higher-order structure of a large dna molecule (t4 phage dna, 166 kbp) in aqueous solution through single-molecule observation by fluorescence microscopy. complexes 1 and 2 cause irreversible compaction of dna through an intermediate state in which coil and comp ... | 2011 | 22004345 |
| advanced maxillary sinus cancer treated with concurrent chemoradiotherapy with intra-arterial cisplatin/docetaxel and oral s-1: own experience and literature review. | intra-arterial (ia) chemotherapy for head and neck cancer is effective and multiple ia concurrent chemoradiation (ccrt) protocols have been reported. however, the role of ia ccrt in the multimodality treatment of head and neck cancer is still controversial. we have treated 5 cases of unresectable t4 maxillary sinus squamous cell carcinoma with ia cisplatin (cddp) and docetaxel (doc) and ccrt with oral s-1. we report our experience and the effectiveness and feasibility of this combination as an a ... | 2011 | 22114575 |
| baseline trajectories of heavy drinking and their effects on postrandomization drinking in the combine study: empirically derived predictors of drinking outcomes during treatment. | the combined pharmacotherapies and behavioral interventions (combine) study sought to answer questions about the benefits of combining behavioral and pharmacological interventions (naltrexone and acamprosate) in alcohol-dependent patients. our goals were to identify trajectories of heavy drinking before randomization in combine, to characterize patients in these trajectories, and to assess whether prerandomization trajectories predict drinking outcomes. we analyzed daily indicators of heavy drin ... | 2011 | 21925828 |
| selenium, thiobarbituric acid reactive substances, and thyroid hormone activation in broilers supplemented with selenium as selenized yeast or sodium selenite. | the objective of this experiment was to compare the efficiencies of sodium selenite (ss) and selenized yeast (sy) supplemented at different doses (0.05 and 0.30 mg se/kg feed) with respect to plasma glutathione peroxidase (gpx) activity, extent of oxidative lipid injury, and thyroid hormone activation in broilers during the first four weeks of growth. results indicate a significant increase in plasma gpx activity and reduction in thiobarbituric acid reactive substances (tbars) in all supplemente ... | 2011 | 21977730 |
| biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer. | insulin-like growth factor 1 (igf-i), igf binding proteins (igfbp) 1 to 7, and c-peptide have been postulated to predict survival in non-small cell lung cancer (nsclc). studying serum levels in nsclc patients treated with surgical resection may provide information on the aggressiveness of tumors and be predictive of disease recurrence. | 2011 | 21945224 |
| [simultaneous relapse of basedow's disease in a patient with adult-onset still's disease]. | this report describes a 50-year-old woman with coexisting basedow's disease and adult-onset still's disease (aosd) that relapsed simultaneously. she was diagnosed with basedow's disease in 1999, and treatment with antithyroid agents was started. however, the treatment was soon stopped because of severe side effects. a partial thyroidectomy was performed and the thyroid function stayed well-controlled after the surgery. in august 2007, she was admitted to our hospital with fever, a sore throat, s ... | 2011 | 22041431 |
| comparison of s100β levels, and their correlation with hemodynamic indices in patients undergoing coronary artery bypass grafting with three different anesthetic techniques. | cardiac surgery with aid of cardiopulmonary bypass (cpb) is associated with neurological dysfunction. the presence of cerebrospecific protein s100β in serum is an indicator of cerebral damage. this study was designed to evaluate the influence of three different anesthesia techniques, on s100β levels, in patients undergoing coronary artery bypass grafting on cpb. a total of 180 patients were divided into three groups - each of who received sevoflurane, isoflurane and total intravenous anesthesia ... | 2011 | 21860192 |
| lumbo-pelvic lordosis and the pelvic radius technique in the assessment of spinal sagittal balance: strengths and caveats. | the two main methodologies described for the assessment of spinal sagittal alignment are the pelvic radius (pr) technique and that based on measures of the pelvic incidence (pi) and spino-sacral angle (ssa). both methods stress the fundamental relationship between the anatomical position and orientation of the sacrum within the pelvis and the spinal curves above. the aim of the current study was to assess the strengths and potential weaknesses of the pr technique. the pr technique uses measures ... | 2011 | 21863464 |
| l-alanyl-glutamine pretreatment attenuates acute inflammatory response in children submitted to palatoplasty. | to evaluate the effects of l-alanyl-glutamine (l-ala-gln) pretreatment on oxidative stress, glycemic control and inflammatory response in children submitted to palatoplasty. | 2011 | 21971662 |
| longitudinal assessment of periodontal status in patients with nickel allergy treated with conventional and nickel-free braces. | abstract objective: to perform a longitudinal comparison of periodontal status in allergic individuals treated with conventional and nickel-free braces. materials and methods: forty-two individuals allergic to nickel were randomly divided into two groups: those receiving conventional braces (n = 21) and those receiving nickel-free braces (n = 21). periodontal status (gingival hyperplasia, change in color and bleeding) was assessed before treatment (t0) and at 3-month intervals ... | 2011 | 22044116 |
| health-related quality of life in patients with high-risk melanoma randomised in the nordic phase 3 trial with adjuvant intermediate-dose interferon alfa-2b. | purpose: to compare health-related quality of life (hrqol) and side-effects in patients with high-risk melanoma participating in a randomised phase iii trial of adjuvant interferon alfa-2b (ifn). patients and methods: a total of 855 patients with histologically verified resected cutaneous melanoma in ajcc stage iib (t4 n0 m0) or stage iii (tx n1-3 m0) were randomised to: arm a: observation only (n=284); arm b: 1-year treatment: induction: ifn alfa-2b, 10 mu (flat dose), sc, 5days/week, 4weeks, m ... | 2011 | 22196968 |
| in situ stabilization of trace metals in a copper-contaminated soil using p-spiked linz-donawitz slag. | purpose: a former wood exploitation revealing high cu and as concentration of the soils served as a case study for assisted phytoextraction. method: p-spiked linz-donawitz (ld) slag was used as a soil additive to improve physico-chemical soil properties and in situ stabilize cu and other trace metals in a sandy cu-contaminated soil (630 mg kg(-1) soil). the ld slag was incorporated into the contaminated soil to c ... | 2011 | 21948144 |
| 5'cag and 5'ctg repeats create differential impediment to the progression of a minimal reconstituted t4 replisome depending on the concentration of dntps. | instability of repetitive sequences originates from strand misalignment during repair or replicative dna synthesis. to investigate the activity of reconstituted t4 replisomes across trinucleotide repeats (tnrs) during leading strand dna synthesis, we developed a method to build replication miniforks containing a tnr unit of defined sequence and length. each minifork consists of three strands, primer, leading strand template, and lagging strand template with a 5' single-stranded (ss) tail. each s ... | 2011 | 22096622 |
| [Overgrowth with and without obesity: clinical and molecular principles.] | Somatic overgrowth is a complex and heterogeneous pathology that is only partially understood, although developments in molecular biology have allowed the discovery of the aetiological basis of some of these conditions. The differential diagnosis of a patient with a possible variant of normality, a chromosomopathy, a dysmorphic syndrome, a metabolic or an endocrine disease is essential. The initial clinical evaluation should include a correct anamnesis and physical examination, as well as comple ... | 2011 | 22098786 |
| tai chi () pedicle screw placement for severe scoliosis. | study design:: retrospective. objective:: to evaluate the clinical safety and accuracy of the tai chi () technique for placing pedicle screws, without intraoperative radiographic imaging, in severe scoliotic spines. summary of background data:: the current techniques for pedicle screw placement have a number of drawbacks in cases of severe scoliosis, including difficulty or impossibility to use, delayed operative time, requiring the presence of trained personnel for the duration of the surgery, ... | 2011 | 22124422 |
| successful treatment of a t4 lung tumor with vertebral body invasion using fiducial markers in the thoracic spine for image-guided radiation therapy: a case report. | abstract: | 2011 | 21933408 |
| contribution of bacterial outer membrane vesicles to innate bacterial defense. | abstract: | 2011 | 22133164 |
| the ribosome modulates nascent protein folding. | proteins are synthesized by the ribosome and generally must fold to become functionally active. although it is commonly assumed that the ribosome affects the folding process, this idea has been extremely difficult to demonstrate. we have developed an experimental system to investigate the folding of single ribosome-bound stalled nascent polypeptides with optical tweezers. in t4 lysozyme, synthesized in a reconstituted in vitro translation system, the ribosome slows the formation of stable tertia ... | 2011 | 22194581 |
| Long-Term Outcomes Following Vocational Rehabilitation Treatments in Patients with Prolonged Fatigue. | BACKGROUND: Multi-component vocational rehabilitation (VR) provides positive short-term outcomes in patients with prolonged fatigue. PURPOSE: The purpose of this study is to evaluate the long-term outcomes of Dutch multi-component VR up to 18 months after treatment. METHOD: In a pre-post-study, measurements were taken before treatment (t0), after treat ... | 2011 | 22135188 |
| hypothyroidism presenting with recurrent pericardial tamponade. | we present a case of pericardial tamponade caused by hypothyroidism. a 66-year-old man presented with acute chest pain radiating to the back. computed tomography ruled out an aortic dissection but revealed a large pericardial effusion, which was confirmed on transthoracic echocardiography showing features of tamponade. the effusion was drained and subsequent thyroid function tests showed profound hypothyroidism. no other cause of the pericardial effusion could be identified. despite the prompt i ... | 2009 | 22132022 |
| locally advanced colorectal cancer: results of surgical treatment and prognostic factors. | to evaluate the incidence surgical results and prognostic factors of locally advanced colorectal cancer. | 2011 | 22147133 |
| Association between genetic variants in glutathione peroxidase 1 (GPx1) gene, GPx activity and the risk of prostate cancer. | The aim of this study was to investigate the association between GPx1 Pro198Leu polymorphism with the development and progression of prostate cancer (PCa) and evaluate whether smoking status and advanced age could modify this association. | 2011 | 21993316 |
| An approach to crystallizing proteins by metal-mediated synthetic symmetrization. | Combining the concepts of synthetic symmetrization with the approach of engineering metal-binding sites, we have developed a new crystallization methodology termed metal-mediated synthetic symmetrization. In this method, pairs of histidine or cysteine mutations are introduced on the surface of target proteins, generating crystal lattice contacts or oligomeric assemblies upon coordination with metal. Metal-mediated synthetic symmetrization greatly expands the packing and oligomeric assembly possi ... | 2011 | 21898649 |
| the effect of anesthetic techniques on neutrophil-to-lymphocyte ratio after laparoscopy-assisted vaginal hysterectomy. | surgical stress can induce postoperative systemic leukocytic alterations, including leukocytosis, neutrophilia, or lymphopenia. the present study investigated whether the anesthetic technique could affect the leukocytic alterations, including neutrophil-to-lymphocyte (n/l) ratio, after gynecologic laparoscopy. | 2011 | 21982167 |
| evaluation of a pharmacist-managed amiodarone monitoring program. | because of the potential for serious adverse effects, patients treated with amiodarone must be carefully screened and routinely monitored for potential liver, thyroid, and pulmonary toxicity. however, laboratory and pulmonary monitoring rates have been found to be substantially lower than recommended in guidelines, including those of the north american society of pacing and electrophysiology (naspe, 2007). | 2011 | 21870892 |
| using an advanced radiation therapy technique for t4 squamous cell carcinoma of the face. | patients with locally advanced skin cancer often present an uncommon and unique treatment challenge. surgical resection and reconstruction with an acceptable cosmetic outcome is difficult for larger lesions with deep infiltration into subcutaneous tissues. radiation therapy has been shown to be an effective treatment modality for advanced non-melanoma skin cancers, with cure rates ranging 50-100%. in this case report, we discuss the efficacy and outcome of treatment using an advanced radiation t ... | 2010 | 21886750 |
| thyroid hormonal disturbances related to treatment of hepatitis c with interferon-alpha and ribavirin. | to characterize thyroid disturbances induced by interferon-alpha and ribavirin therapy in patients with chronic hepatitis c. | 2011 | 22012048 |
| Determinants of the cytotoxicity of PrrC anticodon nuclease and its amelioration by tRNA repair. | Breakage of tRNA(Lys(UUU)) by the Escherichia coli anticodon nuclease PrrC (EcoPrrC) underlies a host antiviral response to phage T4 infection that is ultimately thwarted by a virus-encoded RNA repair system. PrrC homologs are prevalent in other bacteria, but their activities and substrates are not defined. We find that induced expression of EcoPrrC is toxic in Saccharomyces cerevisiae and E. coli, whereas the Neisseria meningitidis PrrC (NmePrrC) is not. PrrCs consist of an N-terminal NTPase mo ... | 2012 | 22101242 |
| accuracy of multi-detector computed tomography (mdct) in staging of renal cell carcinoma (rcc): analysis of risk factors for mis-staging and its impact on surgical intervention. | objectives: to assess the accuracy of multi-detector computed tomography (mdct) in preoperative staging of renal cell carcinoma (rcc) and to detect the possible risk factors for mis-staging. in addition, the impact of radiological mis-staging on surgical decision and operative procedures was evaluated. materials and methods: data files of 693 patients, who underwent either radical or partial nephrectomy after pre ... | 2011 | 22200936 |
| peer victimization, depressive symptoms, and high salivary cortisol predict poorer memory in children. | the predictive relations of peer victimization, depressive symptoms, and salivary cortisol on memory in 168 children aged 12 at time 1 (t1) were examined using a longitudinal design in which data were collected on four occasions over a 2-year period. results indicated that: (1) peer victimization, depressive symptoms, and evening cortisol were stable over time, (2) peer victimization and elevated symptoms of depression were concurrently linked at each time, (3) t1 peer victimization predicted el ... | 2011 | 21855200 |
| Substance use and delinquency among middle school girls in foster care: A three-year follow-up of a randomized controlled trial. | Objective: The present study evaluated the efficacy of the Middle School Success intervention (MSS) for reducing substance use and delinquency among girls in foster care, using a randomized controlled trial design. The program was designed to fill a service gap during the summer prior to the middle school transition and to prevent delinquency, substance use, and related problems. Method: One hundred girls in foster care and their caregivers were randomly assigned either to the intervention (n = ... | 2011 | 22004305 |
| preoperative evaluation of the depth of anal canal invasion in very low rectal cancer by magnetic resonance imaging and surgical indications for intersphincteric resection. | purpose: the present study was performed to evaluate the depth of anal canal invasion (daci), and determine whether magnetic resonance imaging (mri) assessment of the conjoined longitudinal muscle (clm) can be used to identify the surgical indication for intersphincteric resection. methods: sixty-six patients with t1 (n = 2), t2 (n = 20), t3 (n = 39), and t4 (n = 5) lower rectal cancer were included. depth of ana ... | 2011 | 22075666 |
| The accuracy of clinical kyphosis examination for detection of thoracic vertebral fractures: comparison of direct and indirect kyphosis measures. | To compare the accuracies of two simple physical examination maneuvers for detecting the presence of thoracic vertebral fractures (VF) diagnosed by radiography: direct measurement of kyphosis angle (KA, in degrees) and indirect measurement using wall-occiput distance (WOD, in cm). | 2011 | 21885900 |
| A phase III trial of docetaxel-estramustine in high-risk localised prostate cancer: A planned analysis of response, toxicity and quality of life in the GETUG 12 trial. | To assess docetaxel-estramustine in patients with localised high-risk prostate cancer. | 2012 | 22119204 |
| a review on the metabolic disorders of iodine deficiency. | iodine is in the crucial parts of two hormones of t4 and t3 produced by the thyroid glands which are essential for all the aspects of human metabolisms. it is demonstrated that iodine deficiency can be considered as sole cause of many thyroid abnormalities including mental disorders. iodine deficiency of sufficient degree to cause hypothyroidism during fetus life and early infancy will be accompanied with brain abnormality possibly to the stage of mental retardation. the iodine deficiency among ... | 2011 | 21902053 |
| Thyroid diseases in elderly. | Thyroid diseases are the commonest endocrine disorders in the general population. In most of the cases, they are consistent with benign conditions which may be asymptomatic or affect people at a variable extent. Since they often represent chronic conditions their prevalence increases by age and reaches in elderly the highest rates. Thyroid nodules are a common clinical finding. Most subjects with thyroid nodules have few or no symptoms. Thyroid nodules are more commonly non-functioning. However, ... | 2011 | 22019751 |
| Condensation silicones: do new materials really presents better dimensional stability? | The aim of this study was evaluate the dimensional stability of some condensation silicones. The following materials were studied: Coltex/Coltoflax - Coltène, Speedex - Coltène, and Optosil Comfort/Xantopren VL Plus - Kulzer. They were evaluated by dimensional analysis and gas chromatography (GC) performed at the following times: T0, T1, T2, T3, T4, and T5 (immediately after setting, thirty minutes, two hours, twenty four hours, seventy two hours, and seven days after setting, respectively). The ... | 2011 | 22010408 |
| short course chemotherapy followed by concomitant chemoradiotherapy and surgery in locally advanced rectal cancer: a randomized multicentric phase ii study. | background: induction chemotherapy has been suggested to impact on preoperative chemoradiation efficacy in locally advanced rectal cancer (larc). to evaluate in larc patients, the feasibility and efficacy of a short intense course of induction oxaliplatin before preoperative chemoradiotherapy (crt). patients and methods: patients with t2-t4/n+ rectal adenocarcinoma were randomly assigned to arm a-preoperative crt with 5-fluorouracil (5-fu) continuous infusion followed by surgery-or arm b-induc ... | 2011 | 22039087 |
| [multimodal therapy for colon cancer: state of the art]. | in uicc stage i a selected group of patients with t1 tumours and a low risk profile regarding simultaneous lymph node metastases can be treated by endoscopic resection alone, if the tumour is thereby completely removed. in uicc stage ii an adjuvant chemotherapy (ct) should not be routinely performed. however, in high risk uicc stage ii patients (t4 tumour, less than 12 examined lymph nodes, emergency surgery, intraoperative tumour perforation), an adjuvant ct with infusional 5-fu/fa should be re ... | 2011 | 21863510 |
| Comparison of endocrine-mediated effects of two bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4'-cyclohexylidenebisphenol, based on subacute oral toxicity studies using rats. | The purpose of this study was to compare endocrine-mediated effects of bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4'-cyclohexylidenebisphenol with reference to OECD Test Guideline No. 407. Rats were orally gavaged with 0, 4, 20, and 100mg/kg/day of 2,2-bis(4-cyanatophyenyl)propane, and 0, 30, 100, and 300mg/kg/day of 4,4'-cyclohexylidenebisphenol for at least 28 days beginning at 8 weeks of age. Endocrine-mediated effects were not observed in rats given 2,2-bis(4-cyana ... | 2012 | 22093917 |
| bacteriophage t4 mota activator and the β-flap tip of rna polymerase target the same set of σ70 carboxyl-terminal residues. | sigma factors, the specificity subunits of rna polymerase, are involved in interactions with promoter dna, the core subunits of rna polymerase, and transcription factors. the bacteriophage t4-encoded activator, mota, is one such factor, which engages the c terminus of the escherichia coli housekeeping sigma factor, σ(70). mota functions in concert with a phage-encoded co-activator, asia, as a molecular switch. this process, termed sigma appropriation, inhibits host transcription while activating ... | 2011 | 21911499 |