Publications

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identification of gastric cancer risk markers that are informative in individuals with past h. pylori infection.background: epigenomic damage induced by helicobacter pylori infection is accumulated in gastric mucosae before the development of malignancy. in individuals without current h. pylori infection, dna methylation levels of specific cpg islands (cgis) are associated with gastric cancer risk. because risk estimation in individuals with past infection is clinically important, we here aimed to identify the risk markers that reflect epigenomic damage induced by h. pylori infection ...201222237657
helicobacter pylori infection is strongly associated with gastric and duodenal ulcers in a large prospective study.background & aims: infection with helicobacter pylori is a risk factor for peptic ulcer disease (pud), but there is limited longitudinal data on the associations between infection and incident gastric or duodenal ulcers. methods: information on potential risk factors, life-time history of pud, and serologic measurements of h pylori infection were obtained from a german cohort of 9953 adults, 50-74 years old at baseline (2000-2002). the incidence of ulcers was determined by questionnaires sent to ...201222230167
potential infectious etiology of behçet's disease.behçet's disease is a multisystem inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. the cause of behçet's disease remains unknown, but epidemiologic findings suggest that an autoimmune process is triggered by an environmental agent in a genetically predisposed individual. an infectious agent could operate through molecular mimicry, and subsequently the disease could be perpetuated by an abnormal immune response to an autoantigen in ...201222254152
gastric cancer development after helicobacter pylori eradication therapy: a new form of gastric neoplasia.background and aim: along with the widespread use of eradication for helicobacter pylori (h. pylori), the incidence of gastric cancer after eradication has also been increasing. there is a need for clarification of the clinical and biological characteristics of these neoplasms. patients and methods: we studied 27 cases of gastric cancer that developed after eradication (group ae). out of the 27, we selected 26 with early-stage gastric cancer and compared them with 78 age-matched gastric cancer p ...201222223100
the use of albumax ii(®) as a blood or serum alternative for the culture of helicobacter pylori.background:  growth of helicobacter pyloriin vitro depends on supplementation of the medium with blood or serum. however, these supplements often require frozen storage and can show batch-to-batch variation, resulting in differences in bacterial growth. in this study, we introduce the use of a commercially available, lipid-rich supplement called albumax ii(®) (gibco brl, grand island, ny, usa) for use as a serum/blood replacement for h. pylori culture. materials and methods:  the growth of h. p ...201222221619
prevention of gastric cancer by eradicating helicobacter pylori. 201222222244
increased numbers of foxp3-positive regulatory t cells in gastritis, peptic ulcer and gastric adenocarcinoma.to determine the number of regulatory t cells (tregs) in gastric mucosa of patients with gastritis, peptic ulcers and gastric cancer.201222228968
paediatric halitosis and helicobacter pylori infection.objective: to compare the presence of helicobacter pylori (h. pylori) infection by stool antigen test in children with and without halitosis. study design: comparative study. place and duration of study: department of paediatrics, fatih university hospital, ankara, turkey, between december 2008 and june 2009. methodology: fifty-three patients aged between 3-15 years who presented to paediatrics outpatient clinic with halitosis and 55 healthy children aged between 4-15 years without halitosis wer ...201222237186
effects of interleukin-10 polymorphisms, helicobacter pylori infection, and smoking on the risk of noncardia gastric cancer.both variations in the interleukin-10 (il10) gene and environmental factors are thought to influence inflammation and gastric carcinogenesis. therefore, we investigated the associations between il10 polymorphisms, helicobacter pylori (h. pylori) infection, and smoking in noncardia gastric carcinogenesis in koreans.201222235320
evaluation of the clinical relevance of hrga gene in patients with helicobacter pylori infection.background/aims: patients with gastric cancer in some asian populations were infected more frequently with hrga-positive h. pylori. the aim of this study was to examine the usefulness of hrga to predict the clinical outcome of h. pylori infection. methodology: fortyfour patients with gastric cancer (35 intestinal and 9 diffuse type cancer) and 51 control subjects were studied. presence of hrga gene in h. pylori strains isolated from biopsy specimens was examined by pcr. biopsy specimens were als ...201222251550
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