| upper gastrointestinal bleedings in patients with hereditary coagulation disorders in northwest of iran: prevalence of helicobacter pylori infection. | upper gastrointestinal (ugi) bleeding is one of the most life-threatening complications, in up to 25% of persons with hemophilia (pwh). recurrent bleeding is common and can be caused by the helicobacter pylori infection. our aim was to evaluate the role of h. pylori infection in ugi bleeding in pwh. | 2011 | 21904206 |
| helicobacter pylori antibiotic resistance in brazil: clarithromycin is still a good option. | the antibiotic susceptibility is the cornerstone for the eradication therapies of helicobacter pylori. | 2011 | 22147131 |
| Gastric and duodenum microflora analysis after long-term Helicobacter pylori infection in Mongolian Gerbils. | Long-term Helicobacter pylori infection leads to chronic gastritis, peptic ulcer, and gastric malignancies. Indigenous microflora in alimentary tract maintains a colonization barrier against pathogenic microorganisms. This study is aimed to observe the gastric and duodenum microflora alteration after H. pylori infection in Mongolian Gerbils model. | 2011 | 21923685 |
| gastrointestinal immune system and brain dialogue implicated in neuroinflammatory and neurodegenerative diseases. | a common characteristic of the central nervous system (cns) neurodegenerative disorders is neuroinflammation, marked by augmented numbers of activated and primed microglia, increased inflammatory cytokines and decreased anti-inflammatory molecules. cns neuroinflammation is a critical component in the progression of several neurodegenerative diseases which sensitize the brain to produce an exaggerated response to immune stimuli in the periphery. neuroinflammation might initiate from the periphery ... | 2011 | 21902649 |
| induction of cd69 expression by cagpai-positive helicobacter pylori infection. | to investigate and elucidate the molecular mechanism that regulates inducible expression of cd69 by helicobacter pylori (h. pylori) infection. | 2011 | 21990950 |
| Male Gender, Hiatus Hernia and Helicobacter Pylori Infection Associated with Asymptomatic Erosive Esophagitis. | Background and Aims: Asymptomatic erosive esophagitis (AEE) is an easily forgotten subgroup of gastroesophageal reflux disease (GERD) due to it's lack of warning symptoms despite having the risk of developing complications such as bleeding, stricture or even esophageal adenocarcinoma. Materials and Methods: A total of 2843 potentially eligible subjects were screened at the health management center of Buddhist Tzu Chi General Hospital. 1002 subjects responded to this survey and gave informed cons ... | 2011 | 21871022 |
| complete genome sequence of "candidatus tremblaya princeps" strain pcval, an intriguing translational machine below the living-cell status. | the sequence of the genome of "candidatus tremblaya princeps" strain pcval, the primary endosymbiont of the citrus mealybug planococcus citri, has been determined. "ca. tremblaya princeps" presents an unusual nested endosymbiosis and harbors a gammaproteobacterial symbiont within its cytoplasm in all analyzed mealybugs. the genome sequence reveals that "ca. tremblaya princeps" cannot be considered an independent organism but that the consortium with its gammaproteobacterial symbiotic associate r ... | 2011 | 21914892 |
| expansion of european vaca and caga alleles to east-asian helicobacter pylori strains in cambodia. | helicobacter pylori infection is associated with gastric cancer (gc). the highest incidence rates have been described in asia, but regional variations exist that do not match the distribution of infection prevalence rates. the aim of the study was to examine the possible contribution of h. pylori virulence factors to geographic differences in the incidence of gc across east and southeast asia. we studied 66 isolates from cambodian patients that had previously been assigned to two genetic populat ... | 2011 | 21871583 |
| effect of endoscopic screening at 1-year intervals on the clinicopathologic characteristics and treatment of gastric cancer in south korea. | background and aim: the recommended interval of endoscopic screening for gastric cancer (gc) in a general population is 2 years in korea. however, it has not been determined whether endoscopic screening with a shorter interval is beneficial, especially for high-risk groups. methods: a total of 415 patients with gc were categorized according to whether they had (vigilant screening group) or not (non-vigilant screening group) undergone endoscopic screening within 1 year before being diagnosed with ... | 2011 | 22142434 |
| New urea biosensor based on urease enzyme obtained from Helycobacter pylori. | The urease enzyme of Helicobacter pylori was isolated from biopsy sample obtained from antrum big curvature cell extracts. A new urea biosensor was prepared by immobilizing urease enzyme isolated from Helicobacter pylori on poly(vinylchloride) (PVC) ammonium membrane electrode by using nonactine as an ammonium ionophore. The effect of pH, buffer concentration, and temperature for the biosensor prepared with urease from H. pylori were obtained as 6.0, 5 mM, and 25 °C, respectively. We also invest ... | 2011 | 21881954 |
| Helicobacter pylori and nonmalignant diseases. | Research published over the past year has documented the continued decline of Helicobacter pylori-related peptic ulcer disease and increased recognition of non-H. pylori, non-steroidal anti-inflammatory drugs ulcer disease--idiopathic ulcers. Despite reduced prevalence of uncomplicated PUD, rates of ulcer complications and associated mortality remain stubbornly high. The role of H. pylori in functional dyspepsia is unclear, with some authors considering H. pylori-associated nonulcer dyspepsia a ... | 2011 | 21896083 |
| A new look at anti-Helicobacter pylori therapy. | With the rising prevalence of antimicrobial resistance, the treatment success of standard triple therapy has recently declined to unacceptable levels (i.e., 80% or less) in most countries. Therefore, several treatment regimens have emerged to cure Helicobacter pylori (H. pylori) infection. Novel first-line anti-H. pylori therapies in 2011 include sequential therapy, concomitant quadruple therapy, hybrid (dual-concomitant) therapy and bismuth-containing quadruple therapy. After the failure of sta ... | 2011 | 22046084 |
| modulation of the cd4+ t-cell response by helicobacter pylori depends on known virulence factors and bacterial cholesterol and cholesterol α-glucoside content. | helicobacter pylori blocks the proliferation of human cd4(+) t cells, facilitated by vacuolating exotoxin (vaca) and γ-glutamyl transpeptidase (ggt). h. pylori-triggered t-cell reactions in mice correlate with bacterial cholesterol and cholesterol α-glucoside content but their role in human cells is unclear. we characterized the effect of vaca, ggt, and cholesterol on t-helper 1, t-helper 2, t-regulatory and t-helper 17 associated cytokines and t-cell proliferation. vaca, ggt, and bacterial chol ... | 2011 | 21921201 |
| Genetic Markers for Rapid PCR-Based Identification of Gull, Canada Goose, Duck, and Chicken Fecal Contamination in Water. | Avian feces contaminate waterways but contribute fewer human pathogens than human sources. Rapid identification and quantification of avian contamination would therefore be useful to prevent overestimation of human health risk. We used subtractive hybridization of PCR-amplified gull fecal 16S RNA genes to identify avian-specific fecal rRNA gene sequences. The subtracters were rRNA genes amplified from human, dog, cat, cow, and pig feces. Recovered sequences were related to Enterobacteriaceae (47 ... | 2012 | 22081573 |
| Helicobacter pylori Has an Inverse Relationship With Severity of Reflux Esophagitis. | | 2011 | 21860812 |
| helicobacter pylori and autoimmune diseases. | helicobacter pylori (h. pylori) is a widely prevalent microbe, with between 50 and 80% of the population infected worldwide. clinically, infection with h. pylori is commonly associated with peptic ulcer disease, but many of those infected remain asymptomatic. h. pylori has evolved a number of means to affect the host immune response and has been implicated in many diseases mitigated by immune dysregulation, such as immune thrombocytopenic purpura (itp), atrophic gastritis, and mucosa associated ... | 2011 | 21902767 |
| The Intact dupA Cluster Is a More Reliable Helicobacter pylori Virulence Marker than dupA Alone. | The duodenal ulcer promoting (dupA) gene, located in the plasticity region of Helicobacter pylori, is associated with duodenal ulcer development. dupA was predicted to form a type IV secretory system (T4SS) with vir genes around dupA (dupA cluster). We investigated the prevalence of dupA and dupA clusters and clarified associations between the dupA cluster status and clinical outcomes in the U.S. population. In all, 245 H. pylori strains were examined using PCR to evaluate the status of dupA and ... | 2012 | 22038914 |
| Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma. | The increasing therapeutic failures against Helicobacter pylori infection has determined the need to develop new drugs. The susceptibility to resveratrol (1) of twenty-six H. pylori strains representing nine CagA+ strains from patients with gastric carcinoma and eight CagA- and nine CagA+ strains from patients with chronic gastritis only was evaluated. Compound 1 was dissolved in DMSO and double diluted in Brucella broth with 10% BFS; ca. 10(6) organisms were added to each dilution. After incuba ... | 2011 | 21936484 |
| Tumor biomarker glycoproteins in the seminal plasma of healthy human males are endogenous ligands for DC-SIGN. | DC-SIGN is an immune C-type lectin that is expressed on both immature and mature dendritic cells associated with peripheral and lymphoid tissues in humans. It is a pattern recognition receptor that binds to several pathogens including HIV-1, Ebola virus, Mycobacterium tuberculosis, Candida albicans, Helicobacter pylori, and Schistosoma mansoni. Evidence is now mounting that DC-SIGN also recognizes endogenous glycoproteins, and that such interactions play a major role in maintaining immune homeo ... | 2011 | 21986992 |
| Heme iron from meat and risk of adenocarcinoma of the esophagus and stomach. | Iron can cause oxidative stress and DNA damage, and heme iron can catalyze endogenous formation of N-nitroso compounds, which are potent carcinogens. Dietary iron promotes esophageal cancer incidence in animal studies and has been identified as a growth factor for Helicobacter pylori, an established risk factor for stomach cancer. We conducted a population-based case-control study of adenocarcinoma of the esophagus (n=124) and stomach (n=154) and 449 controls in Nebraska. Heme iron and total iro ... | 2011 | 22044848 |
| Distribution of Spontaneous gyrA Mutations in 97 Fluoroquinolone-Resistant Helicobacter pylori Isolates Collected in France. | We determined the prevalence of gyrA mutations conferring fluoroquinolone resistance in 97 Helicobacter pylori isolates collected in France from 2007 to 2010. Ninety-four harbored one or two mutations already found in the quinolone resistance determining region (QRDR) of gyrA (for T87I, n = 23; for N87K, n = 32; for D91N, n = 30; for D91G, n = 7; for D91Y, n = 6), 2 harbored a mutation never previously described (D91H and A88P), and one strain was resistant (ciprofloxacin MIC of 8 mg/liter) with ... | 2012 | 22064536 |
| Immunosuppressive proteins isolated from spiral and coccoid cytoplasmic solutions of Helicobacter pylori. | The aim of this study was to investigate the antiproliferative proteins that probably have a role in Helicobacter pylori evade of immune response and cause chronic infection disease and also to see if coccoid form had a role in its chronicity. H. pylori strain VacA s2/m2 positive and CagA negative, from a gastric biopsy of a patient with peptic ulcer disease, was isolated and cultured in brucella agar. Both spiral and coccoid forms were harvested and ruptured by sonication. The cytoplasmic solut ... | 2011 | 21916264 |
| Correlation between creatinine clearance and Helicobacter pylori infection eradication with sequential and triple therapeutic regimens: A randomised clinical trial. | Uraemic patients show susceptibility to gastrointestinal mucosal lesions and colonisation by Helicobacter pylori (HP). Antibiotic resistance constitutes a problem in treatment and bismuth preparations are toxic in uraemic patients. This study aimed to assess the correlation between creatinine clearance (CrCl) and eradication of HP infection with new sequential and standard triple therapeutic regimens. | 2011 | 22055594 |
| Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians. | Several polymorphisms of genes involved in the immunological recognition of Helicobacter pylori and regulating apoptosis and proliferation have been linked to gastric carcinogenesis, however reported data are partially conflicting. The aim of our study was to evaluate potential associations between the presence of gastric cancer (GC) and high risk atrophic gastritis (HRAG) and polymorphisms of genes encoding Angiotensin converting enzyme (ACE), Nod-like receptor 1 (NOD1), Toll-like receptor 4 (T ... | 2011 | 21864388 |
| Gastric Cancers Emerging after H. pylori Eradication Arise Exclusively from Non-Acid-Secreting Areas. | Although Helicobacter pylori (H. pylori) eradication has some inhibitory effects on the subsequent development of gastric cancer, there are sporadic cases of gastric cancer even after successful eradication. The pathogenesis of gastric cancer emerging after H. pylori eradication remains to be clarified. In this study, employing Congo-red chromoendoscopy, which is capable of visualizing the acid-secreting fundic mucosa, we investigated the topographic relationship of the acid secretion pattern ... | 2012 | 22186036 |
| [helicobacter pylori: routes of transmission of infection (a review of literature)]. | the paper reviews the data characterizing the routes of transmission of helicobacter pylori. particular emphasis is laid on the water transmission route that has not been long considered to be important despite strong epidemiological evidence that allows it to be regarded as one of the most important routes of transmission of this infection. it describes the most favorable conditions for this microorganism to survive in the water systems, including plumbing, and a possible survival mechanism via ... | 2011 | 21899098 |
| Iron trafficking system in Helicobacter pylori. | Helicobacter pylori infections are closely associated with peptic ulcers, gastric malignancy and iron deficiency anemia. Iron is essential for almost all living organisms and the investigation of iron uptake and trafficking system is thus important to understand the pathological roles of H. pylori. Up to now, the iron trafficking system of H. pylori is not yet fully clear and merits further efforts in this regards. The available information about iron uptake and regulation has been discussed in ... | 2011 | 22127376 |
| Why is Helicobacter pylori disappearing? More questions than answers. | | 2011 | 22011710 |
| Order and disorder in large multi-site docking proteins of the Gab family-implications for signalling complex formation and inhibitor design strategies. | Large multi-site docking (LMD) proteins of the Gab, IRS, FRS, DOK and Cas families consist of one or two folded N-terminal domains, followed by a predominantly disordered C-terminal extension. Their primary function is to provide a docking platform for signalling molecules (including PI3K, PLC, Grb2, Crk, RasGAP, SHP2) in intracellular signal transmission from activated cell-surface receptors, to which they become coupled. A detailed analysis of the structural nature and intrinsic disorder prope ... | 2012 | 21935523 |
| Relationship between the Extent of DNA Damage and Gastritis in Normal and Helicobacter pylori-Infected Patients. | The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. pylori infection is thought to predispose carriers to gastric cancer. The aim of this study was to investigate the relationship between the extent of DNA damage in normal gastric epithelial cells and H. pylori-positive and -negative gastritis according to histological diagnosis. We also compared the percentage of cometed cells on the surface of the gastric epithelial cells to the percentage beneath the gastric mucosal c ... | 2011 | 21927660 |
| Chemical Constituents of the Methanolic Extract of Leaves of Leiothrix spiralis Ruhland and Their Antimicrobial Activity. | Chemical fractionation of the methanolic extract of leaves of Leiothrix spiralis Ruhland afforded the flavonoids luteolin-6-C-b-D-glucopyranoside (1), 7-methoxyluteolin-6-C-b-D-glucopyranoside (2), 7-methoxyluteolin-8-C-b-D-glucopyranoside (3), 4'-methoxyluteolin-6-C-b-D-glucopyranoside (4), and 6-hydroxy-7-methoxyluteolin (5), and the xanthones 8-carboxymethyl-1,5,6-trihydroxy-3-methoxyxanthone (6), 8-carboxy-methyl-1,3,5,6-tetrahydroxyxanthone (7). Methanolic extract, fractions, and isolated c ... | 2011 | 22179427 |
| helicobacter pylori-negative gastric cancer in south korea: incidence and clinicopathologic characteristics. | it is difficult to determine the exact incidence rate of helicobacter pylori (h. pylori) infection-negative gastric cancer (hpin-gc) because h. pylori detection rates decrease with the progression of gastric atrophy and intestinal metaplasia. the aim of this study was to evaluate the incidence and clinicopathologic characteristics of hpin-gc in south korea. | 2011 | 21923684 |
| Endoscopic versus histological diagnosis of Barrett's esophagus: a cross-sectional survey. | Context : Barrett's esophagus is a common pathological condition in patients with gastro-esophageal reflux disease. Objective : The aim of this study was to compare endoscopic diagnosis versus histological confirmation. Design : Cross-sectional. Setting: Cancer Institute of the Imam Khomeini Hospital. Material and methods : A total of 50 patients with a history of gastro-esophageal reflux were recruited and underwent upper endoscopy at this cross-sectional survey. Four-quadrant biopsy was tak ... | 2011 | 22102072 |
| the role of the renin-angiotensin system in gastric oncogenesis. | the renin-angiotensin system (ras) plays an important role not only in homeostasis but also in carcinogenesis. recent epidemiological studies suggest that hypertensive patients with up-regulated systemic ras functions are at a significantly increased risk for the subsequent development of cancers with poor outcomes, and moreover that ras inhibitors reduce tumor development, progression, and metastasis. notably, helicobacter pylori infection, one of the major predictors of gastric carcinogenesis, ... | 2011 | 22114933 |
| The association between Helicobacter Pylori chronic gastritis, psychological trauma and somatization disorder. A case report. | Helicobacter Pylori is considered to be the agent responsible for peptic ulcers and gastritis, and its eradication represents a main objective in the treatment of digestive diseases. We present the case report of a female patient diagnosed with chronic Helicobacter Pylori infection, where symptoms manifested after the patient was raped. In the context of psychological trauma, digestive manifestations such as ulcer and gastritis were identified, greatly exacerbated as compared with the endoscopic ... | 2011 | 21961102 |
| Detection of Helicobacter pylori DNA in a preliminary stage gastric cancer cells. | AIMS:: Helicobacter pylori (HP) DNA was assayed using a newly fabricated voltammetric handheld circuit equipped with an interfaced graphite pencil electrode (PE) sensor. METHODS:: Under optimum analytical parameters, the square-wave (SW) stripping detection range attained was 0.1-0.7?mg/L. RESULTS:: A relative standard deviation of 1.68% (RSD, n?=?5) was observed at a 3.2?mg/L HP DNA within a 90?s accumulation time. Under these conditions, the analytical detection limit approached 0.07?mg/L. CON ... | 2011 | 22186672 |
| Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. | A strong cellular cross-talk exists between the pathogen Helicobacter pylori and high-output NO production. However, how NO and H. pylori interact to signal in gastric epithelial cells and modulate the innate immune response is unknown. We show that chemical or cellular sources of NO induce the anti-inflammatory effector heme oxygenase-1 (HO-1) in gastric epithelial cells through a pathway that requires NF-?B. However, H. pylori decreases NO-induced NF-?B activation, thereby inhibiting HO-1 expr ... | 2011 | 21987660 |
| Stimulation of dendritic cells with Helicobacter pylori vacuolating cytotoxin negatively regulates their maturation via the restoration of E2F1. | Helicobacter pylori induces an infiltration of dendritic cells (DCs) into the infected gastric mucosa. Although DCs play an important role in the regulation of inflammation, the effects of H. pylori vacuolating cytotoxin (VacA) on DC maturation process have not yet been elucidated. The role of VacA in DC maturation following co-exposure to Escherichia coli lipopolysaccharide (LPS) was investigated. The treatment of immature DCs with LPS up-regulated the expression of surface molecules [e.g. CD40 ... | 2011 | 21910723 |
| Helicobacter pylori: beneficial for most? | | 2011 | 22017690 |
| [Genotyping and molecular marking of bacteria and viruses in epidemiological surveillance of actual infections]. | Determination of genetic and molecular features of pathogens circulating in Russia, in the northwest of the country and in St. Petersburg to resolve the problems of spread of diseases caused by these pathogens. | 2011 | 21913388 |
| Oral immunization with recombinant Mycobacterium smegmatis expressing the outer membrane protein 26-kilodalton antigen confers prophylactic protection against Helicobacter pylori infection. | Helicobacter pylori infection is prevalent worldwide and results in chronic gastritis, which may lead to gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer. We have previously reported that oral immunization with recombinant Mycobacterium smegmatis expressing the H. pylori outer membrane protein 26-kilodalton (Omp26) antigen affords therapeutic protection against H. pylori infection in mice. In the present study, we investigated the prophylactic effects of this vaccine candida ... | 2011 | 21900527 |
| antimicrobial activity of an amazon medicinal plant (chancapiedra) (phyllanthus niruri l.) against helicobacter pylori and lactic acid bacteria. | the potential of water extracts of the amazon medicinal plant chancapiedra (phyllanthus niruri l.) from ecuador and peru for antimicrobial activity against helicobacter pylori and different strains of lactic acid bacteria such as lactobacillus acidophilus, lactobacillus casei and lactobacillus plantarum was investigated. h. pylori was inhibited by both water extracts in a dose dependent manner, whereas lactic acid bacterial growth was not affected. both extracts contained ellagic acid and hydrox ... | 2011 | 22034238 |
| Ten-day sequential therapy is more effective than proton-pump inhibitor-based therapy in Korea: a prospective randomized study. | Background and Aims: The eradication rate of proton-pump inhibitor (PPI)-based triple therapy for Helicobacter pylori (H. pylori) infection has decreased mainly due to increasing antibiotic resistance, especially against clarithromycin. It has been reported that a 10-day sequential strategy can produce good outcomes. The aim of this prospective study was to assess the efficacy of sequential therapy as the first-line treatment for eradication of H. pylori in Korea. Materials and Methods: A total ... | 2011 | 21916989 |
| helicobacter pylori infection in patients with epilepsy. | the possible role of helicobacter pylori (hp) infection in extra-intestinal diseases has been suggested. the main purpose of this study was to determine the frequency of infection with hp in two groups of patients with epilepsy: patients with idiopathic generalized epilepsy (ige) and patients with temporal lobe epilepsy (tle), compared to healthy controls. | 2012 | 21903421 |
| Genotypic and phenotypic variation of Lewis antigen expression in geographically diverse Helicobacter pylori isolates. | Helicobacter pylori are a persistent colonizer of the human gastric mucosa, which can lead to the development of peptic ulcer disease and gastric adenocarcinomas. However, H. pylori can asymptomatically colonize a host for years. One factor that has been hypothesized to contribute to such persistence is the production of Lewis (Le) antigens in the lipopolysaccharide layer of the bacterial outer membrane as a form of molecular mimicry, because humans also express these antigens on their gastric m ... | 2011 | 22059399 |
| Pathobionts of the gastrointestinal microbiota and inflammatory disease. | Our immune system is charged with the vital mission of identifying invading pathogens and mounting proper inflammatory responses. During the process of clearing infections, the immune system often causes considerable tissue damage. Conversely, if the target of immunity is a member of the resident microbiota, uncontrolled inflammation may lead to host pathology in the absence of infectious agents. Recent evidence suggests that several inflammatory disorders may be caused by specific bacterial spe ... | 2011 | 21856139 |
| A randomized study comparing levofloxacin, omeprazole, nitazoxanide, and doxycycline versus triple therapy for the eradication of Helicobacter pylori. | Resistance to standard Helicobacter pylori (HP) treatment regimens has led to unsatisfactory cure rates in HP-infected patients. This study was designed to evaluate a novel four-drug regimen (three antibiotics and a proton pump inhibitor (PPI)) for eradication of HP infection in treatment-naive patients. | 2011 | 21989146 |
| [helicobacter pylori: an infection with local complications and systemic effects]. | | 2011 | 21882136 |
| [Helicobacter pylori--a friend in need]. | | 2011 | 22165187 |
| [comparison of various diagnostic methods of helicobacter infection]. | there has been conducted comparison of the most wide-spread methods of diagnosis of helicobacter pylori infection: histologic, cytologic, method of polymerase chain reaction (pmcr) and respiratory urease xelic-test on the method of ama firm. | 2011 | 21916228 |
| secular trends in helicobacter pylori seroprevalence in adults in the united states: evidence for sustained race/ethnic disparities. | helicobacter pylori seroprevalence levels in us adults participating in the continuous national health and nutrition examination survey (1999-2000) increased with age in all racial/ethnic groups, with significantly higher age-standardized levels in mexican americans (64.0%, 95% confidence interval (ci): 58.8, 69.2) and non-hispanic blacks (52.0%, 95% ci: 48.3, 55.7) compared with non-hispanic whites (21.2%, 95% ci: 19.1, 23.2). although seroprevalence levels remained similar to those found in na ... | 2012 | 22085628 |
| upper gi bleeding requires prompt investigation. | upper gi bleeding is a common medical emergency with an incidence in the uk of 103 cases per 100,000 adults per year and is much more common in the elderly. the most common presenting signs are haematemesis (bright red or 'coffee ground') and melaena. about 30% of patients with bleeding ulcers present with haematemesis, 20% with melaena, and 50% with both. up to 5% of patients with bleeding ulcers have haematochezia and this indicates heavy bleeding into the upper gi tract. an upper gi bleeding ... | 2011 | 21932501 |
| on the association between soft drink consumption and helicobacter pylori infection. | background: the association between soft drink (sd) consumption and helicobacter pylori infection remains unclear. aim: to examine the relationship between sd consumption and h. pylori infection. methods: a prospective study included individuals who were referred for an upper gastrointestinal endoscopic examination because chronic dyspepsia within a pe ... | 2011 | 22057241 |
| bacterial load and degree of gastric mucosal inflammation in helicobacter pylori infection. | helicobacter pylori induces an inflammatory immune response in the gastric mucosa. the degree of gastric mucosal inflammation and its topographic distribution are key factors in the diversity of h. pylori-related complications. here we summarize substantial evidence reported in the literature concerning the impact of h. pylori density on gastric inflammation, the development of severe complications, and its relation to h. pylori suppression therapy. most studies demonstrate a significant correla ... | 2011 | 22179216 |
| a case of monoclonal lymphoplasmacytosis of the bone marrow with igm-positive russell bodies. | a 71-year-old japanese male patient infected with hcv was diagnosed with thrombocytopenia. histological examination of the bone marrow aspirate showed numerous lymphoid aggregates with russell bodies. immunohistochemistry and flow cytometric analysis demonstrated clonal expansion of cd5+ cd23+ b cells. russell bodies were positive for igm and lambda immunoglobulin light chain. the patient also underwent gastric biopsy, which revealed helicobacter pylori (hp) infection. subsequent eradication of ... | 2011 | 22046570 |
| recent advances in the study of the helicobacter pylori caga oncoprotein. | | 2011 | 21891989 |
| metallo-gtpase hypb from helicobacter pylori and its interaction with nickel chaperone protein hypa. | the maturation of [nife]-hydrogenase is highly dependent on a battery of chaperone proteins. among these, hypa and hypb were proposed to exert nickel delivery functions during the metallocenter assembly, although the detailed mechanism remains unclear. herein, we have over-expressed and purified wild-type hypb as well as two mutants k168a and m186l/ f190v from helicobacter pylori. we demonstrated that all proteins bind ni2+ at a stoichiometry of one ni2+ per monomer of the proteins with dissocia ... | 2011 | 22179820 |
| helicobacter pylori infection as a risk factor for both primary open-angle glaucoma and pseudoexfoliative glaucoma in thessaloniki eye study. | | 2011 | 22107938 |
| comparison between invasive and noninvasive tests in diagnosis of helicobacter pylori infection. | in this study, the invasive and noninvasive diagnotic tests were compared to choose the appropriate test for diagnostice of h. pylori infection. helicobacter pylori (h. pylori) is a human pathogen that causes chronic gastritis, has a role in gastric and duodenal ulcer, is involved in gastric carcinogenesis and is regarded as a possible important factor in at least a subset of patients with functional dyspepsia. the diagnosis of h. pylori is an essential element in the management of many common g ... | 2010 | 21848076 |
| The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: linking gastric and Alzheimer's diseases together? | Helicobacter pylori causes such gastric diseases as gastritis, peptic ulcerations, gastric cancer and MALT lymphoma. Hpn is a histidine-rich protein abundant in this bacterium and forms amyloid-like oligomers in physiologically relevant conditions. Here we proposed the in vivo functions of this protein with relevance to its physical locations. The collective evidence presented here shed some light on the pathologic mechanisms of H. pylori infections, with emphasis on the bacterial colonization i ... | 2011 | 21852052 |
| Correlation between plasma or mucosal ghrelin levels and chronic gastritis. | The aim of this study was to clarify the relationship between plasma or mucosal ghrelin levels and endoscopic or histological severity, acid secretion and H. pylori infection associated with chronic gastritis. | 2011 | 21940353 |
| "Targeted disruption of the epithelial-barrier by Helicobacter pylori". | ABSTRACT: Helicobacter pylori colonizes the human gastric epithelium and induces chronic gastritis, which can lead to gastric cancer. Through cell-cell contacts the gastric epithelium forms a barrier to protect underlying tissue from pathogenic bacteria; however, H. pylori have evolved numerous strategies to perturb the integrity of the gastric barrier. In this review, we summarize recent research into the mechanisms through which H. pylori disrupts intercellular junctions and disrupts the gastr ... | 2011 | 22044698 |
| Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein CagL to integrins a(V)ß (3) and a (5)ß (1). | The human pathogen Helicobacter pylori that may cause different gastric diseases exploits integrins for infection of gastric cells. The H. pylori protein CagL present on the outer region of the type IV secretion pilus contains an RGD sequence (-Arg-Gly-Asp-) that enables binding to cells presenting integrins a(5)ß(1) and a(V)ß(3). This interaction can be inhibited with conformationally designed cyclic RGD peptides derived from the CagL epitope -Ala-Leu-Arg-Gly-Asp-Leu-Ala-. The inhibition of the ... | 2011 | 21915696 |
| spatial autocorrelation calculations of the nine malignant neoplasms in taiwan in 2005-2009: a gender comparison study. | spatial analytical techniques and models are often used in epidemiology to identify spatial anomalies (hotspots) in disease regions. these analytical approaches can be used to identify not only the location of such hotspots, but also their spatial patterns. we used spatial autocorrelation methodologies, including global moran's i and local getis-ord statistics, to describe and map spatial clusters and areas in which nine malignant neoplasms are situated in taiwan. in addition, we used a logistic ... | 2011 | 22035856 |
| JGHF Marshall & Warren Lecture: Anti-platelet therapy and managing ulcer risk. | Low-dose aspirin (ASA) has emerged as one of the most important causes of peptic ulcer bleeding in developed countries. Among the risk factors of ASA-associated ulcer bleeding, Helicobacter pylori infection is one of the few that is treatable. Recent evidence showed that among patients with a history of ASA-associated ulcer bleeding, the long-term incidence of recurrent bleeding with ASA use is low after eradication of H. pylori alone. Thus, test-and-treat H. pylori is a potentially useful strat ... | 2011 | 22142030 |
| byrsonima intermedia a. juss.: gastric and duodenal anti-ulcer, antimicrobial and antidiarrheal effects in experimental rodent models. | ethnopharmacological relevance: an ethnopharmacological survey indicated that the leaves of byrsonima intermedia a. juss. (malpighiaceae), a medicinal species commonly found in the brazilian cerrado, can be used against gastroduodenal disorders, such as gastric ulcers and diarrhea. aim of the study: the objective of this study was to evaluate the effects of a methanolic extract of byrsonima intermedia (mbi) leaves on gastric and duodenal ulcers and to assess the antimicrobial and antidiarrheal e ... | 2012 | 22265748 |
| helicobacter pylori eradication improves gastric atrophy and intestinal metaplasia in long-term observation. | background and aim:helicobacter pylori has been shown to cause atrophic gastritis and intestinal metaplasia (im), both of which are precancerous lesions. to clarify the mechanism by which h. pylori eradication prevents gastric cancer, we monitored atrophy and im improvement in gastric mucosa over a long period after h. pylori eradication. methods: we monitored 118 patients (72 males, 46 females; mean age 61.3 ± 5.1 years) for a mean of 8.6 years (range 5-13) after successful h. pylori eradicatio ... | 2012 | 22269293 |
| feca1, a bacterial iron transporter, determines the survival of helicobacter pylori in the stomach. | helicobacter pylori encodes a single iron-cofactored superoxide dismutase (sodb), which is regulated by the ferric uptake regulator (fur). ferrous ion (fe(2+)) is necessary for the activation of sodb. the activity of sodb is an important determinant of the capability of h. pylori for long-term colonization of the stomach and of the development of metronidazole (mtz) resistance of the bacterium. this study was conducted to characterize the fe(2+)-supply mechanisms for the activation of sodb in h. ... | 2011 | 22245091 |
| synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit helicobacter pylori-induced pathogenesis in human gastric epithelial cells. | helicobacter pylori infection is associated with gastritis, peptic ulcer, and even gastric malignancy. h. pylori's antibiotic resistance is the major obstacle preventing its eradication. a series of 3,4,5-trimethoxybenzylbenzimidazole derivatives were synthesized and evaluated for their anti-h. pylori activity. the compound, 2-fluorophenyl-5-methyl-1-(3,4,5-trimethoxybenzyl)benzimidazole (fmtmb), was determined as the most potent in the inhibition of h. pylori growth and pathogenesis of host cel ... | 2012 | 22217866 |
| influence of proton pump inhibitor treatment on helicobacter pylori stool antigen test. | to investigate the effects of proton pump inhibitor (ppi) treatment on stool antigen test using the testmate pylori enzyme immunoassay. | 2012 | 22228969 |
| immune modulation by regulatory t cells in helicobacter pylori-associated diseases. | regulatory t cells (treg) have the ability to suppress the activity of most other lymphoid cells as well as dendritic cells through cell-cell contact dependent mechanisms, which have not yet been fully defined. treg are a key component of a functional immune system, and treg deficiency is associated with severe autoimmunity and allergies. antigen-specific treg accumulate in gastric tissue during both helicobacter pylori-induced gastritis and peptic ulcer disease (pud). several studies suggest th ... | 2012 | 22214337 |
| is elevated gastric tissue nox2 associated with lymphoma of mucosa-associated lymphoid tissue? | helicobacter pylori infection plays a crucial role in the pathogenesis of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (malt). however, the host response to this infection is also important in the development of the disease. in particular, nadph oxidases (nox) which generate reactive oxygen species (ros) are known to induce cell damage possibly leading to carcinogenesis. we analyze for the first time nox expression in a series of well characterized gastric malt ... | 2012 | 22229863 |
| usefulness of magnifying narrow-band imaging endoscopy for the diagnosis of gastric and colorectal lesions. | a series of studies about the potential usefulness of magnifying endoscopy with narrow-band imaging (nbi) for the diagnosis of gastric and colonic lesion is reviewed. concerning the magnifying nbi appearances of gastric lesions, a light blue crest is a highly accurate sign of the presence of histological intestinal metaplasia. also, the degree of irregularity of the mucosal and vascular pattern is correlated with the histological severity of helicobacter pylori-associated chronic gastritis. acco ... | 2012 | 22269282 |
| helicobacter pylori caga diversity associated with the difference of gastric mucosal injury. | | 2012 | 22222245 |
| foxp3+ regulatory t cells in children with helicobacter pylori infection. | abstract despite an intensive pro-inflammatory response, the immune system is unable to clear the organism in helicobacter pylori (h. pylori) gastritis. regulatory t (treg) cells which suppress the immune response of antigen-specific t cells has recently been demonstrated to be a key role for chronic inflammation by immunologic tolerance. the purpose of our study is to investigate the histopathology, foxp3+treg cell expression and immune responses in children with h. pylori infection. twenty-f ... | 2012 | 22260624 |
| unusual nadph conformation in the crystal structure of a cinnamyl alcohol dehydrogenase from helicobacter pylori in complex with nadp(h) and substrate docking analysis. | cinnamyl alcohol dehydrogenase is a zinc- and nadph-dependent dehydrogenase catalyzing the reversible conversion of p-hydroxycinnamaldehydes to their corresponding hydroxycinnamyl alcohols. a cad homolog from helicobacter pylori (hpcad) possesses broad substrate specificities like the plant cads and additionally a dismutation activity converting benzaldehyde to benzyl alcohol and benzoic acid. we have determined the crystal structure of hpcad complexed with nadp(h) at 2.18å resolution to get a b ... | 2012 | 22269576 |
| [prevalence of helicobacter pylori infection in anemia by vitamin b12 deficiency in marrakech (morocco).] | | 2012 | 22244727 |
| the endoscopic course of scattered white spots in the descending duodenum: a prospective study. | aim: scattered white spots (swss) in the descending duodenum are an uncommon finding of upper gastrointestinal system endoscopy (ugse). intestinal lymphangiectasia, chronic nonspecific duodenitis and giardiasis are associated with a sws appearance. the aim of this study was to determine the frequency of sws during routine endoscopy, as well as to evaluate the effect of treatment on this finding. materials and methods: patients undergoing ugse with a sws appearance in the descending duodenum were ... | 2012 | 22260755 |
| a potential of some medicinal plants as an antiulcer agents. | peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. the formation of peptic ulcers depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. there are two major factors that can disrupt the mucosal resistance to injury: non-steroidal antiinflammatory drugs (nsaids) example, aspirin and helicobacter pylori infection. numerous natural products have been evaluated as therapeutics for the treatment of ... | 2010 | 22228953 |
| helicobacter pylori infection and primary open-angle glaucoma: is there a connection? | glaucoma, the most common form of which is primary open-angle glaucoma (poag), is a neurodegenerative disease which is the second most common cause of blindness worldwide. among the factors that have been implicated in the pathophysiology of this disease is infection with helicobacter pylori. this alleged association has caused a great deal of scientific discussion during the past decade, as the establishment of such a correlation might lead to therapeutic applications for all glaucoma patients. ... | 2012 | 22259235 |
| the kinase activity of the helicobacter pylori asp-trna(asn)/glu-trna(gln) amidotransferase is sensitive to distal mutations in its putative ammonia tunnel. | the helicobacter pylori (hp) asp-trna(asn)/glu-trna(gln) amidotransferase (adt) plays important roles in indirect aminoacylation and translational fidelity. adt has two active sites, in two separate subunits. kinetic studies have suggested that interdomain communication occurs between these subunits; however, this mechanism is not well understood. to explore domain-domain communication in adt, we adapted an assay and optimized it to kinetically characterize the kinase activity of hp adt. this as ... | 2012 | 22229412 |
| variations in helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: implications for prevention. | helicobacter pylori (hp) is a bacterium that colonizes the human stomach and can establish a long-term infection of the gastric mucosa. persistent hp infection often induces gastritis and is associated with the development of peptic ulcer disease, atrophic gastritis, and gastric adenocarcinoma. virulent hp isolates harbor the cag (cytotoxin-associated genes) pathogenicity island (cagpai), a 40 kb stretch of dna that encodes components of a type iv secretion system (t4ss). this t4ss forms a pilus ... | 2012 | 22235308 |
| helicobacter pylori serologic status has no influence on the association between fucosyltransferase 2 polymorphism (fut2 461 g->a) and vitamin b-12 in europe and west africa. | genomewide association studies have shown a relation between plasma vitamin b-12 concentration and the 461g→a polymorphism of fucosyltransferase 2 (fut2), a gene associated with susceptibility to helicobacter pylori infection. | 2012 | 22237057 |
| helicobacter pylori serum antibody titers in patients with cerebral non-cardioembolic ischemic stroke. | helicobacter pylori (h. pylori) infection has been associated with atherosclerosis of coronary arteries but there is lack of data regarding possible association between chronic h. pylori infection and cerebral non-cardioembolic ischemia. we evaluated h. pylori serum antibody titers in patients with cerebral non-cardioembolic ischemic stroke. | 2011 | 22247726 |
| structural and biochemical characterization of hp0315 from helicobacter pylori as a vapd protein with an endoribonuclease activity. | vapd-like virulence-associated proteins have been found in many organisms, but little is known about this protein family including the 3d structure of these proteins. recently, a relationship between the cas2 family of ribonucleases associated with the crispr system of microbial immunity and vapd was suggested. here, we show for the first time the structure of a member of the vapd family and present a relationship of vapd with cas2 family and toxin-antitoxin (ta) systems. the crystal structure o ... | 2012 | 22241770 |
| stimulation of th1 response by helicobacter pylori neutrophil activating protein decreases the protective role of ige and eosinophils in experimental trichinellosis. | th2 responses seem to play an important role in defence against trichinella spiralis (ts). the neutrophil activating protein of helicobacter pylori (hp-nap), that induces il-12, and il-23 expression and shifts to th1 allergen-specific th2 cells in vitro was used as an anti-th2 agent in balb/c mice infected with t. spiralis. the muscle larvae (ml) burden was lower (p < 0.02) in untreated infected animals than those infected treated with hp-nap. in both groups there was an inverse relations ... | 2011 | 22230396 |
| detection of helicobacter pylori and caga gene in nasal polyps and benign laryngeal diseases. | background and aims: helicobacter pylori is the most common etiological factor of chronic infection worldwide. it has also been found in human dental plaques, mouth, saliva, tonsils and adenoid tissue, medial ear or nasal polyps and sinuses mucosa, as well in several benign and malignant lesions of the larynx and pharynx. the aim of the study was to investigate the association of h. pylori colonization in chronic rhinosinusitis and benign laryngeal diseases. methods: the prospective, controlled ... | 2012 | 22222490 |
| helicobacter pylori vaca intermediate region genotyping and progression of gastric preneoplastic lesions. | | 2012 | 22218041 |
| helicobacter pylori caga inhibits the expression of runx3 via src/mek/erk and p38 mapk pathways in gastric epithelial cell. | infection with caga-positive helicobacter pylori is the strongest risk factor for gastric carcinoma. upon delivery into gastric epithelial cells, caga disturbs cellular functions by physically interacting with and deregulating intracellular signaling molecules via both tyrosine phosphorylation-dependent and -independent mechanisms. runx3 was suggested to be a tumor suppressor and closely associated with tumorigenesis and progression of gastric cancer. the aim of our study is to verify the effect ... | 2012 | 22266963 |
| clinical findings and prevalence of helicobacter pylori in patients with gastritis b in al-basrah governorate. | to detect the prevalence of h. pylori in patients with gastritis b. | 2009 | 22224187 |
| furazolidone in helicobacter pylori therapy: misunderstood and often unfairly maligned drug told in a story of french bread. | | 2012 | 22249084 |
| micronutrients (other than iron) and helicobacter pylori infection: a systematic review. | background: many micronutrients depend on a healthy stomach for absorption. helicobacter pylori chronic gastritis may alter gastric physiology affecting homeostasis of vitamins and minerals. objectives: systematic review to assess whether h. pylori infection is associated with reduced micronutrient levels (other than iron) in the plasma or gastric juice and whether low micronutrient levels are modified by eradication treatment. method: medline was searched for relevant publications from incep ... | 2012 | 22221610 |
| necrotizing periodontal diseases in hiv-infected brazilian patients: a clinical and microbiologic descriptive study. | objective: nowadays, necrotizing periodontal diseases have a low prevalence; however, a better understanding of the etiopathogenesis of these diseases is necessary for determining more adequate preventive and therapeutic strategies. method and materials: from a pool of 1,232 hiv-infected patients, 15 presented with necrotizing periodontal diseases, which were evaluated by full-mouth periodontal clinical measurements. subgingival biofilm samples were collected from necrotizing lesions of six of t ... | 2012 | 22259811 |
| rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers. | abstract background and aims. atrophic gastritis (ag) results most often from helicobacter pylori (h. pylori) infection. ag is the most important single risk condition for gastric cancer that often leads to an acid-free or hypochlorhydric stomach. in the present paper, we suggest a rationale for noninvasive screening of ag with stomach-specific biomarkers. methods. the paper summarizes a set of data on application of the biomarkers and describes how the test results could be interpreted i ... | 2012 | 22242613 |
| prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae. | aberrant dna methylation is frequently found during gastric carcinogenesis. recently, we identified potential methylation markers important for helicobacter pylori-induced gastric carcinogenesis using an illumina methylation chip assay. in this study, we evaluated the candidate genes as markers for gastric cancer (gc) in a large korean population. dna methylation of ptpn6, mos, dcc, crk, and vav1 was evaluated in non-neoplastic gastric specimens using quantitative methylation-specific pcr in pat ... | 2011 | 22252584 |
| natural history of helicobacter pylori infection in childhood: eight-year follow-up cohort study in an urban community in northeast of brazil. | background: helicobacter pylori infection is acquired predominantly in childhood. there is also evidence that children loss the infection. therefore, factors that account for children remain infected need to be investigated because once established the infection persists throughout the life unless treated. methods: this study aimed to evaluate the h. pylori infection in children of a low-income community at baseline and 8 years later to determine the predictor factors linked to the maintenance ... | 2012 | 22221612 |
| trends in peptic ulcer disease and the identification of helicobacter pylori as a causative organism: population-based estimates from the us nationwide inpatient sample. | peptic ulcer disease can lead to serious complications including massive hemorrhage or bowel perforation. the modern treatment of peptic ulcer disease has transitioned from the control of gastric acid secretion to include antibiotic therapy in light of the identification of helicobacter pylori as a causative infectious organism. we sought to determine trends related to this discovery by using a national database. | 2011 | 22224001 |
| strain-specific colitis susceptibility in il10-deficient mice depends on complex gut microbiota-host interactions. | background: colitis susceptibility in il10(-/-) mice depends on genetic background and microbiota composition. a major genetic locus mediating colitis susceptibility, cdcs1, was transferred from susceptible c3bir-il10(-/-) to resistant b6-il10(-/-) mice, resulting in susceptible congenic bc-r3-il10(-/-) mice. the aim of this study was to determine the impact of microbiota on this differential colitis susceptibility using a helicobacter hepaticus infection model. methods: parental c3bir-il10( ... | 2012 | 22238116 |
| prognostic value of helicobacter pylori sinonasal colonization for efficacy of endoscopic sinus surgery. | compared with rhinologic patients without chronic rhinosinusitis (crs), a higher prevalence of sinonasal helicobacter pylori (hp) in patients with crs was found. this study investigated if hp sinonasal colonization has a prognostic value for efficacy of functional endoscopic sinus surgery (fess). nasal polyps of 40 patients with crs, undergoing fess, were analyzed for presence of hp using immunohistochemistry (ihc). patients were categorized as to whether the ihc was positive (hp+ group) or nega ... | 2012 | 22237763 |
| inverse association between helicobacter pylori and pediatric asthma in a high-prevalence population. | background: helicobacter pylori-associated disease has led to aggressive diagnostic and eradication protocols that are partially responsible for the decrease in prevalence of h. pylori carriage. recent evidence indicates that in low-prevalence populations, h. pylori may have protective effects on allergic diseases. the aim of this study was to explore the relationship between pediatric asthma and h. pylori infection in a population with high prevalence of h. pylori infection. materials and meth ... | 2012 | 22221613 |