| surgery of pancreatic cancer in the new millennium: better prediction of outcome. | background:: surgery is the only therapy with potentially curative intention in pancreatic cancer. this analysis aimed to determine prognostic parameters in a patient cohort with resected pancreatic adenocarcinoma with a special focus on the revised r1-definition. methods:: between october 2001 and august 2009, data from 1071 consecutively resected patients with pancreatic adenocarcinoma were prospectively collected in an electronical database. parameters tested for survival prediction in univar ... | 2011 | 21606835 |
| factors influencing bone loss in paraplegia. | background and aim: significant bone loss develops in the first months and continues years after spinal cord injury. a cross - sectional comparative study was performed to evaluate factors influencing bone loss in spinal cord injured men with paraplegia.patients and methods: we studied 31 paraplegic men in chronic stage (>1.5 years) in comparison with 30 able-bodied men of similar age, height, and weight. the paraplegic men were allocated into 2 subgroups based on the neurological level of injur ... | 2011 | 21607037 |
| the role of tumor size and patient's age as prognostic factors in laryngeal cancer. | background and aim: the loco-regional recurrence of laryngeal carcinoma in patients who underwent total laryngectomy is related to numerous factors. aim of the present study was to investigate the role of patient's age and tumor size in the recurrence rate of patients. additional aim of the current study was to investigate the possible associations between the size of the tumor and other characteristics.patients and methods: in 1st department of otorhinolaryngology of ahepa university hospital, ... | 2011 | 21607041 |
| spect/ct imaging in children with papillary thyroid carcinoma. | background: spect/ct improves localization of single photon-emitting radiopharmaceuticals. objective: to determine the utility of spect/ct in children with papillary thyroid carcinoma. materials and methods: 20 spect/ct and planar studies were reviewed in 13 children with papillary thyroid carcinoma after total thyroidectomy. seven studies used i-123 and 13 used i-131, after elevating tsh by t4 deprivation or intramuscular thyrotropin alfa. eight children had one study and five children had two ... | 2011 | 21607603 |
| [effects of different film mulch and ridge-furrow cropping patterns on yield formation and water translocation of rainfed potato]. | this paper studied the effects of different film mulch and ridge-furrow cropping patterns on the yield formation and water translocation of rainfed potato in the semi-arid area of west loess plateau. comparing with those under traditional harrowed bedding without film mulch (t1), the potato yield under harrowed bedding with film mulching (t2), completely mulched alternating narrow and wide ridges with furrow planting (t3), completely mulched alternating narrow and wide ridges with ridge planting ... | 2011 | 21608252 |
| [a retrospective analysis of clinicopathological characteristics and prognostic factors of gastric stump cancer]. | to explore the clinicopathological characteristics and prognostic factors of gastric stump cancer(gsc). | 2011 | 21609561 |
| an interaction between the walker a and d-loop motifs is critical to atp hydrolysis and cooperativity in bacteriophage t4 rad50. | the atp binding cassette (abc) proteins make up a large superfamily with members coming from all kingdoms. the functional form of the abc protein nucleotide binding domain (nbd) is dimeric with atp binding sites shared between subunits. the nbd is defined by six motifs: the walker a, q-loop, signature, walker-b, d-loop, and h-loop. the d-loop contains a conserved aspartate whose function is not clear but has been proposed to be involved in cross-talk between atp binding sites. structures of vari ... | 2011 | 21610075 |
| a facile method for the assessment of dna damage induced by uv-activated nanomaterials. | fluorescent microscopy observation of gene-size dna (t4 phage dna or λ phage dna) was used to assess dna damage induced by uv irradiation in the presence of nanomaterials, such as qds (quantum dots: cdse/zns semiconductor nanoparticles), the water-soluble fullerene derivative c(60)(oh)(n) (n = 6-12) and titanium oxide nanoparticles of 25 nm in diameter. the magnitude of dna damage could be simply evaluated based on the degree of shortening of the stretched dna image. this method showed that dna ... | 2011 | 21614347 |
| the complete genome sequence of a novel t4-like bacteriophage, ime08. | | 2011 | 21614434 |
| expression analysis of prestin and selected transcription factors in newborn rats. | transcription factors (tfs) have a central role to play in regulating gene expression. to analyze the co-expression patterns of selected tfs with the motor protein prestin of the outer hair cells, we applied an real-time pcr approach combining several kinds of information: (i) expression changes during postnatal development, (ii) expression changes by exposure of organotypic cultures of the organ of corti to factors which significantly affect prestin expression [thyroid hormone (t4), retinoic ac ... | 2011 | 21614551 |
| adenocarcinoma of the ethmoid sinus: retrospective study of 42 cases. | objectives: retrospective analysis of the oncological results and morbidity of ethmoid sinus adenocarcinoma surgery, and identification of survival factors. material and methods: forty-two patients were treated from 1990 to 2009. the study covered clinical presentation, medical imaging, histologic data, tnm grade, treatment, morbidity and overall recurrence-free survival. results: forty-one men and one woman, with mean age at diagnosis of 61.5 years, were included. 85.7% had been exposed to wood ... | 2011 | 21616740 |
| [the role of chemotherapy in the management of bladder cancer.] | bladder cancer represents for man the second genitourinary cancer after prostate cancer. urothelial carcinoma is the most predominant histological type. in up to 70% of the cases, the diagnosis of bladder cancer is performed at early stages (ta-t1). in this situation, the treatment of the disease is the transurethral resection with or without intravesical treatment (bcg, amiticyne). in advanced disease, treatment is essentially palliative with chemotherapy based on cisplatin type mvac (methotrex ... | 2011 | 21620296 |
| neoadjuvant chemoradiation for clinically advanced non-small cell lung cancer: an analysis of 233 patients. | background: surgical intervention after chemoradiation for locoregionally advanced non-small cell lung cancer (nsclc) is controversial. this study evaluated patient survival after neoadjuvant chemoradiation and anatomic pulmonary resections for locoregionally advanced nsclc. methods: clinicopathologic data were retrospectively collected for 233 patients (110 women, 123 men) with nsclc who underwent chemoradiation therapy, followed by pneumonectomy, sleeve lobectomy, bilobectomy, and standard lob ... | 2011 | 21620372 |
| the role of laparoscopic and robotic cystectomy in the management of muscle-invasive bladder cancer with special emphasis on cancer control and complications. | context: minimally invasive radical cystectomy (mirc) techniques for the treatment of muscle-invasive bladder cancer (bca) are being increasingly applied. mirc offers the potential benefits of a minimally invasive approach in terms of reduced blood loss and analgesic requirements whilst striving to provide similar oncologic efficacy to open radical cystectomy (orc). whether quicker recovery, shorter hospital stay, and a reduction in complications are routinely achieved with mirc remains to be pr ... | 2011 | 21620562 |
| proposal of new nodal classifications for non-small-cell lung cancer based on the number and ratio of metastatic lymph nodes. | objective: the study aimed to evaluate the effectiveness of two new nodal classifications based on the number of metastatic lymph nodes (lns) or ratio of metastatic to examined lns (lnr) in making a prognosis, compared with the current nodal classification based on the location of metastatic lns. methods: we analyzed 651 non-small-cell lung cancer patients who had undergone complete resection with the removal of more than five lns between 1986 and 2003, excluding preoperative treatment cases, an ... | 2011 | 21620720 |
| changes in life style improve body composition, thyroid function and structure in obese children. | background. alterations in thyroid function and structure have been reported in obesity. function reverses to normal after weight loss, but nothing is known about structure. aim. to evaluate the effect of weight loss on thyroid function and structure in obese children. subjects and methods: the study was conducted in 72 overweight and obese children. measurement of ft3, ft4, tsh, antithyroid-antibodies and a thyroid ultrasound was performed at the beginning (phase 1) and after a period of 1.8 ± ... | 2011 | 21623157 |
| long-term results of salvage photodynamic therapy for patients with local failure after chemoradiotherapy for esophageal squamous cell carcinoma. | background and study aims: local failure after chemoradiotherapy (crt) remains a major problem for patients with esophageal squamous cell carcinoma (escc). the aim of this study was to clarify the long-term results of salvage photodynamic therapy (pdt) for local failure. patients and methods: patients were treated with crt, consisting of more than 50 gy irradiation and concurrent chemotherapy. the indications for salvage pdt were as follows: 1) absence of lymph-node or distant metastasis after c ... | 2011 | 21623555 |
| genereviews | mct8 (slc16a2)-specific thyroid hormone cell transporter deficiency is characterized by severe cognitive deficiency, infantile hypotonia, diminished muscle mass and generalized muscle weakness, progressive spastic quadriplegia, joint contractures, and dystonic and/or athetoid movement with characteristic paroxysms or kinesigenic dyskinesias. seizures occur in about 25% of cases. most affected males never sit or walk independently or lose these abilities over time; most never speak or have severe ... | 1993 | 20301789 |
| screening for thyroid disease | this article focuses on whether it is useful to order a thyroid function test in
patients who have no history of thyroid disease and have few or no signs or
symptoms of thyroid dysfunction. | 2004 | 20722119 |
| morphological, haemato-biochemical and endocrine changes in young standardbreds with 'maladaptation' to early training. | the demands in the standardbred trotters industry require young, still growing horses, to be trained well above light exercise level. during that period, the risk of occurrence of energy imbalance and maladaptation to training is high. in man, the lack of energy homeostasis is considered as the basic problem in the development of chronic fatigue. | 2010 | 21059002 |
| advances in patient safety: new directions and alternative approaches (vol. 3: performance and tools) | objective: maintenance of competence in orotracheal intubation skills is challenging for non-anesthesiologists who do not practice intubation routinely. we hypothesized that discipline, recent training, and experience would affect immediate skill improvement during refresher training. methods: experienced pediatric providers refreshed intubation skills in six simulated infant trauma scenarios with cervical spine protection. time (t) to successful intubation (in seconds) was used to calculate ref ... | 2008 | 21249918 |
| clinical methods: the history, physical, and laboratory examinations | thyroid function tests are designed to distinguish hyperthyroidism and hypothyroidism from the euthyroid state. to accomplish this task, direct measurements of the serum concentration of the two thyroid hormones—triiodothyronine (t3) and tetraiodothyronine (t4)—more commonly known as thyroxine, are extensively employed. the t3 resin uptake (t3ru) is used as an indirect measure of serum thyroid hormone binding capacity, and the free t4 index (ft4i), derived from the t4 and t3ru, corrects estimate ... | 1990 | 21250093 |
| axillary lymph node metastases detection with nuclear medicine approaches in patients with newly diagnosed breast cancer. | three different tracers, tc-99m-sesta mibi, in-111-pentetreotide and f-18-fdg, were evaluated in a preliminary study in three different groups of 10 breast cancer patients programmed for breast cancer resection and axillary dissection. planar scintigraphy and single photon emission tomography (spet) technique were used for imaging with tc-99m-sesta-mibi and in-111-pentetreotide, positron emission tomography (pet) was used for imaging with f-18-fdg. we studied 30 breast cancer patients; their cli ... | 1996 | 21544415 |
| experimental hyperthyroidism enhances the regeneration of central neurites promoted by peripheral nerve grafts in the hippocampus. | the aim of the present paper was to ascertain whether experimental hyperthyroidism promotes the regenerative action of predegenerated peripheral nerve grafts implanted into the transected hippocampus. hyperthyroidism was induced by subcutaneous injections of t4. autologous peripheral nerve grafts were implanted immediately, 7 and 35 days following transection of the sciatic nerve. cells extending their neurites into the grafts were traced by means of horseradish peroxidase conjugated with fluore ... | 1993 | 21551731 |
| chromosome-11q13 gene amplifications in head and neck squamous-cell carcinomas - relation with lymph-node invasion. | gene amplifications occurring in the q13 band of chromosome 11 are frequently observed in head and neck squamous cell carcinomas. in order to determine the relative frequency of amplification in 5 distinct 11q13 loci and their relation with clinical data, tumor dnas from 31 patients - including 26 who had undergone neck dissection (lymph node histology available) - were evaluated by southern blot. specific probes were used for the d11s833e, fgf3, cycd1, d11s97 and gst-pi loci. the most frequentl ... | 1994 | 21559590 |
| chromosomal markers as prognostic indicators in transitional-cell carcinomas of the bladder. | clinical-cytogenetic correlations were assessed in 79 patients with transitional cell carcinomas of the bladder to whom cytogenetic analysis of the primary tumor had been successful. high-grade (g2+g3) and high-stage (t2-t4) tumors had in general a higher ploidy level and contained more marker chromosomes, including multiple markers, compared to low-grade (g0+g1) and low stage (ta+t1) tumors. the early recurrence rate (within 7 months) was significantly higher (p<0.05) in patients whose tumors c ... | 1993 | 21573351 |
| immunoassay for thymidylate synthase in cytosols from human colorectal-carcinoma cell-lines. | thymidylate synthase (ts) is an essential enzyme for dna biosynthesis that is an important target of fluoropyrimidine anti-cancer drugs such as 5-fluorouracil (5-fu), which is frequently used against human colon adenocarcinomas. because levels of ts in such tumors may be predictive of chemotherapeutic response to 5-fu, it is desirable to have a method for ts quantitation simpler than the laborious conventional biochemical assays that currently exist. we therefore describe a rapid and simple immu ... | 1993 | 21573550 |
| phenazine-naphthalene-1,5-diamine-water (1/1/2). | the asymmetric unit of the title compound, c(12)h(8)n(2)·c(10)h(10)n(2)·2h(2)o, contains one half-mol-ecule of phenazine, one half-mol-ecule of naphthalene-1,5-diamine and one water mol-ecule. the phenazine and naphthalene-1,5-diamine mol-ecules are located on inversion centers. the water mol-ecules serve as bridges between the naphthalene-1,5-diamine mol-ecules and also between the naphthalene-1,5-diamine and phenazine mol-ecules. the naphthalene-1,5-diamine and water mol-ecules are connected v ... | 2009 | 21578891 |
| preoperative radiotherapy for muscle-invading bladder-carcinoma. | one hundred five patients with clinical stage t2-t4 transitional cell bladder carcinoma who completed either low-dose (20-26 gy) or high dose (40-50 gy) preoperative radiotherapy (rt) followed by cystectomy were reviewed. five-year actuarial survival was 42%, 52%, and 17% for stages t2, t3, and t4, respectively. five-year local control rates for stages t2, t3, and t4 was 93%, 93% and 22%, respectively. survival, local control, distant metastasis and complications were similar for both preoperati ... | 1992 | 21584580 |
| vascular endothelial growth factor expression correlates with hematogenous metastasis and prognosis in colorectal carcinoma. | we investigated the expression of vascular endothelial growth factor (vegf) in 175 colorectal carcinomas by immunohistochemistry. vegf expression was correlated with advanced tnm stage (iii, iv), advanced t stage (t3, t4), vessel involvement, lymph node metastasis, and liver metastasis. with regard to the prognosis, both overall and relapse-free survival was significantly poorer, and furthermore, the hematogenous recurrences were significantly more commonly found in the patients with vegf-positi ... | 1997 | 21590063 |
| high urinary hydroxyproline excretion in patients with advanced head and neck cancer. | we studied the urinary excretion of hydroxyproline, measured as the hydroxyproline-to-creatinine ratio (hop/cr), in sixty-six patients with head and neck disease including, 18 patients with head and neck cancer. urinary hydroxyproline excretion was determined before treatment by the linear gradient elution method. although the urinary excretion of hydroxyproline is considered to be useful in monitoring cancer tissue such as prostate carcinomas, no studies have been performed on the urinary excre ... | 1997 | 21590105 |
| p53 gene alterations in differentiated thyroid cancers. | analysis of 22 human thyroid cancers including papillary, follicular and medullary subtypes (ptc, ftc, mtc) by pcr-sscp, and immunohistochemistry detected 4 deletions and 3 mutations. deletions involved exons 1, 2-3 and 5-6 in 3 ptcs, mutations exons 2-3 in 2 mtcs and exons 8-9 in ptc4. p53 alterations occurred in 2/5 recurrent tumors and 2/3 tumors developing to cell lines. immuno-histochemistry detected p53 mutations in differentiated areas of papillary thyroid cancers as frequent events occur ... | 1995 | 21597808 |
| epigenetic states and expression of imprinted genes in human embryonic stem cells. | to investigate the epigenetic states and expression of imprinted genes in five human embryonic stem cell (hesc) lines derived in taiwan. | 2010 | 21607126 |
| mast-cell frequency within tumor correlates to the stage of tongue cancer. | hydrolytic enzymes and angiogenic signals produced from mast cells have been suggested to be involved in the ability of tumours to invade normal tissues. in an approach to further test the hypothesis of the potential importance of mast cells in tumour growth we have compared the frequency of mast cells in tumour specimens from squamous cell carcinoma of the tongue stage t1 and t4. the results demonstrated a correlation of the frequency of mast cells within tumour with the stage of tongue cancer. ... | 1994 | 21607380 |
| the increased incidence of congenital hypothyroidism: fact or fancy? | objective: the incidence of congenital hypothyroidism (ch) detected by newborn screening in the us has increased significantly since the early 1990s. we defined the characteristics associated with the increased incidence. patients: a cohort of children with ch born during an earlier period of low incidence (1991-94) was compared with a cohort born during a later period when the incidence of ch had doubled (2001-04). measurements: screening was performed with t4 as the primary marker and tsh o ... | 2011 | 21623857 |
| neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher t3 transfer by milk after nicotine withdraw. | maternal nicotine exposure leads to neonatal hypothyroidism that can be returned to euthyroidism after nicotine withdrawal. here, we examined the transfer of iodine through milk, deiodinase activities (d1 and d2), and serum t3, t4 and tsh in rat offspring after maternal exposure to nicotine. one day after birth, a minipump was implanted to dams releasing nicotine (nic), 6mg/kg/day for 13days or vehicle saline. animals were killed at the day 15 and 21 of lactation. at day 15, nic-treated dams sho ... | 2011 | 21624425 |
| upregulation of mrna myocardium calcium handling in rats submitted to exercise and food restriction. | background: chronic exercise and food restriction (fr) have directionally opposite changes in transcription of molecular structures of calcium handling and thyroid hormone (th) status. objective: evaluate the association of chronic exercise and fr on serum thyroid hormones and gene transcription of molecular structures of intracellular calcium transients and thyroid receptors in myocardium of rats. methods: male wistar kyoto rats, divided into two groups: control (c, n = 7), fr (r50, n = 7), chr ... | 2011 | 21625820 |
| the hox gene network in hepatocellular carcinoma. | liver organogenesis and cancerogenesis share common mechanisms. hox genes control normal development, primary cellular processes and are characterized by a unique genomic network organization. less is known about the involvement of hox genes with liver cancerogenesis. the comparison of the hox gene network expression between nontumorous livers and hepatocellular carcinomas (hccs) highlights significant differences in the locus a hox genes, located on chromosome 7, with a consistent overexpressio ... | 2011 | 21626505 |
| purification of phage display-modified bacteriophage t4 by affinity chromatography. | abstract: background: affinity chromatography is one of the most efficient protein purification strategies. this technique comprises a one-step procedure with a purification level in the order of several thousand-fold, adaptable for various proteins, differentiated in their size, shape, charge, and other properties. the aim of this work was to verify the possibility of applying affinity chromatography in bacteriophage purification, with the perspective of therapeutic purposes. t4 is a large, ico ... | 2011 | 21627821 |
| beta blockers and breast cancer mortality: a population-based study. | purpose preclinical studies have demonstrated that antagonism of β(2)-adrenergic signaling inhibits several pathways necessary for breast tumor progression and metastasis. a series of population-based observational studies were conducted to examine associations between beta blocker use and breast tumor characteristics at diagnosis or breast cancer-specific mortality. patients and methods linked national cancer registry and prescription dispensing data were used to identify women with a diagnosis ... | 2011 | 21632503 |
| structure of the three n-terminal immunoglobulin domains of the highly immunogenic outer capsid protein from a t4-like bacteriophage. | the head of bacteriophage t4 is decorated with 155 copies of the highly antigenic outer capsid protein or hoc. one hoc molecule binds near the center of each hexameric capsomer. hoc is dispensable for capsid assembly and has been used to display pathogenic antigens on the t4 surface. here we report the crystal structure of a protein containing the first three of four domains of hoc from the bacteriophage rb49, a close relative of t4. the structure shows an approximately linear arrangement of the ... | 2011 | 21632759 |
| levothyroxine absorption in morbidly obese patients before and after roux-en-y gastric bypass (rygb) surgery. | background: roux-en-y gastric bypass (rygb) modifies the anatomical structure of the upper intestine tract, reduces gastric acid secretion, and may impair lt4 absorption. the aim of this study was to evaluate the lt4 absorption in morbidly obese patients before and after rygb. methods: thirty morbidly obese patients were divided in two groups: the ns group included 15 patients before rygb surgery (bmi = 43.1 ± 4 kg/m(2)), and the s group included 15 patients after surgery (bmi = 37.3 ± 4 kg/m(2) ... | 2011 | 21633823 |
| sentinel node biopsy should be offered in thin melanoma with mitotic rate greater than one. | background the american joint committee on cancer recently added mitotic rate (mr) to their seventh edition staging system for melanomas, which went into effect on january 1, 2010. mr has replaced the clark level of invasion for t1 melanomas. dermatologists and dermatopathologists should be aware of these new guidelines. objective to clarify how mr may be used to determine the prognosis of thin melanomas and to identify patients with thin melanomas who would be candidates for a sentinel lymph no ... | 2011 | 21635622 |
| alternative promoter usage and differential expression of multiple transcripts of mouse prkar1a gene. | prkar1a gene encodes regulatory type 1 alpha subunit (riα) of camp-dependent protein kinase (pka) in mouse. the role of this gene has been implicated in carney complex and many cancer types that suggest its involvement in physiological processes like cell cycle regulation, growth and/or proliferation. we have identified and sequenced partial cdna clones encoding four alternatively spliced transcripts of mouse prkar1a gene. these transcripts have alternate 5' utr structure which results from spli ... | 2011 | 21638026 |
| increased thyroidal t4 to t3 conversion in autonomously functioning thyroid adenoma: from euthyroidism to thyrotoxicosis. | aim: the aim was to investigate whether the intrathyroid conversion of t4 to t3 in autonomously functioning thyroid adenoma (afta) tissue could influence serum t3 levels and suppression of tsh, especially in patients with borderline thyroid function. patients and methods: in ten patients with afta, thyroidal conversion of t4 to t3 was investigated in nodular and paranodular, tsh-suppressed tissue. all patients had normal serum t4 and suppressed tsh. serum t3 was normal in six, and borderline or ... | 2011 | 21640977 |
| effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy. | background maternal hypothyroidism (oh and sch) during early pregnancy is suspected to associate with adverse obstetrical outcomes. aim the aim of the present study was to investigate whether maternal subclinical hypothyroidism during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes. subjects and methods a total of 756 women in the first trimester (≤12 weeks) of pregnancy were enrolled through ten hospitals in sheny ... | 2011 | 21642766 |
| long-term response in advanced bladder cancer involving the use of temsirolimus and vinflunine after platin resistance. | relapse after initial first-line chemotherapy shows a poor prognosis in metastatic urothelial cancer. currently, several chemotherapeutic agents and targeted drugs are under evaluation for platin-resistant advanced urothelial carcinoma. vinflunine has been approved for second-line treatment in this indication. we present a patient with initial t4 advanced and subsequently metastasized bladder cancer, who has shown prolonged survival of 44 months after radical cystectomy. during her clinical cour ... | 2011 | 21642839 |
| interleukin-1{beta} (il-1{beta}) promotes susceptibility of toll-like receptor 5 (tlr5) deficient mice to colitis. | background the extent to which numerous strains of genetically engineered mice, including mice lacking toll-like receptor 5 (t5ko), display colitis is environment dependent. gut microbiota underlie much of the variation in phenotype. accordingly, embryonic rederivation of t5ko mice ameliorated their spontaneous colitis despite only partially correcting elevated proinflammatory gene expression. it was postulated that endogenous anti-inflammatory pathways mediated the absence of overt inflammation ... | 2011 | 21646247 |
| coordination of dna replication and recombination activities in the maintenance of genome stability. | across the evolutionary spectrum, living organisms depend on high-fidelity dna replication and recombination mechanisms to maintain genome stability and thus to avoid mutation and disease. the repair of severe lesions in the dna such as double-strand breaks or stalled replication forks requires the coordinated activities of both the homologous recombination and dna replication machineries. growing evidence indicates that so-called "accessory proteins" in both systems are essential for the effect ... | 2011 | 21647941 |
| [the effect of sevoflurane inhalation anesthesia only and propofol total intravenous anesthesia on perioperative cytokine balance in lung cancer patients]. | to investigate the effects of sevoflurane inhalation anesthesia only and propofol total intravenous anesthesia on perioperative cytokine balance in lung cancer patients. | 2011 | 21651869 |
| could thyroid dysfunction influence outcome in sunitinib-treated metastatic renal cell carcinoma? | background: sunitinib is a standard of care for metastatic renal cell carcinoma (mrcc). hypothyroidism is frequently observed under sunitinib therapy. this study was conducted to prospectively determine the correlation between thyroid function and progression-free survival (pfs) in this population. patients and methods: one hundred and eleven mrcc patients treated with sunitinib were evaluated for serum thyroid-stimulating hormone (tsh) and t4 levels before treatment and every 6 weeks during tre ... | 2011 | 21653681 |
| in ovo thyroxine exposure alters later uvs cone loss in juvenile rainbow trout. | thyroid hormones (ths) play a vital role in vertebrate neural development, and, together with the beta isoform of the thyroid hormone receptor (trβ), the development and differentiation of cone photoreceptors in the vertebrate retina. rainbow trout undergo a natural process of cone cell degeneration during development and this change in photoreceptor distribution is regulated by thyroxine (t4; a thyroid hormone). in an effort to further understand the role of t4 in photoreceptor ontogeny and lat ... | 2011 | 21653819 |
| minimum 5-year radiographic results of long scoliosis fusion in juvenile spinal muscular atrophy patients: major curve progression after instrumented fusion. | previous studies reported on spinal muscular atrophy (sma) scoliosis surgery outcomes without focus on major curve progression (mcp). the purpose of this study was to assess minimum 5-year radiographic outcomes, mcp, and factors for mcp after spinal surgery in juvenile sma patients with open triradiate cartilage at the time of surgery. | 2011 | 21654453 |
| effect of magnesium infusion on thoracic epidural analgesia. | patients of lung volume reduction surgery (lvrs) having an asa status iii or more are likely to be further downgraded by surgery to critical levels of pulmonary function. | 2011 | 21655018 |
| quick and clean cloning: a ligation-independent cloning strategy for selective cloning of specific pcr products from non-specific mixes. | we have developed an efficient strategy for cloning of pcr products that contain an unknown region flanked by a known sequence. as with ligation-independent cloning, the strategy is based on homology between sequences present in both the vector and the insert. however, in contrast to ligation-independent cloning, the cloning vector has homology with only one of the two primers used for amplification of the insert. the other side of the linearized cloning vector has homology with a sequence prese ... | 2011 | 21655102 |
| late onset pott's paraplegia in patients with upper thoracic sharp kyphosis. | purpose: the purpose of this study was to determine the clinical results of patients with late onset upper thoracic sharp pott's kyphosis and to predict the prognosis for pott's paraplegics. method: the study included five patients who developed late onset upper thoracic (t1-t4) sharp pott's kyphosis /kyphoscoliosis within a period from 19 to 37 years after the active disease was healed. the kyphosis angle of the patients ranged from 95° to 105°. among them, three patients suffered onset of para ... | 2011 | 21656306 |
| [hypothyroidism]. | hypothyroidism is one of the most frequent endocrine disorders affecting 4.6% of the adult population. 90% of the cases represent subclinical hypothyroidism, defined by increased serum tsh but normal free thyroxine (ft4) values. general screening for hypothyroidism is not recommended because of lack of benefits for the patients. search for hypothyroidism should therefore focus on patients with symptoms and signs and/or those presenting risk factors for development of hypothyroidism (e.g., autoim ... | 2011 | 21656490 |
| detection of 5-hydroxymethylcytosine in dna by transferring a keto-glucose by using t4 phage β-glucosyltransferase. | | 2011 | 21656634 |
| multivisceral resection for primary locally advanced rectal carcinoma. | pelvic multivisceral resection offers the possibility of cure in patients with locally advanced rectal cancer. this study assessed the clinical outcome and determinants of survival and local recurrence in patients undergoing multivisceral resection for clinical t4 primary rectal cancer. | 2011 | 21656723 |
| suppression of autophagy and activation of glycogen synthase kinase 3beta facilitate the aggregate formation of tau. | neurofibrillary tangle (nft) is a characteristic hallmark of alzheimer's disease. gsk3╬▓ has been reported to play a major role in the nft formation of tau. dysfunction of autophagy might facilitate the aggregate formation of tau. the present study examined the role of gsk3╬▓-mediated phosphorylation of tau species on their autophagic degradation. we transfected wild type tau (t4), caspase-3-cleaved tau at asp421 (t4c3), or pseudophosphorylated tau at ser396/ser404 (t4-2ec) in the presence of ac ... | 2011 | 21660151 |
| preoperative serum carbohydrate antigen 242 is a useful predictive and prognostic marker in colorectal cancer. | tumor markers (tm) play an important role in the management of colorectal cancer (crc). this study evaluates the predictive and prognostic value of preoperative serum carbohydrate antigen 242 (ca242) in crc. | 2011 | 21661399 |
| long-term survivors of esophageal carcinoma with distant lymph node metastasis. | clinical extra-regional lymph node metastasis, m1 lymph node metastasis (m1 lym), has been recognized as a far advanced condition in esophageal cancer. however, some patients with m1 lym survive long-term. the purpose of this study was to identify the clinicopathological features of those patients with m1 lym achieving long-term survival. | 2011 | 21661407 |
| mortality among men with locally advanced prostate cancer managed with noncurative intent: a nationwide study in pcbase sweden. | there are limited prognostic data for locally advanced prostate cancer pca to guide in the choice of treatment. | 2011 | 21664039 |
| pre-operative bevacizumab, capecitabine, oxaliplatin and radiation among patients with locally advanced or low rectal cancer: a phase ii trial. | background: to evaluate the safety and efficacy of pre-operative chemoradiation, using capecitabine, oxaliplatin and bevacizumab with standard doses of radiation, in patients with high-risk rectal cancer. methods: patients with locally advanced or low rectal cancer were treated with capecitabine 825mg/m(2) twice daily on days 1-14 and 22-35, oxaliplatin 50mg/m(2) on days 1, 8, 22 and 29, bevacizumab 5mg/kg on days 14, 1, 15 and 29, and radiation 50.4gy in 28 fractions including boost. total meso ... | 2011 | 21664123 |
| heterologous expression and purification of membrane-bound pyrophosphatases. | membrane-bound pyrophosphatases (m-ppases) are enzymes that couple the hydrolysis of inorganic pyrophosphate to pumping of protons or sodium ions. in plants and bacteria they are important for relieving stress caused by low energy levels during anoxia, drought, nutrient deficiency, cold and low light intensity. while they are completely absent in mammalians, they are key players in the survival of disease-causing protozoans making these proteins attractive pharmacological targets. in this work, ... | 2011 | 21664973 |
| efficacy of fluoro-2-deoxy-d-glucose positron emission tomography to evaluate responses to concurrent chemoradiotherapy for head and neck squamous cell carcinoma. | this study evaluates the utility of fluorodeoxyglucose-positron emission tomography (fdg-pet) in patients with head and neck squamous cell carcinoma (hnscc) who received concurrent chemoradiotherapy (ccrt). | 2011 | 21665394 |
| acute loading and aging effects on myostatin pathway biomarkers in human skeletal muscle after three sequential bouts of resistance exercise. | to determine the influence of age and resistance exercise on myostatin pathway-related genes, younger (n = 10; 28 -¦ 5 years) and older (n = 10; 68 -¦ 6 years) men underwent four testing conditions (t1-t4). a baseline (t1) muscle sample was obtained, whereas the second and third biopsies were obtained 48 hours following the first and second training sessions (t2, t3), and a final biopsy was taken 24 hours following t3. the training sessions consisted of 3 sets of 10 repetitions (80% of one repet ... | 2011 | 21665986 |
| phosphatase-like activity, dna binding, dna hydrolysis, anticancer and lactate dehydrogenase inhibition activity promoting by a new bis-phenanthroline dicopper(ii) complex. | a new bis-phenanthroline dicopper(ii) complex has been synthesized and characterized by elemental analysis and spectroscopic methods. the molecular structure of the dinuclear cu(ii) complex [cu(2)(╬╝-ch(3)coo)(╬╝-h(2)o)(╬╝-oh)(phen)(2)](2+) (phen = 1,10-phenanthroline) (1) was determined by single crystal x-ray diffraction technique. the coordination environment around each cu(ii) ion in complex 1 can be described as slightly distorted square pyramidal geometry. the distance between the cucu cen ... | 2011 | 21666926 |
| cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity. | the antiviral activities of poly(phenylene ethynylene) (ppe)-based cationic conjugated polyelectrolytes (cpe) and oligo-phenylene ethynylenes (ope) were investigated using two model viruses, the t4 and ms2 bacteriophages. under uv/visible light irradiation, significant antiviral activity was observed for all of the cpes and opes; without irradiation, most of these compounds exhibited high inactivation activity against the ms2 phage and moderate inactivation ability against the t4 phage. transmis ... | 2011 | 21667949 |
| idiopathic primary ovarian insufficiency: a study of serial hormonal profiles to assess ovarian follicular activity. | ovarian follicular activity in serial hormone profiles has been reported in up to 86% of patients with primary ovarian insufficiency (poi). in most of these studies, patients had a short duration of amenorrhea or irregular menstrual cycles which could influence the occurrence of spontaneous follicular activity. the aim was to study the incidence of follicular activity in serial hormonal profiles of women with spontaneous poi and amenorrhea of 1 year duration. | 2011 | 21669968 |
| the ability of phased-array mri in preoperative staging of primary rectal cancer: correlation with histopathological results. | purpose: this study evaluated the accuracy of phased-array mri for preoperative local tumor staging in primary rectal cancer and emphasized the importance of the preoperative differentiation of t2 tumors from t3 tumors so the appropriate treatment can be applied. materials and methods: twenty-four patients with primary rectal cancer were examined preoperatively using 1.5-t magnetic resonance imaging with a phased-array coil. multiplanar t2-weighted images were obtained. rectum anatomy, depth of ... | 2011 | 21671218 |
| vertebral morphometry by x-ray absorptiometry: which reference data for vertebral heights? | the recent improvement in the resolution of dual-energy x-ray absorptiometry (dxa) images enables most vertebral levels to be seen adequately and thus dxa may be a worthwhile alternative to radiologic morphometry for the identification of vertebral fractures (vf). in this multicenter study, we have derived reference data for vertebral heights and their ratios in italian women using morphometric x-ray absorptiometry (mxa). | 2011 | 21672644 |
| [combined transplantation of a free skin island flap supplied by a septo-cutaneous perforator of the posterior tibial artery and the underlying fibula for the full reconstruction of the mandible and the mouth floor]. | microsurgical transplantation of the osteo-cutaneous fibula as a free flap to reconstruct the defect following radical resection of a mouth floor's tumor is a well-known and often applied procedure. anatomy of the vessels supplying this flap is recognized but it may have some rare and unexpected variations. in this case report we discuss the reconstruction of the middle and lateral parts of the mandible which was resected due to a t4 gingival tumor. interestingly, the aforementioned segment of t ... | 2011 | 21672684 |
| vertebral body stapling as an alternative in the treatment of idiopathic scoliosis. | unilateral vertebral body stapling as a fusionless alternative to control curvature progression in patients with idiopathic scoliosis (is). | 2011 | 21674182 |
| survival and quality of life following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis of colonic origin. | background: peritoneal carcinomatosis of colonic origin (pcc) is a life-threatening diagnosis. cytoreductive surgery (cs) with hyperthermic intraperitoneal chemotherapy (hipec) offers patients the prospect of long-term survival with alleviation of symptoms. methods: patients underwent hipec for pcc and completed questionnaires preoperatively (t1) and after surgery at 3 (t2), 6 (t3), and 12 (t4) months. questionnaires included the functional assessment of cancer therapy-colon (fact-c), brief pain ... | 2011 | 21674272 |
| nick sealing by t4 dna ligase on a modified dna template: tethering a functional molecule on d-threoninol. | efficient dna nick sealing catalyzed by t4 dna ligase was carried out on a modified dna template in which an intercalator such as azobenzene had been introduced. the intercalator was attached to a d-threoninol linker inserted into the dna backbone. although the structure of the template at the point of ligation was completely different from that of native dna, two odns could be connected with yields higher than 90 % in most cases. a systematic study of sequence dependence demonstrated that the l ... | 2011 | 21815224 |
| intuitive visualization and quantification of intraventricular convection in acute ischemic left ventricular failure during early diastole using color doppler-based echocardiographic vector flow mapping. | the aim of this study was to make an intuitive visualization of intraventricular convection (ic) and quantification of intraventricular convection velocity (icv) in acute ischemic left ventricular (lv) failure of open-chest canines during early diastole contrast to the baseline conditions using color doppler-based echocardiographic vector flow mapping (vfm). the animal care committee approved this prospective study. in 6 anesthetized open-chest beagle models, the emergence time and the emergence ... | 2011 | 21814809 |
| spinal intramedullary cysticercosis: a case report and literature review. | neurocysticercosis, involvement of the central nervous system by taenia solium, is one of the most common parasitic diseases of the cns. however, spinal involvement by neurocysticercosis is uncommon. here, we reported a 40-year-old woman with intramedullary cysticercosis in the thoracic spinal cord. mri revealed two well-defined round intramedullary lesions at t4 and t5 vertebral levels, which were homogeneously hypointense on t1wi and hyperintense on t2wi with peripheral edema. since the patien ... | 2011 | 21814474 |
| developmental treatment with bisphenol a or ethinyl estradiol causes few alterations on early preweaning measures. | since bisphenol a (bpa) exposure is nearly ubiquitous, increased knowledge of its potential effects on development will enable better risk assessment and regulatory guidance. here, sprague-dawley rats were reared in low exogenous estrogen environments. after breeding at adulthood, dams were gavaged on gestational days (gds) 6-21 with vehicle (veh), 2.5 or 25.0 μg/kg/day bpa, or 5.0 or 10.0 μg/kg/day ethinyl estradiol (ee(2)). offspring were orally treated on pnds 1-21 with the same dose the dam ... | 2011 | 21813462 |
| [intervention of astragalus injection on the kidney injury after cardiopulmonary bypass of infants with congenital heart disease]. | to study the intervention of astragalus injection in the kidney injury of infants with congenital heart disease after cardiopulmonary bypass, thus providing a new method for protection of the kidney injury in them. | 2011 | 21812263 |
| challenges in the management of stage ii colon cancer. | approximately one third of patients diagnosed with early-stage colon cancer will present with lymph node involvement (stage iii) and about one quarter with transmural bowel wall invasion but negative lymph nodes (stage ii). adjuvant chemotherapy targets micrometastatic disease to improve disease-free (dfs) and overall survival (os). while beneficial for stage iii patients, the role of adjuvant chemotherapy is unestablished in stage ii disease. this likely relates to the improved outcome of these ... | 2011 | 21810510 |
| [effects of lys-glu-asp-gly and ala-glu-asp-glypeptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds]. | the aim of the paper was to investigate effects of lys-glu-asp-gly and ala-glu-asp-gly peptides which were designed and synthesized on the basis of amino acid study of the hypophyseal anterior and posterior lobe peptides on the thyroid morphology and hormonal activity in mature chicken and old birds. hypophysectomy was established to produce atrophic changes in the thyroid gland and development of secondary hypothyrosis. administration of lys-glu-asp-gly and ala-glu-asp-gly tetrapeptides signifi ... | 2011 | 21809626 |
| transform and relax sampling for highly anisotropic systems: application to protein domain motion and folding. | transform and relax sampling (trs) is proposed as a conformational sampling method to enhance "soft" fluctuation in highly anisotropic systems using molecular dynamics simulation. this method consists of three stages; transform, relax, and sampling. in the transform stage, molecular dynamics simulation is performed with randomly assigned force bias to enhance the fluctuations along relatively soft collective movements, as expected from the linear response theory. after relaxing the heated system ... | 2011 | 21806159 |
| trans-placental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones. | while the results of animal studies have shown that perfluorinated compounds (pfcs) can modulate concentrations of thyroid hormones in blood, limited information is available on relationships between concentrations of pfcs in human blood serum and fetal thyroid hormones. the relationship between concentrations of pfcs in blood and fetal thyroid hormone concentrations or birth weight, and ratios of major pfcs between maternal and fetal serum were determined. concentrations of pfcs were measured i ... | 2011 | 21805959 |
| intracellular detection of cytosine incorporation in genomic dna by using 5-ethynyl-2'-deoxycytidine. | 5-ethynyl-2'-deoxycytidine triphosphate (edctp) was synthesized as a probe to be used in conjunction with fluorescent labeling to facilitate the analysis of the in vivo dynamics of dna-centered processes (dna replication, repair and cytosine demethylation). kinetic analysis showed that edctp is accepted as a substrate by klenow exo(-) and dna polymerase ß. incorporation of 5-ethynyl-2'-deoxycytidine (edc) into dna by these enzymes is, at most, modestly less efficient than native dc. edc-containi ... | 2011 | 21805552 |
| comparison of two ventilation modes in post-cardiac surgical patients. | the cardiopulmonary bypass (cpb)-associated atelectasis accounted for most of the marked post-cpb increase in shunt and hypoxemia. we hypothesized that pressure-regulated volume-control (prvc) modes having a distinct theoretical advantage over pressure-controlled ventilation (pcv) by providing the target tidal volume at the minimum available pressure may prove advantageous while ventilating these atelactic lungs. | 2011 | 21804799 |
| thyroid function in children with nephrotic syndrome. | this study was done to find out the thyroid function of nephrotic children during nephrosis and to compare any significant changes of thyroid function status during nephrosis and remission. this is an observational study with prospective follow up of study subjects. it was carried out over a period of one year from july'2006 to june'2007 in the department of paediatric nephrology, national institute of kidney diseases & urology (nikdu), dhaka, bangladesh. a total of 85 nephrotic children with in ... | 2011 | 21804503 |
| dissociated time course of recovery between genders after resistance exercise. | flores, df, gentil, p, brown, le, pinto, rs, carregaro, rl, and bottaro, m. dissociated time course of recovery between genders after resistance exercise. j strength cond res 25(x): 000-000, 2011-comparisons between men and women of time course responses of strength, delayed-onset muscle soreness (doms), and muscle swelling after a resistance training session are still controversial. therefore, this study examined gender differences in strength loss, muscle thickness (mt), and doms between young ... | 2011 | 21804429 |
| manserin as a novel histochemical neuroendocrine marker in prostate cancer. | objectives: to investigate the presence of manserin in human prostate cancers and to correlate manserin expression with pathologic outcomes and progression-free survival. methods: eighty-seven patients with recent prostate cancer were classified into 4 groups based on gleason score, and manserin immunohistochemistry was correlated with gleason sum grade. to investigate the validity of manserin as a prognostic factor, the cox proportional hazards regression model was performed on 48 patients in o ... | 2011 | 21803620 |
| cephalometric evaluation in different phases of jasper jumper therapy. | the aim of this study was to evaluate the dentoskeletal and soft-tissue effects of class ii malocclusion treatment with the jasper jumper followed by class ii elastics at the different stages of therapy. | 2011 | 21803237 |
| leptin-programmed rats respond to cold exposure changing hypothalamic leptin receptor and thyroid function differently from cold-exposed controls. | we showed that neonatal leptin treatment programmes for hyperleptinemia and central leptin resistance both at 30days-old and adulthood, while programmes for lower serum t3 at 30days-old, but higher thyroid hormones (th) at adulthood. as in these animals, acute cold at 30days-old normalized leptinemia and restored the expression of hypothalamic leptin receptor (obr), here we evaluate the effect of cold exposure on the thyroid function and obr in adult rats programmed by neonatal hyperleptinemia. ... | 2011 | 21803077 |
| eus and magnetic resonance imaging in the staging of rectal cancer: a prospective and comparative study. | accurate locoregional staging is crucial in rectal cancer for deciding patient management because the administration of neoadjuvant therapy depends on it. eus and magnetic resonance imaging (mri) are used indistinctly in the pretherapeutic workup of rectal cancer. | 2011 | 21802588 |
| boty-like retrotransposons in the filamentous fungus botrytis cinerea contain the additional antisense gene brtn. | long-terminal repeat (ltr) retrotransposons typically contain gag, pol, or gag-pol, and in some case env genes. in this work, we used data mining of the botrytis cinerea genomic sequence and a molecular approach to identify boty-like ltr retrotransposons in b. cinerea containing an antisense gene (brtn) between pol and the 3'-ltr. reverse transcriptase pcr (rt-pcr) revealed that some brtn-like genes could be expressed, at least in b. cinerea t4. we conducted blast comparisons and conserved-domai ... | 2011 | 21802103 |
| zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis. | thyroxine-immunofluorescence quantitative disruption test (tiqdt) was designed to provide a simple, rapid, alternative bioassay for assessing the potential of chemical pollutants and drugs to disrupt thyroid gland function. this study demonstrated that zebrafish eleutheroembryos provided a suitable vertebrate model, not only for screening the potential thyroid disrupting effect of molecules, but also for estimating the potential hazards associated with exposure to chemicals directly impairing th ... | 2011 | 21800831 |
| molecular detection and comparison of acanthamoeba genotypes in different functions of watersheds in taiwan. | the protistan genus acanthamoeba is a free-living amoeba existing in various environments. within this protistan genus, there are some species recognized as potential human pathogens, which may cause granulomatous amoebic encephalitis, acanthamoeba keratitis and chronic granulomatous lesions of the skin. in this study, 211 water samples were collected from two watersheds in southern taiwan. we detected acanthamoeba based on the pcr amplification with a genus-specific primer pair and investigatio ... | 2011 | 21800062 |
| thyroid gland invasion in laryngopharyngeal squamous cell carcinoma: prevalence, endoscopic and ct predictors. | objectives: the authors studied the prevalence of histological thyroid gland invasion in laryngopharyngeal cancer and the preoperative endoscopic and ct signs predictive of this invasion. patients and methods: retrospective study of patients with laryngopharyngeal squamous cell carcinoma (t3 and t4) treated by total laryngectomy or total laryngopharyngectomy associated with concomitant total thyroidectomy or ipsilateral lobectomy and isthmectomy. results: eighty-seven patients were included. ele ... | 2011 | 21798840 |
| metastatic prostate cancer in ossification of the ligamentum flavum-a case report. | background context: no previous reports have described a metastatic tumor located in the ossification of the ligamentum flavum (olf). purpose: to report an extremely rare case of metastatic tumor located in the olf. study design: case report. methods: we report a case of a 54-year-old man who sustained paraparesis attributable to spinal cord compression because of olf in the thoracic spine. results: the olf at t3/t4 and t5/t6, together with the laminae of t3-t6, was resected. histologically, the ... | 2011 | 21798814 |
| application of endoscopic sonography in preoperative staging of rectal cancer: six-year experience. | objectives- the aim of this study was to evaluate our experience with the application of endoscopic sonography in preoperative staging of rectal cancer. methods- between april 2004 and may 2010, 192 patients with rectal cancer first underwent endoscopic sonography and then underwent surgery at our hospital. none of the patients in this study received neoadjuvant therapy. the endoscopic sonographic staging results were compared with those of postoperative pathologic staging. results- the accuracy ... | 2011 | 21795480 |
| screw motion regulates multiple functions of t4 phage protein gp5 during cell puncturing. | bacteriophage t4 penetrates the outer membrane of escherichia coli using a multifunctional device composed of a gene product 5 (gp5) protein trimer. we report that gp5 sequentially exerts distinct functions along the course of penetration stages induced by screw motion. a triple-stranded ß-helix of gp5 act as a cell-puncturing drill bit to make a hole on the membrane and then send the lipids upwards efficiently by strong charge interactions. the gp5 lysozyme domains, which degrade the peptidogly ... | 2011 | 21793574 |
| relevance of both individual risk factors and occupational exposure in cancer survival studies: the example of intestinal type sinonasal adenocarcinoma. | objectives/hypothesis: wood dust is a well-established risk factor for intestinal type sinonasal adenocarcinoma. the 5-year overall survival has varied from 20% to 80% according t1-t4 stages; 5-year survival according to histologic subtype has varied from 20% to 50%. to date, no study has evaluated whether environmental, occupational, and personal risk factors have any impact on both overall and cancer-specific survival. we aimed to determine whether exposure to carcinogenic risk factors besides ... | 2011 | 21792978 |