| pure red cell aplasia due to b19 parvovirus infection after autologous stem cell transplantation. | parvovirus b19 is recognized as a rare cause of pure red cell aplasia (prca) in allogeneic stem cell (sct) and solid organ transplant patients. we report a patient with hodgkin's disease who developed prca due to parvovirus b19 after autologous sct and who had an excellent response after treatment with gamma-globulin. | 2011 | 23198254 |
| small bowel fistula and its impact: incorrect placement of left ventricular assist device cannulas leads to severe intestinal complications. | a young man presented with a chronic abdominal dermal irritation 4 years after implantation of a left ventricular assist device (lvad; berlin heart excor). the lvad was needed because of end-stage heart failure following a chronic parvovirus b19 infection. the implantation of mechanical circulatory support systems (mcs) has nowadays become an accepted treatment modality for patients with end-stage heart failure. recent literature shows several intestinal complications related to mcs, but no case ... | 2011 | 22679225 |
| [secondary autoimmune hemolytic anemia as a result of b19 parvovirus persistence in immunodeficient patients]. | to ascertain informative value of immunological diagnosis of b19 parvovirus in combination with polymerase chain reaction (pcr); to analyse frequency of development of secondary autoimmune hemolytic anemia (aiha) in immunodeficient patients as a result of virus persistence--persistent infection eliminated only by treatment causing suppression of erythropoiesis. | 2011 | 22416448 |
| [parvovirus b19 arthritis: report of three cases]. | parvovirus b19 infection is highly prevalent in children and the most common manifestation is a facial rash. in adults, acute polyarthritis and skin rash are often the presenting features. we report three patients with the disease. a 40-year-old female presenting with fever, myalgias and painful swelling of elbows, knees, wrists and feet, with functional limitation, after having a respiratory infection. additionally, an erythematous skin rash appeared in both extremities. igm antibodies against ... | 2012 | 23677193 |
| [collapsing glomerulopathy]. | collapsing glomerulopathy is a cause of nephrotic syndrome with massive proteinuria secondary to podocyte proliferation and glomerular collapse. it is characterized by an almost inevitable progression to end stage renal failure, poor response to treatment and high post-transplant recurrence. its frequency has increased in recent years due to its common association with human immunodeficiency virus (hiv) infection and the growing recognition of new etiologic agents such as drugs and parvovirus b1 ... | 2012 | 23559294 |
| pure red cell aplasia caused by parvo b19 virus in a kidney transplant recipient. | parvo b19 is a single stranded dna virus, which typically has affinity for erythroid progenitor cells in the bone marrow and produces a severe form of anemia known as pure red cell aplasia. this condition is particularly worse in immunocompromised individuals. we herein report a young nepali male who developed severe and persistent anaemia after kidney transplantation while being on immunosuppressive therapy. his bone marrow examination revealed morphological changes of pure red cell aplasia, ca ... | 2012 | 23478734 |
| viruses and collapsing glomerulopathy: a brief critical review. | background: collapsing glomerulopathy may occur in an idiopathic (primary) form and in association with a wide spectrum of infectious and inflammatory conditions and medications. the association of collapsing glomerulopathy with human immunodeficiency virus (hiv)-1 infection is well established; less certain is the association with other viral infections. methods: we searched pubmed for articles in all languages that addressed glomerulopathies associated with parvovirus b19, cytomegalovirus (cmv ... | 2012 | 23372939 |
| [acute liver failure due to human herpesvirus 6 in an infant]. | we report a case of a 4-months infant with fever in the absence of other specific symptoms that has rapidly and unexpectedly developed acute liver failure (alf) with coagulopathy and complicated with bone marrow failure without encephalopathy. the main viral infection agents (hepatitis virus a, b, c, citomegalovirus, ebstain barr virus, parvovirus b19, adenovirus), drug-induced hepatotoxicity and metabolic disorders associated to alf were excluded. quantitative determination of human herpesvirus ... | 2012 | 23342747 |
| a case report on parvovirus b19 associated myositis. | introduction. whilst there are reports of viral myopathies affecting children and the immunocompromised, infective myositis is a relatively rare inflammatory myopathy in adults. the clinical spectrum can range from benign myalgias to more serious complications in certain risk groups. case presentation. we present two cases of myositis as a result of parvovirus b19 infection. conclusion. viral myositis and parvovirus b19 associated myositis should be considered in adults presenting with significa ... | 2012 | 23304613 |
| [parvovirus b19 infection-associated pleural effusion]. | | 2012 | 23273759 |
| severe anemia in papua new guinean children from a malaria-endemic area: a case-control etiologic study. | there are few detailed etiologic studies of severe anemia in children from malaria-endemic areas and none in those countries with holoendemic transmission of multiple plasmodium species. | 2012 | 23272266 |
| parvovirus b19-induced constellation of acute renal failure, elevated aminotransferases and congestive heart failure. | this report details a case of acute renal failure and elevated aminotransferases with subsequent development of congestive heart failure in a patient with history of exposure to parvovirus b19 and serological evidence of acute infection with this agent. this constellation of organ involvement has not been previously reported in the literature. | 1997 | 22514477 |
| influence of infection during pregnancy on fetal development. | infection by bacteria, viruses, and parasites may lead to fetal death, organ injury, or limited sequelae depending on the pathogen. here, we consider the role of infection during pregnancy in fetal development including placental development and function, which can lead to fetal growth restriction. the classical group of teratogenic pathogens is referred to as 'torch' (toxoplasma gondii, others like treponema pallidum, rubella virus, cytomegalovirus, and herpes simplex virus) but should include ... | 2013 | 23884862 |
| the role of infection in miscarriage. | miscarriage is the spontaneous loss of a pregnancy before 12 weeks (early miscarriage) or from 12 to 24 weeks (late miscarriage) of gestation. miscarriage occurs in one in five pregnancies and can have considerable physiological and psychological implications for the patient. it is also associated with significant health care costs. there is evidence that potentially preventable infections may account for up to 15% of early miscarriages and up to 66% of late miscarriages. however, the provision ... | 2015 | 26386469 |
| guillain-barré syndrome associated with primary parvovirus b19 infection in an hiv-1-infected patient. | parvovirus b19 (b19v) infection has rarely been reported as responsible for guillain-barré syndrome (gbs). we present the case of a 63-year-old man with aids who presented with rapidly progressing weakness of his inferior limbs and a newly appeared pancytopenia. csf examination and electromyography were characteristic for gbs. very high csf and serum b19v dna concentrations were present, in the absence of igg or igm against b19v. the neurologic and hematologic abnormalities improved after a 5-da ... | 2012 | 23251163 |
| neurological aspects of human parvovirus b19 infection: a systematic review. | parvovirus b19 has been linked with various clinical syndromes including neurological manifestations. however, its role in the latter remains not completely understood. although the last 10 years witnessed a surge of case reports on b19-associated neurological aspects, the literature data remains scattered and heterogeneous, and epidemiological information on the incidence of b19-associated neurological aspects cannot be accurately extrapolated. the aim of this review is to identify the characte ... | 2014 | 24459081 |
| acute polyarthritis in a young patient caused by meningococcal and parvovirus b19 infections: a case report and review of the literature. | meningococcal infection is a multifaceted disease including acute polyarthritis. this presentation should be known by clinicians in order to prevent delay in treatment. we report what we believe to be the first case of an association of parvovirus b19 and meningococcal polyarthritis in a young adult. | 2016 | 27998301 |
| viral arthritis. | acute-onset arthritis is a common clinical problem facing both the general clinician and the rheumatologist. a viral aetiology is though to be responsible for approximately 1% of all cases of acute arthritis with a wide range of causal agents recognised. the epidemiology of acute viral arthritis continues to evolve, with some aetiologies, such as rubella, becoming less common due to vaccination, while some vector-borne viruses have become more widespread. a travel history therefore forms an impo ... | 0 | 27037381 |
| current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections. | in august 2009, a group from the aabb (stramer et al., transfusion 2009;99:1s-29s, emerging infectious disease agents and their potential threat to transfusion safety; http://www.aabb.org/resources/bct/eid/pages/default.aspx) published a supplement to transfusion that reviewed emerging infectious disease (eid) agents that pose a real or theoretical threat to transfusion safety, but for which an existing effective intervention is lacking. the necessary attributes for transfusion transmission were ... | 2014 | 25210533 |
| virus detection and semiquantitation in explanted heart tissues of idiopathic dilated cardiomyopathy adult patients by use of pcr coupled with mass spectrometry analysis. | viral detection in heart tissues has become a central issue for the diagnosis and exploration of the pathogenesis of idiopathic dilated cardiomyopathy (idcm). in the present study, common cardiotropic viruses in 67 explanted heart samples of 31 idcm adult patients were detected and semiquantified by using for the first time a new technology based on pcr assay coupled to electrospray ionization-time of flight mass spectrometry analysis (pcr-ms), with comparison to reference quantitative real-time ... | 2013 | 23658274 |
| human parvovirus b19 and blood product safety: a tale of twenty years of improvements. | | 0 | 25849894 |
| conserved b-cell epitopes among human bocavirus species indicate potential diagnostic targets. | human bocavirus species 1-4 (hbov1-4) have been associated with respiratory and enteric infections in children. however, the immunological mechanisms in response to hbov infections are not fully understood. though previous studies have shown cross-reactivities between hbov species, the epitopes responsible for this phenomenon remain unknown. in this study, we used genomic and immunologic approaches to identify the reactive epitopes conserved across multiple hbov species and explored their potent ... | 2014 | 24475201 |
| virological diagnosis of central nervous system infections by use of pcr coupled with mass spectrometry analysis of cerebrospinal fluid samples. | viruses are the leading cause of central nervous system (cns) infections, ahead of bacteria, parasites, and fungal agents. a rapid and comprehensive virologic diagnostic testing method is needed to improve the therapeutic management of hospitalized pediatric or adult patients. in this study, we assessed the clinical performance of pcr amplification coupled with electrospray ionization-time of flight mass spectrometry analysis (pcr-ms) for the diagnosis of viral cns infections. three hundred twen ... | 2013 | 24197874 |
| central nervous system richter's transformation and parvovirus b19 infection. | | 2013 | 23320889 |
| the national heart, lung, and blood institute retrovirus epidemiology donor studies (retrovirus epidemiology donor study and retrovirus epidemiology donor study-ii): twenty years of research to advance blood product safety and availability. | the retrovirus epidemiology donor study (reds), conducted from 1989 to 2001, and the reds-ii, conducted from 2004 to 2012, were national heart, lung, and blood institute-funded, multicenter programs focused on improving blood safety and availability in the united states. the reds-ii also included international study sites in brazil and china. the 3 major research domains of reds/reds-ii have been infectious disease risk evaluation, blood donation availability, and blood donor characterization. b ... | 2012 | 22633182 |
| the etiology of juvenile idiopathic arthritis. | over the years, the commonly used term to describe juvenile idiopathic arthritis (jia) has changed. by definition, jia includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. jia pathogenesis is still poorly understood: the interaction between environmental factors and multiple genes has been proposed as the most relevant working mechanism to the development of jia. the concept that various microbes that colonize or infect ... | 2015 | 25384710 |
| causative agents of kikuchi-fujimoto disease (histiocytic necrotizing lymphadenitis): a meta-analysis. | kikuchi-fujimoto disease (kfd) is a self-limiting disorder characterized by histiocytic necrotizing lymphadenitis in the cervical lymph nodes of young women. although an infectious etiology has been postulated, a definitive causative agent has not been identified. the few dozens of published studies are limited by small sample size and poorly structured study designs. the purpose of this study is to evaluate the association of each infectious agent to kfd that has been studied. | 2014 | 25200851 |
| coexistence of epstein-barr virus and parvovirus b19 in tonsillar tissue samples: quantitative measurement by real-time pcr. | in this study, we aimed to investigate the presence and copy number of six different viruses in tonsillar tissue samples removed surgically because of chronic recurrent tonsillitis or chronic obstructive tonsillar hypertrophy. | 2014 | 24882454 |
| detection of borrelia burgdorferi sensu lato in endomyocardial biopsy specimens in individuals with recent-onset dilated cardiomyopathy. | recent studies in patients with dilated cardiomyopathy (dcm) have detected the genome of borrelia burgdorferi sensu lato (bbsl) in endomyocardial biopsy (emb) specimens using a qualitative polymerase chain reaction (pcr), suggesting a causal link between lyme disease and dcm in areas in which lyme disease is endemic. we aimed to study this relationship using a comprehensive molecular analysis detecting bbsl in emb samples. | 2012 | 22379178 |
| suspected inflammatory cardiomyopathy. prevalence of borrelia burgdorferi in endomyocardial biopsies with positive serological evidence. | cardiac involvement in lyme disease, caused by the tick-borne spirochete borrelia burgdorferi, has been reported to occur in 0.3-4 % of infected patients in europe. cardiac manifestations may include conduction disturbances, and also myocarditis, pericarditis, and left ventricular dysfunction. we investigated the prevalence of b. burgdorferi dna in endomyocardial biopsies from patients with suspected inflammatory heart disease and positive serology for b. burgdorferi. | 2015 | 24938220 |
| genomic features of the human bocaviruses. | the human bocavirus (hbov) was initially discovered in 2005 as the second pathogenic member of the parvovirus family, next to the human parvovirus b19. hbov has since been shown to be extremely common worldwide and to cause a systemic infection in small children often resulting in respiratory disease. three more, presumably enteric, human bocaviruses (hbov2-4) have been identified in stool samples. parvoviruses are assumed to replicate via their genomic terminal hairpin-like structures in a so-c ... | 2012 | 22389649 |
| parvovirus infection-induced dna damage response. | parvoviruses are a group of small dna viruses with ssdna genomes flanked by two inverted terminal structures. due to a limited genetic resource they require host cellular factors and sometimes a helper virus for efficient viral replication. recent studies have shown that parvoviruses interact with the dna damage machinery, which has a significant impact on the life cycle of the virus as well as the fate of infected cells. in addition, due to special dna structures of the viral genomes, parvoviru ... | 2013 | 25429305 |
| detection and sequencing of zika virus from amniotic fluid of fetuses with microcephaly in brazil: a case study. | the incidence of microcephaly in brazil in 2015 was 20 times higher than in previous years. congenital microcephaly is associated with genetic factors and several causative agents. epidemiological data suggest that microcephaly cases in brazil might be associated with the introduction of zika virus. we aimed to detect and sequence the zika virus genome in amniotic fluid samples of two pregnant women in brazil whose fetuses were diagnosed with microcephaly. | 2016 | 26897108 |
| igg subclass profiles in normal human sera of antibodies specific to five kinds of microbial antigens. | the levels of subclass-specific immunoglobulin g (igg) antibodies to five microbial antigens in normal human sera were measured by enzyme-linked immunosorbent assays (elisa). the aim was to compare the igg subclass profiles of specific antibodies to diverse antigens originating from virus, intra- and extracellular bacteria. serum samples from 162 danish women were analyzed for igg1, igg2, igg3, and igg4 antibodies against a peptide of the major outer membrane protein (momp) of chlamydia trachoma ... | 2013 | 23620184 |
| [new approach in diagnostic algorithm of an infectious agents (parvovirus b19 and chlamydia trachomatis) involved in the development of pathological pregnancy]. | viral infections during pregnancy, along with some form of accompanying pregnancy diseases such as diabetes, cardiovascular, gastrointestinal, kidney and others, are a major cause of arising complications and mortality of mother and fetus. | 2016 | 27514136 |
| immunohistochemical search for viral and bacterial antigens in crohn's disease. | recent studies show that diseased intestinal tissues of patients with crohn's disease (cd) contain obstructed lymphatics, granulomas, and tertiary lymphoid organs, representing responses to persistent antigen. | 2013 | 22537638 |
| serum level of c-reactive protein is not a parameter to determine the difference between viral and atypical bacterial infections. | c-reactive protein (crp) is an acute-phase reactant that increases in the circulation in response to a variety of inflammatory stimuli. elevated levels in serum during several infectious diseases have been reported. in this study, a highly sensitive crp enzyme immunoassay was used to evaluate serum crp values in patients with viral and atypical bacterial infections. patients (n = 139) with different viral or atypical bacterial infections (systemic or respiratory) and healthy controls (n = 40) we ... | 2016 | 26241406 |
| notes from the field: outbreak of hand, foot, and mouth disease caused by coxsackievirus a6 among basic military trainees - texas, 2015. | on july 7, 2015, a man aged 22 years reported to sick call during basic military training at lackland air force base (afb), texas. he had erythematous, crusted papulovesicular lesions on the extensor surfaces of the upper and lower extremities. the patient was afebrile and otherwise well, and was evaluated later that day by the dermatology service. a viral infection was considered most likely because of the patient's age, absence of fever or constitutional symptoms, and the distribution and morp ... | 2016 | 27388434 |
| lymphocytes infiltrate the quadriceps muscle in lymphocytic myocarditis patients: a potential new diagnostic tool. | diagnosing lymphocytic myocarditis (lm) is challenging because of the large variation in clinical presentation and the limitations inherent in current diagnostic tools. the objective of this study was to analyze infiltration of inflammatory cells in quadriceps skeletal muscle of lm patients and investigate the potential diagnostic value of assaying infiltrating inflammatory cells. | 2014 | 25442457 |
| virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex pcr assay. | several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-hsct) are frequent, but viral reactivations after autologous hsct (auto-hsct) have not been investigated in detail. we performed multiplex polymerase chain reaction (pcr) assay to examine multiple viral reactivations simultaneously in 24 patients undergoing auto-hsct between september 2010 and december 2012. weekly whole blood samples were collected from pre- to 42 days post ... | 2017 | 27364410 |
| bk virus nephropathy is not always alone. | bk virus associated allograft nephropathy (bkvan) is an important cause of allograft lost that often occurs in the first year of transplantation. the state of over immunosuppression also predispose these patients to various opportunistic viral infection objectives: this research aimed to study the renal transplanted patients for bk viremia and bkvan. | 2016 | 27069959 |
| cervical lymphadenopathies in children: a prospective clinical cohort study. | cervical lymphadenopathy (lap) is a common sign and may raise fears about serious illnesses. the aim of our study was to evaluate the patients with cervical laps in a general pediatrics clinic setting, and to evaluate follow-up results for potential causes and risk factors for malignancies. | 2016 | 26857321 |
| clinical significance of viral genome persistence in the myocardium of patients with dilated cardiomyopathy. | the impact of myocardial viral persistence on the clinical outcome of patients with dilated cardiomyopathy (dcm) is still open to question. | 2015 | 26845221 |
| the prevalence of infectious agents in patients with systemic sclerosis. | systemic sclerosis (ssc) is an autoimmune disease characterized by microvascular injury, excessive extracellular matrix deposition, and fibrosis in the skin and internal organs. bacterial and viral infectious agents have been suspected to be contributing factors in the development and progression of the pathologic features of ssc. | 2015 | 26775370 |
| evaluation of a standardised real-time pcr based dna-detection method (realstar®) in whole blood for the diagnosis of primary human cytomegalovirus (cmv) infections in immunocompetent patients. | cytomegalovirus (cmv) dna detection in blood could, as a supplementary test to serology, improve the accuracy and speed of diagnosis of an acute cmv infection. in this study we evaluated the performance of a commercially available and standardised cmv pcr assay in whole blood for the diagnosis of a primary infection in immunocompetent adults. moreover, the kinetics of viral dna was evaluated in order to provide a time frame in which viral dna could be detected during an acute primary infection. ... | 2016 | 26661089 |
| antepartum screening for maternal infection and immune status: is it time to broaden our routine? | maternal infections with pvb19, hcv, cmv, and hiv during the antepartum period are important health problems for which the technological capacities for screening and diagnosis during the antepartum period are available. each of these viruses requires individual consideration for inclusion in screening and for the method of screening during the antepartum period. the availability of efficacious treatments for hcv and cmv, with demonstrable benefits to the mother or fetus, is required before antep ... | 2015 | 26637086 |
| time-series analysis comparing the prevalence of antibodies against nine viral species found in umbilical cord blood in japan. | in this study, we investigated the prevalence of antibodies against 9 viral species found in umbilical cord blood from 561 neonates in 2013. serum igg antibodies against the following viruses were measured: herpes simplex virus (hsv), varicella-zoster virus (vzv), epstein-barr virus (ebv), cytomegalovirus (cmv), human herpesvirus 6 (hhv-6), measles virus (mv), rubella virus (rv), mumps virus (muv), and human parvovirus b19 (hpv b19). a survey questionnaire regarding past medical history and mate ... | 2016 | 26567842 |
| detection of cytomegalovirus, human parvovirus b19, and herpes simplex virus-1/2 in women with first-trimester spontaneous abortions. | the relationship between viral infections and first-trimester spontaneous abortions is not well-understood. the study aim was to investigate the prevalence of cytomegalovirus (cmv), human parvovirus b19 (b19v), and herpes simplex virus-1/2 (hsv-1/2) infection by molecular and serological techniques in women experiencing spontaneous miscarriage in the first trimester of pregnancy. plasma samples were examined for cmv, b19v, and hsv-1/2 dna using real-time quantitative polymerase chain reaction (r ... | 2015 | 25976377 |
| large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation. | viral reactivations following hematopoietic stem cell transplantation are thought to result from the breakdown of both cell-mediated and humoral immunity. as a result, many viruses could be reactivated individually or simultaneously. using a multiplex polymerase chain reaction (pcr), we prospectively examined many kinds of viral dnas at a time in 105 patients who underwent allogeneic hematopoietic stem cell transplantation. in total, 591 whole blood samples were collected weekly from pre- to 42 ... | 2015 | 25946433 |
| nationwide survey of mother-to-child infections in japan. | the aim of this survey study was to evaluate a state of mother-to-child infections in japan. | 2015 | 25435331 |
| acute parvovirus b19 infection in identical twins unmasking previously unidentified hereditary spherocytosis. | identical caucasian male twins, previously fit, presented 1 week apart with short histories of fever and lethargy. the twins were febrile at presentation with profound pancytopaenia and evidence of haemolysis. there was no rash or arthralgia. both required multiple red cell transfusions. the twins had positive igm serology for epstein-barr virus (ebv), cytomegalovirus (cmv) and parvovirus b19. ebv viral capsid antigen and epstein-barr nuclear antigen iggs were also positive however, suggesting p ... | 2014 | 25073523 |
| [viral infections in pregnancy bearing a risk for the child]. | specific viral infections during pregnancy can be transmitted to the fetus or newborn. infections transmitted to the fetus during pregnancy are called prenatal or congenital infections, whereas infections passed from mother to child during delivery or in the first weeks after birth are called perinatal or neonatal infections. vertical transmission risk depends on the virus, maternal immunity against this virus and gestational age. interpretation of microbiological diagnostics for possible intrau ... | 2014 | 24988160 |
| infections and systemic lupus erythematosus. | systemic lupus erythematosus (sle) is a chronic autoimmune disease that presents a protean spectrum of clinical manifestations, and may affect any organ. the typical course of sle is insidious, slow, and progressive, with potential exacerbations and remissions, and even dramatically acute and rapidly fatal outcomes. recently, infections have been shown to be highly associated with the onset and/or exacerbations of sle, and their possible causative and/or protective role has been largely emphasiz ... | 2014 | 24715155 |
| analytical characterization of an assay designed to detect and identify diverse agents of disseminated viral infection. | diverse viruses often reactivate in or infect cancer patients, patients with immunocompromising infections or genetic conditions, and transplant recipients undergoing immunosuppressive therapy. these infections can disseminate, leading to death, transplant rejection, and other severe outcomes. | 2014 | 24440177 |
| detection and identification of viral pathogens in patients with hand, foot, and mouth disease by multilocus pcr, reverse-transcription pcr and electrospray ionization mass spectrometry. | rapid detection and identification of viruses are important for early diagnosis and effective surveillance of hand, foot, and mouth disease (hfmd). we described a novel assay using multilocus pcr and reverse transcription-pcr coupled with electrospray ionization mass spectrometry (rt-pcr/esi-ms) to simultaneously detect and identify human enterovirus a-d, adenovirus a-f, human herpesvirus 1-8, parvovirus b19 and polyomavirus. | 2014 | 24365476 |
| nationwide survey of maternal screening for mother-to-child infections in japan. | mother-to-child infections cause congenital infection with disease and sequelae. to evaluate a state of maternal blood screening for mother-to-child infections in japan, we for the first time conducted a nationwide survey on obstetric facilities where regular maternity checkups were carried out. a questionnaire assessment involved an annual number of deliveries, scale of facilities and a state of maternal blood screening for eight pathogens. a high rate (73.7%) of reply to the questionnaire was ... | 2014 | 24330048 |
| susceptibility to cytomegalovirus, parvovirus b19 and age-dependent differences in levels of rubella antibodies among pregnant women. | infections caused by cytomegalovirus (cmv), parvovirus b19 (b19), and rubella can lead to serious complications in pregnant women. the aim of this study was to determine the susceptibility to cmv, b19, and rubella antibodies in pregnant women in norway. consecutive sera samples were collected from pregnant women in two different regions in norway. sera were collected from age groups; ≤19, 20-24, 25-29, 30-34, 35-39, and ≥40 years old. of the 2,000 pregnant women tested, anti-cmv igg was positive ... | 2014 | 24114849 |
| broad-range pcr-electrospray ionization mass spectrometry for detection and typing of adenovirus and other opportunistic viruses in stem cell transplant patients. | hematopoietic stem cell transplant patients are highly susceptible to viral infections. follow-up after transplantation includes weekly screening using single, virus-specific real-time pcr tests, mainly for viruses in the families herpesviridae and adenoviridae that contribute to a high morbidity, especially in pediatric populations. the abbott plex-id platform combines broad-range pcr with electrospray ionization mass spectrometry to enable the simultaneous detection of multiple pathogens in a ... | 2013 | 24108617 |
| anti-trypanosoma cruzi cross-reactive antibodies detected at high rate in non-exposed individuals living in non-endemic regions: seroprevalence and association to other viral serologies. | cross-reactive antibodies are characterized by their recognition of antigens that are different from the trigger immunogen. this happens when the similarity between two different antigenic determinants becomes adequate enough to enable a specific binding with such cross-reactive antibodies. in the present manuscript, we report the presence, at an "abnormal" high frequency, of antibodies in blood samples from french human subjects cross-reacting with a synthetic-peptide antigen derived from a try ... | 2013 | 24069315 |
| serology indicates cytomegalovirus infection is associated with varicella-zoster virus reactivation. | varicella-zoster virus (vzv) causes chickenpox after which the virus remains latent in neural ganglia. subsequent reactivation episodes occur, leading mainly to subclinical detection of vzv, but also to the clinical entity herpes zoster. these reactivations are known to occur most frequently amongst immunocompromised individuals, but the incidence of herpes zoster is also known to increase with age, supposedly as a consequence of immunosenescence. our analysis aims to explore associations betwee ... | 2014 | 24037981 |
| selective reactivation of human herpesvirus 6 in patients with autoimmune connective tissue diseases. | viral infections have been associated with autoimmune connective tissue diseases. to evaluate whether active infection by epstein-barr virus (ebv), cytomegalovirus (cmv), human herpesvirus (hhv)-6, -7, -8, as well as parvovirus b19 (b19v) occur in patients with autoimmune connective tissue diseases, viral dna loads were assessed in paired samples of serum and peripheral blood mononuclear cells (pbmcs) of 115 patients affected by different disorders, including systemic sclerosis, systemic, and di ... | 2013 | 23983182 |
| the effects of age and viral serology on γδ t-cell numbers and exercise responsiveness in humans. | γδ t-cells are cytotoxic effector cells that preferentially migrate to peripheral tissues and recognize many types of antigen. we examined the effects of age and viral serology on the exercise responsiveness of γδ t-cells. blood was collected from 17 younger (age: 23-35yrs) and 17 older (50-64yrs) healthy males matched for cytomegalovirus (cmv), epstein-barr virus, herpes simplex virus-1 and parvovirus b19 serologic status before and after a single bout of cycling exercise. older had lower numbe ... | 2013 | 23954795 |
| human parvovirus b19 associated dilated cardiomyopathy. | we describe two children presenting with acute left ventricular dysfunction. both cases had evidence of dilated cardiomyopathy, requiring inotropic support and were tested for cardiotropic viruses by conventional or real-time polymerase chain reaction using specific primers for enteroviruses, human parvovirus b19, adenoviruses, epstein-barr virus (ebv), herpes simplex viruses 1 and 2 (hsv), human herpes virus-6 (hhv-6) and cytomegalovirus (cmv). igg and igm antibodies against parvovirus b19, ebv ... | 2013 | 23917364 |
| absence of viruses in amniotic fluid of women with pprom: a case series. | preterm premature rupture of membranes (pprom) and preterm birth are strongly linked to intrauterine inflammation. bacterial infection is often not identified as the cause. the objective was to examine the amniotic fluid of women with pprom for viral genomic content, and to correlate with the presence of bacterial infection and markers of intrauterine inflammation. a case series of 13 women with pprom is presented. amniocentesis was performed in each of these women. dna/rna isolated from amnioti ... | 2012 | 23021256 |
| [seroprevalence of antibodies against infectious pathogens relevant to pregnancy among healthcare workers]. | healthcare workers (hcws) are exposed to infectious diseases throughout the course of their work. the concerns of pregnant hcws are considerable because certain otherwise mild infections may affect fetal development. we studied 424 pregnant hcws at the university hospital frankfurt between march 2007 and july 2011. serological tests were carried out for varicella zoster virus (vzv), measles, mumps, rubella (mmr), cytomegalovirus (cmv) and parvovirus b19. our overall seroprevalence data with rega ... | 2012 | 22842885 |
| viral markers in patients with hemophagocytosis: a prospective study in a tertiary care hospital. | hemophagocytic syndrome (hps) is a rare clinicopathological condition characterized by the activation of macrophages with prominent hemophagocytosis in bone marrow and other reticulo-endothelial systems. hps can be familial or secondary to infections including viruses. | 2015 | 22771647 |
| increased seroprevalence of igg-class antibodies against cytomegalovirus, parvovirus b19, and varicella-zoster virus in women working in child day care. | primary maternal infection with cytomegalovirus (cmv), parvovirus b19 (b19v), and varicella-zoster virus (vzv) may result in adverse pregnancy outcomes like congenital infection or foetal loss. women working in child day care have an increased exposure to cmv, b19v, and vzv. by comparing the seroprevalence of igg-class antibodies against cmv, vzv and b19v in female day care workers (dcw) with the seroprevalence in women not working in day care this study aimed to assess the association between o ... | 2012 | 22726391 |
| cytomegalovirus and epstein-barr virus may be associated with some cases of cerebral palsy. | intrauterine infection is a risk factor for cerebral palsy. previous work reported a high frequency of viral dna in newborn screening cards from cerebral palsy cases and controls possibly due to contamination. | 2012 | 22372783 |
| seroprevalence of parvovirus b19, cytomegalovirus, hepatitis a virus and hepatitis e virus antibodies in haemophiliacs treated exclusively with clotting-factor concentrates considered safe against human immunodeficiency and hepatitis c viruses. | clotting-factor concentrates (cfc) are a potential source of transmission of blood-borne viruses. newer physical and chemical methods (pasteurization, wet-heating, solvent/detergent treating) developed to inactivate viruses are effective against hiv, hbv and hcv. however, it is not clear if these methods protect against other pathogenic viruses such as parvovirus b19, cytomegalovirus (cmv), hepatitis a virus (hav) and hepatitis e virus (hev). to evaluate the safety of current cfc we have studied ... | 1995 | 27214319 |
| the plasma virome of febrile adult kenyans shows frequent parvovirus b19 infections and a novel arbovirus (kadipiro virus). | viral nucleic acids present in the plasma of 498 kenyan adults with unexplained fever were characterized by metagenomics analysis of 51 sample pools. the highest to lowest fraction of plasma pools was positive for parvovirus b19 (75 %), pegivirus c (gbv-c) (67 %), alpha anellovirus (59 %), gamma anellovirus (55 %), beta anellovirus (41 %), dengue virus genotype 2 (denv-2) (16 %), human immunodeficiency virus type 1 (6 %), human herpesvirus 6 (6 %), hbv (4 %), rotavirus (4 %), hepatitis b virus ( ... | 2016 | 27902331 |
| profile of circulating levels of il-1ra, cxcl10/ip-10, ccl4/mip-1β and ccl2/mcp-1 in dengue fever and parvovirosis. | dengue virus (denv) and parvovirus b19 (b19v) infections are acute exanthematic febrile illnesses that are not easily differentiated on clinical grounds and affect the paediatric population. patients with these acute exanthematic diseases were studied. fever was more frequent in denv than in b19v-infected patients. arthritis/arthralgias with denv infection were shown to be significantly more frequent in adults than in children. the circulating levels of interleukin (il)-1 receptor antagonist (ra ... | 2012 | 22310535 |
| the vp1u receptor restricts parvovirus b19 uptake to permissive erythroid cells. | parvovirus b19 (b19v) is a small non-enveloped virus and known as the causative agent for the mild childhood disease erythema infectiosum. b19v has an extraordinary narrow tissue tropism, showing only productive infection in erythroid precursor cells in the bone marrow. we recently found that the viral protein 1 unique region (vp1u) contains an n-terminal receptor-binding domain (rbd), which mediates the uptake of the virus into cells of the erythroid lineage. to further investigate the role of ... | 2016 | 27690083 |
| viral-associated gn: hepatitis b and other viral infections. | by definition, viral-associated gn indicates the direct pathogenic relationship between active viral replication and the development of acute gn. this definition is in sharp contrast to the semantic label and pathophysiologic foundation behind postinfectious gn that uniquely develops only during a period of resolved and absent active infection. the primary example of postinfectious gn are the glomerular lesions described after a pharyngeal or cutaneous streptococcal infection and do not represen ... | 2016 | 27797900 |
| infection-related focal segmental glomerulosclerosis in children. | focal segmental glomerulosclerosis (fsgs) is the most common cause of steroid resistant nephrotic syndrome in children. it describes a unique histological picture of glomerular damage resulting from several causes. in the majority of patients the causing agent is still unknown, but in some cases viral association is evident. in adults, the most established fsgs causing virus is the human immune-deficiency virus, which is related to a collapsing variant of fsgs. nevertheless, other viruses are al ... | 2016 | 27294131 |
| non hcv-related infectious cryoglobulinemia vasculitis: results from the french nationwide cryovas survey and systematic review of the literature. | in patients with infectious cryoglobulinemia vasculitis (cryovas) in the absence of hepatitis c virus infection, data on presentation, therapeutic management and outcome are lacking. we conducted a nationwide survey that included patients with hcv-negative cryovas. we describe here the presentation, therapeutic management and outcome of 18 patients with non-hcv infectious cryovas and 27 additional patients identified form a systematic review of the literature. we included 18 patients, mean age 5 ... | 2015 | 26320984 |
| [cryoglobulinemia in a tunisian internal medicine department]. | cryoglobulinemia is characterized by multiple organ involvement, mainly including the skin, liver, kidneys, and peripheral nerves. our aim was to investigate the demographic, clinical, and serologic features, as well as survival in a group of 16 tunisian patients with cryoglobulinemia. | 2016 | 26039888 |
| torch infections. | torch infections classically comprise toxoplasmosis, treponema pallidum, rubella, cytomegalovirus, herpesvirus, hepatitis viruses, human immunodeficiency virus, and other infections, such as varicella, parvovirus b19, and enteroviruses. the epidemiology of these infections varies; in low-income and middle-income countries, torch infections are major contributors to prenatal, perinatal, and postnatal morbidity and mortality. evidence of infection may be seen at birth, in infancy, or years later. ... | 2015 | 25677998 |
| scalpel blade changer. | surgical knife has been extensively used in surgery for a number of years and is the most widely used surgical instrument in the world at present. manual removal of the blade can be difficult, particularly when the scalpel is wet. percutaneous injuries during changing the scalpel blade may lead to serious and potentially fatal infections from blood borne pathogens such as hepatitis b virus (hbv), hepatitis c (hcv), or human immunodeficiency virus (hiv) and others including cytomegalovirus, herpe ... | 2014 | 25491617 |
| viral infections in pregnancy: advice for healthcare workers. | healthcare workers (hcws) have the potential for increased exposure to infectious disease resulting from the provision of patient care. pregnancy can confer specific problems in some infections for the mother and her unborn child. | 2014 | 24767811 |
| pathogen safety of beriate®. | plasma-derived factor viii (fviii) concentrates have been used successfully to treat haemophilia a since the late 1960s. to ensure the pathogen safety of the plasma-derived fviii concentrate, beriate(®) (formerly beriate(®) p), donors of blood/plasma are carefully selected and all donations are screened for hepatitis b virus surface antigen (hbsag), antibodies against hiv types 1 and 2 (hiv-1/hiv-2) and hepatitis c virus (hcv), and genomic material of hepatitis a virus (hav), hepatitis b virus ( ... | 2014 | 24726555 |
| degenerate polymerase chain reaction strategy with dna microarray for detection of multiple and various subtypes of virus during blood screening. | the risk of transferring blood-borne infections during transfusion is continually increasing because of newly emerging and reemerging viruses. development of a rapid screening method for emerging viruses that might be transmitted by transfusion is required to eliminate such pathogens during blood donor screening. owing to increased use of human materials in organ transplants and cell therapy, the risk of donor-transmitted viral infections is also increasing. although nucleic acid amplification t ... | 2013 | 23590180 |
| the molecular prevalence of viral infections in transplant candidates with bone marrow suppression, shiraz, southern iran, 2010. | transient bone marrow suppression, characterized by acute inability of the bone marrow to produce circulating blood cells, may strongly relate to the pathogenesis of some viral infections. | 2013 | 25013658 |
| treatment of severe post-traumatic bone defects with autologous stem cells loaded on allogeneic scaffolds. | mesenchymal stem cells may differentiate into angiogenic and osteoprogenitor cells. the effectiveness of autologous pluripotent mesenchymal cells for treating bone defects has not been investigated in humans. we present a case series to evaluate the rationale of using nucleated cells from autologous bone marrow aspirates in the treatment of severe bone defects that failed to respond to traditional treatments. ten adult patients (mean age, 49.6-years-old) with severe bone defects were included in ... | 2012 | 23065806 |
| no evidence of presence of parvovirus 4 in a swedish cohort of severely immunocompromised children and adults. | the recently discovered human parvovirus 4 (parv4) has been associated with seropositivity for human immunodeficiency virus, hepatitis b virus and hepatitis c virus. high prevalence is seen especially in intravenous drug users. the virus has been detected in blood products and persons who have been repeatedly transfused have shown to be a risk-group. furthermore, reports from different parts of the world suggesting a prevalence ranging from zero to one third of the healthy population and the vir ... | 2012 | 23050026 |
| rituximab-based treatment, hcv replication, and hepatic flares. | rituximab, a chimeric mouse-human monoclonal antibody directed to the cd20 antigen expressed on pre-b lymphocytes and mature lymphocytes, causes a profound b-cell depletion. due to its peculiar characteristics, this drug has been used to treat oncohaematological diseases, b cell-related autoimmune diseases, rheumatoid arthritis, and, more recently, hcv-associated mixed cryoglobulinaemic vasculitis. rituximab-based treatment, however, may induce an increased replication of several viruses such as ... | 2012 | 22919406 |
| high prevelance of human parvovirus infection in patients with malignant tumors. | it is well known that the immunity of patients with malignant tumors decreases significantly. an increased parvovirus b19 (b19) infection rate has been observed in immunocompromised hosts. however, only a small amount of literature regarding the risk of human parvovirus infection in patients with malignant tumors is available. to evaluate the correlation of human parvovirus infection with malignant tumors, 288 serum samples from patients with malignant tumors were screened for b19 dna by nested- ... | 2012 | 22740966 |
| incidence of positive dna from cytomegalovirus, human parvovirus b19 and hepatitis b virus, at birth. | | 2012 | 22535167 |
| case report: risk of virus infection after accidental blood inoculation from a multi-infected aids patient. | infections caused by blood-borne viruses such as hepatitis b and c and the human immunodeficiency virus (hiv) are associated commonly with needlestick injuries, especially in a hospital setting. a prospective investigation was conducted on a medical doctor who suffered an accidental needlestick injury during blood collection from a patient with aids. the patient's blood contained 195,000 copies of hiv rna, 1 × 10(6) iu hepatitis c virus (hcv) rna, and >10(7) copies of parvovirus b19 dna per 1 ml ... | 2012 | 22499012 |
| environmental issues in thyroid diseases. | environmental factors are determinant for the appearance of autoimmune thyroid diseases (aitd) in susceptible subjects. increased iodine intake, selenium, and vitamin d deficiency, exposure to radiation, from nuclear fallout or due to medical radiation, are environmental factors increasing aitd. cigarette smoking is associated with graves' disease and graves' ophthalmopathy, while it decreases the risk of hypothyroidism and thyroid autoimmunity. viral infections are important environmental facto ... | 2017 | 28373861 |
| the blood dna virome in 8,000 humans. | the characterization of the blood virome is important for the safety of blood-derived transfusion products, and for the identification of emerging pathogens. we explored non-human sequence data from whole-genome sequencing of blood from 8,240 individuals, none of whom were ascertained for any infectious disease. viral sequences were extracted from the pool of sequence reads that did not map to the human reference genome. analyses sifted through close to 1 petabyte of sequence data and performed ... | 2017 | 28328962 |
| the role of human parvovirus b19 and hepatitis c virus in the development of thyroid disorders. | the presence of viruses in the thyroid has been shown, but whether they are implicated in thyroid diseases or are only spectators is under investigation. the most important candidate viruses for autoimmune thyroid disorders (aitd) are hepatitis c virus (hcv) and human parvovirus b19 (or erythrovirus b19 or evb19). retrospective and prospective case-control studies conducted on pathology slides showed (by pcr, in situ hybridization or immunohistochemistry) evb19 was present in thyroid tissues of ... | 2016 | 27220938 |
| myocardial and microvascular inflammation/infection in patients with hiv-associated pulmonary artery hypertension. | right ventricle compromise affects survival of patients with hiv-associated pulmonary artery hypertension (pah). | 2014 | 25144217 |
| human endogenous retrovirus w activity in cartilage of osteoarthritis patients. | the etiology of viruses in osteoarthritis remains controversial because the prevalence of viral nucleic acid sequences in peripheral blood or synovial fluid from osteoarthritis patients and that in healthy control subjects are similar. until now the presence of virus has not been analyzed in cartilage. we screened cartilage and chondrocytes from advanced and non-/early osteoarthritis patients for parvovirus b19, herpes simplex virus-1, epstein barr virus, cytomegalovirus, human herpes virus-6, h ... | 2014 | 25136615 |
| association of interferon gamma gene polymorphisms with bk virus infection among hispanic renal allograft recipients. | bk virus nephropathy is one of the most common viral infections that affect up to 10% of renal transplant recipients (rtrs), causing allograft dysfunction and graft loss. interferon-gamma (ifn-γ) gene polymorphisms have been associated with parvovirus b19, hepatitis c virus, hiv-1/aids infection, cytomegalovirus viremia, and disease. ifn-γ is known to have potent inhibitory effects on bk virus gene expression, both at the level of transcription and translation. | 2014 | 24642663 |
| evaluation of two, commercial, multi-dye, nucleic acid amplification technology tests, for hbv/hcv/hiv-1/hiv-2 and b19v/hav, for screening blood and plasma for further manufacture. | the cobas taqscreen mpx test, version 2.0, a multiplex, multi-dye nucleic acid amplification technology (nat) test from roche was evaluated by two european blood banks, the german red cross blood donor service, frankfurt, germany and centro de hemoterapia y hemodonación de castilla y león, valladolid, spain. in addition, the cobas taqscreen dpx test was evaluated for the simultaneous detection and quantitation of parvovirus b19 and the detection of hepatitis a virus (hav). | 2013 | 23252689 |
| parvovirus transmission by blood products - a cause for concern? | the introduction of dual viral inactivation of clotting factor concentrates has practically eliminated infections by viruses associated with significant pathogenicity over the last 20 years. despite this, theoretical concerns about transmission of infection have remained, as it is known that currently available viral inactivation methods are unable to eliminate parvovirus b19 or prions from these products. recently, concern has been raised following the identification of the new parvoviruses, hu ... | 2012 | 23025427 |
| high prevalence of human parvovirus 4 infection in hbv and hcv infected individuals in shanghai. | human parvovirus 4 (parv4) has been detected in blood and diverse tissues samples from hiv/aids patients who are injecting drug users. although b19 virus, the best characterized human parvovirus, has been shown to co-infect patients with hepatitis b or hepatitis c virus (hbv, hcv) infection, the association of parv4 with hbv or hcv infections is still unknown.the aim of this study was to characterise the association of viruses belonging to parv4 genotype 1 and 2 with chronic hbv and hcv infectio ... | 2012 | 22235298 |
| cynomolgus monkeys (macaca fascicularis) experimentally infected with b19v and hepatitis a virus: no evidence of the co-infection as a cause of acute liver failure. | this study was conducted to analyse the course and the outcome of the liver disease in the co-infected animals in order to evaluate a possible synergic effect of human parvovirus b19 (b19v) and hepatitis a virus (hav) co-infection. nine adult cynomolgus monkeys were inoculated with serum obtained from a fatal case of b19v infection and/or a faecal suspension of acute hav. the presence of specific antibodies to hav and b19v, liver enzyme levels, viraemia, haematological changes, and necroinflamma ... | 2016 | 27074255 |
| the prevalence of hepatitis a virus and parvovirus b19 in source-plasma donors and whole blood donors in china. | to compare the prevalence of hepatitis a virus (hav) and human parvovirus b19 (b19v) between source-plasma (sp) donors and whole blood (wb) donors. | 2015 | 26564017 |
| validation of new real-time polymerase chain reaction assays for detection of hepatitis a virus rna and parvovirus b19 dna. | to meet european guidelines for plasma for fractionation, plasma fractionators have implemented parvovirus b19 (b19v) and hepatitis a virus (hav) nucleic acid test (nat) screening on test pools. in this study we evaluate recently developed in-house nat assays for b19v dna and hav rna. the b19v nat was designed to target two different regions of the b19v genome. | 2016 | 26354230 |