| effects of type a botulinum toxin on the cholinergic transmission at spinal renshaw cells and on the inhibitory action at ia inhibitory interneurones. | 1. the central action of botulinum toxin a (bta) on the cholinergic transmission at renshaw cells (rcs) and on the rc-induced inhibition of ia inhibitory interneurones (iains) was studied in anaesthetized cats. bta was administered by application directly into the spinal cord, injection into a ventral root (l7) and/or injection into the triceps surae (gs) muscle. 2. a direct application of bta into the spinal cord led to a decrease of the early and the late response of rcs. 3. when the neurotoxi ... | 1977 | 200852 |
| neuronal mechanisms influencing transmission in the baroreceptor reflex arc. | | 1977 | 200971 |
| regions of cerebral ischemia located by pyridine nucleotide fluorescence. | the fluorescence of the reduced form of the endogenous pyridine nucleotide nicotinamide adenine dinucleotide was used to map regions of ischemia in cat brain. a remarkably microheterogeneous pattern of increased fluorescence resulted from a critical level of incomplete cerebral ischemia. the fluorescence pattern suggests that ischemia occurs initially in microwatershed zones between penetrating cerebral arteries. | 1977 | 201026 |
| [physiology of the pallidum (globus pallidus)]. | | 1977 | 201121 |
| l-dopa-induced hypotension: depression of spinal sympathetic neurons by release of 5-hydroxytryptamine. | in studies designed to determine the respective functional roles of two bulbospinal monoaminergic pathways to sympathetic preganglionic neurons, both l-dopa and precursors of 5-ht depressed transmission through excitatory spinal reflex and bulbospinal sympathetic pathways. transmission through spinal reflex pathways was secondarily enhanced after l-dopa. pharmacological tests indicated mediation of these affects by monoamines. after antagonism or depletion of central 5-ht, l-dopa only enhanced t ... | 1977 | 201160 |
| antinociceptive effect of dopaminergic neurotransmission evoked by mesencephalic stimulation on spinal interneuronal activity in cats. | | 1977 | 201161 |
| studies of naturally transmitted feline leukemia virus infection. | | 1977 | 201187 |
| herpesvirus-induced urolithiasis in specific-pathogen-free male cats. | | 1977 | 201200 |
| reversible blockade of pgo waves and concomitant modifications of thalamic unit activity in chronic cats. | the reversible blockade of geniculate pgo waves was carried out by localized cooling of the ponto-geniculate pathways during paradoxical sleep in chronic cats. in parallel, long-term recordings of unit activity were performed in non-specific visuooculomotor thalamic structures where no pgo waves occurred. blockade of geniculate pgo waves is concomitant with a preferential modification of the phasic discharge of the unit activity (i.e. time-locked with rapid eye movements) when compared to the to ... | 1977 | 201340 |
| substance p selectively blocks nicotinic receptors on renshaw cells: a possible synaptic inhibitory mechanism. | | 1977 | 201343 |
| evidence that 5-ht is not the afferent transmitter in the cochlea. | | 1977 | 201481 |
| amino acids - putative afferent transmitter in the cochlea? | | 1977 | 201482 |
| electrophysiological studies of the septal nuclei. ii. the medial septal region. | | 1978 | 201483 |
| proposed effects of brain noradrenaline on neuronal activity and cerebral blood flow during rem sleep. | we propose that the observed increases of both neuronal activity and cerebral blood flow seen throughout the brain during rem sleep may be effects of decreased central noradrenaline release. | 1977 | 201486 |
| the influence of dihydroergotoxine mesylate on the low-km phosphodiesterase of cat and rat brain in vitro. | dihydroergotoxine mesylate (dhet; active substance of hydergine) was shown to be a stronger inhibitor of the low-km than of the high-km phosphodiestrase (pe) in cat and rat brain homogenates. the inhibition due to dhet was greater when a purified low-km pe preparation originating from a sonicated pellet (100,000 g) of rat brain tissue was used. the drug alters the kinetic properties of the enzyme, producing a lowering of the negative cooperativity effect. this kind of pe inhibition is of particu ... | 1978 | 201542 |
| reiteration frequency of feline type c viral genomes in homologous and heterologous host cell dna. | differences in the multiplicity of proviral sequences of two feline endogenous viruses, rd-114 and felv, in homologous and heterologous host dna were examined by viral cdna hybridization using cellular dna fractionated with respect to reiteration frequency. the endogenous proviral dnas in cat cells were fractionated predominantly with intermediate-repeated sequences, while rd-114 proviral dna in virus-infected human cells was fractionated together with unique-sequence dna. these differences were ... | 1978 | 201591 |
| reflectance spectrophotometry of cytochrome aa3 in vivo. | | 1977 | 201603 |
| oxidation of cerebral cytochrome aa3 by oxygen plus carbon dioxide at hyperbaric pressures. | the reduction-oxidation level of cytochrome aa3 in the intact cerebral cortex of cerveau isolé or pentobarbital-anesthetized cats was monitored by means of dual-beam reflectance spectrophotometry. respiratory gases containing varying fractions of carbon dioxide and oxygen were administered at increased pressures, allowing titration of the cytochrome redox state from maximum reduction during nitrogen ventilation to the completely oxidized state. we show that the fully oxidized state could be reac ... | 1977 | 201604 |
| mechanisms contributing to malignant dysrhythmias induced by ischemia in the cat. | continuously recorded bipolar electrograms were obtained simultaneously from epi-, endo-, and mid-myocardial regions of the ischemic and normal zones of cat left ventricle in vivo after coronary occlusion, analyzed by computer, and compared to regional cyclic amp levels. regional cyclic amp content was used as an index of the combined local effects of: (a) efferent sympathetic nerve discharge; (b) release of myocardial catecholamines due to ischemia; and (c) circulating catecholamines. ischemia ... | 1978 | 201667 |
| a mixed mesodermal tumour in the uterus of a cat. | | 1977 | 201678 |
| the effect of pancuronium and gallamine on muscarinic transmission in the superior cervical ganglion. | pancuronium enhanced contraction of the nictitating membrane elicited via ganglionic muscarinic pathways in the superior cervical ganglion of the cat. in order to elucidate this phenomenon, recordings of the superior cervical ganglion surface potential were made which demonstrated that pancuronium and gallamine reduced and haloperidol enhanced ganglionic hyperpolarization without significantly altering the ganglionic slow depolarization. pancuronium reversed the effects produced by haloperidol, ... | 1978 | 201745 |
| substance p and renshaw cells: a new concept of inhibitory synaptic interactions. | 1. the actions of microelectrophoretically administered substance p on renshaw cells in pentobarbitone anaesthetized cats were investigated. 2. the effects on spontaneous and synaptic firing and interactions with a number of other agents including acetylcholine, acetyl-beta-methylcholine, acidic amino acids, morphine, dihydro-beta-erythroidine and strychnine were studied in attempts to elucidate the mechanism of action of substance p. 3. substance p usually selectively depressed the excitation b ... | 1977 | 201746 |
| regulation of steroidogenesis and prostaglandin formation in isolated adrenocortical cells: the effects of pregnenolone and cycloheximide. | | 1977 | 201802 |
| excretion of feline leukaemia virus by naturally infected pet cats. | | 1977 | 201852 |
| a feline leukaemia virus- and sarcoma virus-induced tumour-specific antigen. | | 1977 | 201856 |
| [epsp's of the motor neurons of cat masticatory muscles induced by stimulation of low-threshold infraorbital nerve fibers]. | the effects of the infraorbital aalpha afferents stimulation on the masseter motoneurons were investigated in cats under chloralose-nembutal anesthesia. it is found that stimuli 1.4-2.5 times threshold (t) evoke complex epsps in 69% of the investigated motoneurons, their latency being 2.1 +/- 0.2 ms (1.5-3.0 ms, n = 36), amplitude up to 30 mv and duration 9-15 ms. these epsps consist of two simpler responses produced by activation of two separate groups of afferent fibres. the short-latent epsps ... | 1977 | 201873 |
| vestibular and somatosensory interaction in the cat vestibular nuclei. | the vestibular nuclei of cats were explored extracellulary with micropipettes to locate units with a resting discharge rate which responded to rotation in the horizontal plane. these units were examined for somatosensory input from neck and limbs. fewer than half responded to somatosensory stimulation. the neck region was the body area most effective in influencing unitary activity. the response pattern most often noted was an increase and decrease in discharge frequency when the body was moved ... | 1977 | 201917 |
| study into the mechanism of acetylsalicylic acid-induced bronchoconstriction. | in order to elucidate the mechanism of the acetylsalicylic acid-induced bronchoconstrictor responses which have been observed in asthmatic patients, experiments were done in cats, anesthetized by chloralose, vagotomized, and completely relaxed by infusion of suxamethonium. in about half of the experiments, the sensitivity of the bronchi to 5-hydroxytryptamine (5-ht) was considerably enhanced after the administration of 5--6 mg/kg acetylsalicylic acid, a dose which had previously been shown to su ... | 1977 | 201944 |
| influence of structural changes in the imidazolidine ring of clonidine on hypotensive activity. | 2-(2,6-dichlorophenylimino)piperimidine with hno3 (st-404), 2-(2,6-dichlorophenyl)-5,6-dihydroimidazo[2,1-b]thiazole fumarate (compound 44-549) and 1,2,3,5-tetrahydroimidazo[2,1-b]quinazoline with hcl (tiq) were studied with respect to their effects on blood pressure and heart rate in the anaesthetized, normotensive rat following intravenous administration and in the chloralose-anaesthetized cat by means of infusions via the left vertebral artery. st-404 and compound 44-549 possess central hypot ... | 1978 | 201948 |
| [effect of vincamine on sleep-wakefulness equilibrium in the cat (author's transl)]. | intra-muscular vincamine in the cat (chronic experimental preparation) causes a change in the equilibrium between sleep and wakefulness. this consists of: (1) an increase in the amount of wakefulness, the duration of which depends on the dose injected (5-10 mg/kg) and the mode of injection (more effective when given in two doses than all at once); (2) a decrease in slow wave sleep (sws) which often has the appearance of phasic slow wave sleep; (3) a transitory suppression of paradoxical sleep (p ... | 1977 | 201975 |
| [excessive 7-14-sec positive spikes during rem sleep in monozygotic non-epileptic twins with speech retardation (author's transl)]. | 6-14/sec positive spikes (ps) (in our cases 7-14) were observed during 6 all-night sleep, recordings in one pair of monozygotic twins (aged 7 years), who had severe speech retardation, no epilepsy and were otherwise normal (cat were normal). the eeg during wakefulness and sleep showed multifocal independent spikes over the left mid-temporal and right parieto-occipital area. the 7-14 ps, which were similar in both twins, occurred slightly during light sleep, were absent during slow sleep and were ... | 1977 | 201978 |
| [preliminary study of the comparative action of 1 methyl-2 (2 naphtyl) aziridine on kindling effect and on paradoxical sleep (author's transl)]. | methyl-2 (2 naphtyl) aziridine (mna) is a new agent which has been demonstrated to have effects on paradoxical sleep (ps) and on the levels of cerebral noradrenaline (yamamoto, 1975). it has been tried on a experimental model of epilepsy, the kindling effect, produced in the cat by repetitive stimulation of the amygdala. the results obtained in the cat confirmed blockage of paradoxical sleep (ps) and revealed a marked reduction in the number of stimuli required to produce the effect. the shorten ... | 1977 | 201979 |
| evidence for opposing influences of cyclic gmp and cyclic amp on force of contraction in mammalian myocardium. | the inotropic effects of the 8-br-derivatives of cyclic gmp and cyclic amp were investigated in guinea pig or rat auricles and papillary muscles from cats. in guinea pig auricles, 8-br-cyclic gmp had a concentration-dependent negative inotropic effect, whereas 8-br-cyclic amp had a concentration-dependent positive inotropic effect. a negative inotropic effect of 8-br-cyclic gmp in rat auricles was obtained with 30 times lower doses than in guinea pig auricles; the pacemaker activity of spontaneo ... | 1976 | 201992 |
| the inhibitory effect of coli-endotoxin on alpha-adrenergic receptor functions in the lower urinary tract. an in vitro study in cats. | the effects of endotoxin from e. coli 06 on alpha-adrenergic receptor functions have been investigated in muscle strips from the outlet region of the feline bladder. the endotoxin from this strain, known to cause urinary tract infections, inhibited the alpha-adrenergic contractions induced by phenylephrine and noradrenaline. this inhibition was dose-dependent, correlated to time of exposure, and reversible. alpha-adrenergic receptor function in muscle strips from cat aorta was also inhibited, bu ... | 1977 | 202017 |
| intracellular analysis of trigeminal motoneuron activity during sleep in the cat. | intracellular recordings were made from trigeminal motoneurons of normally respiring, unanesthetized cats during naturally occurring sleep. the transition from quiet to active sleep was accompanied by tonic motoneuron hyperpolarization. stimulation of the reticular formation induced a depolarizing potential in trigeminal motoneurons during quiet sleep and a hyperpolarizing potential during active sleep. the results provide a synaptic explanation for the phenomenon of reticular response reversal ... | 1978 | 202025 |
| grouping of patients with hyperparathyroidism by clinical signs, correlated to some biochemical findings. | serum parathormone (s-pth), total and free fractions of serum calcium (cat and caf), urinary excretion of cyclic 3',5'-adenosine monophosphate (campu), serum phosphate and serum magnesium were analysed in 68 patients with hyperparathyroidism verified by operation and pad. the diagnostic significance of the analyses was examined. it was shown that caf was consistently above normal even in patients in whom the other tests were normal. the best diagnostic sensitivity was thus found for caf followed ... | 1976 | 202128 |
| importance of cardiac and vascular beta-receptors in the action of phentolamine. | to determine to what extent the effects of phentolamine (phe) are mediated by the cardiac and vascular beta-receptors, the action of the drug was studied in anaesthetized cats pretreated with beta-blockers. blockade of the cardiac beta-receptors with either propranolol or metoprolol entirely prevented the increases in heart rate, dp/dt and cardiac output caused by phe. in animals pretreated with propranolol (in a dose blocking the vascular beta-receptors) or metoprolol (in a purely cardio-select ... | 1977 | 202150 |
| integration of afferent inputs from neck muscles and macular labyrinthine receptors within the lateral reticular nucleus. | | 1977 | 202210 |
| properties of aleutian disease virus assayed with feline kidney cells. | properties of aleutian disease virus (adv) were studied using feline kidney cells, line crfk, to assay virus by the induction of nuclear antigen. adv nuclear antigen was detected by immunofluorescent staining. titers of virus obtained from mink spleens at 10-8 days after infection were usually between 10(3) and 10(5) infectious units per gram of spleen. adv was purified by fluorocarbon extraction, differential centrifugation, biogel a-15 chromatography and cscl equilibrium centrifugation. the mo ... | 1977 | 202229 |
| microvessel reactions and nad-nadh changes in cat brain cortex during cortical stimulation under normo- and hypercapnic conditions. | | 1977 | 202240 |
| cerebrovascular and metabolic reactions at the cbf autoregulatory level evoked by electrical stimulation of the cat brain cortex. | | 1977 | 202242 |
| are increases in cyclic gmp levels responsible for the negative inotropic effects of acetylcholine in the heart? | | 1977 | 202278 |
| [effect of high temperature on the direct cortical response]. | acute experiments were conducted on anesthetized cats placed in a thermochamber at a temperature of 45 degrees c. the direct cortical response in suprasylvian convolution of the cortex during hyperthermia and after the restoration of the thermal homeostasis was studied. it was revealed that hyperthermia caused primary inhibition at a temperature of 40 degrees c and above it, and even complete disappearance of the slow negative potential; above 43 degrees c there was found a gradual depression of ... | 1977 | 202348 |
| relaxation of smooth muscle following contraction elicited by sympathetic nerve stimulation in vivo. | 1. a method for studying in vivo the process of neuroeffector transmission in the nictitating membrane and nasal blood vessels of the cat is described. 2. administration of desmethylimipramine or cocaine caused increases in both the amplitude and duration of the nasal and membrane responses which may be explained by inhibition of neuronal uptake of noradrenaline. 3. phenoxybenzamine depressed the responses to nerve stimulation, but had little effect on the relationship between response amplitude ... | 1977 | 202357 |
| functional organization of the spinal reflex pathways from forelimb afferents to hindlimb motoneurones in the cat. | | 1978 | 202374 |
| state of the art. sleep and control of breathing. | | 1978 | 202437 |
| laryngeal abductor activity during sleep. | | 1978 | 202438 |
| spinal branching of rubrospinal axons in the cat. | the branching patterns of rubrospinal (rs) axons projecting to the cervical spinal cord between c3 and c8 were studied in the cat. rs neurons were identified by their antidromic responses to microstimulation of local axon branches within the cervical gray matter. twenty-six of 58 rs neurons projecting to the cervical gray matter also sent axon branches to the thoracic spinal cord. two out of 40 of these rs neurons also sent axon branches to the lumbar spinal cord. using a collision technique, it ... | 1977 | 202474 |
| properties of the synaptic transmission of the newly formed cortico-rubral synapses after lesion of the nucleus interpositus of the cerebellum. | 1. properties of synaptic transmission during and after repetitive activation of the newly formed cortico-rubral were examined in the red nucleus neurons (rn) of cats after lesions of the nucleus interpositus of the cerebellum (chronic cats) as well as in normal ones. 2. a prominent facilitation of the amplitude of cortico-rubral unitary epsps was observed in both normal and chronic cats when a stimulus to the cerebral peduncle (cp) was preceded by another stimulus by 2-50 msec. 3. time course o ... | 1977 | 202475 |
| [local temperature characteristics of the isolated cortex in wakefulness and alteration of the sleep stages]. | in cats, changes of the brain electric activity were followed by local temperature shifts in isolated and in intact cortex: the transition from slow wave sleep to paradoxical sleep and from quiet to active wakefulness were accompanied by increasing of the cortex temperature, while transition from paradoxical sleep to slow sleep decreased the temperature. during falling asleep and alternation of the sleep stages, both in isolated and intact cortex, the temperature shifts preceded the electric act ... | 1977 | 202512 |
| [effect of acth and hydrocortisone on the functional state and interaction of brain structures]. | in chronic experiments on cats acth facilitated the development of behavioral responses to gradually increasing electric stimulation of the medial hypothalamus, hippocampus and the midbrain reticular formation as well as potentiated the reticulo-hypothalamic influence. the effect of hydrocortisone was opposite. the reciprocal reticular and hormonal influences on the basal and anterior amygdala were revealed as well as some hormonal changes due to unspecific thalamic effects upon the limbic struc ... | 1978 | 202514 |
| immuno-prophylaxis and -therapy of c-type oncorna viral diseases in mice and cats. | | 1977 | 202852 |
| feline oncornavirus-associated cell membrane antigen: evidence for an immunologically crossreactive feline sarcoma virus-coded protein. | the feline oncornavirus-associated cell membrane antigen (focma) acts as a target for natural immuno-surveillance against tumor development in the cat. in the present study, mink and rat cells nonproductively transformed by feline sarcoma virus (fesv) were shown to express focma as well as 5'-terminal feline leukemia virus (felv) gag gene proteins, p15 and p12. in contrast, such cells lack detectable levels of other felv gag gene-coded proteins or the env gene product, gp70. focma, p15, and p12 ... | 1977 | 202959 |
| an in vitro transformation assay for sisv-1 and hl23v using feline embryonic fibroblasts. | | 1978 | 202976 |
| gaba-receptors in the vertebrate nervous system. | | 1977 | 202995 |
| the locus coeruleus: neurobiology of a central noradrenergic nucleus. | | 1977 | 202996 |
| preliminary observations on the functional transmission to the internal anal sphincter (in vitro preparation) in six mammalian species [proceedings]. | | 1977 | 203120 |
| the phases of sleep and wakefulness after bilateral labyrinth destruction in chronic cats. | after bilateral destruction of the labyrinths, the duration of paradoxical sleep increased from 4% in the intact animals to 8% after destruction. this increase was the result of an increase from 2.2 to 2.6 in the average number of epiodes of paradoxical sleep as well as of an increase from 3.2 to 5.5 min of the duration of each episode of paradoxical sleep. one latency of the first appearance of an episode was shortened, from the 77th min at the beginning of registration to the 43rd min after de ... | 1976 | 203167 |
| the beta-adrenergic activity of some monosubstituted phenethanolamines. | a series of monosubstituted phenethanolamines with n-isopropyl and n-tert-butyl substituents has been prepared. a detailed pharmacological study has been made of the beta-adrenergic activity of these materials as the nitrogen substituent and the nature and position of the phenyl substituent were changed, and their selectivity has been determined for beta1- and beta2-adrenoceptors in guinea-pig and cat tissues. | 1977 | 203235 |
| [causes for species difference in acute toxicity of chlorocholine chloride]. | chlorocholine chloride (ccc) inhibits neuromuscular transduction of excitation and, consequently, leads to respiratory arrest in cases of acute intoxication. an account is given of the relationships between neuromuscularly blocking activity and acute toxicity of ccc. several animal species and pharmacological models are used to produce evidence to the effect that ccc-caused inhibition of neuromuscular transmission of excitation is characterised by parameters typical of block due to depolarisatio ... | 1977 | 203241 |
| some effects of the aminoglycoside antibiotic amikacin on neuromuscular and autonomic transmission. | the effects of the new aminoglycoside antibiotic amikacin on neurohumoral transmission were tested in the anaesthetized cat, and in mouse, rat and chick isolated nerve-muscle preparations. amikacin had blocking actions on both autonomic and neuromuscular transmission. the autonomic effects were caused mainly by ganglion blockade and were reversed by calcium. the amikacin-induced neuromuscular blockade reculted from a decreased release of acetylcholine and a reduced postjunctional sensitivity. in ... | 1978 | 203306 |
| [nociceptive afferent blockade by percutaneous peripheral stimulation in the cat]. | experiments have been performed in order to study the effects of percutaneous peripheral stimulation (pcps) both on the transmission of messages elicited by recruiting sensory units of the tooth pulp at the thalamic centrum medianum level and on the jaw opening reflex (jor). both evoked potentials and jor were inhibited by stimuli applied to the limbs by means of percutaneous (needle) electrodes. observed inhibitory effects were not immediate: there was a latency period and progressive induction ... | 1977 | 203371 |
| [the effect of nalorphine on analgesia induced by peripheral stimulation]. | the blockade of effects induced by percutaneous peripheral stimulation were abolished by injection of an opiate antagonist as nalorphine. our results lead to the hypothesis that central and peripheral stimulations act by the same mechanism in producing blockade of noxious impulses. one may suggest that peripheral stimulations induce release of endogenous morphine-like substances which in turn give descending inhibition. | 1977 | 203372 |
| bvr-1, a restriction locus of a type c rna virus in the feline cellular genome: pleiotropic restriction of endogenous balb virus in cat x mouse somatic cell hybrids. | bvr-1 is a dominant x-linked feline gene which restricts the replication of b-tropic murineleukemia virus (b-mulv) in somatic cell hybrids between murine balb/c-rag cells and fl-74 feline cells. since the hybrids were originally derived by the hypoxanthine aminopterin thymidine selection scheme, counter selection experiments on 6-thioguanine result in preferential survival of hybrid cells which have spontaneously lost the feline x-chromosome on which is located the structural gene for hypoxanthi ... | 1978 | 203649 |
| properties of a transforming virus, kimsv(rhhv), isolated from a co-culture of rat htc-h1 cells with k-nrk cells. | some morphological, biological, immunological and biochemical characterizations of a virus, rat helper virus pseudotype kirsten sarcoma virus, kimsv(rhhv), have been presented here. kimsv(rhhv) has a type c virus ultrastructure. it is strictly rat tropic and is able to transform rat cells in vitro. the possibility of its being a xenotropic mouse virus has been carefully ruled out by exhaustive analyses of host range and immunological studies. antigenically kimsv(rhhv) demonstrates cross reactivi ... | 1978 | 203653 |
| lysis of feline lymphoma cells by complement-dependent antibodies in feline leukemia virus contact cats. correlation of lysis and antibodies to feline oncornavirus-associated cell membrane antigen. | | 1978 | 203702 |
| oncornavirus lytic activity in the serum of gibbon apes. | fresh blood serum from normal gibbon apes (hylobates lar) contained heat-sensitive lytic activity for various mammalian oncornaviruses. lytic activity quantitatively similar to that in gibbon serum was demonstrated in serum from three other primate species, including man; it was demonstrated to be low or absent in lower mammalian species with the exception of domestic cats, which had intermediate levels of serum lytic activity. gibbons that acquired infectious gibbon ape leukemia virus, either n ... | 1978 | 203712 |
| [excitation and inhibition in the nervous system (author's transl)]. | | 1978 | 203874 |
| sleep induced by intestinal stimulation in cats. | the influence of afferent impulses of intestinal origin on the sleep stages was studied in fed and starved cats. low-frequency electrical stimulation of the mucosal surface in a small intestinal fistula reduced the latency of sleep onset. the number of slow wave sleep episodes decreased, but their mean duration increased during stimulation. conversely, the number of paradoxical sleep episodes increased, but their mean duration was not significantly modified by the intestinal stimulation. the rol ... | 1977 | 203959 |
| processing of sensory information. | | 1977 | 203982 |
| opiate receptors for behavioral analgesia resemble those related to the depression of spinal nociceptive neurons. | with naloxone as antagonist, a dose-ratio analysis of the depression by morphine of nociceptive neurons in the spinal cord reveals that this opiate depression of single unit activity has the same pharmacological properties as observed with morphine analgesia. this suggests that the opiate receptor, mediating the observed cellular depression, and those mediating analgesia are presumably the same. | 1978 | 204008 |
| [splenic lesions during benign inoculation lymphoreticulosis]. | the authors describe the fibro-granulomatous lesions with scar formation on a splenectomy specimen removed for familial spherocytosis, eight weeks after the onset of cat scratch disease. this original observation, apparently unique in the literature, is in favour of the blood spread of the agent responsible for benign inoculation lymphoreticulosis, and suggests a pathogenic theory for the unusual visceral manifestations. | 1977 | 204030 |
| noradrenaline evoked beta adrenergic dilatation of precapillary sphincters in skeletal muscle. | | 1978 | 204159 |
| observations on the natural history of encephalomyocarditis virus. | | 1978 | 204205 |
| in vitro antiviral efficacy of ribavirin against feline calicivirus, feline viral rhinotracheitis virus, and canine parainfluenza virus. | ribavirin had marked in vitro activity against feline calcivirus, strain 255, and canine parainfluenza virus, but showed only slight antiviral effect on feline viral rhinotracheitis virus. antiviral activity was manifested by partial to complete suppression of viral cytopathic effect and of viral replication, depending on concentration of ribavirin in the culture medium and dosage of viral inoculum. concentrations of ribavirin as small as 3.2 microgram/ml and 1.0 microgram/ml showed some activit ... | 1978 | 204229 |
| cyclic amp-induced enhancement of calcium accumulation by the sarcoplasmic reticulum with no modification of the sensitivity of the myofilaments to calcium in skinned fibres from a yeast skeletal muscle. | in the presence of low concentrations of total egta (5 . 10(-4) m) and free mg2+ (3.16 . 10(-5) m) and in the presence of caffeine (8 . 10(-3) m), cyclic amp (5 . 10(-6) m) produces a relaxation of the tension developed by skinned fibres from cat caudo-femoralis. the relaxation can be attributed to an enhancement of the ca2+ accumulation by the sarcoplasmic reticulum, since cyclic amp does not modify the sensitivity of the myofilaments of ca2+. these results are similar to those previously repor ... | 1978 | 204360 |
| a model of quick phase generation in the vestibuloocular reflex. | the vestibuloocular relfex of the cat was studied during step and sinusoidal head velocity stimuli. a model is presented which simulates the observed slow phase and quick phase behavior. the model is constructed to be compatible with neurophysiological observations of the behavior of neurons in the pons. emphasis is placed on the amplitude and timing of quick phases which are active orienting movements that drive the eyes into the direction of turning. it is proposed that quick phases, like sacc ... | 1978 | 204366 |
| effects of indomethacin on cholera toxin-induced cerebrospinal fluid production. | | 1978 | 204397 |
| cat leukemia and the cluster controversy. | | 1978 | 204405 |
| clinicopathological manifestations of selected neoplasms. | this report provides a general overview of the pathobiology of neoplasia, and an update on the clinicopathological manifestations of lymphosarcoma, mastocytoma, histiocytoma, melanoma, sarcoid and circumanal gland tumors in domestic animals. neoplasia represents a continuum of events from reversible hyperplasia to irreversible and pathological changes in tissue growth patterns. in some instances the causes of this disease process have been identified, but the etiology of the majority of naturall ... | 1978 | 204450 |
| recent developments in feline disease research. | | 1978 | 204451 |
| small animal geriatric and pediatric medicine. | | 1978 | 204453 |
| the frequency of occurrence of feline leukaemia virus subgroups in cats. | feline leukaemia viruses (felv) were isolated from cats in glasgow and new york with lymphosarcoma and from apparently healthy carrier cats. the subgroup composition of each isolate was determined. all isolates contained felv of subgroup a(felv-a) and a high proportion also contained subgroup b virus (felv-b). virus of subgroup c (felv-c) was rare and occurred in association with felv-a and, in some isolates, with felv-b as well. the same pattern was observed in isolates from british and america ... | 1978 | 204584 |
| position sensitivity of de-efferented muscle spindles in experimental acrylamide neuropathy. | an experimental neuropathy was induced in cats by injections of acrylamide (7.5, 15 or 30 mg/kg/day) for 2 to 10 days. the responses of primary and secondary endings of soleus muscle spindles to stretch were evaluated and correlated with the appearance of ataxia and incoordinated motor movements. animals that received 15 or 30 mg/kg/day became ataxic and demonstrated poor motor coordination on the 7th or 4th day, respectively. at these times, both primary and secondary endings of muscle spindles ... | 1978 | 204769 |
| involvement of nicotinic and muscarinic receptors in synaptic transmission in cat superior cervical ganglions reinnervated by vagal primary afferent axons. | artificial synapses were established in the superior cervical ganglion reinnervated by vagal afferent fibers by heterologous cross-anastomosis between the cranial end of nodose ganglion and the caudal end of superior cervical ganglion in cats. formation of functional synapses was evidenced by unilateral mydriasis and contraction of the nictitating membrane in response to inflation of the stomach with a balloon or to electrical stimulation of the afferent vagus. electron microscopic findings indi ... | 1978 | 204770 |
| [recent findings on histamine]. | | 1978 | 204810 |
| prostaglandins and sleep. awaking effect of prostaglandins and sleep pattern of essential fatty acids deficient (efad) rats. | the experiments were carried out to investigate the effects of prostaglandins (pgs) on the sleep pattern in the cat, and in normal and efad rats. the data indicate that the duration of slow wave sleep (sws) was significantly longer in efad rats compared with the normal rats. however, no difference in the rem sleep was observed between the two groups. intraventricular (i.vc. )administration of pge1, pge2 and pgf2alpha increased wakefulness without a significant alteration of rem sleep. pge1 admin ... | 1978 | 204961 |
| [functional and chemical properties of the choline-sensitive neurons in the cerebral cortex]. | | 1978 | 205053 |
| an immunofluorescence diagnostic test for feline viral rhinotracheitis. | hyperimmune serum against feline viral rhinotracheitis was produced in a goat and conjugated with a fluorescent dye. cell cultures infected with rhinotracheitis virus had positive immunofluorescence. cell cultures infected with other feline viruses and herpesviruses of other species did not fluoresce. in cats experimentally infected with rhinotracheitis virus, the virus was isolated from nasal and conjunctival swabs 1 to 9 days after inoculation. nasal smears stained with the conjugated antiseru ... | 1978 | 205147 |
| brainstem control of spinal pain-transmission neurons. | | 1978 | 205165 |
| brainstem mechanisms for rapid and slow eye movements. | | 1978 | 205169 |
| the effect of corticotropin on phospholipid metabolism in isolated adrenocortical cells. | trypsin-dispersed cat adrenocortical cells were incubated at 37 degrees c in modified eagle's medium containing [14c]arachidonic acid of sodium [14c]-acetate and then in non-radioactive medium. radioactive incorporation was obtained in all phospholipids, with the greatest amount of radioactivity in phosphatidylcholine, followed by phosphatidylethanolamine, phosphatidyl-serine, and phosphatidylinositol. concentrations of individual phospholipids generally paralleled the relative amounts of corres ... | 1978 | 205250 |
| focal penicillin epilepsy increases cyclic gmp in cerebral cortex. | | 1978 | 205316 |
| increased susceptibility to feline leukemia virus infection in cats exposed to methylnitrosourea. | exposure of adult specific-pathogen-free cats to methylnitrosourea resulted in increased susceptibility to infection by feline leukemia virus. a greater proportion of cats exposed to methylnitrosourea and feline leukemia virus (69%) became persistently viremic than those exposed to feline leukemia virus alone (17%). segmented neutrophils were reduced by 90 to 99% within 3 days following exposure to methylnitrosourea, (15 to 20 mg/kg) whereas the effects on lymphocytes and erythrocytes, although ... | 1978 | 205356 |
| involvement of the sympathetic nervous system in the urinary bladder internal sphincter and in penile erection in the anesthetized cat. | male cats were anesthetized with pentobarbital. in one series of experiments a foley catheter was placed suprapubically in the urinary bladder and physiologic saline, under a constant head of pressure, was allowed to flow at a constant rate through the bladder. alpha-adrenergic stimulants such as ephedrine, norepinephrine, or methoxamine all caused a decrease or cessation in urinary flow. this effect was reversed by the alpha-adrenergic blocking agent, phentolamine. in addition, phentolamine adm ... | 1978 | 205522 |
| [change in the reactions of isolated vascular segments to electric stimulation under the influence of inderal]. | it is shown that under the effect of inderal the relaxation of isolated vascular segments in response to electric stimulation is replaced by their contraction. in the event of initial contractile reactions these are noticeably potentiated. the conditions of the experiment do not allow the effect observed to be explained by the block of specific beta-adrenergic receptors by inderal. taking into account the data on the effect of inderal on the intracellular biochemical processes, the authors presu ... | 1978 | 205702 |
| computerized axial-tomography in the preoperative evaluation of an angiofibroma. | computerized axial tomography (cat) of the head provides the otolaryngologist with an effective diagnostic tool. this technique is particularly useful when used in the preoperative evaluation of head and neck pathology and may be used to define the extent of disease and to direct the surgical approach. the case of a 16-year-old male with an extensive angiofibroma involving the paranasal sinuses and nasopharynx is presented as an example of cat in preoperative planning of the surgical procedure. ... | 1978 | 205744 |
| adenosine cyclic 3',5'-monophosphate concentrations during the positive inotropic response of cat cardiac muscle to polymeric immobilized isoproterenol. | | 1978 | 205770 |
| effects of adrenocortical steroids and of adrenocorticotrophic hormone on (na+-k+)-atpase in immature cerebral cortex. | the effect of cortisol, methylprednisolone, and acth on (na+-k+)-atpase activity in developing cerebral cortex has been measured. stimulation of (na+-k+)-atpase by these agents has been found in whole brain homogenates of kittens as early as age 8 days, and in whole homogenates and light microsomal fractions in young rats at 14 and 28 days. (na+-k+)-atpase activity in animals treated with corticosteroids or acth for 4 days was found to be 15--30% higher than activity in littermate controls. brai ... | 1978 | 205825 |
| general pharmacology of ergot alkaloids. | ergot alkaloids possess a wide and divergent spectrum of central and peripheral pharmacodynamic actions. they interfere with different receptor sites to stimulate and/or inhibit effector structures. the concept of partial agonism on alpha-adrenoreceptors has replaced the ancient hypothesis of direct stimulation of vascular and uterine smooth muscle. the mechanisms which are considered to be relevant for the therapeutic use of dihydroergotamine, a potent drug increasing venous tone, and of bromoc ... | 1978 | 205888 |