| [relationship between infection burden and atherosclerosis and plaque feature]. | to evaluate the relationship between infection burden and coronary atherosclerosis and the plaque feature. | 2005 | 15932655 |
| [infection with chlamydia pneumoniae increases oxidative stress and accelerates the development of atherosclerosis in c57bl/6j mice]. | to evaluate the effects of chlamydia pneumoniae infection on oxidative stress and the development of atherosclerosis in c57bl/6j mice. | 2005 | 15932691 |
| chlamydophila pneumoniae induces expression of toll-like receptor 4 and release of tnf-alpha and mip-2 via an nf-kappab pathway in rat type ii pneumocytes. | the role of alveolar type ii cells in the regulation of innate and adaptive immunity is unclear. toll-like receptors (tlrs) have been implicated in host defense. the purpose of the present study was to investigate whether chlamydophila pneumoniae (i) alters the expression of tlr2 and/ortlr4 in type ii cells in a (ii) rho-gtpase- and (iii) nf-kappab-dependent pathway, subsequently (iv) leading to the production of (iv) pro-inflammatory tnf-alpha and mip-2. | 2005 | 15935092 |
| pilot study to examine the effect of antibiotic therapy on mri outcomes in rrms. | this trial examined the safety and possible mri and clinical effects of anti-chlamydial antibiotic therapy in relapsing-remitting ms (rrms). newly diagnosed ms patients were selected to participate if they showed chlamydia pneumoniae gene in their csf and had one or more enhancing lesions on brain magnetic resonance imaging (mri). after a 4-month run in phase of monthly mri, patients were randomized to receive rifampin (300 mg twice daily) and azithromycin (500 mg every other day) for 6 months o ... | 2005 | 15935383 |
| systemic markers of inflammation, endothelial dysfunction, and age-related maculopathy. | to examine the association of systemic markers of inflammatory disease and endothelial dysfunction with age-related maculopathy (arm). | 2005 | 15939388 |
| resveratrol and curcumin reduce the respiratory burst of chlamydia-primed thp-1 cells. | the intracellular bacterium chlamydia pneumoniae is involved in the inflammation process of atherosclerosis. we previously demonstrated that c. pneumonia infected monocytes (thp-1 cells) responded to stimulation by an increased respiratory burst linked to an increased nadph oxidase (nox) activity. we now tested agents acting on the assembly of the nox subunits or on protein kinase c, a trigger of nox activity. apocynin, resveratrol, rutin, quercetin, curcumin, and tocopherols were tested. the ce ... | 2005 | 15939398 |
| moxifloxacin for the treatment of acute exacerbations of chronic obstructive pulmonary disease. | the significant impact of acute exacerbations of chronic obstructive pulmonary disease (aecopd) is now recognized. this recognition has led to increased efforts to provide evidence-based, appropriate treatment of aecopd, to minimize its negative impact. this article reviews the bacterial etiology of aecopd and clinical trials (both placebo-controlled and antibiotic comparison trials) that support the use of antibiotics for aecopd, with an emphasis on the role of newer fluoroquinolones for the tr ... | 2005 | 15942884 |
| development of a hamster model of chlamydophila pneumoniae infection. | the aim of this study was to develop a new experimental model of chlamydophila pneumoniae infection in the hamster. intraperitoneal injection of c. pneumoniae purified elementary bodies (ebs) in the hamsters caused a systemic infection, since it was possible to isolate viable chlamydiae from several organs up to 14 days after infection. in particular, spleen infection was detectable up to 7 days post infection in 100% of animals. in contrast, cultures of the organs obtained from intranasally inf ... | 2005 | 15943066 |
| [aortic valve stenosis: persistence of infective agents or noninfective inflammatory process?]. | the probable risk factors leading to aortic valve calcification are not clearly defined. the cross-sectional study of 85 patients with vascular and valvular calcification was performed. correlations between the immune tests and aortic stenosis severity were investigated. the predictors of aortic valve calcification were probably c-reactive protein and interleukin-6. the predictors of aortic stenosis progression were interleukin-8, antibodies of chlamydia pneumoniae and cytomegalovirus, and dysre ... | 2004 | 15945547 |
| close association of chlamydia pneumoniae iga seropositivity by elisa with the presence of coronary artery stenosis in haemodialysis patients. | traditional risk factors of cardiovascular disease do not fully explain the accelerated atherosclerosis present in patients with end-stage renal disease (esrd). the goal of this study was to identify the association of clinical and laboratory factors including seropositivity for chlamydia pneumoniae determined by a specific enzyme-linked immunosorbent assay (elisa) with the presence of coronary artery disease identified by coronary angiography in esrd patients. | 2005 | 15956072 |
| chlamydia pneumoniae in peripheral blood mononuclear cells isolated from individuals younger than 20 years or older than 60 years. | | 2005 | 15956453 |
| serum and peripheral blood mononuclear cells infectious burden: correlation to inflammation and atherosclerosis in haemodialysis patients. | infectious agents may be implicated in the inflammatory atherosclerotic process. not only specific microorganisms but also the infectious burden, defined as the number of pathogens to which a patient is exposed, has been associated with atherosclerosis. in the present study, the infectious burden, determined directly (by identification of viable pathogens in peripheral blood mononuclear cells (pbmc)) and indirectly (by serum antibodies detection) is correlated to the inflammatory and atheroscler ... | 2005 | 15958038 |
| chlamydophila pneumoniae and mycoplasma pneumoniae: a role in asthma pathogenesis? | the potential role of atypical bacterial infection in the pathogenesis of asthma is a subject of continuing debate. there is an increasing body of literature concerning the association between the atypical bacteria chlamydophila pneumoniae and mycoplasma pneumoniae and asthma pathogenesis; however, many studies investigating such a link have been uncontrolled and have provided conflicting evidence, in part due to the difficulty in accurately diagnosing infection with these atypical pathogens. th ... | 2005 | 15961690 |
| significance of atypical pathogens among community-acquired pneumonia adult patients admitted to hospital in kuwait. | the aim of this study is to determine the microbial etiology and severity of community-acquired pneumonia (cap) in kuwait. | 2005 | 15961932 |
| myd88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of chlamydia pneumoniae pneumonia. | chlamydia pneumoniae is the causative agent of respiratory tract infections and a number of chronic diseases. here we investigated the involvement of the common tlr adaptor molecule myd88 in host responses to c. pneumoniae-induced pneumonia in mice. myd88-deficient mice were severely impaired in their ability to mount an acute early inflammatory response toward c. pneumoniae. although the bacterial burden in the lungs was comparable 5 days after infection, myd88-deficient mice exhibited only min ... | 2005 | 15964841 |
| relationship between peripheral arterial occlusive disease (paod) and chronic chlamydophila (chlamydia) pneumoniae infection. a meta-analysis. | we carried out a meta-analysis of observational case-control studies published before may 2004 to assess the degree of association between chlamydophila pneumoniae (cp) infection and paod. a search of the medline database was performed using atherosclerosis and "chlamyd* pneumoniae" as keywords. strict criteria were applied for the selection of case studies, which had to be studies of cp seroprevalence or of cp detection in patients versus controls. forty-three published studies that met these c ... | 2005 | 15968402 |
| [chlamydia pneumoniae--a new risk factor for calcific aortic stenosis?]. | nonrheumatic, calcific aortic stenosis is the main heart valve disease and the main cause of heart valve replacement in the elderly. recent studies suggest that it is based on a chronic inflammatory process. the pathogenetic mechanisms, however, are unclear. | 2005 | 15968485 |
| evaluation of chronic infectious interstitial pulmonary disease in children by low-dose ct-guided transthoracic lung biopsy. | children with chronic infectious interstitial lung disease often have to undergo open lung biopsy to establish a final diagnosis. open lung biopsy is an invasive procedure with major potential complications. transthoracic lung biopsy (tlb) guided by computed tomography (ct) is a less-invasive well-established procedure in adults. | 2005 | 15968518 |
| tyrosine phosphorylation of the chlamydial effector protein tarp is species specific and not required for recruitment of actin. | chlamydiae are obligate intracellular pathogens that efficiently induce their endocytosis by susceptible eukaryotic host cells. recently, a chlamydia trachomatis type iii secreted effector protein, tarp, was found to be translocated and tyrosine phosphorylated at the site of entry and associated with the recruitment of actin that coincides with endocytosis. c. trachomatis tarp possesses up to six direct repeats of approximately 50 amino acids each. the majority of the tyrosine residues are found ... | 2005 | 15972471 |
| chlamydia pneumoniae augments the oxidized low-density lipoprotein-induced death of mouse macrophages by a caspase-independent pathway. | chlamydia pneumoniae is a common respiratory pathogen that is associated with an increased risk of cardiovascular disease. however, the mechanisms by which c. pneumoniae contributes to cardiovascular disease have not been determined yet. c. pneumoniae infection may accelerate the death of cells within atherosclerotic lesions and contribute to the formation of unstable lesions. to test this hypothesis, the impact of c. pneumoniae infection on the death of lipid-loaded mouse macrophages was invest ... | 2005 | 15972525 |
| effect of chlamydia pneumoniae on cellular atp content in mouse macrophages: role of toll-like receptor 2. | chlamydiae are obligate intracellular gram-negative bacteria and are dependent on the host cell for atp. thus, chlamydial infection may alter the intracellular levels of atp and affect all energy-dependent processes within the cell. we have shown that both live c. pneumoniae and inactivated c. pneumoniae induce markers of cell death prior to completion of the bacterial growth cycle. as depletion of atp could account for the observed increase in cell death, the effects of c. pneumoniae on atp con ... | 2005 | 15972526 |
| [four cases of idiopathic retroperitoneal fibrosis markedly responsive to steroid therapy]. | we report four cases of idiopathic retroperitoneal fibrosis (irpf) effectively treated with steroid therapy. computed tomographic (ct) scan showed the density of soft tissue mass enveloping the abdominal aorta in four cases. from radiographic findings we made a diagnosis of irpf. management with steroid therapy over three months improved general symptoms and radiographic findings. prominent calcification in the wall of the abdominal aorta indicated that the arteriosclerosis was related to irpf. ... | 2005 | 15977597 |
| chlamydia pneumoniae genome sequence analysis and identification of hla-a2-restricted cd8+ t cell epitopes recognized by infection-primed t cells. | in the present study, we performed in silico analysis of chlamydia pneumoniae genome sequence to identify human hla-a2-restricted t cell epitopes. thirty-one chlamydia-specific protein antigens were selected and peptides were derived thereof using an hla-a2 epitope predictive algorithm. firstly, we tested binding of 55 selected 9mer peptides to hla-a2 in vitro. next, infection of hla-a2 transgenic mice with c. pneumoniae elementary bodies and assessment of effector cd8+ t cells allowed us to ide ... | 2005 | 15982792 |
| [serologic examination of patients with prolonged cough in anamnesis]. | serological examinations of patients with prolonged cough in history, made at an allergy center, revealed, in 56% of them, igg to antigens of chlamydia pneumoniae and c. psittaci; antibodies to m. pneumonie were detected in 25% of them. it is expedient to diagnose serologically opportunistic infections in order to prevent chronic disease forms and further allergization. | 2005 | 15986800 |
| high rate of seropositivity of chlamydia pneumoniae iga in male patients with nonalcoholic steatohepatitis. | the aim of this study was to investigate if there was any relationship between nonalcoholic steatohepatitis and the rate of chlamydia pneumoniae seropositivity in a male population. fifteen men with nonalcoholic steatohepatitis and 20 healthy men were enrolled in the study. the seropositivity rate of chlamydia pneumoniae immunoglobulin a in the nonalcoholic steatohepatitis and control groups was 53.3 and 5%, respectively. the rate of chlamydia pneumoniae immunoglobulin a positivity was significa ... | 2005 | 15986871 |
| chlamydia pneumoniae and atherosclerosis: from koch postulates to clinical trials. | atherosclerosis is increasingly viewed as an inflammatory process. a number of infectious agents have been implicated in the pathogenesis of coronary artery disease. chlamydia pneumoniae has been the most popular and well-studied of these pathogens. it is difficult to prove a causal relationship which requires the fulfillment of koch's postulates, first developed in the late 1800s, to establish an infectious agent as the cause of a disease process. this paper reviews the evidence for and against ... | 2005 | 15991152 |
| persistent infection and vascular disease: a systematic review. | more than 150 epidemiological or clinical studies have reported on associations between vascular disease and the presence of certain persistent bacterial and viral agents, or of clinical conditions (e.g., periodontal disease) that are associated with persistent infection. this article provides a review of such studies, particularly in relation to helicobacter pylori, chlamydia pneumoniae, dental disease and cytomegalovirus (cmv), as well as references to possible mechanisms. the association betw ... | 1998 | 15991962 |
| grepafloxacin: an overview of antibacterial activity, pharmacokinetics, clinical efficacy and safety. | the treatment of respiratory tract infection is the most common reason for antibiotic prescribing. however, therapeutic options are diminishing as antibiotic resistance to penicillins and macrolides in key respiratory pathogens is increasing. as resistance increases, there are parallel rises in the number of treatment failures and the total cost of infection management. new generation broad-spectrum fluoroquinolones, such as grepafloxacin, have recently been recommended as a first-line treatment ... | 1999 | 15992094 |
| seropositivity to chlamydia pneumoniae or helicobacter pylori and coronary artery disease. | our aim was to investigate the relationship between the serologic status concerning chlamydia pneumoniae and helicobacter pylori with the presence of coronary artery disease (cad), which remain a controversial issue in literature. we studied 208 patients with cad and 94 controls with no evidence of obstructive cad; all of them angiographically confirmed. the seropositivity to c. pneumoniae was 91% in patients with cad vs 86% in controls (p>0.05). the h. pylori seroprevalence rates were 77% and 6 ... | 2006 | 15993502 |
| correlation of chlamydia pneumoniae infection with primary biliary cirrhosis. | to evaluate the association between chlamydia pneumoniae (cpn) infection and primary biliary cirrhosis (pbc). | 2005 | 15996040 |
| [the role of chlamydia pneumoniae in the pathogenesis of abdominal aortic aneurysm]. | abdominal aortic aneurysm is a disease with complicated pathogenesis. the known risk factors do not explain fully the mechanism of pathological change formation, and their modification does not stop but only can retard the illness progression. since an exacerbated inflammation has been detected in the aneurysms wall, the hypothesis should be taken under consideration that some role in the disease development may play microorganisms. most attention has been concentrated on chlamydia pneumoniae, b ... | 2005 | 15997650 |
| the load of chlamydia pneumoniae in the alzheimer's brain varies with apoe genotype. | studies from this laboratory have indicated that the intracellular eubacterial respiratory pathogen chlamydophila (chlamydia) pneumoniae is commonly found in brain regions displaying characteristic neuropathology in patients with late-onset alzheimer's disease (ad) but not in congruent samples from non-ad control individuals. in later work, we provided evidence suggesting that some relationship exists between the apoe epsilon4 gene product and the pathobiology of this organism. in the present re ... | 2005 | 15998578 |
| frequency of detection of picornaviruses and seven other respiratory pathogens in infants. | previous studies in which molecular-based techniques have been used to identify the causative pathogens of respiratory tract infection have investigated hospitalized children only. we report a prospective study designed to determine the frequency and clinical presentation of community-acquired respiratory illness in infancy associated with 8 common respiratory pathogens. | 2005 | 15999002 |
| development and evaluation of chlamylege, a new commercial test allowing simultaneous detection and identification of legionella, chlamydophila pneumoniae, and mycoplasma pneumoniae in clinical respiratory specimens by multiplex pcr. | this study describes the development and evaluation of a new commercial test, chlamylege (argene inc.), which allows the simultaneous detection in respiratory samples of chlamydophila pneumoniae, mycoplasma pneumoniae, and most legionella species, as well as pcr inhibitors, by using a multiplex pcr and microplate hybridization. the sensitivities of chlamylege were 1 x 10(-3) ifu, 5 x 10(-2) color-changing units, and 1 cfu per reaction tube for c. pneumoniae, m. pneumoniae, and legionella pneumop ... | 2005 | 16000443 |
| multiple genotypes of chlamydia pneumoniae identified in human carotid plaque. | chlamydia pneumoniae is an obligate intracellular respiratory pathogen that causes 10 % of community-acquired pneumonia and has been associated with cardiovascular disease. both whole-genome sequencing and specific gene typing suggest that there is relatively little genetic variation in human isolates of c. pneumoniae. to date, there has been little genomic analysis of strains from human cardiovascular sites. the genotypes of c. pneumoniae present in human atherosclerotic carotid plaque were ana ... | 2005 | 16000718 |
| community-acquired bacteria frequently detected by means of quantitative polymerase chain reaction in nosocomial early-onset ventilator-associated pneumonia. | to test whether real-time polymerase chain reaction allows for rapid quantitative detection of streptococcus pneumoniae, chlamydia pneumoniae, mycoplasma pneumoniae, and legionella pneumophila in bronchoalveolar lavage fluids and to determine the prevalence of these pathogens in nosocomial ventilator-associated pneumonia. | 2005 | 16003053 |
| role of anti-infective strategies in the prevention of stroke. | case-control studies and a few prospective studies have indicated that chronic infections may add to the risk of stroke and that acute infections may act as trigger factors for stroke. such chronic infections include periodontal disease, infection with chlamydia pneumoniae or helicobacter pylori, and chronic bronchitis. a causal role of these infectious diseases has not been proved, given conflicting study results, possible residual confounding in observational studies, and the lack of evidence ... | 2005 | 16004850 |
| [chlamydia pneumoniae and mycoplasma pneumoniae in calcified nodes of stenosed aortic valves]. | we investigated whether chlamydia pneumoniae (cp) and mycoplasma pneumoniae (mp) are present in aortic valve stenosis (as). | 2005 | 16007307 |
| chlamydia lps and momp seropositivity are associated with different cytokine profiles in patients with coronary heart disease. | persistent chlamydia pneumoniae infection within atherosclerotic plaques are possible stimulators of inflammation in atherosclerosis. why the microbe develops persistency in some individuals is unknown, but experimental studies in cell cultures and animals have demonstrated the levels of gamma interferon (ifngamma) and interleukin 10 (il-10) to be of crucial importance. | 2005 | 16008544 |
| silencing or permanent activation: host-cell responses in models of persistent chlamydia pneumoniae infection. | chlamydia pneumoniae causes respiratory infections. in chronic diseases associated with chlamydia, such as arteriosclerosis, c. pneumoniae is present in a persistent form, which might participate in pathogenesis of chronic inflammatory disease. to elucidate how these intracellular bacteria modulate host-cells during persistence, we compared the expression pattern of a range of host genes after short (24 h) and long (up to 7 days) times of chlamydia infection in hela-cells. one day post infection ... | 2005 | 16008577 |
| systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops. | public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. the available data offers new opportunities to address questions about bacterial genome evolution, a task that requires reliable fine comparison data of closely related genomes. recent analyses have shown, using pairwise whole genome alignments, that it is possible to segment bacterial genomes into a common conserved backbone and strain-specific sequences called loops. | 2005 | 16011797 |
| interactions of oral pathogens with toll-like receptors: possible role in atherosclerosis. | toll-like receptors (tlr) function as important signal transducers that mediate innate immune and inflammatory responses to pathogens through pattern recognition of virulence molecules. although tlrs mediate protection against infection, it is also likely that they may have a pathophysiologic role in certain inflammatory diseases, such as atherosclerosis. in atherosclerotic lesions, endothelial cells and macrophages have been shown to upregulate tlr expression and may respond to tlr agonists of ... | 2002 | 16013219 |
| mycoplasma pneumoniae and chlamydia pneumoniae chronic cough in children: efficacy of clarithromycin. | | 2005 | 16023330 |
| a multiplex pcr for detection of mycoplasma pneumoniae, chlamydophila pneumoniae, legionella pneumophila, and bordetella pertussis in clinical specimens. | a multiplex pcr was developed that is capable of detecting four of the most important bacterial agents of atypical pneumonia, mycoplasma pneumoniae, chlamydophila pneumoniae, legionella pneumophila, and bordetella pertussis in uncultured patient specimens. these organisms cause similar symptomologies and are often not diagnosed because they are difficult to identify with classical methods such as culture and serology. given this, the overall impact of these pathogens on public health may be gros ... | 2005 | 16024220 |
| a positive association of peripheral arterial occlusive disease (pad) and chlamydophila (clamydia) pneumoniae. | the relationship between chlamydophila pneumoniae (cp) infection and peripheral arterial occlusive disease (pad) was studied by analyzing clinical samples from 95 patients with pad and 100 controls. the following investigations were conducted: igg and iga against lipopolysaccharide (lps) and against purified cp-specific antigens from elementary bodies (eb) with elisa; anti-eb igg, with mif; cp dna in arterial biopsy and peripheral blood mononuclear cells with heminested pcr; lps with elisa; and ... | 2005 | 16028201 |
| [biomechanical characterization of the wall of abdominal aortic aneurysm exposed to infection]. | presented herein are three cases of biomechanical evaluation of the wall of the normal abdominal aorta, of the wall of an abdominal aortic aneurysm infected by chlamydia pneumoniae, and of the wall of an abdominal aortic aneurysm uninfected by chlamydia pneumoniae. the samples of the aortic wall and aortic aneurysm were tailored in two directions--transverse and longitudinal. the samples were inserted into the appliance 858 mini bionix produced by the mts for testing the strength of materials an ... | 2005 | 16034320 |
| macrolides for chronic asthma. | asthma is a chronic disease of the airways in which inflammation of the respiratory mucosa plays a crucial role. the mechanisms responsible for the maintaining of this inflammatory response are only partially known and there is evidence that a role could be paid by chronic infection by intracellular pathogens (such as chlamydia pneumoniae). macrolides are antibiotics with both antimicrobic and antiinflammatory activities and thus their use in asthmatic patients could lead to reduction of the air ... | 2005 | 16034882 |
| [meta-analysis on the relationship of chlamydia pneumonia infection and coronary heart disease]. | to determine the relationship of chlamydia pneumonia (cp) infection and coronary heart disease (chd). | 2005 | 16038273 |
| chlamydia conjunctivitis and central retinal vein occlusion. | to report a case of coexistent chlamydia conjunctivitis and central retinal vein occlusion (crvo) in which both problems improved significantly after oral doxycyline. | 2005 | 16038672 |
| leukocyte count is associated with reduced endothelial reactivity. | leukocyte count has been associated with cardiovascular and cerebrovascular disease in several studies. we hypothesized that white blood cell count is associated with endothelial reactivity. | 2005 | 16039287 |
| degradation of chlamydia pneumoniae by peripheral blood monocytic cells. | chlamydia pneumoniae is a common human respiratory pathogen that has been associated with a variety of chronic diseases, including atherosclerosis. the role of this organism in the pathogenesis of atherosclerosis remains unknown. a key question is how c. pneumoniae is transferred from the site of primary infection to a developing atherosclerotic plaque. it has been suggested that circulating monocytes could be vehicles for dissemination of c. pneumoniae since the organism has been detected in pe ... | 2005 | 16040967 |
| chlamydia pneumoniae uses the mannose 6-phosphate/insulin-like growth factor 2 receptor for infection of endothelial cells. | several mechanisms for attachment and entry of chlamydia have been proposed. we previously determined that the major outer membrane protein of chlamydia trachomatis is glycosylated with a high-mannose oligosaccharide, and a similar structure inhibited the attachment and infectivity of c. trachomatis in epithelial cells. because insulin-like growth factor 2 (igf2) was shown to enhance the infectivity of chlamydia pneumoniae but not c. trachomatis in endothelial cells, a hapten inhibition assay wa ... | 2005 | 16040974 |
| immuno-histochemical demonstration of the role of chlamydiaceae in renal, uterine and salpingeal disease of the koala, and demonstration of chlamydiaceae in novel sites. | numerous bacteria, including chlamydophila pecorum and chlamydophila pneumoniae, are known to occur in diseased sites in koalas. in the present study the significance of such organisms was investigated by demonstrating their distribution in situ, in tissues collected opportunistically from wild koalas. chlamydiaceae were demonstrated in epithelial cells and macrophages in association with pyogranulomatous pyelonephritis (8/11 kidneys), focal interstitial nephritis (3/21), and active inflammation ... | 2005 | 16045922 |
| detection of helicobacter pylori and chlamydia pneumoniae dna in human coronary arteries and evaluation of the results with serologic evidence of inflammation. | atherosclerosis is pathologically similar to a chronic inflammatory response. recent reports have suggested that chlamydia pneumoniae (c. pneumoniae) and helicobacter pylori (h. pylori) play a role in the pathogenesis of atherosclerosis but this relation has not been confirmed on an inflammatory background. | 2005 | 16047055 |
| chlamydia pneumoniae and acute coronary syndrome. | | 2005 | 16079381 |
| chlamydia pneumoniae and acute coronary syndrome. | | 2005 | 16080248 |
| chlamydia pneumoniae and acute coronary syndrome. | | 2005 | 16080249 |
| chlamydia pneumoniae and acute coronary syndrome. | | 2005 | 16080250 |
| etiology of community acquired pneumonia among adult patients requiring hospitalization in taiwan. | there has not been a comprehensive multi-center study investigating the microbial profile of community acquired pneumonia (cap) in taiwan. | 2005 | 16085210 |
| the mechanism of base excision repair in chlamydiophila pneumoniae. | repair of damaged dna is of great importance in maintaining genome integrity, and there are several pathways for repair of damaged dna in almost all organisms. base excision repair (ber) is a main process for repairing dna carrying slightly damaged bases. several proteins are required for ber; these include dna glycosylases, ap endonuclease, dna polymerase, and dna ligase. in some bacteria the single-stranded specific exonuclease, recj, is also involved in ber. in this research, six chlamydiophi ... | 2005 | 16085468 |
| a systematic comparison of the quality and volume of published data available on novel risk factors for stroke versus coronary heart disease. | to identify new treatments to prevent stroke, it is important that we have reliable data on potential novel risk factors. | 2005 | 16088113 |
| the relationship between chlamydia trachomatis and chlamydia pneumoniae as the cause of neonatal conjunctivitis (ophthalmia neonatorum). | the authors examined 130 newborns and nursery children from september 1999 till may 2003 from the prague district for the surmise of chlamydial conjunctivitis. chlamydia infections were detected in conjunctival smears. chlamydia trachomatis was confirmed in 20 (15.3%) using ligase chain reaction and c. pneumoniae in 16 (12.3%) children using an indirect immunofluorescent method. direct captures of chlamydial infections of newborns were included in the study. the authors had also examined 671 new ... | 2005 | 16088243 |
| the antibiotic treatment of severe community-acquired pneumonia admitted to the critical care unit. | community-acquired pneumonias (cap) are still caused by streptococcus pneumoniae, hemophilus influenzae, or moraxella catarrhalis. legionella and chlamydia pneumoniae have been defined as important atypical pathogens causing cap. klebsiella causes cap primarily in patients with chronic alcoholism or in chronic care facilities. normal hosts do not present with "unusual pathogens'' e.g., staphylococcus aureus or pseudomonas aeruginosa. the clinical severity of a bacterial pneumonia has important p ... | 2000 | 16088719 |
| chlamydia pneumoniae pneumonia. | chlamydia pneumoniae is a common cause of community-acquired pneumonia. at present there is no "gold'' standard for diagnosis and there is no easily accessible means of rapid diagnosis available. the best indication of acute c. pneumoniae infection is a fourfold rise in antibody titer, accompanying a positive polymerase chain reaction or culture. c. pneumoniae is usually associated with nonsevere clinical manifestations but the features will vary depending upon the occurrence as primary or reinf ... | 2000 | 16088739 |
| the failure of antibiotics to prevent heart attacks. | | 2005 | 16096289 |
| [association between carotid atherosclerosis, inflammatory markers and chlamydia pneumoniae infection]. | the aim of this study was to assess the correlation between morphological markers of carotid atherosclerosis, such as intima-media thickness (imt) and the cross-sectional plaque area with markers of inflammation and c. pneumoniae infection. | 2005 | 16096932 |
| clearance of chlamydia pneumoniae infection in h-2 class i human leucocyte antigen-a2.1 monochain transgenic mice. | cd8+ t cells have been suggested to play an important role in protective immunity against pulmonary chlamydia pneumoniae infection in mice. moreover, several classical major histocompatibility complex class i - restricted cytotoxic cd8+ t lymphocytes (ctl) specific for c. pneumoniae- derived peptides have been identified. here, we studied the outcome of c. pneumoniae infection in human leucocyte antigen (hla)-a2.1 transgenic mice (hhd mice) that are only able to express a classical human class i ... | 2005 | 16101819 |
| cross-reactivity of groel antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis. | chronic infections such as those caused by chlamydia pneumoniae and periodontopathic bacteria such as porphyromonas gingivalis have been associated with atherosclerosis, possibly due to cross-reactivity of the immune response to bacterial groel with human heat shock protein (hhsp) 60. | 2005 | 16101965 |
| [antibodies against chlamydophila in patients with acute myocardial infarction and coronary risk and their association with mortality]. | the primary aim of this study was to determine whether antibodies against chlamydophila pneumoniae in patients with acute myocardial infarction (ami) and coronary risk factors are associated with death. | 2005 | 16104465 |
| [diagnostic tests: chlamydia trachomatis, chlamydophila pneumoniae]. | | 2005 | 16111232 |
| delivery of chlamydia pneumoniae to the vessel wall aggravates atherosclerosis in ldlr-/- mice. | the role of chlamydia pneumoniae in atherosclerosis is still debated. in this study a novel mouse model was applied to determine the direct impact of c. pneumoniae on the arterial wall and the development of atherosclerosis. | 2006 | 16112098 |
| chlamydophila pneumoniae. mechanisms of target cell infection and activation. | chlamydophila (chlamydia) pneumoniae, a gram-negative obligate intracellular bacterium, is a widespread respiratory pathogen. chronic c. pneumoniae infection has been suggested as a trigger/promoter of inflammation that may result in vascular lesions. although the genome of c. pneumoniae has been sequenced completely this information has not yet led to an understanding of the mechanisms of acute infection and target cell activation nor to the identification of potential chlamydial virulence fact ... | 2005 | 16113821 |
| chlamydia pneumoniae induces nitric oxide synthase and lipoxygenase-dependent production of reactive oxygen species in platelets. effects on oxidation of low density lipoproteins. | there is increasing evidence that chlamydia pneumoniae is linked to atherosclerosis and thrombosis. in this regard, we have recently shown that c. pneumoniae stimulates platelet aggregation and secretion, which may play an important role in the progress of atherosclerosis and in thrombotic vascular occlusion. the aims of the present study were to investigate the effects of c. pneumoniae on platelet-mediated formation of reactive oxygen species (ros) and oxidation of low-density lipoprotein (ldl) ... | 2005 | 16113822 |
| community epidemiology of chlamydia and mycoplasma pneumoniae in lrti in france over 29 months. | the role of chlamydia pneumoniae (cp) and mycoplasma pneumoniae (mp) in lower respiratory tract infections (lrti) is still little known in community settings. | 2005 | 16119439 |
| effect of simvastatin, an established lipid-lowering drug, on pulmonary chlamydia pneumoniae infection in mice. | the effects of simvastatin treatment on chlamydia pneumoniae lung infection, inflammation, and serum lipids in mouse model were studied. simvastatin decreased viable chlamydial counts and increased inflammatory cell infiltrates in the lung tissue, suggesting that simvastatin treatment had both antichlamydial and immunomodulatory effects during an acute c. pneumoniae infection. | 2005 | 16127082 |
| azithromycin reduces chlamydia pneumoniae-induced attenuation of enos and cgmp production by endothelial cells. | intracellular infections with cytomegalovirus (cmv) or chlamydia pneumoniae (cp) may play a role in the aetiology of atherosclerosis. nitric oxide (no) is a key regulator of endothelial function. under pathological conditions uncoupling of endothelial nitric oxide synthase (enos) leads to vessel damage as a result of production of oxygen radicals instead of no. we hypothesized that infection-induced atherosclerosis is initiated by changes in no metabolism and may be reversed by azithromycin trea ... | 2005 | 16128864 |
| [prevalence of anti-chlamydophila pneumoniae antibodies in patients with intrinsic asthma]. | chlamydophila pneumoniae is a respiratory pathogen which has been involved in the pathogenesis of a number of chronic diseases. we studied the association between igg antibodies against c. pneumoniae and intrinsic asthma in adults. c. pneumoniae igg serum titers were determined by enzymatic immunoassay in 55 adult patients and 87 healthy controls. a significant association was found between anti-c. pneumoniae antibodies and intrinsic asthma, as compared to the control group (23.6% vs. 10.3%, p < ... | 2005 | 16130036 |
| presence of chlamydia pneumoniae in patients with and without atherosclerosis. | data published over the past decade show that chlamydia pneumoniae is likely associated with the development of atherosclerosis. the aim of this study was to ascertain whether c. pneumoniae infections occur more frequently in patients with atherosclerosis than in healthy subjects. a total of 517 persons were studied. serum samples, leukocytes, and tissue samples were assayed for the presence of c. pneumoniae-specific igg and iga antibodies and c. pneumoniae dna. c. pneumoniae dna was found in re ... | 2005 | 16133407 |
| detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis. | to examine a possible relationship between chlamydia pneumoniae infection and multiple sclerosis (ms), we undertook an immunohistochemical (ihc), molecular, and ultrastructural comparison of central nervous system (cns) tissue and cerebrospinal fluid (csf) sediment from patients with ms and control individuals with other neurological diseases (onds). in 7 of 20 ms cases, ihc staining was seen in association with ependymal surfaces and periventricular regions of formalin-fixed brain tissue, by us ... | 2005 | 16136465 |
| the role of chlamydia pneumoniae in multiple sclerosis: real or fictitious? | | 2005 | 16136478 |
| total hip arthroplasty infection with chlamydia pneumoniae and mycobacterium chelonae. | | 2005 | 16138477 |
| in vivo treatment of acute chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model. | increasing evidence suggests that plant polyphenolic compounds may protect from cardiovascular diseases, which have been addressed to their antioxidative properties. in addition, these compounds have been shown to possess anti-inflammatory and anti-microbial potential. in the present study we tested the effects of two flavonoid compounds, quercetin and luteolin, and one alkyl gallate, octyl gallate, on the course of acute chlamydia pneumoniae infection in vivo. c57bl/6j mice were treated with qu ... | 2005 | 16139801 |
| the role of atypical bacteria in chronic rhinosinusitis. | this study examines the presence of atypical bacteria in chronic rhinosinusitis (crs) by utilizing the polymerase chain reaction (pcr). | 2005 | 16143191 |
| chlamydophila pneumoniae and mycoplasma pneumoniae in respiratory specimens of children with chronic lung diseases. | persistent infection with mycoplasma pneumoniae and chlamydophila pneumoniae has been implicated in the progression or induction of asthma and chronic obstructive pulmonary disease. evidence for this hypothesis has been obtained in adults either by serological methods or by direct pathogen detection using invasive procedures. | 2005 | 16143584 |
| depletion of resident chlamydia pneumoniae through leukoreduction by filtration of blood for transfusion. | current studies indicate that a significant percentage of healthy blood donors carry chlamydia pneumoniae in their blood. although the clinical significance of such findings is unknown, eradication of such bacteria from blood components may contribute to transfusion safety. deletion of c. pneumoniae in red blood cell (rbc) units was accomplished through leukoreduction by filtration. the presence of bacteria in rbc units before and after leukoreduction was assessed by real-time pcr using primers ... | 2005 | 16145110 |
| evaluation of the association between atypical bacteria infections and respiratory tract diseases with emphasis on bronchial asthma exacerbations in children. | mycoplasma pneumoniae and chlamydia pneumonie are important etiological agents responsible for human respiratory tract diseases. recently, these atypical microorganisms received much attention regarding their role in bronchial asthma pathogenesis, which is one of the most frequent chronic diseases in children. the aim of the study was to investigate the association between infections caused by these pathogens and respiratory tract diseases in children. levels of m. pneumoniae and c. pneumoniae-s ... | 2004 | 16145964 |
| analysis of chlamydia pneumoniae-specific oligoclonal bands in multiple sclerosis and other neurologic diseases. | paired serum and cerebrospinal fluid (csf) specimens were investigated for chlamydia pneumoniae-specific oligoclonal bands (ocbs) to determine band specificity in multiple sclerosis (ms). | 2005 | 16146493 |
| comparison of intranasal and transcutaneous immunization for induction of protective immunity against chlamydia muridarum respiratory tract infection. | chlamydia pneumoniae causes a range of respiratory infections including bronchitis, pharyngitis and pneumonia. infection has also been implicated in exacerbation/initiation of asthma and chronic obstructive pulmonary disease (copd) and may play a role in atherosclerosis and alzheimer's disease. we have used a mouse model of chlamydia respiratory infection to determine the effectiveness of intranasal (in) and transcutaneous immunization (tci) to prevent chlamydia lung infection. female balb/c mic ... | 2006 | 16153755 |
| associations between dimensions of job stress and biomarkers of inflammation and infection. | the objective of this study was to examine associations between dimensions of job stress and indicators of chronic inflammation and infection. | 2005 | 16155472 |
| early detection and successful therapy of fulminant chlamydia pneumoniae myocarditis. | we report a case involving a young female patient with chlamydia pneumoniae myocarditis who required assist device therapy for acute heart failure. early diagnosis was provided by endomyocardial biopsy, and tailored antibiotic therapy facilitated quick recovery of myocardial function. this is the first case to report detecting c pneumoniae as the pathogen responsible for fulminant myocarditis while the patient was still alive and to report long-term follow-up data. | 2005 | 16156318 |
| self-limiting pneumonia due to chlamydia pneumoniae. | a case of self-limiting pneumonia due to chlamydia pneumoniae is described. a 39-year-old male visited our hospital complaining of a persistent cough. no antibiotics were administered to this patient because of the absence of fever and a mild positive inflammatory response, but an infiltrate on a chest radiograph improved. finally, a diagnosis of c. pneumoniae pneumonia was made by seroconversion of the c. pneumoniae-specific antibody and detection of the c. pneumoniae gene in bronchoalveolar la ... | 2005 | 16157990 |
| chlamydia pneumoniae pneumonia and mycoplasma pneumoniae pneumonia: comparison of clinical findings and ct findings. | the objective of this study was to identify the clinical and pulmonary ct findings associated with chlamydia pneumoniae pneumonia and to compare them with those of mycoplasma pneumoniae pneumonia. the clinical features and ct scans of 40 patients with c. pneumoniae pneumonia and 42 patients with m. pneumoniae pneumonia were retrospectively reviewed. there were no significant differences between the two etiologic agents with regard to clinical signs. chest ct findings in patients with c. pneumoni ... | 2005 | 16163032 |
| [etiology of community-acquired pneumonia in immunocompetent adults]. | in an ideal clinical setting, empiric antimicrobial treatment prescribed in adult community acquired pneumonia (cap) should be based on national etiological surveillance and in vitro susceptibility assays. available information about etiology in ambulatory patients and intensive care unit (icu) patients is scarce, compared to information obtained in hospitalized patients. in studies designed to explore the etiology of pneumonia, no microorganism is detected in 40-50% of patients, a fact that rep ... | 2005 | 16163415 |
| [microbiologic diagnosis of community-acquired pneumonia in adults]. | microbiological analysis allows us to identify the etiology of pneumonia and its in vitro susceptibility pattern. antibiotic treatment directed against a known pathogen enables us to narrow antibacterial spectrum of action, and to reduce costs, drug adverse effects risk and antibiotic resistance. however it is unnecessary to perform extended microbiological studies in all patients with community acquired pneumonia (cap). etiological studies must be based in pneumonia severity, epidemiological ri ... | 2005 | 16163417 |
| [severe community-acquired pneumonia in adults]. | patients with severe community acquired pneumonia (cap) need continuous surveillance and monitoring at intensive care units (icu), where they can receive specialized support as mechanical ventilation and/or hemodynamic support. patients that require icu admittance represent 10 to 30% of all patients interned because a pneumonia. in this category, high complication rate, prolonged hospital stay and high mortality rate are the rule. the american thoracic society (ats) criteria for severe pneumonia ... | 2005 | 16163419 |
| [national consensus for management of community acquired pneumonia in adults]. | community acquired pneumonia (cap) is an acute respiratory infection that affects pulmonary parenchyma, and is caused by community acquired microorganisms. in chile, pneumonia represents the main cause of death due to infectious diseases and is the third specific cause of mortality in adults. in 1999, an experts committee in representation of "sociedad chilena de enfermedades respiratorias", presented the first national guidelines for the treatment of adult community acquired pneumonia, mainly b ... | 2005 | 16163422 |
| sudden psychotic episode probably due to meningoencephalitis and chlamydia pneumoniae acute infection. | since 9% to 20% of all cases of acute psychosis presenting to an emergency department (ed) are due to a general medical condition, cautious medical workup should be mandatory in such patients. differential diagnosis must consider conditions as diverse as renal failure or cns infection. acute chlamydia pneumoniae infection usually causes a self-limited respiratory syndrome. rarely, acute neurological complications occur, with acute meningoencephalitis most frequently reported. diagnosis requires ... | 2005 | 16164756 |
| serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia. | chlamydiae are obligate intracellular bacteria, causing a variety of diseases, i.e. pneumonia, sexually transmitted disease, conjunctivitis and zoonosis. tryptophan depletion by interferon-gamma (ifn-gamma) is the most important host defence system against chlamydial infection. thus chlamydial tryptophan metabolism is thought to play key roles for ifn-gamma resistance, persistent infection and host/tissue tropisms. we tested tryptophan derivatives for activity against chlamydia-infected cells. | 2005 | 16172105 |
| lack of pbc-specific antimitochondrial antibodies in patients with chlamydia pneumoniae infection. | | 2005 | 16174090 |
| protective effect of doxycycline use on coronary artery disease? | the potential role of chlamydia pneumoniae infection in the pathogenesis of atherosclerosis has received increasing attention. the present study was conducted to test the hypothesis that use of doxycycline in doses prescribed in routine clinical practice for brucellosis, decreases the risk of coronary artery disease (cad). | 2006 | 16176834 |