| [signs of active infection with chlamydia pneumoniae in patients with coronary heart disease]. | possible relationship between chlamydia pneumoniae (cpn) infection and atherosclerosis has been documented in many seroepidemiological, histological and biological studies. the objectives of the present study were to find out whether serological signs of active cpn infection in patients with coronary heart disease (chd) are associated with the presence of bacterial dna in peripheral blood and to correlate with clinical symptoms and to study the dynamics of the markers of cpn infection within a s ... | 2004 | 15730214 |
| [chlamydia pneumoniae infection increases the risk of coronary artery disease in the patients with dyslipidemia]. | to investigates the role of chlamydia pneumoniae (cp) infection in the development of coronary artery disease (cad) in the patients with dyslipidemia, and to examine the gender related differences in this role. | 2004 | 15730813 |
| age alterations in extent and severity of experimental intranasal infection with chlamydophila pneumoniae in balb/c mice. | the intracellular bacterium chlamydophila ("chlamydia") pneumoniae is a pathogen for several respiratory diseases and may be a factor in the pathogenesis of chronic diseases of aging including atherosclerosis and alzheimer's disease. we assessed whether aging is coupled with increased burden of infection in balb/c mice after intranasal infection by c. pneumoniae. six- and twenty-month-old balb/c mice were infected intranasally with 5 x 10(4) inclusion forming units (ifu) or 5 x 10(5) ifu of c. p ... | 2005 | 15731073 |
| production of a proteolytically active protein, chlamydial protease/proteasome-like activity factor, by five different chlamydia species. | we have previously identified a chlamydial protein, chlamydial protease/proteasome-like activity factor (cpaf), for degrading host transcription factors in cells infected with the human chlamydial species chlamydia trachomatis or chlamydia pneumoniae. we now report that functional cpaf was also produced during infection with the species chlamydia muridarum, chlamydia psittaci, and chlamydia caviae, which primarily infect nonhuman hosts. | 2005 | 15731091 |
| chlamydial antibodies and risk of prostate cancer. | we assessed the risk of prostate cancer by exposure to chlamydia trachomatis. | 2005 | 15734962 |
| the bronchial lavage of pediatric patients with asthma contains infectious chlamydia. | there has been a worldwide increase in the incidence of asthma, and the disease has greatly impacted the public health care system. chlamydia pneumoniae has been reported as a possible contributing factor in asthma. the organism has been detected by polymerase chain reaction (pcr) in bronchial tissue, but there has been no direct evidence of viability. to determine the frequency of viable chlamydia in children, blood and bronchoalveolar lavage were collected from 70 pediatric patients undergoing ... | 2005 | 15735056 |
| chlamydia pneumoniae as risk factor of cardiovascular disease in dialysis patients. | | 2005 | 15742303 |
| secondary prevention of atherosclerosis through chlamydia pneumoniae eradication (space trial): a randomised clinical trial in patients with peripheral arterial disease. | sero-epidemiological and experimental studies suggest that chlamydia pneumoniae infections play an important role in the development of atherosclerosis. clinical trials have shown contradictory results regarding the efficacy of antibiotics to prevent atherosclerosis-related complications in patients with coronary artery disease. our aim was to study the effect of a short course of azithromycin on the incidence of cardiovascular events and peripheral vascular function in patients with stable peri ... | 2005 | 15749042 |
| effect of clarithromycin treatment on chlamydia pneumoniae in vascular tissue of patients with coronary artery disease: a randomized, double-blind, placebo-controlled trial. | several small clinical trials have indicated that antibiotic treatment of chlamydia pneumoniae infection is associated with a better outcome in patients with coronary artery disease (cad). it has not been demonstrated whether antibiotic treatment eradicates c. pneumoniae from vascular tissue. the aim of the present study was to assess the effect of clarithromycin on the presence of c. pneumoniae in the vascular tissue of patients with cad. patients who had cad and who were waiting for coronary a ... | 2005 | 15750103 |
| chlamydia pneumoniae seropositivity and risk of ischemic stroke: a nested case-control study. | chlamydia pneumoniae has been linked with increased risk of cardiovascular disease, but data on stroke are sparse. we examined whether seropositivity to chlamydia pneumoniae was associated with the risk of ischemic stroke in a nested case-control study. data on chlamydia pneumoniae serology, lifestyle factors, and medical history were obtained at baseline. verified cases (n = 254) were compared with gender- and age-matched controls (n = 254). positive iga (> or = 1:16) or igg (> or = 1:64) titer ... | 2005 | 15756905 |
| chlamydia pneumoniae infection in abdominal aortic aneurysm (aaa) patients and its clinical impact. | the aim of our study was to assess the presence of chlmydia pneumoniae infection in aaa patients and to evaluate its association with clinical symptoms and histological signs of inflammation in the aortal wall. fifty-two aaa patients participated in the research. thirty healthy controls took part in serological examination. c. pneumoniae was detected by pcr and immunofluorescence in situ reaction in aorta samples of 84.6% and 86.54% of the patients, respectively. serological markers of chronic c ... | 2004 | 15757203 |
| [organizing pneumonia--analysis of 18 own cases]. | organizing pneumonia (op) is a rarely diagnosed disease, however the incidence ratio was estimated as 6-7/100000. disease can occur in cryptogenic form or as a secondary reaction to various noxious agents, drugs, and ionising radiation, as a concomitant disease to infections, lympho- and myeloproliferative disorders, and connective tissue diseases. symptoms of op are non-specific therefore lung biopsy and histological examination are necessary for diagnosis. eighteen cases of op, 15 women and 3 ... | 2004 | 15757271 |
| moxifloxacin in respiratory tract infections. | moxifloxacin is a fourth-generation fluoroquinolone that has been shown to be effective against respiratory pathogens, including gram-positive (streptococcus pneumoniae), gram-negative (haemophilus influenzae, moraxella catarrhalis), and atypical strains (chlamydia pneumoniae, mycoplasma pneumoniae), as well as multi-drug resistant s. pneumoniae, including strains resistant to penicillin, macrolides, tetracyclines, trimethoprim/sulfamethoxazole and some fluoroquinolones. moxifloxacin is highly c ... | 2005 | 15757424 |
| the plasmids of chlamydia trachomatis and chlamydophila pneumoniae (n16): accurate determination of copy number and the paradoxical effect of plasmid-curing agents. | a 7.5 kbp cryptic plasmid is found in almost all isolates of chlamydia trachomatis. real-time pcr assays, using taqman chemistry, were set up to quantify accurately both the chlamydial plasmid and the single copy, chromosomal omcb gene in the infectious, elementary bodies (ebs) of c. trachomatis l1 440. plasmid copy number was also determined in the ebs of six other lymphogranuloma venereum (lgv) isolates (serovars l1-l3), ten trachoma isolates (serovars a-c) and nine urogenital isolates (serova ... | 2005 | 15758234 |
| interaction of microbiology and pathology in women undergoing investigations for infertility. | cases of endometriosis with no tubal damage are associated with infertility, suggesting an immunological rather than mechanical barrier to reproduction. laparoscopy and falloposcopy results of clinically asymptomatic women undergoing investigation of infertility were correlated with the outcomes of microbiological screening for chlamydia trachomatis, mycoplasma pneumoniae, mycoplasma hominis, ureaplasma species, neisseria gonorrhoeae, neisseria meningitidis and chlamydia pneumoniae. | 2004 | 15763913 |
| intermittent azithromycin treatment for respiratory symptoms in patients with chronic chlamydia pneumoniae infection. | chlamydia pneumoniae (cpn) is a common respiratory pathogen with a biphasic replicative cycle and has a tendency to cause chronic infections. azithromycin is commonly used for the treatment of cpn infections, but little is known about the optimal dose and duration of therapy. in this prospective double-blind, randomized study the effects of azithromycin and placebo were compared regarding longstanding airway and/or pharyngeal symptoms in patients with chronic cpn infection. further, effects on a ... | 2004 | 15764166 |
| community-acquired pneumonia in japan: a prospective ambulatory and hospitalized patient study. | in this study the aetiology of community-acquired pneumonia (cap) in japan was investigated and the incidence of causative pathogens in ambulatory and hospitalized patients was compared. in addition, the roles of chlamydophila felis and chlamydophila pecorum as causes of cap were investigated. five hundred and six patients with cap who visited an outpatient clinic or were admitted to one of three different hospitals were enrolled in this study; 106 of them were outpatients and 400 were hospitali ... | 2005 | 15770027 |
| [part of chlamydia pneumoniae in atherosclerosis and exacerbation of chronic obstructive pulmonary disease and asthma]. | chlamydia pneumoniae infection has been often associated with several chronic diseases including asthma and chronic obstructive pulmonary diseases (copd). the spectrum of chlamydia pneumoniae infection has been expanded to the association with coronary heart disease (chd). in morocco, the implication of chlamydia pneumoniae infection in these pathologies is unknown. the aim of our study was to determine the relationship between infection with chlamydia pneumoniae and respiratory pathology and at ... | 2005 | 15771975 |
| matrix metalloproteinase-9 expression is associated with the presence of chlamydia pneumoniae in human coronary atherosclerotic plaques. | to investigate the association between chlamydia pneumoniae and matrix metalloproteinase-9 (mmp-9) in atherosclerotic plaques. | 2005 | 15772219 |
| [detection of mycoplasma pneumoniae and chlamydophila pneumoniae in patients with community acquired pneumonia]. | a total of 292 patients with pneumonia confirmed by clinical, roentgenological and laboratory methods, admitted to the hospital from closed communities during the one year period, were examined. the sputa of patients with pneumonia in the acute stage were studied in the polymerase chain reaction (pcr). the predominence of m. pneumoniae and c. pneumoniae causualties in autumn and winter period was established. the monitoring of atypical infective agents with the use of the pcr techniques gives ev ... | 2005 | 15773404 |
| [the immune system, atherosclerosis and persisting infection]. | the paper demonstrates that lymph nodes situated in the vicinity of magistral blood vessels are the source of immune and inflammatory response to ldl as the main pathogenetic factor in atherosclerosis. the activation of t-cell-mediated immunity takes place in them at the very early stages of the disease, resulting in forming of cd4+t-lymphocytes, activated mononuclear cells and immunostabilizing b-lymphocytes. the cell changes in lymph nodes correlate with the severity of atherosclerotic lesions ... | 2005 | 15776961 |
| contact of chlamydophila pneumoniae with type ii cell triggers activation of calcium-mediated nf-kappa b pathway. | nuclear factor-kappa b (nf-kappa b) plays an important role in inflammation, proliferation and regulation of apoptosis. the purpose of the present study on type ii cells was to investigate whether chlamydophila pneumoniae contact induces (i) a ca2+ release, that (ii) disrupts f-actin/beta-tubulin cytoskeletal association with nf-kappa b/i kappa b alpha, leading to (iii) a subsequent nf-kappa b activation. incubation of rat type ii pneumocytes with c. pneumoniae caused an intracellular calcium re ... | 2005 | 15777838 |
| effect of chlamydia pneumoniae infection and hyperlipidaemia on the expression of ppargamma, p50 and c-fos in aortic endothelial cells in c57bl/6j mice. | to investigate the effect of c. pneumoniae infection and/or hyperlipidaemia on the expression of peroxisome proliferator-activated receptor gamma (ppargamma), nuclear factor-kappa b (nf-kappab) and activated protein-1 (ap-1) in aortic endothelial cells in c57bl/6j mice. | 2005 | 15779851 |
| can worms defend our hearts? chronic helminthic infections may attenuate the development of cardiovascular diseases. | the established risk factors for atherosclerosis fail to fully explain the extent and severity of coronary artery diseases in 50% of the patients. thus, the causative agents and processes, which may be involved in the pathogenesis of atherosclerosis, are being sought. notoriously, atherosclerosis and cardiovascular event rates are much lower in developing countries. clinically, severe infections by intracellular pathogens are widespread mostly in developing countries with poor sanitation, nutrit ... | 2005 | 15780483 |
| atherosclerosis -- an infectious disease? | | 2005 | 15780516 |
| chlamydophila pneumoniae antibodies in office workers with and without inflammatory rheumatic diseases in a moisture-damaged building. | | 2005 | 15782279 |
| chlamydial infection induces pathobiotype-specific protein tyrosine phosphorylation in epithelial cells. | members of the genus chlamydia are strict obligate intracellular pathogens that exhibit marked differences in host range and tissue tropism despite sharing a remarkable level of genomic synteny. these pathobiotype differences among chlamydiae are also mirrored in their early interactions with cultured mammalian host cells. chlamydial attachment and entry is known to trigger protein tyrosine phosphorylation. in this study, we examined the kinetics and pattern of protein tyrosine phosphorylation i ... | 2005 | 15784533 |
| chlamydia pneumoniae infected macrophages exhibit enhanced plasma membrane fluidity and show increased adherence to endothelial cells. | chlamydia pneumoniae, an intracellular prokaryote, is known to have requirement for some lipids which it is incapable of synthesizing, and these lipids have important fluidizing roles in plasma membrane. we decided to examine if the trafficking of these lipids to c. pneumoniae alters the physicochemical properties of macrophage plasma membrane, affects the expression of genes and proteins of enzymes associated with metabolism of some of these lipids and assess if ca2+ signaling usually induced i ... | 2005 | 15786718 |
| inverse association between chlamydia pneumoniae respiratory tract infection and initiation of asthma or allergic rhinitis in children. | to evaluate the role of chlamydia pneumoniae respiratory tract infection on pediatric asthma, allergic rhinitis or atopic eczema initiation, children of three age groups (n=1211) were prospectively studied for a c. pneumoniae infection using throat swabs and polymerase chain reaction (pcr) with enzyme immunoassay (eia) detection. infected children (study group, sg) were examined monthly until the agent could not be detected, quantifying persistent infection. they were compared with randomly sele ... | 2005 | 15787871 |
| why chlamydia pneumoniae is associated with asthma and other chronic conditions? suggestions from a survey in unselected 9 yr old schoolchildren. | despite numerous studies demonstrating an association between asthma and many other chronic conditions and signs of chlamydia pneumoniae (cp) infection, the role of cp in the pathogenesis of these illness remain still unclear. we investigated the prevalence of cp antigen in the upper airways and the prevalence of detectable cp serum antibodies in an unselected population of 207 9-yr-old schoolchildren. we also sought the presence of asthma, chronic or recurrent respiratory symptoms by means of q ... | 2005 | 15787872 |
| association between chlamydia pneumoniae and acute myocardial infarction in young men in the united states military: the importance of timing of exposure measurement. | several investigators have found that chlamydia pneumoniae and cytomegalovirus infections may be risk factors for coronary heart disease. however, the data remain controversial. to address this hypothesis, data and specimens were collected from a well-established prospective cohort of active-duty personnel from the us military. | 2005 | 15791511 |
| chlamydia pneumoniae and atherosclerosis. | | 2005 | 15791512 |
| cd8+ t cells specific for a potential hla-a*0201 epitope from chlamydophila pneumoniae are present in the pbmcs from infected patients. | infection with the common pathogen chlamydophila pneumoniae (cpn, previously chlamydia pneumoniae) has a high prevalence in patients suffering from arteriosclerosis and may trigger or contribute to heart disease. in mice, cd8-positive t cells are critical for the eradication of the infection and the development of immune memory against cpn. although several h2-class i epitopes have been described, no hla-class i-associated peptides from cpn are known. in order to define hla-a*0201 epitopes from ... | 2005 | 15802306 |
| immunocomb chlamydia bivalent assay to study chlamydia species-specific antibodies in patients with coronary heart disease. | serological evidences suggested an association between chlamydia pneumoniae infection and coronary heart disease (chd). efficacy of available serological tests for detection of c. pneumoniae antibody has been debated. the present study was carried-out to assess the efficacy of immunocomb chlamydia bivalent igg assay vis-à-vis micro immunofluorescence (mif) test in detecting c. pneumoniae and c. trachomatis--specific antibodies in patients with chd. | 2005 | 15802759 |
| [pcr-based diagnostics of community-acquired pneumonia of mycoplasmal and chlamydia etiologies]. | two hundred and ninety-two patients with pneumonia evidenced by clinical, x-ray and laboratory findings were examined for the purpose of studying the etiological significance of mycoplasma pneumoniae and chlamydophila pneumoniae--atypical pathogens; the patients, members of closed bodies, were admitted to the hospital for as long as one year. pcr was used to examine the sputum of patients who were at exacerbation. it was established that the mentioned pathogens prevailed in autumn and winter. it ... | 2005 | 15804102 |
| immunological factors in the pathogenesis and treatment of age-related macular degeneration. | recent findings indicate that immunological factors are involved not only in the pathogenesis of age-related macular degeneration (amd), but also in its treatment. earlier data showing the presence of inflammatory cells in affected areas of amd retinas support this statement. although a possible role for autoimmunity was initially suggested, it has never reached general acceptance. microorganisms have also been implied in the pathogenesis of amd. both serum antibacterial antibody levels and posi ... | 2005 | 15804763 |
| [the role of infection in the pathogenesis of atherosclerosis]. | experimental models and human studies have supported a role of infection in the initiation of atherosclerosis. there are many known microorganisms who can play an important role in atherosclerosis, but especially two of them--chlamydia pneumoniae and cytomegalovirus are suspected to stimulate the process of atheromatosis. until antibiotics or vaccines are useful in artery diseases prevention, therapies with proven vascular anti-inflammatory effects (diet, exercise, smoking cessation, aspirin, st ... | 2004 | 15810509 |
| lack of serum oligoclonal antibody responses to chlamydophila pneumoniae in multiple sclerosis. | chlamydophila pneumoniae has been proposed as an aetiological agent in ms via a mechanism involving molecular mimicry. we undertook to investigate whether the presence of csf oligoclonal igg ocb or oligoclonal bands correlated with serum igg raised against c. pneumoniae. paired serum and csf of 19 ms patients and 27 control patients with other neurological diseases were studied by ief and western blotting. only 1 of 19 ms patients had serum antibodies against c. pneumoniae compared with 2 of the ... | 2005 | 15812167 |
| polymorphonuclear neutrophils improve replication of chlamydia pneumoniae in vivo upon myd88-dependent attraction. | chlamydia pneumoniae, an obligate intracellular bacterium, causes pneumonia in humans and mice. in this study, we show that gr1+/cd45+ polymorphonuclear neutrophils (pmn) surprisingly increase the bacterial load of c. pneumoniae in vivo. upon intranasal infection of wild-type mice, the lung weight is increased; the cytokines tnf, il-12p40, and ifn-gamma, as well as the chemokines keratinocyte-derived chemokine, mcp-1, and mip-2 are secreted; and gr1+/cd45+ pmn are recruited into lungs 3 days pos ... | 2005 | 15814710 |
| high prevalence of chlamydia pneumoniae antibodies and increased high-sensitive c-reactive protein in patients with vascular dementia. | to determine the relationships between chlamydia pneumoniae infection, carotid atherosclerosis, and dyslipidemia in patients with vascular dementia (vad) and alzheimer's disease (ad). | 2005 | 15817002 |
| community-acquired pneumonia in children. | this review highlights recent developments in the diagnosis, etiology, therapy, and prevention of community-acquired pneumonia in children. | 2005 | 15818183 |
| pneumonia in the elderly (geriatric) population. | review of recent studies (2003 and 2004) concerning pneumonia in the very old. | 2005 | 15818184 |
| overexpression of mmp9 and tissue factor in unstable carotid plaques associated with chlamydia pneumoniae, inflammation, and apoptosis. | tissue remodeling by matrix metalloproteinases (mmps) and plasminogen activators such as tissue factor (tf) is postulated to be involved in the pathogenesis of atherosclerosis. the in situ expression of mmp9 and tf in unstable atherosclerotic plaques has not been examined in detail. moreover, interference of tissue remodeling by vascular inflammation, apoptosis, and chlamydia pneumoniae inside plaque subregions is unclear. a total of 40 autopsy carotid arteries (controls) and 20 atherosclerotic ... | 2005 | 15818457 |
| the latest from the ivd industry december 2004. chlamydia--pathogens that are still often underestimated. | chlamydiae are bacteria living as intracellular parasites. contemporary differentiation distinguishes nine species, of which three are relevant to human medicine. infections with chlamydia trachomatis are among the most widespread sexually transmitted diseases. chlamydophila pneumoniae invade the respiratory tract, chlamydophila psittaci is the pathogen of ornithosis. chlamydial infections frequently progress asymptomatically and hence remain untreated. serious chronic secondary diseases are the ... | 2005 | 15819175 |
| chlamydia pneumoniae and lung cancer: epidemiologic evidence. | chlamydia pneumoniae is a common cause of acute respiratory infection and has been hypothesized to cause several chronic diseases, including lung cancer. the purpose of this article is to identify, describe, and critically examine the published studies on the association between c. pneumoniae infection and risk of lung cancer. in the six studies identified, previous c. pneumoniae infection was defined on the basis of serologic criteria, which varied between studies. all studies reported elevated ... | 2005 | 15824142 |
| chlamydia pneumoniae infection is an unlikely cause of primary biliary cirrhosis. | | 2005 | 15826729 |
| seroprevalence of mycoplasma pneumoniae and chlamydia pneumoniae in stable asthma and chronic obstructive pulmonary disease. | mycoplasma pneumoniae and chlamydia pneumoniae have been suggested to take part in the acute exacerbation of bronchial asthma and chronic obstructive pulmonary disease (copd). several studies have questioned whether they may play pathogenic roles in connection with bronchial asthma and copd. this study was designed to evaluate the seroprevalences of m. pneumoniae and c. pneumoniae in stable asthma and copd patients, and to compare with control patients. the medical records of one hundred forty p ... | 2005 | 15831991 |
| inflammatory abdominal aortic aneurysm and chlamydia pneumoniae infection. | | 2005 | 15837101 |
| association of helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects. | the goal of the present study was to determine whether seropositivity to helicobacter pylori (hp), chlamydia pneumoniae (cp), and cytomegalovirus (cmv) is associated with systemic inflammation and endothelial dysfunction in healthy male subjects. | 2005 | 15837252 |
| the chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation. | the obligate intracellular bacterial pathogen chlamydophila abortus strain s26/3 (formerly the abortion subtype of chlamydia psittaci) is an important cause of late gestation abortions in ruminants and pigs. furthermore, although relatively rare, zoonotic infection can result in acute illness and miscarriage in pregnant women. the complete genome sequence was determined and shows a high level of conservation in both sequence and overall gene content in comparison to other chlamydiaceae. the 1,14 ... | 2005 | 15837807 |
| an asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumonia. | in many parts of asia, the inaccessibility and high cost of diagnostic tests have hampered the study of community-acquired pneumonia (cap) caused by atypical respiratory pathogens. | 2004 | 15840455 |
| helicobacter pylori infection and ischaemic heart disease: an overview of the general literature. | in the last years, a considerable number of studies have been performed on the correlation between helicobacter pylori infection and ischaemic heart disease. the reason is the supposed role of some chronic infections in the genesis and development of vessel wall injury and atheromatous plaque, as already reported for chlamydia pneumoniae and herpes viruses. while this association may be theoretically conceivable, it still remains debated from a practical point of view. epidemiological and animal ... | 2005 | 15843077 |
| a cd8+ t cell heptaepitope minigene vaccine induces protective immunity against chlamydia pneumoniae. | an intact t cell compartment and ifn-gamma signaling are required for protective immunity against chlamydia. in the mouse model of chlamydia pneumoniae (cpn) infection, this immunity is critically dependent on cd8(+) t cells. recently we reported that cpn-infected mice generate an mhc class i-restricted cd8(+) tc1 response against various cpn ags, and that cd8(+) ctl to multiple epitopes inhibit cpn growth in vitro. here, we engineered a dna minigene encoding seven h-2(b)-restricted cpn ctl epit ... | 2005 | 15843575 |
| azithromycin for the secondary prevention of coronary events. | epidemiologic, laboratory, animal, and clinical studies suggest that there is an association between chlamydia pneumoniae infection and atherogenesis. we evaluated the efficacy of one year of azithromycin treatment for the secondary prevention of coronary events. | 2005 | 15843666 |
| antibiotic treatment of chlamydia pneumoniae after acute coronary syndrome. | chlamydia pneumoniae has been found within atherosclerotic plaques, and elevated titers of antibody to this organism have been linked to a higher risk of coronary events. pilot studies have suggested that antibiotic treatment may reduce the risk of cardiovascular events. | 2005 | 15843667 |
| infection, antibiotics, and atherothrombosis--end of the road or new beginnings? | | 2005 | 15843674 |
| tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by chlamydia pneumoniae in mice. | the role of tumor necrosis factor alpha (tnf-alpha) in chlamydia pneumoniae atherogenesis was evaluated in tnf-alpha p55 receptor-deficient c57bl/6j mice fed a high-fat/high-cholesterol diet. no acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that tnf-alpha plays a role in the acceleration of atherosclerosis by c. pneumoniae. | 2005 | 15845526 |
| a 6 week course of azithromycin treatment has no beneficial effect on atherosclerotic lesion development in apolipoprotein e-deficient mice chronically infected with chlamydia pneumoniae. | to evaluate whether antimicrobial chemotherapy prevents acceleration of atherosclerotic lesion development induced by infection with chlamydia pneumoniae. | 2005 | 15845780 |
| [antiphospholipid antibodies induced by chlamydia pneumoniae infections]. | | 2005 | 15847779 |
| [is there a link between chronic chlamydial infection and childhood asthma?]. | the paper explores the possible role of chronic chlamydial infection in childhood bronchial asthma. | 2004 | 15849399 |
| telithromycin: the first ketolide for the treatment of respiratory infections. | the pharmacology, mechanisms of resistance, in vitro activity, clinical efficacy, pharmacokinetics, indications, adverse effects, dosage and administration, and place in therapy of telithromycin in the treatment of respiratory infections are reviewed. | 2005 | 15851496 |
| growth cycle-dependent pharmacodynamics of antichlamydial drugs. | chlamydiae are obligate intracellular pathogens that exhibit an extensive intracellular developmental cycle in vivo. clinical treatment of chlamydial infection is typically initiated upon occurrence of symptomatology and is directed against an asynchronous population of different chlamydial developmental forms. pharmacodynamics of antichlamydial drugs are predominantly characterized by mics; however, in vitro determinations of mic may not reflect differential susceptibilities of the developmenta ... | 2005 | 15855506 |
| lack of association between chlamydia pneumoniae serology and endothelial dysfunction of coronary arteries. | recent publications brought up the hypothesis that an infection with chlamydia pneumoniae (cp) might be a major cause of coronary artery disease (cad). therefore, we investigated whether endothelial dysfunction (ed) as a precursor of atherosclerosis might be detectable in patients with previous infection with cp but without angiographic evidence of cad. | 2005 | 15857519 |
| [role of inflammation and infection in the etiopathogenesis of atheromatosis--literature review]. | the investigation of etiopathology of arteriosclerosis shows close relationship between inflammatory processes and evolution of sclerotic lesions. in many patients acute coronary syndromes are caused by the rupture of hemodynamically insignificant sclerotic lesion and consequently thrombosis of coronary artery. the reason of instability of sclerotic plaque may be on going inflammation inside it. this paper reviews literature on the subject of relationship of atheromatosis, inflammation and infec ... | 2004 | 15865245 |
| chlamydia pneumoniae arthritis in a patient with common variable immunodeficiency. | arthritis is an important and sometimes life-threatening complication in patients with common variable immunodeficiency (cvid). | 2005 | 15875533 |
| discordant detection of chlamydia pneumoniae in patients with carotid artery disease using polymerase chain reaction, immunofluorescence microscopy and serological methods. | to determine the presence of chlamydia pneumoniae in carotid plaque and peripheral blood mononuclear cells (pbmcs) using a combination of serology, direct antigen detection by immunofluorescence (if) microscopy and polymerase chain reaction (pcr), and to compare the results obtained from each assay. | 2005 | 15875737 |
| role of atypical bacteria and azithromycin therapy for children with recurrent respiratory tract infections. | the aim of this study of 352 patients, 1-14 years of age, with acute respiratory infections and a history of recurrent respiratory tract infections (rrtis), and 208 healthy subjects was to evaluate whether mycoplasma pneumoniae and chlamydia pneumoniae played a role in causing acute respiratory episodes among children with rrtis and whether specific antibiotic treatment for these bacteria could improve the acute episodes and reduce recurrences. | 2005 | 15876944 |
| chlamydia pneumoniae and mycoplasma pneumoniae in young children from china with community-acquired pneumonia. | eighty-five cases community-acquired pneumonia (cap) in children 5 years or younger, confirmed by chest x-ray, and 185 age-matched control patients with diarrhea or dermatitis from the outpatient department at beijing children's hospital were enrolled into this study. nasopharyngeal swab specimens were obtained from all subjects. real-time pcr-based fluorescence assays were performed for chlamydia pneumoniae and mycoplasma pneumoniae. a nested pcr was also run for c. pneumoniae for comparison of ... | 2005 | 15878436 |
| recombinant human alphaa-crystallin can protect the enzymatic activity of cpudg against thermal inactivation. | alpha-crystallin is one of the major protein components in mammalian lens fiber cells. it is composed of alphaa and alphab subunits that have structural homology to the family of mammalian small heat shock proteins. horwitz firstly characterized native alpha-crystallin as a molecular chaperone in vitro based on its ability to prevent heat-induced aggregation of lens proteins and enzymes. andley et al. cloned and expressed human alphaa-crystallin in escherichia coli and confirmed its chaperone ac ... | 2005 | 15878551 |
| association of uterine and salpingeal fibrosis with chlamydial hsp60 and hsp10 antigen-specific antibodies in chlamydia-infected koalas. | infection by chlamydia pneumoniae or chlamydia pecorum commonly causes chronic, fibrotic disease of the urogenital tracts of female koalas. studies of humans have associated titers of serum immunoglobulin g (igg) against chlamydial hsp60 and hsp10 antigens with chronic infection, salpingeal fibrosis, and tubal infertility. to determine whether a similar relationship exists in chlamydia-infected koalas, samples were collected opportunistically from 34 wild female koalas and examined by gross path ... | 2005 | 15879024 |
| prevalence and persistence of chlamydia pneumoniae antibodies in healthy laboratory personnel in finland. | the rates of chlamydia pneumoniae seroconversions suggesting acute primary infections or reinfections and the prevalences of antibodies were followed up among healthy laboratory workers. annual serum samples were collected from 47 persons in helsinki from 1958 to 1990 and from 40 persons in oulu from 1994 to 1999. c. pneumoniae species-specific immunoglobulin g (igg), iga, and igm antibodies were measured by microimmunofluorescence (mif) in 407 sera from helsinki. the 185 sera collected in oulu ... | 2005 | 15879028 |
| human 60-kda heat shock protein is a target autoantigen of t cells derived from atherosclerotic plaques. | epidemiological studies suggest the potential importance of an inflammatory component in atherosclerosis and support the hypothesis that immune responses to ags of pathogens cross-react with homologous host proteins due to molecular mimicry. protein candidates involved may be the stress-induced proteins known as heat shock proteins (hsp). in this study, we report that atherosclerotic plaques harbor in vivo-activated cd4(+) t cells that recognize the human 60-kda hsp. such in vivo-activated 60-kd ... | 2005 | 15879154 |
| effects of fluoroquinolones on the migration of human phagocytes through chlamydia pneumoniae-infected and tumor necrosis factor alpha-stimulated endothelial cells. | | 2005 | 15879798 |
| cytokine response of lymphocytes persistently infected with chlamydia pneumoniae. | chlamydia pneumoniae infection of lymphocytes in blood has been documented, and it is apparent that control of this pathogen in lymphocytes as well as immune functions of the infected lymphocytes may be critical in the development of chronic inflammatory diseases associated with infection by this bacterium. since immune function of lymphocytes infected with c. pneumoniae has not been well studied, the cytokine response of lymphocytes infected with this pathogen was analyzed using an in vitro inf ... | 2005 | 15883875 |
| comparative cell signalling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotes. | heat-shock protein (hsp)60/chaperonin 60 is a potent immunogen which has recently been claimed to have cell-signalling actions upon myeloid and vascular endothelial cells. the literature is controversial with different chaperonin 60 proteins producing different patterns of cellular activation and the ever-present criticism that activity is the result of bacterial contaminants. to clarify the situation we have cloned, expressed and purified to homogeneity the chaperonin 60 proteins from chlamydia ... | 2005 | 15885129 |
| steady-state serum and intrapulmonary pharmacokinetics and pharmacodynamics of tigecycline. | the steady-state serum and intrapulmonary pharmacokinetic and pharmacodynamic parameters of tigecycline were determined after intravenous administration in 30 subjects. tigecycline was administered as a 100mg loading dose followed by six 50mg doses given every 12h and was measured using hplc/mass spectrometry. ratios of tigecycline maximum serum concentration and area under the serum concentration-time curve to 90%-minimum inhibitory concentrations (c(max)/mic(90); auc/mic(90)), and percentage t ... | 2005 | 15885987 |
| secretion of cpn0796 from chlamydia pneumoniae into the host cell cytoplasm by an autotransporter mechanism. | by comparison of proteome profiles of purified chlamydia pneumoniae and whole lysates of c. pneumoniae infected hep-2 cells, an n-terminal fragment of the previously uncharacterized chlamydial protein cpn0796 was identified as a secreted protein. a 38 kda cleavage product of cpn0796 was present in infected cells, whereas only the 65 kda full-length cpn0796 could be detected in purified chlamydia. confocal immunofluorescence microscopy demonstrated that cpn0796 was localized in the chlamydia memb ... | 2005 | 15888085 |
| management of nonsevere pneumonia in military trainees with the urinary antigen test for streptococcus pneumoniae: an innovative approach to targeted therapy. | the drug of choice for treatment of streptococcus pneumoniae infection is generally a penicillin (including amoxicillin). targeted therapy is, however, rarely used, because results of definitive diagnostic tests for pneumonia are not available for several days. thus, broad-spectrum antibiotics are used for empirical treatment of pneumonia to cover both typical and atypical pathogens. our purpose was to assess the usefulness of a strategy of targeted antimicrobial therapy based on the results of ... | 2005 | 15889358 |
| telithromycin: a ketolide antibiotic for treatment of respiratory tract infections. | telithromycin, a recently approved ketolide antibiotic derived from 14-membered macrolides, is active against erythromycin-resistant pneumococci. telithromycin has enhanced activity in vitro because it binds not only to domain v of ribosomal rna (like macrolides do) but also to domain ii. however, it is not active against streptococci and staphylococci with constitutive macrolide, lincosamide, and streptogramin b resistance. telithromycin, available in an oral formulation, is approved by the us ... | 2005 | 15889365 |
| identification of chlamydia pneumoniae in intracranial and extracranial arteries in patients with stroke and in controls: combined immunohistochemical and polymerase chain reaction analyses. | an association of the obligatory intracellular gram-negative pathogen chlamydia pneumoniae with coronary artery disease, myocardial infarction, and atherosclerosis was suggested. the presence of c pneumoniae was determined in different arteries (n = 165) from 23 control cases and 10 patients with stroke including coronary arteries, carotid arteries, basilar artery, and middle cerebral arteries of normal controls and patients with stroke using nested polymerase chain reaction (pcr) and immunohist ... | 2005 | 15892001 |
| [chlamydial pathogenesis: diagnostic and therapeutic consequences]. | chlamydiae are among the most common of the human pathogens. clinical persistence is a key concept in chlamydial pathogenesis. the damaging disease sequelae such as sterility caused by chlamydia trachomatis and coronary artery disease associated with chlamydia pneumoniae, are caused by inflammation-based pathology. although chlamydiacidal antibiotics may kill the bacteria, chlamydial antigens may persist for prolonged period and there is evidence that these non-cultivable forms may lead to conti ... | 2005 | 15893234 |
| [chlamydiae infections: diagnostic procedures]. | the objective of this review is to critically describe the diagnostic procedures for chlamydiae infections. direct identification in culture remains fastidious and lacks sensitivity. antigen detection techniques include direct immunofluorescence using monoclonal antibodies and immunohistochemistry. until recently, serologic testing was commonly used for the diagnosis, but sensitivity was low for acute infections. the situation has been greatly improved by the advent of molecular techniques allow ... | 2005 | 15893237 |
| [antibiotherapy in children with atypical bacterial infections]. | atypical bacteria responsible for infections in children are mainly mycoplasma pneumoniae, chlamydia pneumoniae and legionella pneumophila. atypical pneumonia is a frequent disease in children. until recently, the outcome was thought to be rather benign and antibiotherapy to have only a minor impact on the prognosis. recent studies have demonstrated that m. pneumoniae and c. pneumoniae were involved in a variety of infections, including acute upper airway disease, otitis and pharyngitis under fi ... | 2005 | 15893238 |
| low prevalence of antibodies against heat shock protein 10 of chlamydophila pneumoniae in patients with coronary heart disease. | in this study the prevalence of antibodies against the heat shock protein 10 (hsp10) of chamydophila pneumoniae (cp) (as assessed by elisa) in patients with coronary heart disease (chd) and seropositive or seronegative to cp, as assessed by microimmunofluorescence (mif), was investigated. the controls were age- and sex-matched healthy subjects. the hsp10 preparation used throughout this study was a 6-his-tagged recombinant protein preliminarily shown to be immunogenic in mice. low level igg reac ... | 2005 | 15893396 |
| stent implantation, but not pathogen burden, is associated with plasma c-reactive protein and interleukin-6 levels after percutaneous coronary intervention in patients with stable angina pectoris. | the systemic inflammatory response to percutaneous coronary intervention (pci) is associated with recurrent cardiac events; however, the pathophysiology of this inflammatory response is not well understood. the present study was performed to investigate the role of pathogen burden of infection in determining the magnitude of c-reactive protein (crp) and interleukin 6 (il-6) response to pci. | 2005 | 15894971 |
| [chlamydia: diagnostic and treatment]. | chlamydia are obligate intracellular bacteria. three species are considered human pathogens. chlamydophila pneumoniae is one of the most common agents of atypical community-acquired pneumonia. chlamydophila psittaci causes psittacosis, a severe zoonotic pneumonia transmitted by birds. finally, chlamydia trachomatis is the etiologic agent of trachoma and urogenital infections. the latter are commonly asymptomatic or paucisymptomatic. thus, they may remain undiagnosed for years, leading to serious ... | 2005 | 15895932 |
| [previous infection with chlamydia pneumoniae and long-term prognosis in patients with acute coronary syndrome with non-st segment elevation]. | contradictory data exists from case-control studies and in patients with stable coronary artery disease on the association of prior exposure to chlamydia pneumoniae and cardiovascular events. we underwent a prospective study to investigate the prognostic value of c. pneumoniae seropositivity in patients with acute coronary syndromes. | 2005 | 15899161 |
| association between angiographic evidence of coronary artery disease and seropositivity for helicobacter pylori and chlamydia pneumoniae infection. | | 2005 | 15900388 |
| exposure to chlamydia pneumoniae infection and progression of age-related macular degeneration. | recent studies have found an association between exposure to chlamydia pneumoniae infection and risk of age-related macular degeneration (amd). to assess a potential risk of amd progression posed by exposure to c. pneumoniae, the authors reexamined australian residents in 2001-2002 who were aged 51-89 years with early amd at baseline (1992-1995). examination included macular photography and an enzyme-linked immunosorbent assay to determine antibody titers to the elementary bodies from c. pneumon ... | 2005 | 15901621 |
| ectasia and severe atherosclerosis: relationships with chlamydia pneumoniae, helicobacterpylori, and inflammatory markers. | to date, there has been no convincing evidence for an association between chlamydia pneumoniae or helicobacter pylori and ectasia. in this case-control study, we have investigated the association of h. pylori and c. pneumoniae seropositivity with ectasia, severe coronary atherosclerosis, and normal vessels, which were so classified by coronary angiography. we have also evaluated the influence of these infections on inflammatory markers such as high-sensitive c-reactive protein (hscrp) and interl ... | 2005 | 15902817 |
| chlamydia pneumoniae infection as a trigger for a cogan's syndrome. | cogan's syndrome is often preceded by upper respiratory tract symptoms. the only reported specific agent possibly involved in pathogenesis of the cogan's syndrome was chlamydia pneumoniae. positive iga, igm and igg antibodies against c. pneumoniae in our patient suggest possibility of chlamydia's role as a trigger for the vasculitis. | 2006 | 15904966 |
| association of hla-drb3*0202 and serum igg antibodies to chlamydia pneumoniae with essential hypertension in a highly homogeneous population from majorca (balearic islands, spain). | separate studies investigating the relationship of essential hypertension (eh) with the hla system and with chlamydia pneumoniae (c. pneumoniae) infection have given conflicting results. our aim was to clarify these relationships and determine whether the hla system and c. pneumoniae infection interact with respect to the risk for eh. an association study (110 essential hypertensives and 107 controls) was conducted in a highly homogeneous population in the balearic island of majorca (spain). mol ... | 2005 | 15905891 |
| prevalence and clinical features of chlamydia pneumoniae pneumonia at srinagarind hospital, khon kaen, thailand. | between october 2000 and december 2002, a prospective study was conducted among hospitalized community acquired pneumonia (cap) patients admitted to srinagarind hospital, khon kaen, thailand. the diagnosis of chlamydia pneumoniae infection was based on serologic testing. the prevalence of c. pneumoniae among patients hospitalized with cap was 8.7%; 24 cases of 276 hospitalized cap patients. the mean age was 42.7 (range, 17-79) years and the male to female ratio was 1:2.4. more than half (54.2%) ... | 2005 | 15906659 |
| etiologies and treatment outcomes in patients hospitalized with community-acquired pneumonia (cap) at srinagarind hospital, khon kaen, thailand. | local epidemiological data on the etiologies of in-patients who are hospitalized with cap is needed to develop guidelines for clinical practice. this study was conducted to determine the pattern of microorganisms causing community-acquired pneumonia (cap) in adult patients admitted to srinagarind hospital, khon kaen, thailand, between january 2001 and december 2002. altogether, 254 patients (124 males, 130 females) averaging 56.4 (sd 19.8) years were included. eighty-six of them (33.8%) presente ... | 2005 | 15906660 |
| identification of chlamydia pneumoniae within human choroidal neovascular membranes secondary to age-related macular degeneration. | age-related macular degeneration (amd) is a leading cause of blindness in the united states, and increasing evidence suggests that it is an inflammatory disease. the prokaryotic obligate intracellular pathogen chlamydia pneumoniae is emerging as a novel risk factor in cardiovascular disease, and recent sero-epidemiological data suggest that c. pneumoniae infection is also associated with amd. in this study, we examined choroidal neovascular membrane (cnv) tissue from patients with neovascular am ... | 2005 | 15909160 |
| periodontitis in cardiology--a clinical perspective. | the association between ischemic cardiovascular disease and infectious disease is very dubious, and evidence points in several directions. chronic periodontitis has been proposed as a potential risk factor based on many studies. a review of these studies demonstrates that the majority of them are retrospective epidemiological studies and therefore of little value in determining a possible association. new data seems to indicate an association between atherosclerosis and alveolar bone loss, thus ... | 2005 | 15912924 |
| a directed screen for chlamydial proteins secreted by a type iii mechanism identifies a translocated protein and numerous other new candidates. | chlamydiae are strict intracellular parasites that induce their internalization upon contact with the host cell and grow inside an intracellular compartment called an inclusion. they possess a type iii secretion (tts) apparatus, which allows for the translocation of specific proteins in the host cell cytosol. in particular, chlamydial proteins of the inc family are secreted to the inclusion membrane by a tts mechanism; other tts substrates are mostly unknown. using a secretion assay based on the ... | 2005 | 15916612 |
| a population based seroepidemiological survey of chlamydia pneumoniae infections in schoolchildren. | a serosurvey was carried out in schoolchildren from a northeastern area of italy to define the burden of chlamydia pneumoniae infection. | 2005 | 15917413 |
| density of chlamydia pneumoniae is increased in fibrotic and calcified areas of degenerative aortic stenosis. | the process of aortic degeneration associated with calcified aortic stenosis shares many similarities with coronary artery atherosclerosis. inflammation and infection are involved in both diseases. chlamydia pneumoniae has been identified in atherosclerotic plaques. however, the studies about the presence of c. pneumoniae in degenerative aortic stenotic valves are not conclusive. | 2006 | 15925417 |
| effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials. | although chlamydia pneumoniae infection has been associated with the initiation and progression of atherosclerosis, results of clinical trials investigating antichlamydial antibiotics as adjuncts to standard therapy in patients with coronary artery disease (cad) have been inconsistent. | 2005 | 15928286 |