| functional evaluation of t helper, t suppressor, and b lymphocytes in lethally irradiated rhesus monkeys injected with autologous bone marrow. | lethally irradiated rhesus monkeys were treated with autologous bone marrow that had either been (1) nontreated, i.e., normal; (2) depleted of t lymphocytes with a monoclonal antibody directed against rhesus t lymphocytes; (3) fractionated with the soybean agglutinin (sba- fraction); or (4) fractionated with sba and further depleted of t cells by e-rosetting. there was no difference in hematologic reconstitution among the animals, but all showed a marked lowering of the t helper/t suppressor rat ... | 1992 | 1534940 |
| relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid. | increased concentrations of the excitotoxin quinolinic acid (quin) have been implicated in the neurologic deficits and brain atrophy that may accompany infection with the human immunodeficiency virus type-1. key neuropathologic features of the aids encephalitis are replicated in some macaques following infection with the simian immunodeficiency virus (siv). in the present studies, cerebrospinal fluid (csf) quin concentrations increased within 2 weeks following infection of 11 rhesus macaques (ma ... | 1992 | 1535532 |
| regional brain kinetics of 6-fluoro-(beta-11c)-l-dopa and (beta-11c)-l-dopa following comt inhibition. a study in vivo using positron emission tomography. | the regional brain kinetics of (beta-11c)-l-dopa and 6-fluoro-(beta-11c)-l-dopa was measured in six rhesus monkeys using positron emission tomography (pet). radioactivity accumulated specifically in the striatal region and the increase in l-dopa-derived radioactivity utilization with time was calculated using surrounding brain as a reference area, this being devoid of dopaminergic activity. the rate constant for selective striatal utilization i.e. grossly decarboxylation was 0.0110 +/- 0.0007 (s ... | 1992 | 1536715 |
| in vivo synergism of recombinant human interleukin-3 and recombinant human interleukin-6 on thrombopoiesis in primates. | using a primate model, we examined the effect of recombinant human interleukin-3 (rhil-3) and rhil-6 on thrombopoiesis in vivo. administration of 33 micrograms/kg/d of rhil-3 for 11 to 14 days increased levels of circulating colony-forming units megakaryocyte (cfu-mk) by approximately 15-fold in five rhesus monkeys without raising their platelet counts. in contrast, administration of 30 micrograms/kg/d of rhil-6 for 10 days in four animals did not increase cfu-mk levels but significantly raised ... | 1992 | 1536942 |
| effects of orchidectomy on gonadotropin and inhibin subunit messenger ribonucleic acids in the pituitary of the rhesus monkey (macaca mulatta). | our research programs required the preparation of hypophysectomized and orchidectomized rhesus monkeys. this afforded us the possibility to characterize and compare levels of the gonadotropin and inhibin subunit mrnas in pituitaries from intact and castrate monkeys. eighteen adult male monkeys, four of which had been bilaterally orchidectomized 5-9 months previously, were used in this study. plasma concentrations of lh and fsh were, respectively, 188.5 +/- 5.3 and 246.8 +/- 25.2 ng/ml in the cas ... | 1992 | 1537290 |
| impaired insulin secretion after intravenous glucose in neonatal rhesus monkeys that had been chronically hyperinsulinemic in utero. | chronic hyperinsulinemia in the fetal rhesus monkey results in fetal macrosomia without change in fetal plasma glucose concentration. after 18 days of hyperinsulinemia, fetuses were delivered by cesarean section, at which time experimental animals had significantly (p less than 0.05) elevated umbilical artery plasma insulin concentrations of 2039 +/- 854 pm compared with 129 +/- 72 pm. plasma immunoreactive c peptide (ircp) was significantly reduced to 39 +/- 17 pm compared with 286 +/- 134 pm. ... | 1992 | 1539035 |
| behavioral efficacy of diazepam against nerve agent exposure in rhesus monkeys. | the possibility that nerve agents will be used on the battlefield is real. the traditional therapy against nerve agent exposure consists of pyridostigmine pretreatment and atropine-pralidoxime chloride therapy administered after nerve agent exposure. this therapy regimen is extremely effective in preventing mortality in laboratory animals exposed to multilethal concentrations of nerve agent, yet these animals often display convulsions, brain damage, and behavioral incapacitation. we report here ... | 1992 | 1539066 |
| a physiologically based pharmacokinetic model for chloropentafluorobenzene in primates to be used in the evaluation of protective equipment against toxic gases. | chloropentafluorobenzene (cpfb) has been proposed as an innocuous simulant for the uptake of toxic gases. exposure to cpfb in a training exercise could be inferred afterwards from a measurement of cpfb in expired breath. to understand the relationship between exposure and measurement, we have developed a physiologically-based pharmacokinetic (pb-pk) model for cpfb in primates. to test the model, inhalation exposures were conducted on anesthetized rhesus monkeys. cpfb concentration in expired bre ... | 1992 | 1542883 |
| architecture and cortical connections of the prefrontal cortex in the rhesus monkey. | | 1992 | 1543090 |
| effect of potassium on ventilation in the rhesus monkey. | increasing the concentration of arterial plasma k+ to 6-8 mm increased ventilation in two sedated analgesic-treated rhesus monkeys who had their end-tidal co2 held constant during euoxia (arterial oxygen pressure, pa,o2, ca 100 torr) and hypoxia (pa,o2, ca 40 torr). during euoxia and hypoxia, hyperkalaemia increased ventilation up to 40 and 250%, respectively. this effect was reduced in euoxia and virtually abolished in hypoxia following an abrupt switch to 100% oxygen. thus the ventilatory resp ... | 1992 | 1543587 |
| the effects of chronic buprenorphine treatment on cocaine and food self-administration by rhesus monkeys. | the goal of this study was to determine if buprenorphine continues to reduce cocaine self-administration over long periods of treatment, or if tolerance develops to this effect. the effects of 30 to 120 days of buprenorphine treatment (0.32 mg/kg/day) on cocaine and food self-administration were examined in six rhesus monkeys. saline control treatment was studied for 15 days before and after buprenorphine treatment. intravenous cocaine (0.05 or 0.10 mg/kg) and food (1 g banana pellet) self-admin ... | 1992 | 1545386 |
| allogeneic transplantation of the radial side of the hand in the rhesus monkey: i. technical aspects. | since allogeneic transplantation of extremities can only be considered if uneventful long-term survival and functional recovery can be achieved, a series of 12 transplantations of the radial side of the hand were performed in rhesus monkeys so that these factors could be assessed. the transplant incorporated the first ray of the hand in conjunction with the radial forearm flap. graft survival times varied from 21 to 179 days. ten of 12 transplants showed rejection. in 2 of the 10, rejection coul ... | 1992 | 1546083 |
| cognitive and motor impairments associated with siv infection in rhesus monkeys. | cognitive and motor deficits are now recognized as significant clinical features of infection with the human immunodeficiency virus (hiv). juvenile rhesus macaques infected with simian immunodeficiency virus (siv) were found to exhibit cognitive and motor deficits characteristic of hiv infection. impairment on a motor skill task was the most reliable indicator of infection. various cognitive impairments were also evident. these deficits were related to siv infection of the brain but not to infla ... | 1992 | 1546323 |
| axon terminals on betz cell somata of area 4 in rhesus monkey throughout adulthood. | previous work in our laboratory demonstrated an age-related decline in the size of betz cell somata in cortical area 4 of the adult rhesus monkey brain. the present study was conducted to determine whether changes might also occur in the axon terminals upon these cortical cells. tissue from area 4 was collected from seven rhesus monkeys and prepared for electron microscopy. the ages of the monkeys ranged from 5 to 35 years, covering the entire adult life span of this species. a total of 140 betz ... | 1992 | 1546809 |
| neuropeptide y is a neuromodulator of pulsatile luteinizing hormone-releasing hormone release in the gonadectomized rhesus monkey. | in a previous study, we have demonstrated that infusion of neuropeptide y (npy) into the stalk-median eminence (s-me) of gonadectomized rhesus monkeys stimulated lhrh in a dose-dependent manner. this finding led us to address the following questions: 1) what are the characteristics of npy release in vivo? 2) how does npy release relate to lhrh release? 3) is endogenous npy essential to pulsatile lhrh release? to answer these questions, three experiments using push-pull perfusion were performed i ... | 1992 | 1547745 |
| acute lymphoid changes and ongoing immune activation in siv infection. | two features of simian immunodeficiency virus (siv) infection are emphasized: a transitory decrease in cd4 t cells in the first 2 weeks of infection followed by cd8 t-cell rise, and immune cell activation occurring by 4 weeks and persisting throughout the illness. the short-term changes included a fall in cd4 t cells by 2 weeks with partial recovery by 4 weeks and a cd8 rise that starts at 2 weeks. subsequent characterization of cd4 t cells showed reduced expression of hla-dr and cd25 (il-2 rece ... | 1992 | 1548574 |
| complex determinants of macrophage tropism in env of simian immunodeficiency virus. | macrophage-tropic virus variants evolved during the course of infection of individual rhesus monkeys with cloned, non-macrophagetropic simian immunodeficiency virus. specific changes in the envelope gene (env) were found to be primarily responsible for the dramatic increase in the ability of the virus to replicate in macrophages. cloned viruses differing at nine amino acid positions in env exhibited a more than 100-fold difference in replicative capacity for primary cultures of rhesus monkey alv ... | 1992 | 1548752 |
| novel human endogenous sequences related to human immunodeficiency virus type 1. | endogenous retrovirus-related sequences exist within the normal genomic dna of all eukaryotes, and these endogenous sequences have been shown to be important to the nature and biology of related exogenous retroviruses and may also play a role in cellular functions. to date, no endogenous sequences related to human immunodeficiency virus type 1 (hiv-1) have been reported. herein we describe the first report of the presence of nucleotide sequences related to hiv-1 in human, chimpanzee, and rhesus ... | 1992 | 1548756 |
| human immunodeficiency virus type 1 major neutralizing determinant exposed on hepatitis b surface antigen particles is highly immunogenic in primates. | hepatitis b surface antigen (hbsag) produced by recombinant dna technology is now widely and safely used worldwide for hepatitis b vaccination. we used the hbsag particle as a carrier molecule for presentation of selected human immunodeficiency virus type 1 (hiv-1) determinants to the immune system. immunization of rhesus monkeys with an hbsag chimera carrying the hiv-1 envelope major neutralizing determinant allowed us to generate proliferative t-cell responses and, in some cases, neutralizing ... | 1992 | 1548782 |
| ultrasound evaluation of fetuses of zinc-deprived monkeys (macaca mulatta). | fetal body movements were studied in three groups of gravid rhesus macaques fed different amounts of dietary zinc (100 micrograms zn/g diet, control, n = 12; 4 micrograms zn/g diet, marginal deprivation, n = 7; 2 micrograms zn/g diet, moderate deprivation, n = 11). sonographic examinations were conducted during the third trimester in awake chair-restrained dams. movement categories, derived from the human biophysical profile, were motor activity (trunk and limb movements), startle, and breathing ... | 1992 | 1550050 |
| acceleration of alveolar type ii cell differentiation in fetal rhesus monkey lung by administration of egf. | to examine the effect of epidermal growth factor (egf) on lung parenchymal maturation in fetal rhesus monkey, recombinant human egf was administered intraperitoneally (ip) at 66 mg/kg body wt over a 7-day period into the fetal peritoneal cavity alone or ip and into the amniotic fluid (af) simultaneously. the saline carrier was injected ip and af into control (co) fetuses. the body weights of the ip + af group were significantly larger than co. overall lung growth, measured as wet lung weight or ... | 1992 | 1550255 |
| resistance to collagen-induced arthritis in a nonhuman primate species maps to the major histocompatibility complex class i region. | type ii collagen-induced arthritis (cia) is an experimentally inducible autoimmune disorder that is, just like several forms of human arthritis, influenced by a genetic background. immunization of young rhesus monkeys (macaca mulatta) with type ii collagen (cii) induced cia in about 70% of the animals. one major histocompatibility complex (mhc) class i allele was present only in young animals resistant to cia and absent in arthritic animals. this strong association suggests that the mhc class i ... | 1992 | 1552289 |
| dynamic properties of medial rectus motoneurons during vergence eye movements. | 1. an early study by keller reported that medial rectus motoneurons display a step change in firing rate during accommodative vergence movements. however, a later study by mays and porter reported gradual changes in firing rate during symmetrical vergence movements. furthermore, subsequent inspection of the activity of individual medial rectus motoneurons during vergence movements indicated transient changes in their firing rate that had not been noted by mays and porter. for conjugate eye movem ... | 1992 | 1552323 |
| a comparative study of natural killer cell activity, lymphoproliferation, and cell phenotypes in nonhuman primates. | three different species of nonhuman primates (baboons [papio hamadryas], rhesus monkeys [macaca mulatta], and african green monkeys [cercopithecus aethiops]) were evaluated for their natural killer cell activity, and for the ability of their peripheral blood mononuclear cells to proliferate in response to known mitogens (concanavalin a, phytohemagglutinin, and pokeweed mitogen) and to react with a panel of mouse monoclonal antibodies directed against human leukocyte surface antigens. rhesus monk ... | 1992 | 1557864 |
| experimental studies on penetrating heterokeratoplasty with human corneal grafts in monkey eyes. | in nine rhesus monkeys, human corneal grafts were used for penetrating keratoplasty in one eye of each. the data were divided into three groups according to the size of grafts. group 1 (n = 3) received 5.5-mm human corneal grafts in 5.0-mm recipient beds; group 2 (n = 3) received 6.2-mm human corneal grafts in 6.0-mm beds; and group 3 (n = 3) received 7.5-mm grafts in 7.0-mm beds. five of nine eyes in groups 1 and 2 (55%) maintained graft clarity for more than 1 year, but only two of the three i ... | 1992 | 1559349 |
| prior binocular dissociation reduces monocular form deprivation amblyopia in monkeys. | the profound visual deficits associated with early monocular form deprivation (md) are caused largely by competitive binocular interactions in the visual cortex. we tested the hypothesis that disrupting normal cortical binocularity prior to the onset of md would reduce the degree of form deprivation amblyopia compared to that produced in animals that had normal binocular vision prior to md. an optical strabismus was maintained in two rhesus monkeys between 30 and 90 d old, a rearing strategy tha ... | 1992 | 1559780 |
| vaccine protection against sivmac infection by high- but not low-dose whole inactivated virus immunogen. | eight rhesus macaques were immunized intramuscularly four times (0, 1, 2, and 4 months) over a period of 4 months with a formalin-inactivated whole simian immunodeficiency virus (siv) vaccine in the presence of muramyl dipeptide (mdp) as adjuvant. four animals received 0.5 mg and the other four received 0.1 mg immunogen per injection. three weeks after the final immunization, the vaccinated monkeys along with two control monkeys were challenged intravenously with 50 mid50 of sivmac251-32h. at th ... | 1992 | 1560342 |
| buprenorphine's effects on self-administration of smoked cocaine base and orally delivered phencyclidine, ethanol and saccharin in rhesus monkeys. | the effects of buprenorphine on behavior reinforced by smoked cocaine base and orally delivered phencyclidine (pcp), ethanol and saccharin were compared. there were six groups of four to five rhesus monkeys. group 1 contained four monkeys that had been trained to smoke cocaine base under progressive ratio (pr) or fixed ratio (fr) schedules. up to eight smoke deliveries (2 mg/kg) were available during daily 3-hr sessions. each delivery was separated by a 15-min timeout. the remaining groups recei ... | 1992 | 1560373 |
| effects of buprenorphine and other opioid agonists and antagonists on alfentanil- and cocaine-reinforced responding in rhesus monkeys. | rhesus monkeys self-administered a range of doses of either cocaine or alfentanil under a fixed-ratio 30, time out 45 sec schedule of i.v. drug delivery. buprenorphine suppressed responding maintained by both cocaine and alfentanil; however, much larger doses of buprenorphine were required to suppress cocaine-reinforced as opposed to alfentanil-reinforced responding. neither cocaine nor alfentanil dose-effect curves were shifted to the right by buprenorphine, but were simply shifted downward. op ... | 1992 | 1560376 |
| relationship of cytochrome p450 activity to clara cell cytotoxicity. ii. comparison of stereoselectivity of naphthalene epoxidation in lung and nasal mucosa of mouse, hamster, rat and rhesus monkey. | naphthalene, a murine clara cell cytotoxicant, is metabolized by cytochrome p450 monooxygenases to unstable, chiral epoxide metabolites which can conjugate with glutathione in the presence of glutathione transferases. analysis of the three diasteriomeric glutathione adducts produced from conjugation of naphthalene oxides was used in these studies to characterize the stereochemistry of naphthalene epoxidation in preparations of nasal mucosa, lung and liver of the mouse, rat, hamster and monkey. t ... | 1992 | 1560380 |
| corpus callosum in sexually dimorphic and nondimorphic primates. | the midsagittal area and other morphological measures were taken on the corpus callosum of four different species of primate: macaca mulatta, m. fascicularis, callithrix jacchus, and saguinus oedipus. the first two species are strongly dimorphic, whereas the new world forms show little dimorphism with regard to overall body size, canines, and brain weight. neither total corpus callosal area (totalcc), or other parts of the corpus callosum (cc) showed any significant sexual dimorphism in any of t ... | 1992 | 1562061 |
| reversal of cognitive impairment by heptyl physostigmine, a long-lasting cholinesterase inhibitor, in primates. | cholinergic replacement therapy for alzheimer's disease using existing cholinesterase inhibitors is compromised by short duration, meagre benefits restricted to subgroups of patients, and peripheral toxicity. heptyl physostigmine is a lipophilic carbamate derivative of physostigmine. in rhesus monkeys, heptyl physostigmine (0.2-0.9 mg/kg i.m.) fully reversed a scopolamine-induced cognitive impairment. following oral administration in squirrel monkeys, heptyl physostigmine (8 mg/kg) induced long- ... | 1992 | 1564524 |
| the effect of head-down tilt and water immersion on intracranial pressure in nonhuman primates. | a headward fluid shift occurs in humans exposed to space-flight. this shift is thought to be the stimulus for the observed reduction in plasma volume, and may produce a sustained rise in intracranial pressure (icp). in order to determine the effect of head-down tilt (hdt) and water immersion on intracranial pressure (icp), five anesthetized rhesus monkeys were fitted with intracranial pressure-monitoring transducers and subjected to -6 degrees hdt followed by head-out thermoneutral (34.7 degrees ... | 1992 | 1567318 |
| studies of an improved rhesus hematopoietic progenitor cell assay. | we have improved rhesus monkey marrow cell growth in semisolid media by means of substituting supplemented calf serum for fetal bovine serum. the cloning efficiency of light-density marrow cells separated on 60% percoll was 126 (+/- 54)/10(5) (n = 12, +/- sd), and for light-density peripheral blood cells 60 (+/- 46)/10(6) (n = 11). thirty-five percent of the colonies were multilineage, whereas the remainder were unilineage colonies composed of erythrocytes, megakaryocytes, and neutrophilic or mo ... | 1992 | 1568458 |
| photoperiod-driven changes in reproductive function in male rhesus monkeys. | environmental lighting, which regulates seasonal breeding in many animal species, has not been examined as a regulator of reproduction or puberty in man or nonhuman primates. in this study we examined the effects of controlled alternating long and short daily photoperiods, independent of other environmental variables, on testicular size and function in rhesus monkeys. sixteen animals, some pubertal, others prepubertal, were individually caged indoors in light-controlled rooms. they were subjecte ... | 1992 | 1569154 |
| recombinant human thyrotropin stimulates thyroid function and radioactive iodine uptake in the rhesus monkey. | the administration of bovine tsh to stimulate thyroid radioactive iodine uptake to detect functioning thyroid tissue in man after surgery for thyroid cancer is rarely, if ever, used, due to allergic reactions and/or the development of tsh antibodies. human (h) tsh would be far less likely to induce allergic reactions or tsh antibodies. recombinant htsh (rec-htsh) was produced by a line of chinese hamster ovary cells that had been transfected with cdna for the two subunit proteins that comprise h ... | 1992 | 1569160 |
| responses of lateral hypothalamic glucose-sensitive and glucose-insensitive neurons to chemical stimuli in behaving rhesus monkeys. | 1. extracellular single neuron activity was recorded in the lateral hypothalamic area (lha) of awake, behaving monkeys, with particular regard to the feeding-related functional characteristics of glucose-sensitive (gs) versus glucose-insensitive (gis) neurons. firing rate changes were recorded by means of carbon fiber, multibarreled glass microelectrodes during 1) microelectrophoretic application of various chemicals, 2) gustatory and olfactory stimulation, and 3) a high fixed-ratio schedule (fr ... | 1992 | 1569466 |
| pathologic features of siv-induced disease and the association of macrophage infection with disease evolution. | since the original isolation of simian immunodeficiency virus (siv) from a macaque with an aids-like disease, numerous studies have demonstrated the close biologic and genetic relationship of the sivs to the hivs. probably most important, the clinical spectrum of disease associated with sivmac/sivsmm infection in rhesus monkeys is strikingly similar to aids in hiv-1-infected human beings. herein are summarized the pathologic features of sivmac-induced disease in a cohort of rhesus monkeys, with ... | 1992 | 1571193 |
| the use of siv-infected rhesus monkeys for the preclinical evaluation of aids drugs and vaccines. | macaque monkeys infected with the simian immunodeficiency virus (siv) can be used for preclinical testing of drugs and vaccines against acquired immunodeficiency syndrome (aids) as well as for the study of aids pathogenesis. a number of pathogenic siv strains that have been well characterized molecularly and biologically are available for animal infection studies. data generated from in vitro drug sensitivity assays have established, for many classes of compounds, a similar degree of antiviral e ... | 1992 | 1571195 |
| genetic and biological comparisons of pathogenic and nonpathogenic molecular clones of simian immunodeficiency virus (sivmac). | simian immunodeficiency virus (siv) is a designation for a group of related but unique lentiviruses identified in several primate species. a viral isolate from a rhesus macaque (i.e., sivmac) causes a fatal aids-like disease in experimentally infected macaques, and several infectious molecular clones of this virus have been characterized. this report presents the complete nucleotide sequence of molecularly cloned sivmac1a11, and comparisons are made with the sequence of molecularly cloned sivmac ... | 1992 | 1571198 |
| siv/hiv recombinants and their use in studying biological properties. | a series of chimeric clones between human immunodeficiency virus type 1 (hiv-1) and simian immunodeficiency viruses (siv) were constructed. viability of the recombinant viruses was dependent on the position of recombination. infectious chimeric viruses between hiv-1 and sivagm (isolated from an african green monkey) and those between hiv-1 and sivmac (isolated from a rhesus monkey) were examined for host cell tropism. viral determinants that restrict the replication of sivagm in human mt-4 cells ... | 1992 | 1571199 |
| concept learning by monkeys with video picture images and a touch screen. | two rhesus monkeys were trained in a same/different task to discriminate digitized computer-stored picture stimuli. the pictures were digitized from 35-mm slides and presented in pairs on a computer monitor. the monkeys were required to touch the pictures and then make a choice response to indicate whether the pictures were identical or nonidentical. the response areas and stimuli were located to the sides of the picture stimuli. responses were defined and monitored by an infrared matrix touch s ... | 1992 | 1573373 |
| a comparative study of mandibular growth patterns in seven animal models. | the use of nonhuman primate experimental models has helped make significant contributions toward the clinical and surgical management of patients with craniofacial disorders. with concerns such as increasing cost, however, alternative models will have to be identified. the present comparative study describes baseline, age-related changes in mandibular growth patterns for seven commonly used animal models. the data was obtained from 144 serial and cross-sectional lateral head radiographs of unope ... | 1992 | 1573484 |
| estimation of regional cerebral utilization of [11c]-l-3,4-dihydroxy-phenylalanine (dopa) in the primate by positron emission tomography. | the intracerebral kinetics of [11c]-labelled l-3,4-dihydroxyphenylalanine, l-dopa, was investigated in rhesus monkeys by positron emission tomography (pet). through the labelling of the l-dopa molecule in different positions and observation of a series of pharmacological challenges it was possible to establish that the kinetic conversion of the radiotracer in the striatum represents the process of decarboxylation to [11c]-labelled dopamine. the rate constant for this process can be estimated usi ... | 1992 | 1574997 |
| brain kinetics of 11 c-labelled l-tryptophan and 5-hydroxy-l-tryptophan in the rhesus monkey. a study using positron emission tomography. | 5-hydroxy-l-tryptophan labelled with 11 c is introduced as a tracer for the in vivo assessment of brain serotonin synthesis in the rhesus monkey using positron emission tomography, pet. increasing radioactivities were seen in the striatal area in contrast to that seen in other brain regions. following 11 c-labelled l-tryptophan an even spread of brain radioactivity was seen. this selective increase most probably results from the decarboxylation of tracer and retention of formed products since no ... | 1992 | 1575951 |
| effect of indomethacin on serum lipids, lipoproteins, prostaglandins and the extent and severity of atherosclerosis in rhesus monkeys. | the present study evaluated indomethacin therapy--a nonsteroidal anti-inflammatory drug--on experimental hyperlipidemia and atherosclerosis in rhesus monkeys. twenty-four monkeys were divided randomly into four groups of six. two groups received stock pellet diet and two were given an atherogenic diet for six months. after this period, one stock diet-fed group and one atherogenic diet-fed group were treated with oral indomethacin (2.5 mg) on alternate days for a further six months. serum lipids ... | 1992 | 1576566 |
| the response of neurons in areas v1 and mt of the alert rhesus monkey to moving random dot patterns. | we studied the response of single units to moving random dot patterns in areas v1 and mt of the alert macaque monkey. most cells could be driven by such patterns; however, many cells in v1 did not give a consistent response but fired at a particular point during stimulus presentation. thus different dot patterns can produce a markedly different response at any particular time, though the time averaged response is similar. a comparison of the directionality of cells in both v1 and mt using random ... | 1992 | 1577111 |
| cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey. | quantitative studies were conducted to determine the number and size of cholinergic neurons in the medial septal nucleus of four aged (23-25 years old) and four young (10-12 years old) rhesus monkeys. all of the animals had been tested on an extensive battery of learning and memory tasks prior to these experiments. two of the aged monkeys displayed a pattern of recognition memory deficits that resembled the effects of medial temporal lobe damage. the postmortem anatomical data were analyzed in r ... | 1992 | 1578278 |
| vasopressin antagonist inhibition of clotting factor release in the rhesus monkey (macaca mulatta). | the antidiuretic (v2) agonist, ddavp, stimulates release of the clotting factors von willebrand factor (vwf) and factor viiic (fviiic) in humans. the objective of these studies was to identify and characterize ddavp stimulation of clotting factor release in pentobarbital-anesthetized rhesus monkeys using v2 receptor agonists (ddavp, sk&f 101926, sk&f 104146, sk&f 104244) and a v2 receptor antagonist (sk&f 105494) given i.v. ddavp (3.0 micrograms/kg) stimulated release of vwf, fviiic and renin an ... | 1992 | 1578361 |
| percutaneous absorption of [14c]chlordane from soil. | the objective was to determine percutaneous absorption of chlordane in vitro and in vivo from soil into and through skin. the data are needed to calculate the absorbed dose of chlordane from soil, which is then used to assess the toxicity risk. chlordane, an insecticide for which residues exist in soil, is restricted currently to use for termite control. chlordane is highly lipophilic with little or no movement out of soil. soil (yolo county 65-california-57-8; 26% sand, 26% clay, 48% silt, 0.9% ... | 1992 | 1578510 |
| neuroscience findings in aids: a review of research sponsored by the national institute of mental health. | 1. the human immunodeficiency virus (hiv-1) infects cells in both the immune system and the brain, but these effects are not independent. 2. research funded by the national institute of mental health (nimh) has been directed at identifying some of the mechanisms by which hiv-1 infects the brain, produces pathology, causes behavioral changes, and alters immune responses. 3. hiv-1-associated peptides have been shown to produce immunological changes without active virus present and there is also ev ... | 1992 | 1579634 |
| mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. | the authors investigated the importance of natural antibody and complement in the pathogenesis of hyperacute xenograft rejection using in vivo and in vitro pig to primate models. studies were carried out in rhesus monkeys transplanted with a pig heart or kidney in which hyperacute rejection was observed within a few hours. the rejected organs showed deposits of igm, c3, c4, c5, and c9 neoantigen along small blood vessels, but few deposits of factors b and p. removal of anti-endothelial cell "nat ... | 1992 | 1580328 |
| ozone-induced acute tracheobronchial epithelial injury: relationship to granulocyte emigration in the lung. | to investigate the relationship between granulocyte emigration and epithelial injury in specific airway generations of the tracheobronchial tree following short-term ozone exposure, we exposed rhesus monkeys for 8 h to 0.00 (controls) or 0.96 ppm ozone with post-exposure periods of 1, 12, 24, 72, and 168 h in filtered air before necropsy. there were five control and three exposed monkeys for each of the post-exposure times for a total of 20 monkeys. neutrophils isolated from peripheral blood and ... | 1992 | 1581072 |
| ige-mediated rhesus monkey asthma: natural history and individual animal variation. | this report reviews the 20 years of experience with naturally occurring allergy in dogs and allergic rhesus monkeys. the primate model of allergy is characterized by ige-mediated cutaneous and respiratory responses to ascaris antigen. individual assessments of these monkeys have been carried out over several years and separate populations which are analogous to human ige-mediated allergic populations defined. these populations are as follows: (1) monkeys which have persistent and consistent ige- ... | 1992 | 1582707 |
| efferent cortical connections of multimodal cortex of the superior temporal sulcus in the rhesus monkey. | the cortex of the upper bank of the superior temporal sulcus (sts) in the rhesus monkey contains a region that receives overlapping input from post-rolandic sensory association areas and is considered multimodal in nature. we have used the fluorescence retrograde tracing technique in order to answer the question of whether multimodal areas of the sts project back to post-rolandic sensory association areas. additionally, we have attempted to answer the question of whether the projections from the ... | 1992 | 1583161 |
| alterations in the course of experimental syphilis associated with concurrent simian immunodeficiency virus infection. | case reports suggest that the course of syphilis is altered in patients infected with human immunodeficiency virus (hiv). to investigate this issue, a model of syphilis in rhesus macaques with and without simian immunodeficiency virus (siv) was developed. after intradermal inoculation with treponema pallidum, 2 siv-infected monkeys had persistent ulcerative primary lesions and 1 developed secondary syphilis. two siv-uninfected controls developed transient nonulcerative primary lesions. only the ... | 1992 | 1583318 |
| diazepam binding inhibitor processing in the rhesus monkey brain: an immunocytochemical study. | immunocytochemical methods were used to study the regional and cellular distribution of diazepam binding inhibitor (dbi)-, odn (dbi 33-50)- and ttn (dbi 17-50)-like immunoreactivity (li) in monkey brain. dbi-, odn- and ttn-li were found to have similar regional but different cellular distributions. the most intense staining was detected in limbic structures, especially the amygdala. the most notable staining discrepancy was the weak-to-moderate uniform dbi-li and the very high patchy odn-li and ... | 1992 | 1586472 |
| safety, immunogenicity, and efficacy in monkeys and humans of invasive escherichia coli k-12 hybrid vaccine candidates expressing shigella flexneri 2a somatic antigen. | a live, oral shigella vaccine, constructed by transfer of the 140-mda invasiveness plasmid from shigella flexneri 5 and the chromosomal genes encoding the group- and type-specific o antigen of s. flexneri 2a to escherichia coli k-12, was tested in humans. designated ecsf2a-1, this vaccine produced adverse reactions (fever, diarrhea, or dysentery) in 4 (31%) of 13 subjects who ingested a single dose of 1.0 x 10(9) cfu, while at better-tolerated doses (5.0 x 10(6) to 5.0 x 10(7) cfu), it provided ... | 1992 | 1587589 |
| in vivo percutaneous absorption and skin decontamination of alachlor in rhesus monkey. | the objectives of this study were to determine the percutaneous absorption of alachlor relative to formulation dilution with water, and to determine the ability of soap and water, and of water only, to remove alachlor from skin, relative to time. alachlor is a preemergence herbicide. the in vivo percutaneous absorption of alachlor in rhesus monkeys was 17.3 +/- 3.3, 15.3 +/- 3.9, and 21.4 +/- 14.2% for 24-h skin exposure to lasso formulation diluted 1:20, 1:40, and 1:80, respectively. in vivo, t ... | 1992 | 1588637 |
| serum total bile acid concentration in rhesus monkeys: effects of feeding cholesterol and inhibiting cholesterol absorption and synthesis. | the serum total bile acid concentration was measured in rhesus monkeys fed diets practically free of cholesterol and with added cholesterol at two levels. also, the effects of inhibiting cholesterol absorption by feeding plant sterols and inhibiting cholesterol synthesis by feeding triparanol upon the serum total bile acid levels were studied. cholesterol feeding significantly increased the serum bile acid concentration. the serum bile acid level was decreased in the high responders fed plant st ... | 1992 | 1590673 |
| [dopa-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated hemiparkinsonian monkeys]. | infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) into the right common carotid artery of 5 rhesus monkeys produced hemiparkinsonian syndrome in the contralateral limbs which responded to madopa or apomorphine therapy. moreover, these two drugs induced circling away from the mptp-treated side, amphetamine induced rotation toward the mptp-treated side. long-term use of madopa developed a peak-dose dyskinesia of the face and the limbs contralateral to the mptp-treated side. the ipsil ... | 1992 | 1591961 |
| ageing compromises gastrointestinal mucosal immune response in the rhesus monkey. | most research on the effects of ageing on gut mucosal immunity has been performed using rodents. however, there are inherent difficulties in the extrapolation of rodent data to humans. this study was initiated to define age-related changes in the gastrointestinal (gi) mucosal immune response in non-human primates. antibody responses were measured in young and old rhesus monkeys (macaca mulatta) immunized intraduodenally with cholera toxin (ctx)/cholera toxoid (ctd). antigen-specific immunoglobul ... | 1992 | 1592437 |
| progesterone inhibits the estrogen-induced gonadotropin surge in the rhesus monkey independent of endogenous opiates. | administration of an estrogen challenge during the luteal phase, a time when progesterone concentrations are elevated, fails to elicit a gonadotropin-positive feedback response. the purpose of the present study was to determine if endogenous opiates are involved in the mechanism by which progesterone blocks the estrogen-induced gonadotropin surge in monkeys. to this end, rhesus monkeys in the luteal phase were pretreated with either saline or various regimens of nalmefene, a long-acting opiate a ... | 1992 | 1592876 |
| effects of arecoline and scopolamine on open field behavior of adult monkeys treated with lead during the first year postpartum. | nursery-reared rhesus monkeys were treated with no or moderate levels of lead during the first year postpartum. previously, the lead-treated monkeys exhibited behaviors in the nonhuman primate version of the open field (10) resembling those caused by hippocampal lesions. the current study investigated the mechanism(s) underlying these lead-related effects using a cholinergic agonist (arecoline) and antagonist (scopolamine) as pharmacological probes that were administered prior to open field test ... | 1992 | 1593983 |
| evaluation of the discriminative stimulus and reinforcing effects of sertraline in rhesus monkeys. | rhesus monkeys (n = 4) were allowed to self-administer cocaine (0.03 mg/kg/injection) under a fixed-ratio 10 (fr 10) schedule during daily 2-h experimental sessions. when responding was stable, a variety of doses of sertraline, a serotonin reuptake blocker under development as an antidepressant, were made available for self-administration. baseline conditions were reinstated between doses of sertraline. cocaine 0.03 mg/kg/injection maintained high rates of injection, while total saline injection ... | 1992 | 1594647 |
| in the rhesus monkey placental retention after fetectomy at 121 to 130 days' gestation outlasts the normal duration of pregnancy. | our aim was to reassess the role of the fetus in the initiation of parturition in nonhuman primates. we tested the effect of the removal of the fetus at 121 to 130 days' gestation on the duration of gestation in pregnant rhesus monkeys. | 1992 | 1595808 |
| age-related loss of ciliary muscle mobility in the rhesus monkey. role of the choroid. | ciliary muscle topography was studied in rhesus monkey eyes (aged 6 to 29 years) bisected meridionally through cornea and optic nerve head. half of each eye was incubated in atropine sulfate, the other in pilocarpine hydrochloride, and both were then processed for histologic study. several ciliary muscle sections from the original cut margin and the middle of the half eyes were traced and compared quantitatively. in sections from the middle, where the attachments of the muscle were presumably in ... | 1992 | 1596237 |
| bone mass and bone cellular variations after five months of physical training in rhesus monkeys: histomorphometric study. | five rhesus monkeys (macaca mulatta), a suitable nonhuman model, performed 5 months of rope-climbing exercise. duration of the training sessions was progressively increased to reach 1 hour/day after 1 month of training and was maintained until the end of the experiment. bone mass parameters, bone resorption, and bone formation activity were measured by histomorphometric analysis on iliac crest bone biopsies before and after the experiment. mineral apposition rate was measured in cortices and tra ... | 1992 | 1596777 |
| detection of simian immunodeficiency virus rna from infected rhesus macaques by the polymerase chain reaction. | a rapid method for the detection of simian immunodeficiency virus (siv) rna from peripheral blood mononuclear cells (pbmc) of experimentally infected rhesus macaques by the polymerase chain reaction (pcr) is reported. the pcr was carried out with a complementary dna (cdna) template using 3 pairs of primers that were designed to anneal to homologous sequences in conserved regions of 3 molecular clones of sivmac. the specificity of the primers was confirmed by performing the pcr with template dna ... | 1992 | 1597502 |
| articulatory and social factors influence the acoustic structure of rhesus monkey vocalizations: a learned mode of production? | this report presents results that show that the acoustic structure of the "coo" vocalization of rhesus macaques (macaca mulatta) varies between members of different matrilines. in the case examined, members of one matriline produce coos that are acoustically distinctive from all other matrilines and the difference is primarily due to spectral dampening and the presence of energy bands between the primary harmonics of the call. perceptually, these acoustic modifications lead to what human listene ... | 1992 | 1597608 |
| spontaneous nystagmus and gaze-holding ability in monkeys after intravitreal picrotoxin injections. | 1. eye movements were measured in three rhesus monkeys after monocular intravitreal injections of picrotoxin, a gamma-aminobutyric acid (gaba) antagonist. the effects of this drug were tested when the animals were in a completely dark room, when they performed a smooth pursuit task, and when they viewed either a stationary pattern or a full-field optokinetic pattern rotating horizontally. 2. between 15 and 20 min after the injection, a sustained conjugate spontaneous nystagmus developed in the d ... | 1992 | 1597702 |
| susceptibility of macaca fascicularis monkeys from mauritius to different species of plasmodium. | macaca fascicularis monkeys from mauritius were shown to be susceptible via sporozoite inoculation to 7 species of plasmodium (p. fragile, p. coatneyi, p. gonderi, p. inui, p. cynomolgi, p. knowlesi, and p. fieldi), indigenous to macaques in southeastern asia. four monkeys were sequentially infected with different species of plasmodium to determine maximum and course of parasitemia. in 2 nonsplenectomized monkeys, p. fragile developed maximum parasite counts of only 134 and 155/microliters. for ... | 1992 | 1597796 |
| renin inhibitors containing c-termini derived from mercaptoheterocycles. | a series of transition-state analogues having heterocyclythio c-termini has been synthesized and evaluated for inhibition of human renin. addition of mercaptoheterocycles to a chiral boc-amino epoxide intermediate led, after several steps, to the target [(2r,3s)-3-(bocphehis-amino)-4-cyclohexyl-2-hydroxy-1-butyl]thio derivatives. oxidation of the thioether to sulfone was also investigated. several of the compounds, especially those derived from n1-substituted-5-mercaptotetrazoles or n4-substitut ... | 1992 | 1597860 |
| vestibular input to visual-tracking neurons in area mst of awake rhesus monkeys. | | 1992 | 1599231 |
| dead zone for express saccades. | the saccadic eye movements of three humans and one non-human primate (a male rhesus monkey) have been measured for target eccentricities between 0.3 and 15 deg. with a gap task (fixation point offset precedes target onset by 200 ms) and a target at 4 deg, all subjects produced reasonable amounts of express saccades as indicated by a clear peak in the distribution of their saccadic reaction times (srt): about 100 ms in human subjects and 70 ms in the monkey. this peak disappeared with decreasing ... | 1992 | 1601099 |
| effect of nocturnal atrial demand cardiac pacing on diurnal hemodynamic patterns. | heart rate (hr), stroke volume (sv), intra-arterial blood pressure, and central venous pressure were recorded on a beat-to-beat basis, 18 h/day (1800-1200 h the following day), for approximately 2 mo in four monkeys (macaca mulatta). cardiac output, left ventricular work, and total peripheral resistance were derived from these primary measurements. during the 1st mo we measured these parameters under control conditions, and during the 2nd mo the animals were studied while hr was paced by atrial ... | 1992 | 1601788 |
| systematic nocturnal atrial demand pacing results in high-output heart failure. | beat-to-beat parameters of heart rate (hr), intra-arterial blood pressure (bp), central venous pressure, and derived indexes of cardiac output and total peripheral resistance were recorded 18 h/day (from 1800 to 1200 h the following day) in four monkeys (macaca mulatta) during 20 control days followed by 20 days of atrial demand pacing. the pacing rate was set at approximately 10 beats/min above the fastest hourly average hr recorded during the control period, i.e., sufficient to prevent the nor ... | 1992 | 1601789 |
| a new threat to public health: organochlorines and food. | ambient levels of persistent toxic chemicals, chemicals that persist for decades in the environment, have reached levels high enough to affect the health of children. the organochlorines (pcbs, ddt and the dioxin family) accumulate in human adipose tissue. pregnant women pass the contamination to their fetuses. the developing nervous system is the most vulnerable. neurobehavioral deficits, including short-term memory loss, are detected in children born to mothers at the high end of the distribut ... | 1992 | 1603449 |
| development and characterization of monoclonal antibodies to lymphocyte cell surface antigens of the rhesus monkey. | three monoclonal antibodies directed against rhesus lymphocyte cell surface antigens are described. a pan-t mab, t64, and a t suppressor mab, t35, showed phenotypic and functional specificity for both human and rhesus cells. in contrast, a third mab, n42, identifying natural killer cells in rhesus peripheral blood leukocytes, was not crossreactive with the corresponding homologous human cells. n42 reacted with the same cells identified by leu 11a and leu 11b in rhesus pbl and in a functional ass ... | 1992 | 1604487 |
| disconjugate ocular motor adaptation in rhesus monkey. | we report a model for inducing disconjugate, orbital-position dependent, ocular motor adaptation in the rhesus monkey. animals wore a combination of laterally-displacing prisms placed in front of one eye calling for a discrete change in ocular alignment when the eyes reached particular orbital positions. after wearing the prism combination the animals developed adaptive changes both in static alignment during fixation and in dynamic alignment during eye movements. these changes persisted with on ... | 1992 | 1604836 |
| genital secretory immune response to chronic simian immunodeficiency virus (siv) infection: a comparison between intravenously and genitally inoculated rhesus macaques. | the humoral and genital secretory immune response to chronic siv infection was compared between female rhesus macaques inoculated by i.v. or intravaginal routes. total igg levels in serum were 10-fold higher in siv-infected animals when compared with uninfected controls. vaginal washes from normal macaques contained predominantly iga and igg, while those from siv-infected animals contained high levels of igg. the siv-infected animals had high titres of siv-specific igg in serum, with lower but d ... | 1992 | 1606737 |
| microstimulation in visual area mt: effects on direction discrimination performance. | physiological and behavioral evidence suggests that the activity of direction selective neurons in visual cortex underlies the perception of moving visual stimuli. we tested this hypothesis by measuring the effects of cortical microstimulation on perceptual judgements of motion direction. to accomplish this, rhesus monkeys were trained to discriminate the direction of motion in a near-threshold, stochastic motion display. for each experiment, we positioned a microelectrode in the middle of a clu ... | 1992 | 1607944 |
| osseous healing of the sagittal ramus osteotomy: a histologic comparison of rigid and nonrigid fixation in macaca mulatta. | twenty-three adult female rhesus monkeys underwent advancement of the mandible by the sagittal split ramus osteotomy. twelve had the proximal and distal segments wired together and underwent 6 weeks of maxillomandibular fixation (mmf). eleven animals had bicortical bone screws placed between the segments and no postsurgical mmf. the animals were killed at 6 and 12 weeks and the osteotomy sites were prepared for histologic examination. overall, the results showed that the two groups of animals un ... | 1992 | 1608001 |
| coherent 25- to 35-hz oscillations in the sensorimotor cortex of awake behaving monkeys. | synchronous 25- to 35-hz oscillations were observed in local field potentials and unit activity in sensorimotor cortex of awake rhesus monkeys. the oscillatory episodes occurred often when the monkeys retrieved raisins from a klüver board or from unseen locations using somatosensory feedback; they occurred less often during performance of repetitive wrist flexion and extension movements. the amplitude, duration, and frequency of oscillations were not directly related to movement parameters in be ... | 1992 | 1608977 |
| 'gastrospirillum hominis', another gastric spiral bacterium. | 'gastrospirillum hominis' is a 'new' tightly coiled gram-negative bacterium carrying bundles of sheathed polar flagella. it has been rather infrequently detected in antral and, even more rarely, in fundic mucosa samples removed at endoscopy from patients investigated for helicobacter pylori colonization. until now, it has remained noncultivable but has successfully been maintained in laboratory mice. its identity with similar bacteria found in the stomachs of cats, dogs, monkeys, pigs, and other ... | 1992 | 1611710 |
| comparison of hemagglutination and hemadsorption tests for influenza detection. | hemagglutination (ha) testing of the supernatant of primary rhesus monkey kidney cell culture tubes inoculated with clinical specimens was compared with hemadsorption (had) of the same tube for identifying the presence of hemagglutinin activity due to influenza. a total of 476 respiratory specimens were screened for influenza by this method. the 127 influenza or parainfluenza positive cultures showed 100% concordance between the two tests. all negative cultures were both also negative by ha and ... | 1992 | 1611853 |
| vasopressin mediates the interleukin-1 alpha-induced decrease in luteinizing hormone secretion in the ovariectomized rhesus monkey. | arginine vasopressin (avp) has previously been shown to participate in the neuroendocrine control of the adrenal axis. in this study we investigated the role of avp in the mechanisms linking stress and decreased gonadotropin secretion and evaluated the action of an avp antagonist on interleukin-1 alpha (il-1 alpha)-induced changes in gonadotropin and cortisol release in the primate. adult ovariectomized rhesus monkeys were given a 30-min intracerebroventricular infusion of il-1 alpha (2.1 microg ... | 1992 | 1611995 |
| regulation of chorionic gonadotropin-alpha and chorionic somatomammotropin messenger ribonucleic acid expression by 8-bromo-adenosine 3',5'-monophosphate and dexamethasone in cultured rhesus monkey syncytiotrophoblasts. | we wished to establish an in vitro culture system to examine gene expression in the context of differentiated function with rhesus monkey syncytiotrophoblasts. chorionic villous tissue from placentas obtained at cesarean section was dispersed with trypsin and dnase and fractionated on a 5-70% percoll gradient. when placed in culture, cells from a mononuclear fraction demonstrated to be very highly enriched (95-97% pure) for cytotrophoblasts aggregated and began to form syncytia within 24 h in cu ... | 1992 | 1612035 |
| in vivo imaging of insulin receptors in monkeys using 18f-labeled insulin and positron emission tomography. | we previously described a prosthetic group methodology for incorporating 18f into peptides and showed that 18f-labeled insulin (18f-insulin) binds to insulin receptors on human cells (im-9 lymphoblastoid cells) with affinity equal to that of native insulin (1). we now report studies using 18f-insulin with positron emission tomography to study binding to insulin receptors in vivo. positron emission tomography scans were performed in six rhesus monkeys injected with 0.3-1.4 mci of 18f-insulin (app ... | 1992 | 1612200 |
| estradiol concentrations, fat deposits, and reproductive strategies in male rhesus macaques. | squirrel monkeys (saimiri spp.) are thought to undergo a unique pattern of seasonal weight change among the primates that reflects a fatted male phenomenon. but many male mammals, including rhesus macaques (macaca mulatta), undergo circannual weight changes concurrent with mating season activity. four adult male rhesus macaques living in a heterosexual social group in an outdoor enclosure were studied over a 2-year period in order to ascertain potential mechanisms underlying seasonal weight chan ... | 1992 | 1612569 |
| maternal influences on body temperature in the infant primate. | the following study investigated the diurnal variation in body temperature of the young monkey infant and assessed the role that the mother plays in the development of the temperature rhythm. using an implantable biotelemetry system, core body temperature and motoric activity were evaluated in maternally-reared and hand-reared rhesus monkey infants across the first several months of life. our results indicated that the nocturnal temperatures of hand-reared infants are lower than those of mother- ... | 1992 | 1615060 |
| a pc program for growth prediction in the context of rao's polynomial growth curve model. | we consider the problem of growth prediction in the context of rao's [1] one-sample polynomial growth curve model and provide a pc program, written in gauss, to perform the associated computations. specifically, the problem considered is that of estimating the value of the measurement under consideration for a "new" individual at the tth time point given measurements on that individual at t-1 previous points in time and the values of the measurement on n "similar" individuals at all t time point ... | 1992 | 1617952 |
| alpha-isoenzyme of alcohol dehydrogenase from monkey liver. cloning, expression, mechanism, coenzyme, and substrate specificity. | the cdna for the alpha-isoenzyme from rhesus monkey (macaca mulatta) liver was cloned and expressed in yeast. the alpha-isoenzymes of human and monkey liver alcohol dehydrogenase differ from the other human and horse liver enzymes in having met57, ala93, and val116 instead of leu57, phe93, and leu116 in the substrate binding pocket and gly47 instead of arg47 near the pyrophosphate moiety of the coenzyme. the effects of these differences on the kinetic mechanism, substrate specificity, and coenzy ... | 1992 | 1618764 |
| persistence of impaired insulin secretion in infant rhesus monkeys that had been hyperinsulinemic in utero. | chronic in utero hyperinsulinemia in the fetal rhesus monkey produces a number of changes in the fetus that are similar to those found in the human infant of the diabetic mother, including macrosomia, selective organomegaly, and altered insulin secretion during the neonatal period. the chronically hyperinsulinemic fetal rhesus model has been used to test the hypothesis that the effects of chronic hyperinsulinemia persist beyond the neonatal period into later life and may, in part, be responsible ... | 1992 | 1619018 |
| steroid hormone receptors in the adrenal glands of fetal and adult rhesus monkeys. | sex steroid hormone receptors have been identified in the adrenal glands of rodents and may have a role in adrenal function. the highly estrogenic environment during pregnancy has been proposed to influence steroidogenesis by the fetal zone of the primate fetal adrenal gland. in order to determine whether these effects involve receptor-mediated mechanisms, we have examined the concentration and distribution of estrogen receptor (er), androgen receptor, and progesterone receptor (pr) in the adren ... | 1992 | 1619023 |
| inactivated lassa virus elicits a non protective immune response in rhesus monkeys. | we attempted to protect three rhesus monkeys from lassa fever by vaccination with a preparation of purified whole lassa virus which had been inactivated by gamma irradiation. the vaccinated monkeys developed antibodies against the three major viral proteins of lassa virus demonstrated by radioimmunoprecipitation. when the three vaccinated monkeys and two unvaccinated control monkeys were challenged all five became severely ill and died. prior to death a secondary, high-titer antibody response to ... | 1992 | 1619397 |
| in utero stem cell therapy. | in utero stem cell transplantation offers the potential for treating a number of genetic disorders. the combination of fetal immunotolerance and fetal marrow space makes the fetus an excellent transplant recipient. experiments on the mouse, sheep and rhesus monkey have indicated that in utero transplantation is feasible. human trials are currently beginning. | 1992 | 1619604 |
| calcium and zinc retention from protein hydrolysate formulas in suckling rhesus monkeys. | to determine calcium and zinc retention from infant formulas based on protein hydrolysates. | 1992 | 1621661 |
| pharmacokinetics of l-671,329 in rhesus monkeys and dba/2 mice. | the time course of plasma drug levels and urinary recovery for two lipopeptide antifungal antibiotics, l-671,329 and cilofungin, were measured in male rhesus monkeys (macaca mulatta) and in female dba/2 mice. the antibiotics were administered intravenously at 10 mg/kg of body weight in phosphate-buffered saline-26% polyethylene glycol for the rhesus monkeys and in 5% dimethyl sulfoxide for the mice. plasma and urine drug concentrations were determined by high-pressure liquid chromatography and/o ... | 1992 | 1622170 |
| simian immunodeficiency virus-specific cytotoxic t lymphocytes are present in the aids-associated skin rash in rhesus monkeys. | an infiltration of cd8+ lymphocytes in the dermis and epidermis underlies the skin rash that commonly occurs as a primary manifestation of an aids virus infection. these cutaneous lymphocytes were characterized in simian immunodeficiency virus of macaques (sivmac)-infected rhesus monkeys. skin rash-associated lymphocytes exhibited greater lysis of sivmac-expressing target cells and a higher cloning efficiency for sivmac-specific effector t cells than pbl. moreover, both sivmac envelope- and gag- ... | 1992 | 1624810 |