| inhibitory effects of calycosin isolated from the root of astragalus membranaceus on melanin biosynthesis. | tyrosinase is a key enzyme for melanin biosynthesis, and hyperpigmentation disorders are associated with abnormal accumulation of melanin pigments, which can be reduced by treatment with depigmenting agents. a methanol extract of astragalus membranaceus showed inhibitory activity against mushroom tyrosinase. the active compound was purified from the methanol extract of a. membranaceus and, following several chromatographic methods, was identified as calycosin via spectroscopic analysis. the resu ... | 2009 | 19182387 |
| astragaloside iv attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats. | astragalus membranaceus is widely used to treat stroke and chronic debilitating diseases in china, but the mechanism has not been fully demonstrated to data. in the present study, we, using astragaloside iv, a purified extract from astragalus membranaceus, to a focal cerebral ischemia/reperfusion rat model, aimed to investigate the effect of astragaloside iv on the permeability of the blood-brain barrier since disruption of blood-brain barrier induced by ischemia/reperfusion leads to serious bra ... | 2009 | 19374856 |
| a novel anticancer effect of astragalus saponins: transcriptional activation of nsaid-activated gene. | astragalus membranaceus has been used to ameliorate the side effects of antineoplastic drugs because of its immunomodulating nature. we had recently demonstrated that total astragalus saponins (ast) possess anticarcinogenic and proapoptotic properties in human colon cancer cells and tumor xenograft. in this study, we identified nsaid-activated gene (nag-1) as a potential molecular target of ast. the growth-inhibitory and proapoptotic effects of ast were assessed in a panel of human cancer cell l ... | 2009 | 19384947 |
| preventive effects of a fractioned polysaccharide from a traditional chinese herbal medical formula (yu ping feng san) on carbon tetrachloride-induced hepatic fibrosis. | the study was to investigate the prevention effects and possible mechanism of yu ping feng san fractioned polysaccharide (ypf-p) on ccl(4)-induced liver fibrosis in rats. | 2010 | 20636883 |
| [astragalus membranaceus improves endothelial-dependent vasodilator function in obese rats]. | to investigate the effect of astragalus membranaceus (am) on endothelial-dependent (edv) and non- dependent (eiv) vascular relaxation in ex vivo thoracic aortic rings of obese rats. | 2010 | 20117973 |
| [transformation of astragaloside iv in bidirectional solid fermenting of astragalus membranaceus]. | to study the transformation of astragaloside iv in bidirectional solid fermenting of astragalus membranaceus var. mongholicus. | 2010 | 20681294 |
| [effects of heavy metal on astragalus membranaceus seeds germination and physiological target]. | to study the effects of heavy metals on germination and antioxidant systems of the seeds of astragalus membranaceus. | 2010 | 20707058 |
| neuroprotective effects of astragaloside iv in 6-hydroxydopamine-treated primary nigral cell culture. | parkinson's disease (pd) is caused by a progressive degeneration of dopaminergic neurons in the substantia nigra. oxidative stress and neural degeneration are suggested to be involved in the pathogenesis of parkinson's disease. in the present study, astragaloside iv (as-iv) extracted from the dried root of astragalus membranaceus, a well-known chinese medicine used for the treatment of neurodegenerative diseases, was investigated for its capacity to protect dopaminergic neurons in experimental p ... | 2009 | 19409437 |
| biphasic positive effect of formononetin on metabolic activity of human normal and osteoarthritic subchondral osteoblasts. | osteoarthritis is a multifactorial disease characterized by loss of articular cartilage and subchondral plate thickening. therefore, biochemical analysis of the underlying bone tissue has provided important information for treatment of osteoarthritis. in this study, we determined the potential role of formononetin, a phytoestrogen isolated from astragalus membranaceus to alter the expression of metabolic markers and cytokine production of human normal osteoblasts (obs) and osteoarthritis subchon ... | 2010 | 20138155 |
| suppressive effects of swainsonine on c6 glioma cell in vitro and in vivo. | swainsonine, an extract from astragalus membranaceus, is known for its anti-cancer effects and could prevent metastases. in order to investigate the effects and mechanisms of swainsonine in c6 glioma cells, we carry out correlated experiments in vitro and in vivo. after treatment with swainsonine, the effective dose and ic(50) value of swainsonine in the c6 glioma cell were examined using the mtt assay. cell cycle distribution and apoptotic rates were analyzed using fcm and [ca(2+)](i) was measu ... | 2009 | 19427771 |
| astragalus membranaceus injection delayed allograft survival related with cd4+ cd25+ regulatory t cells. | recently it has been reported that astragalus membranaceus injection (ami) inhibits immune responses, but whether it affects alloimmunity is not clear. it has been shown that the cd4(+) cd25(+) regulatory t cells (treg) down-regulate immune responses. the aim of our study was to investigate the effects of ami on allograft survival and its relation to treg. | 2010 | 21094858 |
| inhibitory effects of two major isoflavonoids in radix astragali on high glucose-induced mesangial cells proliferation and ages-induced endothelial cells apoptosis. | radix astragali, the dried roots of astragalus membranaceus var. mongholicus, is well known to have a protective effect on diabetic nephropathy. however, the effects of isoflavonoids in radix astragali on glomerular cells, which play a key role in the development of diabetic vascular complications, remain largely unknown. thus, the purpose of this study was to investigate in vitro the effect of calycosin and calycosin-7-o- β-d-glucoside, two major isoflavonoids in radix astragali, on high glucos ... | 2010 | 21157685 |
| [the effect of astragalus membranaceus (fisch) bge. on lipid peroxidation and no level of myocardium from rats with diabetic nephropathy]. | to study the effect of astragalus membranaceus (fisch) bge. on the lipid peroxidation and no level of myocardium from rats with diabetic nephropathly. | 2001 | 21171416 |
| protective effects of astragaloside iv on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells. | astragaloside iv is the primary pure saponin isolated from astragalus membranaceus, one of the valuable traditional medical herbs. antifibrotic activities of astragalus membranaceus have been extensively proved. | 2009 | 19429320 |
| identification of major constituents in the traditional chinese medicine "qi-shen-yi-qi" dropping pill by high-performance liquid chromatography coupled with diode array detection-electrospray ionization tandem mass spectrometry. | an hplc-dad-esi-ms(n) method was developed for simultaneous analysis of major chemical constituents in "qi-shen-yi-qi" dropping pill, a traditional chinese medicine (tcm) widely used for treating cardiovascular diseases. the chromatographic separation was performed on an intertsil ods-3 c(18) column (4.6 mm x 250 mm, 5 microm), whilst water with 0.05% acetic acid and acetonitrile were used as mobile phase. on the basis of the characteristic uv absorption profile, the information of molecular wei ... | 2008 | 18387767 |
| xiang-qi-tang increases avian pathogenic escherichia coli-induced survival rate and regulates serum levels of tumor necrosis factor alpha, interleukin-1 and soluble endothelial protein c receptor in chicken. | xiang-qi-tang (xqt) is a chinese herbal formula containing rhizoma cyperi, andrographis paniculata and astragalus membranaceus. the present study investigated the effects of xqt on the mortality and inflammatory mediators in a chicken model challenged with avian pathogenic escherichia coli (apec). to detect the effect of xqt, the chickens were pretreated with the formula 12 h before being challenged with 10(8) colony forming unit (cfu) of apec. the results showed that 0.6 g/kg xqt significantly ... | 2011 | 21372388 |
| the telomerase activator ta-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. | here, we show that a small-molecule activator of telomerase (ta-65) purified from the root of astragalus membranaceus is capable of increasing average telomere length and decreasing the percentage of critically short telomeres and of dna damage in haploinsufficient mouse embryonic fibroblasts (mefs) that harbor critically short telomeres and a single copy of the telomerase rna terc gene (g3 terc(+/-) mefs). importantly, ta-65 does not cause telomere elongation or rescue dna damage in similarly t ... | 2011 | 21426483 |
| wound-healing activity of astragali radix in rats. | inhibition of inflammatory responses, acceleration of basal cell growth and balanced synthesis of the extracellular matrix (ecm) are important in the healing of open cutaneous wounds. to evaluate the wound-healing effects of astragali radix (ar) (the root of astragalus membranaceus [fisch.]), experimental open wounds were made on the dorsal side of rats under anesthesia. boiling water extracts of ar, soaked into a hydrophilic foam dressing, were topically applied to the wounds once a day for 11 ... | 2009 | 19455264 |
| astragaloside iv inhibits adenovirus replication and apoptosis in a549 cells in vitro. | astragaloside iv, purified from the chinese medical herb astragalus membranaceus (fisch) bge and astragalus caspicus bieb, is an important natural product with multiple pharmacological actions. this study investigated the anti-advs effect of astragaloside iv on hadv-3 (human adenovirus type 3) in a549 cell. | 2011 | 21492171 |
| astragaloside iv attenuates impulse noise-induced trauma in guinea pig. | abstract conclusion. these results suggest that the beneficial effect of astragaloside iv on impulse noise-induced hearing loss may be due to its ability to inhibit inducible nitric oxide synthase (inos) and prevent the formation of reactive nitrogen species (rns). objective: astragaloside iv is the major active constituent of astragalus membranaceus, which has been widely used for the treatment of diseases in china due to its antioxidant properties. inos and rns are involved in damage induced b ... | 2011 | 21526907 |
| astragaloside iv improves metabolic syndrome and endothelium dysfunction in fructose-fed rats. | the prevalence of metabolic syndrome has increased in modern society and the condition is proving to be a common precursor of cardiovascular disease. the aim of the present study was to investigate whether astragaloside iv, a major active constituent of astragalus membranaceus (fisch) bge., is able to prevent the development of hypertension and endothelial dysfunction in fructose-fed rats. rats were fed with 10% fructose in their drinking water for 8 weeks. from the beginning of week 5, two grou ... | 2011 | 21555978 |
| astragaloside iv stimulates angiogenesis and increases hif-1{alpha} accumulation via pi3k/akt pathway. | astragaloside iv is the major active constituent of astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases in china. this study aims to determine the angiogenic effect of astragaloside iv and its underlying mechanism. we employed 3-(4,5-dimeth-ylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (mtt) assay, western blotting, real-time pcr and immunofluorescence to detect the effect of astragaloside iv on proliferation of human umbilical vein endothelial cel ... | 2011 | 21576377 |
| [regulation of vitreoscilla hemoglobin on biosynthesis of astragaloside iv]. | in the present study, the regulation of vitreoscilla hemoglobin (vhb) on astragaloside iv biosynthesis was investigated. an intermediate expression vector consisting of the camv35s promoter fused to the vgb and nopaline synthase terminator was transferred into astragalus membranaceus via agrobacterium rhizogenes. the transgenic hairy roots were confirmed by pcr amplification and southern blot hybridization. the expression of vgb in transgenic hairy roots was confirmed by rt-pcr. after 15 days cu ... | 2011 | 21626794 |
| cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia of ganoderma lucidum cultivated in the medium containing leguminous plants on hep 3b cells. | the objective of this study was to investigate the cytotoxicity of the ethanolic extract of mycelia from ganoderma lucidum (emg) cultivated in a medium containing leguminous plants glycine max (l.) merr. and astragalus membranaceus on human hepatocellular carcinoma cells (hep 3b) and to isolate the active components from emg. the results indicated that emg induced cytotoxicity in a dose- and time-dependent manner, and the cells treated with emg for 24, 48, and 72 h had ic(50) values of 156.8, 89 ... | 2009 | 19492810 |
| antifibrotic effect of the chinese herbs modified danggui buxue decoction () on adriamycin-induced nephropathy in rats. | objective: to investigate the antifibrotic effect of the chinese herbs modified danggui buxue decoction (, mdbd) on adraimycin-induced nephropathy in rats. methods: thirty-two male sprague dawley albino rats were randomly divided into 4 groups: the control, model, and two treatment groups, with 8 in each group. nephropathy was induced in the latter 3 groups by intravenous injection of adriamycin. rats in the two treatment groups received intragastric administration of benazepri (a positive contr ... | 2011 | 21805297 |
| the protective action of radix astragalus membranaceus against hapten-induced colitis through modulation of cytokines. | astragalus membranaceus is a medicinal herb with potential immunomodulatory property, which has been used in treating colitis-related diarrhea. in the present investigation, we aimed to further explore its anti-inflammatory activity by studying the immunoregulatory mechanism of astragalus root extract (am) through different routes of administration in hapten-induced colitis. 2,4-dinitrobenzene sulfonic acid (dnbs) was used to induce experimental colitis in sprague-dawley rats. results have indic ... | 2009 | 19539495 |
| saponin fraction from astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein c pathway. | sepsis remains the leading cause of death in intensive care units. uncontrolled systemic inflammation and an impaired protein c pathway are two important contributors to sepsis pathophysiology. based on the beneficial effects of the saponin fraction from astragalus membranaceus roots (sam) against inflammation, liver dysfunction, and endothelium injury, we investigated the potential protective roles and underlying mechanisms of sam on polymicrobial sepsis induced by cecal ligation and puncture ( ... | 2009 | 19548065 |
| in vitro effects of aqueous extracts of astragalus membranaceus and scutellaria baicalensis georgi on toxoplasma gondii. | toxoplasma gondii is a parasite that infects animals and humans worldwide. the standard treatment for toxoplasmosis is limiting due to toxic adverse effects, thus there is a need to identify new drugs that are less toxic. both astragalus membranaceus and scutellaria baicalensis georgi are popular traditional chinese herbs widely used for the treatment of various inflammatory diseases in asia, and we have previously demonstrated that water extracts of a. membranaceus (ame) and s. baicalensis geor ... | 2011 | 22179265 |
| [the protective effect of astragalus membranaceus extraction on cryopreserved primary-cultured human fetal hepatocytes]. | to observe the influence of astragalus membranaceus extraction (ae) on the primary-cultured human fetal hepatocytes stored in liquid nitrogen and explore a new method for the cryopreservation of human hepatocytes with improved function. | 2007 | 18422189 |
| a combination of chinese herbs, astragalus membranaceus var. mongholicus and angelica sinensis, improved renal microvascular insufficiency in 5/6 nephrectomized rats. | chronic renal ischemia and hypoxia in the tubulointerstitium are involved in the mechanisms of progressive chronic kidney disease. previous studies showed that the decoction of a combination of two chinese herbs, astragalus membmnaceus var. mongholicus and angelica sinensis (a & a) has antifibrotic effects through multiple pathways in different animal models. in this study, remnant kidney model was employed to investigate whether a & a affect the expression of vegf, the density of the renal micr ... | 2009 | 19563735 |
| Mesorhizobium silamurunense sp. nov., a novel species nodulated with Astragalus species in China. | Four rhizobial strains representing a previously defined novel group in the genus Mesorhizobium associated with Astragalus species in China were further characterized using a polyphasic approach. Phylogenetic analysis of 16S rRNA gene sequences showed that these Gram-negative bacteria belonged to the genus Mesorhizobium with Mesorhizobium plurifarium LMG 11892T as the closest neighbour sharing a sequence similarity of 99.8%. Polyphasic taxonomic methods including comparative sequence analysis of ... | 2011 | 22058324 |
| astragalus improved cardiac function of adriamycin-injured rat hearts by upregulation of serca2a expression. | the traditional chinese medical herb astragalus, the dried root of astragalus membranaceus (fisch.) bge., has been widely applied to treat patients with cardiovascular disease in china and has profound cardioprotective effects. this study investigated the effect of astragalus on hemodynamic changes in adriamycin (adr)-injured rat hearts and its underlying molecular mechanism. sprague-dawley rats were divided into four groups: control, adr only, adr + low dose of astragalus and adr + high dose of ... | 2009 | 19606512 |
| effect of astragalus membranaceus in rats on peripheral nerve regeneration: in vitro and in vivo studies. | this study provides in vitro and in vivo evaluation of astragalus membranaceus (am) on peripheral nerve regeneration. | 2010 | 20154555 |
| Treatment with Astragalus membranaceus produces antioxidative effects and attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in rats. | Astragalus membranaceus, also known as huang qi, a traditional Chinese medicine, is often used in formulas for deficiency of vital energy characterized by limb weakness, pale face, and dizziness. Previous studies have shown that Astragalus membranaceus could attenuate intestinal ischemia-reperfusion injury induced by hemorrhagic shock in rats; however, the underlying mechanism still remains unclear. Using a hemorrhagic shock rat model to examine the effect of Astragalus membranaceus on intestina ... | 2011 | 21905279 |
| Studies on cell migration model in intestinal epithelial restitution for pharmacological research. | To set up a suitable IEC-6 migration model for pharmacological research and observe the effect of complex polysaccharide from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao to IEC-6 cell migration. | 2011 | 21954562 |
| geodermatophilus ruber sp. nov., isolated from rhizosphere soil of a medicinal plant. | a novel actinobacterial strain, designated cpcc 201356(t), was isolated from a rhizosphere soil sample of the medicinal plant astragalus membranaceus and subjected to a polyphasic taxonomic analysis. good growth occurred at 20-32 °c, at ph 7.0-7.5 and with 0-1 % (w/v) nacl. colonies on r2a and isp 2 agar were light red to red, round and lacked aerial mycelium; cells adhered to the agar. the peptidoglycan contained meso-diaminopimelic acid as the diagnostic diamino acid. the predominant menaquino ... | 2011 | 20190022 |
| astragaloside iv improves homocysteine-induced acute phase endothelial dysfunction via antioxidation. | astragaloside iv, the major active component extracted from astragalus membranaceus, exerts multipotent activities under pathophysiological conditions. hyperhomocysteinemia, an independent risk factor for cardiovascular disease, induces oxidative stress leading to endothelial dysfunction. we investigated the effect of astragaloside iv on acute phase endothelial dysfunction induced by homocysteine. in a concentration-dependent manner, endothelial dysfunction was induced by homocysteine. in organ ... | 2010 | 20410599 |
| [pharmacological action of astragalus membranaceus on the central nervous system in mice]. | | 2010 | 2952357 |
| astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products. | because advanced glycation end product (age) inhibitors such as pyridoxamine significantly inhibit the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with age inhibitors is believed to be a potential strategy for the prevention of lifestyle-related diseases such as diabetic complications. a crude extract of astragali radix (ar; roots of astragalus membranaceus ) inhibits the formation of n(epsilon)-(carboxymethyl)lysine (cml) and pentosidine durin ... | 2009 | 19681610 |
| peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants. | we determined the ability of extracts and active components isolated from nine medicinal plants, poncirus trifoliata, astragalus membranaceus, magnolia obovata, salvia miltiorrhiza, angelica dahurica, cornus officinalis, cnidium officinale, pueraria lobata and ostericum koreanum, to neutralize peroxyl radicals using the total oxyradical scavenging capacity (tosc) assay. peroxyl radicals were generated from thermal homolysis of 2,2'-azobis(2-methylpropionamidine) dihydrochloride, which oxidize al ... | 2010 | 20607491 |
| the protective effects of the traditional chinese herbs against renal damage induced by extracorporeal shock wave lithotripsy: a clinical study. | extracorporeal shock wave lithotripsy (eswl)-induced renal damage can occur as a result of multiple mechanisms. we have reported previously that astragalus membranaceus, salvia miltiorrhiza, a decoction of six drugs containing rhizoma rehmanniae preparata and supplements of a few traditional chinese medicinal herbs for invigorating the kidney and excreting calculus, have a protective effect on renal injury induced by high-energy shock waves (hesw) in rabbits. in this clinical study we further in ... | 2011 | 20607528 |
| the two isomers of hdtic compounds from astragali radix slow down telomere shortening rate via attenuating oxidative stress and increasing dna repair ability in human fetal lung diploid fibroblast cells. | 4-hydroxy-5-hydroxymethyl-[1,3]dioxolan-2,6'-spirane-5',6',7',8'-tetrahydro-indolizine-3'-carbaldehyde (hdtic)-1 and hdtic-2 are two isomers extracted from astragalus membranaceus (fisch) bunge var. mongholicus (bge) hsiao. our previous study had demonstrated that they could extend the lifespan of human fetal lung diploid fibroblasts (2bs). to investigate the mechanisms of the hdtic-induced delay of replicative senescence, in this study, we assessed the effects of these two compounds on telomere ... | 2010 | 19839736 |
| the effects of astragalus membranaceus on repeated restraint stress-induced biochemical and behavioral responses. | astragalus membranaceus (am) is a useful korean herb that has been clinically prescribed for stress-related illness. the objective of the present study was to examine the anti-stress effects of am on repeated stress-induced alterations of anxiety, learning and memory in rats. restraint stress was administered for 14 days (2h/day) and am (400mg/kg) given by oral administration, in the am group, for the same period. starting on the eighth day, the rats were tested for spatial memory on the morris ... | 2009 | 19885016 |
| effect of a novel botanical agent drynol cibotin on human osteoblast cells and implications for osteoporosis: promotion of cell growth, calcium uptake and collagen production. | osteoporosis is a widespread problem afflicting millions of people. drynol cibotinis is a newly developed proprietary botanical combination of eight botanicals including angelica sinensis, glycine max, wild yam, ligustrum lucidum, astragalus membranaceus, cuscuta chinensis, psoraleae corylifoliae, and drynaria fortune. each of the botanicals has been used in traditional chinese medicine to treat osteoporosis. the effect of drynol cibotinis, with the specific combination of these anti-osteoporosi ... | 2010 | 19953582 |
| effect of astragalus membranaceus and angelica sinensis combined with enalapril in rats with obstructive uropathy. | ace inhibitors (acei) reduce renal tubulointerstitial fibrosis but are not completely effective. combined extract of astragalus membranaceus and angelica sinensis (a&a) is a traditional antifibrotic agent in china. the present investigation aimed to determine whether an acei (enalapril) and a&a together have a better antifibrotic effect in unilateral ureteral obstruction (uuo) than monotherapy with either agent. male sprague-dawley rats (n = 4 per group) had either sham operation or uuo alone, w ... | 2010 | 19960445 |
| [effects of inoculating am fungi on physiological characters and nutritional components of astragalus membranaceus under different n application levels]. | a pot culture with unsterilized soil as growth substrate showed that am fungi had significant effects on the growth of astragalus membranaceus (fabaceae) under different n application levels. inoculation with am fungi promoted the am infection of a. membranaceus roots, but high n application level suppressed the infection. inoculating am fungi increased the growth rate, soluble protein and sugar contents, and sod, pod and cat activities of a. membranaceus. under 50 and 100 mg x kg(-1) of n appli ... | 2009 | 20030131 |
| [ecological environment of cultivated astragali radix and market specification of prepared slices]. | astragali radix is derived from roots of astragalus membranaceus var. mongholicus and a. membranaceus. the exhaustion of wild astragali radix has made cultivated astragali radix possess the commercial market of astragali radix. so the ecological environment of cultivated astragali radix should be investigated through field survey. through investigation, we found that a. membranaceus var. mongholicus are cultivated in hengshan mountain of shanxi province, longnan of gansu province, south of inner ... | 2010 | 20707062 |
| formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the erk and p38 mapk pathways. | formononetin, a phytoestrogen from the root of astragalus membranaceus, is used as a blood enhancer and to improve blood microcirculation in complementary and alternative medicine. the present study investigated the influence of formononetin on the expression of early growth response factor-1 (egr-1) and growth factors contributing to wound healing. formononetin significantly increased growth factors such as transforming growth factor-beta 1 (tgf-β1), vascular endothelial growth factor (vegf), p ... | 2010 | 20959155 |
| the herbal formula ht042 induces longitudinal bone growth in adolescent female rats. | the effect of ht042, a blend of three herbal extracts, on longitudinal bone growth was investigated in short- and long-term rat models. in the short-term model, we divided female sprague-dawley rats (3 weeks old) into six groups, according to treatment: vehicle, ht042 (100 mg/kg), phlomis umbrosa (100 mg/kg), astragalus membranaceus (100 mg/kg), and eleutherococcus senticosus (100 mg/kg) were administered twice daily, and recombinant human growth hormone (rhgh) (1 iu) was subcutaneously injected ... | 2010 | 21091251 |
| [effects of astragalus heteropolysaccharides on erythrocyte immune adherence function of mice with adjuvant-induced arthritis]. | astragalus heteropolysaccharides (ahps) is obtained from the dried roots of astragalus membranaceus (fisch.) bunge var. mongholious (bunge) hsiao. in the present study, we observed its effects on erythrocyte immune adherence function in mice with adjuvant-induced arthritis (aa). the mice were treated intragastrically with ahps of 1 000, 500, and 250 mg x kg(-1) x d(-1) separately and treated with tripterygium glycosides (tg) of 60 mg x kg(-1) x d(-1) as positive control. the number of complement ... | 2009 | 21351470 |
| [protective effects of astragalus membranaceus on free fatty acid-induced vascular endothelial cell dysfunction]. | to investigate whether astragalus membranaceus (am) can protect endothelium-dependent vasodilatation (edv) function of aorta from the damage induced by high level of free fatty acid (ffa). | 2011 | 21355300 |
| ensifer shofinae sp. nov., a novel rhizobial species isolated from root nodules of soybean (glycine max). | two bacterial strains isolated from root nodules of soybean were characterized phylogenetically as members of a distinct group in the genus ensifer based on 16s rrna gene comparisons. they were also verified as a separated group by the concatenated sequence analyses of reca, atpd and glnii (with similarities ≤93.9% to the type strains for defined species), and by the average nucleotide identities (ani) between the whole genome sequence of the representative strain ccbau 251167(t) and those of th ... | 2017 | 28209394 |
| astragalus membranaceus extract promotes neovascularisation by vegf pathway in rat model of ischemic injury. | astragalus membranaceus extract (ame) is a widely used herbal product for the treatment of cardiovascular diseases in china. the present study aimed to evaluate the cardiac protective effects of ame, and to probe the underlying molecular mechanism related to angiogenesis. in this study, ame with 75 microg/ml significantly increased proliferation, migration and tube formation on human umbilical vein endothelial cells (huvecs). moreover, in vivo experiments on rats with ligation of left anterior d ... | 2011 | 21434579 |
| rt-qpcr analysis of dexb and gale gene expression of streptococcus alactolyticus in astragalus membranaceus fermentation. | streptococcus alactolyticus strain fgm, isolated from chicken cecum, was used to increase the extract yield of polysaccharides during astragalus membranaceus fermentation. it was previously demonstrated that polysaccharides from fermented a. membranaceus by s. alactolyticus had some similar properties to those from a. membranaceus in terms of its ability to help heal hepatic fibrosis in rats and modulate immunopotentiation of broiler chicken. however, methods to increase the yield of the polysac ... | 2013 | 23563988 |
| [effects of atovaquone and astragalus combination on the treatment and il-2, il-12, ifn-γ levels on mouse models of acute toxoplasmosis]. | reactivation of toxoplasma gondii infections and serious clinical manifestations such as encephalitis may develop in immunocompromised subjects and aids patients. different protocols are used for the treatment of toxoplasmosis in high-risk patient groups, however life-long prophylactic therapy against reactivation risk in aids patients may lead to several undesired results. atovaquone is an effective antiprotozoal agent against toxoplasmosis with minor side effects. on the other hand, astragalus ... | 2014 | 25492659 |
| molecular cloning, characterization and expression of a chalcone reductase gene from astragalus membranaceus bge. var. mongholicus (bge.) hsiao. | a chalcone reductase (chr) gene was isolated from astragalus membranaceus bge. var. mongholicus (bge.) hsiao (a. mongholicus). the full-length cdna of a. mongholicus chr, designated as amchr (genbank accession no. hm357239), was 1196 bp long. it had a 957 bp open reading frame encoding a 318-amino acid protein of 35 kda, a 67 bp 5' non-coding region and a 172 bp 3'-untranslated region. the putative amchr protein showed striking similarity to chr from other leguminous species. two-dimensional str ... | 2011 | 21647549 |
| a ten-year audit of traditional chinese medicine and other natural product research published in the chinese medical journal (2000-2009). | clinical research encompasses a wide variety of disciplines. traditional chinese medicine (tcm) and natural product research have made great contributions to preventing and treating illness. the number and content of original research reports evaluating tcm and natural products have not previously been described. information in this area will identify areas of relative strength and weakness in terms of knowledge gaps with respect to clinical conditions and natural product remedies. | 2011 | 21740755 |
| global transcriptome analysis profiles metabolic pathways in traditional herb astragalus membranaceus bge. var. mongolicus (bge.) hsiao. | astragalus membranaceus bge. var. mongolicus (bge.) hsiao (a. mongolicus, family leguminosae) is one of the most important traditional chinese herbs. among many secondary metabolites it produces, the effective bioactive constituents include isoflavonoids and triterpene saponins. the genomic resources regarding the biosynthesis of these metabolites in a. mongolicus are limited. although roots are the primary material harvested for medical use, the biosynthesis of the bioactive compounds and its r ... | 2015 | 26099797 |
| protection of chinese herbs against adenine-induced chronic renal failure in rats. | the aim of the study is to evaluate the efficacy of chinese herbs (angelica sinensis, ligusticum wallichii, salvia miltiorrhiza, rhizoma dioscoreae, rhodiola crenilata, astragalus membranaceus and angelica sinensis) on adenine-induced chronic renal failure in rats. 30 age-matched male wistar rats were divided into three groups. rats in group a (n = 10), b (n = 10) and c (n = 10) were fed a standard laboratory chow and allowed tap water ad libitum. in group b and c, renal failure was induced by t ... | 2010 | 21731165 |
| a standardized extract from paeonia lactiflora and astragalus membranaceus attenuates liver fibrosis induced by porcine serum in rats. | paeonia lactiflora and astragalus membranaceus are two popular traditional chinese medicines, commonly used in chinese herb prescription to treat liver disease. the extract prepared from the roots of paeonia lactiflora and astragalus membranaceus (pae) demonstrated better hepatoprotective activity than the herbs used individually as shown in our previous studies. this study was carried out to investigate the effects of pae on liver fibr ... | 2011 | 22109673 |
| Danggui Buxue Tang attenuates eosinophil infiltration and airway hyperresponsiveness in asthmatic mice. | Danggui Buxue Tang (DBT), an herbal formula containing Angelica sinensis (AS) and Astragalus membranaceus (AM) (AS:AM = 1:5, designated as DBT1 here), has been used in Chinese medicine to enhance qi and blood circulation. In addition, DBT has served as a treatment for atopic dermatitis in dogs in Taiwan. It also may improve fibrosis in a rat model of pulmonary fibrosis. | 2011 | 22123379 |
| astragalus membranaceus lectin (aml) induces caspase-dependent apoptosis in human leukemia cells. | objectives: recently, plant lectins have attracted great interest due to their various biological activities such as anti-cancer, anti-fungal and anti-viral activities. we have reported earlier concerning anti-proliferation of human cancer cell lines by a galactose-binding lectin (aml), from a chinese herb, astragalus membranaceus. in the present study, detailed investigations into the mechanism of such anti-proliferation properties have been carried out. materials and methods: mechanism of ap ... | 2011 | 22172162 |
| protective effect of astragaloside iv against matrix metalloproteinase-1 expression in ultraviolet-irradiated human dermal fibroblasts. | ultraviolet (uv) irradiation induces skin photoaging associated with up-regulated matrix metalloproteinase (mmp) expression. inhibition of mmp expression is suggested to alleviate photoaging induced by uv irradiation. astragaloside iv (as-iv), one of the main active ingredients of astragalus membranaceus (fisch) bge, has been reported to have various biological activities. however, its anti-photoaging effect has not been examined to date. in the present study, we observed the effect of as-iv on ... | 2011 | 21975818 |
| astragalus saponins modulate cell invasiveness and angiogenesis in human gastric adenocarcinoma cells. | aim of the study: we had reported that astragalus saponins (ast) exert promising anti-tumorigenic effects by suppressing the growth of ht-29 human colon cancer cells and tumor xenograft. in the present study, we further investigated the anti-angiogenic property of ast in human gastric adenocarcinoma cells (ags) and attempted to elucidate the underlying mechanism. materials and methods: viability of ags cells was measured by using the mtt reduction method. western blotting was performed to examin ... | 2011 | 21864667 |
| astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting nf-κв activation. | astragalus polysaccharide (aps) is a bioactive extract of astragalus membranaceus (am), which possess a wide range of medicinal benefits, including anti-inflammatory, anti-oxidative, anti-tumor and anti-diabetic effects. the present work evaluated the therapeutic effect of aps and its potential mechanisms in a mouse model of dextran sulfate sodium (dss)-induced colitis. the aps treatment led to significant improvements in colitis disease activity index (dai) and histological scores, as well as s ... | 2017 | 28188801 |
| formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of mir-21 and pten. | the isoflavone formononetin is the main active component of astragalus membranaceus and possesses anti-tumorigenic properties. however, the role of formononetin in human bladder cancer (bca) has not been fully elucidated. the aim of the present study was to investigate the anti-tumor effects of formononetin on bca cells and its potential molecular mechanism. t24 cells were treated with different concentrations of formononetin, and then the cell proliferation was assessed by mtt assay, cell apopt ... | 2017 | 28139790 |
| chinese herbal drugs for the treatment of diabetic retinopathy. | to explore the various pharmacological actions and the molecular mechanisms behind them by which chinese herbs tend to lower the risk of developing microvascular diabetic complications in retina and prevent its further progression. | 2017 | 28124440 |
| therapeutic effects of qian-yu decoction and its three extracts on carrageenan-induced chronic prostatitis/chronic pelvic pain syndrome in rats. | qian-yu decoction (qyd) is a traditional chinese medicinal recipe composed of radix astragali (astragalus membranaceus (fisch.) bunge var. mongholicus (bunge) p.k. hsiao, fabaceae ), herba epimedii (epimedium brevicornum maxim., berberidaceae), herba leonuri (leonurus japonicus houtt., lamiaceae), cortex phellodendri (phellodendron chinense schneid., rutaceae) and radix achyranthis bidentatae (achyranthes bidentata bl., amaranthaceae). this study aimed to evaluate the therapeutic activity of qyd ... | 2017 | 28122556 |
| astragalus extract attenuates allergic airway inflammation and inhibits nuclear factor κb expression in asthmatic mice. | background:: astragalus membranaceus from traditional chinese herbal medicines previously showed that it possesses a strong anti-inflammatory activity. the purpose of this study was to elucidate the effect of astragalus on allergen-induced airway inflammation and airway hyperresponsiveness and investigate its possible molecular mechanisms. methods:: female balb/c mice sensitized and challenged with ovalbumin (ova) developed airway inflammation. bronchoalveolar lavage fluid was assessed for total ... | 2012 | 23267235 |
| [primary research on the clinical significance of ventricular late potentials (vlps), and the impact of mexiletine, lidocaine and astragalus membranaceus on vlps]. | the body surface signal-averaged electrocardiogram (saecg) was recorded on 316 cardiac patients, 84% (266 patients) of whom were also taken 24-hour holter ecg. vlps were detected positively in 6.1%, 25%, 25.7%, 14.3% and 5.5% of patients with angina pectoris, myocardial infarction, myocarditis, cardiomyopathy and arrhythmia of unknown origin respectively, and the patients with complex ventricular arrhythmia had more vlps positive determination definitely (p less than 0.05). the specificity of vl ... | 1977 | 1879028 |
| low-cost magnetic herbal biochar: characterization and application for antibiotic removal. | magnetic biochar (m-bc) was derived from herbal medicine waste, astragalus membranaceus residue, and was used as an adsorbent for ciprofloxacin removal from aqueous solutions. the m-bc was characterized by brunauer-emmett-teller surface area analyses, fourier transform infrared spectrometry, x-ray diffraction analysis, hysteresis loops, scanning electron microscopy energy-dispersive spectrometry, and x-ray photoelectron spectroscopy. the bet surface area increased from 4.40 to 203.70 m(2)/g afte ... | 2017 | 28083746 |
| treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction. | | 2013 | 3807414 |
| regulation of inflammatory gene expression in pbmcs by immunostimulatory botanicals. | many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. while there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy of these botanicals, limited scientific evidence exists on the ability of these botanicals to modulate the immune and inflammatory responses. using botanogenomics (or herbogenomics), this study provides novel insight into inflammatory genes which ar ... | 2010 | 20838436 |
| comparison of the anti-duck hepatitis a virus activities of phosphorylated and sulfated astragalus polysaccharides. | duck hepatitis a virus (dhav) (picornaviridae) causes an infectious disease in ducks which results in severe losses in duck industry. however, the proper antiviral supportive drugs for this disease have not been discovered. polysaccharide is the main ingredient of astragalus that has been demonstrated to directly and indirectly inhibit rna of viruses replication. in this study, the antiviral activities of astragalus polysaccharide (aps) and its derivatives against dhav were evaluated and compare ... | 2017 | 27703041 |
| astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity. | doxorubicin (adriamycin), an anthracycline antibiotic, is commonly used to treat many types of solid and hematological malignancies. unfortunately, clinical usage of doxorubicin is limited due to the associated acute and chronic cardiotoxicity. previous studies demonstrated that astragalus polysaccharide (aps), the extracts of astragalus membranaceus, had strong anti-tumor activities and anti-inflammatory effects. however, whether aps could mitigate chemotherapy-induced cardiotoxicity is unclear ... | 2017 | 27902477 |
| ameliorating effect of erxian decoction combined with fructus schisandrae chinensis (wu wei zi) on menopausal sweating and serum hormone profiles in a rat model. | modified erxian decoction (mexd), i.e., erxian decoction (exd) with fructus schisandrae chinensis (wu wei zi) added, has been used to alleviate menopausal symptoms. this study aimed to investigate the effects of mexd on menopausal sweating and serum hormone levels in a rat model of menopause after oral administration of mexd. | 2016 | 27895702 |
| astragalus polysaccharide suppresses 6-hydroxydopamine-induced neurotoxicity in caenorhabditis elegans. | astragalus membranaceus is a medicinal plant traditionally used in china for a variety of conditions, including inflammatory and neural diseases. astragalus polysaccharides are shown to reduce the adverse effect of levodopa which is used to treat parkinson's disease (pd). however, the neuroprotective effect of astragalus polysaccharides per se in pd is lacking. using caenorhabditis elegans models, we investigated the protective effect of astragalan, an acidic polysaccharide isolated from a. memb ... | 2016 | 27885333 |
| astragaloside iv from astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via tlr4/nf-кb in vivo and in vitro. | renal fibrosis is characterized by infiltration of inflammatory cells, activation and proliferation of fibroblasts, and accumulation of extracellular matrix (ecm). astragalus membranaceus (am) is traditional chinese medicine and has a range of pharmacological effects. astragaloside iv (as iv) is the main compound of am and has anti-inflammation activities. whether as iv ameliorates renal interstitial fibrosis by inhibiting inflammation remains unknown. accordingly, this study investigated the am ... | 2017 | 27855303 |
| neuroprotective effect of a novel chinese herbal decoction on cultured neurons and cerebral ischemic rats. | historically, traditional chinese medicine has been widely used to treat stroke. based on the theory of chinese medicine and the modern pharmacological knowledge of herbal medicines, we have designed a neuroprotective formula called post-stroke rehabilitation (psr), comprising seven herbs - astragalus membranaceus (fisch.) bunge, salvia miltiorrhiza bunge, paeonia lactiflora pall., cassia obtusifolia l., ligusticum chuanxiong hort., angelica sinensis (oliv.) diels, and glycyrrhiza uralensis fisc ... | 2016 | 27814708 |
| astragalus saponins modulate mtor and erk signaling to promote apoptosis through the extrinsic pathway in ht-29 colon cancer cells. | we have previously demonstrated that the total saponins of astragalus membranaceus (ast) possess potential anti-tumorigenic effects in human colon cancer cells and tumor xenografts. in the present study, the proapoptotic effects of ast were investigated in native and cytokine-induced ht-29 cells to further unveil its mechanism of action. growth-inhibitory action of ast (60 microg/ml) was demonstrated in native ht-29 cells, which was exaggerated in tumor necrosis factor (tnf) (5 ng/ml)-induced ce ... | 2010 | 20664949 |
| structural characterization of low molecular weight polysaccharide from astragalus membranaceus and its immunologic enhancement in recombinant protein vaccine against systemic candidiasis. | structure and immunologic enhancement of low molecular weight polysaccharide (lmw-asp) isolated from the root of astragalus membranaceus (fisch) bge. were detected in recombinant protein vaccine. structure analysis of lmw-asp revealed that lmw-asp (mw=5.6kda) was an acid heteropolysaccharide, which consisted of glc, gal, ara, xyl and gala in ratio of 10.0：1.3：1.7：1.0：0.9. recombinant protein (rp-hsp90c) contained epitope c (lkvirk) from heat shock protein 90 (hsp90) of candida albicans was used ... | 2016 | 27106150 |
| effects of astragalus membranaceus, codonopsis pilosula and allicin mixture on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. | a 12-week trial with 120 [(landrace×yorkshire)×duroc] pigs (45.65 ± 1.93 kg) was conducted to evaluate the effects of astragalus membranaceus, codonopsis pilosula and allicin mixture (hm) supplementation on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. pigs were allocated to one of three treatments with 0, 0.025% (hm1) and 0.05% (hm2) hm supplementation in a randomized complete block design according to sex and bw. each ... | 2016 | 27868250 |
| structural characterization and evaluation of the antioxidant activity of phenolic compounds from astragalus taipaishanensis and their structure-activity relationship. | eight phenolic compounds were isolated using bio-guided isolation and purified from the roots of astragalus taipaishanensis y. c. ho et s. b. ho (a. taipaishanensis) for the first time. their structures were elucidated by esi-ms, hr-esi-ms, 1d-nmr and 2d-nmr as 7,2'-dihydroxy-3',4'-dimethoxy isoflavan (1), formononetin (2), isoliquiritigenin (3), quercetin (4), kaempferol (5), ononin (6), p-hydroxybenzoic acid (7) and vanillic acid (8). six flavonoids (compounds 1-6) exhibited stronger antioxida ... | 2015 | 26350974 |
| formononetin, an active compound of astragalus membranaceus (fisch) bunge, inhibits hypoxia-induced retinal neovascularization via the hif-1α/vegf signaling pathway. | it has been reported that formononetin (fmn), one of the main ingredients from famous traditional chinese medicine "huang-qi" (astragalus membranaceus [fisch] bunge) for qi-tonifying, exhibits the effects of immunomodulation and tumor growth inhibition via antiangiogenesis. furthermore, a. membranaceus may alleviate the retinal neovascularization (nv) of diabetic retinopathy. however, the information of fmn on retinal nv is limited so far. in the present study, we investigated the effects of fmn ... | 2016 | 27729769 |
| astragaloside iv ameliorates necrotizing enterocolitis by attenuating oxidative stress and suppressing inflammation via the vitamin d3-upregulated protein 1/nf-κb signaling pathway. | astragaloside iv (as-iv) is a flavonoid from the plant astragalus membranaceus (fisch) bge that has a wide range of therapeutic effects. the aim of the present study was to examine the effect of as-iv on rats with necrotizing enterocolitis (nec) under oxidative stress and inflammation. newborn sprague-dawley rats were induced with nec by asphyxia and hypothermia applied on 3 consecutive days. the rats were orally administered as-iv at 25, 50 and 75 mg/kg for 4 days. the results revealed that as- ... | 2016 | 27698775 |
| post-hematopoietic stem cell transplantation in patients with hematologic disorders: chinese herbal medicine for an unmet need. | while much progress has been made in the field of hematopoietic stem cell transplantation (hsct), headway in the promotion of recovery following this procedure has been limited. data regarding the potential of chinese herbal medicine (chm) for patients with hematologic disorders who received hsct are gradually increasing; however, these data are mostly in chinese. therefore, we set out to summarize the existing data. we searched pubmed, the cochrane library and the china national knowledge infra ... | 2016 | 27641605 |
| astragalus polysaccharide attenuated iron overload-induced dysfunction of mesenchymal stem cells via suppressing mitochondrial ros. | bone marrow-derived mesenchymal stem cells (bmscs) have the ability to differentiate into multilineage cells such as osteoblasts, chondrocytes, and cardiomyocytes. dysfunction of bmscs in response to pathological stimuli participates in the development of diseases such as osteoporosis. astragalus polysaccharide (aps) is a major active ingredient of astragalus membranaceus, a commonly used anti-aging herb in traditional chinese medicine. the aim of this study was to investigate whether aps protec ... | 2016 | 27607448 |
| suppressive effect of formononetin on platelet-derived growth factor-bb-stimulated proliferation and migration of vascular smooth muscle cells. | abnormal proliferation and migration of vascular smooth muscle cells (vsmcs) has been implicated in intimal hyperplasia, atherosclerosis and restenosis following percutaneous coronary intervention. formononetin, a phytoestrogen extracted from the root of astragalus membranaceus, has been widely used in chinese tradition medicine due to its protective effects against certain symptoms of cancer, hypertension, inflammation, hypoxia-induced cytotoxicity and ovariectomy-induced bone loss. however, th ... | 2016 | 27588108 |
| research review on the pharmacological effects of astragaloside iv. | astragalus membranaceus bunge has been used to treat numerous diseases for thousands of years. as the main active substance of astragalus membranaceus bunge, astragaloside iv (as-iv) also demonstrates the potent protective effect on focal cerebral ischemia/reperfusion, cardiovascular disease, pulmonary disease, liver fibrosis, and diabetic nephropathy. based on studies published during the past several decades, the current state of as-iv research and the pharmacological effects are detailed, elu ... | 2017 | 27567103 |
| astragaloside iv attenuates inflammatory reaction via activating immune function of regulatory t-cells inhibited by hmgb1 in mice. | high-mobility group box 1 (hmgb1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory. some experiments have demonstrated a vital role for hmgb1 to modulate the immune function of regulatory t-cells (tregs). astragaloside iv (ast iv), an extract from astragalus membranaceus moench (leguminosae), has been shown to exert potent cardioprotective and anti-inflammatory effects. it is still unclear whether ast iv has a latent effect on the proinflammatory ability of ... | 2016 | 27564970 |
| astragalus polysaccharides enhance immune responses of hbv dna vaccination via promoting the dendritic cell maturation and suppressing treg frequency in mice. | astragalus polysaccharides (aps), an extract from a kind of chinese traditional herb astragalus membranaceus, was proved to have strong immunoregulatory properties. in this study, aps was employed as an adjuvant of hepatitis b virus (hbv) dna vaccine (pcds2) and its' effects on immune system of mice were investigated. our data demonstrated that aps as an adjuvant could increase the hbsag-specific antibody level as well as the proliferating activity of t cells. aps also could induce cd4(+) t cell ... | 2012 | 23006659 |
| the effect of astragalus polysaccharide on the epstein-barr virus lytic cycle. | effects of a polysacharide from chinese herbal plant astragalus membranaceus (aps) on the expression of epstein-barr virus (ebv) immediate early proteins zta, rta and ea-d in raji cells were examined. ebv switch from latent to lytic cycle in raji cells was induced by 12-o-tetradecanoylphorbol-13-acetate (tpa) and sorbol butyrate (sb) and the effects of aps were examined by immunofluorescence, western blotting and flow cytometry. aps in a non-cytotoxic concentration of 30 μg/ml significantly supp ... | 2014 | 24717032 |
| genetic diversity and distribution of rhizobia associated with the medicinal legumes astragalus spp. and hedysarum polybotrys in agricultural soils. | with the increasing cultivation of medicinal legumes in agricultural fields, the rhizobia associated with these plants are facing new stresses, mainly from fertilization and irrigation. in this study, investigations on the nodulation of three cultivated medicinal legumes, astragalus mongholicus, astragalus membranaceus and hedysarum polybotrys were performed. bacterial isolates from root nodules of these legumes were subjected to genetic diversity and multilocus sequence analyses. in addition, t ... | 2016 | 26915496 |
| deacetylation biocatalysis and elicitation by immobilized penicillium canescens in astragalus membranaceus hairy root cultures: towards the enhanced and sustainable production of astragaloside iv. | a novel biotechnology approach by combining deacetylation biocatalysis with elicitation of immobilized penicillium canescens (ipc) in astragalus membranaceus hairy root cultures (amhrcs) was proposed for the elevated production of astragaloside iv (ag iv). the highest ag iv accumulation was achieved in 36-day-old amhrcs co-cultured with ipc for 60 h, which resulted in the enhanced production of ag iv by 14.59-fold in comparison with that in control (0.193 ± 0.007 mg/g dw). meanwhile, ag iv precu ... | 2017 | 27518481 |
| effects of astragalus polysaccharides on memory impairment in a diabetic rat model. | astragalus polysaccharides (aps) are active constituents of astragalus membranaceus. in this study, we aimed to investigate the effects of aps on memory impairment in a diabetic rat model and their mechanisms. | 2016 | 27445477 |
| effects of jin-ying-tang on staphylococcus aureus-induced mastitis in rabbit. | the present study was performed to investigate the effects of jin-ying-tang (jyt), a chinese herbal formula containing lonicera japonica, herba taraxaci, fructus trichosanthis, fructus forsythia, radix et rhizoma rhei, astragalus membranaceus, angelica sinensis, on rabbit mastitis induced by staphylococcus aureus. suckling rabbits were challenged with 1.5 × 10(7) colony forming unit (cfu) of s. aureus at the base of the third pair teats, and they were treated and pretreated with jyt to detect th ... | 2012 | 22303901 |
| first report of fingerprinting dried herbal products using a subtractive diversity array. | introduction sequence - independent microarrays have never been used to identify and authenticate dried herbal plants. | 2013 | 23828332 |
| simultaneous determination of six active metabolites in astragalus mongholicus (fisch.) bge. under salt stress by ultra-pressure liquid chromatography with tandem mass spectrometry. | astragalus membranaceus bge. var. mongholicus (bge.) hsiao (a. mongholicus, family leguminosae) is one of the most important traditional chinese herbs because it contains lots of bioactive metabolites, which have beneficial and pharmacological effects on health. simultaneously, it has been proved to be a salt-tolerant plant-one of the potential species to control the soil salinization. therefore, a sensitive and specific ultra-pressure liquid chromatography coupled with tandem mass spectrometric ... | 2016 | 27386371 |
| a standardized composition from extracts of myristica fragrans, astragalus membranaceus, and poria cocos protects liver from acute ethanol insult. | despite the promising advances in therapeutic discovery, there still is a major challenge in the development of a safe, effective, and economical intervention for managing alcohol-related liver disorders. in this study, we describe the potential use of "map," a standardized composition comprising three extracts from myristica fragrans, astragalus membranaceus, and poria cocos, in ameliorating alcohol-induced acute liver toxicity. ethanol-induced acute hepatotoxicity as an animal model of binge d ... | 2016 | 27355692 |
| degradation of phenanthrene and pyrene in rhizosphere of grasses and legumes. | phytoremediation is an emerging technology for the remediation of organic soil pollutants such as phenanthrene and pyrene (polycyclic aromatic hydrocarbons, pahs). the pah degradation ability of four native korean plant species (panicum bisulcatum, echinogalus crus-galli, astragalus membranaceus, and aeschynomene indica) was compared in the greenhouse. during the 80-day experiment, soil samples were collected and analyzed periodically to determine the residual pah content and microbial activity. ... | 2008 | 17959304 |