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[immunofluorescence with the pi-3 virus--study of various working conditions for the detection of viral infection using immunofluorescence on various types of cell cultures].we used the fluorescence method for the investigation of the sensitivity of several kinds of cell cultures to the infection with the parainfluenza virus 3 (pi-3). cultures from calf kidneys were the most sensitive while we did not determine any differences between primary cultures and cultures of the first and second subpassages and/or freshly cultivated or incubated cultures over seven days at a temperature of 37 degrees c. equal values of infection titres like on the cultures of calf kidneys w ...1978208220
glycoproteins of representative paramyxoviruses: isolation and antigenic analysis using a zwitterionic surfactant. 1978209128
viral eye diseases. 1977209512
neutralising antibodies to parainfluenza 3 virus in african wildlife, with special reference to the cape buffalo (syncerus caffer).as part of a study to assess the prevalence of common viral agents in african wildlife, nearly 3,300 sera from 44 different wild species, from eight african countries, have been examined for neutralising antibodies to parainfluenza 3 (pi3) virus. antibody was demonstrated in 20 of the 44 species examined, including seven species not previously reported as sero-positive. sera were collected between 1963 and 1977 and results indicated that infection has been widespread for a considerable time. the ...1978211274
parainfluenza virus type 3: isolation from csf of a patient with guillain-barré syndrome.we report the isolation of parainfluenza virus type 3 from the csf of a 19-year-old man with guillain-barré syndrome. although parainfluenza viruses are usually associated with respiratory tract illnesses, some strains show a neurotropism not previously appreciated. thus, parainfluenza viruses may be responsible for a portion of cases of guillain-barré syndrome.1978211275
[role of parainfluenza viruses rs and adenoviruses as well as mycoplasma pneumoniae in acute respiratory infections in infants]. 1978211553
viral etiology of multiple sclerosis. 1978212783
virus morbidum foetus. congenital malformations and neonatal infections. 1978214500
parainfluenza-3 virus: difference in capacity of neuraminidase-weak and strong strains to infect young calves and to elicit cellular immune response.calves less than four weeks old could not be infected with a neuraminidase-weak strain of parainfluenza-3 virus (pi3) but were successfully infected with either of two neuraminidase-strong strains. the criteria for infection were virus excretion, cell-mediated and antibody-mediated immune responses. in the lymphocyte stimulation test, calves infected with the neuraminidase-strong pi3 strain tüb-e6 responded more strongly to antigen prepared from this strain than to antigen from the heterologous ...1978214834
studies on the pathogenicity of human-origin parainfluenza virus in the brain of mice.the pathogenicity of parainfluenza type 2 (croup-associated) virus known to cause infections of the respiratory tract in the early life of man was studied in the brain of mice. one- to 4-day-old sucklings and 4-week-old mice were inoculated intracerebrally with the virus. the virus multiplied in sucklings, but not in adults. most mice inoculated intracerebrally with the virus appeared healthy. histological examination showed minimum inflammatory changes, although moderate hydrocephalus developed ...1978215882
[treatment of children with the croup syndrome in various acute respiratory viral diseases]. 1978216146
[virological studies of acute respiratory syndromes in 1975--1976]. 1978216321
reactivities of systemic lupus erythematosus sera with cellular and virus antigen preparations.sera of patients with systemic lupus erythematosus (sle) showed significantly higher complement fixation reactivities with 8 of 10 virus antigen preparations compared to sera of normal subjects, including virus workers, confirming earlier observations. however, one-third of sle sera were also reactive with cellular antigens, prepared in a manner identical to viral antigens, but from cells not infected with virus. by contrast, only one of 49 normal sera showed reactivity with one of nine cellular ...1978216373
[epidemiological estimation of infections caused by viruses of influenza, rs viruses and adenoviruses in hospitalized children]. 1979218159
[clinical manifestations of viremia during infections caused by adenoviruses and parainfluenza viruses]. 1979218160
[inflammatory diseases of the respiratory system during infections caused by aprainfluenza, rs viruses and adenoviruses]. 1979218161
the occurrence of antibodies to parainfluenza3 virus in sera of some domestic animals of the sudan. 1979218672
canine kidney cell line for isolation of respiratory viruses.by means of a continuous canine kidney cell line (mdck), influenza viruses were rapidly isolated from specimens collected from patients with respiratory disease. the cell line proved more sensitive than either eggs or rhesus monkey cells for currently circulating influenza a and b strains. influenza viruses caused a distinct cytopathology within 5 days of inoculation if trypsin-ethylenediamine-tetraacetic acid was incorporated into the medium. sufficient hemagglutinin was produced on the initial ...1979219021
respiratory viruses in hospital patients on the witwatersrand. a 7-year study.virological investigations were carried out on 4 151 patients with respiratory disease hospitalized between may 1966 and april 1972. the groups examined were black and white children and black miners. influenza viruses were more common among malnourished black children and tended to cause more severe disease. this was also true of adenovirus and herpesvirus hominis type 1 infections. adenoviruses appear to be secondary invaders, frequently after a measles or influenza attack. a generalized epide ...1979219551
observations on outbreaks of respiratory disease in calves associated with parainfluenza type 3 virus and respiratory syncytial virus infection.in four outbreaks of indoor calf pneumonia, dyspnoea was a prominent clinical finding. at necropsy it was associated with pneumonia involving the cranial lobes of the lung and severe pulmonary emphysema. histological examination of lung tissue revealed bronchiolitis and alveolitis with alveolar epithelial cell hyperplasia and multinucleate syncytium formation. intraalveolar haemorrhage, intra-alveolar oedema and hyaline membrane formation were also noted. in all cases parainfluenza type 3 (pi3) ...1979219584
studies of respiratory disease in random-source laboratory dogs: viral infections in unconditioned dogs.a prospective study was conducted to identify the viruses causing respiratory diseases in unconditioned, random-source dogs. during the quarantine period, respiratory disease occurred in 86 of 167 (52%) dogs, and 34 (21%) died. most affected dogs had a distemper-like illness which required extensive and prolonged care. histopathologic studies confirmed the diagnosis of canine distemper in 10 of 12 (83%) fatal infections examined. sixty-seven of 91 (74%) dogs which arrived without canine distempe ...1979220463
respiratory viral infection and wheezy bronchitis in childhood.the role of respiratory viral infection in wheezy bronchitis was studied in 163 children, aged 0-12 years, in a london general practice. virological investigations were also performed when these same children had acute upper respiratory illness without wheeze. a virus was isolated in 146 (26.4%) of 554 episodes of wheezy bronchitis, rhinoviruses accounting for almost half of the isolations. the relative frequency with which individual viruses were isolated in wheezy bronchitis was similar to tha ...1979220747
fluorescence polarization of dph-labeled cells adsorbing viruses and its diagnostic potential.mammalian or avian cells were labeled with a fluorescent probe dph (1,6-diphenyl-1,3,5-hexatriene). within a few minutes after adsorption of various naked and enveloped viruses, the degree of fluorescence polarization (p) of the dph embedded in the adsorbing cells as measured at 37 degrees c, was reduced, a finding indicating a decrease in the microviscosity of the lipids in the cell membrane. this change of fluidity was proportional to the concentration of the adsorbing virus and could be aboli ...1979222236
comparison of cynomolgus and rhesus monkey kidney cells for recovery of viruses from clinical specimens.in a study of virus recovery from clinical specimens, cynomolgus monkey kidney cells demonstrated sensitivity equivalent or slightly superior to rhesus kidney cells for siolation of myxo- and paramyxoviruses, adenoviruses, and enteroviruses.1979222808
[role of parainfluenza varuses in etiology of acute respiratory infections in children (serological diagnosis)].serologic investigations carried out in 254 children admitted to a clinic for children for respiratory diseases, established a diagnosis of infection with parainfluenza virus in 19.2% of cases. the predominant age-group affected was 7--12 months and 0--6 months; the causative agent in most cases was parainfluenza type 3, followed by type 2 and then type 1. the role of parainfluenza viruses in the aetiology of laryngotracheobronchiectasis was confirmed, as well as their participation in the aetio ...1979223218
serological evidence of infectious bovine rhinotracheitis, bovine virus diarrhoea and parainfluenza-3 viruses in calves in el salvador. 1979223256
clinical significance of pulmonary function tests. alterations in pulmonary function following respiratory viral infection.respiratory viral illness is a major cause of morbidity in both adults and children. this report focuses on both the acute and chronic effects on respiratory function of these ubiquitous infections. infant airways are particularly vulnerable due to the relatively low conductance in immature peripheral airways. bronchiolitis, caused predominantly by respiratory syncytial virus, is the most important of these viral illnesses and is emerging as a major risk factor for the subsequent development of ...1979225132
[epidemiology of infections and diseases caused by parainfluenza, rs and adenoviruses in 4 state children's homes]. 1979225760
[pressing problems of acute respiratory viral diseases in children]. 1979225874
aerosol stability of bovine parainfluenza type 3 virus.aerosols of bovine parainfluenza type 3 virus were generated with a devilbiss 40 nebulizer from eagle's minimum essential medium and nasal secretion from a non-infected calf and stored in a rotating drum at temperatures of 6 degrees c or 32 degrees c and relative humidities of 30% or 90%. the aerosols were sampled at seven minutes, one, two and three hours after the start of generation with an all glass impinger (agi-30) and titrated for infectivity in cell cultures. physical decay was determine ...1979226246
an alternative method for evaluating potency of modified live canine parainfluenza virus vaccine. 1978226552
increased resistance to influenza as a possible source of heterozygote advantage in cystic fibrosis.cystic fibrosis is the most common lethal or semi-lethal genetic disease in caucasians of central european origin, among whom it is inherited as an autosomal recessive trait at a frequency approximately 10 times that expected from recurrent mutation alone. a decreased sialic acid content has been observed in cell surface glycoproteins on cystic fibrosis fibroblasts and in numerous soluble glycoprotein preparations from cystic fibrosis homozygotes. sialic acid residues on cell surface glycoconjug ...1979226848
etiologic differentiation in lower respiratory tract virus infections by indirect immunofluorescence. 1979227647
involvement of microtubules and 10-nm filaments in the movement and positioning of nuclei in syncytia.previous studies (holmes, k.v., and p.w. choppin. j. exp. med. 124:501-520; j. cell biol. 39:526-543) showed that infection of baby hamster kidney (bhk21-f) cells with the parainfluenza virus sv5 causes extensive cell fusion, that nuclei migrate in the syncytial cytoplasm and align in tightly-packed rows, and that microtubules are involved in nuclear movement and alignment. the role of microtubules, 10-nm filaments, and actin-containing microfilaments in this process has been investigated by imm ...1979227913
comparison of different tissue cultures for isolation and quantitation of influenza and parainfluenza viruses.rhesus and cynomolgus monkey kidney tissue cultures and two continuous lines, madin-darby canine kidney (mdck) and llc-mk2, were compared in titrations and isolations of influenza and parainfluenza viruses. tube cultures were inoculated with laboratory virus strains or stored patient specimens and observed for hemadsorption. trypsin was added to the medium of the continuous lines to increase sensitivity. all four tissue cultures gave similar titers of influenza a/ussr (h1n1), a/texas (h3n2), and ...1979227920
characterization of bovine parainfluenza virus type 3.bovine parainfluenza virus type 3 (piv-3) has a buoyant density of 1.197. the rna of piv-3, like that of sendai virus, is a single continuous chain which lacks polyadenylic acid sequences and tends to self-anneal to a marked extent. it has a sedimentation coefficient of 42s and a molecular weight of 4.5 x 10(6), being slightly smaller than sendai virus rna (47s, 5.3 x 10(6)). piv-3 has 5 main structural proteins, of which 2 are glycoproteins. the molecular weights of protein 1, protein 2, protei ...1979228163
early interactions of viruses with cellular membranes. 1979228540
[a serological study of respiratory infections in pilgrims to mecca]. 1978229604
anterior segment and external ocular manifestations of infectious diseases in children.anterior segment and external ocular manifestations of some infectious diseases which are particularly important to patients of the pediatric age group are discussed. a brief review of the various systemic diseases is given along with the ocular findings. approaches to diagnosis, therapy, and management of both the systemic and ocular components of the illnesses are included.1979230214
establishment of persistent infection by parainfluenza virus type 3: role of a syncytium inhibitor.a strain of parainfluenza virus type 3 (para 3) that had undergone a series of undiluted passages failed to produce syncytia when inoculated on to vero cells at a high m.o.i. the strain repeatedly produced stable persistent infections. persistently infected cells were resistant to superinfection by homologous virus, showed the presence of virus-specific antigen and shed low quantities of infectious virus into the supernatant fluid. the undiluted passage parainfluenza virus type 3 strain produced ...1979230293
[viral infection and sudden perceptive deafness (serological examinations) (author's transl)].among the numerous and various known etiologies of sudden deafness viral infection is discussed. therefore sera of 126 patients were examined for viral antibodies to influenza, parainfluenza, mumps, measles, rs-virus, rubella, herpesvirus and adenovirus. they were compared to sera of healthy patients. our results suggest no strong association between sudden deafness and viral infection.1979231159
the experimental production of pneumonia in calves by intranasal inoculation of parainfluenza type iii virus.thirteen colostrum deprived calves were inoculated with a low passage field strain of parainfluenza type iii (pi 3) virus. virus was administered by the intranasal route and the calves were experimentally infected twice daily for four consecutive days. clinical signs of respiratory disease were noted and pneumonia was present in 12 animals at necropsy. pi 3 virus was isolated from the lung lesions and no other respiratory pathogens could be demonstrated. the pneumonic lesions grossly, histologic ...1979231340
[trial of a hyperimmune serum against para-influenza 3, bovine adenovirus 1, infectious rhinotracheitis and mucosal disease].a four-valent serum was obtained by parallel hyperimmunization of cattle with live viral suspensions of parainfluenza-3, bovine adenovirus i, the virus of infectious rhinotracheitis and the mucous disease virus. the serum's neutralizing titres are between 1:1280 and 1:2560. the lasting exploitation of serum producing cattle indicates that no competition exists between the four antigens used in the process of hyperimmunization. experimental testing of the serum on calves and its application in pr ...1979231341
[the preventive effect of interferon on upper respiratory disease. 1. the influence of interferon on the serum hi antibody titers against influenza and parainfluenza viruses (author's transl)]. 1979231626
[inhibition of vaccinia, sindbis and para-influenza virus replication by isatin beta-thiosemicarbazone derivative and methisazone in vitro and in vivo]. 1979232050
experimental infection of laboratory animals with parainfluenza-3 virus. 1979232483
infection of cultured human type ii pneumonocytes with certain respiratory viruses.human type ii alveolar pneumonocytes were grown either as monolayers derived from a clone or as organotypic cultures of fetal lung. the type ii cells in these cultures retained in their cytoplasm multilamellar bodies which were morphologically identical to similar organelles present in type ii cells of intact human fetal and adult lung. a number of respiratory viruses infected the cells and produced a cytopathic effect in the cultures. viral components were also detected in some of the infected ...1979232693
viral intestinal infections of animals and man. 1979232863
[seroepidemiologic study of viruses in morocco. iii. distribution of parainfluenza antibodies types 1, 2, and 3 among different age groups of the moroccan population 1976-1977]. 1979233025
infections in the wheezy child. 1979233244
[research on substances with antiviral activity. x. 1-substituted-2-(methylamino) naphtho/2,1-b/furan hydrochlorides].some 2-(methylamino)naphtho [2,1-b] furans hydrochlorides 1-substituted were synthetized and investigates for antiviral activity in vitro against herpes simplex virus type i (vhs-i) and parainfluenza virus type 3 ha-i/cr-8 stock.1979233363
[serological survey for virus and mycoplasma infections (author's transl)].the authors describe the two years follow up of complement fixing antibodies vs 4 viral antigens (herpes simplex, herpes zoster, cytomegalovirus, respiratory syncytial virus, mycoplasma pneumoniae). they evaluate the seasonal trend and the eventual clinical correlations on 3267 sera and 254 spinal fluids from hospitalized patients.1979233415
[diagnosis of para-influenza infection and the state of humoral immunity to para-influenza virus in children]. 1975237385
adenosine triphosphate phosphoydrolase activity associated with purified parainfluenza type 3 virions.an adenosine triphosphate phosphohydrolase associated with purified parainfluenza type 3 virions has been characterized. it hydrolyzed atp to adp and amp when activated with mg-2+ ions. using ca-2+ the production of adp was inhibited but not that of amp. neither k+ nor na+ ions were required for the expression of maximal activity. ouabain had no inhibitory effect on enzyme activity even at 10-3m. after exposure of virus preparations to tween 20, enzyme activity was not affected. a linear relatio ...1975239572
[virus infections of the respiratory tract in childhood (author's transl)].comprehensive epidemiological studies revealed that every individual is suffering from a respiratory tract infection in the average 6 times a year. 97% of these are caused by viruses. identical clinical symptoms may be produced by many different agents, thus the etiology of an illness can only be identified by virus isolation and serological tests. the frequency of isolations is varying in adults and in children as well as in ambulatory and in hospitalized patients. the persistently observed sus ...1975241719
respiratory syncytial virus in naples outbreak. 1979255512
respiratory syncytial virus theory on naples' deaths. 1979257184
resistance of chickens to challenge with the virulent herts 33 strain of newcastle disease virus induced by prior infection with serologically distinct avian paramyxoviruses.results indicate that some degree of protection from challenge by newcastle disease virus (ndv)/herts 33 was conferred on chickens by prior infection with pmv/turkey/wisconsin/68, pmv/turkey/ontario/6661/68, pmv/netherlands/449/75 and pmv/parakeet/england/39/78 viruses, all of which are serologically related but distinguishable from ndv. except for one bird which survived challenge three weeks after infection with robin/hiddensee/19/75, no protection was seen in chickens infected with other unre ...1979262602
neonatal respiratory-syncytial-virus infection. 1979313006
measles virus meningoencephalitis. immunofluorescence study of brains infected with virus mutants.the localization of measles virus antigens in hamster brains inoculated with a temperature-sensitive mutant of measles virus r its revertant was studied by immunofluorescence. we found significantly less virus antigen in mutant-inoculated than in revertant-inoculated brains. in mutant-inoculated brains the virus antigens were very often found in the meninges. possible mechanisms for the development of experimental hydrocephalus and meningoencephalitis are discussed.1977320383
bronchiolitis: differentiation from infantile asthma. 1977329197
[the pathogenesis of multiple cerebrospinal sclerosis. present state of knowledge and concepts (author's transl)]. 1978350405
[theories concerning the etiology of multiple sclerosis]. 1977355032
the immunologic response to infection with respiratory syncytial virus in infants.fifty infants younger than six months, hospitalized for infection with respiratory syncytial virus (rsv), were studied by examination of serial samples of nasal secretion. secretory neutralizing activity was measured by plaque reduction and secretory antibody by indirect fluorescence using conjugated antiserum to human iga, igg, or igm. secretory neutralizing activity during infection rose or fell fourfold with approximately equal frequency (20% and 26%, respectively). in contrast, levels of iga ...1978355574
respiratory syncytial virus infection: admissions to hospital in industrial, urban, and rural areas. report to the medical research council subcommittee on respiratory syncytial virus vaccines.a collaborative study of 10 centres during the winters of 1973-4 and 1974-5 showed that respiratory syncytial virus (rsv) was the major cause of admission to hospital for respiratory disease in children under 5 years of age in industrial, urban, and rural communities. in all areas the distribution of clinical symptoms and their severity was similar, but the rate of admission in relation to population was over twice as high in industrial as in other areas. the maximum yearly admission rate occurr ...1978359099
respiratory syncytial virus infection. rapid diagnosis in children by use of indirect immunofluorescence.specimens of 387 nasopharyngeal suction smears obtained from 354 children hospitalized with acute respiratory infections during an eight-month period were examined for the presence of respiratory syncytial (rs) virus by the indirect immunofluorescence antibody technique (ifat) and by conventional tissue culture infectivity techniques. respiratory syncytial virus was identified in nasopharyngeal suction smear specimens from 123 of these specimens (32%) with the use of both techniques. of the spec ...1978362894
the pathogenesis of respiratory syncytial virus infection in cotton rats.the cotton rat is susceptible to respiratory synctial virus infection in both the upper and lower portions of the respiratory tract. virus replicates to high titer in the nose and lungs and to relatively low titer in the trachea. immunofluorescence studies demonstrated viral antigen in the nasal epithelium and the bronchial and bronchiolar epithelium but not in the trachea or the alveolar cells of the lungs. histopathologic changes included a desquamative, exudative rhinitis of moderate severity ...1978362946
nosocomial respiratory syncytial virus infections in an intensive care nursery: rapid diagnosis by direct immunofluorescence.a nosocomial outbreak of respiratory syncytial virus infections involved 8 of 17 infants in an intensive care nursery and one additional infant in the adjoining newborn nursery. immunofluorescent staining of nasopharyngeal specimens was positive in six of seven virologically confirmed cases (86%). one additional case with negative viral cultures was also identified by this technique. viral isolation in tissue cultures required an average of 4.9 days, whereas results of immunofluorescent studies ...1979382079
respiratory syncytial virus infection in adults: clinical, virologic, and serial pulmonary function studies.we prospectively studied 10 previously healthy adults who developed an acute respiratory illness while working in an infants' ward during a community outbreak of respiratory syncytial virus infection. in addition to clinical and viral evaluation, total respiratory resistance before and after carbachol aerosol inhalation was measured. all 10 subjects had respiratory syncytial virus infection documented by viral isolation, and all developed pronounced cough, nasal congestion, and fever. eight subj ...1978415653
a paramyxovirus causing fatal gastroenterocolitis in marmoset monkeys.a paramyxovirus has been isolated, identified and characterized. the virus causes a disease characterized clinically by severe diarrhea, dehydration and death. microscopically the disease is characterized as a proliferative gastroenterocolitis with focal necrosis of the mucosa, by giant syncytial cells and eosinophilic intranuclear and intracytoplasmic inclusions. the virus is closely related to measles virus antigenically.1978417328
reye's syndrome associated with respiratory syncytial virus infection.an upper respiratory tract infection in a 22-month-old boy was followed by rapid loss of consciousness, hypoglycaemia, uraemia, and death. necropsy examination showed fatty change of liver and kidneys, severe cerebral oedema, bronchiolitis, and endocardial fibroelastosis affecting the left ventricle. immunofluorescence staining showed infection with respiratory syncytial virus (rsv). the clinical and pathological findings were those of reye's syndrome, not previously reported accompanying rsv in ...1979420528
cell-free and cell-bound antibody in nasal secretions from infants with respiratory syncytial virus infection.twenty-two infants under 9 months of age hospitalized with bronchiolitis or pneumonia due to respiratory syncytial virus (rsv) were serially sampled to determine the pattern of secretory antibody response. using double labeling techniques, we found several types of immunoglobulin in secretions: cell-free antibody to rsv of the immunoglobulin a (iga), immunoglobulin g (igg), and immunoglobulin m (igm) classes; and immunoglobulins of all three classes bound to rsv-infected cells shed from the nasa ...1979422241
cell-mediated immune response to respiratory syncytial virus infection: relationship to the development of reactive airway disease.the possibility that cell-mediated immunity might play a role in the pathogenesis of infection with respiratory syncytial virus was evaluated in a study of 39 infants. infection with rsv was confirmed by identification of virus in nasopharyngeal secretions using immunofluorescence, and by tissue culture infectivity. cmi, as determined by a whole blood lymphocyte transformation technique, was evaluated in samples taken 0 to 10 and 20 to 60 days after the onset of illness. patients diagnosed as ha ...1979423016
respiratory syncytial virus and sudden infant death. 1979440395
respitory syncytial virus and sudden infant death. 1979440396
respiratory syncytial virus and sudden infant death. 1979440397
immunoprophylaxis of respiratory syncytial virus infection in the infant ferret.infant ferrets can be protected from respiratory syncytical virus challenge at 3 days of age by gestational infection of their mothers. ferrets acquire their immunity to respiratory syncytial virus postpartum via immunizing products of lactation. the level of protection against viral replication correlates with the maternal serum neutralizing titer or a concomitant factor. passive administration of adult ferret serum with a neutralizing titer of 1:1024 or greater, either i.p. or orally does not ...1979448139
clinical and physiological manifestations of bronchiolitis and pneumonia. outcome of respiratory syncytial virus.the physiological abnormalities and clinical correlates of 32 infants consecutively hospitalized with lower respiratory tract disease from respiratory syncytial virus (rsv) were studied in an attempt to characterized the infant most at risk for the acute and long-term complications of rsv infection. arterial oxygen saturation (sao2) determinations were obtained daily by means of an ear oximeter. on admission all infants were hypoxemic with a mean sao2 of 87% (range, 74% to 95%). the mean of the ...1979463835
lymphocyte transformation in response to antigens of respiratory syncytial virus. 1979482291
respiratory syncytial virus: a community problem. 1979486998
[results obtained using an attenuated bovine syncytial virus vaccine against bronchopneumonia of yearlings (author's transl)].bronchopneumonia of yearlings is a respiratory infection with bovine respiratory syncytial virus (brs virus) occurring as a herd disease in young cattle. in severe cases, the clinical picture is identifiable; characteristic features are laboured respiration and a high morbidity rate. following an acute onset, atypical interstitial pneumonia is observed on postmorten examination and bacteriological studies are negative. an attenuated live brs virus vaccine was used against bronchopneumonia of yea ...1979494211
[viral vaccines and local immunity]. 1979502677
solid-phase radioimmunoassay of serum immunoglobulin a antibodies to respiratory syncytial virus and adenovirus.a solid-phase radioimmunoassay for detecting respiratory syncytial virus and adenovirus serum immunoglobulin a (iga) antibodies was developed. an antigen consisting of purified adenovirus type 2 hexons or a crude lysate of respiratory syncytial virus-infected cells was first adsorbed onto polystyrene beads. the coated beads were then incubated with dilutions of serum, and iga antibodies which attached to the solid-phase virus antigen were subsequently detected with 125i-labeled anti-human alpha ...1979511988
[the significance of respiratory syncytial virus as pathogen in respiratory tract infections in infants (author's transl)].ten out of twenty babies aged up to twelve months and admitted during the months february and march 1978 were shown to be infected with respiratory syncytial virus. during the first 6 months of life the disease usually presents as bronchiolitis. serologically only neutralising antibodies were demonstrable in this age group. iga was usually raised in babies with bronchopneumonia. an allergic reaction between virus antigen and maternal antibodies is considered to occur, assuming an activation of t ...1979516739
a respiratory syncytial virus outbreak in a transitional care nursery. 1979517481
non-productive paramyxovirus infection: nariva virus infection in hamsters.the pathogenesis of infection with nariva virus (nv)--recently classified as a paramyxovirus--was studied in the hamster, an animal closely related to the natural host. intracranial inoculation of suckling hamsters produces an acute necrotizing encephalitis with large amounts of infectious virus and virus antigen in the brain. in contrast, weanling hamsters have only small amounts of infectious virus and only early in the disease, when they are well; later, when clinically ill, they have a non-p ...1979518307
giving rsv vaccine intranasally. 1979519462
respiratory syncytial virus with apnoea treated with theophylline. 1979522760
a hitherto unreported paramyxovirus of turkeys.a newly isolated avian virus is described which was obtained from a flock of laying turkey hens with respiratory disease and accompanying egg production drop. characterisation of the virus indicated it to be of the paramyxovirus group and to be related through antigenic crossing with newcastle disease virus. examination of turkey sera from five separate flocks indicated natural infection with the paramyxovirus to be relatively widespread. experimental infection of turkeys produced only mild resp ...1979523797
lesions in lambs experimentally infected with bovine respiratory syncytial virus.respiratory syncytial virus was inoculated intratracheally into five 1-week-old lambs. three of the lambs responded clinically with fever, hyperpnea, and listlessness. pulmonary lesions consisted of multifocal areas of consolidation, with necrosis of individual epithelial cells of the airways and accumulation of necrotic debris, macrophages, and few neutrophils in terminal airways and alveoli. pulmonary septa in affected areas were infiltrated with numerous macrophages and lymphocytes. viral par ...1979525867
experimental respiratory syncytial virus infection in feeder-age lambs.signs of disease, lesions, and serologic response were seen in six 6-month-old-lambs experimentally inoculated with respiratory syncytial virus (rsv). a transient febrile response, mild hyperpnea, and listlessness were seen. multifocal areas of interstitial pneumonia and bronchiolitis were seen in lambs necropsied during the period of clinical response. a serologic response to rsv was seen in all lambs, and rsv was recovered from five lambs.1979525890
respiratory syncytial virus, 1979: scotland. 1979526842
clinical and radiological studies in children with respiratory syncytial virus infection. 1979546771
respiratory syncytial virus infection in inbred mice.respiratory syncytial virus infected the nose and lungs of each of 20 strains of inbred mice, with viral titers varying 100-fold from least permissive to most permissive strains. viral titers appeared to be under genetic control, but did not correlate with the h-2 haplotype.1979546793
incidence of rs virus infections in premature children's ward.in the course of two years (1974-76) four outbreaks of acute respiratory disease in the premature children's ward of a prague hospital were studied virologically and clinically. rs virus (rsv) was found to be the aetiological agent. the highest isolation rate of rsv was achieved when using two heteroploid cell lines (l-132 and hep-2 cells) simultaneously. of the 30 children examined, 60% showed a severe course of disease (pneumonia and/or bronchiolitis) while in 40% of the children the disease h ...1979575897
[clinical characteristics of respiratory-syncytial infection in adults]. 1977604645
study of 8-year-old children with a history of respiratory syncytial virus bronchiolitis in infancy.thirty-five children known to have had respiratory syncytial virus bronchiolitis in infancy were examined at the age of 8 and their respiratory function tested. the results were compared with those in 35 controls matched for age, sex, and social class. although 18 of the children who had had bronchiolitis in infancy had experienced subsequent episodes of wheezing, these were neither severe nor frequent in most cases and had apparently ceased by the age of 8. nevertheless, the mean exercise bronc ...1978620129
[biological and physico-chemical characterization of an aviary hemagglutinating agent]. 1978645123
interferon in nasal secretions from infants with viral respiratory tract infections.interferon levels in nasal secretions of infants under one year of age, and hospitalized with lower repiratory tract disease, were measured during two respiratory infection seasons. in the first year serial secretions from 50 infants with respiratory syncytial virus infection were examined. undetectable or low levels of interferon were found in all samples, and mean levels did not fluctuate significantly in relation to disease and recovery. this was in contrast to anti-rsv iga, which appeared an ...1978650342
juvenile onset diabetes mellitus in pregnant women: failure to associate with coxsackie b1-6, mumps, or respiratory syncytial virus infections. 1978660368
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