| antichlamydial antimicrobial therapy for asthma. | | 1995 | 7726929 |
| susceptibility of chlamydia pneumoniae to oral agents commonly used in the treatment of respiratory infection. | | 1994 | 7730224 |
| chlamydia pneumoniae. | chlamydia pneumoniae, a fairly recent addition to the genus chlamydia, has been shown to cause community-acquired and nosocomial pneumonias, and to be a common infectious agent in human populations throughout the world. it has a wide variety of clinical presentations, and may be associated with ischaemic heart disease. like other species in the genus, it is difficult to isolate by cell culture: clinical diagnosis therefore rests on other techniques, each of which presents particular problems. th ... | 1994 | 7730230 |
| antibiotics in acute bronchitis. | | 1995 | 7739333 |
| diagnosis of infection caused by chlamydia pneumoniae (strain twar) in patients with "ornithosis" in southern sweden 1981-1987. | serological distinction between ornithosis and infection by chlamydia pneumoniae (strain twar) was attempted by microimmunofluorescence (mif) of 156 cases previously considered as ornithosis on the ground of a positive complement fixation test with a chlamydia group antigen. at least 23% of these cases were twar infections according to the results at retesting by mif. the highest frequency of twar infections was demonstrated during 1981 with a decreasing number and proportion thereafter. we cont ... | 1989 | 2694349 |
| erythema nodosum--a manifestation of chlamydia pneumoniae (strain twar) infection. | we describe 2 cases of erythema nodosum (en) secondary to an infection with the twar strain of chlamydia, recently designated chlamydia pneumoniae. two young patients, 17 and 11 years old, were admitted with en and no physical signs of pneumonia. one patient had a non-productive cough and fever. the other patient only ran a high fever. chest radiography revealed bronchopneumonias. infection with the c. pneumoniae species was proven by serologic testing using microimmunofluorescence technique. se ... | 1989 | 2694350 |
| experimental infection of baboons (papio cynocephalus anubis) with chlamydia pneumoniae strain 'twar'. | two infant baboons (papio cynocephalus anubis) were inoculated with chlamydia pneumoniae strain 'twar', one in the conjunctiva, nasopharynx and oropharynx, the other in the trachea. both remained well during 8 weeks of observation. c. pneumoniae infection persisted for at least 8 weeks after inoculation. chlamydia pneumoniae seems to be of low virulence in baboons and capable of causing chronic infection. | 1989 | 2778341 |
| chlamydia pneumoniae (twar): a common agent in acute bronchitis. | | 1994 | 7747109 |
| experimental chlamydia pneumoniae infection in mice: effect of reinfection and passive immunization. | nih/s mice were infected intranasally with chlamydia pneumoniae isolate kajaani 6 and rechallenged after either 28 or 70 days. a partial resistance to reinfection, indicated by a reduced recovery of live organisms, was noted at both time points of rechallenge: positive isolations from lung homogenates and/or bronchoalveolar lavage fluids were observed in fewer mice and the yields of isolated chlamydiae remained smaller, as compared to primary infection. however, a previous infection did not conf ... | 1995 | 7476093 |
| chlamydia pneumoniae pneumonia with endocarditis. | | 1995 | 7752791 |
| polymerase chain reaction for detection of chlamydia pneumoniae in gargled-water specimens of children. | the objective of the present study was to establish the occurrence of chlamydia pneumoniae by direct detection in gargled-water specimens obtained from 193 children suffering from acute or chronic respiratory infections. specimens were analyzed by an indirect immunofluorescence test (iif), a genus-specific antigen enzyme immunosorbent assay (eia) and the polymerase chain reaction (pcr). the pathogen was detected in three children by pcr only. as underlying disease, chronic obstructive bronchitis ... | 1995 | 7758482 |
| in vitro susceptibility of human vascular wall cells to infection with chlamydia pneumoniae. | chlamydia pneumoniae is a common respiratory pathogen. recent studies have demonstrated the presence of c. pneumoniae in coronary and aortic atherosclerotic lesions. to study the role of c. pneumoniae in atherosclerosis, we investigated the susceptibilities of three different cells of the human vascular wall to infection with c. pneumoniae ar-39. these cell types were endothelial cells, smooth muscle cells, and macrophages derived from peripheral blood monocytes. infection was assessed by using ... | 1995 | 7494038 |
| reactive arthritis ascribed to chlamydia pneumoniae. report of a case. | | 1995 | 7788343 |
| further characterization of chlamydia pneumoniae specific monoclonal antibodies. | studies using monoclonal antibodies have demonstrated species-specific reactivities with chlamydia pneumoniae. in this study, further characterization of c. pneumoniae specific monoclonal antibodies tt-205 and rr-402 and description of c. pneumoniae specific antibodies prepared against other isolates are presented. tt-205 and rr-402 were shown to neutralize infectivity. neutralization in cell culture was specific and enhanced by complement. attempts to characterize the reactive antigen by immuno ... | 1995 | 7494492 |
| inhibition of chlamydia pneumoniae growth in hep-2 cells pretreated with gamma interferon and tumor necrosis factor alpha. | an in vitro culture system was used to study the effects of increasing concentrations of human cytokines on the intracellular replication of chlamydia pneumoniae. hep-2 cell monolayers, pretreated for 24 h with 200 u of human recombinant gamma interferon (ifn-gamma) per ml restricted the intracellular replication of c. pneumoniae. tumor necrosis factor alpha (tnf-alpha; 25 ng/ml) exhibited a synergistic effect with ifn-gamma by reducing the concentration of ifn-gamma necessary to restrict intrac ... | 1995 | 7790105 |
| detection of anti-chlamydia pneumoniae ige in children with reactive airway disease. | an association of chlamydia pneumoniae infection and reactive airway disease has been demonstrated in children. to determine if c. pneumoniae infection triggers production of c. pneumoniae-specific ige, sera were examined from 45 children with and without c. pneumoniae infection. anti-c. pneumoniae ige was demonstrated by immunoblotting in 12 (85.7%) of 14 culture-positive asthmatic patients with wheezing compared with only 1 (9.1%) of 11 culture-positive patients with pneumonia, 2 (18.2%) of 11 ... | 1995 | 7797928 |
| [pneumonia in clinical practice: diagnosis and therapy]. | outpatients with pneumonia are usually treated empirically. therefore, the knowledge of the most important causative agents is a prerequisite for the 'educated guess'. with a broad microbiological evaluation, the etiology of a pneumonia can be detected in only half of the cases. in outpatients, 30% of the causative agents are viruses, 45% 'atypical bacteria' such as mycoplasma sp. and chlamydia pneumoniae, and 25% pneumococci and hemophilus. in hospitalized patients, pneumococci and hemophilus c ... | 1994 | 7801011 |
| [detection of chlamydia pneumoniae in intrathoracic abscesses--a case report]. | the case of a 52-year-old patient with intrathoracic abscesses following a traumatic fracture of the 11th thoracic vertebral body is described. the abscesses were resistant to conventional antibiotic therapy and attempts at local drainage under ct scan control remained unsuccessful. finally, chlamydia pneumoniae was isolated using an immunofluorescence technique. subsequent therapy with doxycycline caused complete resolution of the abscesses. we suggest that in cases of atypical pneumonias and a ... | 1994 | 7802891 |
| acute respiratory tract infection in daycare centers for older persons. | to evaluate the rate of specific pathogens and clinical syndromes associated with acute respiratory tract infections (arti) in frail older persons attending daycare. | 1995 | 7806736 |
| antimicrobial susceptibility and therapy of infections caused by chlamydia pneumoniae. | | 1994 | 7810992 |
| comparison of sample preparation methods for detection of chlamydia pneumoniae in bronchoalveolar lavage fluid by pcr. | amplification inhibitors can lead to false-negative results for pcr. in order to evaluate the reliability of pcr for the detection of chlamydia pneumoniae, the presence of pcr inhibitors in 75 bronchoalveolar lavage specimens was assessed after treatment by various sample preparation methods. specimens were collected from patients with acute respiratory infections, including four cases of proven c. pneumoniae infection. substances inhibitory to the amplification of chlamydial dna continued to be ... | 1994 | 7814512 |
| [clinical and serological studies in six cases of chlamydial pneumonia]. | clinical and serological studies of chlamydial pneumonia were done in six patients (three men and three women). the other three patients had no avian contact and showed almost the same clinical symptom. acute infection with chlamydia psittaci and chlamydia pneumoniae were diagnosed in two patients and in one patient, respectively, by mfa. because in some cases chlamydia psittaci pneumonia and chlamydia pneumoniae pneumonia are difficult to differentiate, it is necessary to use a test that allows ... | 1994 | 7815757 |
| community-acquired pneumonia in adults. | although the frequency of community-acquired pneumonia caused by streptococcus pneumoniae continues to be high, studies show that mycoplasma pneumoniae, chlamydia pneumoniae, or legionella pneumophila are the etiologic agents in 20% to 40% of community-acquired pneumonia in adults. the clinical presentation of pneumonia caused by these organisms may be indistinguishable from pneumonia due to s pneumoniae. separation of cases of pneumonia due to s pneumoniae as typical and that caused by m pneumo ... | 1994 | 7817549 |
| mycoplasma contamination of chlamydiae isolated from clinical specimens. | ten chlamydia pneumoniae strains were screened for mycoplasma contamination using two differently designed mycoplasma-specific polymerase chain reactions (pcr). the primers of the mycoplasma-specific pcr designed by spaepen et al. (9) cross-reacted with all of the c. pneumoniae strains giving false-positive results. when the 10 strains of c. pneumoniae were tested for mycoplasmas with the pcr designed by harasawa et al. (5), only 3 were positive. mycoplasmas were cultured from these three c. pne ... | 1994 | 7826610 |
| community-acquired pneumonia: the future of the microbiology laboratory: focused diagnosis or syndromic management? | the traditional classification of community-acquired pneumonia into typical and atypical pneumonia to facilitate successful empirical treatment is no longer optimal. an accurate prediction of cause and adequate empirical therapy cannot be provided with this approach in severely ill patients. there is an increasing spectrum of recognized treatable pathogens presenting as community-acquired pneumonia including legionella species, chlamydia pneumoniae, and pneumocystis carinii in addition to the tr ... | 1994 | 7831539 |
| [advance in the study of chlamydia pneumoniae]. | | 1994 | 7834699 |
| infectious diseases. | | 1995 | 7838014 |
| 'atypical' bacteria are a common cause of community-acquired pneumonia in hospitalised adults. | to assess the proportion of cases of community-acquired pneumonia caused by 'atypical' bacteria, including the recently discovered chlamydia pneumoniae, and to compare the clinical, radiographic and laboratory features of patients with and without 'atypical' bacteria. | 1994 | 7839256 |
| isolation and characterization of a gene encoding a chlamydia pneumoniae 76-kilodalton protein containing a species-specific epitope. | chlamydia pneumoniae is a human respiratory pathogen. unlike the other two chlamydia species, no species-specific antigen has been defined for c. pneumoniae. an immunoreactive clone containing a 0.8-kb fragment was isolated from a c. pneumoniae (ar-39) genomic library by using anti-c. pneumoniae rabbit immune serum. by southern hybridization analysis of chromosomal digests of the different chlamydia spp., the 0.8-kb fragment was shown to react specifically with c. pneumoniae. subcloning of this ... | 1994 | 7509320 |
| prevalence of specific antibodies to chlamydia pneumoniae in children with acute respiratory infections. | we investigated 56 boys and 30 girls between the ages of 1 month and 15 years with acute respiratory infections for antibodies to chlamydia pneumoniae and mycoplasma pneumoniae. antibodies were only occasionally found in children less than 10 years of age (4% of boys (1/23) and 5% of girls (1/19). in the age group 10-12 years, antibodies were detected in 55% of boys (4/9) but not in the 2 girls investigated. in the age group 13-15 years, antibodies were detected in 58% of boys (14/24) and in 33% ... | 1994 | 7841726 |
| comparison of chlamydia pneumoniae isolates by western blot (immunoblot) analysis and dna sequencing of the omp 2 gene. | the 60-kda cysteine-rich outer membrane protein gene (omp 2) from nine chlamydia pneumoniae isolates (tw-183, cm-1, cwl-050, cwl-011, iol-207, fil, kajaani-6, helsinki-12, and parjaanonen) was amplified by pcr and sequenced from positions 1 to 580. in contrast to the sequence differences previously observed in this gene in other chlamydial species, all nine c. pneumoniae isolates were 100% identical. however, when sera from c. pneumoniae microimmunofluorescence-positive patients (with clinical s ... | 1994 | 7852577 |
| [chlamydia infections and possibilities for prevention]. | | 1993 | 7513175 |
| chlamydial infection and reactive airway disease. | | 1995 | 7858699 |
| incidence of lower respiratory tract infections caused by mycoplasma, chlamydia and legionella: an italian multicenter survey. | a collaborative retrospective study based on serologic diagnosis was conducted to assess the etiological role sustained by privileged pathogens in italy. the results obtained indicate the mycoplasma, chlamydia and legionella are important etiologic agents of lower respiratory tract infections in italy since they account for about 31% of the cases taken into consideration in this survey. we found a high incidence of m. pneumoniae (12.3%), c. pneumoniae (10.5%) and l. pneumophila (8.3%). these res ... | 1994 | 7861196 |
| group a streptococcal tonsillopharyngitis: cost-effective diagnosis and treatment. | most patients who seek medical attention for sore throat are concerned about streptococcal tonsillopharyngitis, but fewer than 10% of adults and 30% of children actually have a streptococcal infection. group a beta-hemolytic streptococci (gas) are most often responsible for bacterial tonsillopharyngitis, although neisseria gonorrhea, arcanobacterium haemolyticum (formerly corynebacterium haemolyticum), chlamydia pneumoniae (twar agent), and mycoplasma pneumoniae have also been suggested as possi ... | 1995 | 7864482 |
| azithromycin in the treatment of pneumonia caused by chlamydia pneumoniae: report of a case. | we report a 67-year-old male with pneumonia in which chlamydia pneumoniae was identified by serologic studies as the causative agent. after initial treatment failure with amoxicillin + clavulanic acid, pneumonia was successfully treated with the administration of oral azithromycin, 500 mg per day, for three days. azithromycin is a new macrolide which has a long half-life and superior action to erythromycin. it provides a new and alternative choice in the treatment of chlamydia pneumoniae infecti ... | 1994 | 7866068 |
| systemic dissemination of chlamydia pneumoniae following intranasal inoculation in mice. | although chlamydia pneumoniae is a respiratory pathogen, there is increasing evidence of involvement of the organisms in anatomic sites other than the respiratory tract. a mouse model was used to study dissemination of organisms following intranasal, intravenous, and subcutaneous inoculation with c. pneumoniae. after inoculation by any of the three routes, the organism was isolated consistently from lungs and spleen. it was also detected in peritoneal macrophages after intranasal and intravenous ... | 1995 | 7876631 |
| [a child with iritis due to chlamydia pneumoniae infection]. | a case of uncommon iritis due to chlamydia pneumoniae (c. pneumoniae) is reported. the patient was a 9-year-old boy who had suffered from cough, pharyngeal pain, and low grade fever. the symptoms persisted for more than 1 month in spite of an oral cephem antibiotic. ophthalmalgia, congestion around the iris and cough had lasted with alleviation and exacerbation. a diagnosis of c. pneumoniae infection was made by specific polymerase chain reaction (pcr) method and microimmunofluorescence test (mi ... | 1994 | 7876679 |
| lessons for atherosclerosis research from tuberculosis and peptic ulcer. | knowledge of the causes of a disease is essential to the effective alteration of factors affecting the disease's incidence. the history of the medical understanding of tuberculosis and peptic ulcer shows that we may neglect to consider the contribution of microorganisms to long-term or recurring diseases. the author presents evidence that we may similarly be overlooking the role of microorganisms in atherosclerosis. a collaborative, comprehensive investigation of the role of microorganisms in at ... | 1995 | 7882229 |
| incidence of community-acquired pneumonia and chlamydia pneumoniae infection: a prospective multicentre study. | this one year prospective multicentre study was designed to determine the incidence of community-acquired pneumonia in adults. it was carried out in primary health care centres and three reference hospitals, located in the 'maresme' region (barcelona, spain) serving a population of 39,733 subjects over 13 years of age. patients suspected of having contracted community-acquired pneumonia were visited by their family doctors and referred to the three reference hospitals for confirmation of the dia ... | 1993 | 7710453 |
| respiratory infection with chlamydia pneumoniae in middle-aged and older adult outpatients. | this study was undertaken to characterize the epidemiology and clinical presentation of infection with chlamydia pneumoniae in a population composed primarily of middle-aged and older adults. pharyngeal swabs and acute and convalescent phase sera were obtained from outpatients presenting with signs and symptoms of an acute respiratory infection. sera were examined using the micro-immunofluorescence (mif) test to detect antibody to chlamydia pneumoniae and complement fixation tests to detect myco ... | 1994 | 7889946 |
| chlamydia specific igg and iga serum antibodies in a study of homosexual men at various clinical stages of hiv related disease. | the significance of chlamydia serum igg and iga antibodies was studied, by immunoperoxidase assay, in 210 homosexual men at various stages of hiv infection. cross sectional analysis of chlamydia igg antibodies at a titer of > or = 128 indicated a significantly higher prevalence rate among aids patients (27.0%) as compared to asymptomatic hiv seronegatives (6.0%) (p = 0.022). the geometric mean titer (gmt) of igg antibodies to chlamydia was also significantly higher in aids patients (106.4) as co ... | 1994 | 7893987 |
| characterization of a chlamydia pneumoniae strain isolated from a 57-year-old man. | the isolation of chlamydia pneumoniae, especially from elderly persons, is generally not easy. recently, we succeeded in isolating a chlamydial strain, which was designated kkpn-15, from a 57-year-old man suffering from acute bronchitis. it was compared with well established strains of c. pneumoniae, c. trachomatis and c. psittaci, and its biological properties, such as the morphology of elementary bodies (ebs) and inclusions, and the immunochemistry of eb proteins, were investigated. based on t ... | 1994 | 7898384 |
| chlamydia pneumoniae infection in children with lower respiratory tract infections. | the incidence of antibody and the clinical features of chlamydia pneumoniae (c.pneumoniae) infection have not been studied in children in japan. we investigated the incidence of c.pneumoniae antibody in sera from 580 healthy children (including 30 umbilical cord blood samples) during the 2-year period between june 1992 and june 1994. the antibody titer was determined by a microimmunofluorescence (mif) test by using the elementary body of c.pneumoniae tw-183 as the antigen. umbilical cord blood s ... | 1995 | 7564162 |
| molecular typing of chlamydia trachomatis by random amplification of polymorphic dna. | the random amplification of polymorphic dna (rapd) was used for epidemiological typing of chlamydia trachomatis strains. dna samples from 39 c. trachomatis, 1 c. pneumoniae and 2 c. psittaci strains were screened by the use of 4 single 10-mer primers. different and reproducible banding profiles were observed on agarose gel electrophoresis. no common profiles were recorded for strains from different chlamydia species. all c. trachomatis strains of trachoma biovar were distinguished from lymphogra ... | 1993 | 7902599 |
| fibrinogen: a link between chronic infection and coronary heart disease. | | 1994 | 7911935 |
| reversible acute renal failure associated with chlamydia pneumoniae infection. | | 1995 | 7566585 |
| detection of chlamydia pneumoniae twar in human coronary atherectomy tissues. | chlamydia pneumoniae twar has been associated with coronary heart disease by seroepidemiologic studies and direct detection of the organism in atheromatous lesions of coronary arteries and aorta. in this study, 38 fresh tissue specimens from patients with coronary artery lesions that were treated by directional coronary atherectomy were tested for c. pneumoniae. twenty-three specimens were from patients with primary lesions and 15 were from patients with restenoses. c. pneumoniae was detected by ... | 1995 | 7622912 |
| [successful culture of chlamydia pneumoniae in 2 asymptomatic patients]. | in two women, partners of 41 and 36 years old, positive cultures of chlamydia pneumoniae were repeatedly obtained from the throat. both individuals were asymptomatic during the period described. eradication was not achieved despite treatment with doxycycline. c. pneumoniae on the basis of serological data is considered a common cause of respiratory tract infections. however, this micro-organism has only been isolated in the netherlands once. carrier status has been described in the literature, a ... | 1994 | 7935937 |
| measurement of sputum antibodies in the diagnosis of acute and chronic respiratory infections associated with chlamydia pneumoniae. | the aim of this study was to develop methods for the measurement of sputum antibodies in the laboratory diagnosis of acute and chronic lower respiratory tract infections caused by chlamydia pneumoniae. paired serum specimens, sputum specimens, and pharyngeal or nasopharyngeal swabs were obtained from 97 patients; 51 of them had community-acquired pneumonia, and 46 had chronic obstructive pulmonary disease (copd). c. pneumoniae-specific serum immunoglobulin g (igg), iga, and igm antibodies were m ... | 1995 | 7583923 |
| [the past, present and future of arterial infection]. | today, the pathology of large and medium-sized arteries is in most part considered as degenerative or inflammatory. the role of infection has been preponderant (syphilis) but has become quite modest now, restricted to infectious aneurysms. according to certain observations, infections may participate in initiating arterial inflammation, whether it be specific (kawasaki's disease, takayasu's arteritis, coronary artery disease of cardiac grafts) or less so ("plain" atherosclerosis). suspected micr ... | 1994 | 7939301 |
| seroepidemiologic study of chlamydia pneumoniae and other chlamydial species in a hyperendemic area for trachoma in the sudan. | sera of inhabitants of angola village in central sudan were investigated for the prevalence of antibodies to chlamydia trachomatis, c. pneumoniae, and c. psittaci by the microimmunofluorescence (mif) test. clinical examination of 616 persons showed that the village is hyperendemic for trachoma. of the 448 children examined, 334 (75%) had signs of active trachoma. the corresponding prevalence in the 168 adults was 25%. using mif, antibodies to c. trachomatis were found in the sera of 27 (81%) chi ... | 1994 | 7943577 |
| diagnosis of chlamydia pneumoniae infection in patients with community-acquired pneumonia by polymerase chain reaction enzyme immunoassay. | we conducted a prospective study of 385 patients who had community-acquired pneumonia with use of a modified polymerase chain reaction (pcr) assay that detects amplified dna by enzyme immunoassay (eia). we used pcr-eia to improve detection of chlamydia pneumoniae infection and to differentiate c. pneumoniae infection from other chlamydial infections. cultures of throat swab specimens from four patients yielded chlamydia species (c. pneumoniae, one patient; chlamydia species, two patients; and c. ... | 1994 | 7948521 |
| [infections of the low respiratory tract in pediatrics]. | | 1994 | 7955954 |
| [isolation of chlamydia pneumoniae in atypical pneumonia]. | a 33-year-old man, who two months previously had been treated for bronchopneumonia with cefuroxime, fell ill again with cough, dyspnoea and fever up to 39.8 degrees c. auscultation and lung function tests indicated respiratory tract obstruction. the chest radiograph revealed an infiltrate of the left lower lobe and bronchoscopy showed hypertrophic bronchitis. empirical antibiotic treatment with clarithromycin (initially 500 mg twice daily, continued on half this dose) lead to rapid improvement o ... | 1994 | 7956770 |
| prevalence of antibodies to chlamydia pneumoniae in slovenia. | | 1994 | 7957282 |
| [studies on chlamydia pneumoniae, strain twar, infection. i. experimental infection of c. pneumoniae in mice and serum antibodies against twar by mfa]. | six to seven-week-old icr mice were inoculated intranasally with c. pneumoniae tw-183 strain and observed for sickness and death. the inoculated mice showed weakness within the 1st day and decrease in weight were observed, however, mice were cured within 7 days after inoculation. no death was observed. histopathological studies of the mice lungs clearly revealed interstitial pneumonitis on the 3rd day and parenchymal pneumoniae on the 5th day after inoculation. pathological changes were, however ... | 1990 | 2186158 |
| chlamydia pneumoniae and acute arterial thrombotic disease. | | 1995 | 7586293 |
| respiratory chlamydia: the management of an outbreak. | this investigation was undertaken in response to the occurrence of nine cases of respiratory chlamydial infection in 8 months within the district of dudley. all nine cases of respiratory chlamydia were due to chlamydia psittaci, not chlamydia pneumoniae. five cases had avian exposure, but no other aetiological factors were identified. faecal specimens were obtained from only two of the implicated birds and were negative. two local aviaries were identified as sources of implicated birds. the two ... | 1995 | 7597134 |
| chlamydia pneumoniae (twar) infections in children. | | 1994 | 7970966 |
| susceptibilities to clarithromycin and erythromycin of isolates of chlamydia pneumoniae from children with pneumonia. | we tested in vitro 49 isolates of chlamydia pneumoniae obtained from 35 children with community-acquired pneumonia against clarithromycin and erythromycin. the children were part of a treatment study comparing the two drugs. clarithromycin was 2- to 10-fold more active than erythromycin, with a mic for 90% of strains tested and minimal chlamydiacidal concentration for 90% of strains tested of 0.031 microgram/ml compared with 0.125 microgram/ml for erythromycin. eight of these children, two of wh ... | 1994 | 7979292 |
| chlamydia pneumoniae and chronic pharyngitis. | chlamydia pneumoniae has been implicated as an etiological agent for both upper and lower respiratory tract infections. we describe 4 cases of chronic pharyngitis where chlamydia pneumoniae appears to be the etiological agent. all the patients were non-smokers, and had symptoms of more than 6 months' duration. disease symptoms seemed to resolve following appropriate antibiotic treatment. | 1995 | 7660087 |
| chlamydia pneumoniae infection in italian patients. | of 91 adult patients with respiratory tract infections, 13 (14%) had serological evidence of recent infection with chlamydia pneumoniae. the clinical picture was consistent with asthmatic bronchitis in three patients, whilst exacerbations of chronic obstructive pulmonary disease were present in five subjects and, pneumonia was diagnosed in the remaining five. our findings provide evidence of an aetiological association between c. pneumoniae and respiratory infections in our region (bari, south i ... | 1995 | 7663485 |
| characterization of a neutralizing monoclonal antibody directed at variable domain i of the major outer membrane protein of chlamydia trachomatis c-complex serovars. | a monoclonal antibody (mab), c10, that neutralized in vitro the infectivity of serovars c, i, j, and l3 (members of the c and c-related complexes) of chlamydia trachomatis was identified. of the 15 major serovars and the mouse pneumonitis strain of c. trachomatis, chlamydia psittaci, and chlamydia pneumoniae, which were used as nontreated and heat-treated (56 degrees c, 30 min) antigens in a dot blot assay, only serovars c, i, j, and l3 were recognized with both the native and treated antigens. ... | 1993 | 7681045 |
| atypical pneumonias in children. | the major agents responsible for atypical pneumonia in children include a wide variety of organisms, one mycoplasma species, two chlamydia species, a rickettsia, and one fastidious bacterium. mycoplasma pneumoniae and c. pneumoniae together may be responsible for over 40% of these infections. recognition of the role that these agents play in pneumonia is important since many of the diagnostic methods used to detect these organisms are not available in most hospital microbiology laboratories. if ... | 1995 | 7718203 |
| more on chlamydia pneumonia and meningoencephalitis. | | 1995 | 7990880 |
| serologic evidence of respiratory and rickettsial infections among somali refugees. | somali refugees living in a camp located in djibouti were studied in october 1991 and may 1992. the refugees had been living at the camp for about two years. the median age of volunteers was 25 years, of whom 69% were female. paired sera obtained seven months apart were evaluated by complement fixation, microimmunofluorescence, indirect fluorescent antibody, streptococcal antibody, and enzyme-linked immunosorbent assay techniques for evidence of pathogen infection. fifty-two percent, 31.3%, 8.0% ... | 1995 | 7741176 |
| [a case of pediatric chlamydia pneumoniae infection and properties of the isolate]. | chlamydia pneumoniae was isolated from the throat of a 2-year-old girl with upper respiratory illness. the isolate, shizuoka-37, was stained with c. pneumoniae specific monoclonal antibody (rr402), as well as the genus specific antibody (cultureset), but not with c. trachomatis specific monoclonal antibody (micro-trak). c. pneumoniae genome was amplified by polymerase chain reaction in the isolate. elementary bodies (eb) of the isolate was round shaped by electron micrograph. | 1994 | 7996018 |
| effects of two antibiotic regimens on course and persistence of experimental chlamydia pneumoniae twar pneumonitis. | we studied the effects of two antibiotic regimens on the course of chlamydia pneumoniae infection in the lungs of swiss webster mice. after intranasal challenge with isolates ar-388 (1.3 x 10(7) inclusion-forming units per mouse) and ar-39 (1.5 x 10(6) inclusion-forming units per mouse), groups of animals were treated with either doxycycline (10 mg/kg of body weight once a day for 3 days), azithromycin (10 mg/kg [single dose]), or saline. responses were assessed by the isolation of organisms in ... | 1995 | 7695327 |
| interpretation of chlamydia trachomatis antibody response in chlamydial oculogenital infection. | to study: (a) the chlamydial antibody response (to the d-k serovars) using the micro-immunofluorescence (micro-if) test in the following groups: (i) chlamydial genital infection only, (ii) chlamydial ocular infection only, (iii) combined chlamydial ocular and genital infection (oculo-genital infection), (iv) chlamydial ocular infection with chlamydia-negative non-gonococcal urethritis, (v) adenovirus conjunctivitis (control group 1), (vi) male partners of group i-iv with no chlamydial oculogenit ... | 1995 | 7744422 |
| infection with chlamydia pneumoniae in infants and children with acute lower respiratory tract disease. | the role of chlamydia pneumoniae in the etiology of acute lower respiratory tract infections in infants and children is little understood. we studied the prevalence of c. pneumoniae infection in hospitalized infants and children with acute lower respiratory tract disease by cell culture, polymerase chain reaction (pcr), enzyme immunoassay and serology. of 290 patients with a mean age of 3.7 years, only 3 (1%) were identified to be infected with c. pneumoniae. one child was positive in the cell c ... | 1995 | 7746693 |
| chlamydia pneumonia and meningoencephalitis. | | 1994 | 8028636 |
| chlamydia pneumoniae-induced ciliostasis in ciliated bronchial epithelial cells. | the ciliary activity of ciliated bronchial epithelial cells was studied after infection with chlamydia pneumoniae (strain tw-183) and chlamydia trachomatis (biovar l2 [434/bu]). c. pneumoniae, known to cause respiratory infections, had a marked ciliastatic effect, completely aborting ciliary motion within 48 h. this effect was not inhibited by inactivation of c. pneumoniae elementary bodies (ebs) by uv irradiation. in contrast, inactivation of ebs by heat (56 degrees c, 30 min) or by rabbit-spec ... | 1995 | 7751703 |
| high prevalence of antibodies to chlamydia pneumoniae; determinants of igg and iga seropositivity among jerusalem residents. | the prevalence of antibodies to chlamydia pneumoniae was examined in a stratified random sample of 581 jerusalem adult residents between august 1987 and march 1989. igg and iga titres were measured by microimmunofluorescence, and associations with smoking and socio-demographic variables were assessed. igg antibodies were found in 84.5% (95% confidence interval (ci): 80.4-87.9) of men and 68.7% (95% ci: 61.6-75.0) of women (p < 0.0001 for sex difference), indicating a very high rate of exposure i ... | 1995 | 7781734 |
| efficacy of a three day course of azithromycin in moderately severe community-acquired pneumonia. | this study was designed to evaluate the efficacy of a 3 day course of azithromycin in low to moderately severe community-acquired pneumonia. forty patients with low to moderately severe community-acquired pneumonia (29 males, 11 females, mean age 46 +/- 17 yrs; 20 pretreated with betalactams for 2-10 days with no results before admission to hospital; 18 with evidence of co-morbidity) were enrolled in an open, randomized study with azithromycin, 500 mg q.d. oral therapy for 3 days, versus clarith ... | 1995 | 7789484 |
| evaluation of the sensitivity and specificity of polymerase chain reaction test kit, amplicor chlamydia trachomatis. | the sensitivity and specificity of the polymerase chain reaction (pcr) test kit, amplicor chlamydia trachomatis, were examined by the use of purified elementary bodies (ebs), cells having inclusions containing reticulate bodies alone and 20 clinical isolates. the numbers of eb and inclusion of c. trachomatis at the detection limit were determined to be approximately 2 to 4 ebs and one inclusion per assay, respectively. no reaction occurred for c. psittaci and c. pneumoniae. all clinical isolates ... | 1994 | 8052164 |
| radiographic appearance of chlamydia pneumoniae (twar strain) respiratory infections. cbpis study group. community-based pneumonia incidence study. | to report the spectrum of radiographic findings associated with a new respiratory pathogen: chlamydia pneumoniae (twar strain). | 1994 | 8058954 |
| lp(a) lipoprotein, igg, iga and igm antibodies to chlamydia pneumoniae and hla class ii genotype in early coronary artery disease. | the associations previously found between lipoprotein(a) (lp(a)) levels and atherosclerotic disorders, diabetes, rheumatoid arthritis and renal diseases suggest that lp(a) may be involved in autoimmune reactions. the relation found between lp(a) levels and the hla class ii genotype in males with early coronary artery disease (cad) further support that assumption. it was suggested that an autoimmune process, perhaps triggered by a concomitant intracellular infection may occur especially in patien ... | 1995 | 7605385 |
| sample preparation for chlamydia pneumoniae pcr. | fifty-three clinical specimens taken from the retropharyngeal mucosa of patients with longstanding respiratory tract infections were analyzed by polymerase chain reaction using two different methods for sample preparation. all specimens were divided into two aliquots, one treated with proteinase k, and the other with the amplicor sputum sample preparation kit. all tests were run in parallel, employing a primer pair specific for chlamydia pneumoniae. of the samples prepared with the amplicor kit ... | 1995 | 7612262 |
| [lung infections in children. iv. pneumonia due to chlamydia pneumoniae]. | chlamydia pneumoniae is the third strain of chlamydia and transmission is presumed to be by droplet spread from symptomatic patients. the authors show a literature scientific review on subject-matter emphasizing several sporadic and epidemic case of illness in every age, first months excepted. the described cases are few and therefore clinical characteristics are shadowy. certain clinical features are suggesting of severe pneumonia with fever and pharyngitis without exudate. in the childhood and ... | 1994 | 8090147 |
| prevalence of chlamydia pneumoniae in acute lower respiratory infection in the pediatric population in japan. | chlamydia pneumoniae has been established as an important etiologic agent of acute respiratory tract infection in humans, especially in adults. however, there is little information available on c. pneumoniae infection in the pediatric age group. the microimmunofluorescence test and chlamydia pneumoniae-specific polymerase chain reaction (pcr) method were applied to reveal the role of c. pneumoniae as an etiologic agent of acute lower respiratory tract infection in children in japan. among 136 pa ... | 1994 | 8091972 |
| prevalence of asymptomatic nasopharyngeal carriage of chlamydia pneumoniae in subjectively healthy adults: assessment by polymerase chain reaction-enzyme immunoassay and culture. | although chlamydia pneumoniae is a well-described and common respiratory tract pathogen, up to 90% of infections with this organism are thought to be asymptomatic. because asymptomatic infection with c. pneumoniae has not been studied in a systematic manner, we conducted a prospective study of healthy adults to establish the prevalence of asymptomatic infection. nasopharyngeal swab specimens were obtained from 104 subjectively healthy people and evaluated by culture and polymerase chain reaction ... | 1995 | 7619996 |
| in vitro activities of opc-17116, a new quinolone; ofloxacin; and sparfloxacin against chlamydia pneumoniae. | the in vitro susceptibilities of 12 strains of chlamydia pneumonia to a new quinolone, opc-17116; ofloxacin; and sparfloxacin were determined. opc-17116 was slightly less active than sparfloxacin but more active than ofloxacin, with a mic for 90% of strains tested and a minimal chlamydiacidal concentration for 90% of strains tested of 0.5 micrograms/ml. | 1994 | 8092845 |
| increasing prevalence of specific antibodies to chlamydia pneumoniae in sweden. | | 1993 | 8094155 |
| chlamydia pneumoniae and atherosclerosis. | | 1993 | 8096020 |
| replication of chlamydia trachomatis and c. pneumoniae in the human monocytic cell line u-937. | to elucidate whether chlamydia trachomatis and c. pneumoniae infections occur to a significant extent in monocytes-macrophages, the human monocytic cell line, u-937, was infected with c. trachomatis l2 or c. pneumoniae tw-183. chlamydial dna and genus-specific antigens of the lipopolysaccharides (lps) in epitopes of the chlamydial cell wall were detected from c. trachomatis l2-inoculated monocytes over a period of 150 days after inoculation and from the c. pneumoniae tw-183-inoculated cells duri ... | 1995 | 7884800 |
| clinical aspects of chlamydia pneumoniae infection. | this recently recognised member of the genus chlamydia is one of the most widespread pathogens of man, though up to 90% of infected people have few or no symptoms. several studies have estimated the population prevalence of antibodies to c. pneumoniae at 40-55% in the northern hemisphere, and over 60% in under-developed countries. the incidence of infections follows a cyclical pattern, with peaks at regular intervals of 2-10 years, but no apparent seasonal periodicity. nosocomial transmission ma ... | 1995 | 7899384 |
| lack of evidence of chlamydia pneumoniae infection in infants with acute lower respiratory tract disease. | in order to determine whether there is serologic evidence of chlamydia pneumoniae infection in young infants with acute lower respiratory tract infection, serum samples from 86 subjects aged less than 6 months were assayed for igg and igm antibodies to chlamydia pneumoniae using a microimmunofluorescence method. infants hospitalized in toronto, canada, were enrolled between 15 march 1991 and 15 march 1992. no patient had infection determined by the serologic results. igg antibody was detected at ... | 1993 | 8112356 |
| remarkable sequence relatedness in the dna encoding the major outer membrane protein of chlamydia psittaci (koala type i) and chlamydia pneumoniae. | dna encoding the major outer membrane protein (momp) of the koala type-i strain of chlamydia psittaci (pathogen responsible for blindness and infertility in koalas) was cloned and sequenced. comparison with momp gene sequences from other chlamydial species revealed a remarkable degree of homology (> 97%) with that of the human pathogen, chlamydia pneumoniae. in comparison, the sequence only shared 75% dna sequence homology with other c. psittaci members and 69% homology with c. trachomatis. the ... | 1994 | 8125292 |
| screening for antibody to chlamydia pneumoniae by the complement fixation test. | we performed a retrospective survey for antibody to chlamydia pneumoniae, by the microimmunofluorescence (mif) test, on 120 sera that were previously determined to be positive for antibody to ornithosis antigen by the complement fixation (cf) test. the panel of sera comprised 40 paired acute and convalescent sera, and 40 single samples, from 80 patients. of these patients, 60% were considered to be serologically positive for c. pneumoniae, based on the antibody titers of igg, igm, or both. there ... | 1994 | 7924219 |
| chlamydia trachomatis species specific serology: immunocomb chlamydia bivalent versus microimmunofluorescence (mif). | the immunocomb chlamydia bivalent igg/iga (orgenics, israel) is a new quantitative serologic test that employs lps extracted chlamydia trachomatis l2 and lps extracted chlamydia pneumoniae elementary bodies on two separate antigenic spots. the bivalent c. trachomatis specific test results were compared with microimmunofluorescence (mif), the gold standard of chlamydial species specific serology. for c. trachomatis igg the bivalent was highly concordant with the mif: the rate of positive titres ( ... | 1994 | 7927811 |
| chlamydia pneumoniae--a new causative agent of reactive arthritis and undifferentiated oligoarthritis. | to examine whether reactive arthritis (rea) known to occur after a urogenital infection with chlamydia trachomatis can also follow an infection with chlamydia pneumoniae, a recently described species of chlamydiae that is a common cause of respiratory tract infections. | 1994 | 8129453 |
| pro: antibiotics for chronic bronchitis with exacerbations. | over the years, there has emerged a considerable body of evidence supporting the importance of antimicrobial therapy in exacerbations of chronic bronchitis. the following lines of evidence suggest that most acute exacerbations are caused by bacterial infection: (1) the individual with chronic bronchitis is susceptible to bacterial infection as a consequence of local damage from prolonged cigarette smoking; (2) subtle defects in the local immune system can be shown, including impaired particle tr ... | 1993 | 7938921 |
| humoral immune response to plasmid protein pgp3 in patients with chlamydia trachomatis infection. | we identified, by two-dimensional electrophoretic analysis and microsequencing, a protein of chlamydia trachomatis elementary bodies which corresponds to the polypeptide (pgp3) encoded by open reading frame 3 (orf3). amino acid analysis showed that the first residue (gly) found in the native protein is the one encoded by the second orf3 codon, implying a typical bacterial removal of the first met residue. relatively large amounts of recombinant pgp3 (r-pgp3) in a stable, water-soluble form were ... | 1994 | 7960130 |
| chlamydia pneumoniae multiplies in human endothelial cells in vitro. | the ability of three c. pneumoniae isolates, kajaani 6, helsinki 12 and tw-183, to grow in human umbilical vein endothelial cells (huvec) and in an immortalized endothelial cell line ea.hy 926 was studied. all c. pneumoniae isolates were capable of multiplying in endothelial cells. ea.hy926 cells could support the growth of c. pneumoniae better than huvec, yet less efficiently than hl and hep-2 cells that are conventionally used in c. pneumoniae culturing. although centrifugation of the inoculum ... | 1994 | 7968460 |
| [occurrence of group (genus) specific chlamydia antibodies in the blood of patients with tonsillo-pharyngitis]. | a prospective study of 108 persons form novi sad population aged from 1 to over 40 years with tonsylopharingitis, showed that in 21.3% of the throat smears pyogenic streptococcus was present. in the blood serum, both in streptococcus positive and streptococcus negative subjects we confirmed the presence of antistreptosolin-0-antibodies. the occurrence of these antibodies was higher (p < 0.05) in streptococcus positive patients, especially in those aged from 1 to 14 years. on the basis of simulta ... | 1993 | 7968817 |
| chlamydial serology in genital infections: immunocomb versus ipazyme. | the immunocomb chlamydia trachomatis igg/iga (orgenics, israel) is a new serologic test using c. trachomatis l2 elementary bodies (washington research foundation, seattle) as antigen. the ipazyme igg/iga test (savyon, israel) employs whole cells with c. trachomatis l2 inclusions, i.e. elementary and reticulate bodies. theoretically, the immunocomb is expected to be less cross-reactive (lps) with chlamydia pneumoniae than the ipazyme (lps and reticulate body group specific antigens). compared wit ... | 1993 | 8132368 |
| [experimental study on the mechanisms of chlamydia pneumoniae respiratory infection in mice with former chlamydial exposure]. | to compare the differences in the severities, host defense responses and clinical courses c. pneumoniae respiratory tract infections between the initial and second challenge of chlamydia, an experimental c. pneumoniae respiratory infection model using mice was established and the following studies were carried out. for the initial infection mice were challenged with c. pneumoniae, strain tw-183, by nasal instillation. no animals died from this initial infection. the second exposure to c. pneumon ... | 1994 | 8138679 |
| age specific prevalence of antibodies against chlamydia pneumoniae in iceland. | chlamydia pneumoniae is a newly recognized common cause of respiratory tract infections. the aim of this study was to examine its prevalence in iceland. the study was based on 1020 serum samples from individuals 0-99 years old. the samples were divided into 10-year age groups. igg and igm antibodies were determined with microimmunofluorescence assay. an igg titer > or = 32 and igm titer > or = 16 were considered positive. the prevalence of positive igg titer in the study population was 53 +/- 16 ... | 1994 | 7984969 |
| protective effects of sparfloxacin in experimental pneumonia caused by chlamydia pneumoniae in leukopenic mice. | the in vivo antichlamydial activities of sparfloxacin and reference drugs were examined in a experimental model of pneumonia caused by chlamydia pneumoniae in leukopenic mice; their in vitro activities were also examined. the most potent agents in vitro were sparfloxacin (mics for c. pneumoniae kajaani and iol 207, (0.031 and 0.031 micrograms/ml, respectively), clarithromycin (0.031 and 0.031 micrograms/ml, respectively), and minocycline (0.031 and 0.031 micrograms/ml, respectively); these were ... | 1994 | 7986006 |